Non-Regular Employment Status Is Associated with Psychological Distress among Young Researchers: A Cross-Sectional Study in Tsukuba, Japan.
Abstract Non-regular employment is increasing and its mental health impact is a globally important problem. In Japan, non-regularly employed researchers are increasing, especially within young age groups, because employment quotas were not sufficiently expanded against rapid increasing number of doctorate holders. It is therefore important to understand the relationship between non-regular employment and mental health. The significance of our research is to contribute to the improvement of researchers' mental health by clarifying the influence of employment status on psychological distress. We conducted a cross-se...
Source: The Tohoku Journal of Experimental Medicine - October 2, 2019 Category: Research Authors: Takahashi T, Hori D, Ikeda T, Ikeda Y, Shiraki N, Andrea CS, Ohtaki Y, Doki S, Oi Y, Sasahara S, Matsuzaki I Tags: Tohoku J Exp Med Source Type: research

High Hematocrit Levels Are Associated with Risk of Cardiovascular Mortality among Middle-Aged Japanese Women: The Ibaraki Prefectural Health Study (IPHS).
This study is the first one to demonstrate an association between high hematocrit level and risk of AMI mortality in younger Japanese women, but not in men and older women. PMID: 31564685 [PubMed - in process] (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - October 2, 2019 Category: Research Authors: Takaoka N, Sairenchi T, Irie F, Matsushita M, Nagao M, Umesawa M, Haruyama Y, Watanabe H, Yamagishi K, Iso H, Kobashi G, Ota H Tags: Tohoku J Exp Med Source Type: research

Professional Oral Care Reduces Carcinogenic Acetaldehyde Levels in Mouth Air of Perioperative Esophageal Cancer Patients: A Prospective Comparative Study.
In conclusion, professional oral care for esophageal cancer patients is effective for reducing acetaldehyde levels in mouth air due to the reduction of microbial count. PMID: 31564686 [PubMed - in process] (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - October 2, 2019 Category: Research Authors: Tanda N, Washio J, Kamei T, Akazawa K, Takahashi N, Koseki T Tags: Tohoku J Exp Med Source Type: research

Rapidly Progressive Nephronophthisis in a 2-Year-Old Boy with a Homozygous SDCCAG8 Mutation.
Abstract Nephronophthisis (NPHP) is an autosomal recessive cystic kidney disease that is characterized by primary ciliary dysfunction (ciliopathy) and progresses to end-stage kidney disease (ESKD) during the second decade of life (juvenile and adolescent NPHP) or before the age of 3 years (infantile NPHP). Here we describe the case of an infant with NPHP who carries a homozygous mutation in SDCCAG8 (also called NPHP10 or BBS16) that encodes SDCCAG8 (serologically defined colon cancer antigen 8). SDCCAG8 is localized at the centrioles of both renal epithelial cells and retinal photoreceptor cells. A mutation in SDC...
Source: The Tohoku Journal of Experimental Medicine - September 21, 2019 Category: Research Authors: Watanabe Y, Fujinaga S, Sakuraya K, Morisada N, Nozu K, Iijima K Tags: Tohoku J Exp Med Source Type: research

Flow Cytometry-Based Photodynamic Diagnosis with 5-Aminolevulinic Acid for the Detection of Minimal Residual Disease in Multiple Myeloma.
Abstract Multiple myeloma is the cancer of plasma cells. Along with the development of new and effective therapies, improved outcomes in patients with multiple myeloma have increased the interest in minimal residual disease (MRD) monitoring. However, the considerable heterogeneity of immunophenotypic and molecular markers of myeloma cells has limited its clinical application. 5-Aminolevulinic acid (ALA) is a natural compound in the heme biosynthesis pathway. Following ALA treatment, tumor cells preferentially accumulate porphyrins because of the differential activities of aerobic glycolysis, known as Warburg effec...
Source: The Tohoku Journal of Experimental Medicine - September 14, 2019 Category: Research Authors: Iwaki K, Fujiwara T, Ito T, Suzuki C, Sasaki K, Ono K, Saito K, Fukuhara N, Onishi Y, Yokoyama H, Fujimaki S, Tanaka T, Tamura H, Fujiwara M, Harigae H Tags: Tohoku J Exp Med Source Type: research

Developing a Prenatal Couple Education Program Focusing on Coparenting for Japanese Couples: A Quasi-Experimental Study.
Abstract Having and raising children can be a source of joy for parents. However, the transition to parenthood is associated with a certain degree of strain and stress, and couple relationship quality often declines during the transition. Coparenting, the shared responsibility of childrearing, benefits both parents and children and is an important aspect of the transition to parenthood. In this quasi-experimental study, we aimed to develop a couple education program in Japan that focuses on coparenting among couples expecting their first child. Twenty-one healthy couples voluntarily participated in the interventio...
Source: The Tohoku Journal of Experimental Medicine - September 14, 2019 Category: Research Authors: Takeishi Y, Nakamura Y, Kawajiri M, Atogami F, Yoshizawa T Tags: Tohoku J Exp Med Source Type: research

