PET helps diagnose treatable form of dementia
PET imaging could be a useful tool for diagnosis and treatment of idiopathic...Read more on AuntMinnie.comRelated Reading: FDG levels show link between Alzheimer's, Down syndrome SNMMI 2020: Image of the Year scans reveal 'super-agers' New tau PET tracer better targets source of Alzheimer's New PET technique visualizes early Alzheimer's disease PET tracer could more precisely diagnose Alzheimer's (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - September 16, 2020 Category: Radiology Source Type: news

NIH to fund PET imaging for Latino Alzheimer's study
The U.S. National Institutes of Health (NIH) has provided additional funding...Read more on AuntMinnie.comRelated Reading: MRI-trained CAD identifies cognitive impairment FDG levels show link between Alzheimer's, Down syndrome New tau PET tracer better targets source of Alzheimer's New PET technique visualizes early Alzheimer's disease PET tracer could more precisely diagnose Alzheimer's (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - September 14, 2020 Category: Radiology Source Type: news

Study underscores value of down syndrome clinic to you program
(Massachusetts General Hospital) A new software program effectively brings the expertise of Massachusetts General Hospital specialists to many more patients with Down syndrome. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - September 8, 2020 Category: International Medicine & Public Health Source Type: news

New insights into why people with down syndrome are at higher risk for leukemia
(Ann& Robert H. Lurie Children's Hospital of Chicago) Scientists from Stanley Manne Children's Research Institute at Ann& Robert H. Lurie Children's Hospital of Chicago were the first to examine endothelial cells - one of the main sources of blood production - for clues as to why people with Down syndrome have higher prevalence of leukemia. They identified a new set of genes that are overexpressed in endothelial cells of patients with Down syndrome. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - September 8, 2020 Category: Cancer & Oncology Source Type: news

What Is Down Syndrome?
Title: What Is Down Syndrome?Category: Diseases and ConditionsCreated: 9/3/2020 12:00:00 AMLast Editorial Review: 9/3/2020 12:00:00 AM (Source: MedicineNet Kids Health General)
Source: MedicineNet Kids Health General - September 3, 2020 Category: Pediatrics Source Type: news

Research story tip: Down syndrome mice open door to better understanding of the disorder
(Johns Hopkins Medicine) Johns Hopkins Medicine researchers and their collaborators have created and characterized a new mouse replica of Down syndrome, long considered one of the most challenging disorders to simulate in laboratory animals. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - August 18, 2020 Category: International Medicine & Public Health Source Type: news

HIIT programs show benefits for those with Down syndrome
(University of Georgia) Incorporating high-intensity interval training, or HIIT, into exercise programs for individuals with Down syndrome may help achieve critical health outcomes in a more time-efficient manner, according to new researcher. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - August 4, 2020 Category: International Medicine & Public Health Source Type: news

FDG levels show link between Alzheimer's, Down syndrome
PET imaging has revealed reduced FDG uptake in key brain regions associated...Read more on AuntMinnie.comRelated Reading: PET, MRI uncover women's predisposition to Alzheimer's New tau PET tracer better targets source of Alzheimer's PET links lower sleep levels with Alzheimer's risk New PET technique visualizes early Alzheimer's disease PET tracer could more precisely diagnose Alzheimer's (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - July 29, 2020 Category: Radiology Source Type: news

Discovery of a novel drug candidate to develop effective treatments for brain disorders
(Istituto Italiano di Tecnologia - IIT) Researchers at IIT-Istituto Italiano di Tecnologia discovered a novel chemical compound, which has the potential to became a new drug for the treatment of core symptoms of brain disorders like Down syndrome and autism. Results are obtained in preclinical models where the new compound ameliorated difficulties in cognitive tasks, social interactions and repetitive behaviors. Researchers aim to create a start-up company in order to further develop this compound and make it a treatment for patients (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - July 10, 2020 Category: Biology Source Type: news

Down Syndrome Fast Facts
Read CNN's Fast Facts on Down syndrome. (Source: CNN.com - Health)
Source: CNN.com - Health - June 16, 2020 Category: Consumer Health News Source Type: news

