Durable Remission of Chemotherapy-Refractory Myeloid Sarcoma by Azacitidine
In this report, we presented an 84-year-old female patient with isolated myeloid sarcoma which progressed to myelodysplastic syndrome and systemic myeloid sarcoma despite various types of conventional anti-leukemic chemotherapies. However, the patient got a durable partial response by the monotherapy of azacitidine, a hypomethylating agent. She received thirteen courses of azacitidine therapy without progression. We discuss the possibility that hypomethylating agents are the novel effective and feasible therapeutic options for myeloid sarcoma, even in cases refractory to or relapsed after intensive systemic treatment. We a...
Source: The Tohoku Journal of Experimental Medicine - June 21, 2021 Category: Research Authors: Haruya Okamoto Yuri Kamitsuji Yukiko Komori Nana Sasaki Yasuhiko Tsutsumi Akihiro Miyashita Taku Tsukamoto Shinsuke Mizutani Yuji Shimura Tsutomu Kobayashi Nobuhiko Uoshima Junya Kuroda Source Type: research

Preoperative Endovascular Embolization in an Easily Bleeding Respiratory Epithelial Adenomatoid Hamartoma of the Olfactory Cleft: A Case Report
In conclusion, accurate preoperative diagnosis and proper preoperative interventions such as embolization are needed for safe and adequate treatment of REAHs that have an abundant blood flow.PMID:34148919 | DOI:10.1620/tjem.254.107 (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - June 21, 2021 Category: Research Authors: Jun Suzuki Hiroki Tozuka Tomotaka Hemmi Hiroyuki Ikushima Tomohiko Ishikawa Yohei Morishita Kazuhiro Nomura Mitsuru Sugawara Yukio Katori Source Type: research

Durable Remission of Chemotherapy-Refractory Myeloid Sarcoma by Azacitidine
In this report, we presented an 84-year-old female patient with isolated myeloid sarcoma which progressed to myelodysplastic syndrome and systemic myeloid sarcoma despite various types of conventional anti-leukemic chemotherapies. However, the patient got a durable partial response by the monotherapy of azacitidine, a hypomethylating agent. She received thirteen courses of azacitidine therapy without progression. We discuss the possibility that hypomethylating agents are the novel effective and feasible therapeutic options for myeloid sarcoma, even in cases refractory to or relapsed after intensive systemic treatment. We a...
Source: The Tohoku Journal of Experimental Medicine - June 21, 2021 Category: Research Authors: Haruya Okamoto Yuri Kamitsuji Yukiko Komori Nana Sasaki Yasuhiko Tsutsumi Akihiro Miyashita Taku Tsukamoto Shinsuke Mizutani Yuji Shimura Tsutomu Kobayashi Nobuhiko Uoshima Junya Kuroda Source Type: research

Preoperative Endovascular Embolization in an Easily Bleeding Respiratory Epithelial Adenomatoid Hamartoma of the Olfactory Cleft: A Case Report
In conclusion, accurate preoperative diagnosis and proper preoperative interventions such as embolization are needed for safe and adequate treatment of REAHs that have an abundant blood flow.PMID:34148919 | DOI:10.1620/tjem.254.107 (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - June 21, 2021 Category: Research Authors: Jun Suzuki Hiroki Tozuka Tomotaka Hemmi Hiroyuki Ikushima Tomohiko Ishikawa Yohei Morishita Kazuhiro Nomura Mitsuru Sugawara Yukio Katori Source Type: research

Durable Remission of Chemotherapy-Refractory Myeloid Sarcoma by Azacitidine
In this report, we presented an 84-year-old female patient with isolated myeloid sarcoma which progressed to myelodysplastic syndrome and systemic myeloid sarcoma despite various types of conventional anti-leukemic chemotherapies. However, the patient got a durable partial response by the monotherapy of azacitidine, a hypomethylating agent. She received thirteen courses of azacitidine therapy without progression. We discuss the possibility that hypomethylating agents are the novel effective and feasible therapeutic options for myeloid sarcoma, even in cases refractory to or relapsed after intensive systemic treatment. We a...
Source: The Tohoku Journal of Experimental Medicine - June 21, 2021 Category: Research Authors: Haruya Okamoto Yuri Kamitsuji Yukiko Komori Nana Sasaki Yasuhiko Tsutsumi Akihiro Miyashita Taku Tsukamoto Shinsuke Mizutani Yuji Shimura Tsutomu Kobayashi Nobuhiko Uoshima Junya Kuroda Source Type: research

