Curcumin Suppresses Epithelial Growth Factor Receptor (EGFR) and Proliferative Protein (Ki 67) in Acute Lung Injury and Lung Fibrosis In Vitro and In Vivo.
CONCLUSION: We conclude that curcumin, well-known natural bioactive compound holds strong anti-proliferative on Ki67 and EGFR expressions.We observed that, a clinical outcome in diagnosis of pulmonary fibrosis remains to be unconvincing so far. Curcumin can be considered as a potential therapeutic. PMID: 31441735 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - August 23, 2019 Category: Endocrinology Authors: Shaikh SB, Prabhu A, Bhandary YP Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Comparison the dexamethasone administration effects on post-operative sequelae before and after "third molar" extraction surgeries.
Conclusion Dexamethasone appears to be a promising agent in reduction of post-operative sequelae in third molar surgery. As a potent anti-inflammatory agent it has an effective role in pain, trismus and edema reduction distinguish from the routes of administration, dosage and timing, pre or post-operative prescription. PMID: 31416411 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - August 18, 2019 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Atorvastatin Inhibited ROS Generation and Increased IL-1 β And IL-6 Release by Mononuclear Cells from Diabetic Patients.
CONCLUSION: ATV inhibited ROS generation and activated IL-1 β/IL-6 secretion in PBMNC of diabetes patients. Its effect was not affected by the hyperglymemia. PMID: 31416412 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - August 18, 2019 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Leishmaniasis and autoimmunity in patient with LPS-responsive beige-like anchor protein (LRBA) deficiency.
CONCLUSION: Parasite infections manifestations report in LRBA deficiency. Leishmania infections in patients with chronic diarrhea and autoimmunity should be considered for immunodeficiency. PMID: 31389321 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - August 7, 2019 Category: Endocrinology Authors: Salami F, Shirkani A, Shahrooei M, Azizi G, Yazdani R, Abolhassani H, Aghamohammadi A Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Current status and use of resources of Lysosomal Storage Diseases: Analysis of a Spanish claims database.
CONCLUSIONS: Contrarily to worldwide disease incidence estimations, the group to include Krabbe disease registered the highest occurrence numbers in the study period, which makes evident the need for accurate regional disease incidence and patient demographic studies. Altogether, data suggests the need to improve LSDs diagnostic protocols, and supports the inclusion of these disorders in standard new-born screening programs. PMID: 31389322 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - August 7, 2019 Category: Endocrinology Authors: Josep D, Alicia M Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Dimeric NGF Mimetic Attenuates Hyperglycaemia and DNA Damage in Mice with Streptozotocin-induced Early-stage Diabetes.
CONCLUSION: Early-stage diabetes is accompanied by DNA damage, manifested themselves in the increase of "ghost cells" percentage. The severity of these changes significantly exceeds the degree of hyperglycaemia and MDA accumulation. GK-2 exerts an antihyperglycaemic effect and attenuates the degree of DNA damage. Our results indicate that the comet assay is a highly informative method for the antidiabetic medicines searching. PMID: 31385776 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - August 6, 2019 Category: Endocrinology Authors: Yagubova S, Zhanataev A, Ostrovskaya R, Anisina Е, Gudasheva Т, Durnev А, Seredenin S Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Anticancerous effect of rutin against HPV- C33A cervical cancer cells via G0/G1 cell cycle arrest and apoptotic induction.
CONCLUSION: Thus, our study is envisaged to open up interests for elucidating Rutin as an anti-cancerous agent against cervical cancer. PMID: 31385777 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - August 6, 2019 Category: Endocrinology Authors: Khan F, Pandey P, Upadhyay TK, Jafri A, Jha NK, Mishra R, Singh V Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