Plasma Free Protein S Is Correlated with Disease Activity, but not with Subclinical Atherosclerosis among Patients with Systemic Lupus Erythematosus: A Cross-Sectional Study.
Abstract A defect in clearance of apoptotic materials is pivotal in the pathogenesis of systemic lupus erythematosus (SLE). Protein S participates in the removal of apoptotic remnants and the anticoagulation pathway. The aim of the study was to clarify the relationship between plasma levels of free protein S and the disease activity or subclinical atherosclerosis in SLE. Free protein S was measured by an enzyme-linked immunosorbent assay, and patients were classified into two groups of free protein S levels: low ( 4.6 mm) or with carotid artery plaque between two groups. The low levels of free protein S were assoc...
Source: The Tohoku Journal of Experimental Medicine - September 14, 2019 Category: Research Authors: Jung JY, Lee SW, Kim HA, Suh CH Tags: Tohoku J Exp Med Source Type: research

Anemia and Low Albumin Levels Are Associated with Severe Community-Acquired Pneumonia in Pregnancy: A Case-Control Study.
This study aimed to analyze the clinical characteristics and factors associated with SCAP in pregnancy. The present study was a case-control study of pregnant women hospitalized between September 2012 and September 2017 at nine tertiary hospitals in China. Among 358,424 pregnant women, we found 35 SCAP cases and 393 common CAP cases. The 35 SCAP cases were matched 1:4 with common CAP cases (n = 140), based on patient age and gestational weeks. Infection indicators, hemoglobin, platelets, coagulation function, liver, and kidney function markers, myocardial enzyme, arterial oxygen pressure/fraction inspired oxygen (PO2/FiO2)...
Source: The Tohoku Journal of Experimental Medicine - August 30, 2019 Category: Research Authors: He Y, Li M, Mai C, Chen L, Zhang X, Zhou J, Yang Z, Ni J, Chen Y, Cai M, Qi Q, Yang Z Tags: Tohoku J Exp Med Source Type: research

Fetal Sinus Bradycardia Is Associated with Congenital Hypothyroidism: An Infant with Ectopic Thyroid Tissue.
In conclusion, congenital hypothyroidism should be included in the differential diagnosis in cases of fetal bradycardia without cardiac anomalies or maternal autoimmune diseases. PMID: 31462599 [PubMed - in process] (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - August 30, 2019 Category: Research Authors: Nakanomori A, Nagano N, Seimiya A, Okahashi A, Morioka I Tags: Tohoku J Exp Med Source Type: research

Unreliable Information as a Risk Factor for Worse Mental Fatigue among Residents in Fukushima after the Nuclear Power Station Accident.
Abstract After the Fukushima nuclear accident in 2011, there was confusion among the public caused by uncoordinated information about radiation provided by diverse channels. We explored the association between information sources regarding reconstruction progress after the disaster and mental fatigue in Fukushima. We used data from the annual public opinion survey by the Fukushima Prefectural Government on its policies from 2013 to 2015, which contained survey responses from 1,300 community residents randomly selected from the 28 municipalities in the Fukushima Prefecture. The survey contained a question assessing...
Source: The Tohoku Journal of Experimental Medicine - August 23, 2019 Category: Research Authors: Yumiya Y, Murakami M, Takebayashi Y, Suzuki S, Ohira T Tags: Tohoku J Exp Med Source Type: research

A Medical Record Peer-Review System to Evaluate Residents' Clinical Competence: Criterion Validity Analysis.
Abstract In contrast to input evaluation (education delivered at school) and output evaluation (students' capability at graduation), the methods of outcome evaluation (performance after graduation) of medical education have not been sufficiently established. To establish a method to measure the quality of patient care and conduct outcome evaluation, we have been developing a peer review system of medical records. Here, we undertook a pilot study to evaluate the criterion validity of our system by using "evaluation by program directors (supervisors in the hospitals)" as a criterion standard. We selected 1...
Source: The Tohoku Journal of Experimental Medicine - August 23, 2019 Category: Research Authors: Kameoka J, Kikukawa M, Kobayashi D, Okubo T, Ishii S, Kagaya Y Tags: Tohoku J Exp Med Source Type: research

Risk Factors for Problem Drinking among Evacuees in Fukushima following the Great East Japan Earthquake: The Fukushima Health Management Survey.
In this study, we therefore aimed to explore the risk factors associated with the incidence of problem drinking among evacuees after the Great East Japan Earthquake of March 11, 2011. We used the data for evacuees of the Fukushima Daiichi nuclear power plant accident, obtained from the Mental Health and Lifestyle Survey. A total of 12,490 individuals from 13 municipalities, which included the evacuation order areas after the accident, completed surveys between 2012 and 2013. The CAGE (Cutting down, Annoyed by criticism, Guilty feeling, and Eye-opener) questionnaire was used to screen the participants for alcohol dependence...
Source: The Tohoku Journal of Experimental Medicine - August 15, 2019 Category: Research Authors: Ueda Y, Murakami M, Maeda M, Yabe H, Suzuki Y, Orui M, Yasumura S, Ohira T, Fukushima Health Management Survey Group Tags: Tohoku J Exp Med Source Type: research

