Potential Signals of COVID-19 as an Effect Modifier of Adverse Drug Reactions
The objective of this study was to identify potential signals of effect modification of adverse drug reactions by statistical reporting interactions with COVID-19 infection (SRIsCOVID-19) in a large spontaneous reporting database.METHODS: Data from the US Food and Drug Administration Adverse Event Reporting System through the second quarter of 2020 were used. Three-dimensional disproportionality analyses were conducted to identify drug-event-event (DEE) combinations, for which 1 of the events was COVID-19 infection, that were disproportionately reported. Effect size was quantified by an interaction signal score (INTSS) whe...
Source: Clinical Therapeutics - November 2, 2023 Category: Drugs & Pharmacology Authors: Manfred Hauben Eric Hung Yan Chen Source Type: research
Potential Signals of COVID-19 as an Effect Modifier of Adverse Drug Reactions
The objective of this study was to identify potential signals of effect modification of adverse drug reactions by statistical reporting interactions with COVID-19 infection (SRIsCOVID-19) in a large spontaneous reporting database.METHODS: Data from the US Food and Drug Administration Adverse Event Reporting System through the second quarter of 2020 were used. Three-dimensional disproportionality analyses were conducted to identify drug-event-event (DEE) combinations, for which 1 of the events was COVID-19 infection, that were disproportionately reported. Effect size was quantified by an interaction signal score (INTSS) whe...
Source: Clinical Therapeutics - November 2, 2023 Category: Drugs & Pharmacology Authors: Manfred Hauben Eric Hung Yan Chen Source Type: research
Potential Signals of COVID-19 as an Effect Modifier of Adverse Drug Reactions
The objective of this study was to identify potential signals of effect modification of adverse drug reactions by statistical reporting interactions with COVID-19 infection (SRIsCOVID-19) in a large spontaneous reporting database.METHODS: Data from the US Food and Drug Administration Adverse Event Reporting System through the second quarter of 2020 were used. Three-dimensional disproportionality analyses were conducted to identify drug-event-event (DEE) combinations, for which 1 of the events was COVID-19 infection, that were disproportionately reported. Effect size was quantified by an interaction signal score (INTSS) whe...
Source: Clinical Therapeutics - November 2, 2023 Category: Drugs & Pharmacology Authors: Manfred Hauben Eric Hung Yan Chen Source Type: research
Muscle Strength Decline Caused by Eperisone Hydrochloride: A Case Report
Clin Ther. 2023 Oct 30:S0149-2918(23)00395-8. doi: 10.1016/j.clinthera.2023.10.003. Online ahead of print.ABSTRACTA 65-year-old female with thoracic spinal stenosis and incomplete paraplegia underwent T11-T12 posterior thoracic interbody fusion. During postoperative rehabilitation, she experienced thigh pain, involuntary lower limb convulsions, and muscle fatigue. Despite being prescribed eperisone hydrochloride for relief, her muscle strength decreased after 14 doses. This adverse effect, not listed in the latest Chinese medication instructions, subsided 4 days after discontinuation. This case suggests eperisone hydrochlo...
Source: Clinical Therapeutics - November 1, 2023 Category: Drugs & Pharmacology Authors: Junteng Zhu Jiecheng Xiao Jianxiong Hu Jianlin Shen Bai Chen Chengfei Zhao Source Type: research
Global Trends in Atherosclerotic Cardiovascular Disease
Clin Ther. 2023 Oct 30:S0149-2918(23)00383-1. doi: 10.1016/j.clinthera.2023.09.020. Online ahead of print.ABSTRACTPURPOSE: Cardiovascular disease (CVD) is the leading cause of morbidity and mortality, affecting over 523 million people globally. Atherosclerotic diseases, particularly ischemic heart disease (IHD) and stroke, are the primary mediators of CVD burden and trends, with half of CVD deaths attributed to IHD, and another quarter to ischemic stroke. The aim of this review was to provide an overview of world-wide trends in the burden of atherosclerotic CVD.METHODS: A literature review of published studies reporting re...
