Food for Thought: Is a Personalized Diet the Optimal Preventive Medicine?
Clin Ther. 2022 May 13:S0149-2918(22)00148-5. doi: 10.1016/j.clinthera.2022.04.009. Online ahead of print.NO ABSTRACTPMID:35577601 | DOI:10.1016/j.clinthera.2022.04.009 (Source: Clinical Therapeutics)
Source: Clinical Therapeutics - May 16, 2022 Category: Drugs & Pharmacology Authors: Jill L Maron Source Type: research

Evaluation of the Pharmacokinetic Profile of Ultra Rapid Lispro Administered Subcutaneously at Different Injection Sites
This study compared the pharmacokinetic profile and glucodynamic response of URLi when administered subcutaneously into the abdomen, upper arm, or thigh. An intravenous (IV) bolus administration was included to determine the absolute bioavailability at each injection site.METHODS: In this Phase I, randomized, open-label, 4-period, crossover study, healthy subjects received a single dose of 15 U URLi subcutaneously into the abdomen, upper arm, or thigh, or by intravenous injection. Serum insulin lispro concentrations and glucodynamic response during a 10-hour euglycemic clamp procedure were assessed after URLi administratio...
Source: Clinical Therapeutics - May 16, 2022 Category: Drugs & Pharmacology Authors: Jennifer K Leohr Mary Anne Dellva Elizabeth LaBell David E Coutant Helle Linnebjerg Source Type: research

Reproductive Health and Coronavirus Disease 2019-Induced Economic Contracture: Lessons From the Great Recession
Clin Ther. 2022 May 12:S0149-2918(22)00145-X. doi: 10.1016/j.clinthera.2022.04.006. Online ahead of print.ABSTRACTThe coronavirus disease 2019 (COVID-19) pandemic has magnified disparities in care, including within reproductive health. There has been limited research on the implications of the financial calamity COVID-19 has precipitated on reproductive health, including restricted access to contraception and prenatal care, as well as adverse perinatal outcomes resulting from economic contracture. We therefore examined the Great Recession (the period of economic downturn from 2007-2009 also referred to as the 2008 recessio...
Source: Clinical Therapeutics - May 15, 2022 Category: Drugs & Pharmacology Authors: LeAnn Louis Angela Frankel Asha Ayub Tatum Williamson Ashley Hanes Megan L Evans Source Type: research

Clinical Profile and Sex-Specific Recovery With Cardiac Rehabilitation After Coronary Artery Bypass Grafting Surgery
Clin Ther. 2022 May 12:S0149-2918(22)00141-2. doi: 10.1016/j.clinthera.2022.04.002. Online ahead of print.ABSTRACTBACKGROUND: Cardiac rehabilitation (CR) improves major adverse cardiac outcomes in patients recovering from myocardial infarction. CR influences outcomes through attenuation of cardiac risk factors, lifestyle changes, and biological effects on endothelial function. The clinical profile and sex-specific outcomes with CR after coronary artery bypass grafting (CABG) is less well defined.METHODS: This retrospective cohort study of consecutive patients undergoing elective or urgent CABG was performed between 2014 an...
Source: Clinical Therapeutics - May 15, 2022 Category: Drugs & Pharmacology Authors: Basmah Safdar Makoto Mori Armin Nowroozpoor Arnar Geirsson Gail D'Onofrio Abeel A Mangi Source Type: research

Tolerability and Pharmacokinetics of Single Escalating and Repeated Doses of CN-105 in Healthy Participants
Clin Ther. 2022 May 10:S0149-2918(22)00110-2. doi: 10.1016/j.clinthera.2022.03.006. Online ahead of print.ABSTRACTPURPOSE: CN-105 is an IV, apolipoprotein E-mimetic pentapeptide. Preclinical studies have reported that CN-105 effectively down-regulates neuroinflammatory responses in microglia and mitigates neuronal excitotoxicity following acute brain injury. The CN-105 Phase I and II trials that have been done in the United States have demonstrated that CN-105 was well tolerated in US participants. Thus, the main objective of the present Phase I study was to investigate the tolerability and pharmacokinetic (PK) profiles of...
Source: Clinical Therapeutics - May 13, 2022 Category: Drugs & Pharmacology Authors: Shuya Li Runqi Wangqin Xia Meng Hao Li Yi Wang Haichen Wang Daniel Laskowitz Xia Chen Yongjun Wang Source Type: research

Tolerability and Pharmacokinetics of Single Escalating and Repeated Doses of CN-105 in Healthy Participants
Clin Ther. 2022 May 10:S0149-2918(22)00110-2. doi: 10.1016/j.clinthera.2022.03.006. Online ahead of print.ABSTRACTPURPOSE: CN-105 is an IV, apolipoprotein E-mimetic pentapeptide. Preclinical studies have reported that CN-105 effectively down-regulates neuroinflammatory responses in microglia and mitigates neuronal excitotoxicity following acute brain injury. The CN-105 Phase I and II trials that have been done in the United States have demonstrated that CN-105 was well tolerated in US participants. Thus, the main objective of the present Phase I study was to investigate the tolerability and pharmacokinetic (PK) profiles of...
Source: Clinical Therapeutics - May 13, 2022 Category: Drugs & Pharmacology Authors: Shuya Li Runqi Wangqin Xia Meng Hao Li Yi Wang Haichen Wang Daniel Laskowitz Xia Chen Yongjun Wang Source Type: research

