Cannabis Sativa L. Flower and Bud Extracts inhibited In vitro Cholinesterases and b-Secretase Enzymes Activities: Possible Mechanisms of Cannabis use in Alzheimer Disease
CONCLUSION: Therefore, this may explain the mechanism through which AD symptoms may be treated and managed by Cannabis sativa L. extracts.PMID:33618651 | DOI:10.2174/1871530321666210222124349 (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - February 23, 2021 Category: Drugs & Pharmacology Authors: Teboho Mooko Asis Bala Satyajit Tripathy Chethan S Kumar Chandrashekara P Mahadevappa Sushil K Chaudhary Motlalepula G Matsabisa Source Type: research

Cannabis Sativa L. Flower and Bud Extracts inhibited In vitro Cholinesterases and b-Secretase Enzymes Activities: Possible Mechanisms of Cannabis use in Alzheimer Disease
CONCLUSION: Therefore, this may explain the mechanism through which AD symptoms may be treated and managed by Cannabis sativa L. extracts.PMID:33618651 | DOI:10.2174/1871530321666210222124349 (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - February 23, 2021 Category: Endocrinology Authors: Teboho Mooko Asis Bala Satyajit Tripathy Chethan S Kumar Chandrashekara P Mahadevappa Sushil K Chaudhary Motlalepula G Matsabisa Source Type: research

Inflammation and Cancer.
Authors: Venakteshaiah SU, Kumar KH PMID: 33596791 [PubMed - in process] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - February 20, 2021 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Current Understanding of Epigenetics Driven Therapeutic Strategies in Colorectal Cancer Management.
Authors: Deka D, Scarpa M, Das A, Pathak S, Banerjee A Abstract Colorectal cancer is known to be the paramount reason for cancer deaths around the globe. It occurs due to the aggregation of epigenetic and genetic alterations in colon epithelial cells that transmute them into adenocarcinomas. Epigenetic mechanisms are interpreted as the changes in expression of the gene which is not associated with the alterations in the principal DNA sequence, while genetic changes involve modifications in oncogenes and tumor suppressor genes. The changes in the epigenetic in colon cancer that transmute colonic epithelial cells inc...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - February 20, 2021 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Current Understanding of Epigenetics Driven Therapeutic Strategies in Colorectal Cancer Management
Endocr Metab Immune Disord Drug Targets. 2021 Feb 19. doi: 10.2174/1871530321666210219155544. Online ahead of print.ABSTRACTColorectal cancer is known to be the paramount reason for cancer deaths around the globe. It occurs due to the aggregation of epigenetic and genetic alterations in colon epithelial cells that transmute them into adenocarcinomas. Epigenetic mechanisms are interpreted as the changes in expression of the gene which is not associated with the alterations in the principal DNA sequence, while genetic changes involve modifications in oncogenes and tumor suppressor genes. The changes in the epigenetic in colo...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - February 19, 2021 Category: Endocrinology Authors: Dikshita Deka Marco Scarpa Alakesh Das Surajit Pathak Antara Banerjee Source Type: research

Inflammation and Cancer
Endocr Metab Immune Disord Drug Targets. 2021;21(2):193-194. doi: 10.2174/187153032102210105105653.NO ABSTRACTPMID:33596791 | DOI:10.2174/187153032102210105105653 (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - February 18, 2021 Category: Endocrinology Authors: Sathisha Upparahalli Venakteshaiah Kandikattu Hemanth Kumar Source Type: research

Uncovering the Key miRNAs and Targets of the Liuwei Dihuang Pill in Diabetic Nephropathy-Related Osteoporosis based on Weighted Gene Co-Expression Network and Network Pharmacology Analysis.
CONCLUSION: This study demonstrated that miR-574 may play important roles in DNOP, and the therapeutic effects of kaempferol and quercetin on LWD in DNOP might be mediated by miR-574 by targeting MAPK1. Our results provide new perspectives for further studies on the anti-DNOP mechanism of LWD. PMID: 33588742 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - February 17, 2021 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Uncovering the Key miRNAs and Targets of the Liuwei Dihuang Pill in Diabetic Nephropathy-Related Osteoporosis based on Weighted Gene Co-Expression Network and Network Pharmacology Analysis
CONCLUSION: This study demonstrated that miR-574 may play important roles in DNOP, and the therapeutic effects of kaempferol and quercetin on LWD in DNOP might be mediated by miR-574 by targeting MAPK1. Our results provide new perspectives for further studies on the anti-DNOP mechanism of LWD.PMID:33588742 | DOI:10.2174/1871530321666210215161921 (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - February 16, 2021 Category: Endocrinology Authors: Ming Ming Liu Nan Ning Lv Rui Geng Zhen Hua Yong Ma Gui Cheng Huang Jian Cheng Hai Yan Xu Source Type: research