Preoperative Endovascular Embolization in an Easily Bleeding Respiratory Epithelial Adenomatoid Hamartoma of the Olfactory Cleft: A Case Report
In conclusion, accurate preoperative diagnosis and proper preoperative interventions such as embolization are needed for safe and adequate treatment of REAHs that have an abundant blood flow.PMID:34148919 | DOI:10.1620/tjem.254.107 (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - June 21, 2021 Category: Research Authors: Jun Suzuki Hiroki Tozuka Tomotaka Hemmi Hiroyuki Ikushima Tomohiko Ishikawa Yohei Morishita Kazuhiro Nomura Mitsuru Sugawara Yukio Katori Source Type: research

Treatment of COVID-19-Related Olfactory Disorder Promoted by Kakkontokasenkyushin'i: A Case Series
Tohoku J Exp Med. 2021;254(2):71-80. doi: 10.1620/tjem.254.71.ABSTRACTOlfactory disorders are one of the characteristic symptoms of the coronavirus disease of 2019 (COVID-19), which causes infection and inflammation of the upper and lower respiratory tract. To our knowledge, there are no treatments for COVID-19-related olfactory disorder. Here, we report five olfactory disorder cases in COVID-19, treated using the Japanese traditional (Kampo) medicine, kakkontokasenkyushin'i. We treated five patients with mild COVID-19 at an isolation facility using Kampo medicine, depending on their symptoms. Patients with the olfactory d...
Source: The Tohoku Journal of Experimental Medicine - June 10, 2021 Category: Research Authors: Shin Takayama Ryutaro Arita Rie Ono Natsumi Saito Satoko Suzuki Akiko Kikuchi Minoru Ohsawa Yasunori Tadano Tetsuya Akaishi Junichi Tanaka Takeshi Kanno Michiaki Abe Ko Onodera Tadashi Ishii Source Type: research

Ambient Temperature and Cardiorenal Connection in Elderly Patients with Stable Heart Failure
Tohoku J Exp Med. 2021;254(2):81-87. doi: 10.1620/tjem.254.81.ABSTRACTHeart failure increases among the elderly; however, the influence of ambient temperature on cardiorenal function has not been well investigated. Patients (n = 110, mean age 82.9 years, 43 males) with stable heart failure and creatinine
Source: The Tohoku Journal of Experimental Medicine - June 10, 2021 Category: Research Authors: Tomoko Ichiki Shigenobu Inami Kenta Yamada Akio Kawamura Source Type: research

Treatment of COVID-19-Related Olfactory Disorder Promoted by Kakkontokasenkyushin'i: A Case Series
Tohoku J Exp Med. 2021;254(2):71-80. doi: 10.1620/tjem.254.71.ABSTRACTOlfactory disorders are one of the characteristic symptoms of the coronavirus disease of 2019 (COVID-19), which causes infection and inflammation of the upper and lower respiratory tract. To our knowledge, there are no treatments for COVID-19-related olfactory disorder. Here, we report five olfactory disorder cases in COVID-19, treated using the Japanese traditional (Kampo) medicine, kakkontokasenkyushin'i. We treated five patients with mild COVID-19 at an isolation facility using Kampo medicine, depending on their symptoms. Patients with the olfactory d...
Source: The Tohoku Journal of Experimental Medicine - June 10, 2021 Category: Research Authors: Shin Takayama Ryutaro Arita Rie Ono Natsumi Saito Satoko Suzuki Akiko Kikuchi Minoru Ohsawa Yasunori Tadano Tetsuya Akaishi Junichi Tanaka Takeshi Kanno Michiaki Abe Ko Onodera Tadashi Ishii Source Type: research