We Are What We Eat: Food as Medicine in Health and Disease
Clin Ther. 2022 May 6:S0149-2918(22)00147-3. doi: 10.1016/j.clinthera.2022.04.008. Online ahead of print.NO ABSTRACTPMID:35534286 | DOI:10.1016/j.clinthera.2022.04.008 (Source: Clinical Therapeutics)
Source: Clinical Therapeutics - May 9, 2022 Category: Drugs & Pharmacology Authors: A Sidney Barritt Source Type: research

Efficacy and Safety of Single Inhaler Triple Therapy Versus Separate Triple Therapy in Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-analysis
This study aimed to compare the efficacy and safety of single inhaler triple therapy and separate triple therapy in the treatment of patients with moderate to severe chronic obstructive pulmonary disease (COPD).METHODS: PubMed, Embase, Web of Science, Cochrane Library, and ClinicalTrials.gov databases were searched, and the search date was set from database inception until February 15, 2022. Randomized controlled trials of single inhaler triple therapy versus separate triple therapy, from which the results related to efficacy and safety profiles were extracted, and the methodologic quality and risk of bias were evaluated.F...
Source: Clinical Therapeutics - May 9, 2022 Category: Drugs & Pharmacology Authors: Liansheng Zhang Xiaoqing Wang Ye Zhang Wenyu Chen Source Type: research

We Are What We Eat: Food as Medicine in Health and Disease
Clin Ther. 2022 May 6:S0149-2918(22)00147-3. doi: 10.1016/j.clinthera.2022.04.008. Online ahead of print.NO ABSTRACTPMID:35534286 | DOI:10.1016/j.clinthera.2022.04.008 (Source: Clinical Therapeutics)
Source: Clinical Therapeutics - May 9, 2022 Category: Drugs & Pharmacology Authors: A Sidney Barritt Source Type: research

Efficacy and Safety of Single Inhaler Triple Therapy Versus Separate Triple Therapy in Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-analysis
This study aimed to compare the efficacy and safety of single inhaler triple therapy and separate triple therapy in the treatment of patients with moderate to severe chronic obstructive pulmonary disease (COPD).METHODS: PubMed, Embase, Web of Science, Cochrane Library, and ClinicalTrials.gov databases were searched, and the search date was set from database inception until February 15, 2022. Randomized controlled trials of single inhaler triple therapy versus separate triple therapy, from which the results related to efficacy and safety profiles were extracted, and the methodologic quality and risk of bias were evaluated.F...
Source: Clinical Therapeutics - May 9, 2022 Category: Drugs & Pharmacology Authors: Liansheng Zhang Xiaoqing Wang Ye Zhang Wenyu Chen Source Type: research

We Are What We Eat: Food as Medicine in Health and Disease
Clin Ther. 2022 May 6:S0149-2918(22)00147-3. doi: 10.1016/j.clinthera.2022.04.008. Online ahead of print.NO ABSTRACTPMID:35534286 | DOI:10.1016/j.clinthera.2022.04.008 (Source: Clinical Therapeutics)
Source: Clinical Therapeutics - May 9, 2022 Category: Drugs & Pharmacology Authors: A Sidney Barritt Source Type: research

Efficacy and Safety of Single Inhaler Triple Therapy Versus Separate Triple Therapy in Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-analysis
This study aimed to compare the efficacy and safety of single inhaler triple therapy and separate triple therapy in the treatment of patients with moderate to severe chronic obstructive pulmonary disease (COPD).METHODS: PubMed, Embase, Web of Science, Cochrane Library, and ClinicalTrials.gov databases were searched, and the search date was set from database inception until February 15, 2022. Randomized controlled trials of single inhaler triple therapy versus separate triple therapy, from which the results related to efficacy and safety profiles were extracted, and the methodologic quality and risk of bias were evaluated.F...
Source: Clinical Therapeutics - May 9, 2022 Category: Drugs & Pharmacology Authors: Liansheng Zhang Xiaoqing Wang Ye Zhang Wenyu Chen Source Type: research

We Are What We Eat: Food as Medicine in Health and Disease
Clin Ther. 2022 May 6:S0149-2918(22)00147-3. doi: 10.1016/j.clinthera.2022.04.008. Online ahead of print.NO ABSTRACTPMID:35534286 | DOI:10.1016/j.clinthera.2022.04.008 (Source: Clinical Therapeutics)
Source: Clinical Therapeutics - May 9, 2022 Category: Drugs & Pharmacology Authors: A Sidney Barritt Source Type: research

Efficacy and Safety of Single Inhaler Triple Therapy Versus Separate Triple Therapy in Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-analysis
This study aimed to compare the efficacy and safety of single inhaler triple therapy and separate triple therapy in the treatment of patients with moderate to severe chronic obstructive pulmonary disease (COPD).METHODS: PubMed, Embase, Web of Science, Cochrane Library, and ClinicalTrials.gov databases were searched, and the search date was set from database inception until February 15, 2022. Randomized controlled trials of single inhaler triple therapy versus separate triple therapy, from which the results related to efficacy and safety profiles were extracted, and the methodologic quality and risk of bias were evaluated.F...
Source: Clinical Therapeutics - May 9, 2022 Category: Drugs & Pharmacology Authors: Liansheng Zhang Xiaoqing Wang Ye Zhang Wenyu Chen Source Type: research

We Are What We Eat: Food as Medicine in Health and Disease
Clin Ther. 2022 May 6:S0149-2918(22)00147-3. doi: 10.1016/j.clinthera.2022.04.008. Online ahead of print.NO ABSTRACTPMID:35534286 | DOI:10.1016/j.clinthera.2022.04.008 (Source: Clinical Therapeutics)
Source: Clinical Therapeutics - May 9, 2022 Category: Drugs & Pharmacology Authors: A Sidney Barritt Source Type: research