Effect of Direct-Acting Antiviral Drugs on Erectile Functions among Hepatitis C Patients: A Prospective Interventional Study
Endocr Metab Immune Disord Drug Targets. 2021 Feb 12. doi: 10.2174/1871530321666210212143932. Online ahead of print.ABSTRACTBACKGROUND & OBJECTIVE: Erectile dysfunction (ED) is one of the extrahepatic manifestations of hepatitis C virus infection that greatly affects patients' quality of life. Unfortunately, some of the drugs used for HCV treatment may have a negative impact on the patient's erectile function such as the pegylated interferon. Currently, with the introduction of directacting antiviral drugs, there are scarce data in the literature about its potential impact on erectile function. In these settings, we ai...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - February 15, 2021 Category: Endocrinology Authors: Mohamed Alhefnawy Ahmed Mohey Ahmed Fathi Ahmed Mansour Sherief Abd-Elsalam Ahmed Eissa Ayman Hagras Stefano Puliatti Khaled Almekaty Source Type: research

The Role of Angiotensin Converting Enzyme in Immunity: Shedding Light on Experimental Findings
Endocr Metab Immune Disord Drug Targets. 2021 Feb 12. doi: 10.2174/1871530321666210212144511. Online ahead of print.ABSTRACTAngiotensin-converting enzyme (ACE) is a zinc-dependent dicarboxypeptidase with two catalytic components, which has an important role in regulating blood pressure by converting angiotensin I to angiotensin II. ACE breaks down other peptides besides angiotensin I and has a variety of physiological effects together with renal growth and reproduction in men. ACE also acts on innate and acquired immune systems, by affecting macrophage and neutrophil function, and these outcomes are exacerbated due to the ...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - February 15, 2021 Category: Endocrinology Authors: Ziba Aghsaeifard Reza Alizadeh Source Type: research

Appraisal of Anti-Arthritic and Anti-Inflammatory Potential of Folkloric Medicinal Plant Peganum Harmala.
CONCLUSION: It was concluded that P. harmala extract had potential antioxidant, anti-inflammatory and antiarthritic activities which primarily might be attributed to alkaloids, flavonoids and phenols. PMID: 33563161 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - February 12, 2021 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Familial Hypercholesterolemia: Update and Review.
Authors: Camacho OFC, Molina GP, Catalá CFM, Reali JR, Cruz RM, Zenteno JC Abstract Knowledge of epidemiology, genetic etiopathogenesis, diagnostic criteria, and management of familial hypercholesterolemia have increased in the last two decades. Several population studies have shown that familial hypercholesterolemia is more frequent than previously thought, making this entity the most common metabolic disease with monogenic inheritence in the world. Identification of causal heterozygous pathogenic variants in LDLR, APOB, and PCSK9 genes have increased diagnostic accuracy of classical criteria (extreme hyper...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - February 12, 2021 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Dietary Intakes and Food Habits of Wheelchair Basketball Athletes compared to Gym Attendees and Individuals who do not Practice Sport Activity.
CONCLUSIONS: In WBA, commitment to wellness (ON and Med-D adherence) could be a response to gastrointestinal and starvation symptoms. WBA should be involved in setting their own individualized dietary strategies. PMID: 33563163 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - February 12, 2021 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Bioactive Compounds of Polygonatum Sibiricum - Therapeutic Effect and Biological Activity.
Authors: Zhao X, Patil S, Airong Q, Zhao C Abstract Plants serves as an important source of medicinal compounds and their use in various diseases dates back to hundreds of years. One such plant-based compound and the discovery of the antimalarial drug, artemisinin, have significantly brought phytomedicines into the spotlight and have enhanced the understanding and consequently, the application of formulations derived from plants. Traditional Chinese Medicine (TCM), which is based primarily on plants, holds immense potential and is an unexplored source for modern medicine. Many herbs including Polygonatum sibiricum ...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - February 12, 2021 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Effect of Direct-Acting Antiviral Drugs on Erectile Functions among Hepatitis C Patients: A Prospective Interventional Study.
Abstract BACKGROUND & OBJECTIVE: Erectile dysfunction (ED) is one of the extrahepatic manifestations of hepatitis C virus infection that greatly affects patients' quality of life. Unfortunately, some of the drugs used for HCV treatment may have a negative impact on the patient's erectile function such as the pegylated interferon. Currently, with the introduction of directacting antiviral drugs, there are scarce data in the literature about its potential impact on erectile function. In these settings, we aimed to assess the impact of sofosbuvir-based therapy on male erectile function. METHODS: This prospec...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - February 12, 2021 Category: Endocrinology Authors: Alhefnawy M, Mohey A, Fathi A, Mansour A, Abd-Elsalam S, Eissa A, Hagras A, Puliatti S, Almekaty K Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

