Intensify Standardized Anticoagulation for Cancer-Associated Pulmonary Embolism: From Single-Center Real-World Data
Clin Ther. 2023 Oct 12:S0149-2918(23)00378-8. doi: 10.1016/j.clinthera.2023.09.014. Online ahead of print.ABSTRACTPURPOSE: Pulmonary embolism (PE) is a significant contributor to mortality in patients with cancer. Although anticoagulation serves as the cornerstone of treatment for cancer-associated PE, it has not been emphasized in real-world settings. The aim of this study was to examine the impact of suboptimal anticoagulant treatment on the prognosis of cancer-associated PE.METHODS: A cohort of 356 individuals newly diagnosed with acute PE were enrolled. The primary outcome of the study was recurrent venous thromboembol...
Source: Clinical Therapeutics - October 14, 2023 Category: Drugs & Pharmacology Authors: Mingjie Liu Xianming Qiu Yuanyuan Sun Qi Li Jing Wen Guixiang Liu Zhouhong Yao Ling Zhu Source Type: research
Personalized Minimal Effective Concentration Therapy
Clin Ther. 2023 Oct 12:S0149-2918(23)00379-X. doi: 10.1016/j.clinthera.2023.09.015. Online ahead of print.ABSTRACTIt has been recognized for literally centuries that patients should be given only the amount of medication necessary to treat disease(s) or relieve symptoms. It is also well known that this amount can vary greatly between patients or even over time in the same patient. The ability to identify this amount, that is, to "personalize" dosing, requires a reliable measure of a patient's response to treatment. The development of analytical methods for the accurate measurement of pharmacologically meaningful drug conce...
Source: Clinical Therapeutics - October 14, 2023 Category: Drugs & Pharmacology Authors: Philip D Walson Source Type: research
Intensify Standardized Anticoagulation for Cancer-Associated Pulmonary Embolism: From Single-Center Real-World Data
Clin Ther. 2023 Oct 12:S0149-2918(23)00378-8. doi: 10.1016/j.clinthera.2023.09.014. Online ahead of print.ABSTRACTPURPOSE: Pulmonary embolism (PE) is a significant contributor to mortality in patients with cancer. Although anticoagulation serves as the cornerstone of treatment for cancer-associated PE, it has not been emphasized in real-world settings. The aim of this study was to examine the impact of suboptimal anticoagulant treatment on the prognosis of cancer-associated PE.METHODS: A cohort of 356 individuals newly diagnosed with acute PE were enrolled. The primary outcome of the study was recurrent venous thromboembol...
Source: Clinical Therapeutics - October 14, 2023 Category: Drugs & Pharmacology Authors: Mingjie Liu Xianming Qiu Yuanyuan Sun Qi Li Jing Wen Guixiang Liu Zhouhong Yao Ling Zhu Source Type: research
Deprescribing in Older Adults: Implementing Effective Practices
Clin Ther. 2023 Oct 7:S0149-2918(23)00358-2. doi: 10.1016/j.clinthera.2023.09.013. Online ahead of print.NO ABSTRACTPMID:37813774 | DOI:10.1016/j.clinthera.2023.09.013 (Source: Clinical Therapeutics)
Source: Clinical Therapeutics - October 9, 2023 Category: Drugs & Pharmacology Authors: William W Hung Source Type: research
Multidisciplinary Care of Alcohol-Related Liver Disease and Alcohol Use Disorder: A Narrative Review for Hepatology and Addiction Clinicians
Clin Ther. 2023 Oct 7:S0149-2918(23)00381-8. doi: 10.1016/j.clinthera.2023.09.016. Online ahead of print.ABSTRACTPURPOSE: Models of integrated, multidisciplinary care are optimal in the setting of complex, chronic diseases and in the overlap of medical and mental health disease, both of which apply to alcohol-related liver disease (ALD). Alcohol use disorder (AUD) drives nearly all cases of ALD, and coexisting mental health disease is common. ALD is a complex condition with severe clinical manifestations and high mortality that can occasionally lead to liver transplantation. As a result, integrated care for ALD is an attra...
