α-Synuclein seed amplification assay detects Lewy body co-pathology in autosomal dominant Alzheimer's disease late in the disease course and dependent on Lewy pathology burden

DISCUSSION: Results suggest that in ADAD LBP occurs later than AD pathology and often as amygdala- or olfactory-predominant LBP, for which CSF α-synuclein SAA has low sensitivity.HIGHLIGHTS: Cerebrospinal fluid (CSF) real-time quaking-induced conversion (RT-QuIC) detects misfolded α-synuclein in ≈ 10% of symptomatic autosomal dominant Alzheimer's disease (ADAD) patients. CSF RT-QuIC does not detect α-synuclein seeding activity in asymptomatic mutation carriers. Lewy body pathology (LBP) in ADAD mainly occurs as olfactory only or amygdala-predominant variants. LBP develops late in the disease course in ADAD. CSF α-synuclein RT-QuIC has low sensitivity for focal, low-burden LBP.PMID:38666355 | DOI:10.1002/alz.13818

Source: The Journal of Alzheimers Association - April 26, 2024 Category: Psychiatry Authors: Johannes Levin Simone Baiardi Corinne Quadalti Marcello Rossi Angela Mammana Jonathan V öglein Alexander Bernhardt Richard J Perrin Mathias Jucker Oliver Preische Anna Hofmann G ünter U Höglinger Nigel J Cairns Erin E Franklin Patricio Chrem Carlos Cru Source Type: research