Microarray Expression Profiling of microRNAs Reveals Potential Biomarkers for Hepatocellular Carcinoma.
Abstract Hepatocellular carcinoma (HCC) remains a major health problem for delayed diagnosis, inefficient surveillance and poor prognosis. Recent studies have indicated that non-coding RNAs contribute to the development of new strategies for diagnosis and treatment of HCC. In the present study, we employed 18 pairs of HCC and matched non-tumor tissues for the identification of differentially expressed microRNAs (miRNAs) in HCC, among which 7 paired specimens were selected randomly for microarray detection. Totally, twenty-three miRNAs were screened out to have statistically significant differences with the threshold of P
Source: The Tohoku Journal of Experimental Medicine - June 16, 2018 Category: Research Authors: Zhu HR, Huang RZ, Yu XN, Shi X, Bilegsaikhan E, Guo HY, Song GQ, Weng SQ, Dong L, Janssen HLA, Shen XZ, Zhu JM Tags: Tohoku J Exp Med Source Type: research

Decreased Respiratory Muscle Function Is Associated with Impaired Trunk Balance among Chronic Stroke Patients: A Cross-sectional Study.
Abstract The abdominal muscles play a role in trunk balance. Abdominal muscle thickness is asymmetrical in stroke survivors, who also have decreased respiratory muscle function. We compared the thickness of the abdominal muscles between the affected and less affected sides in stroke survivors. In addition, the relationship between respiratory muscle function and trunk balance was evaluated. Chronic stroke patients (18 men, 15 women; mean age, 58.94 ± 12.30 years; Mini-Mental Status Examination score ≥ 24) who could sit without assist were enrolled. Abdominal muscle thickness during rest and contraction w...
Source: The Tohoku Journal of Experimental Medicine - June 2, 2018 Category: Research Authors: Lee K, Cho JE, Hwang DY, Lee W Tags: Tohoku J Exp Med Source Type: research

Onset of Hemophagocytic Lymphohistiocytosis during Piperacillin-Tazobactam Therapy in Three Children with Acute Focal Bacterial Nephritis.
In conclusion, prolonged antibiotic therapy with PIPC-TAZ could be a cause of HLH. PMID: 29798969 [PubMed - in process] (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - May 30, 2018 Category: Research Authors: Miyabayashi H, Kumaki S, Sato A, Onuma R, Noguchi R, Sato T, Metoki T, Watanabe Y, Tazawa Y, Imaizumi M, Kitaoka S Tags: Tohoku J Exp Med Source Type: research

Serum Levels of TRIM72 Are Lower among Patients with Colon Cancer: Identification of a Potential Diagnostic Marker.
In conclusion, serum TRIM72 may be a potential biomarker for the diagnosis and the prognosis of colon cancer. PMID: 29806630 [PubMed - in process] (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - May 30, 2018 Category: Research Authors: Chen Z, Yin X, Li K, Chen S, Li H, Li Y, Zhang Q, Wang H, Qiu Y Tags: Tohoku J Exp Med Source Type: research

Altered Wnt and NF- κB Signaling in Facet Joint Osteoarthritis: Insights from RNA Deep Sequencing.
Altered Wnt and NF-κB Signaling in Facet Joint Osteoarthritis: Insights from RNA Deep Sequencing. Tohoku J Exp Med. 2018;245(1):69-77 Authors: Chen C, Bao GF, Xu G, Sun Y, Cui ZM Abstract Facet joint osteoarthritis is common lumbar osteoarthritis characterized by facet joint cartilage degeneration. However, the molecular basis of facet joint osteoarthritis remains largely undetermined. In the current study, we collected facet joint tissue samples from 10 control patients and 48 patients with facet joint osteoarthritis (20 patients with moderate degeneration and 28 with severe degeneration). The ...
Source: The Tohoku Journal of Experimental Medicine - May 30, 2018 Category: Research Authors: Chen C, Bao GF, Xu G, Sun Y, Cui ZM Tags: Tohoku J Exp Med Source Type: research

Leptin Aggravates Reflux Esophagitis by Increasing Tissue Levels of Macrophage Migration Inhibitory Factor in Rats.
In conclusion, through enhancing the MIF-induced inflammatory signaling, leptin could contribute to the development of gastroesophageal reflux disease. PMID: 29760351 [PubMed - in process] (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - May 17, 2018 Category: Research Authors: Murata T, Asanuma K, Ara N, Iijima K, Hatta W, Hamada S, Asano N, Koike T, Imatani A, Masamune A, Shimosegawa T Tags: Tohoku J Exp Med Source Type: research

Time-Dependent Changes in Local and Serum Levels of Inflammatory Cytokines as Markers for Incised Wound Aging of Skeletal Muscles.
Abstract Wound age estimation is an important research field in forensic pathology. The expression levels of cytokines in the incised skeletal muscle were analyzed using a mouse model to explore the applicability for wound aging. A 5-mm long incisional wound was made at the biceps femoris muscle, and the muscle and serum were sampled at 6, 12, 24 and 48 hours after injury. Using a multiplex bead-based immunoassay, we measured the tissue levels of nine cytokines (IL-1β, IL-6, IL-7, CCL2, CCL3, CCL4, CXCL1, CXCL2, and CXCL10), which are all involved in the pathways of inflammatory response and tissue injury. Im...
Source: The Tohoku Journal of Experimental Medicine - May 17, 2018 Category: Research Authors: Gaballah MH, Horita T, Takamiya M, Yokoji K, Fukuta M, Kato H, Aoki Y Tags: Tohoku J Exp Med Source Type: research

