High Relapse Rate in Patients with Polymyalgia Rheumatica despite the Combination of Immunosuppressants and Prednisolone: A Single Center Experience of 89 patients.
Abstract Polymyalgia rheumatica (PMR) is an inflammatory disorder in the elderly and is characterized by pain in the shoulders and lower back. Previous studies from western countries have shown that relapse is frequent; however, there are only a few reports on the relapse rate in Japan. Here we examined the relapse rate, and sought to identify factors that predict recurrence in patients with PMR. Of 110 patients who fulfilled the Bird's criteria for PMR between May 2011 and June 2019, 21 patients were excluded, and the remaining 89 patients were followed up until July 2019. Relapse was defined when clinical sympto...
Source: The Tohoku Journal of Experimental Medicine - June 26, 2020 Category: Research Authors: Okazaki S, Watanabe R, Kondo H, Kudo M, Harigae H, Fujii H Tags: Tohoku J Exp Med Source Type: research

Serum Mannose-Binding Lectin Levels Are Correlated with the Disease Activity of Antineutrophil Cytoplasmic Antibody-Associated Vasculitis: A Single-Center Study.
In this study, we investigated whether serum MBL is associated with disease activity of AAV, which was measured by ELISA. Associations between serum MBL and AAV-specific indices, as well as clinical and laboratory data were assessed using Kendall's tau. Among the 80 patients, 42 (52.5%), 21 (26.3), and 17 (21.3%) patients were classified as microscopic polyangiitis (MPA), granulomatosis with polyangiitis (GPA), and eosinophilic granulomatosis with polyangiitis (EGPA), respectively. The median values of erythrocyte sedimentation rate, C-reactive protein, and serum MBL were 36.5 (normal range
Source: The Tohoku Journal of Experimental Medicine - June 26, 2020 Category: Research Authors: Yoon T, Ahn SS, Yoo J, Yoo BW, Kwon HC, Jung SM, Song JJ, Park YB, Lee SW Tags: Tohoku J Exp Med Source Type: research

Impressions of Interfaith Chaplain's Activities among Patients in a Palliative Care Unit: A Semi-Structured Interview-Based Qualitative Study.
In conclusion, the interfaith chaplain is deemed helpful by the interviewed patients in relieving their anxieties. PMID: 32581192 [PubMed - in process] (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - June 26, 2020 Category: Research Authors: Hiratsuka Y, Aoyama M, Kaneta T, Masukawa K, Tagami K, Miyashita M, Inoue A Tags: Tohoku J Exp Med Source Type: research

Design and Progress of Oral Health Examinations in the Tohoku Medical Megabank Project.
i T, Ogishima S, Nakamura T, Sakurai-Yageta M, Nagami F, Kinoshita K, Kure S, Shimizu R, Sasaki K, Yamamoto M Abstract In order to assess the long-term impact of the Great East Japan Earthquake on the oral health of disaster victims and to evaluate gene-environmental interactions in the development of major oral diseases and oral-systemic associations, the oral part of two large-scale genome cohort studies by the Tohoku Medical Megabank Organization (ToMMo), including the Community-based cohort (CommCohort) study and the Birth and Three-Generation cohort (BirThree) study, have been conducted. The study population ...
Source: The Tohoku Journal of Experimental Medicine - June 26, 2020 Category: Research Authors: Tsuboi A, Matsui H, Shiraishi N, Murakami T, Otsuki A, Kawashima J, Kiyama T, Tamahara T, Goto M, Koyama S, Sugawara J, Kodama EN, Metoki H, Hozawa A, Kuriyama S, Tomita H, Kikuya M, Minegishi N, Suzuki K, Koshiba S, Tamiya G, Fuse N, Aoki Y, Takai-Igaras Tags: Tohoku J Exp Med Source Type: research

Uric Acid Elevation by Favipiravir, an Antiviral Drug.
Abstract In light of the recent pandemic, favipiravir (Avigan®), a purine nucleic acid analog and antiviral agent approved for use in influenza in Japan, is being studied for the treatment of coronavirus disease 2019 (COVID-19). Increase in blood uric acid level is a frequent side effect of favipiravir. Here, we discussed the mechanism of blood uric acid elevation during favipiravir treatment. Favipiravir is metabolized to an inactive metabolite M1 by aldehyde oxidase and xanthine oxidase, and excreted into urine. In the kidney, uric acid handling is regulated by the balance of reabsorption and tubular secreti...
Source: The Tohoku Journal of Experimental Medicine - June 18, 2020 Category: Research Authors: Mishima E, Anzai N, Miyazaki M, Abe T Tags: Tohoku J Exp Med Source Type: research

Successful Anti-TNF-Alpha Therapy for Crohn's Disease After Allogeneic Stem Cell Transplantation: A Case Report.
Abstract Graft-versus-host disease (GVHD) is a potentially life-threatening complication of allogeneic stem cell transplantation (Allo-SCT). Chronic GVHD, which typically presents more than 100 days after Allo-SCT, can resemble manifestations of autoimmune disease; however, there are only a few reports on the development of Crohn's disease (CD) after Allo-SCT. Here, we report a case of steroid-refractory CD after umbilical cord blood transplantation (CBT), which was dramatically improved with administration of anti-tumor necrosis factor-alpha (anti-TNF-alpha) antibodies. A 21-year-old woman with refractory Hodgkin...
Source: The Tohoku Journal of Experimental Medicine - June 9, 2020 Category: Research Authors: Kamachi K, Ando T, Tsuruoka N, Hashiguchi M, Kidoguchi K, Kusaba K, Sano H, Sano H, Yamaguchi K, Nishioka A, Yoshimura M, Yokoo M, Kubota Y, Kojima K, Kimura S Tags: Tohoku J Exp Med Source Type: research