The Role of Angiotensin Converting Enzyme in Immunity: Shedding Light on Experimental Findings.
Abstract Angiotensin-converting enzyme (ACE) is a zinc-dependent dicarboxypeptidase with two catalytic components, which has an important role in regulating blood pressure by converting angiotensin I to angiotensin II. ACE breaks down other peptides besides angiotensin I and has a variety of physiological effects together with renal growth and reproduction in men. ACE also acts on innate and acquired immune systems, by affecting macrophage and neutrophil function, and these outcomes are exacerbated due to the overexpression of ACE. Over expression of ACE in macrophages imposes antitumor and antimicrobial response,...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - February 12, 2021 Category: Endocrinology Authors: Aghsaeifard Z, Alizadeh R Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

The Effect of HCV Eradication after Direct Acting Antiviral Agents on Hepatic Steatosis: A Prospective Observational Study.
CONCLUSION: Hepatic steatosis is common in HCV Egyptian patients and increases after HCV eradication with DAAs. BMI and CAP values are negatively correlated to hepatic fibrosis regression and positively correlated to steatosis progression one year after DAAs. So, HCV patients with hepatic steatosis may need close follow up for atherosclerotic and HCC risk after DAAs especially if they are overweight. PMID: 33550979 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - February 10, 2021 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Collagen Peptides, in Association with Vitamin C, Sodium Hyaluronate, Manganese and Copper, as Part of the Rehabilitation Project in the Treatment of Chronic Low Back Pain.
CONCLUSIONS: The combination of rehabilitation based on McKenzie back exercises and oral viscosupplementation with Fortigel®, Vitamin C, sodium hyaluronate, manganese and copper represents a valid option in patients with chronic LBP, as it ensures pain relief and improvement in quality of life and in lumbar spine functionality. These therapeutic benefits are more evident and long-lasting compared to those obtained with rehabilitation alone. PMID: 33568038 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - February 10, 2021 Category: Endocrinology Authors: Farì G, Santagati D, Pignatelli G, Scacco V, Renna D, Cascarano G, Vendola F, Bianchi FP, Fiore P, Ranieri M, Megna M Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