Direct and Indirect Harassment Experiences and Burnout among Academic Faculty in Japan.
Abstract The purpose of this study is three-fold: (1) to compare harassment (sexual, gender, and academic harassment both directly and indirectly experienced - i.e. "directly harassed" and "have seen or heard of someone who experienced harassment", respectively) experienced by males and females, (2) to investigate whether such experiences correlate with burnout, and (3) to explore whether social support might mitigate any such relationship between harassment and burnout. This cross-sectional study was conducted at a private university in Japan in February 2014 and is based on a work-life balanc...
Source: The Tohoku Journal of Experimental Medicine - May 17, 2018 Category: Research Authors: Takeuchi M, Nomura K, Horie S, Okinaga H, Perumalswami CR, Jagsi R Tags: Tohoku J Exp Med Source Type: research

Intermittent Withdrawal of Oxaliplatin for Alleviating Neurotoxicity during Oxaliplatin-Based Chemotherapy for Japanese Patients with Inoperable or Metastatic Colorectal Cancer: A Phase 2 Multicenter Study.
Abstract Oxaliplatin-based chemotherapy is a well-established regimen for patients with inoperable and metastatic colorectal cancer. However, one of the major limitations of oxaliplatin-based chemotherapy is sensory neuropathy. It was previously reported that introduction of intermittent oxaliplatin treatment to an oxaliplatin-based regimen has a significant benefit on efficacy or safety. Here, we prospectively assessed whether efficacy and safety of first-line chemotherapy for advanced colorectal cancer are achieved by introduction of withdrawal of oxaliplatin treatment for a certain period (intermittent oxalipla...
Source: The Tohoku Journal of Experimental Medicine - May 11, 2018 Category: Research Authors: Kato S, Imai H, Gamoh M, Takahata T, Ohori H, Yasuda K, Niitani T, Murakawa Y, Amagai K, Isobe H, Shindo Y, Kuroki M, Sakamoto Y, Shimodaira H, Yoshioka T, Ishioka C Tags: Tohoku J Exp Med Source Type: research

Newly-Developed Positron Emission Mammography (PEM) Device for the Detection of Small Breast Cancer.
Abstract Positron emission mammography (PEM) has higher detection sensitivity for breast cancer compared with whole-body positron emission tomography (PET) due to higher spatial resolution. We have developed a new PEM device with high resolution over a wide field of view. This PEM device comprises novel scintillation crystals, praseodymium-doped lutetium aluminum garnet (Pr:LuAG). In the present study, the clinical use of the newly developed PEM for the detection of small breast cancer was compared with that of the conventional PET-computed tomography (PET/CT). Eighty-two patients with breast cancer less than 20 m...
Source: The Tohoku Journal of Experimental Medicine - May 9, 2018 Category: Research Authors: Yanai A, Itoh M, Hirakawa H, Yanai K, Tashiro M, Harada R, Yoshikawa A, Yamamoto S, Ohuchi N, Ishida T Tags: Tohoku J Exp Med Source Type: research

Coexistence of IL-6 -572C/G and ICAM-1 K469E Polymorphisms among Patients with Sudden Sensorineural Hearing Loss.
In this study, we explored the relationship between SSNHL with IL-6 -572C/G and ICAM-1 K469E polymorphisms. We conducted a case-control study including 75 SSNHL patients and 165 healthy controls and analyzed the distribution and odds ratios of IL-6 and ICAM-1 genotypes. The frequency of the G allele at IL-6 -572C/G polymorphism was significantly higher among SSNHL patients than that among healthy individuals. In multivariate analysis, the coexistence of IL-6 -572G allele (GG/CG) and E allele (EE/KE) of ICAM-1 K469E polymorphism was significantly associated with an increased SSNHL risk (P
Source: The Tohoku Journal of Experimental Medicine - April 27, 2018 Category: Research Authors: Tian G, Zhang S, Yang J Tags: Tohoku J Exp Med Source Type: research

Detection of Acetaldehyde in the Esophageal Tissue among Healthy Male Subjects after Ethanol Drinking and Subsequent L-Cysteine Intake.
In conclusion, we detected acetaldehyde in the human esophageal tissue after ethanol drinking. Unexpectedly, intake of L-cysteine lozenges appears to contribute to detection of acetaldehyde in the esophageal tissue. PMID: 29681559 [PubMed - in process] (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - April 24, 2018 Category: Research Authors: Okata H, Hatta W, Iijima K, Asanuma K, Tsuruya A, Asano N, Koike T, Hamada S, Nakayama T, Masamune A, Shimosegawa T Tags: Tohoku J Exp Med Source Type: research

Subchondral Insufficiency Fracture of the Femoral Head in a Pregnant Woman with Pre-existing Anorexia Nervosa.
Abstract Subchondral insufficiency fracture (SIF) is a fragility fracture secondary to osteoporosis that leads to collapse of the femoral head with no evidence of osteonecrosis. SIF of the femoral head has been reported in adults of varying ages and both sexes, but it has never been reported to occur in pregnant women. Herein, we describe a 40-year-old primiparous patient with pre-existing anorexia nervosa who developed SIF of the femoral head in the third trimester. At 29 weeks of gestation, the patient complained of sudden pain on walking in both hips. Despite the bed rest, her hip pain increased; consequently, ...
Source: The Tohoku Journal of Experimental Medicine - April 24, 2018 Category: Research Authors: Kasahara K, Mimura T, Moritani S, Kawasaki T, Imai S, Tsuji S, Kimura F, Murakami T Tags: Tohoku J Exp Med Source Type: research

