Monoacylglycerol Lipase (MAGL) Inhibition Impedes the Osteosarcoma Progression by Regulating Epithelial Mesenchymal Transition
This study aimed to evaluate the efficacy and underlying mechanism of monoacylglycerol lipase (MAGL) on osteosarcoma progression. MAGL expression was downregulated by shMAGL or JZL184 (an MAGL inhibitor) and upregulated through plasmid. RT-PCR and Western blot were utilized to determine the expression of target molecules. CCK-8 assay, transwell assay and ROS assay were performed to investigate the inhibitory effect of MAGL on the growth and metastasis of osteosarcoma cells. The role of JZL184 on tumor growth was examined in cisplatin-resistant MG-63 (MG-63/R) xenograft model. MAGL was highly expressed in osteosarcoma cells...
Source: The Tohoku Journal of Experimental Medicine - January 24, 2022 Category: Research Authors: Xiaokang Gong Xin Zheng Yang Huang Weihai Song Gang Chen Tao Chen Source Type: research

Mining the Biomarkers and Associated-Drugs for Esophageal Squamous Cell Carcinoma by Bioinformatic Methods
This study aimed to screen potential biomarkers and drugs in ESCC. Firstly, GSE26886, GSE111044 and GSE77861 were downloaded from the Gene Expression Omnibus (GEO) database. Next, the differentially expressed genes (DEGs) between cancer and noncancerous tissues were analyzed by the GEO2R. The Gene Ontology (GO) annotation, the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway annotation, the protein-protein interaction (PPI) analysis and hub genes screened were conducted by some bioinformatic methods, respectively. Lastly, the hub genes and potential drugs were verified by the GEPIA2 and the QuartataWeb database. The ...
Source: The Tohoku Journal of Experimental Medicine - January 24, 2022 Category: Research Authors: Xiuying Kuang Zhihui Liu Source Type: research

Circadian Clock Gene Polymorphisms and Sleep-Onset Problems in a Population-Based Cohort Study: The Yamagata Study
This study included 1,397 subjects aged ≥ 40 years who participated in an annual health check-up in Yamagata Prefecture. A total of 80 SNPs of 5 circadian clock genes were analyzed. Multivariate logistic regression analyses identified variant rs11113179 in CRY1 and variants rs1026071 and rs1562438 in BMAL1 as genetic risk factors for sleep induction disorder. These findings suggest that CRY1 and BMAL1 polymorphisms are related to sleep-onset problems in a Japanese general population. However, none of the SNPs remained significant at a stringent level of multiple correction.PMID:34924458 | DOI:10.1620/tjem.255.325 (Sourc...
Source: The Tohoku Journal of Experimental Medicine - December 20, 2021 Category: Research Authors: Kaori Sakurada Tsuneo Konta Sanae Takahashi Narumi Murakami Hidenori Sato Ryoko Murakami Masafumi Watanabe Kenichi Ishizawa Yoshiyuki Ueno Hidetoshi Yamashita Takamasa Kayama Source Type: research

Circadian Clock Gene Polymorphisms and Sleep-Onset Problems in a Population-Based Cohort Study: The Yamagata Study
This study included 1,397 subjects aged ≥ 40 years who participated in an annual health check-up in Yamagata Prefecture. A total of 80 SNPs of 5 circadian clock genes were analyzed. Multivariate logistic regression analyses identified variant rs11113179 in CRY1 and variants rs1026071 and rs1562438 in BMAL1 as genetic risk factors for sleep induction disorder. These findings suggest that CRY1 and BMAL1 polymorphisms are related to sleep-onset problems in a Japanese general population. However, none of the SNPs remained significant at a stringent level of multiple correction.PMID:34924458 | DOI:10.1620/tjem.255.325 (Sourc...
Source: The Tohoku Journal of Experimental Medicine - December 20, 2021 Category: Research Authors: Kaori Sakurada Tsuneo Konta Sanae Takahashi Narumi Murakami Hidenori Sato Ryoko Murakami Masafumi Watanabe Kenichi Ishizawa Yoshiyuki Ueno Hidetoshi Yamashita Takamasa Kayama Source Type: research

Circadian Clock Gene Polymorphisms and Sleep-Onset Problems in a Population-Based Cohort Study: The Yamagata Study
This study included 1,397 subjects aged ≥ 40 years who participated in an annual health check-up in Yamagata Prefecture. A total of 80 SNPs of 5 circadian clock genes were analyzed. Multivariate logistic regression analyses identified variant rs11113179 in CRY1 and variants rs1026071 and rs1562438 in BMAL1 as genetic risk factors for sleep induction disorder. These findings suggest that CRY1 and BMAL1 polymorphisms are related to sleep-onset problems in a Japanese general population. However, none of the SNPs remained significant at a stringent level of multiple correction.PMID:34924458 | DOI:10.1620/tjem.255.325 (Sourc...
Source: The Tohoku Journal of Experimental Medicine - December 20, 2021 Category: Research Authors: Kaori Sakurada Tsuneo Konta Sanae Takahashi Narumi Murakami Hidenori Sato Ryoko Murakami Masafumi Watanabe Kenichi Ishizawa Yoshiyuki Ueno Hidetoshi Yamashita Takamasa Kayama Source Type: research

Circadian Clock Gene Polymorphisms and Sleep-Onset Problems in a Population-Based Cohort Study: The Yamagata Study
This study included 1,397 subjects aged ≥ 40 years who participated in an annual health check-up in Yamagata Prefecture. A total of 80 SNPs of 5 circadian clock genes were analyzed. Multivariate logistic regression analyses identified variant rs11113179 in CRY1 and variants rs1026071 and rs1562438 in BMAL1 as genetic risk factors for sleep induction disorder. These findings suggest that CRY1 and BMAL1 polymorphisms are related to sleep-onset problems in a Japanese general population. However, none of the SNPs remained significant at a stringent level of multiple correction.PMID:34924458 | DOI:10.1620/tjem.255.325 (Sourc...
Source: The Tohoku Journal of Experimental Medicine - December 20, 2021 Category: Research Authors: Kaori Sakurada Tsuneo Konta Sanae Takahashi Narumi Murakami Hidenori Sato Ryoko Murakami Masafumi Watanabe Kenichi Ishizawa Yoshiyuki Ueno Hidetoshi Yamashita Takamasa Kayama Source Type: research

