Reasons for Drinking among College Students in Japan: A Cross-Sectional Study.
Abstract Binge drinking by college students is a problematic behavior. However, data on binge drinking and the reasons for drinking by college students in Japan are scarce. We explored the reasons for drinking among college students. The study used a cross-sectional design and a self-administered questionnaire. From December 2016 to March 2017, we sampled undergraduate and graduate students aged 20 or older at 35 colleges in the Kanto region of Japan. The questionnaire addressed 1) frequency of drinking alcohol, 2) amount of drinking per day, 3) frequency of binge drinking in the past year, and 4) reasons for drin...
Source: The Tohoku Journal of Experimental Medicine - December 1, 2018 Category: Research Authors: Kawaida K, Yoshimoto H, Goto R, Saito G, Ogai Y, Morita N, Saito T, Takahashi S Tags: Tohoku J Exp Med Source Type: research

Evaluation for Fatigue and Accident Risk of Korean Commercial Bus Drivers.
Abstract Many Korean bus drivers work long hours, which causes fatigue and increased risk of accidents during driving. Their fatigue due to long working hours may cause a significant accident accompanied by injuries of the general population. The present study aimed to evaluate the fatigue and accident risk in Korean commercial bus drivers. The subjects were 16 city and express bus drivers with various work schedules: 2 shifts (2 shifts in a day), WR (duty-off), W2R (duty-duty-off), and W4R2 (duty-duty-duty-duty-off-off). We measured the subjects' heart rate in their workplace during their work and calculated rela...
Source: The Tohoku Journal of Experimental Medicine - December 1, 2018 Category: Research Authors: Kim H, Jang TW, Kim HR, Lee S Tags: Tohoku J Exp Med Source Type: research

The Physiological Variation in Plasma Presepsin Levels During the Early Neonatal Period.
The objective of this study is to investigate the physiological variation in plasma presepsin levels during the early neonatal period. This prospective study included 30 full-term healthy neonates, including 15 neonates delivered by cesarean section. Plasma presepsin levels were examined at birth and on the first day and the fifth day of life in neonates, and the levels on the 5th day of life were lower than those at any other points (P
Source: The Tohoku Journal of Experimental Medicine - December 1, 2018 Category: Research Authors: Ishii M, Hoshina T, Ichikawa S, Shimizu D, Araki S, Kinjo T, Shibata E, Hachisuga T, Kusuhara K Tags: Tohoku J Exp Med Source Type: research

Determinants Strengthening Japanese Nurses' Intention to Stay at Their Current Hospital.
Abstract In order to retain nursing staff, it is crucial to have a comprehensive understanding of the factors that motivate nurses to stay at an institution. Toward this aim, we identified a variety of factors that strengthen nurses' intention to stay at their current hospital. A cross-sectional questionnaire survey was conducted at 12 hospitals in the Tohoku and Kanto regions of Japan. Of the 1,034 nurses working in those hospitals, 713 returned the questionnaire (response rate: 69.0%). Of these, we analysed the data of 485 nurses (17.42 ± 9.83 years of clinical experience, 95.3% female) (valid response ra...
Source: The Tohoku Journal of Experimental Medicine - November 27, 2018 Category: Research Authors: Satoh M, Watanabe I, Asakura K Tags: Tohoku J Exp Med Source Type: research

L-Type Amino Acid Transporter 1 Immunoreactivity as a Possible Diagnostic and Prognostic Marker of Thymic Carcinoma.
Abstract L-type amino acid transporter 1 (LAT1) functions to transport large neutral amino acids, such as leucine, isoleucine, valine, phenylalanine, tyrosine, tryptophan, methionine, and histidine. These amino acids are essential for cell growth and proliferation. Many studies have demonstrated LAT1 expression in various types of cancer, and its high expression level was associated with poor prognosis. However, the significance of LAT1 expression in thymic epithelial tumors is controversial. We conducted this retrospective study to investigate the LAT1 immunoreactivity in thymic epithelial tumors and its impact o...
Source: The Tohoku Journal of Experimental Medicine - November 21, 2018 Category: Research Authors: Maeda S, Nakazato Y, Hayashi K, Nishihira M, Inoue T, Araki O, Karube Y, Kobayashi S, Chida M Tags: Tohoku J Exp Med Source Type: research

Association between Pepsin in Bronchoalveolar Lavage Fluid and Prognosis of Chronic Fibrosing Interstitial Lung Disease.
Abstract Chronic fibrosing interstitial lung disease (ILD)s are characterized by chronic progressive fibrosis of lung which include idiopathic pulmonary fibrosis (IPF), nonspecific interstitial pneumonia (NSIP), and connective tissue disease-associated interstitial lung disease (CTD-ILD). IPF is an irreversible fibrotic lung disease which results in respiratory failure. Although NSIP and CTD-ILD can be improved or stable by treatment with corticosteroid or immunosuppressant, some of them progress to fibrotic lung diseases. Aspiration of gastric contents is suggested as an aggravating factor of ILDs. We measured pe...
Source: The Tohoku Journal of Experimental Medicine - November 10, 2018 Category: Research Authors: Kim Y, Lee YJ, Cho YJ, Yoon HI, Lee JH, Lee CT, Park JS Tags: Tohoku J Exp Med Source Type: research