Reduction in Door-to-Balloon Time with Training for Effective and Efficient Action in Medical Service-Better Process (TEAMS-BP) at a Community Hospital in Japan.
In conclusion, implementation of TEAMS-BP improved the door-to-balloon time of STEMI cases without additional resources or costs incurred by the hospital. TEAMS-BP can be implemented by any hospital wishing to develop a new process that accommodates local working conditions. PMID: 29657235 [PubMed - in process] (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - April 17, 2018 Category: Research Authors: Isono H, Maeno T, Watanabe S Tags: Tohoku J Exp Med Source Type: research

Hypocarnitinemia Observed in an Infant Treated with Short-Term Administration of Antibiotic Containing Pivalic Acid.
Abstract Carnitine is a water-soluble amino acid derivative required for β-oxidation of long-chain fatty acids. In carnitine cycle abnormalities and low carnitine states, fatty acid β-oxidation is inhibited during fasting, resulting in hypoglycemia. Pivalic acid is a substance used in prodrugs to increase absorption of parent drugs, and antibiotics containing pivalic acid are frequently used as wide spectrum antibiotics for pediatric patients in Japan. Pivalic acid released after absorption is conjugated with free carnitine to form pivaloylcarnitine, which is then excreted in urine. As a consequence, lon...
Source: The Tohoku Journal of Experimental Medicine - April 10, 2018 Category: Research Authors: Nakazaki K, Ogawa E, Ishige M, Ishige N, Fuchigami T, Takahashi S Tags: Tohoku J Exp Med Source Type: research

Prevalence of Escherichia coli Resistant to Beta-Lactam Antibiotics among Patients with Chronic Obstructive Pulmonary Disease and Urinary Tract Infection.
In this study, we analyzed 580 patients with COPD (236 females and 344 males) and thus found 218 patients with co-morbid UTIs, including 58 patients with UTI caused by E. coli (38 females and 20 males). We also investigated cases of uncomplicated symptomatic and asymptomatic UTI caused by E. coli and the presence of resistance to beta-lactam antibiotics among those patients. The E. coli strains resistant to beta-lactam antibiotics were selected for their ability to grow on selective media, before DNA microarrays were applied for specific identification of three beta-lactamase gene types (i.e., TEM, SHV and CTX-M). Overall,...
Source: The Tohoku Journal of Experimental Medicine - April 7, 2018 Category: Research Authors: Nikolić E, Brandmajer T, Bokan V, Ulyashova M, Rubtsova M Tags: Tohoku J Exp Med Source Type: research

Oral Fat Sensitivity Is Associated with Social Support for Stress Coping in Young Adult Men.
Abstract Oral fat sensitivity (OFS), the ability to taste fat, is associated with eating habits in humans, including daily fatty food consumption; namely, proper OFS is important for health. In addition, lifestyle factors, such as stress and sleep, may affect fat intake. However, correlations between OFS, stress management, and sleep are largely unknown. Thus, we investigated the associations of OFS with lifestyle factors regarding stress management and daytime sleepiness in healthy young adult men. We measured OFS, sensitivities for three prototypical tastes (sweet, salty, and sour), and BMI in 22 subjects (27.2 ...
Source: The Tohoku Journal of Experimental Medicine - March 28, 2018 Category: Research Authors: Tanaka T, Hong G, Tominami K, Kudo TA Tags: Tohoku J Exp Med Source Type: research

Interleukin-35 as a New Biomarker of Renal Involvement in Lupus Nephritis Patients.
Abstract Systemic lupus erythematosus (SLE) is an autoimmune connective tissue disease with a wide range of clinical presentations. Lupus nephritis (LN) is the most serious manifestation of SLE. Interleukin-35 (IL-35), a member of the interleukin-12 family, has been identified as a novel anti-inflammatory cytokine. In the past ten years, the role of IL-35 in inflammatory and autoimmune diseases has been studied extensively. Serum IL-35 levels, however, have not been studied in LN patients. The aim of the study was to determine serum IL-35 levels in SLE patients with and without nephritis, and their clinical values...
Source: The Tohoku Journal of Experimental Medicine - March 28, 2018 Category: Research Authors: He D, Liu M, Liu B Tags: Tohoku J Exp Med Source Type: research

Reduction in Prevalence of Hypertension and Blood Heavy Metals among Curry-Consumed Korean.
The objective of the present study was to determine whether curry intake reduces blood levels of heavy metals and hypertension (HTN) using Korean National Health and Nutrition Examination Survey 2013 data (n = 1,350). Study subjects (n = 1,350) were divided into two groups: 1) a curry intake group (n = 603), members of which had consumed a curry dish more than once a month over the previous year, and 2) a non-curry intake group (n = 747). Analysis showed the curry intake group had significantly lower heavy metal blood concentrations (Pb, Hg, and Cd) and blood concentrations of heavy metals were significantly associated wit...
Source: The Tohoku Journal of Experimental Medicine - March 27, 2018 Category: Research Authors: Choi JW, Oh C, Shim SY, Jeong S, Kim HS, Kim MS Tags: Tohoku J Exp Med Source Type: research