Cardiac Resynchronization Therapy for Improving Non-Uniform Thickening of Left Ventricular Wall: Assessment by Quantitative Gated Myocardial Perfusion SPECT.
In conclusion, CRT improved non-uniformity of wall thickening between the LV septal and lateral regions evaluated using QGS, which is predictive of better prognosis in the chronic phase after CRT. PMID: 32493869 [PubMed - in process] (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - June 6, 2020 Category: Research Authors: Wakayama Y, Nakano M, Fukuda K, Kumagai K, Sugai Y, Hirose M, Yamaguchi N, Kondo M, Kaneta T, Fukuda H, Kagaya Y, Shimokawa H Tags: Tohoku J Exp Med Source Type: research

Cholesterol Emboli Co-Existing with Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis in a 76-Year-Old Woman.
We report a case of ANCA-associated vasculitis coexisting with cholesterol emboli. A 76-year-old woman was diagnosed with ANCA-associated interstitial pneumonitis. She rapidly developed progressive glomerulonephritis, purpura, and peripheral sensory nerve disorder. A kidney biopsy revealed that renal dysfunction was caused by vasculitis of the interlobular arteries and cholesterol emboli. A skin biopsy revealed that purpura was caused by cholesterol emboli. Glucocorticoid and statin therapies were administered. Thereafter, the renal function and other symptoms improved and stabilized. The representative symptoms of ANCA-as...
Source: The Tohoku Journal of Experimental Medicine - June 2, 2020 Category: Research Authors: Kojima R, Harada M, Yamaguchi A, Hashimoto K, Kamijo Y Tags: Tohoku J Exp Med Source Type: research

COVID-19 Waves: Importance of Accumulative Mortality per Million Inhabitants.
Abstract The reported number of new cases underestimates the real spread of COVID-19 pandemic because of non-tested asymptomatic people and limited global access to reliable diagnostic tests. In this context, COVID-19 mortality with confirmed diagnosis becomes an attractive source of information to be included in the analysis of perspectives and proposals. Objective data are required to calculate the capacity of resources provided by health systems. New strategies are needed to stabilize or minimize the mortality surge. However, we will not afford this goal until more alternatives were available. We still need an ...
Source: The Tohoku Journal of Experimental Medicine - May 30, 2020 Category: Research Authors: Delgado CA, Shimabuku RL, Chiroque-Solano PM Tags: Tohoku J Exp Med Source Type: research

Association between Adult Height and Risk of Lung Cancer Incidence among Japanese Men: The Miyagi Cohort Study.
Abstract It is already known that adult height is a factor associated with an increased risk of colon cancer and postmenopausal breast cancer, pancreatic cancer, premenopausal breast cancer, and ovarian cancer. However, the association between adult height and lung cancer incidence remains unclear. The purpose of the present study was to examine the association between adult height and the risk of lung cancer incidence in the Japanese population. We analyzed data for 43,743 men and women who were 40-64 years old at the baseline in 1990. We divided the participants into quintiles based on height at the baseline. Co...
Source: The Tohoku Journal of Experimental Medicine - May 30, 2020 Category: Research Authors: Mugikura M, Sugawara Y, Tomata Y, Kanemura S, Fukao A, Tsuji I Tags: Tohoku J Exp Med Source Type: research

Protease Inhibitors: Candidate Drugs to Inhibit Severe Acute Respiratory Syndrome Coronavirus 2 Replication.
Abstract The number of patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly increased, although the WHO declared a pandemic. However, drugs that function against SARS-CoV-2 have not been established. SARS-CoV-2 has been suggested to bind angiotensin-converting enzyme 2, the receptor of the SARS coronavirus. SARS coronavirus and coronavirus 229E, the cause of the common cold, replicate through cell-surface and endosomal pathways using a protease, the type II transmembrane protease. To examine the effects of protease inhibitors on the replication of coronavirus 229E, we pre...
Source: The Tohoku Journal of Experimental Medicine - May 27, 2020 Category: Research Authors: Yamaya M, Nishimura H, Deng X, Kikuchi A, Nagatomi R Tags: Tohoku J Exp Med Source Type: research

Higher Incidence of Syphilis among Patients with HIV Infection: Population Study using Surveillance Data of Tokyo, Japan.
The objective of this study was to evaluate the risk of HIV infection for syphilis co-infection on the population of Tokyo, Japan. We analyzed data of syphilis cases obtained from additional surveillance by the Tokyo Metropolitan Government in 2018, including those with human immunodeficiency virus (HIV) infection as well as data of HIV/acquired immunodeficiency syndrome (AIDS) cases during 1985-2017. We calculated the incidence of symptomatic syphilis cases among HIV-infected or non-HIV-infected individuals. Similarly, we calculated the incidence of syphilis, including asymptomatic cases, among each population. The relati...
Source: The Tohoku Journal of Experimental Medicine - May 27, 2020 Category: Research Authors: Sugishita Y, Kurita J, Sugawara T, Ohkusa Y Tags: Tohoku J Exp Med Source Type: research

