Cortical microinfarcts in adults with Down syndrome assessed with 3T-MRI

DISCUSSION: In DS, CMI are posteriorly distributed and related to ischemic but not hemorrhagic findings suggesting they might be associated with a specific ischemic CAA phenotype.HIGHLIGHTS: This is the first study to assess cortical microinfarcts (assessed with 3T magnetic resonance imaging) in adults with Down syndrome (DS). We studied the prevalence of cortical microinfarcts in DS and its relationship with age, the Alzheimer's disease (AD) clinical continuum, vascular risk factors, vascular neuroimaging findings, amyloid/tau/neurodegeneration biomarkers, and cognition. The prevalence of cortical microinfarcts was 11.8% in DS and increased with age and along the AD clinical continuum. Cortical microinfarcts were clustered in the parietal lobes, and were associated with lacunes and cortico-subcortical infarcts, but not hemorrhagic lesions. In DS, cortical microinfarcts are posteriorly distributed and related to ischemic but not hemorrhagic findings suggesting they might be associated with a specific ischemic phenotype of cerebral amyloid angiopathy.PMID:38644660 | DOI:10.1002/alz.13797

Source: The Journal of Alzheimers Association - April 22, 2024 Category: Psychiatry Authors: Mateus Rozalem Aranha Victor Montal Hilde van den Brink Jordi Pegueroles Maria Carmona-Iragui Laura Videla Lucia Maure Blesa Bessy Benejam Javier Arranz S ílvia Valldeneu Isabel Barroeta Susana Fern ández Laia Ribas Daniel Alcolea Sof ía González-Orti Source Type: research