The Journal of Alzheimers Association This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Deriving life-course residential histories in brain bank cohorts: A feasibility study
DISCUSSION: This novel method demonstrates feasibility, reproducibility, and rigor for historic data collection. To our knowledge, this is the first study to show that public data tracing methods for brain bank decedent residential history development can be used to better integrate the social exposome with biobank specimens.HIGHLIGHTS: Public data tracing compares favorably to survey-based residential history. Public data tracing is feasible and reproducible between archivists. Archivists achieved 89.7% agreement at the address level. This method identifies residences for nearly 80% of life-years, on average. This novel m...
Source: The Journal of Alzheimers Association - March 18, 2024 Category: Psychiatry Authors: Eleanna M Melcher Leigha Vilen Aly Pfaff Sarah Lim Amanda DeWitt W Ryan Powell Barbara B Bendlin Amy J H Kind Source Type: research

Delineating cognitive resilience using fractal regulation: Cross-sectional and longitudinal evidence from the Rush Memory and Aging Project
We examined associations of fractal regulation with neuropathologies and longitudinal cognitive changes in 533 older participants who were followed annually with actigraphy and cognitive assessments until death with brain autopsy performed. Two measures for fractal patterns were extracted from actigraphy, namely, α1 (representing the fractal regulation at time scales of <90 min) and α2 (for time scales 2 to 10 h).RESULTS: We found that larger α1 was associated with lower burdens of Lewy body disease or cerebrovascular disease pathologies; both α1 and α2 were associated with cognitive decline. They explained an addi...
Source: The Journal of Alzheimers Association - March 18, 2024 Category: Psychiatry Authors: Peng Li Chenlu Gao Lei Yu Lei Gao Ruixue Cai David A Bennett Julie A Schneider Aron S Buchman Kun Hu Source Type: research

Association between hippocampal microglia, AD and LATE-NC, and cognitive decline in older adults
This study investigates the relationship between microglia inflammation in the hippocampus, brain pathologies, and cognitive decline.METHODS: Participants underwent annual clinical evaluations and agreed to brain donation. Neuropathologic evaluations quantified microglial burden in the hippocampus, amyloid beta (Aβ), tau tangles, and limbic age-related transactive response DNA-binding protein 43 (TDP-43) encephalopathy neuropathologic changes (LATE-NC), and other common brain pathologies. Mixed-effect and linear regression models examined the association of microglia with a decline in global and domain-specific cognitive ...
Source: The Journal of Alzheimers Association - March 18, 2024 Category: Psychiatry Authors: Alifiya Kapasi Lei Yu Sue E Leurgans Sonal Agrawal Patricia A Boyle David A Bennett Julie A Schneider Source Type: research

Dementia and mild cognitive impairment screening in an emergency homeless shelter
DISCUSSION: Older adults experiencing homelessness may have a high likelihood of dementia or MCI. Routine MoCA screening in older adults experiencing homelessness is feasible and can help to identify services needed to successfully exit homelessness.PMID:38494925 | DOI:10.1002/alz.13763 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - March 18, 2024 Category: Psychiatry Authors: Heather M Ross Primrose Dzenga Martha Myers Alisa Squires Stephanie Duncan Jamilyn Caradine Phillip Scharf Diana M Bowman Source Type: research

Wrist-worn actigraphy in agitated late-stage dementia patients: A feasibility study on digital inclusion
DISCUSSIONS: Wrist-worn actigraphy appears acceptable and feasible in late-stage agitated dementia patients. Accommodating the needs of both the patients and their carers may further improve compliance.PMID:38497216 | DOI:10.1002/alz.13772 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - March 18, 2024 Category: Psychiatry Authors: Ta-Wei Guu Anna-Katharine Brem Christopher P Albertyn Pooja Kandangwa Dag Aarsland Dominic Ffytche Source Type: research

Clinical validation of the PrecivityAD2 blood test: A mass spectrometry-based test with algorithm combining %p-tau217 and A β42/40 ratio to identify presence of brain amyloid
DISCUSSION: The PrecivityAD2 blood test showed strong clinical validity, with excellent agreement with brain amyloidosis by PET.PMID:38491912 | DOI:10.1002/alz.13764 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - March 16, 2024 Category: Psychiatry Authors: Matthew R Meyer Kristopher M Kirmess Stephanie Eastwood Traci L Wente-Roth Faith Irvin Mary S Holubasch Venky Venkatesh Ilana Fogelman Mark Monane Lucy Hanna Gil D Rabinovici Barry A Siegel Rachel A Whitmer Charles Apgar Randall J Bateman David M Holtzman Source Type: research

Adapting prescribing criteria for amyloid-targeted antibodies for adults with Down syndrome
Alzheimers Dement. 2024 Mar 13. doi: 10.1002/alz.13778. Online ahead of print.ABSTRACTPrior authorization criteria for Federal Drug Administration (FDA) approved immunotherapeutics, among the class of anti-amyloid monoclonal antibodies (mAbs), established by state drug formulary committees, are tailored for adults with late-onset Alzheimer's disease. This overlooks adults with Down syndrome (DS), who often experience dementia at a younger age and with different diagnostic assessment outcomes. This exclusion may deny DS adults access to potential disease-modifying treatments. To address this issue, an international expert p...
Source: The Journal of Alzheimers Association - March 14, 2024 Category: Psychiatry Authors: Hampus Hillerstrom Richard Fisher Matthew P Janicki Brian Chicoine Bradley T Christian Anna Esbensen Lucille Esralew Juan Fortea Sigan Hartley Jason Hassenstab Seth M Keller Sharon Krinsky-McHale Florence Lai Johannes Levin Mary McCarron Eric McDade Anne Source Type: research

Dementia, dementia's risk factors and premorbid brain structure are concentrated in disadvantaged areas: National register and birth-cohort geographic analyses
DISCUSSION: Disadvantaged neighborhoods have more residents with dementia, and decades before dementia is diagnosed, residents have more dementia-risk factors and brain-structure antecedents. Whether or not neighborhoods causally influence risk, they may offer scalable opportunities for primary dementia prevention.PMID:38482967 | DOI:10.1002/alz.13727 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - March 14, 2024 Category: Psychiatry Authors: Aaron Reuben Leah S Richmond-Rakerd Barry Milne Devesh Shah Amber Pearson Sean Hogan David Ireland Ross Keenan Annchen R Knodt Tracy Melzer Richie Poulton Sandhya Ramrakha Ethan T Whitman Ahmad R Hariri Terrie E Moffitt Avshalom Caspi Source Type: research