A Medullary thyroid cancer with paraganglioma-like pattern diagnosed during pregnancy: A case report and literature revision.
CONCLUSION: Histological diagnosis finally confirmed a rare case of paraganglioma-like MTC (T1 N0 Mx), emphasizing the complexity of our differential diagnosis, between a MTC and a thyroidal paraganglioma. In similar cases, due to a relevant impact on surgical timing, patients should be adequately informed about both risk and benefits of the surgery during pregnancy, and a careful management of the disease is required until and after surgery. PMID: 31376826 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - August 5, 2019 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Key Relevance of Epigenetic Programming of Adiponectin gene in Pathogenesis of Metabolic disorders.
Conclusion: Various studies have postulated that series of factors such as maternal High fat diet (HFD), oxidative stress, pro-inflammatory mediators, sleep fragmentation throughout lifetime, from gestation to old age, could accumulate epigenetic marks, including histone remodeling, DNA methylation, and microRNAs (miRNAs) that, in turn, alter the expression of ADIPOQ gene and results in hypoadiponectinemia which precipitates insulin resistance (IR) that in turn might induce or accelerate the onset and development of metabolic disorder. Better understanding of global patterns of epigenetic modifications and further their ac...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - August 2, 2019 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Aligned Expression of IFI16 and STING Genes in RRMS Patients' Blood.
Abstract OBJECTIVE: Multiple sclerosis (MS) is a chronic neurodegenerative disease of central nervous system. The most common disease phenotype is Relapsing-Remitting MS (RRMS). Beta interferons are the first line of RRMS patients' treatment. Interferon-inducible protein 16 (IFI16) as a DNA sensing molecule and its downstream complex stimulator of interferon genes (STING) play a critical role in the activation of type I interferons. Hence we aimed to evaluate the expression rate of IFI16 and STING in RRMS patients' blood under different type of IFNβ treatment. METHODS: In the present study 99 individuals...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - July 29, 2019 Category: Endocrinology Authors: Helbi S, Ravanbakhsh B, Karimi M, Kooti W, Jivad N Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

UCP2, SHBG, Leptin, and T3 Levels Are Associated with Resting Energy Expenditure in Obese Women.
Authors: Pishva H, Ahmadi S, Eshraghian MR, Hedayati M Abstract OBJECTIVE: The aim of this study was to investigate the association of sex hormone binding globulin (SHBG) with leptin, triiodothyronine (T3), and Uncoupling Protein 2 (UCP2) in obese women with low and normal resting energy expenditure (REE) and to determine the role of these factors in the regulation of REE in obese women. METHOD: A total 49 subjects (25-50 years old) were selected. Anthropometric and body composition parameters and resting energy expenditure were measured. Fasting circulating leptin, T3, SHBG and UCP2 levels were measured. Subje...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - July 26, 2019 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Study of Cord blood Erythropoietin, leptin and adiponectin levels in neonates with Hypoxic Ischemic Encephalopathy.
CONCLUSION AND RECOMMENDATIONS: The significant differences between cord blood erythropoietin, leptin and adiponectin between neonates with hypoxia compared with normal neonates with significantly lower cord blood adiponectin and PH and significantly higher cord blood Leptin and erythropoietin levels in group I compared with group II may arouse our attention about the use of these markers in the cord blood as early predictors of neonatal HIE which can lead early treatment and subsequently better prognosis. PMID: 31345155 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - July 25, 2019 Category: Endocrinology Authors: Hagag AA, El Frargy MS, Abd El-Latif AE Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Clinical Features of Graves' Ophthalmopathy and impact of Enalapril on the Course of Mild Graves' Ophthalmopathy: A pilot study.
CONCLUSION: Our results showed that Enalapril treatment could ameliorate the clinical course of GO according to the ophthalmologic examinations and subjective parameters of disease progression. However, further studies should be performed to determine the efficacy of Enalapril in Graves' ophthalmopathy treatment. PMID: 31345156 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - July 25, 2019 Category: Endocrinology Authors: Ataabadi G, Dabbaghmanesh MH, Owji N, Bakhshayeshkaram M, Montazeri-Najafabady N Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

