Nickel-Induced Damage: Pathogenesis and Therapeutical Approaches.
Authors: Magrone T PMID: 32634087 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - July 8, 2020 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Fixed-Ratio Combinations of Basal Insulin and Glp-1ra in the Management of Type 2 Diabetes Mellitus: Highlight from Literature.
CONCLUSION: FRCs should be considered for safely improve the metabolic control in type 2 diabetic patients. with moderate glycaemic impairment while on oral medications, basal oral regimen or GLP-1RAs. However, a few but significative evidences suggest that FRCs could be a safe and effective treatment instead of a low dose basal-bolus intensification for patients with mild or moderate glucose impairment in order to reduce the risk of hypoglycaemia and unwanted weight gain simplifying the regimen as well. PMID: 32628602 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - July 5, 2020 Category: Endocrinology Authors: Lisco G, De Tullio A, Guastamacchia E, Triggiani V Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

The Association between Apolipoprotein E Polymorphism and Response to Statins in Group of Hyperlipidemic Patients.
CONCLUSIONS: The study showed that there is an association between APOE polymorphism and response to statin therapy. Patients who were APOE ԑ4 carriers had lower response to statins compared to ԑ3 and ԑ2 carriers (p=0.002). In addition we found that there were no significant association between APOE polymorphism and LDL baseline (p=0.214). No significant differences in APOE genotypes distribution between males and females (p=0.06).No significant association was found between age and APOE genotypes (p=0.347). A genotype screening test for dyslipidemic Jordanian patients is recommended to choose the appropriate treatment ...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - July 5, 2020 Category: Endocrinology Authors: Jabr R, Gharaibeh M, Zayed AA, Zihlif M Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Green Synthesis of Copper Oxide Nanoparticles using Cucumis sativus (cucumber) Extracts and their Bio-physical and Biochemical Characterization for Cosmetic and Dermatologic Applications.
CONCLUSION: Our findings have implications for nanoparticle-based cosmetics and dermatologic applications. PMID: 32628604 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - July 5, 2020 Category: Endocrinology Authors: Vats M, Bhardwaj S, Chhabra A Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Genetic Anomalies of Growth Hormone Deficiency in Pediatrics.
Abstract Several different proteins regulate, directly or indirectly, the production of growth hormone from the pituitary gland, thereby complex genetics is involved. Defects in these genes are related to growth hormone deficiency solely, or deficiency of other hormones, secreted from the pituitary gland including growth hormone. These studies can aid clinicians to trace the pattern of the disease between the families, start early treatment and predict possible future consequences. This paper highlights some of the most common and novel genetic anomalies concerning growth hormone, which are responsible for various...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - July 4, 2020 Category: Endocrinology Authors: Firouzi M, Sherkatolabbasieh H, Shafizadeh S Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Roux-en-Y gastrointestinal bypass promotes activation of TGR 5 and peptide YY.
CONCLUSION: Our study suggests that GBP up-regulated the expression of TGR5 in murine intestines, and increased the levels of PYY, which further reduced food intake and decreased the body weight. PMID: 32600238 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - July 1, 2020 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Potential Cytokine Biomarkers in Intellectual Disability.
Authors: Benmakhlouf Y, Zian Z, Nourouti NG, Barakat A, Mechita MB Abstract Intellectual disability (ID), previously called mental retardation, is the most common neurodevelopmental disorder characterized by life-long intellectual and adaptive functioning impairments that have an impact on individuals, families, and society. Its prevalence is estimated to 3% of the general population and its etiology still insufficiently understood. Besides the involvement of genetic and environmental factors, immunological dysfunctions have been also suggested to contribute to the pathophysiology of ID. Over the years, immune biom...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - July 1, 2020 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Ruta montana evokes antihypertensive activity through increase of prosta-glandins release in L-NAME-induced hypertensive rats.
CONCLUSION: The present study illustrates the beneficial action of Ruta montana on hypertension and supports then its use as an antihypertensive agent. PMID: 32600240 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - July 1, 2020 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Cola nitida (Kola Nuts) Attenuates Hepatic Injury in Type 2 Diabetes by Improving Antioxidant and Cholinergic Dysfunctions, and Dysregulated Lipid Metabolism.