Ambient Temperature and Cardiorenal Connection in Elderly Patients with Stable Heart Failure
Tohoku J Exp Med. 2021;254(2):81-87. doi: 10.1620/tjem.254.81.ABSTRACTHeart failure increases among the elderly; however, the influence of ambient temperature on cardiorenal function has not been well investigated. Patients (n = 110, mean age 82.9 years, 43 males) with stable heart failure and creatinine
Source: The Tohoku Journal of Experimental Medicine - June 10, 2021 Category: Research Authors: Tomoko Ichiki Shigenobu Inami Kenta Yamada Akio Kawamura Source Type: research

Treatment of COVID-19-Related Olfactory Disorder Promoted by Kakkontokasenkyushin'i: A Case Series
Tohoku J Exp Med. 2021;254(2):71-80. doi: 10.1620/tjem.254.71.ABSTRACTOlfactory disorders are one of the characteristic symptoms of the coronavirus disease of 2019 (COVID-19), which causes infection and inflammation of the upper and lower respiratory tract. To our knowledge, there are no treatments for COVID-19-related olfactory disorder. Here, we report five olfactory disorder cases in COVID-19, treated using the Japanese traditional (Kampo) medicine, kakkontokasenkyushin'i. We treated five patients with mild COVID-19 at an isolation facility using Kampo medicine, depending on their symptoms. Patients with the olfactory d...
Source: The Tohoku Journal of Experimental Medicine - June 10, 2021 Category: Research Authors: Shin Takayama Ryutaro Arita Rie Ono Natsumi Saito Satoko Suzuki Akiko Kikuchi Minoru Ohsawa Yasunori Tadano Tetsuya Akaishi Junichi Tanaka Takeshi Kanno Michiaki Abe Ko Onodera Tadashi Ishii Source Type: research

Ambient Temperature and Cardiorenal Connection in Elderly Patients with Stable Heart Failure
Tohoku J Exp Med. 2021;254(2):81-87. doi: 10.1620/tjem.254.81.ABSTRACTHeart failure increases among the elderly; however, the influence of ambient temperature on cardiorenal function has not been well investigated. Patients (n = 110, mean age 82.9 years, 43 males) with stable heart failure and creatinine
Source: The Tohoku Journal of Experimental Medicine - June 10, 2021 Category: Research Authors: Tomoko Ichiki Shigenobu Inami Kenta Yamada Akio Kawamura Source Type: research

Treatment of COVID-19-Related Olfactory Disorder Promoted by Kakkontokasenkyushin'i: A Case Series
Tohoku J Exp Med. 2021;254(2):71-80. doi: 10.1620/tjem.254.71.ABSTRACTOlfactory disorders are one of the characteristic symptoms of the coronavirus disease of 2019 (COVID-19), which causes infection and inflammation of the upper and lower respiratory tract. To our knowledge, there are no treatments for COVID-19-related olfactory disorder. Here, we report five olfactory disorder cases in COVID-19, treated using the Japanese traditional (Kampo) medicine, kakkontokasenkyushin'i. We treated five patients with mild COVID-19 at an isolation facility using Kampo medicine, depending on their symptoms. Patients with the olfactory d...
Source: The Tohoku Journal of Experimental Medicine - June 10, 2021 Category: Research Authors: Shin Takayama Ryutaro Arita Rie Ono Natsumi Saito Satoko Suzuki Akiko Kikuchi Minoru Ohsawa Yasunori Tadano Tetsuya Akaishi Junichi Tanaka Takeshi Kanno Michiaki Abe Ko Onodera Tadashi Ishii Source Type: research

Ambient Temperature and Cardiorenal Connection in Elderly Patients with Stable Heart Failure
Tohoku J Exp Med. 2021;254(2):81-87. doi: 10.1620/tjem.254.81.ABSTRACTHeart failure increases among the elderly; however, the influence of ambient temperature on cardiorenal function has not been well investigated. Patients (n = 110, mean age 82.9 years, 43 males) with stable heart failure and creatinine
Source: The Tohoku Journal of Experimental Medicine - June 10, 2021 Category: Research Authors: Tomoko Ichiki Shigenobu Inami Kenta Yamada Akio Kawamura Source Type: research