Source: Clinical Therapeutics - November 1, 2023 Category: Drugs & Pharmacology Authors: Lee Nedkoff Tom Briffa Dawit Zemedikun Saranne Herrington F Lucy Wright Source Type: research
Cost-effectiveness Analysis and Impact on Length of Hospital Stay of the Introduction of Remdesivir as a Treatment Option for Hospitalized Patients With COVID-19 Requiring Supplemental Oxygen in Greece Versus Standard of Care
This study provides good evidence for policymakers on the economic value of remdesivir as a treatment strategy for hospitalized patients moderately and severely infected by the virus who require supplemental oxygen. The results support the use of remdesivir as a first-line antiviral treatment option for hospitalized patients in the Greek national COVID-19 treatment algorithm. However, the model does not incorporate estimates on possible additional hospitalizations or rehabilitations, long-term adverse effects of COVID-19, adverse events of remdesivir, or indirect costs of the disease. Therefore, further research is needed ...
Source: Clinical Therapeutics - November 1, 2023 Category: Drugs & Pharmacology Authors: Kostas Athanasakis Konstantinos Zisis Christos Tsoulas Nikolaos Nomikos Source Type: research
Nirsevimab-alip
Clin Ther. 2023 Oct 30:S0149-2918(23)00386-7. doi: 10.1016/j.clinthera.2023.10.001. Online ahead of print.NO ABSTRACTPMID:37914587 | DOI:10.1016/j.clinthera.2023.10.001 (Source: Clinical Therapeutics)
Source: Clinical Therapeutics - November 1, 2023 Category: Drugs & Pharmacology Authors: Paul Beninger Source Type: research
Muscle Strength Decline Caused by Eperisone Hydrochloride: A Case Report
Clin Ther. 2023 Oct 30:S0149-2918(23)00395-8. doi: 10.1016/j.clinthera.2023.10.003. Online ahead of print.ABSTRACTA 65-year-old female with thoracic spinal stenosis and incomplete paraplegia underwent T11-T12 posterior thoracic interbody fusion. During postoperative rehabilitation, she experienced thigh pain, involuntary lower limb convulsions, and muscle fatigue. Despite being prescribed eperisone hydrochloride for relief, her muscle strength decreased after 14 doses. This adverse effect, not listed in the latest Chinese medication instructions, subsided 4 days after discontinuation. This case suggests eperisone hydrochlo...
Source: Clinical Therapeutics - November 1, 2023 Category: Drugs & Pharmacology Authors: Junteng Zhu Jiecheng Xiao Jianxiong Hu Jianlin Shen Bai Chen Chengfei Zhao Source Type: research
Global Trends in Atherosclerotic Cardiovascular Disease
Clin Ther. 2023 Oct 30:S0149-2918(23)00383-1. doi: 10.1016/j.clinthera.2023.09.020. Online ahead of print.ABSTRACTPURPOSE: Cardiovascular disease (CVD) is the leading cause of morbidity and mortality, affecting over 523 million people globally. Atherosclerotic diseases, particularly ischemic heart disease (IHD) and stroke, are the primary mediators of CVD burden and trends, with half of CVD deaths attributed to IHD, and another quarter to ischemic stroke. The aim of this review was to provide an overview of world-wide trends in the burden of atherosclerotic CVD.METHODS: A literature review of published studies reporting re...
Source: Clinical Therapeutics - November 1, 2023 Category: Drugs & Pharmacology Authors: Lee Nedkoff Tom Briffa Dawit Zemedikun Saranne Herrington F Lucy Wright Source Type: research
Cost-effectiveness Analysis and Impact on Length of Hospital Stay of the Introduction of Remdesivir as a Treatment Option for Hospitalized Patients With COVID-19 Requiring Supplemental Oxygen in Greece Versus Standard of Care
This study provides good evidence for policymakers on the economic value of remdesivir as a treatment strategy for hospitalized patients moderately and severely infected by the virus who require supplemental oxygen. The results support the use of remdesivir as a first-line antiviral treatment option for hospitalized patients in the Greek national COVID-19 treatment algorithm. However, the model does not incorporate estimates on possible additional hospitalizations or rehabilitations, long-term adverse effects of COVID-19, adverse events of remdesivir, or indirect costs of the disease. Therefore, further research is needed ...