Circadian Clock Gene Polymorphisms and Sleep-Onset Problems in a Population-Based Cohort Study: The Yamagata Study
This study included 1,397 subjects aged ≥ 40 years who participated in an annual health check-up in Yamagata Prefecture. A total of 80 SNPs of 5 circadian clock genes were analyzed. Multivariate logistic regression analyses identified variant rs11113179 in CRY1 and variants rs1026071 and rs1562438 in BMAL1 as genetic risk factors for sleep induction disorder. These findings suggest that CRY1 and BMAL1 polymorphisms are related to sleep-onset problems in a Japanese general population. However, none of the SNPs remained significant at a stringent level of multiple correction.PMID:34924458 | DOI:10.1620/tjem.255.325 (Sourc...
Source: The Tohoku Journal of Experimental Medicine - December 20, 2021 Category: Research Authors: Kaori Sakurada Tsuneo Konta Sanae Takahashi Narumi Murakami Hidenori Sato Ryoko Murakami Masafumi Watanabe Kenichi Ishizawa Yoshiyuki Ueno Hidetoshi Yamashita Takamasa Kayama Source Type: research

Circadian Clock Gene Polymorphisms and Sleep-Onset Problems in a Population-Based Cohort Study: The Yamagata Study
This study included 1,397 subjects aged ≥ 40 years who participated in an annual health check-up in Yamagata Prefecture. A total of 80 SNPs of 5 circadian clock genes were analyzed. Multivariate logistic regression analyses identified variant rs11113179 in CRY1 and variants rs1026071 and rs1562438 in BMAL1 as genetic risk factors for sleep induction disorder. These findings suggest that CRY1 and BMAL1 polymorphisms are related to sleep-onset problems in a Japanese general population. However, none of the SNPs remained significant at a stringent level of multiple correction.PMID:34924458 | DOI:10.1620/tjem.255.325 (Sourc...
Source: The Tohoku Journal of Experimental Medicine - December 20, 2021 Category: Research Authors: Kaori Sakurada Tsuneo Konta Sanae Takahashi Narumi Murakami Hidenori Sato Ryoko Murakami Masafumi Watanabe Kenichi Ishizawa Yoshiyuki Ueno Hidetoshi Yamashita Takamasa Kayama Source Type: research

Circadian Clock Gene Polymorphisms and Sleep-Onset Problems in a Population-Based Cohort Study: The Yamagata Study
This study included 1,397 subjects aged ≥ 40 years who participated in an annual health check-up in Yamagata Prefecture. A total of 80 SNPs of 5 circadian clock genes were analyzed. Multivariate logistic regression analyses identified variant rs11113179 in CRY1 and variants rs1026071 and rs1562438 in BMAL1 as genetic risk factors for sleep induction disorder. These findings suggest that CRY1 and BMAL1 polymorphisms are related to sleep-onset problems in a Japanese general population. However, none of the SNPs remained significant at a stringent level of multiple correction.PMID:34924458 | DOI:10.1620/tjem.255.325 (Sourc...
Source: The Tohoku Journal of Experimental Medicine - December 20, 2021 Category: Research Authors: Kaori Sakurada Tsuneo Konta Sanae Takahashi Narumi Murakami Hidenori Sato Ryoko Murakami Masafumi Watanabe Kenichi Ishizawa Yoshiyuki Ueno Hidetoshi Yamashita Takamasa Kayama Source Type: research

Circadian Clock Gene Polymorphisms and Sleep-Onset Problems in a Population-Based Cohort Study: The Yamagata Study
This study included 1,397 subjects aged ≥ 40 years who participated in an annual health check-up in Yamagata Prefecture. A total of 80 SNPs of 5 circadian clock genes were analyzed. Multivariate logistic regression analyses identified variant rs11113179 in CRY1 and variants rs1026071 and rs1562438 in BMAL1 as genetic risk factors for sleep induction disorder. These findings suggest that CRY1 and BMAL1 polymorphisms are related to sleep-onset problems in a Japanese general population. However, none of the SNPs remained significant at a stringent level of multiple correction.PMID:34924458 | DOI:10.1620/tjem.255.325 (Sourc...
Source: The Tohoku Journal of Experimental Medicine - December 20, 2021 Category: Research Authors: Kaori Sakurada Tsuneo Konta Sanae Takahashi Narumi Murakami Hidenori Sato Ryoko Murakami Masafumi Watanabe Kenichi Ishizawa Yoshiyuki Ueno Hidetoshi Yamashita Takamasa Kayama Source Type: research

Circadian Clock Gene Polymorphisms and Sleep-Onset Problems in a Population-Based Cohort Study: The Yamagata Study
This study included 1,397 subjects aged ≥ 40 years who participated in an annual health check-up in Yamagata Prefecture. A total of 80 SNPs of 5 circadian clock genes were analyzed. Multivariate logistic regression analyses identified variant rs11113179 in CRY1 and variants rs1026071 and rs1562438 in BMAL1 as genetic risk factors for sleep induction disorder. These findings suggest that CRY1 and BMAL1 polymorphisms are related to sleep-onset problems in a Japanese general population. However, none of the SNPs remained significant at a stringent level of multiple correction.PMID:34924458 | DOI:10.1620/tjem.255.325 (Sourc...
Source: The Tohoku Journal of Experimental Medicine - December 20, 2021 Category: Research Authors: Kaori Sakurada Tsuneo Konta Sanae Takahashi Narumi Murakami Hidenori Sato Ryoko Murakami Masafumi Watanabe Kenichi Ishizawa Yoshiyuki Ueno Hidetoshi Yamashita Takamasa Kayama Source Type: research

Circadian Clock Gene Polymorphisms and Sleep-Onset Problems in a Population-Based Cohort Study: The Yamagata Study
This study included 1,397 subjects aged ≥ 40 years who participated in an annual health check-up in Yamagata Prefecture. A total of 80 SNPs of 5 circadian clock genes were analyzed. Multivariate logistic regression analyses identified variant rs11113179 in CRY1 and variants rs1026071 and rs1562438 in BMAL1 as genetic risk factors for sleep induction disorder. These findings suggest that CRY1 and BMAL1 polymorphisms are related to sleep-onset problems in a Japanese general population. However, none of the SNPs remained significant at a stringent level of multiple correction.PMID:34924458 | DOI:10.1620/tjem.255.325 (Sourc...
Source: The Tohoku Journal of Experimental Medicine - December 20, 2021 Category: Research Authors: Kaori Sakurada Tsuneo Konta Sanae Takahashi Narumi Murakami Hidenori Sato Ryoko Murakami Masafumi Watanabe Kenichi Ishizawa Yoshiyuki Ueno Hidetoshi Yamashita Takamasa Kayama Source Type: research

