Pathologic and cognitive correlates of plasma biomarkers in neurodegenerative disease

DISCUSSION: Combining plasma biomarkers can optimize detection of Alzheimer's disease (AD) pathology across cognitively normal and clinically diverse neurodegenerative disease.HIGHLIGHTS: Participants were clinically heterogeneous, with autopsy- or biomarker-confirmed Aβ. Combining plasma p-tau181, GFAP, and NfL improved diagnostic accuracy for Aβ status. Diagnosis by plasma biomarkers is more accurate in amnestic AD than nonamnestic AD. Plasma analytes show independent associations with tau PET and post mortem Aβ/tau. Plasma NfL predicted longitudinal cognitive decline in both Aβ+ and Aβ- individuals.PMID:38644682 | DOI:10.1002/alz.13777

Source: The Journal of Alzheimers Association - April 22, 2024 Category: Psychiatry Authors: Katheryn A Q Cousins Jeffrey S Phillips Sandhitsu R Das Kyra O'Brien Thomas F Tropea Alice Chen-Plotkin Leslie M Shaw Ilya M Nasrallah Dawn Mechanic-Hamilton Corey T McMillan David J Irwin Edward B Lee David A Wolk Source Type: research