Source: Clinical Therapeutics - November 1, 2023 Category: Drugs & Pharmacology Authors: Kostas Athanasakis Konstantinos Zisis Christos Tsoulas Nikolaos Nomikos Source Type: research
Nirsevimab-alip
Clin Ther. 2023 Oct 30:S0149-2918(23)00386-7. doi: 10.1016/j.clinthera.2023.10.001. Online ahead of print.NO ABSTRACTPMID:37914587 | DOI:10.1016/j.clinthera.2023.10.001 (Source: Clinical Therapeutics)
Source: Clinical Therapeutics - November 1, 2023 Category: Drugs & Pharmacology Authors: Paul Beninger Source Type: research
Impact of Gluten-Free Diet on Anthropometric Indicators in Individuals With and Without Celiac Disease: A Systematic Review and Meta-analysis
Clin Ther. 2023 Oct 28:S0149-2918(23)00382-X. doi: 10.1016/j.clinthera.2023.09.018. Online ahead of print.ABSTRACTPURPOSE: Previous studies have found that a gluten-free diet (GFD) may have improve obesity-related factors. For this reason, we conducted a systematic review and meta-analysis to investigate the effect of a GFD on anthropometric indicators.METHODS: We performed a systematic search in databases from inception until July 12, 2022. We included all relevant articles that evaluate efficacy of a GFD on anthropometric indicators in patients with and without celiac disease (CD). Random-effects models were applied to c...
Source: Clinical Therapeutics - October 30, 2023 Category: Drugs & Pharmacology Authors: Chenleng Xin Roya Imanifard Maryam Jarahzadeh Pejman Rohani Periyannan Velu Mohammad Hassan Sohouli Source Type: research
Impact of Gluten-Free Diet on Anthropometric Indicators in Individuals With and Without Celiac Disease: A Systematic Review and Meta-analysis
Clin Ther. 2023 Oct 28:S0149-2918(23)00382-X. doi: 10.1016/j.clinthera.2023.09.018. Online ahead of print.ABSTRACTPURPOSE: Previous studies have found that a gluten-free diet (GFD) may have improve obesity-related factors. For this reason, we conducted a systematic review and meta-analysis to investigate the effect of a GFD on anthropometric indicators.METHODS: We performed a systematic search in databases from inception until July 12, 2022. We included all relevant articles that evaluate efficacy of a GFD on anthropometric indicators in patients with and without celiac disease (CD). Random-effects models were applied to c...
Source: Clinical Therapeutics - October 30, 2023 Category: Drugs & Pharmacology Authors: Chenleng Xin Roya Imanifard Maryam Jarahzadeh Pejman Rohani Periyannan Velu Mohammad Hassan Sohouli Source Type: research
Connecting the Dots: How Injury in the Arterial Wall Contributes to Atherosclerotic Disease
Clin Ther. 2023 Oct 25:S0149-2918(23)00396-X. doi: 10.1016/j.clinthera.2023.10.004. Online ahead of print.ABSTRACTPURPOSE: The occurrence and development of atherosclerotic cardiovascular disease, which can result in severe outcomes, such as myocardial infarction, stroke, loss of limb, renal failure, and infarction of the gut, are strongly associated with injury to the intimal component of the arterial wall whether via the inside-out or outside-in pathways. The role of injury to the tunica media as a pathway of atherosclerosis initiation is an underresearched area. This review focuses on potential pathways to vessel wall i...
Source: Clinical Therapeutics - October 27, 2023 Category: Drugs & Pharmacology Authors: Hanane Belhoul-Fakir Michael Lawrence Brown Peter L Thompson Juliana Hamzah Shirley Jansen Source Type: research
Connecting the Dots: How Injury in the Arterial Wall Contributes to Atherosclerotic Disease
Clin Ther. 2023 Oct 25:S0149-2918(23)00396-X. doi: 10.1016/j.clinthera.2023.10.004. Online ahead of print.ABSTRACTPURPOSE: The occurrence and development of atherosclerotic cardiovascular disease, which can result in severe outcomes, such as myocardial infarction, stroke, loss of limb, renal failure, and infarction of the gut, are strongly associated with injury to the intimal component of the arterial wall whether via the inside-out or outside-in pathways. The role of injury to the tunica media as a pathway of atherosclerosis initiation is an underresearched area. This review focuses on potential pathways to vessel wall i...
Source: Clinical Therapeutics - October 27, 2023 Category: Drugs & Pharmacology Authors: Hanane Belhoul-Fakir Michael Lawrence Brown Peter L Thompson Juliana Hamzah Shirley Jansen Source Type: research
