Uncovering elevated tau TPP motif phosphorylation in the brain of Alzheimer's disease patients
DISCUSSION: We conclude that there is an elevation of TPP tau phosphorylation in AD brains as disease advances. The regional variability of pTPP tau suggests that examining different phosphorylation sites is essential for a comprehensive assessment of tau pathology.PMID:38041855 | DOI:10.1002/alz.13557 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - December 2, 2023 Category: Psychiatry Authors: Jean-Pierre Bellier Yuqi Cai Sarah M Alam Thorsten Wiederhold Arica Aiello Jonathan S Vogelgsang Sabina Berretta Jasmeer P Chhatwal Dennis J Selkoe Lei Liu Source Type: research

When the central integrator disintegrates: A review of the role of the thalamus in cognition and dementia
Alzheimers Dement. 2023 Dec 2. doi: 10.1002/alz.13563. Online ahead of print.ABSTRACTThe thalamus is a complex neural structure with numerous anatomical subdivisions and intricate connectivity patterns. In recent decades, the traditional view of the thalamus as a relay station and "gateway to the cortex" has expanded in recognition of its role as a central integrator of inputs from sensory systems, cortex, basal ganglia, limbic systems, brain stem nuclei, and cerebellum. As such, the thalamus is critical for numerous aspects of human cognition, mood, and behavior, as well as serving sensory processing and motor functions. ...
Source: The Journal of Alzheimers Association - December 2, 2023 Category: Psychiatry Authors: J Matthijs Biesbroek Marieke G Verhagen Stefan van der Stigchel Geert Jan Biessels Source Type: research

Multimorbidity, cognitive phenotypes, and Alzheimer's disease plasma biomarkers in older adults: A population-based study
DISCUSSION: Multimorbidity burden and clusters are differentially associated with subtypes of dementia and MCI and AD-related plasma biomarkers in older adults.HIGHLIGHTS: We used hierarchical clustering to generate five clusters of multimorbidity. The presence and load of multimorbidity were associated with dementia and mild cognitive impairment. Multimorbidity clusters were differentially associated with subtypes of dementia and Alzheimer's disease plasma biomarkers.PMID:38041805 | DOI:10.1002/alz.13519 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - December 2, 2023 Category: Psychiatry Authors: Yifei Ren Yuanjing Li Na Tian Rui Liu Yi Dong Tingting Hou Cuicui Liu Xiaolei Han Xiaodong Han Lidan Wang Davide Liborio Vetrano Tiia Ngandu Alessandra Marengoni Miia Kivipelto Yongxiang Wang Lin Cong Yifeng Du Chengxuan Qiu Source Type: research

Spouses of individuals living with mild cognitive impairment or dementia in the United States: A descriptive, population-based study
We described their socio-demographic and health characteristics and quantified socio-demographic inequities.RESULTS: Among community-dwelling adults ≥ 50 years old, 6% of women and 4% of men co-resided with a spouse with probable CI/dementia. Among those who were married/partnered, the prevalence of spousal dementia was greater for Black and Hispanic adults compared to their White counterparts, and for those with lower versus higher educational attainment. Among spouses, activities of daily living disability, depression, and past 2-year hospitalization was common.DISCUSSION: Millions of older adults, disproportionately B...
Source: The Journal of Alzheimers Association - December 2, 2023 Category: Psychiatry Authors: Jacqueline M Torres Karla Renata Flores Romero Ashwin A Kotwal Ruijia Chen Tanisha Hill-Jarrett Uchechi A Mitchell Medellena Maria Glymour Source Type: research

Association of MGMT and BIN1 genes with Alzheimer's disease risk across sex and APOE ε4 status
Alzheimers Dement. 2023 Dec 2. doi: 10.1002/alz.13550. Online ahead of print.NO ABSTRACTPMID:38041824 | DOI:10.1002/alz.13550 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - December 2, 2023 Category: Psychiatry Authors: Julie Le Borgne EADB, GR at ACE, Degesco, EADI, GERAD, DemGene Philippe Amouyel Ole Andreassen Ruth Frikke-Schmidt Mikko Hiltunen Martin Ingelsson Alfredo Ramirez Giacomina Rossi Agustin Ruiz Pascual Sanchez-Juan Rebecca Sims Kristel Sleegers Magda Tsolak Source Type: research