Source: Clinical Therapeutics - October 9, 2023 Category: Drugs & Pharmacology Authors: Hersh Shroff Heather Gallagher Source Type: research
Enhancing Risk Stratification on Coronary Computed Tomography Angiography: The Role of Artificial Intelligence
Clin Ther. 2023 Oct 7:S0149-2918(23)00385-5. doi: 10.1016/j.clinthera.2023.09.019. Online ahead of print.ABSTRACTPURPOSE: To describe and outline the role of artificial intelligence (AI) in assisting coronary computed tomography angiography (CCTA) in enhancing risk stratification.METHODS: A comprehensive review of the literature was performed to identify published work investigating the utility of applying AI to CCTA.FINDINGS: CCTA is an excellent diagnostic tool for the detection of atherosclerotic cardiovascular disease. The noninvasive nature and high diagnostic accuracy have made CCTA a viable alternative to invasive c...
Source: Clinical Therapeutics - October 9, 2023 Category: Drugs & Pharmacology Authors: Biyanka Jaltotage Sara Sukudom Abdul Rahman Ihdayhid Girish Dwivedi Source Type: research
Deprescribing in Older Adults: Implementing Effective Practices
Clin Ther. 2023 Oct 7:S0149-2918(23)00358-2. doi: 10.1016/j.clinthera.2023.09.013. Online ahead of print.NO ABSTRACTPMID:37813774 | DOI:10.1016/j.clinthera.2023.09.013 (Source: Clinical Therapeutics)
Source: Clinical Therapeutics - October 9, 2023 Category: Drugs & Pharmacology Authors: William W Hung Source Type: research
Multidisciplinary Care of Alcohol-Related Liver Disease and Alcohol Use Disorder: A Narrative Review for Hepatology and Addiction Clinicians
Clin Ther. 2023 Oct 7:S0149-2918(23)00381-8. doi: 10.1016/j.clinthera.2023.09.016. Online ahead of print.ABSTRACTPURPOSE: Models of integrated, multidisciplinary care are optimal in the setting of complex, chronic diseases and in the overlap of medical and mental health disease, both of which apply to alcohol-related liver disease (ALD). Alcohol use disorder (AUD) drives nearly all cases of ALD, and coexisting mental health disease is common. ALD is a complex condition with severe clinical manifestations and high mortality that can occasionally lead to liver transplantation. As a result, integrated care for ALD is an attra...
Source: Clinical Therapeutics - October 9, 2023 Category: Drugs & Pharmacology Authors: Hersh Shroff Heather Gallagher Source Type: research
Enhancing Risk Stratification on Coronary Computed Tomography Angiography: The Role of Artificial Intelligence
Clin Ther. 2023 Oct 7:S0149-2918(23)00385-5. doi: 10.1016/j.clinthera.2023.09.019. Online ahead of print.ABSTRACTPURPOSE: To describe and outline the role of artificial intelligence (AI) in assisting coronary computed tomography angiography (CCTA) in enhancing risk stratification.METHODS: A comprehensive review of the literature was performed to identify published work investigating the utility of applying AI to CCTA.FINDINGS: CCTA is an excellent diagnostic tool for the detection of atherosclerotic cardiovascular disease. The noninvasive nature and high diagnostic accuracy have made CCTA a viable alternative to invasive c...
Source: Clinical Therapeutics - October 9, 2023 Category: Drugs & Pharmacology Authors: Biyanka Jaltotage Sara Sukudom Abdul Rahman Ihdayhid Girish Dwivedi Source Type: research
Deprescribing in Older Adults: Implementing Effective Practices
Clin Ther. 2023 Oct 7:S0149-2918(23)00358-2. doi: 10.1016/j.clinthera.2023.09.013. Online ahead of print.NO ABSTRACTPMID:37813774 | DOI:10.1016/j.clinthera.2023.09.013 (Source: Clinical Therapeutics)
Source: Clinical Therapeutics - October 9, 2023 Category: Drugs & Pharmacology Authors: William W Hung Source Type: research
Multidisciplinary Care of Alcohol-Related Liver Disease and Alcohol Use Disorder: A Narrative Review for Hepatology and Addiction Clinicians
Clin Ther. 2023 Oct 7:S0149-2918(23)00381-8. doi: 10.1016/j.clinthera.2023.09.016. Online ahead of print.ABSTRACTPURPOSE: Models of integrated, multidisciplinary care are optimal in the setting of complex, chronic diseases and in the overlap of medical and mental health disease, both of which apply to alcohol-related liver disease (ALD). Alcohol use disorder (AUD) drives nearly all cases of ALD, and coexisting mental health disease is common. ALD is a complex condition with severe clinical manifestations and high mortality that can occasionally lead to liver transplantation. As a result, integrated care for ALD is an attra...