CONCLUSION: These data demonstrate the therapeutic effect of C. nitida against diabetic hepatotoxicity in diabetic rats. PMID: 32600241 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - July 1, 2020 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Selenium: A Trace Element for a Healthy Skeleton - A Narrative Review.
Authors: Vescini F, Chiodini I, Palermo A, Cesareo R, De Geronimo V, Scillitani A, Gennari L, Falchetti A Abstract Inadequate serum selenium levels may delay the growth and the physiological changes in bone metabolism. In humans, reduced serum selenium concentrations are associated with both increased bone turnover and reduced bone mineral density. Moreover, a reduced nutritional intake of selenium may lead to an increased risk of bone disease. Therefore, selenium is an essential nutrient playing a role in bone health, probably due to specific selenium-proteins. Some selenium-proteins have an anti-oxidation enzymat...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - July 1, 2020 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Emerging Therapeutic Effects of Herbal Plants in Rheumatoid Arthritis.
Authors: Makkar R, Behl T, Kumar A, Nijhawan P, Arora S Abstract OBJECTIVES: Rheumatoid arthritis is a chronic inflammatory autoimmune disease characterized by failure of spontaneous resolution of inflammation with lifetime perseverance, becoming one of the major causes of disability in millions of people. It is mainly characterized with progressive erosion of cartilage in response to formation of pannus leading to chronic polyarthritis and joint distortion. Early diagnosis and advances in molecular biology undoubtedly revolutionized therapeutic interventions in the past decade for better disease management. Despit...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - June 28, 2020 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Serum Thyroid Peroxidase Antibody Level and Incident Hypertension in Iranian Men: A Suggestion for the Role of Thyroid Autoimmunity.
CONCLUSION: Elevated serum TPO-Ab level can contribute to the development of hypertension among euthyroid men during a long follow-up; suggesting a role for thyroid autoimmunity. PMID: 32579509 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - June 25, 2020 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Spotlight on Circadian Genes and Colorectal Cancer Crosstalk.
Authors: Rajendran S, Barbon S, Pucciarelli S Abstract Mammalian physiology is regulated by circadian clock through oscillating feedback loops controlling cellular processes and behaviors. Recent findings have led to an interesting connection between circadian disruption and colorectal cancer progression and incidence through controlling the hallmarks of cancer namely, cell cycle, cell metabolism and cell death. Deeper understanding of the circadian mechanisms that define the colorectal cancer pathophysiology is the need of the hour to define a chronotherapy for improving colorectal cancer patient survival. This re...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - June 25, 2020 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Phloretin Ameliorates Acetic Acid induced Colitis through Modulation of Immune and Inflammatory Reactions in Rats.
CONCLUSION: Collectively, these findings provide an evidence that phloretin might be useful as a natural therapeutic agent in the management of UC as well as may pose a promising outcome for the future clinical usage. PMID: 32579511 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - June 25, 2020 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

The Influence Of Endothelial Nitric Oxide Synthase (Enos) Genetic Polymorphisms On Cholesterol Blood Levels Among Type 2 Diabetic Patients On Atorvastatin Therapy.
This study investigated the influence of major functional eNOS gene polymorphisms (rs2070744, rs1799983, and rs61722009) on the lipid profile of type 2 diabetes mellitus (T2DM) Jordanian patients treated with atorvastatin. METHODS: The sample comprised 103 T2DM patients who attended the diabetes clinic of Jordan University Hospital. The T2DM patients had regularly been taking 20 mg atorvastatin. The atorvastatin response was calculated by measuring the lipid profile before and after three months of atorvastatin treatment. The eNOS genotypes of the subjects were analyzed using polymerase chain reaction (PCR) followed by...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - June 24, 2020 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Coexistence of Sarcoidosis and Sj ögren's syndrome with hypercalcemia and renal involvement: A case report and literature review.