Maternal Separation as Early-Life Stress Causes Enhanced Allergic Airway Responses by Inhibiting Respiratory Tolerance in Mice.
Abstract Epidemiologic studies indicate that exposure to psychosocial stress in early childhood is a risk factor of adult-onset asthma, but the mechanisms of this relationship are poorly understood. Therefore, we examined whether early-life stress increases susceptibility to adult-onset asthma by inhibiting the development of respiratory tolerance. Neonatal BALB/c female mice were aerosolized with ovalbumin (OVA) to induce immune tolerance prior to immune sensitization with an intraperitoneal injection of OVA and the adjuvant aluminum hydroxide. Maternal separation (MS) was applied as an early-life stressor during...
Source: The Tohoku Journal of Experimental Medicine - November 10, 2018 Category: Research Authors: Ouchi R, Kawano T, Yoshida H, Ishii M, Miyasaka T, Ohkawara Y, Takayanagi M, Takahashi T, Ohno I Tags: Tohoku J Exp Med Source Type: research

Chronological Changes in the Gastric Cancer Subsite in Akita, Japan: The Trends from the Data of a Hospital-Based Registration System.
Abstract With the decreasing global trend in the Helicobacter pylori infection rate, compositional changes in the gastric cancer subsites have occurred worldwide. However, the compositional changes in Asian countries, including Japan, remain to be clarified. The aim of this study is to investigate the latest chronological changes in the gastric cancer subsite using a hospital-based registration system in Akita prefecture in Japan. From 2007-2015, subsites of gastric cancers were coded according to the International Classification of Diseases for Oncology (ICD-03). The nine-year registration period was divided into...
Source: The Tohoku Journal of Experimental Medicine - October 31, 2018 Category: Research Authors: Koizumi S, Motoyama S, Watanabe N, Matsuhashi T, Iijima K Tags: Tohoku J Exp Med Source Type: research

Myeloid Sarcoma of the Paranasal Sinuses in a Patient with Acute Myeloid Leukemia.
We report an uncommon case of sinonasal MS associated with AML, who was successfully treated with hematopoietic stem-cell transplantation. A 39-year-old male was admitted with complaints of left nasal obstruction and proptosis. Computed tomography and magnetic resonance imaging identified a left ethmoidal mass involving the maxillary sinus, the orbit, and the skull base. Nasal endoscopic examination detected a whitish homogeneous mass occupying the left nasal cavity. Although accumulation of atypical lymphocytes was suspected based on initial pathological inspection, immunohistochemical analysis showed myeloperoxidase-posi...
Source: The Tohoku Journal of Experimental Medicine - October 31, 2018 Category: Research Authors: Suzuki J, Harazaki Y, Morita S, Kaga Y, Nomura K, Sugawara M, Katori Y Tags: Tohoku J Exp Med Source Type: research

Deregulated MicroRNAs in Cancer-Associated Fibroblasts from Front Tumor Tissues of Lung Adenocarcinoma as Potential Predictors of Tumor Promotion.
In conclusion, deregulated miRNAs in F-CAFs are potentially associated with CAF tumor-promoting properties. PMID: 30369556 [PubMed - in process] (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - October 31, 2018 Category: Research Authors: Negrete-Garcia MC, Ramírez-Rodriguez SL, Rangel-Escareño C, Muñoz-Montero S, Kelly-García J, Vázquez-Manríquez ME, Santillán P, Ramírez MM, Ramírez-Martínez G, Ramírez-Venegas A, Ortiz-Quintero B Tags: Tohoku J Exp Med Source Type: research

Infant Suffocation Incidents Related to Co-Sleeping or Breastfeeding in the Side-Lying Position in Japan.
Abstract Co-sleeping and breastfeeding in the side-lying position have recently been pointed out as risk factors for suffocation in sleeping infants; however, there is no actual report on an "incident." "Incident" is defined as a tense or sobering experience without a consequential fatal suffocation accident. It is important to understand infant suffocation incidents to prevent accidents during co-sleeping and breastfeeding in the side-lying position. We investigated factors and frequency of infant suffocation incidents associated with co-sleeping and breastfeeding in the side-lying position us...
Source: The Tohoku Journal of Experimental Medicine - October 31, 2018 Category: Research Authors: Tokutake C, Haga A, Sakaguchi K, Samejima A, Yoneyama M, Yokokawa Y, Ohira M, Ichikawa M, Kanai M Tags: Tohoku J Exp Med Source Type: research

Simplified Prediction Model for Accurate Assessment of Dental Caries Risk among Participants Aged 10-18 Years.
Abstract Dental caries assessment needs to be targeted at specific age groups, as many risk factors are related to patient age. Pre-teen and teenage patients, who are still at risk of occurrence of new carious lesions, need more individualized caries management strategies. Therefore, this study aimed to identify caries-related risk factors and develop a simplified risk prediction model for dental caries. Risk factors for caries were assessed in 171 participants aged 10-18 years, based on a questionnaire survey, previous history of caries, oral hygiene, microorganism colonization, saliva secretion, saliva buffer ca...
Source: The Tohoku Journal of Experimental Medicine - October 20, 2018 Category: Research Authors: Kim JM, Choi JS, Choi YH, Kim HE Tags: Tohoku J Exp Med Source Type: research

