The Journal of Alzheimers Association This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Adapting prescribing criteria for amyloid-targeted antibodies for adults with Down syndrome
Alzheimers Dement. 2024 Mar 13. doi: 10.1002/alz.13778. Online ahead of print.ABSTRACTPrior authorization criteria for Federal Drug Administration (FDA) approved immunotherapeutics, among the class of anti-amyloid monoclonal antibodies (mAbs), established by state drug formulary committees, are tailored for adults with late-onset Alzheimer's disease. This overlooks adults with Down syndrome (DS), who often experience dementia at a younger age and with different diagnostic assessment outcomes. This exclusion may deny DS adults access to potential disease-modifying treatments. To address this issue, an international expert p...
Source: The Journal of Alzheimers Association - March 14, 2024 Category: Psychiatry Authors: Hampus Hillerstrom Richard Fisher Matthew P Janicki Brian Chicoine Bradley T Christian Anna Esbensen Lucille Esralew Juan Fortea Sigan Hartley Jason Hassenstab Seth M Keller Sharon Krinsky-McHale Florence Lai Johannes Levin Mary McCarron Eric McDade Anne Source Type: research

Dementia, dementia's risk factors and premorbid brain structure are concentrated in disadvantaged areas: National register and birth-cohort geographic analyses
DISCUSSION: Disadvantaged neighborhoods have more residents with dementia, and decades before dementia is diagnosed, residents have more dementia-risk factors and brain-structure antecedents. Whether or not neighborhoods causally influence risk, they may offer scalable opportunities for primary dementia prevention.PMID:38482967 | DOI:10.1002/alz.13727 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - March 14, 2024 Category: Psychiatry Authors: Aaron Reuben Leah S Richmond-Rakerd Barry Milne Devesh Shah Amber Pearson Sean Hogan David Ireland Ross Keenan Annchen R Knodt Tracy Melzer Richie Poulton Sandhya Ramrakha Ethan T Whitman Ahmad R Hariri Terrie E Moffitt Avshalom Caspi Source Type: research

Cognitive resilience/reserve: Myth or reality? A review of definitions and measurement methods
CONCLUSIONS: The review underscores the significance of comprehending CR in the context of both normal and pathological brain aging and emphasizes the importance of further research to identify and enhance this protective factor for cognitive preservation in both healthy and neurologically impaired older individuals.HIGHLIGHTS: This review examines the concept of cognitive reserve in brain aging, in the context of dementia and its early stages. We have evaluated the methods commonly used to define and measure cognitive reserve. Sociobehavioral proxies, neuroimaging, and electrophysiological and genetic measures are discuss...
Source: The Journal of Alzheimers Association - March 13, 2024 Category: Psychiatry Authors: Chiara Pappalettera Claudia Carrarini Francesca Miraglia Fabrizio Vecchio Paolo M Rossini Source Type: research

Adapted problem adaptation therapy for depression in mild to moderate Alzheimer's disease dementia: A randomized controlled trial
DISCUSSION: An eight-session course of adapted PATH plus two booster sessions administered within NHS dementia services was not effective treatment for depression in people with mild and moderate dementia. Future studies should examine the effect of more intensive and longer-term therapy.PMID:38477423 | DOI:10.1002/alz.13766 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - March 13, 2024 Category: Psychiatry Authors: Robert Howard Elizabeth Cort Charlotte Rawlinson Martin Wiegand Anne Downey Vanessa Lawrence Sube Banerjee Peter Bentham Chris Fox Rowan Harwood Rachel Hunter Gill Livingston Esme Moniz-Cook Monica Panca Malgorzata Raczek Chineze Ivenso Gregor Russell Ala Source Type: research