Treatment of COVID-19-Related Olfactory Disorder Promoted by Kakkontokasenkyushin'i: A Case Series
Tohoku J Exp Med. 2021;254(2):71-80. doi: 10.1620/tjem.254.71.ABSTRACTOlfactory disorders are one of the characteristic symptoms of the coronavirus disease of 2019 (COVID-19), which causes infection and inflammation of the upper and lower respiratory tract. To our knowledge, there are no treatments for COVID-19-related olfactory disorder. Here, we report five olfactory disorder cases in COVID-19, treated using the Japanese traditional (Kampo) medicine, kakkontokasenkyushin'i. We treated five patients with mild COVID-19 at an isolation facility using Kampo medicine, depending on their symptoms. Patients with the olfactory d...
Source: The Tohoku Journal of Experimental Medicine - June 10, 2021 Category: Research Authors: Shin Takayama Ryutaro Arita Rie Ono Natsumi Saito Satoko Suzuki Akiko Kikuchi Minoru Ohsawa Yasunori Tadano Tetsuya Akaishi Junichi Tanaka Takeshi Kanno Michiaki Abe Ko Onodera Tadashi Ishii Source Type: research

Ambient Temperature and Cardiorenal Connection in Elderly Patients with Stable Heart Failure
Tohoku J Exp Med. 2021;254(2):81-87. doi: 10.1620/tjem.254.81.ABSTRACTHeart failure increases among the elderly; however, the influence of ambient temperature on cardiorenal function has not been well investigated. Patients (n = 110, mean age 82.9 years, 43 males) with stable heart failure and creatinine
Source: The Tohoku Journal of Experimental Medicine - June 10, 2021 Category: Research Authors: Tomoko Ichiki Shigenobu Inami Kenta Yamada Akio Kawamura Source Type: research

Treatment of COVID-19-Related Olfactory Disorder Promoted by Kakkontokasenkyushin'i: A Case Series
Tohoku J Exp Med. 2021;254(2):71-80. doi: 10.1620/tjem.254.71.ABSTRACTOlfactory disorders are one of the characteristic symptoms of the coronavirus disease of 2019 (COVID-19), which causes infection and inflammation of the upper and lower respiratory tract. To our knowledge, there are no treatments for COVID-19-related olfactory disorder. Here, we report five olfactory disorder cases in COVID-19, treated using the Japanese traditional (Kampo) medicine, kakkontokasenkyushin'i. We treated five patients with mild COVID-19 at an isolation facility using Kampo medicine, depending on their symptoms. Patients with the olfactory d...
Source: The Tohoku Journal of Experimental Medicine - June 10, 2021 Category: Research Authors: Shin Takayama Ryutaro Arita Rie Ono Natsumi Saito Satoko Suzuki Akiko Kikuchi Minoru Ohsawa Yasunori Tadano Tetsuya Akaishi Junichi Tanaka Takeshi Kanno Michiaki Abe Ko Onodera Tadashi Ishii Source Type: research

Ambient Temperature and Cardiorenal Connection in Elderly Patients with Stable Heart Failure
Tohoku J Exp Med. 2021;254(2):81-87. doi: 10.1620/tjem.254.81.ABSTRACTHeart failure increases among the elderly; however, the influence of ambient temperature on cardiorenal function has not been well investigated. Patients (n = 110, mean age 82.9 years, 43 males) with stable heart failure and creatinine
Source: The Tohoku Journal of Experimental Medicine - June 10, 2021 Category: Research Authors: Tomoko Ichiki Shigenobu Inami Kenta Yamada Akio Kawamura Source Type: research