African walnut (Tetracarpidium conophorum) modulates hepatic lipid accumulation in obesity via reciprocal actions on HMG-CoA reductase and paraoxonase.
CONCLUSION: African walnuts can prevent hepatic lipid accumulation through reciprocal actions on HMG-CoA reductase and paraoxonase in obesity. PMID: 31339080 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - July 24, 2019 Category: Endocrinology Authors: Uti DE, Atangwho IJ, Eyong EU, Umoru GU, Egbung GE, Rotimi SO, Nna VU Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Corrigendum to: The Association of Serum Vitamin D Levels with Pseudoexfoliation Glaucoma/Syndrome.
Authors: Dikci S, Öztürk E, Fırat PG, Yılmaz T, Taşkapan MÇ, Yoloğlu S Abstract In the Original Article by Dikci et al. "The Association of Serum Vitamin D Levels with Pseudoexfoliation Glaucoma/ Syndrome" (Endocr Metab Immune Disord Drug Targets. 2019; 19(2):166-170) after publication of the article it has come to the corresponding author's attention that there were some errors in the article. In the introduction section, reference 3 should be changed as reference 2 (paragraph 1, line 4) and references 4-6 should be changed as references 3-6 (paragraph 1, lines 6,7). Reference number...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - July 20, 2019 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Rituximab Treatment Modulates the Release of Hydrogen Peroxide and the Production of Proinflammatory Cytokines by Monocyte at the Onset of Type 1 Diabetes.
Authors: Hamouda L, Miliani M, Hadjidj Z, Messali R, Aribi M Abstract BACKGROUND: Monocytes are the main blood innate mononuclear phagocyte and one of the most important effector cells expressing Fcγ receptor, which is critical for the interaction with Fc domain of antibodies. OBJECTIVE: To evaluate the effect of Rituximab (RTX, a chimeric human anti-CD20 monoclonal antibody) on the functional activities of Monocytes (MOs) at the onset of human Type 1 Diabetes (T1D). METHODS: MOs were isolated from peripheral blood mononuclear cells (PBMCs) obtained from volunteer patients with recent-onset T1D and he...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - July 20, 2019 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

SRC-3/AIB-1 Enhances Hepatic NFATC1 Transcription and Mediates Inflammation in a Tissue-Specific Manner in Morbid Obesity.
CONCLUSIONS: Steroid receptor coactivators are critical regulators of human metabolism with pleiotropic and tissue-specific actions. We believe that our study will contribute to the better understanding of the complex multi-tissue interactions that are disrupted in obesity and can therefore lead in numerous cardiometabolic diseases. Further on, present findings suggest that SRC-3/AIB-1 could constitute possible future drug targets. PMID: 31322077 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - July 20, 2019 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Differential expression of MARK4 protein and related perturbations in females with ovulatory PCOS.
CONCLUSION: Reduced expression of MARK4 protein in OPCOS increases the associated risk of hyperlipidemia, hyperandrogenism and metabolic syndrome and thus the protein holds strong candidature as a drug target for the syndrome. PMID: 31322078 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - July 20, 2019 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Multi-Target Drugs Against Metabolic Disorders.
Authors: Scotti L, Scotti MT Abstract PMID: 31274061 [PubMed - in process] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - July 6, 2019 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Proteomics screening of differentially expressed cytokines in tears of patients with Graves' ophthalmopathy.
Authors: Song RH, Wang B, Yao QM, Li Q, Jia X, Zhang JA Abstract BACKGROUND: The current study was aimed to explore the cytokine profile in the tears of patients with Graves' ophthalmopathy (GO). METHODS: Approximately 10 ul of tears were sampled from both eyes of each subject using filter paper. Then the levels of up to 34 cytokines in the tears of 7 patients with active GO and 7 healthy volunteers were detected using high-throughput microarray technology in line with the introduction. RESULTS: The results of microarray screening showed that 13 proteins including CD40, CD40 Ligand, GITR, IL-12p70, IL-1 bet...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - June 28, 2019 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Brain Angiotensinergic Regulation of the Immune System: Implications for Cardiovascular and Neuroendocrine Responses.
CONCLUSIONS: Besides the well-known mechanisms by which RAAS activation can lead to the development of hypertension, the interactions between ANG II and the immune system at the brain level can play a significant role. PMID: 31237219 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - June 28, 2019 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