Decreased Expression of MicroRNA-107 in B Lymphocytes of Patients with Antibody-Mediated Renal Allograft Rejection.
In this study, we explored the role of miRNAs in the pathogenesis of ABMR. The differentially expressed miRNAs were identified by Affymetrix miRNA microarray analysis using B lymphocytes from 5 recipients and 5 volunteers. Based on quantitative RT-PCR, the expression levels of miR-107 were lower in the B lymphocytes from recipients than in those from volunteers. Computational analysis predicted that 3'-untranslated region of the autophagy-related protein 12 (ATG12) mRNA was targeted by miR-107, and we identified ATG12 as a target of miR-107 by Luciferase assay. Importantly, the expression levels of ATG12 in B lymphocytes o...
Source: The Tohoku Journal of Experimental Medicine - October 20, 2018 Category: Research Authors: Zhang ZW, Wang M, Hu JJ, Xu G, Zhang Y, Zhang N Tags: Tohoku J Exp Med Source Type: research

Strategic Methods for Recruiting Grandparents: The Tohoku Medical Megabank Birth and Three-Generation Cohort Study.
In conclusion, we are able to recruit not only pregnant women but also fathers and grandparents. PMID: 30333380 [PubMed - in process] (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - October 20, 2018 Category: Research Authors: Ishikuro M, Obara T, Osanai T, Yamanaka C, Sato Y, Mizuno S, Miyashita M, Kikuya M, Sakurai K, Hozawa A, Tomita H, Taki Y, Nagami F, Metoki H, Kuriyama S Tags: Tohoku J Exp Med Source Type: research

Sleep Disturbance and Hyperactivity Detected by Actigraphy in Rats with Allergic Rhinitis or Attention-Deficit Hyperactivity Disorder.
Abstract Actigraphy is an easy and noninvasive method used to monitor human ultradian cycles. However, to our knowledge, it has been not applied to experiments with rodents. Therefore, using actigraphy, we assessed the ultradian cycles and behavior of rats. Rats with or without allergic rhinitis wore an actigraphy device, and triaxial acceleration was recorded. The counts that represent physical activity were lower from 8:00 to 20:00 than those from 20:00 to 8:00 in control rats, suggesting that their sleep phase was from 8:00 to 20:00 and their awake phase from 20:00 to 8:00. The counts from 8:00 to 10:00 were si...
Source: The Tohoku Journal of Experimental Medicine - October 5, 2018 Category: Research Authors: Suzuki M, Nakayama M, Ando KB, Arima S, Nakamura Y, Yokota M, Murakami S Tags: Tohoku J Exp Med Source Type: research

Vaccination Status and Antibody Titers against Rubella and Measles among Japanese Female College Students Majoring in Childcare between 2015 and 2018.
In conclusion, despite that> 85% of students surveyed had received two doses of measles and rubella vaccines, a substantial number of students remain susceptible to measles and especially rubella at the time of college admission. PMID: 30282845 [PubMed - in process] (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - October 5, 2018 Category: Research Authors: Shoho Y, Kimura T, Yanagawa Y, Saito A, Inoue T, Suto C, Tsunekawa K, Araki O, Nara M, Tokue Y, Murakami M Tags: Tohoku J Exp Med Source Type: research

Abnormal Osmolality Gap Exists in Distal Symmetric Polyneuropathy.
Abstract Distal symmetric polyneuropathy, represented by chronic inflammatory demyelinating polyneuropathy, is a popular neurological condition. Some cases are known to be associated with genetic mutations or serum auto-antibodies, but the exact mechanisms in most cases are unknown. Recently, osmotic factors have been suggested to trigger some neurological disorders, such as neuromyelitis optica. The aim of the present study was to assess the possible association of osmotic factors in the pathogenesis of distal polyneuropathy. We prospectively measured the serum levels of osmolality, electrolytes, total protein, a...
Source: The Tohoku Journal of Experimental Medicine - October 2, 2018 Category: Research Authors: Akaishi T, Takahashi T, Nakashima I, Aoki M Tags: Tohoku J Exp Med Source Type: research

Inverse Relationship between Baseline Serum Albumin Levels and Risk of Mild Cognitive Impairment in Elderly: A Seven-Year Retrospective Cohort Study.
Abstract Mild cognitive impairment (MCI) is the prophase of dementia. MCI patients have a high risk of developing dementia. Relatively low serum albumin levels are associated with the development of several geriatric diseases, including stroke and poor cognitive performance. However, the potential relationship between serum albumin levels and MCI risk has not been fully elucidated. In the present study, we explored this relationship to increase our understanding of the pathogenesis of MCI, the finding of which may provide new ideas for the controlling of dementia. A total of 1,800 subjects who had normal cognitive...
Source: The Tohoku Journal of Experimental Medicine - September 27, 2018 Category: Research Authors: Wang L, Wang F, Liu J, Zhang Q, Lei P Tags: Tohoku J Exp Med Source Type: research

Unilateral Chewing as a Risk Factor for Hearing Loss: Association between Chewing Habits and Hearing Acuity.
This study aimed to assess the effects of unilateral chewing on hearing acuity, with a focus on the risk of hearing loss. Eighty-one participants (aged 51-87 years) were included in the present study. Their chewing habits were determined by visual inspection. The participants were divided into two groups: the Unilateral Chewing Group (UCG; n = 43) and the Bilateral Chewing Group (BCG; n = 38). The preferred chewing side was identified for the UCG. Hearing acuity was determined using pure tone audiometry in a noise-free chamber, conducted at frequencies of 500, 1,000, 2,000, and 4,000 Hz. Hearing loss was defined as a lower...
Source: The Tohoku Journal of Experimental Medicine - September 21, 2018 Category: Research Authors: Lee YR, Choi JS, Kim HE Tags: Tohoku J Exp Med Source Type: research