Treatment of COVID-19-Related Olfactory Disorder Promoted by Kakkontokasenkyushin'i: A Case Series
Tohoku J Exp Med. 2021;254(2):71-80. doi: 10.1620/tjem.254.71.ABSTRACTOlfactory disorders are one of the characteristic symptoms of the coronavirus disease of 2019 (COVID-19), which causes infection and inflammation of the upper and lower respiratory tract. To our knowledge, there are no treatments for COVID-19-related olfactory disorder. Here, we report five olfactory disorder cases in COVID-19, treated using the Japanese traditional (Kampo) medicine, kakkontokasenkyushin'i. We treated five patients with mild COVID-19 at an isolation facility using Kampo medicine, depending on their symptoms. Patients with the olfactory d...
Source: The Tohoku Journal of Experimental Medicine - June 10, 2021 Category: Research Authors: Shin Takayama Ryutaro Arita Rie Ono Natsumi Saito Satoko Suzuki Akiko Kikuchi Minoru Ohsawa Yasunori Tadano Tetsuya Akaishi Junichi Tanaka Takeshi Kanno Michiaki Abe Ko Onodera Tadashi Ishii Source Type: research

Ambient Temperature and Cardiorenal Connection in Elderly Patients with Stable Heart Failure
Tohoku J Exp Med. 2021;254(2):81-87. doi: 10.1620/tjem.254.81.ABSTRACTHeart failure increases among the elderly; however, the influence of ambient temperature on cardiorenal function has not been well investigated. Patients (n = 110, mean age 82.9 years, 43 males) with stable heart failure and creatinine
Source: The Tohoku Journal of Experimental Medicine - June 10, 2021 Category: Research Authors: Tomoko Ichiki Shigenobu Inami Kenta Yamada Akio Kawamura Source Type: research

Treatment of COVID-19-Related Olfactory Disorder Promoted by Kakkontokasenkyushin'i: A Case Series
Tohoku J Exp Med. 2021;254(2):71-80. doi: 10.1620/tjem.254.71.ABSTRACTOlfactory disorders are one of the characteristic symptoms of the coronavirus disease of 2019 (COVID-19), which causes infection and inflammation of the upper and lower respiratory tract. To our knowledge, there are no treatments for COVID-19-related olfactory disorder. Here, we report five olfactory disorder cases in COVID-19, treated using the Japanese traditional (Kampo) medicine, kakkontokasenkyushin'i. We treated five patients with mild COVID-19 at an isolation facility using Kampo medicine, depending on their symptoms. Patients with the olfactory d...
Source: The Tohoku Journal of Experimental Medicine - June 10, 2021 Category: Research Authors: Shin Takayama Ryutaro Arita Rie Ono Natsumi Saito Satoko Suzuki Akiko Kikuchi Minoru Ohsawa Yasunori Tadano Tetsuya Akaishi Junichi Tanaka Takeshi Kanno Michiaki Abe Ko Onodera Tadashi Ishii Source Type: research

Ambient Temperature and Cardiorenal Connection in Elderly Patients with Stable Heart Failure
Tohoku J Exp Med. 2021;254(2):81-87. doi: 10.1620/tjem.254.81.ABSTRACTHeart failure increases among the elderly; however, the influence of ambient temperature on cardiorenal function has not been well investigated. Patients (n = 110, mean age 82.9 years, 43 males) with stable heart failure and creatinine
Source: The Tohoku Journal of Experimental Medicine - June 10, 2021 Category: Research Authors: Tomoko Ichiki Shigenobu Inami Kenta Yamada Akio Kawamura Source Type: research

miR-4270 Modulates the Irradiation-Sensitivity of Nasopharyngeal Carcinoma Cells through Modulation of p53 in Vivo
In conclusion, this study first reports that miR-4270 is lower in the radio-sensitive patients and modulated the irradiation-sensitivity of nasopharyngeal carcinoma cells through modulation of p53 in vivo.PMID:34078755 | DOI:10.1620/tjem.254.63 (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - June 3, 2021 Category: Research Authors: Wenwei Hao Yongping Zhu Haowei Wang Ying Guo Source Type: research

miR-4270 Modulates the Irradiation-Sensitivity of Nasopharyngeal Carcinoma Cells through Modulation of p53 in Vivo
In conclusion, this study first reports that miR-4270 is lower in the radio-sensitive patients and modulated the irradiation-sensitivity of nasopharyngeal carcinoma cells through modulation of p53 in vivo.PMID:34078755 | DOI:10.1620/tjem.254.63 (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - June 3, 2021 Category: Research Authors: Wenwei Hao Yongping Zhu Haowei Wang Ying Guo Source Type: research