The Putative Adverse Effects of Bisphenol A on Autoimmune Diseases.
Abstract Bisphenol A (BPA) is a monomer that is widely used in the manufacture of polycarbonate plastics including storage plastics and baby bottles, and is considered one of the most widely used synthetic compounds in the manufacturing industry. Exposure to BPA mainly occurs after oral ingestion and results from leaks into food and water from plastic containers and according to epidemiological data exposure is widespread and estimated to occur in 90% of individuals. BPA exertspleiotropiceffects and demonstrates estrogen like effects, thus considered an endocrine disrupting chemical. Growing body of evidence highl...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - February 10, 2021 Category: Endocrinology Authors: Sharif K, Kurnick A, Coplan L, Alexander M, Watad A, Amital H, Shoenfeld Y Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Endocrine-Disrupting Compounds in Fish Physiology, with Emphasis on their Effects on the Arginine Vasotocin/Isotocin System.
Authors: Kalamarz-Kubiak H Abstract The purposes of this review are to promote better use of existing knowledge of marine pollutants especially endocrine-disrupting compounds (EDCs) and to draw attention to the slow progression of the research on the influence of those compounds on arginine vasotocin/isotocin system (AVT/IT) in fish. EDCs are leading to the degradation of fish habitats, reducing their spawning potential and possibly their population parameters (e.g. growth, maturation), by preventing fish from breeding and rebuilding their populations. Therefore, searching for new welfare indicators such as AVT and...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - February 4, 2021 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Sofosbuvir/Ledipasvir for Treatment of Chronic Hepatitis C Infection in Adult Patients with β- Thalassemia Major: A Real-Life Study.
CONCLUSION: Sofosbuvir/ledipasvir regimen seems to be safe and highly effective in treatment of chronic HCV in patients with β-thalassemia major. PMID: 33530921 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - February 4, 2021 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Emerging Importance of microRNA in Early Detection of Colorectal Cancer.
Authors: Pathak S, Banerjee A PMID: 33527891 [PubMed - in process] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - February 3, 2021 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Immunopathology of Type 1 Diabetes and Immunomodulatory Effects of Stem Cells: A Narrative Review of the Literature.
Abstract Type 1 Diabetes (T1D) is a complex autoimmune disorder which occurs as a result of an intricate series of pathologic interactions between pancreatic β-cells and a wide range of components of both the innate and the adaptive immune systems. Stem-cell therapy, a recently-emerged potentially therapeutic option for curative treatment of diabetes, is demonstrated to cause significant alternations to both different immune cells such as macrophages, natural killer (NK) cells, dendritic cells, T cells, and B cells and non-cellular elements including serum cytokines and different components of the complement ...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - February 3, 2021 Category: Endocrinology Authors: Tootee A, Nikbin B, Ghahary A, Esfahani EN, Arjmand B, Aghayan H, Qorbani M, Larijani B Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Two Cases of Double Adenomas in a Surgical Series over 16 Years in a Single Centre.
Conclusion Our analysis confirms that DA are rare (0.4 % of the pituitary adenomas) and often asso-ciated with acromegaly. Their pre-operatively diagnosis is difficult but clinician's awareness of DA can improve the diagnosis. The use of pituitary transcription factors could be useful in detecting DA. PMID: 33538680 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - February 3, 2021 Category: Endocrinology Authors: Damiani L, Riccioni L, Nuzzi D, Celico M, Panzacchi R, Ragazzini C, Tosatto L, Nasi MT, Balestrieri A Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Thyroid Diseases During Pregnancy: Bibliometric Analysis of Scientific Publications.
CONCLUSION: The research focus of thyroid diseases in pregnancy ranged from clinical thyroid dysfunction to milder thyroid dysfunction. Guidelines published by the American Thyroid Association enacted a crucial purpose in the treatment and development of thyroid diseases during pregnancy. Some randomized controlled studies of unresolved problems and long-term follow-up of offspring may be the direction of future research. In the meantime, bibliometric methods can help scholars choose journals, track research hotspots, and identify the direction or focus of future research. PMID: 33538681 [PubMed - as supplied by publi...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - February 3, 2021 Category: Endocrinology Authors: Yuan N, Wang L, Li Z, Zhang X Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Association Between Total Bilirubin Levels and Cardio-metabolic Risk Factors Related to Obesity.
CONCLUSION: Among all the studied cardio-metabolic risk factors, HDL-C and NRL are the most closely associated variables with total bilirubin levels in obese adults. PMID: 33511960 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - January 28, 2021 Category: Endocrinology Authors: El-Eshmawy MM, Mahsoub N, Asar M, Elsehely I Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

An Alternative "Trojan Horse" Hypothesis for COVID-19: Immune Deficiency of IL-10 and SARS-CoV-2 Biology.
An Alternative "Trojan Horse" Hypothesis for COVID-19: Immune Deficiency of IL-10 and SARS-CoV-2 Biology. Endocr Metab Immune Disord Drug Targets. 2021 Jan 27;: Authors: Balzanelli MG, Distratis P, Aityan SK, Amatulli F, Catucci O, Cefalo A, De Michele A, Dipalma G, Inchingolo F, Lazzaro R, Nguyen CDK, Palazzo D, Tampoia M, Van PH, Santacroce L, Isacco CG Abstract The coronavirus disease 2019 (COVID-19) pandemic was a challenge for emergency care units worldwide due to the large numbers of patients, the scarcity of information, the medical resources, and the uncertainty regarding the disease...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - January 27, 2021 Category: Endocrinology Authors: Balzanelli MG, Distratis P, Aityan SK, Amatulli F, Catucci O, Cefalo A, De Michele A, Dipalma G, Inchingolo F, Lazzaro R, Nguyen CDK, Palazzo D, Tampoia M, Van PH, Santacroce L, Isacco CG Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Can probiotics supplementation improve glycemic & renal status in Diabetic Nephropathy? A systematic review and meta-analysis of clinical trials.
Can probiotics supplementation improve glycemic & renal status in Diabetic Nephropathy? A systematic review and meta-analysis of clinical trials. Endocr Metab Immune Disord Drug Targets. 2021 Jan 21;: Authors: Tarrahi MJ, Namjoo I, Borzoo-Isfahani M, Ebdali H, Moravejolahkami AR Abstract BACKGROUND & AIMS: This meta-analysis was performed to quantify the effects of probiotics on renal and glycemic biomarkers among patients with Diabetic Nephropathy (DN). METHODS: Electronic databases were searched through May 10, 2020. All trials that investigated the effect of probiotics on serum glycemic ...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - January 23, 2021 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