Concomitance of Polymorphisms in Glutathione Transferase Omega Genes Is Associated with Risk of Clear Cell Renal Cell Carcinoma.
In conclusion, the concomitance of GSTO polymorphisms may influence ccRCC risk. PMID: 30224590 [PubMed - in process] (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - September 20, 2018 Category: Research Authors: Radic TM, Coric VM, Pljesa-Ercegovac MS, Basta-Jovanovic GM, Radojevic-Skodric SM, Dragicevic DP, Matic MG, Bogdanovic LM, Dzamic ZM, Simic TP, Savic-Radojevic AR Tags: Tohoku J Exp Med Source Type: research

Inequality and Mother's Age as Determinants of Breastfeeding Continuation in Bangladesh.
Abstract The World Health Organization recommends continuing breastfeeding up to 2 years of age or beyond for sound growth and development of children. In Bangladesh, continuation rates for breastfeeding have recently decreased and effective measures are required to counter this downward trend. Although recent years have seen economic development and reductions in poverty, Bangladesh still has the highest rate of child marriage worldwide. Thus, we aimed to clarify the factors influencing breastfeeding continuation, especially from the perspective of inequality and mother's age in Bangladesh, using data from the Ba...
Source: The Tohoku Journal of Experimental Medicine - September 15, 2018 Category: Research Authors: Islam GMR, Igarashi I, Kawabuchi K Tags: Tohoku J Exp Med Source Type: research

The Japan Environment and Children's Study (JECS) in Fukushima Prefecture: Pregnancy Outcome after the Great East Japan Earthquake.
In this study, we used the results of individuals enrolled in JECS, who gave birth during 2011-2014 in Fukushima Prefecture, to elucidate pregnancy outcomes in Fukushima Prefecture. The study consisted of 12,804 maternal outcomes. We thus found that the prevalence rates of preterm birth
Source: The Tohoku Journal of Experimental Medicine - September 15, 2018 Category: Research Authors: Kyozuka H, Fujimori K, Hosoya M, Yasumura S, Yokoyama T, Sato A, Hashimoto K Tags: Tohoku J Exp Med Source Type: research

Demonstration of Mitochondrial Damage and Mitophagy in Cisplatin-Mediated Nephrotoxicity.
Abstract Cisplatin is a chemotherapeutic widely used in the treatment of various types of solid tumors. Acute kidney injury is the most critical dose-limiting factor in cancer patients treated with cisplatin; mitochondrial dysfunction and resultant cell damage by reactive oxygen species released from damaged mitochondria are suspected to be involved in the kidney injury. Pathological features of mitochondrial damage in relation to cisplatin-mediated nephrotoxicity, however, is not fully described. The purpose of this study was to demonstrate mitochondrial damage and clearance of damaged mitochondria by mitophagy i...
Source: The Tohoku Journal of Experimental Medicine - September 5, 2018 Category: Research Authors: Ichinomiya M, Shimada A, Ohta N, Inouchi E, Ogihara K, Naya Y, Nagane M, Morita T, Satoh M Tags: Tohoku J Exp Med Source Type: research

Sleep Disturbance Is Associated with New Onset and Continuation of Lower Back Pain: A Longitudinal Study among Survivors of the Great East Japan Earthquake.
Abstract Lower back pain (LBP) is a common health problem after natural disasters. Although some related factors have been reported, the effect of sleep disturbances on LBP is not clear. The purpose of this study was to elucidate the influence of sleep disturbances on LBP after the Great East Japan earthquake (GEJE). A panel study was conducted with the survivors of the GEJE (n = 2,295) at three and four years after the disaster using self-reported questionnaires. The changes in the presence of LBP during the two periods were assessed; LBP was characterized as either new onset or continuation of LBP. The participa...
Source: The Tohoku Journal of Experimental Medicine - September 5, 2018 Category: Research Authors: Yabe Y, Hagiwara Y, Sekiguchi T, Sugawara Y, Tsuchiya M, Koide M, Itaya N, Yoshida S, Sogi Y, Yano T, Tsuji I, Itoi E Tags: Tohoku J Exp Med Source Type: research

The Use of All-You-Can-Drink System, Nomihodai, Is Associated with the Increased Alcohol Consumption among College Students: A Cross-Sectional Study in Japan.
Abstract Excessive drinking by college students is a major public health problem in Japan. However, data on heavy episodic drinking (HED) and nomihodai, a several-hour all-you-can-drink system, are scarce. We surveyed the drinking behavior of undergraduate and graduate students at 35 colleges, and examined the association between HED and use of nomihodai. The study used a cross-sectional design conducted by a self-administered questionnaire. From December 2016 to March 2017, we sampled undergraduate and graduate students aged 20 or older at 35 colleges in the Kanto area, including Tokyo. The following items were m...
Source: The Tohoku Journal of Experimental Medicine - September 1, 2018 Category: Research Authors: Kawaida K, Yoshimoto H, Goto R, Saito G, Ogai Y, Morita N, Saito T Tags: Tohoku J Exp Med Source Type: research