Differences in the Magnitude of Motor Skill Acquisition and Interlimb Transfer between Left- and Right-Handed Subjects after Short-Term Unilateral Motor Skill Practice.
In conclusion, our results add to the body of literature by detecting the differences in the magnitude of motor skill acquisition and interlimb transfer between left- and right-handed subjects after short-term unilateral motor skill practice. PMID: 32434999 [PubMed - in process] (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - May 23, 2020 Category: Research Authors: Wang YF, Zhao J, Negyesi J, Nagatomi R Tags: Tohoku J Exp Med Source Type: research

Preceding Poor Physical Function Is Associated with New-Onset Musculoskeletal Pain among Older Natural Disaster Survivors: A Longitudinal Study after the Great East Japan Earthquake.
This study aimed to elucidate the association of poor physical function with new-onset musculoskeletal pain among older survivors after the Great East Japan Earthquake (GEJE). Survivors aged ≥ 65 years, 3 years after the GEJE, were assessed longitudinally for 1 year (n = 646). Musculoskeletal pain was assessed using a self-reported questionnaire, and new-onset musculoskeletal pain was defined as absence and presence of pain at 3 years and 4 years, respectively, after the disaster. Physical function at 3 years after the disaster was assessed using the Kihon Checklist physical function score, which consists of 5 yes/no qu...
Source: The Tohoku Journal of Experimental Medicine - May 23, 2020 Category: Research Authors: Yabe Y, Hagiwara Y, Sekiguchi T, Sugawara Y, Tsuchiya M, Yoshida S, Sogi Y, Yano T, Onoki T, Takahashi T, Iwatsu J, Tsuji I, Itoi E Tags: Tohoku J Exp Med Source Type: research

Subcutaneous Tocilizumab Is Effective for Treatment of Elderly-Onset Rheumatoid Arthritis.
Abstract Rheumatoid arthritis (RA) is an autoimmune disease characterized by systemic articular and bone manifestations and its pathogenesis is driven by a complex network of proinflammatory cytokines, including tumor necrosis factor and interleukin (IL)-6. Treatment of rheumatoid arthritis (RA) has been standardized by the introduction of a treat-to-target approach. Subcutaneous tocilizumab (TCZ-SC) is a humanized anti-IL-6 receptor monoclonal antibody, and is widely used for refractory RA patients in the clinical settings. However, it remains unknown whether TCZ-SC shows effectiveness for elderly onset RA. The s...
Source: The Tohoku Journal of Experimental Medicine - May 16, 2020 Category: Research Authors: Kondo N, Fujisawa J, Endo N Tags: Tohoku J Exp Med Source Type: research

Physician Distribution by Specialty and Practice Setting: Findings in Japan in 2000, 2010 and 2016.
Abstract As the medical demand is projected to increase along with the population aging in Japan, the geographical distribution of physicians is a significant concern for society and policymakers. To implement effective measures on geographical physician distribution, this study aimed to describe and compare the distribution of physicians by specialty in 2000, 2010 and 2016 in Japan, and examine whether practice setting was associated with distribution. To quantify the geographical physician distribution by specialty, we calculated the Gini coefficients of physicians working at clinics or hospitals in 2000, 2010, ...
Source: The Tohoku Journal of Experimental Medicine - May 9, 2020 Category: Research Authors: Ikesu R, Miyawaki A, Kobayashi Y Tags: Tohoku J Exp Med Source Type: research

Public Relations and Communication Strategies in Construction of Large-Scale Cohorts and Biobank: Practice in the Tohoku Medical Megabank Project.
Abstract The Tohoku Medical Megabank Project was designed as part of the national reconstruction project for addressing the damage from the 2011 Great East Japan Earthquake. It is an integrated project involving the genome cohort study of 150,000 participants, integrated biobank construction, and multi-omics analyses. Public relations and communication activities emerged to be extremely important in the successful development of this project. To gain insights into the contributions of these activities, we divided the public relations and communication activities for the project into three phases based on the situa...
Source: The Tohoku Journal of Experimental Medicine - April 25, 2020 Category: Research Authors: Nagami F, Kuriki M, Koreeda S, Kageyama M, Shimizu O, Toda S, Hozawa A, Kuriyama S, Osumi N, Yamamoto M Tags: Tohoku J Exp Med Source Type: research

Membrane Location of Syntaxin-Binding Protein 1 Is Correlated with Poor Prognosis of Lung Adenocarcinoma.
Abstract Lung cancer is the leading cause of cancer-related death, and adenocarcinoma is the most common histological type of lung cancer. Syntaxin-binding protein 1 (STXBP1) is essential for exocytosis of secretory vesicles. Since exocytosis is the basic cellular process of cells, we investigated STXBP1 expression and clinical significance in lung adenocarcinoma. We performed quantitative real-time polymerase chain reaction in 20 pairs of lung adenocarcinoma and paired normal tissues, and demonstrated that the relative expression levels of STXBP1 mRNA in lung adenocarcinoma was significantly higher than those in ...
Source: The Tohoku Journal of Experimental Medicine - April 25, 2020 Category: Research Authors: Wang X, Fu G, Wen J, Chen H, Zhang B, Zhu D Tags: Tohoku J Exp Med Source Type: research

