Development of an Improved Adenovirus Vector and Its Application to the Treatment of Lifestyle-Related Diseases
Biol Pharm Bull. 2024;47(5):886-894. doi: 10.1248/bpb.b23-00837.ABSTRACTThe number of patients with lifestyle-related diseases such as type 2 diabetes mellitus (T2DM) and metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as non-alcoholic fatty liver disease (NAFLD), has continued to increase worldwide. Therefore, development of innovative therapeutic methods targeting lifestyle-related diseases is required. Gene therapy has attracted considerable attention as an advanced medical treatment. Safe and high-performance vectors are essential for the practical application of gene therapy. Replicati...
Source: Biological and Pharmaceutical Bulletin - May 1, 2024 Category: Drugs & Pharmacology Authors: Kahori Shimizu Source Type: research
Connecting the Dots: How Herpes Viruses Influence Type 2 Diabetes: Insights from Experimental Researches
Clin Med Insights Endocrinol Diabetes. 2024 Apr 29;17:11795514241249013. doi: 10.1177/11795514241249013. eCollection 2024.NO ABSTRACTPMID:38689700 | PMC:PMC11060029 | DOI:10.1177/11795514241249013 (Source: Herpes)
Source: Herpes - May 1, 2024 Category: Infectious Diseases Authors: Ushna Zameer Eisha Saqib Muhammad Salman Munshi Samia Rohail Source Type: research
Autonomic Dysfunction from Diagnosis to Treatment
Prim Care. 2024 Jun;51(2):359-373. doi: 10.1016/j.pop.2024.02.006. Epub 2024 Mar 20.ABSTRACTAutonomic disorders can present with hypotension, gastrointestinal, genitourinary symptoms, and heat intolerance. Diabetes is the most common causes of autonomic failure, and management should focus on glucose control to prevent developing autonomic symptoms. The most prevalent cause of dysautonomia, or autonomic dysfunction, is Postural Orthostatic Tachycardia Syndrome (POTS). Autonomic testing characterizes causes for nonspecific symptoms but is not necessary in patients with classic presentations. Treatment for autonomic dysfunct...
Source: Primary Care - May 1, 2024 Category: Primary Care Authors: Amanda C Peltier Source Type: research
Home blood pressure measurement self-reporting in real-life practices using the Hy-Result app: self-monitoring and digital pathway
CONCLUSIONS: Our real-life study shows that 90% of the HBPM reports include the required minimum number of BP readings to allow the calculation of a reliable average among whom 40% have uncontrolled BP levels. The self-management Hy-Result web app demonstrates significant potential for inclusion in the patient care process and reinforces the patient's engagement to independently monitor and self-reported their BP. When the mean BP is not within the recommended range, the users were automatically prompted by text messages to seek medical advice by the software. Further research should determine the extent to which users adh...
Source: Primary Care - May 1, 2024 Category: Primary Care Authors: Nicolas Postel-Vinay Nicole Gebara Roland Asmar Dominique Stephan Aurelien Lorthioir Laurence Amar Source Type: research
Circulating interleukin 17A and other inflammatory proteins may predict cardiovascular disease in early rheumatoid arthritis
CONCLUSION: Circulating IL-17A at RA diagnosis predicted future CVD, although we cannot exclude that this finding is due to multiple testing. The association was independent of traditional CVD risk factors, and of ESR at the time of diagnosis. Furthermore, OPG may be a predictor of CVD. We also identified some novel potential biomarkers for CVD in RA.PMID:38692670 | DOI:10.3899/jrheum.2023-1078 (Source: J Rheumatol)
Source: J Rheumatol - May 1, 2024 Category: Rheumatology Authors: Emil Rydell Lennart T H Jacobsson Carl Turesson Source Type: research