Treatment with Lactobacillus Retards the Tumor Growth of Head and Neck Squamous Cell Carcinoma Cells Inoculated in Mice.
Abstract Bacteria have been used for more than a century to treat solid tumors. Because solid tumors generate an anaerobic environment, we evaluated the anti-tumor effect of the obligate anaerobe strain KK378, derived from Lactobacillus casei (L. casei), using mice bearing head and neck cancer. Wild-type L. casei is a nonpathogenic bacterium that is commonly used in foods. Moreover, patients with head and neck squamous cell carcinoma often have multiple cancers and cervical lymph node metastasis that can be directly sensed beneath the skin. To establish the animal model bearing head and neck cancer, we inoculated ...
Source: The Tohoku Journal of Experimental Medicine - September 1, 2018 Category: Research Authors: Miyaguchi J, Shiga K, Ogawa K, Suzuki F, Katagiri K, Saito D, Ikeda A, Horii A, Watanabe M, Igimi S Tags: Tohoku J Exp Med Source Type: research

Identification of Topics Explained by Home Doctors to Family Caregivers with Cancer Patients Died at Home: A Quantitative Text Analysis of Actual Speech in All Visits.
In conclusion, doctors should explain to family caregivers the topics of patients' death process and specific measures or procedures for reduction in care burden. PMID: 30135327 [PubMed - in process] (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - August 25, 2018 Category: Research Authors: Chiba H, Ogata T, Ito M, Kaneko S Tags: Tohoku J Exp Med Source Type: research

Age-Related Declines in Executive Function and Cerebral Oxygenation Hemodynamics.
Abstract Cerebral hemodynamics plays an important role in cognitive performance, and as such, age-related cognitive dysfunction and cerebral hypoperfusion increase the risk of dementia. However, age-related changes in cerebral oxygenation and cognitive function remain unclear. The aim of this study was to investigate age-related declines in cerebral oxygenation and executive function cross-sectionally. Ninety-eight healthy Japanese adults (age range: 23-79 years; 40 males, 58 females) participated in the present study using local advertisements. The participants were divided into 4 age groups: young (20-39 years; ...
Source: The Tohoku Journal of Experimental Medicine - August 15, 2018 Category: Research Authors: Hamasaki A, Akazawa N, Yoshikawa T, Myoenzono K, Tagawa K, Maeda S Tags: Tohoku J Exp Med Source Type: research

Serum Osteocalcin Levels in Girls with Central Precocious Puberty: Relation to the Onset of Puberty.
Abstract Osteocalcin is the non-collagenous protein produced by osteoblasts in bone. When it is released into systemic circulation in its uncarboxylated form, it regulates fat and glucose metabolism. Recent studies have shown that osteocalcin is also involved in male fertility. Because the onset of puberty is determined by ethnic, genetic, environmental, and metabolic factors, we focused on determining the role of osteocalcin in the onset of puberty. Central precocious puberty (CPP) is defined as the activation of the hypothalamic-pituitary-gonadal axis before the age of 8 in girls and 9 in boys. CPP is diagnosed ...
Source: The Tohoku Journal of Experimental Medicine - August 11, 2018 Category: Research Authors: Lee WY, Jung G, Kim HR, Nam HK, Rhie YJ, Lee KH Tags: Tohoku J Exp Med Source Type: research

Agent-Based Modeling and Simulation of Nosocomial Infection among Healthcare Workers during Ebola Virus Disease Outbreak in Sierra Leone.
Abstract Healthcare workers (HCWs) are often exposed to nosocomial infection when caring for patients with Ebola Virus Disease (EVD). During the 2014-2016 EVD outbreak in West Africa, more than 200 HCWs died of EVD in Sierra Leone. To determine the factors that are important for preventing infection among HCWs during EVD outbreak, we used agent-based modeling and simulation (ABMS) by focusing on education, training and performance of HCWs. Here, we assumed 1, 000 HCWs as "agents" to analyze their behavior within a given condition and selected four parameters (P1-P4) that are important in the prevention o...
Source: The Tohoku Journal of Experimental Medicine - August 8, 2018 Category: Research Authors: Jones-Konneh TEC, Suda T, Sasaki H, Egawa S Tags: Tohoku J Exp Med Source Type: research

Positive Emotion and its Changes during Pregnancy: Adjunct Study of Japan Environment and Children's Study in Miyagi Prefecture.
This study explored the extent of positive emotion which pregnant women aware of their own pregnancy life subjectively and variables related to the changes thereof. This was an adjunct study of the Japan Environment and Children's Study which is a nationwide epidemiological study to identify the impact of environmental factors on health and development of children in Miyagi Prefecture. Data were collected at 12 weeks (T1) and 24-28 weeks (T2) of gestation. Participants were 3,513 pregnant women. Women's degree of positive emotion was assessed through a numeric rating scale. We also measured related variables, including obs...
Source: The Tohoku Journal of Experimental Medicine - August 1, 2018 Category: Research Authors: Nakamura Y, Sato M, Watanabe I Tags: Tohoku J Exp Med Source Type: research

Underexpression of Receptor for Activated C Kinase 1 (RACK1) in Leukocytes from Patients with Severe Acute Pancreatitis.
Abstract Receptor for activated C kinase 1 (RACK1) plays an important role in regulating the immune response and cytokine expression. However, little is known about its role in acute pancreatitis (AP). We therefore investigated the role of RACK1 in AP and explored its relationship with interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α), both of which are related to AP severity. Two rat models of chemically induced AP with different severities were used: acute edematous pancreatitis (AEP) and acute necrotizing pancreatitis (ANP). The expression levels of IL-6 and TNF-α mRNAs and proteins wer...
Source: The Tohoku Journal of Experimental Medicine - July 27, 2018 Category: Research Authors: Zhang X, Guo J, Wang H, Zhang C, Shi N, Cai W, Jin T, Lin Z, Ma Y, Yang X, Xia Q, Xue P Tags: Tohoku J Exp Med Source Type: research