656 Down's Syndrome Abortions in 2019
Department of Health and Social Care 2019 abortion statistics show 656 abortions where a baby had Down's syndrome. Under current law, abortion is allowed up to birth if a baby has a disability including Down's syndrome (Source: Disabled World)
Source: Disabled World - June 12, 2020 Category: Disability Tags: European Disability News Source Type: news

Janet Carr obituary
Psychologist whose 50-year study transformed attitudes to people with Down ’s syndromeIn 1964, Janet Carr, a clinical psychologist, was asked to work on a follow-up study of 54 six-week-old babies with Down ’s syndrome at the Maudsley hospital in London. Initially Carr, who has died aged 92, was going to track the children only until they were four, but it became one of the longest follow-up studies in the world.In 2014, a party was held at the House of Lords to celebrate the study running for 50 years. Chris Oliver, the director of the Cerebra centre for neurodevelopmental disorders at Birmingham University, c...
Source: Guardian Unlimited Science - May 8, 2020 Category: Science Authors: Penny Warren Tags: Down's syndrome Health Society Psychology Science Source Type: news

New therapeutic targets for treating memory impairment in Down syndrome
(IMIM (Hospital del Mar Medical Research Institute)) Researchers from Hospital del Mar Medical Research Institute studied the neural basis of intellectual disability in mice with Down syndrome and discovered that the neural networks of brain circuits relevant to memory and learning are over-activated and that the connectivity of these circuits is poor. They also identified biomarkers in brain rhythms that can predict memory deficits in the mice which are corrected by chronic treatment with a natural component of green tea, epigallocatechin gallate (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 5, 2020 Category: International Medicine & Public Health Source Type: news

Africa: Disabilities Should Not Exclude People from Receiving Dental Care
[allAfrica] In 2015, I had a client with Down Syndrome while working as a dentist in Ekiti State, southwest Nigeria. He came for a root canal treatment. As a competent dentist, I had a hard time treating the patient, because the dental facility did not have some of the equipment needed to treat People with Disabilities (PWDs).   Also, I did not know how go about communicating with PWDs about their dental care needs. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - March 31, 2020 Category: African Health Source Type: news

What Types of Memory Impairments are There in Children?
Discussion Memory is an important part of what distinguishes higher order species from others. Memory also is part of one’s self-identity. Difficulties in short-term memory can make common, everyday tasks difficult for the person experiencing the problem particularly if it recently occurred and the person’s long-term memory is intact. Difficulties with long-term memory can also have problems when language, events or even one’s own identity are affected. For some people the memory loss is temporary but for others, memory impairments are permanent and must be accepted and accommodated as part of the overall...
Source: PediatricEducation.org - March 30, 2020 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

NIDCR's Spring 2020 E-Newsletter
Having trouble viewing this email? View it as a Web page. NIDCR's Spring 2020 E-Newsletter In this issue: NIDCR News Funding Opportunities NIH/HHS News Funding Notices Science Advances Subscribe to NICDR News Grantee News   NIDCR News CDC’s COVID-19 Guidance for Dental Settings  Dental health care personnel can find COVID-19-related information on the CDC’s Division of Oral Health website, which offers guidance and resources for clinics and health care facilities and recommen...
Source: NIDCR Science News - March 27, 2020 Category: Dentistry Source Type: news

Resolving inflammation: Could it prevent memory loss in Down syndrome and Alzheimer's?
(Medical University of South Carolina) Resolvins are lipids that 'resolve' the inflammation that normally follows injury or disease, returning the body back to normal. Therapeutic administration of one such resolvin can halt memory loss in a common preclinical model of Down syndrome, a finding that could also be relevant to memory loss in Alzheimer's disease, report researchers from the Medical University of South Carolina and elsewhere in Glia. This resolvin could enhance the body's ability to heal and resolve inflammation. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 13, 2020 Category: International Medicine & Public Health Source Type: news

Down syndrome abortion ban is going before a federal court
A federal court in Cincinnati will hear complex legal arguments for and against Ohio's Down syndrome abortion ban Wednesday (Source: ABC News: Health)
Source: ABC News: Health - March 11, 2020 Category: Consumer Health News Tags: Health Source Type: news