A New Insight into Chronic Pancreatitis.
Abstract Chronic pancreatitis (CP) is a pancreatic disease with poor prognosis characterized clinically by abdominal pain, morphologically by pancreatic stones/calcification, duct dilatation and atrophy, and functionally by pancreatic exocrine and endocrine insufficiency. CP is also known as a risk factor for the development of pancreatic cancer. CP has long been understood based on a fixed disease concept deduced from the clinical and morphological features of the end-stage disease. However, identification of causal genes for hereditary pancreatitis and success in the isolation and culture of pancreatic stellate ...
Source: The Tohoku Journal of Experimental Medicine - August 6, 2019 Category: Research Authors: Shimosegawa T Tags: Tohoku J Exp Med Source Type: research

Adverse Effects of Wi-Fi Radiation on Male Reproductive System: A Systematic Review.
In conclusion, exposure towards 2.45 GHz RF-EMR emitted by Wi-Fi transmitter is hazardous on the male reproductive system. PMID: 31353326 [PubMed - in process] (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - July 30, 2019 Category: Research Authors: Jaffar FHF, Osman K, Ismail NH, Chin KY, Ibrahim SF Tags: Tohoku J Exp Med Source Type: research

Association between Beta3-Adrenergic Receptor Trp64Arg Polymorphism and Fat Preference in Healthy Young Japanese Women.
Abstract Beta3-adrenergic receptor (ADRB3) is a mediator of catecholamine-stimulated lipolysis in humans. The Trp64Arg polymorphism with T/C transition in the ADRB3 gene has been considered to reduce lipolysis and metabolic expenditure. Here, we investigated the hitherto unknown role of the Trp64Arg substitution on food preference among healthy young adults (mean age, 24.3; n = 53, including 25 men). Preference toward four food types (bitter, sour, salty, or sweet) and greasy (high-fat) foods was examined using a self-reported questionnaire. There was no noticeable sex-difference in food preference. Incidentally, ...
Source: The Tohoku Journal of Experimental Medicine - July 30, 2019 Category: Research Authors: Watanabe K, Hong G, Tominami K, Izumi S, Hayashi Y, Kudo TA Tags: Tohoku J Exp Med Source Type: research

Idiopathic Short Stature Phenotypes among Korean Children: Cluster Analysis.
This study offers a new multidimensional approach to enable personalized growth hormone treatment optimization according to ISS phenotypes. PMID: 31353328 [PubMed - in process] (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - July 30, 2019 Category: Research Authors: Nam HK, Kim HR, Lee KH, Rhie YJ Tags: Tohoku J Exp Med Source Type: research

Historical, Current and Future Approaches to Surgery for Rhegmatogenous Retinal Detachment.
Abstract Rhegmatogenous retinal detachment (RRD) is a serious condition that can cause blindness without surgical treatment. RRD occurs when a retinal tear or hole allows fluid to accumulate below the retinal surface, causing the retina to separate from the underlying layers. RRD is difficult to treat because each case is unique, varying with the location, size, and duration of the detachment, as well as patient age. The first successful methods to reattach the retina in RRD used thermocautery to repair the detachment. Many renowned ophthalmologists continued to study RRD and developed many new surgical approaches...
Source: The Tohoku Journal of Experimental Medicine - July 17, 2019 Category: Research Authors: Kunikata H, Abe T, Nakazawa T Tags: Tohoku J Exp Med Source Type: research

Role Modeling for Female Surgeons in Japan.
This article describes our philosophy and activities, and our concept of role modeling. To find a single perfect role model is impossible in Japan, because lifestyle and family situations are quite different among individuals. Many young doctors in Japan find difficulties in identifying role models appropriate to their own situations. Our concept of remote role modeling is to identify multiple outstanding persons with excellent roles that one wishes to emulate; classify them by field of work, lifestyle, family situations, and others; then select the parts that one needs and assemble them to customize one's own ideal role m...
Source: The Tohoku Journal of Experimental Medicine - July 6, 2019 Category: Research Authors: Tomizawa Y Tags: Tohoku J Exp Med Source Type: research

Indium Lung: Discovery, Pathophysiology and Prevention.
Abstract Indium is mainly used as indium-tin oxide (ITO), which has a unique character of transparency, and is a requisite in making liquid crystal displays. Pulmonary toxicity of indium compounds in humans were not recognized until the last 2 decades. Several initial human cases of indium-related lung disease, named indium lung, were reported in Japan, with their main pathologic findings being interstitial pneumonia, emphysema and cholesterol crystals-containing granulomas. In 2010, three cases with alveolar proteinosis were reported from the United States and China. As of March 2019, more than 10 cases of inters...
Source: The Tohoku Journal of Experimental Medicine - July 3, 2019 Category: Research Authors: Chonan T, Amata A, Kawabata Y, Omae K Tags: Tohoku J Exp Med Source Type: research