Prevalence of Opportunistic Infections and Causes of Death among Hospitalized HIV-Infected Patients in Sichuan, China.
Abstract Opportunistic infections (OIs) are the most significant complication of human immunodeficiency virus (HIV) infection. The prevalence of OIs differs among various countries in part due to different climates and socio-economic conditions. We, therefore, carried out the retrospective study at the Public Health Clinical Center of Chengdu, Sichuan to comprehensively investigate the prevalence of OIs, predictors of OIs, and risk factors for in-hospital death among HIV-infected patients. Sichuan in West China is characterized by the largest population living with HIV/Acquired immunodeficiency syndrome (AIDS) acr...
Source: The Tohoku Journal of Experimental Medicine - March 27, 2018 Category: Research Authors: Pang W, Shang P, Li Q, Xu J, Bi L, Zhong J, Pei X Tags: Tohoku J Exp Med Source Type: research

Vitamin B3 Nicotinamide: A Promising Candidate for Treating Preeclampsia and Improving Fetal Growth.
Abstract Up to 8% of pregnant women suffer from preeclampsia (PE), a deadly disease characterized by high blood pressure (BP), blood vessel damage, called endotheliosis (vascular endothelial swelling with narrowing of capillary lumen), and high levels of protein in the urine. PE is often associated with premature delivery, which is a risk factor of cardiovascular and metabolic diseases among the offspring. Accordingly, establishing drug treatments of PE is in immediate needs. Currently, many of anti-hypertensive drugs cause malformation of the fetuses and are contraindicated for pregnant women. Anti-hypertensive d...
Source: The Tohoku Journal of Experimental Medicine - March 27, 2018 Category: Research Authors: Takahashi N, Li F, Fushima T, Oyanagi G, Sato E, Oe Y, Sekimoto A, Saigusa D, Sato H, Ito S Tags: Tohoku J Exp Med Source Type: research

Correlation between Mechanical Properties of the Ankle Muscles and Postural Sway during the Menstrual Cycle.
Abstract Ankle and foot injuries are common among athletes and physically active individuals. The most common residual disability, ankle sprain, is characterized by instability along with postural sway. If the supporting structures around a joint become lax, posture stability and balance are also affected. Previous studies have examined muscle stiffness and elasticity and postural sway separately; however, the relationship between these factors is yet unknown. It is well known that the levels of sex hormones, especially estrogen, change in women over the phase of the menstrual cycle. Therefore, this study examined...
Source: The Tohoku Journal of Experimental Medicine - March 17, 2018 Category: Research Authors: Yim J, Petrofsky J, Lee H Tags: Tohoku J Exp Med Source Type: research

Low Cancer Screening Rates among Japanese People with Schizophrenia: A Cross-Sectional Study.
This study aimed to investigate records-based cancer screening rates, focusing on participation rates of people with schizophrenia who are subject to municipal cancer screening programs. We conducted a cross-sectional study at a psychiatric hospital outpatient clinic from September to November 2016. We randomly extracted 420 potential participants from among 680 eligible patients and asked them to participate. We then selected subgroups of participants living in Okayama city who were enrolled in the National Health Insurance or Public Assistance systems and were subject to colorectal, gastric, lung, breast, or cervical can...
Source: The Tohoku Journal of Experimental Medicine - March 17, 2018 Category: Research Authors: Inagaki M, Fujiwara M, Nakaya N, Fujimori M, Higuchi Y, Hayashibara C, So R, Kakeda K, Kodama M, Uchitomi Y, Yamada N Tags: Tohoku J Exp Med Source Type: research

Wntless Is Highly Expressed in Advanced-Stage Intrahepatic Cholangiocarcinoma.
Abstract Intrahepatic cholangiocarcinoma (ICC) is an aggressive malignancy of the bile duct, representing the second most common primary liver cancer. Wntless (Wls) is a highly conserved transmembrane protein that shuttles palmitoylated Wnt proteins from the endoplasmic reticulum to the plasma membrane. Wls is highly expressed in various types of cancers and is essential for cell proliferation, anti-apoptotic activity, and survival. The profile of Wls expression and its clinical significance has not been well clarified in ICC. In the present study, we analyzed Wls expression in a set of ICC tissues (n = 44) by imm...
Source: The Tohoku Journal of Experimental Medicine - March 14, 2018 Category: Research Authors: Shi Y, Bai J, Guo S, Wang J Tags: Tohoku J Exp Med Source Type: research

Protein Tyrosine Phosphatase SHP-2 Is Involved in the Interleukin-21-Induced Activation of Extracellular Signal-Regulated Kinase 1/2.
Abstract The cytokine interleukin-21 (IL-21) is mainly produced from activated CD4+ T cells and natural killer T (NKT) cells. IL-21 enhances the proliferation and differentiation of T cells and B cells and also increases cytotoxicity of CD8+ T cells and NK cells through the IL-21 receptor and its downstream signaling molecules such as signal transducers and activator of transcription 3 (STAT3) and extracellular signal-regulated kinase 1/2 (ERK1/2). SH2 domain-containing tyrosine phosphatase (SHP-2) is ubiquitously expressed, including hematopoietic cells. SHP-2 has been implicated in the regulation of IL-6 and IL-...
Source: The Tohoku Journal of Experimental Medicine - March 7, 2018 Category: Research Authors: Jin L, Nara H, Rahman M, Takeda Y, Araki A, Asao H Tags: Tohoku J Exp Med Source Type: research