Fever Responses Are Enhanced with Advancing Age during Respiratory Syncytial Virus Infection among Children under 24 Months Old.
Abstract The most important risk factor for severe respiratory syncytial virus (RSV) infection is considered young age due to the immature immune system. The risk at young age is reported greater for RSV than for other respiratory infectious agents. Based on the strong association between young age and severity of RSV infection due to immature immunity, we aimed to assess whether there were any age-related differences in fever responses, as one clinical aspect of the immune response. In our observational study over two seasons (2014-2015 and 2015-2016), daily body temperatures of children under 3 years old with RS...
Source: The Tohoku Journal of Experimental Medicine - July 27, 2018 Category: Research Authors: Kawakami C, Sato A, Sumita H, Isozaki A, Shimizu H, Kanetaka T, Maehara K, Ao K, Nariai A, Takeshita F, Kizu R, Mori M Tags: Tohoku J Exp Med Source Type: research

Sera from Septic Patients Contain the Inhibiting Activity of the Extracellular ATP-Dependent Inflammasome Pathway.
Abstract Immunoparalysis is a common cause of death for critical care patients with sepsis, during which comprehensive suppression of innate and adaptive immunity plays a significant pathophysiological role. Although the underlying mechanisms are unknown, damage-associated molecular patterns (DAMPs) from septic tissues might be involved. Therefore, we surveyed sera from septic patients for factors that suppress the innate immune response to DAMPs, including adenosine triphosphate (ATP), monosodium urate, and high mobility group box-1. Macrophages, derived from THP-1 human acute monocytic leukemia cells, were incub...
Source: The Tohoku Journal of Experimental Medicine - July 25, 2018 Category: Research Authors: Ho VM, Hirohashi N, Kong WS, Yun G, Ota K, Itai J, Yamaga S, Suzuki K, Tanigawa K, Kanno M, Shime N Tags: Tohoku J Exp Med Source Type: research

Analgesic Effect of Double-Level Retrolaminar Paravertebral Block for Breast Cancer Surgery in the Early Postoperative Period: A Placebo-Controlled, Randomized Clinical Trial.
In conclusion, the double-level RLB could delay the time to initial administration of analgesics, but this technique may be insufficient to reduce the analgesic requirement within the 12-hour postoperative period following breast cancer surgery. PMID: 30012909 [PubMed - in process] (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - July 19, 2018 Category: Research Authors: Onishi E, Murakami M, Nishino R, Ohba R, Yamauchi M Tags: Tohoku J Exp Med Source Type: research

Newly Identified t(2;17)(p15;q24.2) Chromosomal Translocation Is Associated with Dysgenetic Gonads and Multiple Somatic Anomalies.
We report a 6-year-old phenotypically female referred to our department because of precocious puberty. The patient was born with Tetralogy of Fallot (TOF) and PRS. Skeletal X-ray examination showed only 11 pairs of ribs and bilateral bowed radiuses. Endocrine evaluations showed that increased levels of serum testosterone, and chromosomal analysis revealed a 46, XY, t(2;17)(p15;q24.2) karyotype. The patient was diagnosed with peripheral precocious puberty caused by over-secretion of testosterone by gonadoblastoma originating from dysgenetic gonads with Y-chromosome-related DSD. Multiple somatic abnormalities and DSD indicat...
Source: The Tohoku Journal of Experimental Medicine - July 19, 2018 Category: Research Authors: Morozumi K, Ainoya K, Takemoto J, Sakai K Tags: Tohoku J Exp Med Source Type: research

Incidence Rate, Subtype Frequency, and Occurrence Site of Malignant Lymphoma in the Gastrointestinal Tract: Population-Based Analysis in Miyagi, Japan.
Abstract Primary gastrointestinal lymphoma (PGIL) has been reported in many studies of lymphomas of the gastrointestinal tract worldwide. However, there have been few accurate population-based reports on lymphomas, and it is difficult to apply the strict definition of PGIL to all lymphomas occurring in the gastrointestinal tract. Accordingly, instead of using PGIL, this study included newly diagnosed lymphomas with biopsy or excision specimens obtained from the gastrointestinal tract (GI-related lymphomas) and aimed at presenting the incidence rate, subtype frequency, and occurrence site of GI-related lymphomas. A...
Source: The Tohoku Journal of Experimental Medicine - July 13, 2018 Category: Research Authors: Fujishima F, Katsushima H, Fukuhara N, Konosu-Fukaya S, Nakamura Y, Sasano H, Ichinohasama R Tags: Tohoku J Exp Med Source Type: research

Job Stress Factors Affect Workplace Resignation and Burnout among Japanese Rural Physicians.
Abstract Shortage of healthcare workers is a global problem. It is important to clarify factors, including job stress, that influence workplace resignation and factors that cause burnout among rural physicians. The study was designed as a cross-sectional questionnaire survey. We sent questionnaires to town or village hospitals and clinics (n = 1,898) in Hokkaido, Tohoku, Shikoku, and Kyushu and Okinawa. The number of participants was 509. Of these 7.7% were female and 21.6% were
Source: The Tohoku Journal of Experimental Medicine - July 13, 2018 Category: Research Authors: Saijo Y, Yoshioka E, Hanley SJB, Kitaoka K, Yoshida T Tags: Tohoku J Exp Med Source Type: research