Down's syndrome: Campaigners say abortions 'need 24-week limit'
Parents whose babies have the condition can currently choose to terminate any time up to the birth. (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - February 24, 2020 Category: Consumer Health News Source Type: news

Major discovery in the genetics of Down syndrome
(University of Montreal) New research highlights the RCAN1 gene's effect on memory and learning. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - February 21, 2020 Category: Biology Source Type: news

Receiving the news of Down syndrome in the era of prenatal testing
(Massachusetts General Hospital) Most of the mothers of a child with Down Syndrome born in the Netherlands between 2010-16 have consciously chosen not to have prenatal testing. This may be considered as an informed choice, as the majority of these mothers felt that a child with DS was welcome in their family. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 19, 2020 Category: International Medicine & Public Health Source Type: news

Atypical Sleep Tied to Language Skills in Neurodevelopmental Disorders
Nighttime sleep duration predicted receptive vocabulary size in Down syndrome, Williams syndrome (Source: The Doctors Lounge - Psychiatry)
Source: The Doctors Lounge - Psychiatry - February 4, 2020 Category: Psychiatry Tags: Neurology, Pediatrics, Psychiatry, Journal, Source Type: news

Atypical Sleep Tied to Language Skills in Neurodevelopmental Disorders
TUESDAY, Feb. 4, 2020 -- In children with fragile X syndrome (FXS), Down syndrome (DS), and Williams syndrome (WS), disrupted sleep may adversely affect language development, according to a study published in the February issue of Research in... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - February 4, 2020 Category: Pharmaceuticals Source Type: news

Federal government backs Ohio on Down syndrome abortion law
The federal government is taking Ohio's side in a lawsuit over the state law prohibiting doctors from performing abortions based on a fetal diagnosis of Down syndrome (Source: ABC News: Health)
Source: ABC News: Health - January 22, 2020 Category: Consumer Health News Tags: Health Source Type: news

Sleep linked to language skills in neurodevelopmental disorders
(Anglia Ruskin University) New research has discovered that Down's syndrome, Fragile X syndrome and Williams syndrome are all linked to sleep disruption in very young children, and that sleep plays a crucial role in the development of these children's language skills. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - January 16, 2020 Category: Biology Source Type: news

The molecule that can AUTAC bad proteins
(Tohoku University) Tohoku University researchers have developed a strategy that could help cells get rid of disease-related debris. Further research could lead to treatments for neurodegenerative and metabolic diseases, Down syndrome, and maybe even aging-related diseases. The findings were published in the journal Molecular Cell. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 27, 2019 Category: International Medicine & Public Health Source Type: news

Some Down syndrome problems reversed in mice
In a mouse model of Down syndrome, blocking a cellular pathway in brain cells improved learning and memory. (Source: NIH Research Matters from the National Institutes of Health (NIH))
Source: NIH Research Matters from the National Institutes of Health (NIH) - November 26, 2019 Category: Consumer Health News Source Type: news

Washington University gets $11.5M grant to study Down syndrome in babies
Washington University School of Medicine has received a five-year, $11.5 million grant from the National Institutes of Health to study brain development in babies with Down syndrome and how it differs from that in other babies. The study hopes this will lead to therapies to counter developmental delays in children with the condition, officials said. The grant is part of a $77 million initiative that started in 2018 to boost basic and clinical research on infants and children with Down syndrome.… (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - November 25, 2019 Category: Biotechnology Authors: Veneta Rizvic Source Type: news

Governor vetoes bill outlawing abortions over Down syndrome
Pennsylvania’s Democratic governor is vetoing a bill that would prohibit abortions because of a prenatal Down syndrome, a day after it passed the Republican-controlled Legislature (Source: ABC News: Health)
Source: ABC News: Health - November 21, 2019 Category: Consumer Health News Tags: Health Source Type: news

Three clinics rapped for misleading pregnant women
Three clinics have been rapped for misleading pregnant women by exaggerating the effectiveness of Down's Syndrome blood tests. The companies charge £650 per test. (Source: the Mail online | Health)
Source: the Mail online | Health - November 20, 2019 Category: Consumer Health News Source Type: news

