Death due to COVID-19 in an Infant with Combined Immunodeficiencies.
Authors: Ahanchian H, Moazzen N, Joghatayi SH, Saeidinia A, Khoshkhui M, Aelami MH, Rezaei N, Haghi NSM Abstract Novel coronavirus disease 2019 (COVID-19) has affected millions of people, which led to death especially in older cases with underlying diseases. Meanwhile pediatric patients with inherited defects of T cell should potentially be prone to viral diseases. Herein, we report an infant with combined immunodeficiency who died because of COVID-19. PMID: 33087035 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - October 23, 2020 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

A case-control study investigating the effect of MTHFR C677T variant on performance of elite athletes.
CONCLUSION: Our findings support that there is an association between the MTHFR C677T C allele and athletic performance among the elite Turkish athletes. PMID: 33092515 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - October 22, 2020 Category: Endocrinology Authors: Nursal AF, Yigit S, Rustemoglu H, Cenikli A Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Berberine in the treatment of diabetes mellitus: a review.
Abstract Berberine is an alkaloid found in plants. It has e.g. neuroprotective, anti-inflammatory and hypolipidemic activity. The research proves that it also strongly impacts the carbohydrate metabolism. The compound also protects pancreatic βcells and increases sensitivity to insulin in peripheral tissues via the induction of GLUT-1, GLUT-4 and insulin type 1 (Ins1) receptors activity. It also stimulates glycolysis and leads to a decrease in insulin resistance by macrophages polarization, lipolytic processes induction and energy expenditure enhancement (by reducing body mass and limiting insulin resistance ...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - October 22, 2020 Category: Endocrinology Authors: Baska A, Leis K, Gałązka P Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Comparison of Salivary Antioxidants and Oxidative Stress Status in Gestational Diabetes Mellitus and Healthy Pregnant Women.
CONCLUSION: Catalase level was significantly lower and total oxidative stress was significantly higher. These two markers might have significant importance and might exhibit early changes compared to other factors in GDM. . Some of salivary antioxidants might have diagnostic, prognostic or therapeutic implications in GDM. Other studies with large sample size on salivary and blood samples need to be done to confirm this properties and salivary samples using instead of blood samples in GDM biomarkers changes. PMID: 33092517 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - October 22, 2020 Category: Endocrinology Authors: Ahmadi-Motamayel F, Fathi S, Goodarzi MT, Borzouei S, Poorolajal J, Barakian Y Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Can Cytokines be used as an Activation Marker in Rheumatoid Arthritis?
CONCLUSION: TNF-R can be the main pathophysiological factor and a marker showing activation. TNF-R can be very important in revealing the effect of TNF on the disease and the value of this effect in the treatment and ensuring the follow-up of the disease with CRP instead of ESR in activation. PMID: 33076814 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - October 19, 2020 Category: Endocrinology Authors: Kaya FÖ, Ceylaner Y, İpek BÖ, Özünal ZG, Sezgin G, Nalbant S Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

The anti-diabetic effect of some plant extracts against Streptozotocin - induced diabetes type 2 in male albino rats.
CONCLUSION: Both tested herbal extracts performed anti-diabetic effect that mainly could be mechanized via the α-amylaseinhibitory potentials due to the high phenolic and flavonoids content. PMID: 33069202 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - October 16, 2020 Category: Endocrinology Authors: Gomaa HF, Abdelmalek IB, Abdel-Wahhab KG Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Anxiety, Insomnia and Body Mass Index scores in Italian nurses engaged in the care of COVID-19 patients.
Abstract BACKGROUND: A new Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2) (COVID-19) infection was reported in Wuhan, China, and quickly spread, becoming a global health emergency. Literature shows how nursing work is particularly stressful and how this condition is closely connected to the development of anxiety disorders, sleep quality and can also influence eating behavior with consequent variations in BMI values. OBJECTIVE: The study aims to investigate and correlate the levels of anxiety, insomnia and Body Mass Index among nurses directly involved in the care of patients in the intensive care...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - October 16, 2020 Category: Endocrinology Authors: Vitale E, Mea R, Di Dio F, Canonico A, Galatola V Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Prevalence and clinical profile of undiagnosed diabetes mellitus: data from a tertiary hospital.