Copayment Exemption Policy and Healthcare Utilization after the Great East Japan Earthquake.
Abstract Healthcare utilization after natural disasters remains understudied. In general, people in Japan pay 10%-30% of total amount of costs, according to their health insurance plan. A policy exempting survivors from copayments was introduced after the Great East Japan Earthquake in March 2011, which had a magnitude of 9.0 on the Richter scale and followed by devastating tsunamis. Among the disaster-affected areas, Miyagi prefecture experienced the largest number of deaths and the greatest extent of damage. However, the exemption was suspended in Miyagi prefecture from April, 2013, because of the huge governmen...
Source: The Tohoku Journal of Experimental Medicine - March 7, 2018 Category: Research Authors: Matsuyama Y, Tsuboya T, Bessho SI, Aida J, Osaka K Tags: Tohoku J Exp Med Source Type: research

Shox2: The Role in Differentiation and Development of Cardiac Conduction System.
Abstract The formation and conduction of electrocardiosignals and the synchronous contraction of atria and ventricles with rhythmicity are both triggered and regulated by the cardiac conduction system (CCS). Defect of this system will lead to various types of cardiac arrhythmias. In recent years, the research progress of molecular genetics and developmental biology revealed a clearer understanding of differentiation and development of the cardiac conduction system and their regulatory mechanisms. Short stature homeobox 2 (Shox2) transcription factor, encoded by Shox2 gene in the mouse, is crucial in the formation ...
Source: The Tohoku Journal of Experimental Medicine - March 7, 2018 Category: Research Authors: Hu W, Xin Y, Zhao Y, Hu J Tags: Tohoku J Exp Med Source Type: research

Saltatory Conduction as an Electrostatic Compressional Wave in the Axoplasm.
In this report, I propose a new model of saltatory conduction by focusing on the behavior of electric charges in the axoplasm, not limited to the membrane. In myelinated nerves, because of the large internodal length and the low ion channel density in the internodal segment, the whole cross-section of the internodal axoplasm would contribute to the signal conduction. Because the conducted signals originate from the sodium ion influx through the voltage-gated sodium (NaV) channel at the Ranvier's nodes, an individual conducted signal can be described as a single electrostatic compressional wave of positive charges in the in...
Source: The Tohoku Journal of Experimental Medicine - February 23, 2018 Category: Research Authors: Akaishi T Tags: Tohoku J Exp Med Source Type: research

Retraction: Nucleophagy in Human Disease: Beyond the Physiological Role. [Tohoku J. Exp. Med., 2018, 244 (1), 75-81. doi: 10.1620/tjem.244.75. Review.].
Abstract Retracted Review article: Nucleophagy in Human Disease: Beyond the Physiological Role. [Tohoku J. Exp. Med., 2018, 244 (1), 75-81. doi: 10.1620/tjem.244.75.]The above Review article was published online on January 27, 2018. Soon after its publication (on February 1, 2018), Dr. Nian Fu and Prof. Linxi Chen informed the Editor-in-Chief, The Tohoku Journal of Experimental Medicine (TJEM), about serious violation of publication ethics. Indeed, Dr. Nian Fu and Prof. Linxi Chen were astonished to find their names as coauthors of this Review article, because they were not involved in the submission process of th...
Source: The Tohoku Journal of Experimental Medicine - February 23, 2018 Category: Research Authors: Zhou M, Ji H, Fu N, Chen L, Xia Y Tags: Tohoku J Exp Med Source Type: research

Potential Role of ASC, a Proapoptotic Protein, for Determining the Cisplatin Susceptibility of Lung Cancer Cells.
Abstract Primary lung cancer is the most frequent cause of cancer-related deaths worldwide. Cisplatin has been used as a key drug in the treatment for patients with lung cancer; however, most of the patients failed to respond to cisplatin within several months, and the mechanisms underlying the cisplatin resistance have not been fully elucidated. Apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) is a key adaptor protein in the formation of inflammasomes. ASC is also involved in apoptotic signaling. Importantly, ASC expression is decreased in lung cancer and various cancers, but ...
Source: The Tohoku Journal of Experimental Medicine - February 22, 2018 Category: Research Authors: Sakaizawa T, Matsumura T, Fujii C, Hida S, Toishi M, Shiina T, Yoshida K, Hamanaka K, Ito KI, Taniguchi S Tags: Tohoku J Exp Med Source Type: research

Neonatal Leukemoid Reaction with Fetal Inflammatory Response Syndrome Is Associated with Elevated Serum Granulocyte Colony Stimulating Factor and Interleukin-6.
Abstract Leukemoid reaction (LR) is a reactive disease that exhibits abnormal blood values similar to leukemia, but not due to leukemia. One report showed that neonatal LR (NLR) was associated with elevated serum granulocyte colony stimulating factor (G-CSF) in only 30% of the study neonates. NLR is not always associated with the elevation of serum G-CSF. NLR was defined as a white blood cell count of ≥ 40 × 103/μL and/or blast cell concentration of> 2%. We have focused on NLR with fetal inflammatory response syndrome (FIRS), defined as a fetal systemic inflammatory reaction triggered by intrauterin...
Source: The Tohoku Journal of Experimental Medicine - February 22, 2018 Category: Research Authors: Nakamura T, Hatanaka D, Kusakari M, Kashima K, Takizawa Y, Takahashi H, Yoshioka T, Takahashi N, Kamohara T Tags: Tohoku J Exp Med Source Type: research