CONCLUSION: In the literature, calcium metabolic disorder and renal involvement have not been reported among patients with Sarcoidosis and Sjögren's syndrome, suggesting that calcium metabolic disorder may be underestimated. Serum and urine calcium concentration should be measured in addition to routine laboratory test. PMID: 32560621 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - June 21, 2020 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Associations of Yersinia enterocolitica infection with autoimmune thyroid diseases: a systematic review and meta-analysis.
CONCLUSIONS: The current studies suggest that Y. enterocolitica may be associated with the development of AITD. Further study is needed to explore the underlying mechanisms. PMID: 32564766 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - June 21, 2020 Category: Endocrinology Authors: Zangiabadian M, Mirsaeidi M, Pooyafar MH, Goudarzi M, Nasiri MJ Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

A Review on AEG-1 oncogene regulating MicroRNA expression in Colon Cancer progression.
Abstract MicroRNAs (miRS) are a class of small non-coding RNAs which perform a crucial function in posttranscriptional gene regulation. Dysregulation of this microRNAs are associated with many types of cancer progression. In tumorigenesis, downregulated microRNAs might function as tumour suppressor by repressing onco- genes, whereas overexpressed miRs might function as oncogenes by suppressing tumour suppressor. Similarly, Metadherin (also known AEG-1/ LYRIC), is an oncogene, whose levels are found to be very high in various cancers and plays a crucial role in proliferation of cells and invasion. Our review focuse...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - June 17, 2020 Category: Endocrinology Authors: Malayaperumal S, Sriramulu S, Jothimani G, Banerjee A, Pathak S Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Clinical, Immunologic, and Molecular Spectrum of Patients with Immunodeficiency, Centromeric instability, and Facial anomalies (ICF) syndrome: a Systematic Review.
CONCLUSION: The frequency of diagnosed patients with ICF syndrome has increased. Early diagnosis of ICF is important since immunoglobulin supplementation or allogeneic stem cell transplantation can improve the disease-free survival rate. PMID: 32533820 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - June 13, 2020 Category: Endocrinology Authors: Kiaee F, Zaki-Dizaji M, Hafezi N, Almasi-Hashiani A, Hamedifar H, Sabzevari A, Shirkani A, Zian Z, Jadidi-Niaragh F, Aghamahdi F, Goudarzvand M, Yazdani R, Abolhassani H, Aghamohammadi A, Azizi G Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Effects of a Low Carb Diet and Whey Proteins on Anthropometric, Hematochemical and Cardiovascular Parameters in Subjects with Obesity.
Authors: De Pergola G, Zupo R, Lampignano L, Paradiso S, Murro I, Bartolomeo N, Cecere A, Ciccone MM, Giannelli G, Triggiani V Abstract BACKGROUND: The best way to lose body weight, without using drugs and/or suffering hunger and stress, has not yet been defined. The present study tested a low carbohydrate diet, enriched with proteins, in subjects with overweight and obesity. METHODS: The study enrolled 22 uncomplicated overweight and obese subjects. Several parameters were examined before and after 6 weeks of a lowcarbohydrate diet, enriched with 18 g of whey proteins. Anthropometric (body mass index, waist ci...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - June 11, 2020 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Data analysis-driven precise asthmatic treatment by targeting mast cells.
CONCLUSION: This study presented a unique pulmonary gene profile induced by mast cell engraftment, which could be reversed through blockage of mast cells or inhaled BUD. PMID: 32520694 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - June 11, 2020 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Antihyperglycemic and antihyperlipidemic effects of Lippia citriodora in rats.
CONCLUSION: In conclusion, this study demonstrates the hypoglycemic and antihyperlipidemic effects of LCLAE in rats. PMID: 32520695 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - June 11, 2020 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Lipid profile results after cardiovascular prevention programme: Euroaction model in Spain.