Characteristics of Human Leukocyte Antigen Class II Genes in Japanese Patients with Type 1 Diabetes and Autoimmune Thyroid Disease
Tohoku J Exp Med. 2024 May 2. doi: 10.1620/tjem.2024.J027. Online ahead of print.NO ABSTRACTPMID:38692862 | DOI:10.1620/tjem.2024.J027 (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - May 1, 2024 Category: Research Authors: Risa Kajita Haruna Takahashi Satoshi Yoshino Shunichi Matsumoto Kazuhiko Horiguchi Shuichi Okada Masanobu Yamada Eijiro Yamada Source Type: research
Elevated cardiovascular risk and acute events in hospitalized colon cancer survivors: A decade-apart study of two nationwide cohorts
CONCLUSION: Colon cancer survivors hospitalized 10 years apart in the United States showed an increased CVD risk with an increased risk of acute cardiovascular events (stroke 28%, PE 47%, arrhythmia 41%, and cardiac arrest 63%). It is vital to regularly screen colon cancer survivors with concomitant CVD risk factors to curtail long-term cardiovascular complications.PMID:38689632 | PMC:PMC11056864 | DOI:10.5306/wjco.v15.i4.548 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - May 1, 2024 Category: Cancer & Oncology Authors: Rupak Desai Avilash Mondal Vivek Patel Sandeep Singh Shaylika Chauhan Akhil Jain Source Type: research
Endothelial dysfunction in breast cancer survivors on aromatase inhibitors: changes over time
CONCLUSIONS: We hypothesize that long-term use of AI can lead to persistent endothelial dysfunction, and further investigation is necessary. In our study, patients were on AI for approximately 5-10 years. As a result, we do not have data on whether these changes, such as EndoPAT® ratio and the elasticity of small and large arterial, are reversible with discontinuation of AI. These findings set the stage for a larger study to more conclusively determine the association between AI exposure and cardiovascular outcomes. Further studies should evaluate for multivariate associations withmodifiable risk factors for CV disease.PM...
Source: Atherosclerosis - May 1, 2024 Category: Cardiology Authors: Adnan Shaaban Ashley Petersen Heather Beckwith Natalia Florea David A Potter Douglas Yee Rachel I Vogel Daniel Duprez Anne H Blaes Source Type: research
Adiposity, type 2 diabetes and atherosclerotic cardiovascular disease risk: Use and abuse of the body mass index
Atherosclerosis. 2024 Apr 14:117546. doi: 10.1016/j.atherosclerosis.2024.117546. Online ahead of print.ABSTRACTThe worldwide prevalence of individuals with an elevated body weight has increased steadily over the past five decades. Billions of research dollars have been invested to improve our understanding of the causes and consequences of having an elevated body weight. All this knowledge has, however, failed to influence populational body weight trajectories of most countries around the world. Research on the definition of "obesity" has also evolved. Body mass index (BMI), the most commonly used tool to make its diagnosi...
Source: Atherosclerosis - May 1, 2024 Category: Cardiology Authors: Benoit J Arsenault Andr é C Carpentier Paul Poirier Jean-Pierre Despr és Source Type: research
The role of IFI16 in regulating PANoptosis and implication in heart diseases
Cell Death Discov. 2024 May 1;10(1):204. doi: 10.1038/s41420-024-01978-5.ABSTRACTInterferon Gamma Inducible Protein 16 (IFI16) belongs to the HIN-200 protein family and is pivotal in immunological responses. Serving as a DNA sensor, IFI16 identifies viral and aberrant DNA, triggering immune and inflammatory responses. It is implicated in diverse cellular death mechanisms, such as pyroptosis, apoptosis, and necroptosis. Notably, these processes are integral to the emergent concept of PANoptosis, which encompasses cellular demise and inflammatory pathways. Current research implies a significant regulatory role for IFI16 in P...