Circadian Clock Gene Polymorphisms and Sleep-Onset Problems in a Population-Based Cohort Study: The Yamagata Study
This study included 1,397 subjects aged ≥ 40 years who participated in an annual health check-up in Yamagata Prefecture. A total of 80 SNPs of 5 circadian clock genes were analyzed. Multivariate logistic regression analyses identified variant rs11113179 in CRY1 and variants rs1026071 and rs1562438 in BMAL1 as genetic risk factors for sleep induction disorder. These findings suggest that CRY1 and BMAL1 polymorphisms are related to sleep-onset problems in a Japanese general population. However, none of the SNPs remained significant at a stringent level of multiple correction.PMID:34924458 | DOI:10.1620/tjem.255.325 (Sourc...
Source: The Tohoku Journal of Experimental Medicine - December 20, 2021 Category: Research Authors: Kaori Sakurada Tsuneo Konta Sanae Takahashi Narumi Murakami Hidenori Sato Ryoko Murakami Masafumi Watanabe Kenichi Ishizawa Yoshiyuki Ueno Hidetoshi Yamashita Takamasa Kayama Source Type: research

Circadian Clock Gene Polymorphisms and Sleep-Onset Problems in a Population-Based Cohort Study: The Yamagata Study
This study included 1,397 subjects aged ≥ 40 years who participated in an annual health check-up in Yamagata Prefecture. A total of 80 SNPs of 5 circadian clock genes were analyzed. Multivariate logistic regression analyses identified variant rs11113179 in CRY1 and variants rs1026071 and rs1562438 in BMAL1 as genetic risk factors for sleep induction disorder. These findings suggest that CRY1 and BMAL1 polymorphisms are related to sleep-onset problems in a Japanese general population. However, none of the SNPs remained significant at a stringent level of multiple correction.PMID:34924458 | DOI:10.1620/tjem.255.325 (Sourc...
Source: The Tohoku Journal of Experimental Medicine - December 20, 2021 Category: Research Authors: Kaori Sakurada Tsuneo Konta Sanae Takahashi Narumi Murakami Hidenori Sato Ryoko Murakami Masafumi Watanabe Kenichi Ishizawa Yoshiyuki Ueno Hidetoshi Yamashita Takamasa Kayama Source Type: research

Circadian Clock Gene Polymorphisms and Sleep-Onset Problems in a Population-Based Cohort Study: The Yamagata Study
This study included 1,397 subjects aged ≥ 40 years who participated in an annual health check-up in Yamagata Prefecture. A total of 80 SNPs of 5 circadian clock genes were analyzed. Multivariate logistic regression analyses identified variant rs11113179 in CRY1 and variants rs1026071 and rs1562438 in BMAL1 as genetic risk factors for sleep induction disorder. These findings suggest that CRY1 and BMAL1 polymorphisms are related to sleep-onset problems in a Japanese general population. However, none of the SNPs remained significant at a stringent level of multiple correction.PMID:34924458 | DOI:10.1620/tjem.255.325 (Sourc...
Source: The Tohoku Journal of Experimental Medicine - December 20, 2021 Category: Research Authors: Kaori Sakurada Tsuneo Konta Sanae Takahashi Narumi Murakami Hidenori Sato Ryoko Murakami Masafumi Watanabe Kenichi Ishizawa Yoshiyuki Ueno Hidetoshi Yamashita Takamasa Kayama Source Type: research

Circadian Clock Gene Polymorphisms and Sleep-Onset Problems in a Population-Based Cohort Study: The Yamagata Study
This study included 1,397 subjects aged ≥ 40 years who participated in an annual health check-up in Yamagata Prefecture. A total of 80 SNPs of 5 circadian clock genes were analyzed. Multivariate logistic regression analyses identified variant rs11113179 in CRY1 and variants rs1026071 and rs1562438 in BMAL1 as genetic risk factors for sleep induction disorder. These findings suggest that CRY1 and BMAL1 polymorphisms are related to sleep-onset problems in a Japanese general population. However, none of the SNPs remained significant at a stringent level of multiple correction.PMID:34924458 | DOI:10.1620/tjem.255.325 (Sourc...
Source: The Tohoku Journal of Experimental Medicine - December 20, 2021 Category: Research Authors: Kaori Sakurada Tsuneo Konta Sanae Takahashi Narumi Murakami Hidenori Sato Ryoko Murakami Masafumi Watanabe Kenichi Ishizawa Yoshiyuki Ueno Hidetoshi Yamashita Takamasa Kayama Source Type: research

Circadian Clock Gene Polymorphisms and Sleep-Onset Problems in a Population-Based Cohort Study: The Yamagata Study
This study included 1,397 subjects aged ≥ 40 years who participated in an annual health check-up in Yamagata Prefecture. A total of 80 SNPs of 5 circadian clock genes were analyzed. Multivariate logistic regression analyses identified variant rs11113179 in CRY1 and variants rs1026071 and rs1562438 in BMAL1 as genetic risk factors for sleep induction disorder. These findings suggest that CRY1 and BMAL1 polymorphisms are related to sleep-onset problems in a Japanese general population. However, none of the SNPs remained significant at a stringent level of multiple correction.PMID:34924458 | DOI:10.1620/tjem.255.325 (Sourc...
Source: The Tohoku Journal of Experimental Medicine - December 20, 2021 Category: Research Authors: Kaori Sakurada Tsuneo Konta Sanae Takahashi Narumi Murakami Hidenori Sato Ryoko Murakami Masafumi Watanabe Kenichi Ishizawa Yoshiyuki Ueno Hidetoshi Yamashita Takamasa Kayama Source Type: research

Circadian Clock Gene Polymorphisms and Sleep-Onset Problems in a Population-Based Cohort Study: The Yamagata Study
This study included 1,397 subjects aged ≥ 40 years who participated in an annual health check-up in Yamagata Prefecture. A total of 80 SNPs of 5 circadian clock genes were analyzed. Multivariate logistic regression analyses identified variant rs11113179 in CRY1 and variants rs1026071 and rs1562438 in BMAL1 as genetic risk factors for sleep induction disorder. These findings suggest that CRY1 and BMAL1 polymorphisms are related to sleep-onset problems in a Japanese general population. However, none of the SNPs remained significant at a stringent level of multiple correction.PMID:34924458 | DOI:10.1620/tjem.255.325 (Sourc...
Source: The Tohoku Journal of Experimental Medicine - December 20, 2021 Category: Research Authors: Kaori Sakurada Tsuneo Konta Sanae Takahashi Narumi Murakami Hidenori Sato Ryoko Murakami Masafumi Watanabe Kenichi Ishizawa Yoshiyuki Ueno Hidetoshi Yamashita Takamasa Kayama Source Type: research

