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BIN1 < sup > K358R < /sup > suppresses glial response to plaques in mouse model of Alzheimer's disease
DISCUSSION: The BIN1 K358R variant modulates amyloid pathology in 5xFAD mice, attenuates the astrocytic and oligodendrocytic responses to amyloid plaques, decreases damage markers, and elevates synaptic densities.HIGHLIGHTS: BIN1 rs138047593 (K358R) coding variant is associated with increased risk of LOAD. BIN1 K358R variant increases amyloid plaque load in 12-month-old 5xFAD mice. BIN1 K358R variant dampens astrocytic and oligodendrocytic response to plaques. BIN1 K358R variant decreases neuronal damage in 5xFAD mice. BIN1 K358R upregulates synaptic densities and modulates synaptic transmission.PMID:38460121 | DOI:10.1002...
Source: The Journal of Alzheimers Association - March 9, 2024 Category: Psychiatry Authors: Laura Fernandez Garcia-Agudo Zechuan Shi Ian F Smith Enik ö A Kramár Katelynn Tran Shimako Kawauchi Shuling Wang Sherilyn Collins Amber Walker Kai-Xuan Shi Jonathan Neumann Heidi Yahan Liang Celia Da Cunha Giedre Milinkeviciute Samuel Morabito Emily Miy Source Type: research

Data stewardship in FTLD research: Investigator and research participant views
This study identified a set of preliminary gaps and needs regarding data stewardship within FTLD research. The results offer initial insights on ethical challenges to data stewardship aimed at informing future guidelines and policies.PMID:38456576 | DOI:10.1002/alz.13719 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - March 8, 2024 Category: Psychiatry Authors: Jalayne J Arias Ana M Tyler Laura M Beskow Maria C Carillo Susan Dickinson Jill Goldman Mary A Majumder Michelle M Mello Heather M Snyder Jennifer S Yokoyama Source Type: research

Genetic modifiers of cognitive decline in PSEN1 E280A Alzheimer's disease
DISCUSSION: Impaired olfactory function has been associated with cognitive impairment in AD. Genetic variants in these or other genes could help to identify risk of faster memory decline in FAD and SAD patients.PMID:38450831 | DOI:10.1002/alz.13754 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - March 7, 2024 Category: Psychiatry Authors: Diego Sepulveda-Falla Jorge I V élez Natalia Acosta-Baena Ana Baena Sonia Moreno Susanne Krasemann Francisco Lopera Claudio A Mastronardi Mauricio Arcos-Burgos Source Type: research

Structural disconnectivity in postoperative delirium: A perioperative two-center cohort study in older patients
DISCUSSION: Preoperative structural disconnectivity was associated with POD. POD might lead to white matter depletion 3 and 12 months after surgery.PMID:38451782 | DOI:10.1002/alz.13749 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - March 7, 2024 Category: Psychiatry Authors: Marinus Fislage Stefan Winzeck Rebecca Woodrow Florian Lammers-Lietz Emmanuel A Stamatakis Marta M Correia Jacobus Preller Insa Feinkohl Jeroen Hendrikse Tobias Pischon Claudia D Spies Arjen J C Slooter Georg Winterer David K Menon Norman Zacharias BioCog Source Type: research

Association receives $25 million grant to enhance respite care for dementia caregivers
Alzheimers Dement. 2024 Mar 7. doi: 10.1002/alz.13787. Online ahead of print.NO ABSTRACTPMID:38453680 | DOI:10.1002/alz.13787 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - March 7, 2024 Category: Psychiatry Source Type: research

Nanoscale imaging of pT217-tau in aged rhesus macaque entorhinal and dorsolateral prefrontal cortex: Evidence of interneuronal trafficking and early-stage neurodegeneration
DISCUSSION: These data help to explain why pT217-tau predicts degeneration in AD and how it gains access to CSF and plasma to serve as a fluid biomarker.PMID:38445818 | DOI:10.1002/alz.13737 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - March 6, 2024 Category: Psychiatry Authors: Dibyadeep Datta Isabella Perone Denethi Wijegunawardana Feng Liang Yury M Morozov Jon Arellano Alvaro Duque Zhongcong Xie Christopher H van Dyck Mary Kate P Joyce Amy F T Arnsten Source Type: research

Blood tests for Alzheimer's disease: The impact of disease prevalence on test performance
Alzheimers Dement. 2024 Mar 6. doi: 10.1002/alz.13762. Online ahead of print.NO ABSTRACTPMID:38447004 | DOI:10.1002/alz.13762 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - March 6, 2024 Category: Psychiatry Authors: Mari L DeMarco Alicia Algeciras-Schimnich Melissa M Budelier Source Type: research