A Historical Review of Persian Medicine Studies into Saliva Manifestations for Potential Applications for Diagnosis and Management of Metabolic Syndrome.
CONCLUSION: saliva manifestations may be as an early symptom of metabolic syndrome and according to WHO's strategy which traditional medicine should be conjugated to conventional medicine, these traditional treatments may be useful. PMID: 31237220 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - June 28, 2019 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Thyroid and eye: Where they meet in clinical practice.
CONCLUSION: Thyroid disorders and eye diseases are interrelated through several mechanisms thus, awareness of this relation is of a great impact on early diagnosis and treatment. PMID: 31237221 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - June 28, 2019 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Thyroid Peroxidase Antibody (TPO) As a Predictor Of Radiation Induced Thyroid Dysfunction Among Nurses And Technicians Working In Mansoura Specialized Medical Hospital: Cross Sectional Study.
CONCLUSION: Already working personnel with positive anti TPO and their TSH levels are more than 1.69 associated with symptoms of hypothyroidism, a trial of treatment is mandatory to relief symptoms. PMID: 31241443 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - June 28, 2019 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Future Perspective of Diabetic Animal Models.
Authors: Pandey S, Dvorakova MC Abstract The need of today's research is to develop successful and reliable diabetic animal models for understanding the disease susceptibility and pathogenesis. The enormous successes of animal models have already been acclaimed for identifying key genetic factors and environmental factors such as Idd loci and effects of microorganisms including the gut microbiota, respectively. Furthermore, animal models have also helped in identifying many therapeutic targets and strategies for immune-intervention. In spite of quite success, we have acknowledged that many of discovered immunothera...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - June 28, 2019 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

The association between HbA1c levels, olfactory memory and cognition in normal, pre-diabetic and diabetic persons.
CONCLUSION: To the best of our knowledge this is the first prospective study to demonstrate a strong association between olfactory dysfunction and specific memory impairment in a population with prediabetes and diabetes suggesting that impaired olfactory identification might play an important role as a specific predictor of memory decline. PMID: 31203811 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - June 14, 2019 Category: Endocrinology Authors: Yulug B, Saatci O, Isiklar A, Hanoglu L, Kilic U, Ozansoy M, Cankaya S, Cankaya B, Kilic E Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Serum D vitamin levels in children with immune thrombocytopenia.
CONCLUSIONS: Its, in our case, may suggest that D vitamin deficiency not represent a chronicity factor for ITP. However, further studies are needed to understand the role of D vitamin in ITP pathogenesis. PMID: 31203812 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - June 14, 2019 Category: Endocrinology Authors: Lassandro G, Carriero F, Palmieri V, Amoruso A, Gallone MF, Del Vecchio GC, Tafuri S, Russo G, Giordano P, Palladino V Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

The potential use of grape phytochemicals for preventing the development of intestine-related and subsequent inflammatory diseases.
CONCLUSION: It is expected the new health food products will be created from grape skins and seeds, since grape phytochemicals participate in the prevention of inflammatory diseases like intestine-related inflammatory diseases. PMID: 31142251 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - June 1, 2019 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Metabolic imbalance and vitamin D deficiency in type 1 diabetes in the Algerian population.
CONCLUSION: Our results indicate that deficiency of VD is associated with increased risk of T1DM in Algerian population. PMID: 31142252 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - June 1, 2019 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Imbalance of steroid hormones in hamsters infected with Schistosoma mansoni.
CONCLUSION: These results indicate that Schistosoma mansoni alters the levels of steroid hormones in infected males and females and it will increase the repertoire of data about host-parasite molecular interplay and its relation with the endocrine system. PMID: 31142253 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - June 1, 2019 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