MU researchers describe catatonia in Down syndrome
(University of Missouri-Columbia) Down syndrome, due to an extra chromosome 21, occurs in 250,000 children and adults in the United States, making it the country's most common chromosomal disorder. Inherited heart defects, thyroid cancer, celiac disease and developmental disabilities are common Down syndrome complications. Only recently has catatonia, a behavioral condition marked by new onset immobility, mutism, withdrawal and other behavioral abnormalities, been recognized in Down syndrome. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 19, 2019 Category: International Medicine & Public Health Source Type: news

Arthritis Risk Underestimated in Children With Down Syndrome Arthritis Risk Underestimated in Children With Down Syndrome
Arthritis can be missed in young people with Down syndrome, who might not effectively communicate their pain, so experts recommend annual screening.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - November 18, 2019 Category: Consumer Health News Tags: Rheumatology News Source Type: news

Most Admired CEO Michelle Sie Whitten's for-profit biz experience informs nonprofit advocacy
Global Down Syndrome Foundation president and CEO was one of DBJ's very first Outstanding Women in Business through her work in the cable industry. (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - November 15, 2019 Category: Biotechnology Authors: Jonathan Rose Source Type: news

In Down Syndrome mouse model, scientists reverse intellectual deficits with drugs
(University of California - San Francisco) In a surprising finding using the standard animal model of Down syndrome (DS), scientists were able to correct the learning and memory deficits associated with the condition -- the leading genetic cause of cognitive disability and the most frequently diagnosed chromosomal disorder in the US -- with drugs that target the body's response to cellular stresses. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - November 14, 2019 Category: Biology Source Type: news

Translating translation in Down syndrome
(Source: ScienceNOW)
Source: ScienceNOW - November 14, 2019 Category: Science Authors: Halliday, M., Mallucci, G. R. Tags: perspective Source Type: news

Activation of the ISR mediates the behavioral and neurophysiological abnormalities in Down syndrome
In this study, we found that the integrated stress response (ISR)—a signaling network that maintains proteostasis—was activated in the brains of DS mice and individuals with DS, reprogramming translation. Genetic and pharmacological suppression of the ISR, by inhibiting the ISR-inducing double-stranded RNA–activated protein kinase or boosting the function of the eukaryotic translation initiation factor eIF2-eIF2B complex, reversed the changes in translation and inhibitory synaptic transmission and rescued the synaptic plasticity and long-term memory deficits in DS mice. Thus, the ISR plays a crucial role ...
Source: ScienceNOW - November 14, 2019 Category: Science Authors: Zhu, P. J., Khatiwada, S., Cui, Y., Reineke, L. C., Dooling, S. W., Kim, J. J., Li, W., Walter, P., Costa-Mattioli, M. Tags: Cell Biology, Neuroscience r-articles Source Type: news

Study: Aging With Down Syndrome Means Huge Alzheimer's Risk
Title: Study: Aging With Down Syndrome Means Huge Alzheimer's RiskCategory: Health NewsCreated: 11/7/2019 12:00:00 AMLast Editorial Review: 11/8/2019 12:00:00 AM (Source: MedicineNet Alzheimer)
Source: MedicineNet Alzheimer - November 8, 2019 Category: Geriatrics Source Type: news

NHS changes guidance on Down's syndrome after accused of 'scaremongering'
Campaigners, including London actress Sally Phillips (pictured with her son Olly, 15) have now thanked for the NHS for amending the advice, which wasn't due to be revised until April. (Source: the Mail online | Health)
Source: the Mail online | Health - November 5, 2019 Category: Consumer Health News Source Type: news

Down Syndrome Carries Raised Risk of Dementia by 55
Title: Down Syndrome Carries Raised Risk of Dementia by 55Category: Health NewsCreated: 11/4/2019 12:00:00 AMLast Editorial Review: 11/5/2019 12:00:00 AM (Source: MedicineNet Alzheimer)
Source: MedicineNet Alzheimer - November 5, 2019 Category: Geriatrics Source Type: news

People with Down syndrome have trouble using smart speakers. Here's how Google's trying to help
Google and the Canadian Down Syndrome Society have launched a new project that is attempting to teach the tech giant’s systems to better understand people who speak differently. (Source: CBC | Health)
Source: CBC | Health - November 4, 2019 Category: Consumer Health News Tags: News/Canada/Toronto Source Type: news

