BIN1 < sup > K358R < /sup > suppresses glial response to plaques in mouse model of Alzheimer's disease

DISCUSSION: The BIN1 K358R variant modulates amyloid pathology in 5xFAD mice, attenuates the astrocytic and oligodendrocytic responses to amyloid plaques, decreases damage markers, and elevates synaptic densities.HIGHLIGHTS: BIN1 rs138047593 (K358R) coding variant is associated with increased risk of LOAD. BIN1 K358R variant increases amyloid plaque load in 12-month-old 5xFAD mice. BIN1 K358R variant dampens astrocytic and oligodendrocytic response to plaques. BIN1 K358R variant decreases neuronal damage in 5xFAD mice. BIN1 K358R upregulates synaptic densities and modulates synaptic transmission.PMID:38460121 | DOI:10.1002/alz.13767

Source: The Journal of Alzheimers Association - March 9, 2024 Category: Psychiatry Authors: Laura Fernandez Garcia-Agudo Zechuan Shi Ian F Smith Enik ö A Kramár Katelynn Tran Shimako Kawauchi Shuling Wang Sherilyn Collins Amber Walker Kai-Xuan Shi Jonathan Neumann Heidi Yahan Liang Celia Da Cunha Giedre Milinkeviciute Samuel Morabito Emily Miy Source Type: research