CONCLUSION: The prevalence of undiagnosed diabetes mellitus is increasing far more than expected. Newly diagnosed diabetic patients usually presented with multiple comorbidities including overweight/obesity, hypertension, and dyslipidaemia. PMID: 33059571 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - October 14, 2020 Category: Endocrinology Authors: Phan HH, Lam HV, Le NT, Le HN, Tran DT, Tran AV, Mai TP, Do MD Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Selenium a cure for autoimmune thyroiditis?
PMID: 33059572 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - October 14, 2020 Category: Endocrinology Authors: Giammanco M, Giammanco MM Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Relationship between endothelial nitric oxide synthetase gene variants and substance use disorder.
CONCLUSION: This study is one of the first studies investigating the relationship between two eNOS gene variants and SUD in our country. Our findings show that eNOS G894T and VNTR variants may be the significant risk factor for SUDs in Turkish subjects. PMID: 33050870 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - October 13, 2020 Category: Endocrinology Authors: Pehlivan S, Aydin PC, Nursal AF, Pehlivan M, Oyaci Y, Yazici AB Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Reversibility of Acute Adrenal Insufficiency after hip Replacement: A Case Series.
CONCLUSIONS: The present finding suggests that patients developing acute adrenal insufficiency after major orthopedic surgery must undergo long-term surveillance, in order to establish if steroid replacement has to be continued, or if it can be safely withdrawn. PMID: 33050871 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - October 13, 2020 Category: Endocrinology Authors: Latina A, Pellegrino M, Chiefari A, Lardo P, Pia A, Reimondo G, Borretta G Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Leptin G-2548A and Leptin Receptor Q223R gene polymorphisms are differently associated with oxidative process in Mexican mestizo and indigenous with obesity.
ntanar-Escorza MA Abstract Leptin levels and oxidative stress are implicated in obesity risk. Reports of association of leptin gene (LEP) and leptin receptor gene (LEPR) polymorphisms with leptin elevation are contradictory in diverse population. Only a few studies report linkage of obesity with biochemical markers and genetic factors. Objetive: The aim of this study was to examine whether plasma lipid peroxidation, antioxidant capability, leptin levels are associate selected LEP -2548 A/G and LEPR Q223R polymorphisms in mestizo and indigenous obesity Mexican population. METHODS: We identified and characteriz...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - October 9, 2020 Category: Endocrinology Authors: Delgadillo-Guzmán D, Sharara-Núñez AI, Pedroza-Escobar D, Castillo-Maldonado I, Quintanar-Escorza MA Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Acute toxicity Analysis and Antidiabetic Effect of the Moroccan Spider Flower (Cleome Arabica L.) in Normal and Sreptozotocin-Induced Diabetic Rats.
CONCLUSION: this study shows that Cleome arabica is partly safe, and its LD50 seems to be greater than 5000 mg/kg. Cleome Arabica has a favorable effect against diabetes which could be due to presence of numerous secondary metabolites and by protection of hepatocytes. PMID: 33030136 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - October 7, 2020 Category: Endocrinology Authors: Amssayef A, Eddouks M Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Conservative Management of a Gestational Hypercalcemia Due to Primary Hyperparathyroidism with Lack of Complications.
CONCLUSION: In absence of guidelines for GPHPT management, its treatment should be individualized. In our case, despite high calcium levels, a conservative treatment with strict monitoring led to positive outcome of pregnancy. PMID: 33030137 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - October 7, 2020 Category: Endocrinology Authors: Di Bari F, Vita R, Marini H, Borrielli I, Lo Re C, Panebianco V, Benvenga S Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

How Much Vitamin D is Too Much? A Case Report and Review of the Literature.