The Coronavirus Disease 2019 (COVID-19) Pandemic.
Abstract The present study provides an overview of the coronavirus disease 2019 (COVID-19) outbreak which has rapidly extended globally within a short period. COVID-19 is a highly infectious respiratory disease caused by a new coronavirus known as SARS-CoV-2 (severe acute respiratory syndrome-coronavirus-2). SARS-CoV-2 is different from usual coronaviruses responsible for mild sickness such as common cold among human beings. It is crucial to understand the impact and outcome of this pandemic. We therefore overview the changes in the curves of COVID-19 confirmed cases and fatality rate in China and outside of China...
Source: The Tohoku Journal of Experimental Medicine - April 25, 2020 Category: Research Authors: Baloch S, Baloch MA, Zheng T, Pei X Tags: Tohoku J Exp Med Source Type: research

Neutrophil Gelatinase-Associated Lipocalin for Predicting Intensive Care Unit Admission and Mortality in Patients with Pneumonia.
Abstract Pneumonia is one of the most common causes of hospital admissions and mortality, and it is responsible for significant socioeconomic burden worldwide. Neutrophil gelatinase-associated lipocalin (NGAL) is a 25-kDa protein, which is involved in iron trafficking and has chemostatic and bacteriostatic effects. NGAL is also known as an early marker of many inflammatory diseases. However, little is known about the role of NGAL in the management of pneumonia. Thus, this study aimed to investigate whether plasma NGAL levels can predict intensive care unit (ICU) admission and in-hospital mortality in patients with...
Source: The Tohoku Journal of Experimental Medicine - April 22, 2020 Category: Research Authors: Min JH, Lee H, Chung SJ, Yeo Y, Park TS, Park DW, Moon JY, Kim SH, Kim TH, Sohn JW, Yoon HJ Tags: Tohoku J Exp Med Source Type: research

Cardiac Remodeling Biomarkers as Potential Circulating Markers of Left Ventricular Hypertrophy in Heart Failure with Preserved Ejection Fraction.
Abstract Soluble suppressor of tumorigenicity 2 (sST2), galectin-3, growth differentiation factor (GDF)-15 and syndecan-1 represent biomarkers of cardiac remodeling, involved in heart failure (HF) progression. We hypothesize that their plasma concentrations, together with brain natriuretic peptide (BNP), are different in HF stratified by ejection fraction (EF), demonstrating correlations with echocardiographic parameters that indicate left ventricular (LV) hypertrophy; LV mass index (LVMI) and posterior wall and septum diameters. HF patients (n = 77) were classified according to EF: reduced EF 50% (HFpEF). We foun...
Source: The Tohoku Journal of Experimental Medicine - April 17, 2020 Category: Research Authors: Mitic VT, Stojanovic DR, Deljanin Ilic MZ, Stojanovic MM, Petrovic DB, Ignjatovic AM, Stefanovic NZ, Kocic GM, Bojanic VV Tags: Tohoku J Exp Med Source Type: research

School Ijime (Bullying) Experience Is a Possible Risk Factor for Current Psychological Distress among Science City Workers: A Cross-Sectional Study in Tsukuba, Japan.
Abstract Early-life adversities are considered to have long-term impact on health. There have been many studies regarding the experience of being bullied and its harmful psychological influence, but such influence on workers remains to be investigated in Japan. We therefore aimed to examine the prevalence of workers with experiences of being bullied or bullying others during childhood and adolescence and to clarify the relation between those experiences and current psychological distress. A cross-sectional study using an anonymous self-report web questionnaire was conducted in November 2017. The study population w...
Source: The Tohoku Journal of Experimental Medicine - April 15, 2020 Category: Research Authors: Ikeda T, Hori D, Ikeda Y, Takahashi T, Shiraki N, Andrea CS, Ohtaki Y, Doki S, Oi Y, Sasahara S, Saito T, Matsuzaki I Tags: Tohoku J Exp Med Source Type: research

Veno-Venous Extracorporeal Membrane Oxygenation for Severe Pneumocystis jirovecii Pneumonia in an Immunocompromised Patient without HIV Infection.
Abstract Pneumocystis jirovecii pneumonia (PJP) occurs in immunocompromised hosts and is classified as PJP with human immunodeficiency virus (HIV) infection (HIV-PJP) and PJP without HIV infection (non-HIV PJP). Non-HIV PJP rapidly progresses to respiratory failure compared with HIV-PJP possibly due to the difference in immune conditions; namely, the prognosis of non-HIV PJP is worse than that of HIV PJP. However, the diagnosis of non-HIV PJP at the early stage is difficult. Herein, we report a case of severe non-HIV PJP successfully managed with veno-venous extracorporeal membrane oxygenation (V-V ECMO). A 54-yea...
Source: The Tohoku Journal of Experimental Medicine - April 7, 2020 Category: Research Authors: Nureki SI, Usagawa Y, Watanabe E, Takenaka R, Shigemitsu O, Abe T, Yasuda N, Goto K, Kitano T, Kadota JI Tags: Tohoku J Exp Med Source Type: research

Smoking during Pregnancy Is a Predictor of Poor Perinatal Outcomes in Maternal Anorexia Nervosa: A Case Series and Single-Center Cross-Sectional Study in Japan.
This study consists of a case series describing 13 single pregnancies of 11 women with a history of anorexia nervosa, and a cross-sectional study comparing 13 cases with 240 healthy controls. In the case group, nine cases conceived while underweight, including three who had fertility treatment. Anorexia symptoms during pregnancy were quite common, and pregnant smokers presented with extremely disturbed eating behaviors. In a cross-sectional study, premature birth and the standard deviations from the mean birth weight and mean head circumference at birth were evaluated as outcome measures. The adjusted odds ratios or the ad...
Source: The Tohoku Journal of Experimental Medicine - April 2, 2020 Category: Research Authors: Kasahara K, Ono T, Higuchi A, Katsura D, Hayashi K, Tokoro S, Tsuji S, Kimura F, Murakami T Tags: Tohoku J Exp Med Source Type: research