Lower Plasma Levels of IL-35 in Patients with Primary Biliary Cirrhosis.
In this study, we compared plasma levels of IL-35 and relative mRNA expression levels of p35 and Ebi3 in peripheral blood mononuclear cells (PBMCs) from 70 PBC patients and 70 healthy individuals. The results showed that the relative expression levels of Ebi3 mRNA were lower in PBMCs from PBC patients than in PBMCs from healthy individuals, whereas the levels of p35 mRNA were similar in both groups. Plasma IL-35 concentrations were lower in patients with PBC than in healthy individuals. Plasma levels were higher in PBC patients at an advanced stage compared to patients at an early stage. Variable plasma levels with differe...
Source: The Tohoku Journal of Experimental Medicine - February 16, 2018 Category: Research Authors: Li T, Huang Y, Liu P, Liu Y, Guo J, Zhang W, Gu M, Qian C, Deng A Tags: Tohoku J Exp Med Source Type: research

A Missense Mutation in GJA8 Encoding Connexin 50 in a Chinese Pedigree with Autosomal Dominant Congenital Cataract.
In conclusion, c.10T>A (p.W4R) in GJA8 is the newly identified genetic cause of familial congenital cataract. The W-to-R substitution near the amino-terminus may alter the localization of mutant Cx50, thereby impairing gap junction formation, which is the molecular pathogenic mechanism of this mutation. PMID: 29434075 [PubMed - in process] (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - February 13, 2018 Category: Research Authors: Zhang L, Liang Y, Zhou Y, Zeng H, Jia S, Shi J Tags: Tohoku J Exp Med Source Type: research

Differences in Gut Microbiota Profiles between Autoimmune Pancreatitis and Chronic Pancreatitis.
Abstract Host-derived factors alter gut microenvironment, and changes in gut microbiota also affect biological functions of host. Alterations of gut microbiota have been reported in a wide variety of diseases, but the whole picture of alterations in pancreatic diseases remains to be clarified. In particular, the gut microbiota may be affected by malnutrition or impaired exocrine pancreas function that is associated with pancreatic diseases. We here conducted comprehensive analysis of gut microbiota in patients with type 1 autoimmune pancreatitis (AIP), a pancreatic manifestation of the systemic IgG4-related diseas...
Source: The Tohoku Journal of Experimental Medicine - February 13, 2018 Category: Research Authors: Hamada S, Masamune A, Nabeshima T, Shimosegawa T Tags: Tohoku J Exp Med Source Type: research

Low Proportion of Dietary Plant Protein among Athletes with Premenstrual Syndrome-Related Performance Impairment.
Abstract Premenstrual syndrome (PMS) is psychosomatic disorder that are limited to the late luteal phase in the menstrual cycle. PMS could impair athletic performance. To investigate associations between proportions of dietary plant and animal protein and PMS-related impairment of athletic performance, we surveyed 135 female athletes aged 18-23 years attending Kindai University. Participants belonged to authorized university clubs, all of which have high rankings in Japanese university sports. Participants completed self-administered questionnaires on diet history, demographics, and PMS-related impairment of athle...
Source: The Tohoku Journal of Experimental Medicine - February 13, 2018 Category: Research Authors: Yamada K, Takeda T Tags: Tohoku J Exp Med Source Type: research

Time-Dependent Changes in Increased Levels of Plasma Irisin and Muscle PGC-1 α and FNDC5 after Exercise in Mice.
Time-Dependent Changes in Increased Levels of Plasma Irisin and Muscle PGC-1α and FNDC5 after Exercise in Mice. Tohoku J Exp Med. 2018;244(2):93-103 Authors: Pang M, Yang J, Rao J, Wang H, Zhang J, Wang S, Chen X, Dong X Abstract Exercise induces the expression of peroxisome proliferator-activated receptor gamma co-activator 1-α (PGC-1α) in skeletal muscle, which promotes the cleavage of fibronectin type III domain-containing protein 5 (FNDC5) to irisin. To explore the relationship between irisin and its regulators, we analyzed the plasma irisin levels and the muscle levels of FNDC5 ...
Source: The Tohoku Journal of Experimental Medicine - February 9, 2018 Category: Research Authors: Pang M, Yang J, Rao J, Wang H, Zhang J, Wang S, Chen X, Dong X Tags: Tohoku J Exp Med Source Type: research

Prospective Association of Handgrip Strength with Risk of New-Onset Cognitive Dysfunction in Korean Adults: A 6-Year National Cohort Study.
Abstract Dementia is one of the priority public health problems in the older population, and the number of people with dementia is steadily increasing. The longitudinal association of muscle strength with risk of new-onset cognitive dysfunction in a general population including middle and older adults remains unknown. The purpose of this study was to investigate the effects of low muscle strength on risk for new-onset cognitive dysfunction over 6 years using a large nationwide sample of cognitively healthy adults. Study participants included 6,435 middle and older adults (33,554 person-years of follow-up), using d...
Source: The Tohoku Journal of Experimental Medicine - February 6, 2018 Category: Research Authors: Jeong S, Kim J Tags: Tohoku J Exp Med Source Type: research