The relationship between 24-hour indicators and mortality in patients with exertional heat stroke.
CONCLUSION: Patients with EHS often had multiple organ injuries in the early stage (within 24 h), while those cases in the death group were more severe. PMID: 33480352 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - January 22, 2021 Category: Endocrinology Authors: Liu S, Xing L, Wang J, Xin T, Mao H, Zhao J, Li C, Song Q Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Electro-acupuncture Protects diabetic nephropathy-induced inflammation through suppression of NLRP3 inflammasome in Renal macrophage isolation.
CONCLUSIONS: These results suggested that EA protected DN-induced inflammation through suppression of NLRP3 inflammasome. PMID: 33461476 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - January 18, 2021 Category: Endocrinology Authors: Zhang J, Yang X, Zhang X, Lu D, Guo R Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Thyroid Function and Obesity: From Mechanisms to the Benefits of Levothyroxine in Obese Patient.
CONCLUSION: Replacement therapy should be reserved to patients with obvious signs of subclinical or clinical hypothyroidism. DEFINITIONS: Basal metabolic rate (BMR) or basal energy expenditure (BEE): measurement obtained under total inactivity and controlled research conditions; resting energy expenditure (REE): measurement obtained when an individual is sitting quietly (is mildly higher than BMR/BEE). PMID: 33461477 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - January 18, 2021 Category: Endocrinology Authors: De Geronimo V, Cannarella R, La Vignera S Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Bone Disruption and Environmental Pollutants.
CONCLUSION: Taking into account these variables, observational studies are needed to better analyze this issue both for echological purpose and to preserve bone health. PMID: 33461478 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - January 18, 2021 Category: Endocrinology Authors: Giannattasio R, Lisco G, Giagulli VA, Settembrini S, De Pergola G, Guastamacchia E, Lombardi G, Triggiani V Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Negative Correlation between Neuregulin-4 and IL-9 Serum Levels in Patients with Coronary Artery Disease.
CONCLUSION: Our study ،for the first-time, provides the clinical evidence revealing that circulating Nrg4 concentrations are inversely correlated with IL-9 in Iranian patients with CAD, suggesting that the protective role of Nrg4 on atherosclerosis may be, in part, mediated by the proatherogenic cytokine, IL-9. PMID: 33463482 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - January 18, 2021 Category: Endocrinology Authors: Farshidi H, Naderi N, Montazerghaem H, Farshidi N, Rahimzadeh M Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Association between proliferative diabetic retinopathy and serum bile acid level in patients with type 2 diabetes mellitus.
CONCLUSION: Bile acid might be a protective factor for diabetic retinopathy in T2DM, which might be a potential therapeutic role in retinal disorders. PMID: 33438572 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - January 14, 2021 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

The First Case Report of Kabuki Syndrome from the National Iranian Registry of Primary Immunodeficiencies.
Abstract Kabuki syndrome is a rare congenital anomaly/mental retardation syndrome characterized by intellectual disability, developmental delay, short stature, facial dysmorphic features including ectropion of the lateral third of the lower eyelids and long palpebral fissures, and prominent finger pads. Pathogenic variants of KMT2D (MLL2) and KDM6A are found to be the major causes of Kabuki syndrome. Here, we report the first Iranian case with Kabuki syndrome with an IQ of 79, two episodes of viral pneumonia and distinctive facial features, prominent ears and persistent fetal fingertip pads. These characteristics ...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - January 14, 2021 Category: Endocrinology Authors: Safarirad M, Ganji AA, Fekrvand S, Yazdani R, Motlagh AV, Abolhassani H, Aghamohammadi A Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