Reduction in the Number of Varicella-Zoster Virus-Specific T-Cells in Immunocompromised Children with Varicella.
In conclusion, the decreased numbers of VZV-specific CD8+T-cells during the acute phase and VZV-specific CD4+T-cells during the convalescent phase of disease may account for severe varicella in immunocompromised children. PMID: 32213753 [PubMed - in process] (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - March 28, 2020 Category: Research Authors: Murata K, Hoshina T, Onoyama S, Tanaka T, Kanno S, Ishimura M, Koga Y, Nakayama H, Ohga S Tags: Tohoku J Exp Med Source Type: research

Post-Traumatic West Syndrome due to Abusive Head Trauma in Two Infants with Different Brain Imaging Findings.
We describe two patients who developed West syndrome, which is a severe epilepsy syndrome composed of the triad of infantile spasms, hypsarrhythmia on electroencephalography, and developmental arrest or regression, possibly attributable to AHT. Case 1 was a 5-month-old boy presented with generalized convulsive status epilepticus when a babysitter had cared for him. Brain magnetic resonance imaging (MRI) exhibited a subdural hemorrhage with diffuse brain edema and a midline shift highly suggestive of AHT. He developed West syndrome at the age of 10 months. Case 2 was a 6-month-old girl presented infantile spasms and diagnos...
Source: The Tohoku Journal of Experimental Medicine - March 14, 2020 Category: Research Authors: Takeda R, Kobayashi S, Kamioka N, Hamajima N, Muramatsu K, Suzuki S Tags: Tohoku J Exp Med Source Type: research

Saline Solution Irrigation of the Bile Duct after Stone Removal Reduces the Recurrence of Common Bile Duct Stones.
This study included 477 patients (231 women; mean age, 80.5 years) who underwent EST and cleared CBD stones on cholangiography. A retrospective analysis was performed for the consecutively collected data. During the follow-up period of 6-75 months, the recurrence of CBD stones was observed in 99 patients (20.8%). The median time to the recurrence was 19.0 months (range 4-72 months). Multivariate analysis identified the need for mechanical lithotripsy, which was used for stone fragmentation, as a risk factor. Mechanical lithotripsy caused cholangiography-negative small residua. Notably, saline solution irrigation of the bil...
Source: The Tohoku Journal of Experimental Medicine - March 14, 2020 Category: Research Authors: Endo R, Satoh A, Tanaka Y, Shimoda F, Suzuki K, Takahashi K, Okata H, Hiramoto K, Kimura O, Asonuma S, Umemura K, Shimosegawa T Tags: Tohoku J Exp Med Source Type: research

Fetal Biparietal Diameter as a Potential Risk Factor for Emergency Cesarean Section due to Labor Arrest.
Abstract Labor arrest is the most common indication for emergency cesarean section (ECS). Increased biparietal diameter (BPD) has been reported as a risk factor for ECS due to labor arrest in different countries, but it is unclear whether this relationship is relevant in Japan. Considering the difference in maternal physique according to race and ethnicity, we retrospectively evaluated the association between ECS due to labor arrest and BPD, measured by ultrasonography
Source: The Tohoku Journal of Experimental Medicine - March 11, 2020 Category: Research Authors: Shinohara S, Amemiya A, Takizawa M Tags: Tohoku J Exp Med Source Type: research

Imaging Brain Mechanisms of Functional Somatic Syndromes: Potential as a Biomarker?
Abstract When patients present with persistent bodily complaints that cannot be explained by a symptom-linked organic pathology (medically unexplained symptoms), they are diagnosed with 'functional' somatic syndromes (FSS). Despite their prevalence, the management of FSS is notoriously challenging in clinical practice. This may be because FSS are heterogeneous disorders in terms of etiopathogenesis. They include patients with primarily peripheral dysfunction, primarily centrally driven somatic symptoms, and a mix of both. Brain-imaging studies, particularly data-driven pattern recognition methods using machine lea...
Source: The Tohoku Journal of Experimental Medicine - March 8, 2020 Category: Research Authors: Kano M, Oudenhove LV, Dupont P, Wager TD, Fukudo S Tags: Tohoku J Exp Med Source Type: research

Better Retention of Abatacept Is Associated with High Rheumatoid Factor: A Five-Year Follow-Up Study of Patients with Rheumatoid Arthritis.
In conclusion, ABT shows high retention rate among patients with positive RF. The present study may provide better insights when selecting bDMARDs. PMID: 32132324 [PubMed - in process] (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - March 8, 2020 Category: Research Authors: Okazaki S, Watanabe R, Harigae H, Fujii H Tags: Tohoku J Exp Med Source Type: research

Upper Extremity Pain Is Associated with Lower Back Pain among Young Basketball Players: A Cross-Sectional Study.
In conclusion, parents and coaches should be properly re-educated to help improve lower back, upper extremity, and shoulder pain among young basketball players. PMID: 32062615 [PubMed - in process] (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - February 19, 2020 Category: Research Authors: Hagiwara Y, Yabe Y, Sekiguchi T, Momma H, Tsuchiya M, Kanazawa K, Yoshida S, Sogi Y, Yano T, Onoki T, Itoi E, Nagatomi R Tags: Tohoku J Exp Med Source Type: research