Nucleophagy in Human Disease: Beyond the Physiological Role.
Abstract Autophagy is an evolutionarily conserved intracellular strategy for degrading organelles and proteins, and nucleophagy refers to the specific process of removing nuclear components from cells by autophagy, Nucleophagy is essential for cell survival by maintaining normal nuclear structure and functions. On the other hand, excessive nucleophagy may result in degradation of essential nuclear components, while impaired nucleophagy may lead to accumulation of harmful metabolic products in the nucleus. Therefore, dysregulation of nucleophagy is likely involved in the pathological process of certain diseases, in...
Source: The Tohoku Journal of Experimental Medicine - January 30, 2018 Category: Research Authors: Zhou M, Ji H, Fu N, Chen L, Xia Y Tags: Tohoku J Exp Med Source Type: research

Increased Expression of Y-Box-Binding Protein-1 in Hind-Limb Muscles During Regeneration from Ischemic Injury in Mice.
Abstract Critical limb ischemia (CLI) is the most severe complication of peripheral arterial disease (PAD). Understanding the molecular mechanisms underlying tissue repair after CLI is necessary for preventing PAD progression. Y-box binding protein-1 (YB-1) regulates the expression of many genes in response to environmental stresses. We aimed to determine whether YB-1 is involved in ischemic muscle regeneration. A mouse ischemic hind-limb model was generated; namely, the femoral, saphenous, and popliteal arteries in the left hind limb were ligated. The right hind limb, with skin incisions alone, served as control....
Source: The Tohoku Journal of Experimental Medicine - January 23, 2018 Category: Research Authors: Fuke M, Narita M, Wada Y, Seto T, Okada K, Nakayama J, Izumi H, Ito KI Tags: Tohoku J Exp Med Source Type: research

Alcohol Consumption and Breast Cancer Risk According to Hormone Receptor Status in Japanese Women: A Case-Control Study.
Abstract Alcohol consumption is a risk factor for breast cancer in Western countries, but few studies have evaluated the risk for Japanese women, who have a relatively low alcohol intake. This case-control study investigated the association of alcohol consumption with breast cancer risk according to estrogen-receptor and progesterone-receptor (ER/PgR) status in Japanese women. From female patients aged 30 years and over admitted to a single hospital in Japan between 1997 and 2011, 1,256 breast cancer cases (669 ER+/PgR+, 162 ER+/PgR-, 21 ER-/PgR+, 305 ER-/PgR-, and 99 missing) and 2,933 controls were selected. Alc...
Source: The Tohoku Journal of Experimental Medicine - January 23, 2018 Category: Research Authors: Takizawa Y, Kawai M, Kakugawa Y, Nishino Y, Ohuchi N, Minami Y Tags: Tohoku J Exp Med Source Type: research

Painless Thyroiditis and Fulminant Type 1 Diabetes Mellitus in a Patient Treated with an Immune Checkpoint Inhibitor, Nivolumab.
Abstract The programmed cell death-1 (PD-1) pathway is a novel therapeutic target in immune checkpoint therapy for cancer. Nivolumab, an anti-PD-1 monoclonal antibody, blocks PD-1 and can restore anti-cancer immune responses by disrupting the signal that inhibits T-cell activation. Nivolumab may induce endocrine-related adverse events, including hypophysitis, autoimmune thyroiditis, and type 1 diabetes mellitus. Here we report a 68-year-old female patient with advanced renal cell carcinoma who was treated with nivolumab. She had positive anti-thyroglobulin antibodies and anti-thyroid peroxidase antibodies with sli...
Source: The Tohoku Journal of Experimental Medicine - January 20, 2018 Category: Research Authors: Sakurai K, Niitsuma S, Sato R, Takahashi K, Arihara Z Tags: Tohoku J Exp Med Source Type: research

Establishment of a Screening System to Identify Novel GATA-2 Transcriptional Regulators.
In conclusion, our system represents a potential tool for identifying novel regulators of GATA-2, thereby contributing to the development of novel therapeutic approaches. PMID: 29343653 [PubMed - in process] (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - January 20, 2018 Category: Research Authors: Ohashi K, Fujiwara T, Onodera K, Saito Y, Ichikawa S, Kobayashi M, Okitsu Y, Fukuhara N, Onishi Y, Harigae H Tags: Tohoku J Exp Med Source Type: research

Higher Incidence of Sleep Disturbance among Survivors with Musculoskeletal Pain after the Great East Japan Earthquake: A Prospective Study.
Abstract Sleep disturbance is a common symptom after natural disasters. Although musculoskeletal pain also increases after natural disasters, its relation to sleep disturbance is not clear. The purpose of this study was to determine the influence of musculoskeletal pain on new-onset sleep disturbance among survivors after the Great East Japan Earthquake (GEJE). A prospective cohort study was conducted with the survivors of the GEJE at two and three years after the earthquake. New-onset sleep disturbance was defined as sleep disturbance absent at two years and present at three years after the earthquake. The sites ...
Source: The Tohoku Journal of Experimental Medicine - January 13, 2018 Category: Research Authors: Yabe Y, Hagiwara Y, Sekiguchi T, Sugawara Y, Tsuchiya M, Koide M, Itaya N, Yoshida S, Sogi Y, Yano T, Tsuji I, Itoi E Tags: Tohoku J Exp Med Source Type: research