CONCLUSION: The EUROACTION nurse-led CVPRP enabled coronary patients to control lipid profile to the European targets. A large proportion of patients were prescribed statin therapy as cardioprotective medication with favorable changes in medication for coronary patients. To improve the potential for cardiovascular prevention, we need local preventive cardiology programmes adapted to the health policy of individual countries. PMID: 32520696 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - June 11, 2020 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Modified plasma cytokine profile in occupational dermatitis.
CONCLUSION: The recognition of the molecular signatures is very important for an accurate and indisputable diagnosis of occupational contact dermatitis. In workers from paint industry, plasma levels of interleukins 3, 10, 13 and 19, fibroblast growth factor-7, and growth/differentiation factor-15 together with leukemia inducible factor may differentiate subjects with contact dermatitis from those without skin lesions. PMID: 32515314 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - June 7, 2020 Category: Endocrinology Authors: Rascu AM, Otelea MR, Mambet C, Handra C, Neagu AI, Rascu A, Giurcaneanu C, Diaconu CC Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Trend Linking of Multiple System Atrophy : A Scientometric Study.
CONCLUSION: In this study, 6530 articles were retrieved from 1988 to 2018 in three different periods. These articles were drafted by 39,184 authors, 3,865 organizations, 80 countries, and 832 journals. Further, 287 articles with more than 100 citations were found. The global citation score (GCS) was 250,834 times and the average cited times per articles was reported as 3,841. The MSA research field demonstrated a diagram for a chronological period to assess the most relevant themes. Each diagram depended on the sum of documents linked to each research topic. Scientometric analysis of the field of MSA can be regarded as a r...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - June 7, 2020 Category: Endocrinology Authors: Khazaneha M, Osareh F, Shafiee K Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Evaluation of Anti-Diabetic Potential of Corn Silk in High-Fat Diet/Streptozotocin- Induced Type 2 Diabetes Mice Model.
CONCLUSION: These results confirmed the traditionally claimed benefits of corn silk on DM, which suggested that the corn silk possessed the anti-diabetic potential and could be further developed as a cheap and plant-derived agent for the treatment of type 2 diabetes mellitus. PMID: 32504506 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - June 6, 2020 Category: Endocrinology Authors: Sheng L, Chen Q, Di L, Li N Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Significance of and Challenges in Regulating Endocrine Disruptors - How Regulators and Industry can Conquer?
CONCLUSION: Existence of EDs, their impact on living beings and mechanism of influence are like a tangled web, which infuse difficulties in regulating them with conventional mindset. Conquering these challenges necessitates that regulators should join forces amongst themselves, with other institutions operating for environment, with industry sponsors and researchers to achieve success in public health safety. PMID: 32504507 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - June 6, 2020 Category: Endocrinology Authors: Dhiman SK, Dureja H Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

The beneficial effect of physical exercise on inflammatory makers in older individuals.
ero I Abstract Old age is associated with a loss of motor functions and a general progressive decline in cognitive functions. Physical exercise is one of the ways in which inflammatory levels in general can be reduced, and therefore physical exercise can be considered a biological aging decelerator. In this article we examine the relationships between physical exercise and inflammatory markers reported for the different physical exercise protocols that have been used in studies with older individuals, as well as the effects of these regimens. The different types of exercises programmed, and methods used to impleme...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - June 6, 2020 Category: Endocrinology Authors: Gómez-Rubio P, Trapero I Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

The Role of Interferences in the Increasing Incidence of Vitamin D Deficiency.
CONCLUSION: The matrix effect caused by exogenous and endogenous interferences in the blood could be a hidden factor increasing the prevalence of vitamin D deficiency by causing falsely low 25OHD3 values. Suspicious results should be remeasured by a dilution study. PMID: 32496995 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - June 5, 2020 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Are Oxidative Stress and Inflammation Mediators of Bone Loss due to Estrogen Deficiency? A Review of Current Evidence.
