Planning a Virtual Down Syndrome Cohort Across the Lifespan Workshop (Day 2)
The goal of the workshop “ Planning a Virtual Down Syndrome Cohort Across the Lifespan ” is to develop a plan to meet the goals of INCLUDE Component 2, namely, development of a cohort to perform deep phenotyping and study co-existing conditions to develop a comprehensive genomic, epigenomic, transcriptomic, and proteomic map to help understand the predisposing risk and protective factors that underlie the highly penetrant features in Down syndrome. The INCLUDE (INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE) project was launched in June 2018. We plan to convene an NIH-s...
Source: Videocast - All Events - September 12, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video

Planning a Virtual Down Syndrome Cohort Across the Lifespan Workshop (Day 1)
The goal of the workshop “ Planning a Virtual Down Syndrome Cohort Across the Lifespan ” is to develop a plan to meet the goals of INCLUDE Component 2, namely, development of a cohort to perform deep phenotyping and study co-existing conditions to develop a comprehensive genomic, epigenomic, transcriptomic, and proteomic map to help understand the predisposing risk and protective factors that underlie the highly penetrant features in Down syndrome. The INCLUDE (INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE) project was launched in June 2018. We plan to convene an NIH-s...
Source: Videocast - All Events - September 12, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video

Aneuploidy and Cancer - A Complicated Relationship
NCI's Center for Cancer Research (CCR) Eminent Lecture Dr. Amon received her B.S. and Ph.D. from the University of Vienna. She completed a two-year post-doctoral fellowship with Ruth Lehmann at the Whitehead Institute and was subsequently named a Whitehead Fellow for three years. In 1999, she joined the MIT Koch Institute for Integrative Cancer Research and the Department of Biology where she holds the Kathleen and Curtis Marble Chair for Cancer Research. Dr. Amon ’ s honors include the 2003 Alan T. Waterman Award, the 2007 Paul Marks Prize, the 2008 National Academy of Sciences Molecular Biology Award, and the 2013 ...
Source: Videocast - All Events - October 18, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video

The epigenetic clock, biological age, and chronic diseases
NIH Director’s Wednesday Afternoon Lecture Series It has been a long standing goal to develop molecular biomarkers of biological age. Recent studies demonstrate that powerful epigenetic biomarkers of aging can be defined based on DNA methylation levels. For example, the epigenetic clock (PMID: 24138928) is a multivariate age estimation method that applies to sorted cell types (CD4T cells or neurons), complex tissues, and organs and even prenatal brain samples. The epigenetic clock is an attractive biomarker of aging because a) it applies to most human and chimpanzee tissues, b) its accurate measurement of chronologi...
Source: Videocast - All Events - May 31, 2016 Category: Journals (General) Tags: Upcoming Events Source Type: video