Elevated Plasma Levels of Mitochondria-Derived Damage-Associated Molecular Patterns during Liver Transplantation: Predictors for Postoperative Multi-Organ Dysfunction Syndrome.
Abstract The systemic cytokine response during surgery has been reported to be stimulated by the molecules released from damaged cells, called damage-associated molecular patterns (DAMPs). The relationship between DAMPs and liver transplantation has not been reported. We aimed to clarify the relationship between the plasma levels of DAMPs and the short-term post-transplant outcomes, including mortality and postoperative multi-organ dysfunction syndrome (MODS). This retrospective cohort study enrolled 61 patients who underwent liver transplantation. Mitochondrial DNA fragments, as mitochondria-derived DAMPs (mtDAMP...
Source: The Tohoku Journal of Experimental Medicine - February 19, 2020 Category: Research Authors: Nagakawa K, Soyama A, Hidaka M, Adachi T, Ono S, Hara T, Takatsuki M, Eguchi S Tags: Tohoku J Exp Med Source Type: research

Absence of Relatives Impairs the Approach of Nurses to Cardiopulmonary Resuscitation in Non-Cancer Elderly Patients without a Do-Not-Attempt-Resuscitation Order: A Vignette-Based Questionnaire Study.
Abstract A Do-Not-Attempt-Resuscitation (DNAR) order solely precludes performing cardiopulmonary resuscitation (CPR) following cardiopulmonary arrest. A patient's personal status is known to influence a range of clinical practices, not only CPR, when a DNAR order is given. We assessed whether the absence of supporting relatives or a diagnosis of dementia can influence nurses' perceptions of clinical practices for elderly patients with non-malignant and chronic diseases. A vignette-based questionnaire was used to evaluate nurses' beliefs both before and after issuance of a DNAR order. Three vignettes were developed...
Source: The Tohoku Journal of Experimental Medicine - February 6, 2020 Category: Research Authors: Higuchi A, Takita M, Yoshii A, Akiyama T, Nemoto T, Nakahira R, Nakajima T, Fukahori H, Tsubokura M, Igarashi R Tags: Tohoku J Exp Med Source Type: research

Incremental Shuttle Walk Distance as an Indicator for Functional Exercise Capacity of Pre-Surgical Patients with Nontuberculous Mycobacterial Lung Disease.
Abstract The incidence of nontuberculous mycobacterial lung disease (NTMLD) is increasing worldwide, the number of lung surgeries is increasing accordingly. The disease is progressive and is characterized by exertional intolerance, respiratory dysfunctions, and impaired health-related quality of life (HRQOL). Treatment comprises multidrug antibiotic treatment combined with lung resection. The incremental shuttle walk distance (ISWD) is a standard tool for assessing the patients' tolerance to lung resection. The exertional tolerance, physical functions and HRQOL among pre-surgical patients with NTMLD are clinically...
Source: The Tohoku Journal of Experimental Medicine - January 31, 2020 Category: Research Authors: Kuroyama Y, Tabusadani M, Omatsu S, Shiraishi Y, Senjyu H Tags: Tohoku J Exp Med Source Type: research

Endometrial Immunity for Embryo Implantation and Pregnancy Establishment.
Abstract The uterus is an organ for raising the fetus, and its lumen is lined by the endometrium. The endometrium is an important site for the implantation and maturation of fertilized eggs. The endometrium undergoes repetitive proliferation, maturation (decidualization), and exfoliation changes every menstrual cycle. At the same time, the number and type of endometrial immunocompetent cells vary during the menstrual cycle. At the implantation stage, the immunocompetent cells occupy approximately half of the endometrial cells. Immunocompetent cells normally eliminate pathogenic microorganisms to protect the body; ...
Source: The Tohoku Journal of Experimental Medicine - January 31, 2020 Category: Research Authors: Kitazawa J, Kimura F, Nakamura A, Morimune A, Takahashi A, Takashima A, Amano T, Tsuji S, Kaku S, Kasahara K, Murakami T Tags: Tohoku J Exp Med Source Type: research

Preventive Effect of Tonsillectomy on Recurrence of Henoch-Sch ├Ânlein Purpura Nephritis after Intravenous Methylprednisolone Pulse Therapy.
Preventive Effect of Tonsillectomy on Recurrence of Henoch-Schönlein Purpura Nephritis after Intravenous Methylprednisolone Pulse Therapy. Tohoku J Exp Med. 2020;250(1):61-69 Authors: Umeda C, Fujinaga S, Endo A, Sakuraya K, Asanuma S, Hirano D Abstract Henoch-Schönlein purpura (HSP) is regarded as a benign and self-limiting vasculitis characterized by purpura, arthritis, and gastrointestinal symptoms; however, about one third of the patients develop HSP nephritis (HSPN), the most serious long-term complication. Since 2013, we have proposed that tonsillectomy in addition to intravenous methy...
Source: The Tohoku Journal of Experimental Medicine - January 31, 2020 Category: Research Authors: Umeda C, Fujinaga S, Endo A, Sakuraya K, Asanuma S, Hirano D Tags: Tohoku J Exp Med Source Type: research