CONCLUSIONS: This case confirms that vitamin D intoxication is possible albeit with a really high dose. The doses used in clinical practice are far lower than these and, therefore, intoxication rarely occurs even in those individuals whose baseline vitamin D serum levels have never been assessed. Repeated measurements of vitamin D are not necessary in patients under standard integrative therapy. However, patients and clinicians should be aware of the potential dangers of vitamin D overdose. PMID: 33030138 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - October 7, 2020 Category: Endocrinology Authors: De Vincentis S, Russo A, Milazzo M, Lonardo A, De Santis MC, Rochira V, Simoni M, Madeo B Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Editorial in the occasion of the 20th anniversary of Endocrine Metabolic Immune Disorders-Drug Targets journal with a kaleidoscopic vision of selected publications.
Abstract Over the past 20 years, Endocrine Metabolic Immune Disorders-Drug Targets (EMIDDT) journal has been covering a broad field of intertwined topics related to pathogenesis, diagnosis and therapy of endocrine, metabolic and immune diseases. At first, the journal publications were restricted to reviews only and, then, original article submissions have also been accepted. Nowadays, EMIDDT represents a successful journal in continuous expansion with 10 issues in 2020 and a current impact factor (IF) equal to 1.973. Moreover, since 2019 EMIDDT is the official journal of the Italian AME (Associazione Medici Endocr...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - October 7, 2020 Category: Endocrinology Authors: Magrone T, Jirillo E Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Prebiotic Carbohydrates for Therapeutics.
Authors: Basavaiah R, Gurudutt PS Abstract The food industry is constantly shifting focus based on prebiotics as health-promoting substrates rather than just food supplements. A prebiotic is ''a selectively fermented ingredient that allows specific changes, both in the composition and/or activity in the gastrointestinal microflora that confers benefits upon host well-being and health." Prebiotics exert a plethora of health-promoting effects, which has lead to the establishment of multimillion food and pharma industries. The following are the health benefits attributed to prebiotics: mineral absorption, better ...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - September 30, 2020 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Antihyperglycemic Effect of the Moroccan Collard Green (Brassica oleracea var. viridis) in Streptozotocin-Induced Diabetic Rats.
Authors: Amssayef A, Eddouks M Abstract AIMS: The aim of the study was to assess the antihyperglycemic activity of Brassica oleracea. BACKGROUND: Collard green or Brassica oleracea var. viridis which belongs to Brassicaceae family is ranked at 10th place of "powerhouse" vegetables, and it is commonly used traditionally for the treatment of diabetes in Morocco. OBJECTIVE: This current investigation aimed to assess the antihyperglycemic capacity of the aqueous extract of Collard green leaves. METHODS: The effect of a single (6 hours) and repeated (seven days of treatment) oral administration of ...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - September 30, 2020 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

"Non-classical" indication for provocative testing of growth hormone: a retrospective cohort study in adult patients under replacement therapy.
CONCLUSIONS: Idiopathic GHD may be unrecognized due to its subtle manifestations and that an extended use of dynamic GH test may reveal such condition. A potential field of investigation could be to identify subsets of patients with clinical conditions caused or worsened by underlying unrecognized GHD. PMID: 32990548 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - September 30, 2020 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Curcumin targets p53-fibrinolytic system in TGF- β1 mediated alveolar epithelial mesenchymal transition in alveolar epithelial cells.
CONCLUSIONS: This study provides the first evidence of the dynamic response of curcumin on TGF-β1 mediated p53- fibrinolytic system during alveolar injury in vitro. PMID: 32990549 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - September 30, 2020 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Evaluation of Serum Ferritin and Anti-Thyroid Peroxidase Antibody Status in Newly Diagnosed Subclinical Cases of Hypothyroidism.
CONCLUSION: Ferritin concentrations were decreased in anti-TPO negative hypothyroidism, but in case of anti-TPO positive hypothyroidism the ferritin concentrations are raised. Hence, hypothyroidism should not always be considered as an iron deficiency state. PMID: 32981513 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - September 24, 2020 Category: Endocrinology Authors: Tiwari R, Saharia GK, Mangaraj M Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Vitamin D Represses the Aggressive Potential of Osteosarcoma.