The Role of Nutrition during the COVID-19 Pandemic: What We Know.
CONCLUSION: A correct lifestyle even including the consumption of nutrient largely present in MD, may be beneficial for preventing or improving prognosis in the SARS-CoV-2 infection. PMID: 33459251 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - January 14, 2021 Category: Endocrinology Authors: Vitale E, Magrone M, Galatola V, Magrone T Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Therapeutic Potential of Poncirin Against Numerous Human Health Complications: Medicinal Uses and Therapeutic Benefit of an Active Principle of Citrus Species.
Authors: Patel DK Abstract Medicinal plants have been used in the indigenous system of medicine for the treatment of numerous human health complications. Medicinal plants were used for the separation and isolation of pure phytochemical and some of the best examples are tubocurarine, aspirin, morphine, digoxin, atropine, quinine and reserpine. Phytoconstituents are pure plant derived natural chemical found to be present in the medicinal plants and examples are flavonoids, alkaloids and phenolic compounds etc. In the modern medicine there is global growth of herbal medicines due to their nutrition, physical effective...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - January 13, 2021 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

High Throughput Study for Molecular Mechanism of Metformin PreDiabetic Protection via Microarray Approach.
CONCLUSION: Collectively, this study has demonstrated a decrease in blood glucose levels and a rise in insulin-levels and thus a consequent prophylactic effects in metformin-given STZ-induced diabetic rats. PMID: 33430738 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - January 11, 2021 Category: Endocrinology Authors: Alrawashdeh AY, Al Shhab MA, Zihlif MA Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Post-Exercise Ketosis, Salivary Uric Acid and Interleukin-6 after a Simulated Wheelchair Basketball Match.
This study aimed to evaluate the post-exercise ketosis, IL-6 and antioxidant response, in WBA of the Italian National team, after a simulated match. METHODS: Dietary intakes, Starvation Symptoms Inventory (SSI), percentage of fat mass (FM%) and basal Respiratory Exchange Ratio (RER) and Basal Energy Expenditure (BEE), were evaluated. Salivary TAC, UA and IL-6 were measured: before (PreM), at the end (EM) and 20 minutes after (PostM) the match. Capillary glucose and β-hydroxybutyrate (βHB) were monitored. Percentage of Heart Rate Reserve (%HRR) was measured to evaluate exercise intensity. RESULTS: WBA ha...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - January 11, 2021 Category: Endocrinology Authors: Raguzzini A, Toti E, Bernardi M, Castellucci F, Cavedon V, Fedullo AL, Milanese C, Sciarra T, Peluso I Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Renal Alterations Induced by Chronic Exposure to Therapeutic Doses of Antihypercholestremic Atorvastatin.
CONCLUSION: The findings of the present work may indicate that ATOR can induce renal histological, histochemical, and ultrastructural alterations that may affect kidney and other vital organ function. PMID: 33413070 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - January 5, 2021 Category: Endocrinology Authors: Al-Doaiss A, Jarrar Y, Shati A, Alfaifi M, Al-Kahtani M, Jarrar B Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Hidden Hunger of Vitamin E Among Healthy College Students: A CrossSectional Study.
CONCLUSION: These results suggest that vitamin E deficiency in college students should be given more attention, and it is necessary to consider using vitamin E supplements. PMID: 33388024 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - January 4, 2021 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Covid-19 In Man: A Very Dangerous Affair.
CONCLUSION: Most data support a role of T as a bivalent risk factor for poor prognosis (high/normal in younger; lower in elderly) in COVID-19. However, the impact of medical treatment aimed to modify T homeostasis for improving the prognosis of affected patients is unknown in this clinical setting. In addition, testicular damage may be a harmful consequence of the infection even in case it occurred asymptomatically but no long-term evidences are currently available to confirm and quantify this phenomenon. Different authors excluded the presence of SARS-CoV-2 in sperm and oocytes, thus limiting worries about both a potentia...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - January 4, 2021 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Curcumin Nanomicelle Improves Lipid Profile, Stress Oxidative Factors and Inflammatory Markers in Patients Undergoing Coronary Elective Angioplasty; A Randomized Clinical Trial.