A Message for Young Authors: The Past 100 Years and Future of the Tohoku Journal of Experimental Medicine.
Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - January 28, 2020 Category: Research Authors: The Past 100 Years and Future of the Tohoku Journal of Experimental Medicine. Tags: Tohoku J Exp Med Source Type: research

Efficacy and Safety of Targeted Strategy for Treating Rheumatoid Arthritis Patients Aged 75 Years or Older.
Abstract The efficacy and safety of targeted treatment for elderly patients with rheumatoid arthritis (RA) was considered. Patients with RA who met the ACR/EULAR 2010 classification criteria and were treated consecutively for> 3 years, were recruited and classified into three age groups with 10-year increments from 65 years. Treatment protocol that aims to achieve clinical remission within 6 months was commonly adopted. The salient features are the rapid increase in dosages of conventional synthetic anti-rheumatic drugs (csDMARDs) and the administration of need-based concomitant biologic/targeted synthetic drug...
Source: The Tohoku Journal of Experimental Medicine - January 24, 2020 Category: Research Authors: Yoshii I, Chijiwa T, Sawada N Tags: Tohoku J Exp Med Source Type: research

A Nationwide Survey of Obstetric Care Status on Japan's Islands, with Special Reference to Maternal Transport to the Mainland.
Abstract Safe obstetric care is a worldwide requirement. In Japan, a reduced number of obstetricians has prompted the centralization of obstetric facilities, and Japan's islands are expected to experience problems in handling deliveries. Although many pregnant women "move" to the mainland at later gestational weeks, "transport" from the island to the mainland may be occasionally needed when disorders manifest before the "move." Other women plan within-island deliveries; however, transport is required when complications arise. Managing delivery- or pregnancy-related problems may differ...
Source: The Tohoku Journal of Experimental Medicine - January 24, 2020 Category: Research Authors: Sumikawa S, Kotani K, Kojo T, Matsubara S, Haruyama S Tags: Tohoku J Exp Med Source Type: research

The Risk of Developing Multiple Primary Cancers among Long-Term Survivors Five Years or More after Stomach Carcinoma Resection.
We examined the prognostic differences in 527 patients with MPC according to the diagnosis time. In 325 patients of long-term survivors in whom MPC was diagnosed ≥ 5 years postoperative, 5-year survival rate and the median survival time after diagnosis were 35.1% and 17.7 months, respectively. This outcome was significantly poorer than that of 160 patients in whom MPC was diagnosed within 5 years postoperative (58.5% and 62.7 months, P
Source: The Tohoku Journal of Experimental Medicine - January 24, 2020 Category: Research Authors: Amikura K, Ehara K, Kawashima Y Tags: Tohoku J Exp Med Source Type: research

An Early-Onset Neuronopathic Form of Acid Sphingomyelinase Deficiency: A SMPD1 p.C133Y Mutation in the Saposin Domain of Acid Sphingomyelinase.
Abstract Acid sphingomyelinase (ASM) is a lysosomal hydrolase that degrades sphingomyelin into ceramide and phosphocholine. Recent crystallographic studies revealed the functional role of the N-terminal ASM saposin domain. ASM deficiency due to mutations in the ASM-encoding sphingomyelin phosphodiesterase 1 (SMPD1) gene causes an autosomal recessive sphingolipid-storage disorder, known as Niemann-Pick disease Type A (NPA) or Type B (NPB). NPA is an early-onset neuronopathic disorder, while NPB is a late-onset non-neuronopathic disorder. A homozygous one-base substitution (c.398G>A) of the SMPD1 gene was identif...
Source: The Tohoku Journal of Experimental Medicine - January 17, 2020 Category: Research Authors: Ota S, Noguchi A, Kondo D, Nakajima Y, Ito T, Arai H, Takahashi T Tags: Tohoku J Exp Med Source Type: research

Difference in the Types of Treated Cancer between Clinics and Small-to-Middle-Sized Hospitals in Rural Communities of Japan.
This study investigated the types treated at the institutions in rural communities of Japan. A questionnaire survey was conducted for 811 public rural institutions (clinics and small-to-middle-sized hospitals [
Source: The Tohoku Journal of Experimental Medicine - December 27, 2019 Category: Research Authors: Komatsu K, Teraura H, Yamaguchi H, Kotani K Tags: Tohoku J Exp Med Source Type: research

Adenosine Attenuates Aortic Smooth Muscle Cell Calcification through A3 Adenosine Receptor.
In this study, we investigated the inhibitory effects of adenosine on vascular calcification in vitro by utilizing the culture of human aortic smooth muscle cells (HASMCs). Osteoblastic differentiation of HASMCs was induced by the treatment with oncostatin M and osteogenic differentiation medium. Adenosine and its metabolically stable analogue, 2-chloroadenosine (CADO) significantly reduced matrix mineralization and alkaline phosphatase (ALP) activities in HASMCs. The mRNA expression of tissue non-specific alkaline phosphatase (TNAP) was down-regulated by adenosine and CADO, but the mRNA expression of other osteoblastic di...
Source: The Tohoku Journal of Experimental Medicine - December 27, 2019 Category: Research Authors: Fujimoto K, Shioi A, Miki Y, Kakutani Y, Morioka T, Shoji T, Emoto M, Inaba M Tags: Tohoku J Exp Med Source Type: research