CONCLUSION: Based on the present results, 1,25(OH)2D by targeting c-Myc and FOXO1 expression displays anti-invasive, anti-migration and anti-proliferative effects on OS cells in vitro. Our findings suggest that effective doses of the 1,25(OH)2D may reduce of the aggressive potential of OS cell line. However, further investigation and clinical trials are needed. PMID: 32955002 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - September 23, 2020 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Combination of Captopril with Gliclazide Decreases Vascular and Renal Complications and Improves Glycemic Control in Rats with Streptozotocin-induced Diabetes Mellitus.
CONCLUSIONS: Captopril showed a promising protective effect against DM vascular complications, at least via nitric oxide modulating effect, antioxidant effect and anti-inflammatory activity that appeared in biochemical and histopathological findings, lipid profile, renal function and architecture improvements. Combining gliclazide with captopril gives an additive effect through enhanced glycemic control and increased anti-oxidant and anti-inflammatory properties above captopril alone. PMID: 32955003 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - September 23, 2020 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Natural Alkaloids and Diabetes Mellitus: A Review.
CONCLUSION: Based on the findings of the present review alkaloids could be used as preventive and curative agents in the case of endocrine disorders, particularly diabetes and could play a promoting function for the discovery of new antidiabetic agents. PMID: 32955004 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - September 23, 2020 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

False positive of 68Ga-DOTATATE PET-CT in a paraganglioma.
We report here a 75-yo woman with an interaortocaval PGL that was diagnosed after hypertensive crisis occurring during the resection of a kidney tumor. 68Ga-DOTATATE PET-CT disclosed pathologic uptake in the abdomen and at the iliac crest. After the resection of the abdominal tumor, with the histological confirmation of PGL, arterial blood pressure and metanephrine levels normalized. Genetic testing was negative. Thereafter, the bone lesion increased in size and became painful, requiring multiple medications. A selective biopsy disclosed a metastatic lesion arising from the renal tumor. The false positive result of 68Ga-DO...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - September 23, 2020 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Tylophora hirsuta (Wall.) extracts ameliorates diabetes associated with inflammation in alloxan induced diabetic rats.
Authors: Razzaque F, Sharif A, Akhtar B, Khan HM, Akhtar MF, Zaib M, Muhammad A, Sohail K, Hamid I, Qaisar N Abstract BACKGROUND: Tylophora hirsuta Wall. has long been used as traditional medicine for the treatment of diabetes. Current study is designed to evaluate the antidiabetic and anti-inflammatory activity of different extracts of aerial parts of Tylophora hirsuta. METHODS: Sequential maceration was conducted to obtain extracts. Total phenolic contents were determined by FolinCiocalteau method. The antioxidant activity was assessed by DPPH free radical scavenging assay. The extracts were tested for its in...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - September 23, 2020 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Lepidium Meyenii Supplemented Diet Modulates Neurobehavioral and Biochemical Parameters in Mice Fed High-Fat-High-Sugar Diet.
CONCLUSION: Dietary supplementation with MACA shows beneficial effects in mitigating the effects of metabolic syndrome on the brain in mice. PMID: 32955007 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - September 23, 2020 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

VNTR variant of eNOS gene and their relation with osteoporosis in postmenopausal Turkish women.
CONCLUSION: Genetic variants are important for our understanding of OP pathogenesis. Although we could not find a relationship between the eNOS VNTR variant and postmenopausal OP, it is important that this study is the first study investigating the relationship between the eNOS gene VNTR variant and OP in Turkish women. PMID: 32957896 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - September 23, 2020 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Maternal Sodium Valproate Exposure Alters NeuroendocrineCytokines and Oxido-inflammatory Axes in Neonatal Albino Rats.
CONCLUSION: Maternal SVP treatment stimulated neonatal stress-brain (HPA) axis, resulted in an oxido-inflammatory state, and disrupted the neuroendocrine-cytokines axis, and generally neonatal health. PMID: 32957897 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - September 23, 2020 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

An intimate alliance of DNA-damage response network with cell-cycle checkpoints amid events of uncontrolled cellular proliferation- a minireview.