Circadian Clock Gene Polymorphisms and Sleep-Onset Problems in a Population-Based Cohort Study: The Yamagata Study
This study included 1,397 subjects aged ≥ 40 years who participated in an annual health check-up in Yamagata Prefecture. A total of 80 SNPs of 5 circadian clock genes were analyzed. Multivariate logistic regression analyses identified variant rs11113179 in CRY1 and variants rs1026071 and rs1562438 in BMAL1 as genetic risk factors for sleep induction disorder. These findings suggest that CRY1 and BMAL1 polymorphisms are related to sleep-onset problems in a Japanese general population. However, none of the SNPs remained significant at a stringent level of multiple correction.PMID:34924458 | DOI:10.1620/tjem.255.325 (Sourc...
Source: The Tohoku Journal of Experimental Medicine - December 20, 2021 Category: Research Authors: Kaori Sakurada Tsuneo Konta Sanae Takahashi Narumi Murakami Hidenori Sato Ryoko Murakami Masafumi Watanabe Kenichi Ishizawa Yoshiyuki Ueno Hidetoshi Yamashita Takamasa Kayama Source Type: research

Circadian Clock Gene Polymorphisms and Sleep-Onset Problems in a Population-Based Cohort Study: The Yamagata Study
This study included 1,397 subjects aged ≥ 40 years who participated in an annual health check-up in Yamagata Prefecture. A total of 80 SNPs of 5 circadian clock genes were analyzed. Multivariate logistic regression analyses identified variant rs11113179 in CRY1 and variants rs1026071 and rs1562438 in BMAL1 as genetic risk factors for sleep induction disorder. These findings suggest that CRY1 and BMAL1 polymorphisms are related to sleep-onset problems in a Japanese general population. However, none of the SNPs remained significant at a stringent level of multiple correction.PMID:34924458 | DOI:10.1620/tjem.255.325 (Sourc...
Source: The Tohoku Journal of Experimental Medicine - December 20, 2021 Category: Research Authors: Kaori Sakurada Tsuneo Konta Sanae Takahashi Narumi Murakami Hidenori Sato Ryoko Murakami Masafumi Watanabe Kenichi Ishizawa Yoshiyuki Ueno Hidetoshi Yamashita Takamasa Kayama Source Type: research

Circadian Clock Gene Polymorphisms and Sleep-Onset Problems in a Population-Based Cohort Study: The Yamagata Study
This study included 1,397 subjects aged ≥ 40 years who participated in an annual health check-up in Yamagata Prefecture. A total of 80 SNPs of 5 circadian clock genes were analyzed. Multivariate logistic regression analyses identified variant rs11113179 in CRY1 and variants rs1026071 and rs1562438 in BMAL1 as genetic risk factors for sleep induction disorder. These findings suggest that CRY1 and BMAL1 polymorphisms are related to sleep-onset problems in a Japanese general population. However, none of the SNPs remained significant at a stringent level of multiple correction.PMID:34924458 | DOI:10.1620/tjem.255.325 (Sourc...
Source: The Tohoku Journal of Experimental Medicine - December 20, 2021 Category: Research Authors: Kaori Sakurada Tsuneo Konta Sanae Takahashi Narumi Murakami Hidenori Sato Ryoko Murakami Masafumi Watanabe Kenichi Ishizawa Yoshiyuki Ueno Hidetoshi Yamashita Takamasa Kayama Source Type: research

Circadian Clock Gene Polymorphisms and Sleep-Onset Problems in a Population-Based Cohort Study: The Yamagata Study
This study included 1,397 subjects aged ≥ 40 years who participated in an annual health check-up in Yamagata Prefecture. A total of 80 SNPs of 5 circadian clock genes were analyzed. Multivariate logistic regression analyses identified variant rs11113179 in CRY1 and variants rs1026071 and rs1562438 in BMAL1 as genetic risk factors for sleep induction disorder. These findings suggest that CRY1 and BMAL1 polymorphisms are related to sleep-onset problems in a Japanese general population. However, none of the SNPs remained significant at a stringent level of multiple correction.PMID:34924458 | DOI:10.1620/tjem.255.325 (Sourc...
Source: The Tohoku Journal of Experimental Medicine - December 20, 2021 Category: Research Authors: Kaori Sakurada Tsuneo Konta Sanae Takahashi Narumi Murakami Hidenori Sato Ryoko Murakami Masafumi Watanabe Kenichi Ishizawa Yoshiyuki Ueno Hidetoshi Yamashita Takamasa Kayama Source Type: research

Circadian Clock Gene Polymorphisms and Sleep-Onset Problems in a Population-Based Cohort Study: The Yamagata Study
This study included 1,397 subjects aged ≥ 40 years who participated in an annual health check-up in Yamagata Prefecture. A total of 80 SNPs of 5 circadian clock genes were analyzed. Multivariate logistic regression analyses identified variant rs11113179 in CRY1 and variants rs1026071 and rs1562438 in BMAL1 as genetic risk factors for sleep induction disorder. These findings suggest that CRY1 and BMAL1 polymorphisms are related to sleep-onset problems in a Japanese general population. However, none of the SNPs remained significant at a stringent level of multiple correction.PMID:34924458 | DOI:10.1620/tjem.255.325 (Sourc...
Source: The Tohoku Journal of Experimental Medicine - December 20, 2021 Category: Research Authors: Kaori Sakurada Tsuneo Konta Sanae Takahashi Narumi Murakami Hidenori Sato Ryoko Murakami Masafumi Watanabe Kenichi Ishizawa Yoshiyuki Ueno Hidetoshi Yamashita Takamasa Kayama Source Type: research