Asthma Exacerbation Coincident with Saddle Pulmonary Embolism and Paradoxical Embolism.
Abstract Saddle pulmonary embolism (PE) and paradoxical embolism (PDE) are life-threatening disorders carrying a risk of sudden death, and their prompt diagnosis is extremely important. Saddle PE is a radiologic definition and refers to a thrombus that straddles the bifurcation of the pulmonary artery trunk, carrying a risk of sudden hemodynamic collapse. PDE is defined as a systemic arterial embolus due to the passage of a venous thrombus though a right-to-left shunt, such as patent foramen ovale (PFO). We herein present the rare case of asthma exacerbation coincident with saddle PE and PDE. A 69-year-old woman w...
Source: The Tohoku Journal of Experimental Medicine - June 29, 2019 Category: Research Authors: Hashimoto T, Ando M, Kan T, Fujishima N, Yamasue M, Komiya K, Umeki K, Nureki SI, Kadota JI Tags: Tohoku J Exp Med Source Type: research

Hyaluronan as a Promising Biomarker for Myocardial Damage.
Abstract Hyaluronan is a glycosaminoglycan, one of the chief components of the extracellular matrix. The aim of the present study is to investigate plasma hyaluronan levels among patients with acute myocardial infarction (AMI). This prospective study enrolled 56 consecutive patients with AMI who underwent percutaneous coronary intervention within 2 hours after admission. Plasma levels of hyaluronan were measured at the time of admission (baseline), and on the 7th and 30th day after AMI. Echocardiographic examinations were performed at baseline and on the 30th day after AMI. The hyaluronan levels were 33.2 ±...
Source: The Tohoku Journal of Experimental Medicine - June 29, 2019 Category: Research Authors: Savas G, Kalay N, Altin P, Dursun GK, Cetin M, Aytekin M Tags: Tohoku J Exp Med Source Type: research

Worsening Health Status among Evacuees: Analysis of Medical Expenditures after the 2011 Great East Japan Earthquake and Nuclear Disaster in Fukushima.
Abstract After Fukushima disaster in 2011, the health status of the region's residents deteriorated. We analyzed the health status, care needs, and access to health services among evacuees and non-evacuees using healthcare expenditure (for self-employed and unemployed individuals aged
Source: The Tohoku Journal of Experimental Medicine - June 29, 2019 Category: Research Authors: Hasegawa M, Murakami M, Nomura S, Takebayashi Y, Tsubokura M Tags: Tohoku J Exp Med Source Type: research

Risk-Stratified Incidence of Renal Replacement Therapy Initiation: A Longitudinal Analysis Using Medical Claims and Health Checkup Data.
Abstract Intervention for higher-risk participants of health checkups especially with diabetes has been started in Japan to prevent renal replacement therapy (RRT) initiation, but evidence about RRT initiation risk among checkup participants has been scarce. To estimate the incidence by risk factors, we conducted a retrospective cohort study using medical claims and checkup data of a community-based insurance scheme in Japan. Beneficiaries who participated in the checkup in 2012-2013 were included and followed up for about five years. We estimated the incidence of RRT initiation by the subject characteristics, fol...
Source: The Tohoku Journal of Experimental Medicine - June 29, 2019 Category: Research Authors: Sugiyama T, Oba K, Kobayashi Y Tags: Tohoku J Exp Med Source Type: research

Verbal Abuse from Coaches Is Associated with Loss of Motivation for the Present Sport in Young Athletes: A Cross-Sectional Study in Miyagi Prefecture.
Abstract Verbal and physical abuse from coaches has negative effects on young athletes. Although the abuse can lead to the athletes' dropping out, no studies have reported on this topic. The purpose of this study was to elucidate the association between experience of verbal or physical abuse from coaches and loss of motivation for the present sport in young athletes. School-aged athletes (age range, 6-15 years, n = 6,791) were assessed using a self-reported questionnaire. Multivariate logistic regression models were used to assess the association between experience of verbal or physical abuse and loss of motivatio...
Source: The Tohoku Journal of Experimental Medicine - June 26, 2019 Category: Research Authors: Yabe Y, Hagiwara Y, Sekiguchi T, Momma H, Tsuchiya M, Kuroki K, Kanazawa K, Koide M, Itaya N, Yoshida S, Sogi Y, Yano T, Itoi E, Nagatomi R Tags: Tohoku J Exp Med Source Type: research

Expression Profiling of Receptor-Activator of Nuclear Factor-Kappa B Ligand in Soft Tissue Tumors.
In conclusion, RANKL is expressed in subsets of soft tissue tumors with calcification, and denosumab is a potential therapeutic option for soft tissue tumors expressing RANKL. PMID: 31189751 [PubMed - in process] (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - June 14, 2019 Category: Research Authors: Yamagishi T, Kawashima H, Ogose A, Ariizumi T, Oike N, Sasaki T, Hatano H, Ohashi R, Umezu H, Ajioka Y, Endo N Tags: Tohoku J Exp Med Source Type: research