Authors: Chatterjee A, Rajarshi K, Khan R, Ghosh H, Kapoor S, Ray S Abstract There is close interdependence between cell survival, cell senescence, events of the cell cycle, apoptosis, malignancy development, and tumor responses to cancer treatment. Intensive studies and elaborate researches have been conducted on the functional aspects of oncogenes, tumor suppressor genes, apoptotic genes, and members guiding cell cycle regulation. These disquisitions have put forward the existence of a highly organized response pathway termed as a DNAdamage response network. The pathways detecting DNA damage and signaling are int...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - September 23, 2020 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

MicroRNA Expression Levels in Patients with Hashimoto Thyroiditis: A Single Centre Study.
CONCLUSION: miRNAs have important roles at all stages of the diseases. More studies must be performed in all thyroid diseases and autoimmune diseases, including HT. PMID: 32957899 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - September 23, 2020 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Resistance exercise versus aerobic exercise combined with metformin therapy in the treatment of type 2 diabetes: a 12-week comparative clinical study.
CONCLUSIONS: Both resistance and aerobic exercise programs combined with metformin are effective in controlling T2DM. Resistance exercise combined with metformin is more effective than aerobic exercise combined with metformin in the treatment of T2DM. PMID: 32957900 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - September 23, 2020 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Regulation of microRNAs in Inflammation-Associated Colorectal Cancer: A Mechanistic Approach.
Abstract The development of colorectal cancer (CRC) is a multi-stage process. The inflammation of the colon as in inflammatory bowel disease (IBD) such as ulcerative colitis (UC) or Crohn's disease (CD) is often regarded as the initial trigger for the development of CRC. Many cytokines such as tumor necrosis factor alpha (TNF-α) and several interleukins (ILs) are known to exert proinflammatory actions, and inflammation initiates or promotes tumorigenesis of various cancers, including CRC through differential regulation of microRNAs (miRNAs/miRs). miRNAs can be oncogenic miRNAs (oncomiRs) or anti-oncomiRs/tum...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - September 16, 2020 Category: Endocrinology Authors: Muthusami S, Ramachandran I, Krishnamoorthy S, Sambandam Y, Ramalingam S, Queimado L, Chaudhuri G, Kumaran RI Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Platelet Count Improvement after Chronic Hepatitis C Treatment among Cirrhotic Patients Who Achieved Sustained Virological Response: Realworld Results from 2186 Patients in Egypt.
This study aimed to assess the changes in platelet counts of patients with liver cirrhosis due to chronic HCV, who achieved sustained virological response (SVR) after taking direct acting antivirals (DAAs) in a large cohort study in Egypt. METHODS: This multicenter observational retrospective study was carried out on 2500 chronic hepatitis C virus (HCV) infected patients who achieved (SVR) after treatment with direct acting antiviral drugs (DAA). HCV infection was confirmed by positive PCR for HCV RNA infection. SVR was defined as a negative PCR test for HCV-RNA 12 weeks after completion of DAA therapy. Platelets coun...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - September 16, 2020 Category: Endocrinology Authors: Badawi R, Soliman S, Aboali L, Elkadeem M, Elfert A, Elguindy AMA, Safi Ullah M, Abd-Elsalam S Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Probiotics against viruses; COVID-19 is a paper tiger: A Systematic Review.
CONCLUSION: Based on the evidence, some probiotic strains may be useful in SARS-CoV-2 infection; randomized trials are needed to show the facts. PMID: 32940192 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - September 16, 2020 Category: Endocrinology Authors: Paknahad Z, Moravejolahkami AR Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Role of Thyroid Hormone and Oxidant Stress in Cardiovascular Diseases.
CONCLUSION: Dyslipidemia, oxidant-stress in association with T3 augment cardiac-pathogenesis. PMID: 32940193 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - September 16, 2020 Category: Endocrinology Authors: Khan M, Mukherjee S, Bank S, Maiti S Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Role of inflammation in the development of colorectal cancer.