miR-4270 Modulates the Irradiation-Sensitivity of Nasopharyngeal Carcinoma Cells through Modulation of p53 in Vivo
In conclusion, this study first reports that miR-4270 is lower in the radio-sensitive patients and modulated the irradiation-sensitivity of nasopharyngeal carcinoma cells through modulation of p53 in vivo.PMID:34078755 | DOI:10.1620/tjem.254.63 (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - June 3, 2021 Category: Research Authors: Wenwei Hao Yongping Zhu Haowei Wang Ying Guo Source Type: research

miR-4270 Modulates the Irradiation-Sensitivity of Nasopharyngeal Carcinoma Cells through Modulation of p53 in Vivo
In conclusion, this study first reports that miR-4270 is lower in the radio-sensitive patients and modulated the irradiation-sensitivity of nasopharyngeal carcinoma cells through modulation of p53 in vivo.PMID:34078755 | DOI:10.1620/tjem.254.63 (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - June 3, 2021 Category: Research Authors: Wenwei Hao Yongping Zhu Haowei Wang Ying Guo Source Type: research

miR-4270 Modulates the Irradiation-Sensitivity of Nasopharyngeal Carcinoma Cells through Modulation of p53 in Vivo
In conclusion, this study first reports that miR-4270 is lower in the radio-sensitive patients and modulated the irradiation-sensitivity of nasopharyngeal carcinoma cells through modulation of p53 in vivo.PMID:34078755 | DOI:10.1620/tjem.254.63 (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - June 3, 2021 Category: Research Authors: Wenwei Hao Yongping Zhu Haowei Wang Ying Guo Source Type: research

miR-4270 Modulates the Irradiation-Sensitivity of Nasopharyngeal Carcinoma Cells through Modulation of p53 in Vivo
In conclusion, this study first reports that miR-4270 is lower in the radio-sensitive patients and modulated the irradiation-sensitivity of nasopharyngeal carcinoma cells through modulation of p53 in vivo.PMID:34078755 | DOI:10.1620/tjem.254.63 (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - June 3, 2021 Category: Research Authors: Wenwei Hao Yongping Zhu Haowei Wang Ying Guo Source Type: research

Phase II Study of the Reuse of Trastuzumab with Docetaxel beyond Progression after First-Line Treatment in Second-Line Treatment for Unresectable, Metastatic Gastric Cancer (T-CORE1203)
Tohoku J Exp Med. 2021;254(1):49-55. doi: 10.1620/tjem.254.49.ABSTRACTWhether trastuzumab use beyond disease progression is beneficial in second-line treatment for patients with unresectable human epidermal growth factor receptor 2 (HER2)-positive gastric cancer remains to be elucidated. We conducted this phase II study to assess whether trastuzumab plus docetaxel was effective for patients with previously treated advanced HER2-positive gastric cancer. This trial was a single-arm, open-label, multicenter, phase II study, conducted by Tohoku Clinical Oncology Research and Education Society (T-CORE). Patients aged 20 years o...
Source: The Tohoku Journal of Experimental Medicine - May 31, 2021 Category: Research Authors: Masanobu Takahashi Yasuhiro Sakamoto Kazunori Otsuka Mariko Kanbe Hisatsugu Ohori Yoshiaki Shindo Hiroshi Honda Ken Saijo Kota Ouchi Yasuko Murakawa Hidekazu Takahashi Sadayuki Kawai Yuichi Tanaka Takuhiro Yamaguchi Hideki Shimodaira Takashi Yoshioka Chik Source Type: research

The Effect of Teriparatide for the Treatment of Multiple Spontaneous Clinical Vertebral Fractures after Discontinuation of Denosumab in a Female Patient with Rheumatoid Arthritis: A Case Report
Tohoku J Exp Med. 2021;254(1):57-61. doi: 10.1620/tjem.254.57.ABSTRACTDiscontinuation of denosumab is associated with the risk of rebound in bone turnover and rebound-associated spontaneous clinical vertebral fractures. This case report presents an 86-year-old woman with rheumatoid arthritis who experienced rebound-associated spontaneous clinical vertebral fractures at 9 months after denosumab discontinuation. Following 5-year bisphosphonate treatment, the patient had 9 injections of 60-mg denosumab every 6 months. Because of tooth extraction, denosumab treatment was discontinued, and raloxifene was administered. At 9 mont...
Source: The Tohoku Journal of Experimental Medicine - May 31, 2021 Category: Research Authors: Yu Mori Takuya Izumiyama Naoko Mori Toshimi Aizawa Source Type: research