Inter-Regional Differences in Travel Time to the Nearest Nursery for Children with Mild Acute Illness in Japan.
Abstract Access to day-care services for children with mild acute illness is important for working parents, because infants and toddlers often suddenly become ill, and most Japanese nursery schools do not accept children with even mild illnesses. Actual travel time to nurseries providing such day-care services is one of the indicators for measuring accessibility. However, this variable has not been well analyzed in previous work. To clarify practical access to such nurseries, this study used a car navigation algorithm to calculate the percentage of the population of children in Japan who can access nurseries provi...
Source: The Tohoku Journal of Experimental Medicine - July 10, 2018 Category: Research Authors: Ehara A Tags: Tohoku J Exp Med Source Type: research

Infliximab-Induced Tubulointerstitial Nephritis with Image Findings of Striated Nephrogram in Crohn's Disease.
Abstract Tubulointerstitial nephritis is primary injury to renal tubules and interstititum which could be resulting in decreased renal function. The acute and chronic forms are most often due to allergic drug reactions or to infections. Tubulointerstitial nephritis in Crohn's disease has rarely been reported. Imaging findings of a striated nephrogram on enhanced computed tomography (CT) could represent the clinical state of tubulointerstitial nephritis. This is the first report of tubulointerstitial nephritis caused by infliximab, monoclonal antibody against human tumor necrosis factor-α, showing striated ne...
Source: The Tohoku Journal of Experimental Medicine - July 6, 2018 Category: Research Authors: Sato T, Kawasaki Y, Ito A, Izumi H, Kawamorita N, Yamashita S, Mitsuzuka K, Matsuura T, Watanabe M, Arai Y Tags: Tohoku J Exp Med Source Type: research

Hypothiocyanous Acid Suppresses PolyI:C-Induced Antiviral Responses by Modulating IRF3 Phosphorylation in Human Airway Epithelial Cells.
In this study, we aimed to clarify the role of HOSCN in host antiviral responses against RNA viruses in airway epithelial cells using polyinosinic-polycytidylic acid (polyI:C), a mimic of viral RNA. Our results show that HOSCN repressed antiviral responses in NCI-H292 human airway epithelial cells. HOSCN decreased polyI:C-induced apoptosis and the expression levels of IFNB1, IFNL1, IFNL2 and IFNL3 mRNAs. In addition, the induction of other interferon regulatory factor 3 (IRF3)-dependent genes was also suppressed by HOSCN. Further analyses focused on IRF3 revealed that HOSCN inhibited the phosphorylation of IRF3 at Ser386 a...
Source: The Tohoku Journal of Experimental Medicine - July 3, 2018 Category: Research Authors: Nguyen TT, Suzuki S, Sugamata R, Ito F, Tran DH, Yamamoto T, Kawachi S, Suzuki K Tags: Tohoku J Exp Med Source Type: research

Expression of TBC1D16 Is Associated with Favorable Prognosis of Epithelial Ovarian Cancer.
Abstract Epithelial ovarian cancer (EOC) is the most lethal gynecologic malignancy with high recurrence and poor prognosis duo to the lack of effective biomarkers. TBC1 domain family member 16 (TBC1D16), a GTPase-activating protein, is involved in regulating intracellular trafficking in tumorigenesis and metastasis. However, the clinical significance of TBC1D16 in EOC remains unknown. In the present study, we investigated the expression and prognostic significance of TBC1D16 in EOC and its relationship with the expression of vascular endothelial growth factor (VEGF). The tissue specimens included 156 histologicall...
Source: The Tohoku Journal of Experimental Medicine - July 3, 2018 Category: Research Authors: Yang Z, Shen H, He W, Ouyang L, Guo Y, Qian F, Xu B, Xie D, Yang G Tags: Tohoku J Exp Med Source Type: research

Efficacy and Safety of Trastuzumab in Combination with S-1 and Cisplatin Therapy for Japanese Patients with HER2-Positive Advanced Gastric Cancer: Retrospective Analysis.
Abstract The combinations of oral fluoropyrimidines and cisplatin such as capecitabine and cisplatin (XP) or S-1 and cisplatin (SP) are regarded as a standard therapy against unresectable, recurrent, or advanced gastric cancer (AGC). Especially, SP is the most common regimen against AGC in Japan. For patients with human epidermal growth factor receptor type 2 (HER2)-positive AGC, trastuzumab, a monoclonal antibody targeting HER2 antibody, is additionally used in combination. Although trastuzumab in combination with XP (trastuzumab-XP) have been widely accepted, the efficacy of trastuzumab in combination with SP (t...
Source: The Tohoku Journal of Experimental Medicine - June 27, 2018 Category: Research Authors: Okita A, Imai H, Takahashi M, Takahashi H, Umegaki S, Kawamura Y, Hiraide S, Ouchi K, Sato Y, Okada Y, Komine K, Saijo K, Takahashi S, Takahashi M, Shirota H, Ohori H, Gamoh M, Ishioka C Tags: Tohoku J Exp Med Source Type: research