Diffusion MRI relates to plasma A β42/40 in PET negative participants without dementia
DISCUSSION: FW imaging changes distinguish plasma Aβ42/40 positive and negative groups, independent of group differences in cognitive status, Aβ PET status, and other plasma biomarkers (i.e., t-tau, p-tau181, glial fibrillary acidic protein, neurofilament light).HIGHLIGHTS: Plasma Aβ42/40 positivity is associated with brain microstructure decline. Plasma+/PET- demonstrated increased FW in 24 total GM and WM regions. Plasma+/PET- demonstrated decreased FAt in 66 total GM and WM regions. Whole-brain FW correlated with plasma Aβ42/40 and p-tau181 measures. Plasma+/PET- demonstrated decreased cortical volume and thickness....
Source: The Journal of Alzheimers Association - March 5, 2024 Category: Psychiatry Authors: Jesse C DeSimone Wei-En Wang David A Loewenstein Ranjan Duara Glenn E Smith Karen N McFarland Melissa J Armstrong Darren M Weber Warren Barker Stephen A Coombes David E Vaillancourt Source Type: research

Investigating the impact of hypertension with and without diabetes on Alzheimer's disease risk: A clinico-pathological study
DISCUSSION: HTN+/DM+ and HTN+/DM- increased AD risk compared to HTN-/DM-, but pathological differences between groups suggest targeted therapies may be warranted based on cardiovascular risk profiles.HIGHLIGHTS: AD risk was studied in hypertensive (HTN+) individuals with/without diabetes (DM+/-). HTN+/DM+ and HTN+/DM- both had an increased risk of AD compared to HTN-/DM-. Post mortem analysis identified neuropathological differences between HTN+/DM+ and HTN+/DM-. In HTN+/DM+, AD risk was greater in those with AD neuropathology and CAA. In HTN+/DM-, AD risk was greater in those with cerebrovascular neuropathology.PMID:38425...
Source: The Journal of Alzheimers Association - March 1, 2024 Category: Psychiatry Authors: Myuri Ruthirakuhan Walter Swardfager Lisa Xiong Bradley J MacIntosh Jennifer S Rabin Krista L Lanct ôt Julie Ottoy Joel Ramirez Julia Keith Sandra E Black Source Type: research

Early detection of diseases causing dementia using digital navigation and gait measures: A systematic review of evidence
Alzheimers Dement. 2024 Mar 1. doi: 10.1002/alz.13716. Online ahead of print.ABSTRACTWearable digital technologies capable of measuring everyday behaviors could improve the early detection of dementia-causing diseases. We conducted two systematic reviews following Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines to establish the evidence base for measuring navigation and gait, two everyday behaviors affected early in AD and non-AD disorders and not adequately measured in current practice. PubMed and Web of Science databases were searched for studies on asymptomatic and early-stage symp...
Source: The Journal of Alzheimers Association - March 1, 2024 Category: Psychiatry Authors: Giedr ė Čepukaitytė Coco Newton Dennis Chan Source Type: research

Genetic diversity promotes resilience in a mouse model of Alzheimer's disease
DISCUSSION: Increasing genetic diversity promotes resilience to AD-related pathogenesis, relative to an inbred C57BL/6J background, reinforcing the importance of genetic diversity in uncovering resilience in the development of AD.HIGHLIGHTS: Genetic diversity's impact on AD in mice was explored. Diverse F1 mouse strains were used for AD study, via the Collaborative Cross. Strain-specific variations in AD pathology, glia, and transcription were found. Strains resilient to plaque formation and plasma neurofilament light chain (NfL) increases were identified. Correlations with human AD transcriptomics were observed.PMID:38426...
Source: The Journal of Alzheimers Association - March 1, 2024 Category: Psychiatry Authors: Neelakshi Soni Lindsay A Hohsfield Kristine M Tran Shimako Kawauchi Amber Walker Dominic Javonillo Jimmy Phan Dina Matheos Celia Da Cunha Asli Uyar Giedre Milinkeviciute Angela Gomez-Arboledas Katelynn Tran Catherine C Kaczorowski Marcelo A Wood Andrea J Source Type: research

Analysis of agreement between measures of subjective cognitive impairment and probable dementia in the National Health and Aging Trends Study
DISCUSSION: SCI sensitivity (63.4%) and specificity (92.5%) against dementia were comparable with similar metrics for the NHATS probable dementia measure against the "gold-standard" Aging, Demographics, and Memory Study-based dementia criteria, implying that population-based surveys may afford cost-effective opportunities for dementia surveillance to assess risk and inform policy.HIGHLIGHTS: The prevalence of subjective cognitive impairment (SCI) is generally higher than that of a validated measure of probable dementia, particularly within the youngest age group, females, Whites, and persons with a college or higher degree...
Source: The Journal of Alzheimers Association - March 1, 2024 Category: Psychiatry Authors: Linda C Chyr Jennifer L Wolff Julie M Zissimopoulos Emmanuel F Drabo Source Type: research