The association between dyslipidemia and preterm birth: A prospective study in the North of Iran.
Authors: Sharami SH, Gholipour M, Milani F, Kazemnejad E, Heirati SFD, Ranjbar ZA Abstract BACKGROUND: Dyslipidemia is recognized as an important factor in the incidence of preterm birth (PTB). Since the early diagnosis of factors affecting PTB is important in the reduction of maternal-neonatal complications; therefore, we aimed to evaluate the association between dyslipidemia and PTB in women from the Gilan province of Iran. METHOD: The current investigation was a prospective study on 378 pregnant women, during the year 2018-2019, in Rasht city, Gilan province. Samples were randomly selected from among gestati...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - June 1, 2019 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Role of Both Protein C and Antithrombin III as Predictors of stage of liver disease in Chronic Viral Hepatitis B or C Infected patients.
CONCLUSION: Antithrombin III and protein C are natural anticoagulants can be considered as markers of different stages of chronic liver disease. This is supported further by the comparison between the levels of these parameters and clinical stages of liver disease. Protein C is more sensitive than ATIII as marker of hepatocellular damage. PMID: 31142255 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - June 1, 2019 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

The Role of the Status of Selected Micronutrients in Shaping the Immune Function.
CONCLUSION: A diverse diet and regular exposure to sunlight are the best sources for a balanced nutrient supply to maintain an optimal immune defence. PMID: 31142256 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - June 1, 2019 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

The Importance of Precision Medicine in Type 2 Diabetes Mellitus (T2DM): From Pharmacogenetic and Pharmacoepigenetic Aspects.
CONCLUSION: Taken everything into the consideration, there is an extreme need to determine the genetic status of T2DM patients in some known genetic region before planning the medication strategies. PMID: 31122183 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - May 29, 2019 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Women in LOVe: Lacto-Ovo-Vegetarian Diet Rich in Omega-3 Improves Vasomotor Symptoms in Postmenopausal Women. An Exploratory Randomized Controlled Trial.
CONCLUSIONS: After 16 weeks, a lacto-ovo-vegetarian diet rich in omega-3 reduced VMS frequency in postmenopausal women more than the lacto-ovo-vegetarian diet rich in EVO. PMID: 31132980 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - May 29, 2019 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Polymorphism of Secretary PLA2G2A gene is Associated with its Serum level in Type2 Diabetes Mellitus Patients in Northern Iran.
CONCLUSIONS: Our findings demonstrated that serum level of sPLA2 in the patients with T2DM was significantly higher than in healthy subjects. PMID: 31132981 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - May 29, 2019 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

The Prevalence of Allergic Rhinitis among Iranian Children: A Systematic Review and Meta-Analysis.
CONCLUSION: The prevalence of allergic rhinitis is approximately high among Iranian children and adolescents; thus, educational strategies should be considered to decrease the prevalence of this disease in Iran. PMID: 31113353 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - May 14, 2019 Category: Endocrinology Authors: Kalmarzi RN, Ataei P, Pour AF, Behzadifar M, Moradi M, Sharifiyan F, Kalani N, Kooti W Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Diabetes-Induced Proteome Changes Throughout Development.
CONCLUSION: Studying proteome changes in diabetes can deepen our understanding of the biomolecular basis of disease and help us acquire more efficient therapies. PMID: 31038056 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - May 2, 2019 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Comparative Glycaemic Indices of a Four Herbal Combinatorial Formulation Administered On Wistar Rats.
CONCLUSION: The herbs could be useful in the dietary management of diabetes as they could help regulate blood glucose level when consumed with normal meals and could also be incorporated into meals to prevent or delay the onset of diabetes or reverse same in its early stages. PMID: 31038057 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - May 2, 2019 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Incidence of MicroR-4513C/T Gene Variability in Coronary Artery Disease- A case-Control Study.
CONCLUSION: Our study findings indicated that the miR-4513 CT genotype and T allele are associated with increased risk of developing CAD. Furthers studies with larger sample sizes are necessary to confirm this result. PMID: 31038082 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - May 2, 2019 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