PINK1 Expression Is Associated with Poor Prognosis in Lung Adenocarcinoma.
In conclusion, high PINK1 expression is correlated with poor response to chemotherapy and is an independent prognostic factor for AC, but not for SCC. Our findings suggest that PINK1 detection could help stratify patients who may have poor response to chemotherapy and guide the individual treatment. PMID: 29937472 [PubMed - in process] (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - June 27, 2018 Category: Research Authors: Chang G, Zhang W, Ma Y, Wen Q Tags: Tohoku J Exp Med Source Type: research

Improvement in Patient-Reported Outcomes and Forced Vital Capacity during Nintedanib Treatment of Idiopathic Pulmonary Fibrosis.
Abstract Idiopathic pulmonary fibrosis (IPF) is a progressive and incurable disease with limited overall survival. Nintedanib is a multikinase inhibitor, and its efficacy on IPF was demonstrated in phase III trials. However, a discrepancy exists between forced vital capacity (FVC) and patient-reported outcomes during nintedanib treatment. Accordingly, we retrospectively analyzed the effects of nintedanib on FVC and patient-reported outcomes among 25 IPF patients. Patient-reported outcomes were evaluated with modified medical research council (mMRC) grade and COPD assessment test (CAT) score. The changes in mMRC gr...
Source: The Tohoku Journal of Experimental Medicine - June 23, 2018 Category: Research Authors: Takeda T, Takeuchi M, Saitoh M, Takeda S Tags: Tohoku J Exp Med Source Type: research

A Novel SDHB IVS2-2A > C Mutation Is Responsible for Hereditary Pheochromocytoma/Paraganglioma Syndrome.
In this study, we investigated mutations of SDH genes in six HPPS patients from four Japanese pedigrees using peripheral blood lymphocytes (from one patient with pheochromocytoma and five patients with neck paraganglioma) and tumor tissues (from two patients with paraganglioma). Results showed that all of these pedigrees harbor germline mutations in one of the SDH genes. In two pedigrees, a novel IVS2-2A>C mutation in SDHB, at the acceptor-site in intron 2, was found, and the tumor RNA of the patient clearly showed frameshift caused by exon skipping. Each of the remaining two pedigrees harbors a reported missense mutati...
Source: The Tohoku Journal of Experimental Medicine - June 23, 2018 Category: Research Authors: Yamanaka M, Shiga K, Fujiwara S, Mizuguchi Y, Yasuda S, Ishizawa K, Saiki Y, Higashi K, Ogawa T, Kimura N, Horii A Tags: Tohoku J Exp Med Source Type: research

Microarray Expression Profiling of microRNAs Reveals Potential Biomarkers for Hepatocellular Carcinoma.
Abstract Hepatocellular carcinoma (HCC) remains a major health problem for delayed diagnosis, inefficient surveillance and poor prognosis. Recent studies have indicated that non-coding RNAs contribute to the development of new strategies for diagnosis and treatment of HCC. In the present study, we employed 18 pairs of HCC and matched non-tumor tissues for the identification of differentially expressed microRNAs (miRNAs) in HCC, among which 7 paired specimens were selected randomly for microarray detection. Totally, twenty-three miRNAs were screened out to have statistically significant differences with the threshold of P
Source: The Tohoku Journal of Experimental Medicine - June 16, 2018 Category: Research Authors: Zhu HR, Huang RZ, Yu XN, Shi X, Bilegsaikhan E, Guo HY, Song GQ, Weng SQ, Dong L, Janssen HLA, Shen XZ, Zhu JM Tags: Tohoku J Exp Med Source Type: research

Decreased Respiratory Muscle Function Is Associated with Impaired Trunk Balance among Chronic Stroke Patients: A Cross-sectional Study.
Abstract The abdominal muscles play a role in trunk balance. Abdominal muscle thickness is asymmetrical in stroke survivors, who also have decreased respiratory muscle function. We compared the thickness of the abdominal muscles between the affected and less affected sides in stroke survivors. In addition, the relationship between respiratory muscle function and trunk balance was evaluated. Chronic stroke patients (18 men, 15 women; mean age, 58.94 ± 12.30 years; Mini-Mental Status Examination score ≥ 24) who could sit without assist were enrolled. Abdominal muscle thickness during rest and contraction w...
Source: The Tohoku Journal of Experimental Medicine - June 2, 2018 Category: Research Authors: Lee K, Cho JE, Hwang DY, Lee W Tags: Tohoku J Exp Med Source Type: research

Onset of Hemophagocytic Lymphohistiocytosis during Piperacillin-Tazobactam Therapy in Three Children with Acute Focal Bacterial Nephritis.
In conclusion, prolonged antibiotic therapy with PIPC-TAZ could be a cause of HLH. PMID: 29798969 [PubMed - in process] (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - May 30, 2018 Category: Research Authors: Miyabayashi H, Kumaki S, Sato A, Onuma R, Noguchi R, Sato T, Metoki T, Watanabe Y, Tazawa Y, Imaizumi M, Kitaoka S Tags: Tohoku J Exp Med Source Type: research

Serum Levels of TRIM72 Are Lower among Patients with Colon Cancer: Identification of a Potential Diagnostic Marker.
In conclusion, serum TRIM72 may be a potential biomarker for the diagnosis and the prognosis of colon cancer. PMID: 29806630 [PubMed - in process] (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - May 30, 2018 Category: Research Authors: Chen Z, Yin X, Li K, Chen S, Li H, Li Y, Zhang Q, Wang H, Qiu Y Tags: Tohoku J Exp Med Source Type: research