Circadian Clock Gene Polymorphisms and Sleep-Onset Problems in a Population-Based Cohort Study: The Yamagata Study
This study included 1,397 subjects aged ≥ 40 years who participated in an annual health check-up in Yamagata Prefecture. A total of 80 SNPs of 5 circadian clock genes were analyzed. Multivariate logistic regression analyses identified variant rs11113179 in CRY1 and variants rs1026071 and rs1562438 in BMAL1 as genetic risk factors for sleep induction disorder. These findings suggest that CRY1 and BMAL1 polymorphisms are related to sleep-onset problems in a Japanese general population. However, none of the SNPs remained significant at a stringent level of multiple correction.PMID:34924458 | DOI:10.1620/tjem.255.325 (Sourc...
Source: The Tohoku Journal of Experimental Medicine - December 20, 2021 Category: Research Authors: Kaori Sakurada Tsuneo Konta Sanae Takahashi Narumi Murakami Hidenori Sato Ryoko Murakami Masafumi Watanabe Kenichi Ishizawa Yoshiyuki Ueno Hidetoshi Yamashita Takamasa Kayama Source Type: research

The Impact of Histological Subtype on Survival Outcome of Patients with Stage IIB-IVA Cervical Cancer Who Received Definitive Radiotherapy
Tohoku J Exp Med. 2021;255(4):303-313. doi: 10.1620/tjem.255.303.ABSTRACTThe impact of histologic subtype on definitive radiotherapy for patients with locally advanced cervical cancer remains unclear. The aim of this retrospective analysis was to assess clinicopathological findings and clinical outcome by histological type in patients with stage IIB-IVA cervical cancer. Ninety-two patients with stage IIB-IVA [International Federation of Gynecology and Obstetrics (FIGO) 2008] cervical cancer, who underwent definitive radiotherapy between 2013 to 2018, were identified as eligible for this study. The clinical information of t...
Source: The Tohoku Journal of Experimental Medicine - December 16, 2021 Category: Research Authors: Shuko Miyahara Keita Tsuji Muneaki Shimada Yusuke Shibuya Shogo Shigeta Tomoyuki Nagai Rei Umezawa Hideki Tokunaga Keiichi Jingu Nobuo Yaegashi Source Type: research

Analyzing Correlation of Clinical Severity of COVID-19 with Other Biochemical Parameters: A Retrospective Study from Pakistan
This study observed that coronavirus disease 2019 (COVID-19) was more likely in individuals aged 51-60 than 61-70. In addition, our study found that COVID-19 patients exhibited a statistically significant increase in levels of ferritin, D-dimers, LDH, and CRP. In addition, this study found that COVID-19 patients had significantly higher levels of ferritin, D-dimers, LDH, and CRP. Our study revealed that SARS-CoV-2 relapsed. Furthermore, we concluded that these biochemical parameters are useful indicators for severity of COVID-19.PMID:34911879 | DOI:10.1620/tjem.255.315 (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - December 16, 2021 Category: Research Authors: Syed Sib Tul Hassan Shah Iqra Naeem Braira Wahid Source Type: research

Tubular Injury Causing Protracted Glycosuria Following Withdrawal of a Sodium-Glucose Cotransporter 2 (SGLT2) Inhibitor: A Possible Role in the Development of Protracted Hypoglycemia and Ketoacidosis
Tohoku J Exp Med. 2021;255(4):291-296. doi: 10.1620/tjem.255.291.ABSTRACTWe herein present the case of a 45-year-old diabetic woman who developed diabetic ketoacidosis following the administration of dapagliflozin, a sodium-glucose cotransporter 2 (SGLT2) inhibitor. The patient had been diagnosed with diabetes three years previously and was being treated with multiple daily injections of insulin. Metformin hydrochloride and dapagliflozin were added seven months and 11 months later, respectively. Her clinical course was uneventful until the onset of influenza. She then discontinued insulin and oral medications voluntarily. ...
Source: The Tohoku Journal of Experimental Medicine - December 16, 2021 Category: Research Authors: Rika Hashi Noritaka Fujiki Toshihito Yagi Source Type: research

The Impact of Histological Subtype on Survival Outcome of Patients with Stage IIB-IVA Cervical Cancer Who Received Definitive Radiotherapy
Tohoku J Exp Med. 2021;255(4):303-313. doi: 10.1620/tjem.255.303.ABSTRACTThe impact of histologic subtype on definitive radiotherapy for patients with locally advanced cervical cancer remains unclear. The aim of this retrospective analysis was to assess clinicopathological findings and clinical outcome by histological type in patients with stage IIB-IVA cervical cancer. Ninety-two patients with stage IIB-IVA [International Federation of Gynecology and Obstetrics (FIGO) 2008] cervical cancer, who underwent definitive radiotherapy between 2013 to 2018, were identified as eligible for this study. The clinical information of t...
Source: The Tohoku Journal of Experimental Medicine - December 16, 2021 Category: Research Authors: Shuko Miyahara Keita Tsuji Muneaki Shimada Yusuke Shibuya Shogo Shigeta Tomoyuki Nagai Rei Umezawa Hideki Tokunaga Keiichi Jingu Nobuo Yaegashi Source Type: research

Analyzing Correlation of Clinical Severity of COVID-19 with Other Biochemical Parameters: A Retrospective Study from Pakistan
This study observed that coronavirus disease 2019 (COVID-19) was more likely in individuals aged 51-60 than 61-70. In addition, our study found that COVID-19 patients exhibited a statistically significant increase in levels of ferritin, D-dimers, LDH, and CRP. In addition, this study found that COVID-19 patients had significantly higher levels of ferritin, D-dimers, LDH, and CRP. Our study revealed that SARS-CoV-2 relapsed. Furthermore, we concluded that these biochemical parameters are useful indicators for severity of COVID-19.PMID:34911879 | DOI:10.1620/tjem.255.315 (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - December 16, 2021 Category: Research Authors: Syed Sib Tul Hassan Shah Iqra Naeem Braira Wahid Source Type: research

Tubular Injury Causing Protracted Glycosuria Following Withdrawal of a Sodium-Glucose Cotransporter 2 (SGLT2) Inhibitor: A Possible Role in the Development of Protracted Hypoglycemia and Ketoacidosis
Tohoku J Exp Med. 2021;255(4):291-296. doi: 10.1620/tjem.255.291.ABSTRACTWe herein present the case of a 45-year-old diabetic woman who developed diabetic ketoacidosis following the administration of dapagliflozin, a sodium-glucose cotransporter 2 (SGLT2) inhibitor. The patient had been diagnosed with diabetes three years previously and was being treated with multiple daily injections of insulin. Metformin hydrochloride and dapagliflozin were added seven months and 11 months later, respectively. Her clinical course was uneventful until the onset of influenza. She then discontinued insulin and oral medications voluntarily. ...
Source: The Tohoku Journal of Experimental Medicine - December 16, 2021 Category: Research Authors: Rika Hashi Noritaka Fujiki Toshihito Yagi Source Type: research

