Linking white matter hyperintensities to regional cortical thinning, amyloid deposition, and synaptic density loss in Alzheimer's disease

DISCUSSION: Our results suggest that WMH may be associated with AD-intrinsic processes of degeneration, in addition to vascular mechanisms.HIGHLIGHTS: We studied white matter hyperintensities (WMHs) and WMH-connected cortical changes. WMHs are associated with more severe regional cortical degeneration. Findings suggest WMHs may be associated with Alzheimer's disease-intrinsic processes of degeneration.PMID:38648354 | DOI:10.1002/alz.13845

Source: The Journal of Alzheimers Association - April 22, 2024 Category: Psychiatry Authors: Junfang Zhang Haijuan Chen Jie Wang Qi Huang Xiaomeng Xu Wenjing Wang Wei Xu Yihui Guan Jun Liu Joanna M Wardlaw Yulei Deng Fang Xie Binyin Li Source Type: research