Retained Myogenic Potency of Human Satellite Cells from Torn Rotator Cuff Muscles Despite Fatty Infiltration.
Abstract Rotator cuff tears (RCTs) are a common shoulder problem in the elderly that can lead to both muscle atrophy and fatty infiltration due to less physical load. Satellite cells, quiescent cells under the basal lamina of skeletal muscle fibers, play a major role in muscle regeneration. However, the myogenic potency of human satellite cells in muscles with fatty infiltration is unclear due to the difficulty in isolating from small samples, and the mechanism of the progression of fatty infiltration has not been elucidated. The purpose of this study was to analyze the population of myogenic and adipogenic cells ...
Source: The Tohoku Journal of Experimental Medicine - January 10, 2018 Category: Research Authors: Koide M, Hagiwara Y, Tsuchiya M, Kanzaki M, Hatakeyama H, Tanaka Y, Minowa T, Takemura T, Ando A, Sekiguchi T, Yabe Y, Itoi E Tags: Tohoku J Exp Med Source Type: research

Exogenous BMP-7 Facilitates the Recovery of Cardiac Function after Acute Myocardial Infarction through Counteracting TGF- β1 Signaling Pathway.
In conclusion, our data provide a potential therapeutic direction for preserving cardiac function and improving prognosis of AMI patients. PMID: 29279455 [PubMed - in process] (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - December 28, 2017 Category: Research Authors: Jin Y, Cheng X, Lu J, Li X Tags: Tohoku J Exp Med Source Type: research

Exploring Attractiveness of the Basic Sciences for Female Physicians.
Abstract In Japan, traditional gender roles of women, especially the role of motherhood, may cause early career resignations in female physicians and a shortage of female researchers. Besides this gender issue, a general physician shortage is affecting basic science fields. Our previous study suggested that female physicians could be good candidates for the basic sciences because such work offers good work-life balance. However, the attractiveness for female physicians of working in the basic sciences, including work-life balance, is not known. In a 2012 nationwide cross-sectional questionnaire survey, female phys...
Source: The Tohoku Journal of Experimental Medicine - December 28, 2017 Category: Research Authors: Yamazaki Y, Fukushima S, Kozono Y, Uka T, Marui E Tags: Tohoku J Exp Med Source Type: research

Coexistence of Anti-Glomerular Basement Membrane Glomerulonephritis and Membranous Nephropathy in a Female Patient with Preserved Renal Function.
In conclusion, coexisting anti-GBM glomerulonephritis and MN can have preserved renal function. IgG subclass of deposited anti-GBM antibody may be associated with the severity of anti-GBM glomerulonephritis. In addition, in the case of nephrotic syndrome with hematuria, we should consider the possibility of coexisting anti-GBM glomerulonephritis and MN. PMID: 29269610 [PubMed - in process] (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - December 24, 2017 Category: Research Authors: Ogawara A, Harada M, Ichikawa T, Fujii K, Ehara T, Kobayashi M Tags: Tohoku J Exp Med Source Type: research

The Association between Work-Related Stress and Autonomic Imbalance among Call Center Employees in Japan.
Abstract There is little epidemiological evidence linking subjective stress to objective etiologic indicators. To clarify an association between work-related stress and autonomic nervous function, we examined call center employees (167 males and 371 females) undergoing electrocardiography (ECG) at the time of annual health checkups. The questionnaire was composed of the Brief Job Stress Questionnaire based on the demand-control-support model and the Social Readjustment Rating Scale including detailed contents of home stress. The Bazett's corrected QT (QTc) interval, QT index, and heart rate were obtained from the ...
Source: The Tohoku Journal of Experimental Medicine - December 24, 2017 Category: Research Authors: Enoki M, Maeda E, Iwata T, Murata K Tags: Tohoku J Exp Med Source Type: research

Lower Incidence of Cervical Intraepithelial Neoplasia among Young Women with Human Papillomavirus Vaccination in Miyagi, Japan.
In this study, incidence of abnormal cytology and histology was examined in terms of HPV vaccination among 5,924 women aged 20 to 24 years in the fiscal year (FY) 2014 and 2015. The total rate of vaccination was 16.9% (1,002/5,924). In case of FY 2015, the rates of vaccination were 59.26%, 49.68%, 11.97%, 9.08%, and 4.58% in those aged 20, 21, 22, 23, and 24 years old, respectively. The rates of high-grade squamous intraepithelial lesion (HSIL) or worse were 0.20% (2/1,002) in women with HPV vaccination and 1.14% (56/4,922) in those without HPV vaccination, indicating a significant reduction of 82.46% with vaccination (P
Source: The Tohoku Journal of Experimental Medicine - December 24, 2017 Category: Research Authors: Ozawa N, Ito K, Tase T, Shibuya D, Metoki H, Yaegashi N Tags: Tohoku J Exp Med Source Type: research

Next Generation Sequencing and Genome-Wide Genotyping Identify the Genetic Causes of Intellectual Disability in Ten Consanguineous Families from Jordan.
In this study, whole exome sequencing (WES) and homozygosity mapping were used to identify the genetic causes of ID in ten families from Jordan. The studied families are characterized by consanguineous marriage and having one or more progeny with ID. Likely disease-causing missense mutations were identified in eight families; four families are due to mutations in genes previously implicated with ID and the other four families are due to mutations in genes that are not previously implicated with ID. The novel genes include: BSN (Protein Basson), PTCHD2 (Protein dispatched homolog 3), DHRS3 (Short-chain dehydrogenase/reducta...
Source: The Tohoku Journal of Experimental Medicine - December 24, 2017 Category: Research Authors: Froukh TJ Tags: Tohoku J Exp Med Source Type: research