The Impact of Histological Subtype on Survival Outcome of Patients with Stage IIB-IVA Cervical Cancer Who Received Definitive Radiotherapy
Tohoku J Exp Med. 2021;255(4):303-313. doi: 10.1620/tjem.255.303.ABSTRACTThe impact of histologic subtype on definitive radiotherapy for patients with locally advanced cervical cancer remains unclear. The aim of this retrospective analysis was to assess clinicopathological findings and clinical outcome by histological type in patients with stage IIB-IVA cervical cancer. Ninety-two patients with stage IIB-IVA [International Federation of Gynecology and Obstetrics (FIGO) 2008] cervical cancer, who underwent definitive radiotherapy between 2013 to 2018, were identified as eligible for this study. The clinical information of t...
Source: The Tohoku Journal of Experimental Medicine - December 16, 2021 Category: Research Authors: Shuko Miyahara Keita Tsuji Muneaki Shimada Yusuke Shibuya Shogo Shigeta Tomoyuki Nagai Rei Umezawa Hideki Tokunaga Keiichi Jingu Nobuo Yaegashi Source Type: research

Analyzing Correlation of Clinical Severity of COVID-19 with Other Biochemical Parameters: A Retrospective Study from Pakistan
This study observed that coronavirus disease 2019 (COVID-19) was more likely in individuals aged 51-60 than 61-70. In addition, our study found that COVID-19 patients exhibited a statistically significant increase in levels of ferritin, D-dimers, LDH, and CRP. In addition, this study found that COVID-19 patients had significantly higher levels of ferritin, D-dimers, LDH, and CRP. Our study revealed that SARS-CoV-2 relapsed. Furthermore, we concluded that these biochemical parameters are useful indicators for severity of COVID-19.PMID:34911879 | DOI:10.1620/tjem.255.315 (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - December 16, 2021 Category: Research Authors: Syed Sib Tul Hassan Shah Iqra Naeem Braira Wahid Source Type: research

Tubular Injury Causing Protracted Glycosuria Following Withdrawal of a Sodium-Glucose Cotransporter 2 (SGLT2) Inhibitor: A Possible Role in the Development of Protracted Hypoglycemia and Ketoacidosis
Tohoku J Exp Med. 2021;255(4):291-296. doi: 10.1620/tjem.255.291.ABSTRACTWe herein present the case of a 45-year-old diabetic woman who developed diabetic ketoacidosis following the administration of dapagliflozin, a sodium-glucose cotransporter 2 (SGLT2) inhibitor. The patient had been diagnosed with diabetes three years previously and was being treated with multiple daily injections of insulin. Metformin hydrochloride and dapagliflozin were added seven months and 11 months later, respectively. Her clinical course was uneventful until the onset of influenza. She then discontinued insulin and oral medications voluntarily. ...
Source: The Tohoku Journal of Experimental Medicine - December 16, 2021 Category: Research Authors: Rika Hashi Noritaka Fujiki Toshihito Yagi Source Type: research

The Impact of Histological Subtype on Survival Outcome of Patients with Stage IIB-IVA Cervical Cancer Who Received Definitive Radiotherapy
Tohoku J Exp Med. 2021;255(4):303-313. doi: 10.1620/tjem.255.303.ABSTRACTThe impact of histologic subtype on definitive radiotherapy for patients with locally advanced cervical cancer remains unclear. The aim of this retrospective analysis was to assess clinicopathological findings and clinical outcome by histological type in patients with stage IIB-IVA cervical cancer. Ninety-two patients with stage IIB-IVA [International Federation of Gynecology and Obstetrics (FIGO) 2008] cervical cancer, who underwent definitive radiotherapy between 2013 to 2018, were identified as eligible for this study. The clinical information of t...
Source: The Tohoku Journal of Experimental Medicine - December 16, 2021 Category: Research Authors: Shuko Miyahara Keita Tsuji Muneaki Shimada Yusuke Shibuya Shogo Shigeta Tomoyuki Nagai Rei Umezawa Hideki Tokunaga Keiichi Jingu Nobuo Yaegashi Source Type: research

Analyzing Correlation of Clinical Severity of COVID-19 with Other Biochemical Parameters: A Retrospective Study from Pakistan
This study observed that coronavirus disease 2019 (COVID-19) was more likely in individuals aged 51-60 than 61-70. In addition, our study found that COVID-19 patients exhibited a statistically significant increase in levels of ferritin, D-dimers, LDH, and CRP. In addition, this study found that COVID-19 patients had significantly higher levels of ferritin, D-dimers, LDH, and CRP. Our study revealed that SARS-CoV-2 relapsed. Furthermore, we concluded that these biochemical parameters are useful indicators for severity of COVID-19.PMID:34911879 | DOI:10.1620/tjem.255.315 (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - December 16, 2021 Category: Research Authors: Syed Sib Tul Hassan Shah Iqra Naeem Braira Wahid Source Type: research

Tubular Injury Causing Protracted Glycosuria Following Withdrawal of a Sodium-Glucose Cotransporter 2 (SGLT2) Inhibitor: A Possible Role in the Development of Protracted Hypoglycemia and Ketoacidosis
Tohoku J Exp Med. 2021;255(4):291-296. doi: 10.1620/tjem.255.291.ABSTRACTWe herein present the case of a 45-year-old diabetic woman who developed diabetic ketoacidosis following the administration of dapagliflozin, a sodium-glucose cotransporter 2 (SGLT2) inhibitor. The patient had been diagnosed with diabetes three years previously and was being treated with multiple daily injections of insulin. Metformin hydrochloride and dapagliflozin were added seven months and 11 months later, respectively. Her clinical course was uneventful until the onset of influenza. She then discontinued insulin and oral medications voluntarily. ...
Source: The Tohoku Journal of Experimental Medicine - December 16, 2021 Category: Research Authors: Rika Hashi Noritaka Fujiki Toshihito Yagi Source Type: research

Workplace Bullying and Patient Aggression Related to COVID-19 and its Association with Psychological Distress among Health Care Professionals during the COVID-19 Pandemic in Japan
This study examined the prevalence of COVID-19-related workplace bullying and patient aggression and its association with psychological distress among healthcare professionals during the COVID-19 outbreak in Japan. This was a cross-sectional study conducted from May 22 to 26, 2020, inviting participants (n = 1,421) from an online survey of full-time employees. We limited the sample to healthcare professionals for further analyses. Using an online self-report questionnaire, workplace bullying and patient aggression related to COVID-19 was measured using nine items with dichotomous response options. Psychological distress wa...
Source: The Tohoku Journal of Experimental Medicine - December 13, 2021 Category: Research Authors: Hiroki Asaoka Natsu Sasaki Reiko Kuroda Kanami Tsuno Norito Kawakami Source Type: research