Phase II Study of the Reuse of Trastuzumab with Docetaxel beyond Progression after First-Line Treatment in Second-Line Treatment for Unresectable, Metastatic Gastric Cancer (T-CORE1203)
Tohoku J Exp Med. 2021;254(1):49-55. doi: 10.1620/tjem.254.49.ABSTRACTWhether trastuzumab use beyond disease progression is beneficial in second-line treatment for patients with unresectable human epidermal growth factor receptor 2 (HER2)-positive gastric cancer remains to be elucidated. We conducted this phase II study to assess whether trastuzumab plus docetaxel was effective for patients with previously treated advanced HER2-positive gastric cancer. This trial was a single-arm, open-label, multicenter, phase II study, conducted by Tohoku Clinical Oncology Research and Education Society (T-CORE). Patients aged 20 years o...
Source: The Tohoku Journal of Experimental Medicine - May 31, 2021 Category: Research Authors: Masanobu Takahashi Yasuhiro Sakamoto Kazunori Otsuka Mariko Kanbe Hisatsugu Ohori Yoshiaki Shindo Hiroshi Honda Ken Saijo Kota Ouchi Yasuko Murakawa Hidekazu Takahashi Sadayuki Kawai Yuichi Tanaka Takuhiro Yamaguchi Hideki Shimodaira Takashi Yoshioka Chik Source Type: research

The Effect of Teriparatide for the Treatment of Multiple Spontaneous Clinical Vertebral Fractures after Discontinuation of Denosumab in a Female Patient with Rheumatoid Arthritis: A Case Report
Tohoku J Exp Med. 2021;254(1):57-61. doi: 10.1620/tjem.254.57.ABSTRACTDiscontinuation of denosumab is associated with the risk of rebound in bone turnover and rebound-associated spontaneous clinical vertebral fractures. This case report presents an 86-year-old woman with rheumatoid arthritis who experienced rebound-associated spontaneous clinical vertebral fractures at 9 months after denosumab discontinuation. Following 5-year bisphosphonate treatment, the patient had 9 injections of 60-mg denosumab every 6 months. Because of tooth extraction, denosumab treatment was discontinued, and raloxifene was administered. At 9 mont...
Source: The Tohoku Journal of Experimental Medicine - May 31, 2021 Category: Research Authors: Yu Mori Takuya Izumiyama Naoko Mori Toshimi Aizawa Source Type: research

Phase II Study of the Reuse of Trastuzumab with Docetaxel beyond Progression after First-Line Treatment in Second-Line Treatment for Unresectable, Metastatic Gastric Cancer (T-CORE1203)
Tohoku J Exp Med. 2021;254(1):49-55. doi: 10.1620/tjem.254.49.ABSTRACTWhether trastuzumab use beyond disease progression is beneficial in second-line treatment for patients with unresectable human epidermal growth factor receptor 2 (HER2)-positive gastric cancer remains to be elucidated. We conducted this phase II study to assess whether trastuzumab plus docetaxel was effective for patients with previously treated advanced HER2-positive gastric cancer. This trial was a single-arm, open-label, multicenter, phase II study, conducted by Tohoku Clinical Oncology Research and Education Society (T-CORE). Patients aged 20 years o...
Source: The Tohoku Journal of Experimental Medicine - May 31, 2021 Category: Research Authors: Masanobu Takahashi Yasuhiro Sakamoto Kazunori Otsuka Mariko Kanbe Hisatsugu Ohori Yoshiaki Shindo Hiroshi Honda Ken Saijo Kota Ouchi Yasuko Murakawa Hidekazu Takahashi Sadayuki Kawai Yuichi Tanaka Takuhiro Yamaguchi Hideki Shimodaira Takashi Yoshioka Chik Source Type: research