Malignancies in Patients with IgG4-Related Diseases in Head and Neck Regions.
Abstract Immunoglobulin G4-related disease (IgG4-RD) is a recently recognized disease, characterized by high serum IgG4 concentrations and IgG4-producing plasma cell expansion with fibrotic or sclerotic changes in affected organs. Recent work has focused on the relationship between IgG4-RD and malignancies, but there is no report of malignancies associated with IgG4-RD in head and neck regions. The aim of this study was to analyze the clinicopathological characteristics of malignancies in patients with IgG4-RD in head and neck regions. We retrospectively analyzed 26 patients with IgG4-RD (12 men and 14 women aged ...
Source: The Tohoku Journal of Experimental Medicine - December 27, 2019 Category: Research Authors: Ikeda R, Kurakami K, Ohta N, Suzuki T, Saito Y, Kusano Y, Yamazaki M, Tateda Y, Kitaya S, Kakehata S, Takahashi H, Satoh K Tags: Tohoku J Exp Med Source Type: research

Esophageal Carcinosarcoma with Basaloid Squamous Cell Carcinoma: A Case Report and Review of the Literature.
We report a case of esophageal carcinosarcoma harboring basaloid squamous cell carcinoma successfully treated with preoperative chemotherapy. A 78-year-old man complaining dysphagia was diagnosed as esophageal carcinosarcoma. After two courses of preoperative chemotherapy with cisplatin and 5-fluorouracil, curative esophagectomy with lymph node dissection was performed thoracoscopically. Histopathological findings of the resected specimen revealed the mixture of basaloid squamous cell carcinoma and sarcomatous spindle cells. A transitional zone between both components was also detected. As fibrosis was identified around bo...
Source: The Tohoku Journal of Experimental Medicine - December 21, 2019 Category: Research Authors: Ishida H, Fujishima F, Onodera Y, Konno-Kumagai T, Maruyama S, Okamoto H, Sato C, Heishi T, Sakurai T, Taniyama Y, Kamei T, Sasano H Tags: Tohoku J Exp Med Source Type: research

Determinants of Vaccination Coverage for the Second Dose of Measles-Rubella Vaccine in Tokyo, Japan.
In conclusion, the health authorities can exert efforts to reduce burden of time spent for vaccination and provide sufficient information to improve coverage. PMID: 31852852 [PubMed - in process] (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - December 21, 2019 Category: Research Authors: Sugishita Y, Kurita J, Akagi T, Sugawara T, Ohkusa Y Tags: Tohoku J Exp Med Source Type: research

GPI-80 as a Useful Index for Myeloid Cell Heterogeneity and a Potential Prognostic Biomarker for Metastatic Renal Cell Carcinoma.
In conclusion, the expression of GPI-80 on myeloid cells, a useful index for the heterogeneity of MDSCs, serves as a potential prognostic biomarker for mRCC. PMID: 31776298 [PubMed - in process] (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - November 30, 2019 Category: Research Authors: Kato T, Takeda Y, Ito H, Kurota Y, Yamagishi A, Sakurai T, Naito S, Araki A, Nara H, Asao H, Tsuchiya N Tags: Tohoku J Exp Med Source Type: research

Expression Profiling of Exosomal miRNAs Derived from the Aqueous Humor of Myopia Patients.
In conclusion, we show the expression profiles of AH-derived exosomal miRNAs and their potential roles in myopia development. PMID: 31776299 [PubMed - in process] (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - November 30, 2019 Category: Research Authors: Chen CF, Hua K, Woung LC, Lin CH, Chen CT, Hsu CH, Liou SW, Tsai CY Tags: Tohoku J Exp Med Source Type: research

The Presence of Thyroid Peroxidase Antibody Is Associated with Lower Placental Weight in Maternal Thyroid Dysfunction.
Abstract Thyroid dysfunction (TD) is caused by thyroid peroxidase (TPO) antibody, as seen in Hashimoto's disease. TD is a common problem of reproductive age and may impair fetal development. Here, we determined the effect of TPO antibody on perinatal outcomes in Japanese women with TD before conception. A retrospective study involving cases of maternal TD with term singleton birth was conducted. The subjects with TD were divided into two groups according to the presence (n = 22) or absence (n = 20) of TPO antibody. The control groups matched for age, parity, and gestational weeks were selected for TPO antibody-pos...
Source: The Tohoku Journal of Experimental Medicine - November 30, 2019 Category: Research Authors: Ushijima J, Furukawa S, Sameshima H Tags: Tohoku J Exp Med Source Type: research

Laparoscopic Sleeve Gastrectomy on Severe Obesity after Intracranial Germinoma Treatment: A Case Report.
Abstract Hypothalamic obesity is a clinical syndrome characterized by severe and refractory obesity that is caused by hypothalamic function impairment. Recently, bariatric surgery has been attempted for patients with hypothalamic obesity after craniopharyngioma, but experiences have not yet been accumulated in other hypothalamic disorders. Here, we report the case of a 39-year-old male patient with panhypopituitarism who received laparoscopic sleeve gastrectomy (LSG) after intracranial germinoma treatment. The patient was diagnosed with intracranial germinoma at age 15 and achieved complete remission after radioth...
Source: The Tohoku Journal of Experimental Medicine - November 30, 2019 Category: Research Authors: Nezu M, Kudo M, Ono Y, Tezuka Y, Morimoto R, Sawada S, Imoto H, Naitoh T, Katagiri H, Ito S, Satoh F Tags: Tohoku J Exp Med Source Type: research