Source: Clinical Therapeutics - October 9, 2023 Category: Drugs & Pharmacology Authors: Hersh Shroff Heather Gallagher Source Type: research
Enhancing Risk Stratification on Coronary Computed Tomography Angiography: The Role of Artificial Intelligence
Clin Ther. 2023 Oct 7:S0149-2918(23)00385-5. doi: 10.1016/j.clinthera.2023.09.019. Online ahead of print.ABSTRACTPURPOSE: To describe and outline the role of artificial intelligence (AI) in assisting coronary computed tomography angiography (CCTA) in enhancing risk stratification.METHODS: A comprehensive review of the literature was performed to identify published work investigating the utility of applying AI to CCTA.FINDINGS: CCTA is an excellent diagnostic tool for the detection of atherosclerotic cardiovascular disease. The noninvasive nature and high diagnostic accuracy have made CCTA a viable alternative to invasive c...
Source: Clinical Therapeutics - October 9, 2023 Category: Drugs & Pharmacology Authors: Biyanka Jaltotage Sara Sukudom Abdul Rahman Ihdayhid Girish Dwivedi Source Type: research
Deprescribing in Older Adults: Implementing Effective Practices
Clin Ther. 2023 Oct 7:S0149-2918(23)00358-2. doi: 10.1016/j.clinthera.2023.09.013. Online ahead of print.NO ABSTRACTPMID:37813774 | DOI:10.1016/j.clinthera.2023.09.013 (Source: Clinical Therapeutics)
Source: Clinical Therapeutics - October 9, 2023 Category: Drugs & Pharmacology Authors: William W Hung Source Type: research
Multidisciplinary Care of Alcohol-Related Liver Disease and Alcohol Use Disorder: A Narrative Review for Hepatology and Addiction Clinicians
Clin Ther. 2023 Oct 7:S0149-2918(23)00381-8. doi: 10.1016/j.clinthera.2023.09.016. Online ahead of print.ABSTRACTPURPOSE: Models of integrated, multidisciplinary care are optimal in the setting of complex, chronic diseases and in the overlap of medical and mental health disease, both of which apply to alcohol-related liver disease (ALD). Alcohol use disorder (AUD) drives nearly all cases of ALD, and coexisting mental health disease is common. ALD is a complex condition with severe clinical manifestations and high mortality that can occasionally lead to liver transplantation. As a result, integrated care for ALD is an attra...
Source: Clinical Therapeutics - October 9, 2023 Category: Drugs & Pharmacology Authors: Hersh Shroff Heather Gallagher Source Type: research
Enhancing Risk Stratification on Coronary Computed Tomography Angiography: The Role of Artificial Intelligence
Clin Ther. 2023 Oct 7:S0149-2918(23)00385-5. doi: 10.1016/j.clinthera.2023.09.019. Online ahead of print.ABSTRACTPURPOSE: To describe and outline the role of artificial intelligence (AI) in assisting coronary computed tomography angiography (CCTA) in enhancing risk stratification.METHODS: A comprehensive review of the literature was performed to identify published work investigating the utility of applying AI to CCTA.FINDINGS: CCTA is an excellent diagnostic tool for the detection of atherosclerotic cardiovascular disease. The noninvasive nature and high diagnostic accuracy have made CCTA a viable alternative to invasive c...
Source: Clinical Therapeutics - October 9, 2023 Category: Drugs & Pharmacology Authors: Biyanka Jaltotage Sara Sukudom Abdul Rahman Ihdayhid Girish Dwivedi Source Type: research