Authors: Mohamad NV, Ima-Nirwana S, Chin KY Abstract Osteoporosis is one of the major health issues associated with menopause-related estrogen deficiency. Various reports suggest that the hormonal changes related to menopausal transition may lead to derangement of redox homeostasis and ultimately oxidative stress. Estrogen deficiency and oxidative stress may enhance the expression of genes involved in inflammation. All these factors may contribute, in synergy, to the development of postmenopausal osteoporosis. Previous studies suggest that estrogen may act as an antioxidant to protect the bone against oxidative str...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - June 5, 2020 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Association between Gasdermin A and Gasdermin B polymorphisms and allergic rhinitis amongst Jordanians.
In this study, investigate whether there is an association between GSDMA (rs7212938, T/G) and GSDMB (rs7216389, T/C) at locus 17q21.2 and risk of Allergic Rhinitis among Jordanians. Also we aimed to determine if there is an association between such polymorphisms and the IgE level. METHODS: The study included 112 rhinitis patients and 111 Healthy controls. Gasdermin A (GSDMA) (rs7212938, T/G) and Gasdermin B (rs7216389, T/C) polymorphisms were genotyped using the PCR-RFLP method. RESULTS: On the genotype level, three analysis models were applied namely co-dominant, dominant and recessive genotypes. GSDMB CC genotype...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - June 5, 2020 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Treatment Modalities of Psoriasis: A Focus on requisite for Topical Nanocarrier.
CONCLUSION: For better therapeutic outcome, proper selection of drug moiety with its appropriate administration is the major requisite. With the advent of nanotechnology, the development of nanocarrier for dermatologic application has been successfully demonstrated in positioning the systemically administrated drug into topical targeted delivery. In a nutshell, to achieve successful treatment strategies towards psoriasis, there is a need to focus on the development of stable, non-toxic nanocarrier for topical delivery. Inclusion of the existing orally administered drug moiety into nanocarriers for topical delivery is propo...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - June 5, 2020 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Positive Correlation between Circulating Fetuin A and Severity of Coronary Artery Disease in Military Males.
Authors: Afrisham R, Paknejad M, Ilbeigi D, Sadegh-Nejadi S, Gorgani-Firuzjaee S, Vahidi M Abstract INTRODUCTION: Fetuin-A serves a dual function; its high levels are associated with metabolic syndrome, type 2 diabetes, obesity, insulin resistance, and nonalcoholic fatty liver disease and on the other hand, it serves as a potent inhibitor of vascular ectopic calcification. Because of the opposing findings, the aim of the current study was to investigate serum fetuin-A levels in military personnel males with coronary artery disease (CAD). METHODS: In the case-control study, anthropometric and biochemical paramet...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - June 3, 2020 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

How does Diabetes Impair Penile Tissues during Erectile Dysfunction?
CONCLUSION: The impaired protein synthesis induced by deficient insulin signaling is probably an important cause of the diabetic ED. The improvement of protein synthesis through restoring insulin function may be potentially useful for diabetic ED therapy. PMID: 32473622 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - June 1, 2020 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Gene Therapy for Prostate Cancer: A Review.
CONCLUSIONS: Based on the results of these clinical trials, the application of gene therapy in prostate cancer therapeutics can be satisfactorily established. PMID: 32473623 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - June 1, 2020 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Thrombopoietin Receptor Agonists in Children with Immune Thrombocytopenia: A New Therapeutic Era.
CONCLUSION: Although TPO-RAs long term efficacy and safety still require further investigations, their use is gradually expanding in clinical practice of children with ITP. PMID: 32473624 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - June 1, 2020 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Increased Circulatory Extrarenal 1 α,25-Dihydroxyvitamin D3 in Bilaterally Nephrectomized Rats.
CONCLUSIONS: In conclusion, extrarenal 1,25-D could enter into the systemic circulation and therefore, might have systemic effects besides its autocrin and paracrine functions. PMID: 32473004 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - May 30, 2020 Category: Endocrinology Authors: Dabak M, Dabak DO, Kuloglu T, Baydar E, Bulut H, Ozoner O Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Co-administration of soluble fibres and Lactobacillus casei NCDC19 fermented milk prevents adiposity and insulin resistance via modulation of lipid mobilization genes in diet-induced obese mice.