Uncovering elevated tau TPP motif phosphorylation in the brain of Alzheimer's disease patients
DISCUSSION: We conclude that there is an elevation of TPP tau phosphorylation in AD brains as disease advances. The regional variability of pTPP tau suggests that examining different phosphorylation sites is essential for a comprehensive assessment of tau pathology.PMID:38041855 | DOI:10.1002/alz.13557 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - December 2, 2023 Category: Psychiatry Authors: Jean-Pierre Bellier Yuqi Cai Sarah M Alam Thorsten Wiederhold Arica Aiello Jonathan S Vogelgsang Sabina Berretta Jasmeer P Chhatwal Dennis J Selkoe Lei Liu Source Type: research

When the central integrator disintegrates: A review of the role of the thalamus in cognition and dementia
Alzheimers Dement. 2023 Dec 2. doi: 10.1002/alz.13563. Online ahead of print.ABSTRACTThe thalamus is a complex neural structure with numerous anatomical subdivisions and intricate connectivity patterns. In recent decades, the traditional view of the thalamus as a relay station and "gateway to the cortex" has expanded in recognition of its role as a central integrator of inputs from sensory systems, cortex, basal ganglia, limbic systems, brain stem nuclei, and cerebellum. As such, the thalamus is critical for numerous aspects of human cognition, mood, and behavior, as well as serving sensory processing and motor functions. ...
Source: The Journal of Alzheimers Association - December 2, 2023 Category: Psychiatry Authors: J Matthijs Biesbroek Marieke G Verhagen Stefan van der Stigchel Geert Jan Biessels Source Type: research

Multimorbidity, cognitive phenotypes, and Alzheimer's disease plasma biomarkers in older adults: A population-based study
DISCUSSION: Multimorbidity burden and clusters are differentially associated with subtypes of dementia and MCI and AD-related plasma biomarkers in older adults.HIGHLIGHTS: We used hierarchical clustering to generate five clusters of multimorbidity. The presence and load of multimorbidity were associated with dementia and mild cognitive impairment. Multimorbidity clusters were differentially associated with subtypes of dementia and Alzheimer's disease plasma biomarkers.PMID:38041805 | DOI:10.1002/alz.13519 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - December 2, 2023 Category: Psychiatry Authors: Yifei Ren Yuanjing Li Na Tian Rui Liu Yi Dong Tingting Hou Cuicui Liu Xiaolei Han Xiaodong Han Lidan Wang Davide Liborio Vetrano Tiia Ngandu Alessandra Marengoni Miia Kivipelto Yongxiang Wang Lin Cong Yifeng Du Chengxuan Qiu Source Type: research

Spouses of individuals living with mild cognitive impairment or dementia in the United States: A descriptive, population-based study
We described their socio-demographic and health characteristics and quantified socio-demographic inequities.RESULTS: Among community-dwelling adults ≥ 50 years old, 6% of women and 4% of men co-resided with a spouse with probable CI/dementia. Among those who were married/partnered, the prevalence of spousal dementia was greater for Black and Hispanic adults compared to their White counterparts, and for those with lower versus higher educational attainment. Among spouses, activities of daily living disability, depression, and past 2-year hospitalization was common.DISCUSSION: Millions of older adults, disproportionately B...
Source: The Journal of Alzheimers Association - December 2, 2023 Category: Psychiatry Authors: Jacqueline M Torres Karla Renata Flores Romero Ashwin A Kotwal Ruijia Chen Tanisha Hill-Jarrett Uchechi A Mitchell Medellena Maria Glymour Source Type: research