Adult-Onset Still's Disease Complicated by Immunoglobulin A Vasculitis and anti-CCP Antibody-Positive Arthritis
Tohoku J Exp Med. 2021;255(4):297-301. doi: 10.1620/tjem.255.297.ABSTRACTA 38-year-old male was admitted to our hospital for arthralgia, fever, skin rash, and purpura. He was diagnosed as having adult-onset Still's disease (AOSD) based on Yamaguchi's criteria. Skin biopsy revealed immunoglobulin A (IgA) vasculitis. He was also found to have anti-cyclic citrullinated peptide (CCP) antibody-positive inflammatory arthritis on a shoulder joint, however he did not fulfill classification criteria for rheumatoid arthritis. Elevated serum cytokine such as serum IL-18 supported the diagnosis of AOSD. His symptoms improved with 40 m...
Source: The Tohoku Journal of Experimental Medicine - December 13, 2021 Category: Research Authors: Yuya Fujita Shuzo Sato Haruki Matsumoto Jumpei Temmoku Makiko Yashiro-Furuya Naoki Matsuoka Tomoyuki Asano Kohei Yokose Shuhei Yoshida Mikio Ohtsuka Hiroshi Watanabe Kiyoshi Migita Source Type: research

Workplace Bullying and Patient Aggression Related to COVID-19 and its Association with Psychological Distress among Health Care Professionals during the COVID-19 Pandemic in Japan
This study examined the prevalence of COVID-19-related workplace bullying and patient aggression and its association with psychological distress among healthcare professionals during the COVID-19 outbreak in Japan. This was a cross-sectional study conducted from May 22 to 26, 2020, inviting participants (n = 1,421) from an online survey of full-time employees. We limited the sample to healthcare professionals for further analyses. Using an online self-report questionnaire, workplace bullying and patient aggression related to COVID-19 was measured using nine items with dichotomous response options. Psychological distress wa...
Source: The Tohoku Journal of Experimental Medicine - December 13, 2021 Category: Research Authors: Hiroki Asaoka Natsu Sasaki Reiko Kuroda Kanami Tsuno Norito Kawakami Source Type: research

Adult-Onset Still's Disease Complicated by Immunoglobulin A Vasculitis and anti-CCP Antibody-Positive Arthritis
Tohoku J Exp Med. 2021;255(4):297-301. doi: 10.1620/tjem.255.297.ABSTRACTA 38-year-old male was admitted to our hospital for arthralgia, fever, skin rash, and purpura. He was diagnosed as having adult-onset Still's disease (AOSD) based on Yamaguchi's criteria. Skin biopsy revealed immunoglobulin A (IgA) vasculitis. He was also found to have anti-cyclic citrullinated peptide (CCP) antibody-positive inflammatory arthritis on a shoulder joint, however he did not fulfill classification criteria for rheumatoid arthritis. Elevated serum cytokine such as serum IL-18 supported the diagnosis of AOSD. His symptoms improved with 40 m...
Source: The Tohoku Journal of Experimental Medicine - December 13, 2021 Category: Research Authors: Yuya Fujita Shuzo Sato Haruki Matsumoto Jumpei Temmoku Makiko Yashiro-Furuya Naoki Matsuoka Tomoyuki Asano Kohei Yokose Shuhei Yoshida Mikio Ohtsuka Hiroshi Watanabe Kiyoshi Migita Source Type: research

Workplace Bullying and Patient Aggression Related to COVID-19 and its Association with Psychological Distress among Health Care Professionals during the COVID-19 Pandemic in Japan
This study examined the prevalence of COVID-19-related workplace bullying and patient aggression and its association with psychological distress among healthcare professionals during the COVID-19 outbreak in Japan. This was a cross-sectional study conducted from May 22 to 26, 2020, inviting participants (n = 1,421) from an online survey of full-time employees. We limited the sample to healthcare professionals for further analyses. Using an online self-report questionnaire, workplace bullying and patient aggression related to COVID-19 was measured using nine items with dichotomous response options. Psychological distress wa...
Source: The Tohoku Journal of Experimental Medicine - December 13, 2021 Category: Research Authors: Hiroki Asaoka Natsu Sasaki Reiko Kuroda Kanami Tsuno Norito Kawakami Source Type: research

Adult-Onset Still's Disease Complicated by Immunoglobulin A Vasculitis and anti-CCP Antibody-Positive Arthritis
Tohoku J Exp Med. 2021;255(4):297-301. doi: 10.1620/tjem.255.297.ABSTRACTA 38-year-old male was admitted to our hospital for arthralgia, fever, skin rash, and purpura. He was diagnosed as having adult-onset Still's disease (AOSD) based on Yamaguchi's criteria. Skin biopsy revealed immunoglobulin A (IgA) vasculitis. He was also found to have anti-cyclic citrullinated peptide (CCP) antibody-positive inflammatory arthritis on a shoulder joint, however he did not fulfill classification criteria for rheumatoid arthritis. Elevated serum cytokine such as serum IL-18 supported the diagnosis of AOSD. His symptoms improved with 40 m...
Source: The Tohoku Journal of Experimental Medicine - December 13, 2021 Category: Research Authors: Yuya Fujita Shuzo Sato Haruki Matsumoto Jumpei Temmoku Makiko Yashiro-Furuya Naoki Matsuoka Tomoyuki Asano Kohei Yokose Shuhei Yoshida Mikio Ohtsuka Hiroshi Watanabe Kiyoshi Migita Source Type: research

Evaluation of the Utility of Mitochondrial DNA Testing in Personal Identification Work in the Great East Japan Earthquake of 2011
Tohoku J Exp Med. 2021;255(4):275-281. doi: 10.1620/tjem.255.275.ABSTRACTAlthough the Great East Japan Earthquake occurred on March 11, 2011, identification of victims is still ongoing. Typically, mitochondrial DNA (mtDNA) is performed when it is difficult to identify an individual using nuclear DNA. In Japan, samples from criminal investigations are subjected to nuclear DNA testing at the Scientific Research Institute belonging to each prefectural police headquarters, while all mtDNA tests were originally conducted at the National Research Institute of Police Science. However, the appraisal work using mtDNA became more ti...
Source: The Tohoku Journal of Experimental Medicine - December 9, 2021 Category: Research Authors: Tsukasa Ohuchi Xueting Guan Masato Funayama Source Type: research