This study aimed to assess and compare curcumin and nano-curcumin effects on lipid profile, oxidative stress, and inflammatory factors related to patients 'heart. METHOD: This randomized, double-blind, placebo-controlled clinical trial was conducted on 90 patients undergoing coronary elective angioplasty which were randomly divided into 3 groups. The doses administered for 8 weeks were a 500 mg capsule of curcumin daily for the first group and an 80 mg capsule of nano-curcumin for the second group. However, the placebo group received capsules like curcumin. Lipid profile, oxidative stress factors, and inflammatory mar...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - January 4, 2021 Category: Endocrinology Authors: Helli B, Gerami H, Kavianpour M, Heybar H, Hosseini SK, Haghighian HK Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Hypersensitivity to Vitamins with a Focus on Immediate-Type Reactions: Food or Drug Allergy?
Authors: Gianfranco C, Garvey LH, Nettis E, Casciaro F, Alsowaidi S, Foti C, Vacca A Abstract Vitamins are essential substances for normal cell functions, growth, and development. However, they cannot be produced by the human organism, so intake must be through the diet. Vitamin deficiency causes the onset of different diseases, ranging from pellagra to pernicious anemia, which can be corrected by reintroducing the missing vitamin form. To supply the right amount of vitamins to the body, every vitamin naturally occurring in foodstuff has been identified, extracted and synthetically produced, thus allowing either fo...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - December 29, 2020 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Investigation of ACE rs4646994, MTHFR rs1801133 and VDR rs2228570 Genotypes in Jordanian Patients with Fibromyalgia Syndrome.
CONCLUSION: Based on result from this study, it appears that the ACE rs4646994 genotype is associated with restless leg among FMS patients of Jordanian origin. Further clinical investigations with larger sample sizes are required to confirm these findings and to understand the molecular mechanism of ACE rs4646994 genetic variant in the restless leg syndrome among FM patients. PMID: 33357202 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - December 29, 2020 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Zinc supplementation in preterm neonates with jaundice: is it beneficial?
CONCLUSION: Zn administration in jaundiced preterm neonates is beneficial in decreasing serum bilirubin. RECOMMENDATION: Zn supplementation for jaundiced preterm neonates. PMID: 33357203 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - December 29, 2020 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Occurrence of Inborn Errors of Metabolism in newborns, diagnosis and prophylaxis.
Authors: Bharadwaj A, Wahi N, Saxena A Abstract Inborn errors of metabolism (IEM) are heterogeneous group of rare genetic disorders which are generally transmitted as autosomal or X-linked recessive ones. These defects arise due to mutations associated with specific gene(s) especially the ones associated with key metabolic enzymes. These enzymes or their product(s) are involved in various metabolic pathways- leading to accumulation of intermediary metabolite(s), which reflects their toxic effects upon mutations. The diagnosis of these metabolic disorders is based on the biochemical analysis of the clinical manifest...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - December 29, 2020 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Study of Cord Blood Levels of Erythropoietin, Bilirubin and Reticulocyte Count as Early Predictors of Neonatal Hyperbilirubinemia.
CONCLUSION: Cord blood levels of EPO, bilirubin and RC were increased in cases of pathological neonatal hyperbilirubinemia. RECOMMENDATION: Cord blood levels of EPO, bilirubin and RC could be used for early prediction of pathological neonatal hyperbilirubinemia. PMID: 33372885 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - December 29, 2020 Category: Endocrinology Authors: Elfarargy MS, Al-Ashmawy GM, Abu-Risha S, Khattab H Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Taking Advantage of Plant Defense Mechanisms to Promote Human Health. Exploitation of Plant Natural Products for Preventing or Treating Human Disease. Second of Two Parts.
CONCLUSION: Plants are one of the major sources of healthy dietary products, whose exploitation may promote prevention of chronic disease. PMID: 33372886 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - December 29, 2020 Category: Endocrinology Authors: Magrone T, Magrone M, Russo MA, Jirillo E Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

An Overview on COVID-19 and its Effect on Cardiovascular Diseases.
Abstract COVID-19 (Virus named as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)) is a pandemic disease characterized with respiratory infection caused by coronavirus. It has worldwide after an outbreak began in Wuhan, China, in December 2019. SARS-CoV-2 has infected more than 15 million people globally. The disease severity and mortality increased in patients with heart-related comorbidities. Cardiovascular disease patients are more susceptible and infected with SARS-CoV-2. Early screening and managements these patients prevent or ameliorate adverse outcomes. Several treatments have been used to com...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - December 28, 2020 Category: Endocrinology Authors: Hamadi A, Mahzari A, Hakami A, Hindawi S, Dobie G, Sayyed MI, Hamdi F, Nahari M, Jackson DE Tags: Endocr Metab Immune Disord Drug Targets Source Type: research