Elevated Serum Ferritin Levels Are Predictive of Renal Function Recovery among Patients with Acute Kidney Injury.
Abstract Oxidative stress (OS) frequently contributes to the development of acute kidney injury (AKI). Iron can promote oxidative stress and tissue injury by catalyzing free reactive oxygen species (ROS) generation and increasing the steady-state concentration of these potent oxidants. The anticipated role of ferritin is to protect from OS by sequestering iron and limiting its involvement in reactions that generate ROS. In this prospective study, we aimed to investigate the association between serum ferritin levels and kidney function recovery among patients with AKI. Renal recovery was determined as a return of s...
Source: The Tohoku Journal of Experimental Medicine - June 12, 2019 Category: Research Authors: Dimitrijevic ZM, Salinger-Martinovic SS, Jankovic RJ, Mitic BP Tags: Tohoku J Exp Med Source Type: research

Medical Needs in Minamisanriku Town after the Great East Japan Earthquake.
Abstract The medical records of service in disaster provided at a place other than a medical facility are defined as disaster medical records (DMRs). In this epidemiological study, to clarify medical need characteristics and trends after disaster, we analyzed the all anonymized DMRs of Minamisanriku Town that lost medical facilities in 2011 Great East Japan Earthquake and its consequent tsunami. After screening of duplicated or irrelevant documents, there were 10,464 DMRs with 18,532 diagnoses from March 11 through May 13. From 34 diagnostic groups according to International Classification of Diseases (ICD)-10, we...
Source: The Tohoku Journal of Experimental Medicine - June 12, 2019 Category: Research Authors: Suda T, Murakami A, Nakamura Y, Sasaki H, Tsuji I, Sugawara Y, Hatsugai K, Nishizawa M, Egawa S Tags: Tohoku J Exp Med Source Type: research

Intrahepatic Cholestasis of Pregnancy as a Clinical Manifestation of Sodium-Taurocholate Cotransporting Polypeptide Deficiency.
In conclusion, we suggest that with hypercholanemia being a common laboratory change, NTCP deficiency may be a genetic factor leading to ICP and even cesarean section in clinical practice. PMID: 31142693 [PubMed - in process] (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - June 2, 2019 Category: Research Authors: Chen R, Deng M, Rauf YM, Lin GZ, Qiu JW, Zhu SY, Xiao XM, Song YZ Tags: Tohoku J Exp Med Source Type: research

Biobank Establishment and Sample Management in the Tohoku Medical Megabank Project.
Abstract The Tohoku Medical Megabank biobank (TMM biobank) is the first major population-based biobank established in Japan. The TMM biobank was established based on two population cohorts and is a reconstruction program from the Great East Japan Earthquake and Tsunami of 2011. The biobank stores more than 3.4 million tubes of biospecimens and associated health and analytic data obtained from approximately 150,000 TMM cohort participants between May 2013 and December 2018, and the TMM biobank currently shares high-quality specimens and data. Various biospecimens, including peripheral and cord blood mononuclear cel...
Source: The Tohoku Journal of Experimental Medicine - May 30, 2019 Category: Research Authors: Minegishi N, Nishijima I, Nobukuni T, Kudo H, Ishida N, Terakawa T, Kumada K, Yamashita R, Katsuoka F, Ogishima S, Suzuki K, Sasaki M, Satoh M, Tohoku Medical Megabank Project Study Group, Yamamoto M Tags: Tohoku J Exp Med Source Type: research

100 Years of the Tohoku Journal of Experimental Medicine, and the Tohoku Medical Megabank Project in the Japanese New Era, Reiwa.
PMID: 31118358 [PubMed - in process] (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - May 24, 2019 Category: Research Authors: Takahashi K, Shibahara S Tags: Tohoku J Exp Med Source Type: research

Improvement of Cardiac Function by Laparoscopic Adrenalectomy in a Patient with Severe Heart Failure Attributable to Primary Aldosteronism.
Abstract Aldosterone affects various systems and organs, including the cardiovascular system, through mineralocorticoid receptors. We here report a primary aldosteronism patient with severe cardiac dysfunction who showed dramatic improvement after laparoscopic adrenalectomy. The 57-year-old man presented with acute heart failure exacerbation. Performance status was 4, and New York Heart Association classification was 4. Echocardiography showed diffuse hypokinetic wall motion with an ejection fraction of 20%. The patient was found to have a high plasma level of brain natriuretic peptide (4,935 pg/mL), hypokalemia (...
Source: The Tohoku Journal of Experimental Medicine - May 18, 2019 Category: Research Authors: Sato S, Kawasaki Y, Ito A, Morimoto R, Shimada S, Sato T, Izumi H, Kawamorita N, Yamashita S, Mitsuzuka K, Arai Y Tags: Tohoku J Exp Med Source Type: research