No correlation between blood benzene levels and luteinizing hormone plasma values in outdoor workers.
Conclusions: The study did not show a correlation between benzene levels and LH plasma levels in outdoor workers. PMID: 31038083 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - May 2, 2019 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Lepidine B & E as new target inhibitors from Lepidium sativum seeds against four enzymes of the pathogen Candida albicans: in vitro and in silico studies.
CONCLUSION: Through this work, we propose Lepidine B & E as potent antifungal drugs. PMID: 30987578 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - April 17, 2019 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Deltamethrin-induced Immunotoxicity and its protection by Quercetin: An experimental study.
CONCLUSION: Quercetin has strong binding affinity towards CD4, CD8 and CD28, CD45 receptors and protects the thymocytes and splenocytes against DLM-induced apoptotic signaling pathways. PMID: 30968779 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - April 12, 2019 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Evaluation of hs-CRP and sLOX-1 Levels in Moderate-to-High Risk Acute Coronary Syndromes.
CONCLUSION: Vascular inflammation displays the main corner for the onset of ACS and it is related to more complex CAD in these patients. An increase in sLOX-1 expression is closely related to anatomical complexity of CAD in ACS. PMID: 30961517 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - April 10, 2019 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Impaired myocardial MIF/AMPK activation aggravates myocardial ischemia reperfusion injury in high-fat diet-induced obesity.
CONCLUSIONS: An impaired MIF/AMPK activation response and consequent reduced membrane Glut4 expression may play an important role in increasing myocardial susceptibility to I/R in obesity. PMID: 30914037 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - March 28, 2019 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

A brief history of modern endocrinology and definitions of a true hormone.
CONCLUSION: Complex terminology currently used to describe different hormonal actions of chemical messengers, suggest that it is time to conceptualize the term hormone and revise its classical definition. PMID: 30914038 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - March 28, 2019 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Higher levels of serum TLR2 and TLR4 in patients with Hashimoto's Thyroiditis.
CONCLUSION: These findings suggest that TLR-2 and TLR-4 play important role in the immunopathologic mechanism of disease by causing an increase in proinflammatory response. PMID: 30924423 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - March 28, 2019 Category: Endocrinology Authors: Aktaş T, Celik SK, Genc GC, Arpaci D, Can M, Dursun A Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

The Pleiotropic Effects of Statins in Endocrine Disorders.
CONCLUSION: Several aspects of the endocrine system have been shown to be influenced by the pleiotropic effects that statins exert, however, the benefits of statins on cardiovascular morbidity and mortality largely outweigh this deleterious effect, and statin therapy should continue to be recommended. PMID: 30924424 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - March 28, 2019 Category: Endocrinology Authors: De La Cruz JA, Mihos CG, Horvath SA, Santana O Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Sepsis: From Historical Aspects to Novel Vistas. Pathogenic and Therapeutic Considerations.
Authors: Magrone T, Jirillo E Abstract Sepsis is a clinical condition due to an infectious event which leads to an early hyperinflammatory phase followed by a status of tolerance or immune paralysis. Hyper-inflammation derives from a massive activation of immune (neutrophils, monocytes/macrophages, dendritic cells and lymphocytes) and non-immune cells (platelets and endothelial cells) in response to Gram-negative and Gram-positive bacteria and fungi. A storm of pro-inflammatory cytokines and reactive oxygen species accounts for the systemic inflammatory response syndrome. In this phase, bacterial clearance may be a...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - March 14, 2019 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Vitamin D Deficiency, Prevalence and Treatment in Neonatal Period.
Authors: Pediatrician AF Abstract OBJECTIVE: Maternal vitamin D deficiency is an important risk factor that causes infantile rickets in the neonatal and infantile period. The aim of this study was to review the prevalence, clinical characteristics and treatment of vitamin D deficiency andthe follow-upswith infants and their mothers by the neonatal intensive care unit of Afiyet Hospital in Turkey. MATERIALS AND METHODS: Calcium (Ca), phosphorus (P) and 25 (OH) vitamin D were studied and prospectively recorded in infants and their mothers detected to have hypocalcemia during routine biochemistry tests performed o...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - March 14, 2019 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research