Association of MGMT and BIN1 genes with Alzheimer's disease risk across sex and APOE ε4 status
Alzheimers Dement. 2023 Dec 2. doi: 10.1002/alz.13550. Online ahead of print.NO ABSTRACTPMID:38041824 | DOI:10.1002/alz.13550 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - December 2, 2023 Category: Psychiatry Authors: Julie Le Borgne EADB, GR at ACE, Degesco, EADI, GERAD, DemGene Philippe Amouyel Ole Andreassen Ruth Frikke-Schmidt Mikko Hiltunen Martin Ingelsson Alfredo Ramirez Giacomina Rossi Agustin Ruiz Pascual Sanchez-Juan Rebecca Sims Kristel Sleegers Magda Tsolak Source Type: research

Uncovering elevated tau TPP motif phosphorylation in the brain of Alzheimer's disease patients
DISCUSSION: We conclude that there is an elevation of TPP tau phosphorylation in AD brains as disease advances. The regional variability of pTPP tau suggests that examining different phosphorylation sites is essential for a comprehensive assessment of tau pathology.PMID:38041855 | DOI:10.1002/alz.13557 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - December 2, 2023 Category: Psychiatry Authors: Jean-Pierre Bellier Yuqi Cai Sarah M Alam Thorsten Wiederhold Arica Aiello Jonathan S Vogelgsang Sabina Berretta Jasmeer P Chhatwal Dennis J Selkoe Lei Liu Source Type: research

When the central integrator disintegrates: A review of the role of the thalamus in cognition and dementia
Alzheimers Dement. 2023 Dec 2. doi: 10.1002/alz.13563. Online ahead of print.ABSTRACTThe thalamus is a complex neural structure with numerous anatomical subdivisions and intricate connectivity patterns. In recent decades, the traditional view of the thalamus as a relay station and "gateway to the cortex" has expanded in recognition of its role as a central integrator of inputs from sensory systems, cortex, basal ganglia, limbic systems, brain stem nuclei, and cerebellum. As such, the thalamus is critical for numerous aspects of human cognition, mood, and behavior, as well as serving sensory processing and motor functions. ...
Source: The Journal of Alzheimers Association - December 2, 2023 Category: Psychiatry Authors: J Matthijs Biesbroek Marieke G Verhagen Stefan van der Stigchel Geert Jan Biessels Source Type: research

Brain metabolic network covariance and aging in a mouse model of Alzheimer's disease
DISCUSSION: The current study replicates clinical AD findings and indicates that metabolic network covariance modeling provides a translational tool to assess disease progression in AD models.PMID:38032015 | DOI:10.1002/alz.13538 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - November 30, 2023 Category: Psychiatry Authors: Evgeny J Chumin Charles P Burton Rebecca Silvola Ethan W Miner Scott C Persohn Mattia Veronese Paul R Territo Source Type: research

Galectin-3 is upregulated in frontotemporal dementia patients with subtype specificity
We examined Gal-3 levels in brain, serum, and cerebrospinal fluid (CSF) samples of patients with FTD and controls. Multiple linear regressions between Gal-3 levels and other FTD markers were explored.RESULTS: Gal-3 levels were increased significantly in patients with FTD, mainly across brain tissue and CSF, compared to controls. Remarkably, Gal-3 levels were higher in cases with tau pathology than TAR-DNA Binding Protein 43 (TDP-43) pathology. Only MAPT mutation carriers displayed increased Gal-3 levels in CSF samples, which correlated with total tau and 14-3-3.DISCUSSION: Our findings underscore the potential of Gal-3 as ...
Source: The Journal of Alzheimers Association - November 29, 2023 Category: Psychiatry Authors: Sergi Borrego- Écija Agn ès Pérez-Millan Anna Antonell Laura Fort-Aznar Elif Kaya-Tilki Alberto Le ón-Halcón Albert Llad ó Laura Molina-Porcel Mircea Balasa Jordi Junc à-Parella Javier Vitorica Jose Luis Venero Tomas Deierborg Antonio Boza-Serrano Source Type: research