CONCLUSION: Overall, we demonstrate that co-administration of soluble fibres viz. gum acacia, inulin and L. casei NCDC19 fermented milk exhibited the anti-adiposity effects, improved insulin sensitivity and dyslipidemia in mice via modulation of lipid mobilization genes. PMID: 32452329 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - May 28, 2020 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

A Pre-Post Study of Vitamin D Supplements effects on Urinary megalin: The emerging predictive role of megalin in diabetic nephropathy progression.
This study aimed at testing the effect of vitamin D supplements on urinary megalin levels in diabetic nephropathy (DN) patients with vitamin D hypovitaminosis. METHODS: A sample of 63 participants with vitamin D deficiency with diabetic nephropathy (DN) were enrolled in the pre-post study; urinary megalin levels with various clinical parameters and serum levels of vitamin D3 were measured and compared to the baseline at 3- and 6-month intervals. RESULTS: Interestingly, a supplementation related increase in serum vitamin D3 levels at 3- and 6- month interventions affected a constellation of ameliorations in the DN p...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - May 26, 2020 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Dual Role of microRNAs in Autophagy of Colorectal Cancer.
Authors: Sharma T, Radosevich JA, Mandal CC Abstract Autophagy is an evolutionarily conserved pathway that eliminates unwanted proteins out of the cell and increases cell survival. But dysfunctional autophagy is associated with cancer progression, cellular adaptation, cancer metastasis and makes it an attractive therapeutic target. MicroRNAs (miRNAs) are small single-stranded non-coding RNA molecules that usually bind to 3'UTR of mRNAs. This interaction eventually inhibits protein synthesis by repressing translation and/or by degrading mRNAs. miRNAs play a crucial role in the regulation of autophagy and also behave...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - May 21, 2020 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Nutraceuticals: A Comparative Analysis of Regulatory Framework in Different Countries of the World.
CONCLUSION: The development of well regulated, harmonized and research driven approach can help boost the confidence of consumer in nutraceutical products in the world thereby driving the nutraceutical market. PMID: 32427089 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - May 21, 2020 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Oxytocin Signaling Pathway: From Cell Biology To Clinical Implications.
CONCLUSION: Emerging evidence indicates the involvement of OT system in several pathophysiological mechanisms influencing brain anatomy, cognition, language, sense of safety and trust and maternal behavior, with a possible use of exogenous administered OT in the treatment of specific neuro-psychiatric conditions. Furthermore, it modulates pancreatic β-cell responsiveness and lipid metabolism leading to possible therapeutic use in diabetic and dyslipidemic patients and for limiting and even reversing atherosclerotic lesions. PMID: 32433011 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immun...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - May 19, 2020 Category: Endocrinology Authors: Iovino M, Messana T, Tortora A, Giusti C, Lisco G, Giagulli VA, Guastamacchia E, De Pergola G, Triggiani V Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Potent Antihyperglycemic Effects of an Endemic Plant from Morocco (Matthiola maroccana Coss.) in Normal and Streptozotocin-Induced Diabetic Rats.
The objective of the study was to evaluate the effect of its aqueous extract on blood glucose levels in normal and diabetic rats. METHOD: Single dose (6 hours) and daily oral administration for seven days of the Aerial Part Aqueous Extract (A.P.A.E) of Matthiola maroccana (Coss.) (M. maroccana) at a dose of 20 mg/kg body weight on blood glucose levels both in normal and streptozotocin(STZ)-induced diabetic rats. Furthermore, body weight, oral glucose tolerance test, liver histopathological examination, phytochemical screening, and in vitro antioxidant activity of A.P.A.E were performed in this study. RESULTS: The...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - May 19, 2020 Category: Endocrinology Authors: Amssayef A, Lahrach N, Eddouks M Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

The Cannabis spread throughout the Continents and its therapeutic use in history.