Amyloid pathology and vascular risk are associated with distinct patterns of cerebral white matter hyperintensities: A multicenter study in 3132 memory clinic patients
DISCUSSION: Vascular risk factors and Aß42 pathology have distinct signature WMH patterns. This regional vulnerability may incite future studies into how arteriolosclerosis and Aß42 pathology affect the brain's white matter.HIGHLIGHTS: Key dementia etiologies may be associated with specific patterns of white matter hyperintensities (WMH). We related WMH locations to vascular risk and cerebral Aβ42 status in 11 memory clinic cohorts. Aβ42 positive status was associated with posterior WMH in splenium and posterior thalamic radiation. Vascular risk was associated with anterior and infratentorial WMH. Amyloid pathology and...
Source: The Journal of Alzheimers Association - March 13, 2024 Category: Psychiatry Authors: J Matthijs Biesbroek Mirthe Coenen Charles DeCarli Evan M Fletcher Pauline M Maillard Alzheimer's Disease Neuroimaging Initiative Frederik Barkhof Josephine Barnes Thomas Benke Christopher P L H Chen Peter Dal-Bianco Anna Dewenter Marco Duering Christian Source Type: research

Racial and ethnic differences in the association between depressive symptoms and cognitive outcomes in older adults: Findings from KHANDLE and STAR
We examined whether baseline depressive symptoms were differentially associated with domain-specific cognition or cognitive decline by race/ethnicity. Depressive symptoms were associated with worse cognitive scores for all racial/ethnic groups across different domains examined. Higher depressive symptoms were associated with faster cognitive decline for semantic memory for Black and Latino participants. The results suggest a particularly harmful association between depressive symptoms and cognition in certain racial/ethnic groups.PMID:38477489 | DOI:10.1002/alz.13768 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - March 13, 2024 Category: Psychiatry Authors: Marcia P Jimenez Emma L Gause Kendra D Sims Eleanor Hayes-Larson Emily P Morris Evan Fletcher Jennifer Manly Paola Gilsanz Yenee Soh Maria Corrada Rachel A Whitmer Medellena Maria Glymour Source Type: research

APOE ε4 is associated with decreased synaptic density in cognitively impaired participants
DISCUSSION: The APOE ε4 allele was associated with decreased synaptic density in CI individuals and may be driven by AD biomarkers.PMID:38477490 | DOI:10.1002/alz.13775 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - March 13, 2024 Category: Psychiatry Authors: Kun He Binyin Li Jie Wang Ying Wang Zhiwen You Xing Chen Haijuan Chen Junpeng Li Qi Huang Qihao Guo Yiyun Henry Huang Yihui Guan Kewei Chen Jun Zhao Yulei Deng Fang Xie Source Type: research

Person-specific differences in ubiquitin-proteasome mediated proteostasis in human neurons
DISCUSSION: These findings reveal that genetic variation influences basal UPS activity in human neurons and differentially sensitizes them to external factors perturbing the UPS, leading to the accumulation of aggregation-prone proteins such as tau.HIGHLIGHTS: Polygenic risk score for AD is associated with the ubiquitin-proteasome system (UPS) in neurons. Basal proteasome activity correlates with aggregation-prone protein levels in neurons. Genetic variation affects the response to proteasome inhibition in neurons. Neuronal proteasome perturbation induces an elevation in specific proteins involved in proteostasis. Low basa...
Source: The Journal of Alzheimers Association - March 12, 2024 Category: Psychiatry Authors: Yi-Chen Hsieh Zachary M Augur Mason Arbery Nancy Ashour Katharine Barrett Richard V Pearse Earvin S Tio Duc M Duong Daniel Felsky Philip L De Jager David A Bennett Nicholas T Seyfried Tracy L Young-Pearse Source Type: research

Link among apolipoprotein E E4, gait, and cognition in neurodegenerative diseases: ONDRI study
DISCUSSION: Gait slowness in APOE E4 carriers with neurodegenerative diseases may indicate extensive gray matter changes associated with poor cognition.HIGHLIGHTS: APOE E4 and slow gait are risk factors for cognitive decline in neurodegenerative diseases. Slow gait and smaller gray matter volumes are associated, independently of APOE E4. Worse cognition in APOE E4 carriers with slow gait is explained by smaller GM volume. Gait slowness in APOE E4 carriers indicates poorer cognition-related brain changes.PMID:38470007 | DOI:10.1002/alz.13740 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - March 12, 2024 Category: Psychiatry Authors: Ryota Sakurai Frederico Pieruccini-Faria Benjamin Cornish Julia Fraser Malcolm A Binns Derek Beaton Allison Ann Dilliott Donna Kwan Joel Ramirez Brian Tan Christopher J M Scott Kelly M Sunderland Carmela Tartaglia Elizabeth Finger Lorne Zinman Morris Free Source Type: research