Source: Atherosclerosis - May 1, 2024 Category: Cardiology Authors: Xindi Chang Bei Wang Yingli Zhao Bing Deng Ping Liu Yiru Wang Source Type: research
Coronary artery calcium score as independent risk factor of obstructive coronary artery disease
Conclusions: Coronary artery calcium score is a valuable screening tool for identifying potential obstructive coronary artery disease, not only for individuals aged forty and above, but also for younger asymptomatic patients.PMID:38691782 | DOI:10.36740/WLek202403108 (Source: Atherosclerosis)
Source: Atherosclerosis - May 1, 2024 Category: Cardiology Authors: Vitalina V Ivachevska Rostyslava R Supyk Mykhailo M Ivachevskyi Mykhailo M Hechko Antonina V Varvarynets Source Type: research
Association of sugary drinks, carbonated beverages, vegetable and fruit juices, sweetened and black coffee, and green tea with subsequent depression: A five-year cohort study
CONCLUSIONS: Total sugary drinks, carbonated beverages, vegetable and fruit juices, and sweetened coffee may increase the risk of depression, whereas black coffee may decrease it.PMID:38691982 | DOI:10.1016/j.clnu.2024.04.017 (Source: Cancer Control)
Source: Cancer Control - May 1, 2024 Category: Cancer & Oncology Authors: Zui Narita Shinsuke Hidese Rieko Kanehara Hisateru Tachimori Hiroaki Hori Yoshiharu Kim Hiroshi Kunugi Kazuhiko Arima Satoshi Mizukami Kozo Tanno Nobuyuki Takanashi Kazumasa Yamagishi Isao Muraki Nobufumi Yasuda Isao Saito Koutatsu Maruyama Taiki Yamaji M Source Type: research
Ertugliflozin for Functional Mitral Regurgitation Associated With Heart Failure: EFFORT Trial
CONCLUSIONS: Among patients with functional MR associated with HF, ertugliflozin significantly improved LV global longitudinal strain and left atrial remodeling, and reduced functional MR. Sodium-glucose cotransporter 2 inhibitors may be considered for patients with functional MR.REGISTRATION: URL: https://www.clinicaltrials.gov; Unique identifier: NCT04231331.PMID:38690659 | DOI:10.1161/CIRCULATIONAHA.124.069144 (Source: Circulation)
Source: Circulation - May 1, 2024 Category: Cardiology Authors: Duk-Hyun Kang Sung-Ji Park Sung-Hee Shin In-Chang Hwang Yeonyee Elizabeth Yoon Hyung-Kwan Kim Mijin Kim Min-Seok Kim Sung-Cheol Yun Jong-Min Song Seok-Min Kang Source Type: research
Hyperglycemia impairs EAAT2 glutamate transporter trafficking and glutamate clearance in islets of Langerhans: implications for type 2 diabetes pathogenesis
Am J Physiol Endocrinol Metab. 2024 May 1. doi: 10.1152/ajpendo.00069.2024. Online ahead of print.ABSTRACTPancreatic endocrine cells employ a sophisticated system of paracrine and autocrine signals to synchronize their activities, including glutamate which controls hormone release and β-cell viability by acting on glutamate receptors expressed by endocrine cells. We here investigate whether alteration of the Excitatory Amino Acid Transporter 2 (EAAT2), the major glutamate clearance system in the islet, may occur in type 2 diabetes mellitus (T2DM) and contribute to β-cell dysfunction. Increased EAAT2 intracellular localiz...
Source: Am J Physiol Endocri... - May 1, 2024 Category: Endocrinology Authors: Alessandra Galli Stefania Moretti Nevia Dule Eliana Sara Di Cairano Michela Castagna Paola Marciani Cristina Battaglia Federico Bertuzzi Ida Pastore Paolo Fiorina Stefano La Rosa Alberto Davalli Franco Folli Carla Perego Source Type: research
Linarin Ameliorates Restenosis After Vascular Injury in Type 2 Diabetes Mellitus via Regulating ADAM10-Mediated Notch Signaling Pathway
Cardiovasc Toxicol. 2024 May 1. doi: 10.1007/s12012-024-09863-4. Online ahead of print.ABSTRACTVascular lesions frequently arise as complication in patients diagnosed with diabetes mellitus (DM). Presently, percutaneous coronary intervention (PCI) and antithrombotic therapy serve as primary treatments. However, in-stent restenosis persists as a challenging clinical issue following PCI, lacking sustained and effective treatment. Linarin (LN) exhibits diverse pharmacological activities and is regarded as a potential drug for treating various diseases, including DM. But its specific role in restenosis after vascular injury in...
Source: Cardiovascular Toxicology - May 1, 2024 Category: Cardiology Authors: Aihua Jiang Lin Liu Jianping Wang Yinglan Liu Shanshan Deng Tao Jiang Source Type: research