CONCLUSION: Through a detailed analysis of the available resources about the origins of C. sativa we found that its use by ancient civilizations as a source of food and textile fibers dates back over 10,000 years, while its therapeutic applications have been improved over the centuries, from the ancient East medicine of the 2nd and 1st millennium B.C. to the more recent introduction in the Western world after the 1st century A.D. In the 20th and 21th centuries, Cannabis and its derivatives have been considered as a menace and banned throughout the world, but nowadays they are still the most widely consumed illicit drugs al...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - May 19, 2020 Category: Endocrinology Authors: Charitos IA, Gagliano-Candela R, Santacroce L, Bottalico L Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Insights into Transdermal Drug Delivery: Approaches for Redressal of a Burgeoning Issue of Osteoporosis.
Abstract Osteoporosis is a progressive bone disease which remains unnoticed until a fracture occurs. It is more predominant in older age population particularly females due to reduced estrogen levels and ultimately limited calcium absorption. The cost burden of treating osteoporotic fractures is too expensive therefore primary focus should be treatment at an early stage. Most of the marketed drugs are available as oral delivery dosage forms. The complications as well as patient non-compliance limit the use of oral therapy for prolonged drug delivery. Transdermal delivery systems seem to be a promising approach for...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - May 19, 2020 Category: Endocrinology Authors: Zakir F, Kohli K, Ahmad FJ, Iqbal Z, Ahmad A Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Obesity: the New Global Epidemic. Pharmacological Treatment, Opportunities and Limits for Personalized Therapy.
CONCLUSION: The drugs, associated with the standard diet and / or exercise protocols, represent a good therapeutic opportunity to allow not only weight loss but also to reduce the risk of developing diseases caused by obesity, particularly cardiovascular diseases, and to maintain the set objectives over time. However, future research on the pharmacological treatment of obesity should encourage greater personalization of therapy, given the differences in safety, efficacy and response to therapy, in the different subpopulations of patients with obesity. PMID: 32410565 [PubMed - as supplied by publisher] (Source: Endocrin...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - May 16, 2020 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Promising Use Of The New Biologics In The Management Of Drug-Induced Hypersensitivity Reactions: Preliminary Approaches.
Authors: Calogiuri G, Brockow K, Nettis E, Macchia L, Foti C, Vacca A Abstract Biologics are an innovative class of drugs that can selectively influence immunological responses at a cellular level. Although their use is usually restricted to some specific diseases such as autoimmune pathologies and tumors, their "off-label" administration has increased widely in the last years. Drug treatment may induce hypersensitivity reactions which currently lack any gold standard therapy but may be a future field of application for biologics. Agents like anti-IgE (Omalizumab) and Tumor Necrosis Factor-α inhibit...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - May 16, 2020 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

A Review on Role of Nanosensors in Detecting Cellular miRNA Expression in Colorectal Cancer.
CONCLUSION: This review may give insight into the different nanostructure like AuNPs, quantum dots, silver nanoparticles, MoS2derived nanoparticles etc. based approach for miRNA detetction using biosensors. PMID: 32410567 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - May 16, 2020 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Combination of naringenin and lisinopril ameliorates nephropathy in Type-1 diabetic rats.
CONCLUSION: Treatment with combination of lisinopril and naringenin showed promising effect in diabetic nephropathy in rats. PMID: 32416710 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - May 16, 2020 Category: Endocrinology Authors: Kulkarni YA, Suryavanshi SV Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Effect of Mirabegron on the Body's Exercise Capacity: A Review.
Abstract Mirabegron is a β3-agonist drug approved by the FDA for use in 2012 and administered in overactive bladder. Activating of adrenergic receptors leads to the relaxation of the detrusor muscle. According to the latest research and reports, it also has lipolytic activity, affecting the reduction of mainly brown adipose tissue (BAT) but also of white adipose tissue (WAT). This results in a decrease in body weight and triglyceride concentration and an increase in lipoprotein lipase activity as well as in the level of free fatty acids or adipokines in the plasma. The drug indirectly participates in the regu...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - May 16, 2020 Category: Endocrinology Authors: Leis K, Mazur E, Racinowski M, Świerczyński W, Baska A, Gałązka P Tags: Endocr Metab Immune Disord Drug Targets Source Type: research