Fraxetin Suppresses Proliferation of Non-Small-Cell Lung Cancer Cells via Preventing Activation of Signal Transducer and Activator of Transcription 3.
In conclusion, these findings suggest that FXT could be a promising lead compound to be used as a novel STAT3 inhibitor and potential antitumor agent for the treatment of NSCLC. PMID: 31080186 [PubMed - in process] (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - May 14, 2019 Category: Research Authors: Zhang Y, Wang L, Deng Y, Zhao P, Deng W, Zhang J, Luo J, Li R Tags: Tohoku J Exp Med Source Type: research

Synovial Fat Deposition of the Knee Is Associated with Degenerative Joint Disorder.
Abstract Synovial fat deposition, also known as lipoma arborescens, is a rare articular disorder with villous synovial proliferation, commonly seen in the knee. We explored the relationship between the degree of synovial fat deposition on the magnetic resonance imaging (MRI) and the severity of degenerative joint disorder, also called osteoarthritis, on plain radiography. The enrolled patients underwent MRI with a 0.4T permanent magnetic unit in a single institution over a 9-month period. The indications of MRI were chronic knee disorder of non-specific cause. Patients with minor trauma were also included. Consecu...
Source: The Tohoku Journal of Experimental Medicine - May 14, 2019 Category: Research Authors: Suzuki T, Ehara S Tags: Tohoku J Exp Med Source Type: research

Miyagi Medical and Welfare Information Network: A Backup System for Patient Clinical Information after the Great East Japan Earthquake and Tsunami.
Abstract On March 11, 2011, the Great East Japan Earthquake and ensuing tsunami that hit the northeastern coastal region of Japan caused about 18,000 casualties and destroyed numerous buildings. Additionally, many medical facilities were damaged and patient medical records lost. In order to maintain patient clinical information, a prefectural medical network system, the Miyagi Medical and Welfare Information Network (MMWIN), began providing backup data storage services in 2013 for hospitals, clinics, pharmacies, and other care facilities as a precaution for upcoming disasters. This system also facilitates the shar...
Source: The Tohoku Journal of Experimental Medicine - May 14, 2019 Category: Research Authors: Ido K, Nakamura N, Nakayama M Tags: Tohoku J Exp Med Source Type: research

Antiresorptive Agents and Anti-Angiogenesis Drugs in the Development of Osteonecrosis of the Jaw.
Abstract Medication-related osteonecrosis of the jaw (MRONJ) is a condition of exposed bone in the maxillofacial region, which occurs among subjects treated with antiresorptive agents or anti-angiogenesis drugs, despite the lack of a history of head or neck radiation treatment. Although there are still many points to be clarified about the mechanism of MRONJ, it is possible to hypothesize a common pathogenetic mechanism for two different classes of drugs: antiresorptive and anti-angiogenetic drugs. These drugs can inhibit angiogenesis by interfering with endothelial cell proliferation and survival, leading to loss...
Source: The Tohoku Journal of Experimental Medicine - May 14, 2019 Category: Research Authors: Allegra A, Innao V, Pulvirenti N, Musolino C Tags: Tohoku J Exp Med Source Type: research

Association between Tumor Necrosis Factor- α Promoter -308 G/A Polymorphism and Early Onset Sepsis in Preterm Infants.
Association between Tumor Necrosis Factor-α Promoter -308 G/A Polymorphism and Early Onset Sepsis in Preterm Infants. Tohoku J Exp Med. 2019;247(4):259-264 Authors: Varljen T, Rakic O, Sekulovic G, Jekic B, Maksimovic N, Janevski MR, Novakovic I, Damnjanovic T Abstract Early-onset neonatal sepsis (EOS) is diagnosed during the first 7 days of neonatal life and is the major cause of morbidity and mortality among preterm infants. Genetic predisposition may have an impact on EOS susceptibility and outcome. The aim of our study was to explore the association between TNF-α -308 G/A or IL-6 -174 ...
Source: The Tohoku Journal of Experimental Medicine - April 24, 2019 Category: Research Authors: Varljen T, Rakic O, Sekulovic G, Jekic B, Maksimovic N, Janevski MR, Novakovic I, Damnjanovic T Tags: Tohoku J Exp Med Source Type: research

Usefulness of Gastric Aspirate Culture for Diagnosing Congenital Immunodeficiency in an Infant with Fungal Pneumonia Caused by Rasamsonia piperina.
We report the case of a 2-month-old boy with CGD, in which gastric aspirate culture was used to diagnose fungal pneumonia. Rasamsonia piperina was isolated from the gastric aspirate, and the patient was successfully treated with micafungin based on the drug susceptibility test results for the fungal isolate. The acid tolerance test revealed that R. piperina could grow at pH 2, indicating high acid resistance. Although we can only report our experience with a single case, gastric aspirate culture may be a useful tool for detecting fungal respiratory pathogens in children with primary immunodeficiency. Detecting these pathog...
Source: The Tohoku Journal of Experimental Medicine - April 24, 2019 Category: Research Authors: Fujita Y, Ishiwada N, Takei H, Suwabe SI, Yarita K, Ohkusu M, Muraosa Y, Kamei K, Shimojo N Tags: Tohoku J Exp Med Source Type: research