Down Syndrome Carries Raised Risk of Dementia by 55
MONDAY, Nov. 4, 2019 -- Most people with Down syndrome have dementia by age 55, a new study shows. People with Down syndrome are born with an extra copy of chromosome 21, which often results in developmental disabilities. Surviving to middle age... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - November 4, 2019 Category: General Medicine Source Type: news

Dementia Common in Down Syndrome Patients Aged & #8805;55
MONDAY, Nov. 4, 2019 -- More than half of individuals with Down syndrome aged 55 years or older have dementia claims and 32.7 percent have Alzheimer disease (AD) claims, according to a research letter published online Oct. 28 in JAMA Neurology. Eric... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - November 4, 2019 Category: Pharmaceuticals Source Type: news

Midwife helps with healthy delivery of high-risk child with Down Syndrome
“I had no idea what a midwife was.” Lauren Dantzler isn’t alone. A mother of three, Dantzler had sought out Atrium Health’s Piedmont GYN/OB-Rock Hill during her first pregnancy upon the advice of a friend. She’s since relied on the certified nurse-midwives (CNM) of Atrium Health to deliv er her children, which included a high-risk pregnancy with her youngest son, Copelan. Across four OB/GYN practices, Atrium Health offers midwifery care from 18 experienced midwives. “I sing their praises… (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - November 1, 2019 Category: Biotechnology Authors: Atrium Health Source Type: news

High rates of dementia, Alzheimer ’s observed among older people with Down syndrome
NIH-funded study highlights need for research on aging Down syndrome population. (Source: National Institutes of Health (NIH) News Releases)
Source: National Institutes of Health (NIH) News Releases - October 28, 2019 Category: American Health Source Type: news

Ohio Ban on Down Syndrome Abortion Blocked by U.S. Appeals Court Ohio Ban on Down Syndrome Abortion Blocked by U.S. Appeals Court
A divided federal appeals court on Friday said Ohio cannot enforce a 2017 law banning abortions when medical tests show that a fetus has Down syndrome.Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - October 15, 2019 Category: Consumer Health News Tags: Medscape Today News Source Type: news

Ohio ban on Down syndrome abortion blocked by U.S. appeals court
A divided federal appeals court on Friday said Ohio cannot enforce a 2017 law banning abortions when medical tests show that a fetus has Down syndrome. (Source: Reuters: Health)
Source: Reuters: Health - October 12, 2019 Category: Consumer Health News Tags: healthNews Source Type: news

New NIH grant awards boost funding for research on Down syndrome
INCLUDE project aims to address conditions of Down syndrome and apply knowledge to larger population. (Source: National Institutes of Health (NIH) News Releases)
Source: National Institutes of Health (NIH) News Releases - September 25, 2019 Category: American Health Source Type: news

‘ I Am Worried There Will Be Fewer Of Us, ’ Says Campaigner Against Down Syndrome Test
(CNN) — Natalie Dedreux has spent months campaigning against a plan to make a blood test for Down syndrome free in Germany. While its proponents say the prenatal test is a safer alternative to current procedures and should be available to everyone, Dedreux believes it will lead to people like her being “sorted out.” Dedreux, a 20-year aspiring journalist from Cologne, has the condition. “I am worried that if pregnant women find out their baby has Down syndrome, they will decide against us …. because they are scared,” she wrote on her blog. She has attended protests against the plan and ...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - September 19, 2019 Category: Consumer Health News Authors: Health – CBS Boston Tags: Health News CNN Down Syndrome Source Type: news

'I am worried there will be fewer of us,' says campaigner against Down syndrome test
Natalie Dedreux has spent months campaigning against a plan to make a Down syndrome blood test free in Germany. While its proponents say the prenatal test is a safer alternative to current procedures and should be available to everyone, Dedreux believes it will lead to people like her being "sorted out." (Source: CNN.com - Health)
Source: CNN.com - Health - September 19, 2019 Category: Consumer Health News Source Type: news

'Oldest man' with Down's syndrome loves dancing
George Wildgust, 77, was not expected to live past the age of 10 when he was born. (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - September 11, 2019 Category: Consumer Health News Source Type: news