Evaluation of the Utility of Mitochondrial DNA Testing in Personal Identification Work in the Great East Japan Earthquake of 2011
Tohoku J Exp Med. 2021;255(4):275-281. doi: 10.1620/tjem.255.275.ABSTRACTAlthough the Great East Japan Earthquake occurred on March 11, 2011, identification of victims is still ongoing. Typically, mitochondrial DNA (mtDNA) is performed when it is difficult to identify an individual using nuclear DNA. In Japan, samples from criminal investigations are subjected to nuclear DNA testing at the Scientific Research Institute belonging to each prefectural police headquarters, while all mtDNA tests were originally conducted at the National Research Institute of Police Science. However, the appraisal work using mtDNA became more ti...
Source: The Tohoku Journal of Experimental Medicine - December 9, 2021 Category: Research Authors: Tsukasa Ohuchi Xueting Guan Masato Funayama Source Type: research

Evaluation of the Utility of Mitochondrial DNA Testing in Personal Identification Work in the Great East Japan Earthquake of 2011
Tohoku J Exp Med. 2021;255(4):275-281. doi: 10.1620/tjem.255.275.ABSTRACTAlthough the Great East Japan Earthquake occurred on March 11, 2011, identification of victims is still ongoing. Typically, mitochondrial DNA (mtDNA) is performed when it is difficult to identify an individual using nuclear DNA. In Japan, samples from criminal investigations are subjected to nuclear DNA testing at the Scientific Research Institute belonging to each prefectural police headquarters, while all mtDNA tests were originally conducted at the National Research Institute of Police Science. However, the appraisal work using mtDNA became more ti...
Source: The Tohoku Journal of Experimental Medicine - December 9, 2021 Category: Research Authors: Tsukasa Ohuchi Xueting Guan Masato Funayama Source Type: research

Evaluation of the Utility of Mitochondrial DNA Testing in Personal Identification Work in the Great East Japan Earthquake of 2011
Tohoku J Exp Med. 2021;255(4):275-281. doi: 10.1620/tjem.255.275.ABSTRACTAlthough the Great East Japan Earthquake occurred on March 11, 2011, identification of victims is still ongoing. Typically, mitochondrial DNA (mtDNA) is performed when it is difficult to identify an individual using nuclear DNA. In Japan, samples from criminal investigations are subjected to nuclear DNA testing at the Scientific Research Institute belonging to each prefectural police headquarters, while all mtDNA tests were originally conducted at the National Research Institute of Police Science. However, the appraisal work using mtDNA became more ti...
Source: The Tohoku Journal of Experimental Medicine - December 9, 2021 Category: Research Authors: Tsukasa Ohuchi Xueting Guan Masato Funayama Source Type: research

Use of Medical Information and Digital Services for Self-Empowerment before, during, and after a Major Disaster
Tohoku J Exp Med. 2021 Nov;255(3):183-194. doi: 10.1620/tjem.255.183.ABSTRACTDisaster response procedures have been developed and improved following the Great East Japan Earthquake. Innovative services have also been created through digital transformation, including an acceleration and deepening of artificial intelligence technology. Things that were once technically impossible are now possible. These innovative technologies will spread across various fields, and disaster response will not be an exception. The Ministry of Health, Labour and Welfare is promoting the use of personal health records in a way that effectively s...
Source: The Tohoku Journal of Experimental Medicine - December 2, 2021 Category: Research Authors: Susumu Fujii Sayuri Nonaka Masaharu Nakayama Source Type: research

Comprehensive Analysis of Serum Metabolites Profiles in Acute Radiation Enteritis Rats by Untargeted Metabolomics
Tohoku J Exp Med. 2021 Nov;255(3):257-265. doi: 10.1620/tjem.255.257.ABSTRACTAcute radiation enteritis is a common complication occurring in patients with pelvic and abdominal tumors who receive radiotherapy. Acute radiation enteritis seriously reduces the life quality, even threatens the lives of patients. Untargeted metabolomics is an emerging strategy to explore the novel biomarkers and uncover potential pathogenesis of acute radiation enteritis. Acute radiation enteritis rat model was established by single abdominal irradiation with a gamma-ray dose of 10 Gy. Serum from 15 acute radiation enteritis rats and 10 controls...
Source: The Tohoku Journal of Experimental Medicine - December 2, 2021 Category: Research Authors: He Nie Jiadong Pan Fangmei An Chuwei Zheng Qinglin Zhang Qiang Zhan Source Type: research

Diagnosis and Management of Coronavirus Disease 2019 (COVID-19): Patients with Presented with Abdominal Pain, Fever and Shortness of Breath in Pandemic
Tohoku J Exp Med. 2021 Nov;255(3):267-273. doi: 10.1620/tjem.255.267.ABSTRACTThe aim of this study was to evaluate the admission chest and abdominal computed tomography (CT) findings of patients who presented to the emergency department with complaints of abdominal pain, fever, and shortness of breath and who had RT-PCR-confirmed COVID-19 infection. Seventy-five patients with RT-PCR-confirmed (in laboratory) COVID-19 infection who underwent chest and abdominal CT were included in the study. The radiological scales [the COVID-19 Reporting and Data System (CO-RADS) and severity score] of the chest and abdominal findings were...
Source: The Tohoku Journal of Experimental Medicine - December 2, 2021 Category: Research Authors: Mehmet Mustafa Alt ıntaş Ay şegül Karadayı Büyüközsoy Ömer Aydıner Source Type: research

Use of Medical Information and Digital Services for Self-Empowerment before, during, and after a Major Disaster
Tohoku J Exp Med. 2021 Nov;255(3):183-194. doi: 10.1620/tjem.255.183.ABSTRACTDisaster response procedures have been developed and improved following the Great East Japan Earthquake. Innovative services have also been created through digital transformation, including an acceleration and deepening of artificial intelligence technology. Things that were once technically impossible are now possible. These innovative technologies will spread across various fields, and disaster response will not be an exception. The Ministry of Health, Labour and Welfare is promoting the use of personal health records in a way that effectively s...
Source: The Tohoku Journal of Experimental Medicine - December 2, 2021 Category: Research Authors: Susumu Fujii Sayuri Nonaka Masaharu Nakayama Source Type: research