Precision Radiotherapy and Radiation Risk Assessment: How Do We Overcome Radiogenomic Diversity?
Abstract Precision medicine is a rapidly developing area that aims to deliver targeted therapies based on individual patient characteristics. However, current radiation treatment is not yet personalized; consequently, there is a critical need for specific patient characteristics of both tumor and normal tissues to be fully incorporated into dose prescription. Furthermore, current risk assessment following environmental, occupational, or accidental exposures to radiation is based on population effects, and does not account for individual diversity underpinning radiosensitivity. The lack of personalized approaches i...
Source: The Tohoku Journal of Experimental Medicine - April 13, 2019 Category: Research Authors: Fukunaga H, Yokoya A, Taki Y, Butterworth KT, Prise KM Tags: Tohoku J Exp Med Source Type: research

Low-Dose Carbon Monoxide Inhibits Rhinovirus Replication in Human Alveolar and Airway Epithelial Cells.
This study investigated whether the exogenous application of low-dose CO could inhibit RV replication in human alveolar and airway epithelial cells. A549 human lung carcinoma cells with alveolar epithelial features and primary cultures of human tracheal epithelial (HTE) cells were pretreated with CO (100 ppm) and infected with a major group RV, type 14 RV (RV14). CO exposure reduced RV14 titers in the supernatants and RV RNA levels in A549 and HTE cells. The treatment with a guanylate cyclase inhibitor, 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one, reversed the inhibitory effects of CO exposure on RV14 replication in A549 c...
Source: The Tohoku Journal of Experimental Medicine - April 13, 2019 Category: Research Authors: Deng X, Yasuda H, Sasaki T, Yamaya M Tags: Tohoku J Exp Med Source Type: research

Infection Control in Nursery Schools and Schools Using a School Absenteeism Surveillance System.
In conclusion, advice from a public health center given by phone based on information from (N)SASSy will be helpful for reducing the number of clusters of infectious diseases, except for HFMD and influenza. PMID: 30867342 [PubMed - in process] (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - March 15, 2019 Category: Research Authors: Tanabe Y, Kurita J, Nagasu N, Sugawara T, Ohkusa Y Tags: Tohoku J Exp Med Source Type: research

Equality of Treatment for Hip Fracture Irrespective of Regional Differences in Socioeconomic Status: Analysis of Nationwide Hospital Claims Data in Japan.
Abstract Despite the wide variety of international evidence on the relationship between the socioeconomic status (SES) and health outcomes, less is known about the association between SES and healthcare provider practices. We assessed whether patients with a closed hip fracture were treated differently by hospital physicians according to the SES of their residential areas in Japan. Hip fracture is a common cause of hospitalization among the elderly, but the relationship between SES and hip fracture treatment remains unknown in Japan. We employed the Diagnosis Procedure Combination (DPC) database from April 2011 to...
Source: The Tohoku Journal of Experimental Medicine - March 15, 2019 Category: Research Authors: Tomioka S, Fujino Y, Nakaya T, Ohtani M, Kubo T, Matsuda S Tags: Tohoku J Exp Med Source Type: research

Functional Heme Binding to the Intrinsically Disordered C-Terminal Region of Bach1, a Transcriptional Repressor.
Abstract Heme is one of the key factors involved in the oxidative stress response of cells. The transcriptional repressor Bach1 plays an important role in this response through its heme-binding activity. Heme inhibits the transcriptional-repressor activity of Bach1, and can occur in two binding modes: 5- and 6-coordinated binding. The Cys-Pro (CP) motif has been determined to be the heme-binding motif of Bach family proteins. The sequence of Bach1 includes six CP motifs, and four CP motifs are functional. With the aim of elucidating the molecular mechanism of heme-Bach1 regulation, we conducted biophysical analyse...
Source: The Tohoku Journal of Experimental Medicine - March 12, 2019 Category: Research Authors: Segawa K, Watanabe-Matsui M, Matsui T, Igarashi K, Murayama K Tags: Tohoku J Exp Med Source Type: research

Critically Severe Case of Neonatal Herpes with High Viral Load and Hemophagocytic Syndrome.
Abstract Neonatal disseminated herpes simplex virus (HSV) infection is a severe disease with high mortality and morbidity; yet, the pathophysiology remains unclear. Here, we report a male infant with disseminated HSV type 1 (HSV-1) infection, complicated by hemophagocytic lymphohistiocytosis (HLH) and multiple organ failure. The infant, born at 39 weeks of gestation by normal delivery, developed fever (38.5˚C) with the high serum C-reactive protein levels on the 1st day of life, and exhibited tachypnea on the 3rd day. On the 5th day of life, the patient received mechanical ventilation and was transferred to our n...
Source: The Tohoku Journal of Experimental Medicine - March 5, 2019 Category: Research Authors: Takehara H, Hirohata K, Mutoh H, Irisa C, Kakiuchi S, Nishimura R, Oka A, Takahashi N Tags: Tohoku J Exp Med Source Type: research