Authors: Muthusami S, Kumaran RI, Babu KN, Krishnamoorthy S, Guruswamy A, Queimado L, Chaudhuri G, Ramachandran I Abstract Chronic inflammation can lead to the development of many diseases including cancer. Inflammatory bowel disease (IBD) that includes both ulcerative colitis (UC) and Crohn's disease (CD) are risk factors for the development of colorectal cancer (CRC). Many cytokines produced primarily by the gut immune cells either during or in response to localized inflammation in the colon and rectum are known to stimulate the complex interactions between the different cell types in the gut environment resultin...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - September 10, 2020 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Vasorelaxant and Antihypertensive Effects of Mentha pulegium L. in Rats: An in vitro and in vivo Approach.
CONCLUSION: The results demonstrate that the extract of pennyrile exhibits antihypertensive activity. In addition, the effect may be, at least in part, due to dilation of blood vessels via blockage of Ca2+ channels. PMID: 32901591 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - September 10, 2020 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Increased Rates of Coronary Artery Calcium Score in Patients with NonFunctioning Adrenal Incidentalomas.
Abstract AIM: We evaluated cardiovascular (CV) risk stratification for nonfunctioning adrenal incidentalomas (NFAIs) via the coronary-artery-calcium (CAC) score. Materials and methods: The participants were patients with an NFAI (n = 55). They were compared to patients with chest pain, a low-intermediate Framingham-risk score and a non-diagnostic treadmill-exercise test, which served as the control group (n = 49). Subsequently, the NFAI group was subdivided according to a CAC score of
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - September 9, 2020 Category: Endocrinology Authors: Akkus O, Akkus G, Kaypakli O, Ozturk FK, Gurkan E, Bekler O, Sen F, Yalcin F Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Influence of ESR1 variants on clinical characteristics and fibromyalgia syndrome in Turkish women.
Conclusion: Our results indicate that ESR1 PvuII/XbaI variants are possibly effective in the development of FMS and some clinical features. PMID: 32914729 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - September 9, 2020 Category: Endocrinology Authors: Arslan HS, Nursal AF, Inanir A, Karakus N, Yigit S Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Molecular diagnosis and treatment of multiple endocrine neoplasia type 2B in Ethnic Han Chinese.
CONCLUSION: The initial diagnosis of MEN 2B is relatively later, and diagnosed by non-endocrine components is extremely lower. Recognition of MEN 2B and its non-endocrine-related components is still the utmost requirement for a Chinese physician. Combined RET screening and serum calcitonin detection can facilitate early diagnosis. PMID: 32914730 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - September 9, 2020 Category: Endocrinology Authors: Zhang ZW, Guo X, Qi XP Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Vitamin D Receptor Gene Polymorphism and the Risk of Multiple Sclerosis in Azeri Population of Iran.
Abstract BACKGROUND: Multiple sclerosis (MS), a disease of central nervous system (CNS), is associated with damage to the myelin sheath of neurons. It is demonstrated that vitamin D deficiency plays an important role in the development of the disease. Binding of vitamin D to its specific nuclear receptors is way to exert its function. OBJECTIVE: Possible correlation between vitamin D receptor (VDR) gene and MS was evaluated in Azeri population of Iran. METHOD: Different genotypes of Bsml site were determined by using PCR-RFLP method in 148 MS patients and 220 nonrelative healthy controls. RESULTS: I...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - September 9, 2020 Category: Endocrinology Authors: Pourostadi M, Sattarpour S, Poor BM, Asgharzadeh M, Kafil HS, Farhoudi M, Asgharzadeh V, Vegari A, Najafi-Ghalelou N, Rashedi J Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Oxytocin as a Potential Adjuvant against COVID-19 Infection.
This article summarizes the benefits of Oxytocin (OT) in the attenuation of coronavirus infectious disease (COVID-19) pathogenesis. The recent outbreak of COVID-19 has become pandemic with 7,323,761 of infected patients and has created health emergency throughout the world. On the basis of clinical study, COVID-19 shows homology with other coronavirus pathogenesis i.e. inflammation, oxidative stress, and hyper-activation of immune system, results cytokine storm and causes acute lung infection (ALI), acute respiratory distress syndrome (ARDS), and kidney dysfunction. OT is a peptide of nine amino acid, well known anti-infla...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - September 9, 2020 Category: Endocrinology Authors: Thakur P, Shrivastava R, Shrivastava VK Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Molecular evaluation of HIF-1 α gene variation and determination of its frequency, and association with Breast Cancer susceptibility in Saudi Arabia.