Relation of High Social Capital to Preferable Emotional Response to News Media Broadcasting of Natural Disasters: A Nationwide Cross-Sectional Study in Japan.
Abstract Media coverage of disasters potentially damages mental health. Moreover, its effects may differ as recipients may have different emotional responses toward media. The present study examined whether social capital, known to be protective against mental problems, influences a recipient's emotional response toward news media broadcasting of natural disasters via newspapers, television and internet in Japan. Three social capital components, social participation, social support and cognitive social capital, were considered in the present study as each component reportedly had different effect on mental health....
Source: The Tohoku Journal of Experimental Medicine - February 26, 2019 Category: Research Authors: Horiuchi S, Ozaki A, Inoue M, Aida J, Yamaoka K Tags: Tohoku J Exp Med Source Type: research

The 10-Min Holistic Self-Care for Patients with Breast Cancer-Related Lymphedema: Pilot Randomized Controlled Study.
In conclusion, the patients who practiced the holistic BCRL self-care for 6 months have shown greater improvement. PMID: 30799328 [PubMed - in process] (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - February 26, 2019 Category: Research Authors: Arinaga Y, Piller N, Sato F, Ishida T, Ohtake T, Kikuchi K, Sato-Tadano A, Tada H, Miyashita M Tags: Tohoku J Exp Med Source Type: research

Renal Epithelioid Angiomyolipoma Undergoing Aggressive Clinical Outcome: The MDM2 Expression in Tumor Cells of Two Cases.
In conclusion, this is the first study demonstrating that MDM2 could play an important role in the molecular mechanisms of recurrence/metastasis of EAML. Further analyses focusing on MDM2 pathway could contribute to the identification of novel prognostic factors and/or therapeutic targets in EAML patients. PMID: 30799331 [PubMed - in process] (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - February 26, 2019 Category: Research Authors: Inoue C, Saito R, Nakanishi W, Kumata H, Eba S, Fujishima F, Watanabe M, Sasano H Tags: Tohoku J Exp Med Source Type: research

Early Initiation of Post-Pyloric Feeding in Patients with Major Burns: Experience in Taiwan Formosa Water Park Dust Explosion Disaster.
In conclusion, our findings indicate that the time from injury to the onset of post-pyloric feeding is crucial, and EPF allows for the administration of calculated caloric needs. Therefore, EPF can be successfully initiated with beneficial outcomes of nutritional reconstruction in severely burned patients. PMID: 30787234 [PubMed - in process] (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - February 23, 2019 Category: Research Authors: Tseng YC, Chen BC, Chen CT, Chou YC, Dai NT, Chen PJ, Huang TY, Shih YL, Chang WK, Hsieh TY, Lin JC Tags: Tohoku J Exp Med Source Type: research

Association between Family History of Cancer and Lung Cancer Risk among Japanese Men and Women.
Abstract Although cigarette smoking is a major risk factor for lung cancer, genetic susceptibility may also affect lung cancer risk. To explore the role of genetic risk, this case-control study investigated the association between family history of cancer at several sites and lung cancer risk. A total of 1,733 lung cancer cases and 6,643 controls were selected from patients aged 30 years and over admitted to a single hospital in Japan between 1997 and 2009. Information on family history of cancer was collected using a self-administered questionnaire and odds ratios (ORs) were estimated by unconditional logistic re...
Source: The Tohoku Journal of Experimental Medicine - February 23, 2019 Category: Research Authors: Yoshida K, Takizawa Y, Nishino Y, Takahashi S, Kanemura S, Omori J, Kurosawa H, Maemondo M, Minami Y Tags: Tohoku J Exp Med Source Type: research

Interleukin-17: The Role for Pathological Angiogenesis in Ocular Neovascular Diseases.
Abstract Ocular neovascular diseases are featured by abnormal angiogenesis in the eye, and they seriously threaten the human visual health. These diseases include proliferative diabetic retinopathy (PDR), age-related macular degeneration (AMD), retinopathy of prematurity (ROP), and retinal vein occlusion (RVO). In fact, ocular neovascular diseases represent the leading causes of vision impairment and blindness worldwide. Ocular neovascularization, the process of pathological vessel formation in eye, underlies ocular neovascular diseases. Cytokines have important regulatory roles in neovascularization through immun...
Source: The Tohoku Journal of Experimental Medicine - February 19, 2019 Category: Research Authors: Li Y, Zhou Y Tags: Tohoku J Exp Med Source Type: research

Antiresorptive Agent-Related Osteonecrosis of the Jaw (ARONJ): A Twist of Fate in the Bone.
This article overviews the concept of MRONJ by focusing on antiresorptive agents and the status of BRONJ in Japan. PMID: 30713280 [PubMed - in process] (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - February 6, 2019 Category: Research Authors: Shibahara T Tags: Tohoku J Exp Med Source Type: research