Conclusion: A significant association of HIF- 1α-CT heterozygosity and T allele significantly increased the susceptibility and is associated with the metastasis of Breast cancer. Further studies with larger data set and well-designed models are required to validate our findings. PMID: 32914726 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - September 8, 2020 Category: Endocrinology Authors: Mir R, Abu-Duhier FM, Albalawi IA Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Berberine as Potential Multi-Target Agent for Metabolic Diseases: A Review of Investigations for Berberine.
Abstract Berberine (BBR) is a botanic alkaloid extracted from Coptis chinensis (Huanglian), which has various properties, compassing anti-hyperglycemia, anti-obesity, anti-inflammation, and improve insulin resistance, etc. Several researches have confirmed that BBR has effective actions in treating glycolipid metabolic abnormalities. BBR also has beneficial in regulating intestinal flora. Metabolic diseases are strongly associated with metabolic disorders, which are growing in the population and dramatically impacting human health, which also have been considered as a leading cause of diseases and death globally. ...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - September 8, 2020 Category: Endocrinology Authors: Wang S, Xu Z, Cai B, Chen Q Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Benfotiamine reduces dendritic cell inflammatory potency.
CONCLUSION: Having in mind the importance of dendritic cells for the configuration of the immune response, our results imply that benfotiamine has the ability to regulate the immune response through inhibition of inflammatory properties of dendritic cells. PMID: 32888286 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - September 4, 2020 Category: Endocrinology Authors: Djedovic N, Božić I, Miljković Đ, Lavrnja I Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Coronaviruses and Endocrine System: a Systematic Review on Evidences and Shadows.
Abstract Coronaviruses are a big family of viruses that can infect mammalians and birds. In humans they mainly cause respiratory tract infections, with a large spectrum of severity, from mild, self-limited infections to highly lethal forms as severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS-CoV) and Coronavirus Disease 2019 (COVID-19). Scanty data are reported for the involvement of endocrine glands by human coronaviruses, in particular SARS-CoV-2. In this review we summarize endocrinological involvement by human coronaviruses, including data on animal co...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - September 4, 2020 Category: Endocrinology Authors: Parolin M, Parisotto M, Zanchetta F, Sartorato P, De Menis E Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Macrovascular Protecting Effects of Berberine through Anti-inflammation and Intervention of BKCa in Type 2 Diabetes Mellitus Rats.
CONCLUSIONS: Protective effects of berberine against macrovascular complications induced by diabetes mellitus may be attributed to inhibiting the inflammation and intervening the calcium-activated potassium (BKCa). PMID: 32888284 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - September 3, 2020 Category: Endocrinology Authors: Wu Z, Gu L, Si Y, Yin W, Zhao M, Zhang T, Chen M Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

The interaction Between Arachidonic Acid Metabolism and Homocysteine.
CONCLUSIONS: We believe that by targeting Hcy in AA pathways, novel compounds with better pharmacological and pharmacodynamics benefits may be obtained and that this information is valuable for dietician to manipulate diets to improve health. PMID: 32888285 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - September 3, 2020 Category: Endocrinology Authors: Domi E, Hoxha M, Hoxha B, Zappacosta B Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Venoms and poisonings during the centuries. A narrative review.
Abstract Suffice it to say that the first traces of its use by man date back to ten thousand years ago the venom or poison since the last period of the Paleolithic man used poison to hunt and for defence. Indeed, in the second half of the 19th century, was found in some caves arrows made from the bones of animals characterized by particular grooves. In ancient Greece, the term pharmakon (φάρμακον) had a double meaning: remedy for therapy and venom. This is the period in which we become aware of the fact that a poison cannot be defined only as a substance capable of changing the p...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - September 2, 2020 Category: Endocrinology Authors: Charitos IA, Gagliano-Candela R, Santacroce L, Bottalico L Tags: Endocr Metab Immune Disord Drug Targets Source Type: research