The Effect of Teriparatide for the Treatment of Multiple Spontaneous Clinical Vertebral Fractures after Discontinuation of Denosumab in a Female Patient with Rheumatoid Arthritis: A Case Report
Tohoku J Exp Med. 2021;254(1):57-61. doi: 10.1620/tjem.254.57.ABSTRACTDiscontinuation of denosumab is associated with the risk of rebound in bone turnover and rebound-associated spontaneous clinical vertebral fractures. This case report presents an 86-year-old woman with rheumatoid arthritis who experienced rebound-associated spontaneous clinical vertebral fractures at 9 months after denosumab discontinuation. Following 5-year bisphosphonate treatment, the patient had 9 injections of 60-mg denosumab every 6 months. Because of tooth extraction, denosumab treatment was discontinued, and raloxifene was administered. At 9 mont...
Source: The Tohoku Journal of Experimental Medicine - May 31, 2021 Category: Research Authors: Yu Mori Takuya Izumiyama Naoko Mori Toshimi Aizawa Source Type: research

The Prevalence of Binge Drinking and Alcohol-Related Consequences and their Relationship among Japanese College Students
Tohoku J Exp Med. 2021;254(1):41-47. doi: 10.1620/tjem.254.41.ABSTRACTBinge drinking is a common and risky behavior among college students. In Japan, however, research on the prevalence of binge drinking and alcohol-related consequences, and the relationship between them, is currently scant. The aim of this study is to examine the status of binge drinking and alcohol-related problems, and the relationship between them, among Japanese college students. We conducted a cross-sectional survey of college students who participated in a health seminar or lecture including alcohol-related contents from December 2018 to January 201...
Source: The Tohoku Journal of Experimental Medicine - May 27, 2021 Category: Research Authors: Kyoko Kawaida Hisashi Yoshimoto Nobuaki Morita Yasukazu Ogai Tamaki Saito Source Type: research

The Prevalence of Binge Drinking and Alcohol-Related Consequences and their Relationship among Japanese College Students
Tohoku J Exp Med. 2021;254(1):41-47. doi: 10.1620/tjem.254.41.ABSTRACTBinge drinking is a common and risky behavior among college students. In Japan, however, research on the prevalence of binge drinking and alcohol-related consequences, and the relationship between them, is currently scant. The aim of this study is to examine the status of binge drinking and alcohol-related problems, and the relationship between them, among Japanese college students. We conducted a cross-sectional survey of college students who participated in a health seminar or lecture including alcohol-related contents from December 2018 to January 201...
Source: The Tohoku Journal of Experimental Medicine - May 27, 2021 Category: Research Authors: Kyoko Kawaida Hisashi Yoshimoto Nobuaki Morita Yasukazu Ogai Tamaki Saito Source Type: research

The Prevalence of Binge Drinking and Alcohol-Related Consequences and their Relationship among Japanese College Students
Tohoku J Exp Med. 2021;254(1):41-47. doi: 10.1620/tjem.254.41.ABSTRACTBinge drinking is a common and risky behavior among college students. In Japan, however, research on the prevalence of binge drinking and alcohol-related consequences, and the relationship between them, is currently scant. The aim of this study is to examine the status of binge drinking and alcohol-related problems, and the relationship between them, among Japanese college students. We conducted a cross-sectional survey of college students who participated in a health seminar or lecture including alcohol-related contents from December 2018 to January 201...
Source: The Tohoku Journal of Experimental Medicine - May 27, 2021 Category: Research Authors: Kyoko Kawaida Hisashi Yoshimoto Nobuaki Morita Yasukazu Ogai Tamaki Saito Source Type: research

The Prevalence of Binge Drinking and Alcohol-Related Consequences and their Relationship among Japanese College Students
Tohoku J Exp Med. 2021;254(1):41-47. doi: 10.1620/tjem.254.41.ABSTRACTBinge drinking is a common and risky behavior among college students. In Japan, however, research on the prevalence of binge drinking and alcohol-related consequences, and the relationship between them, is currently scant. The aim of this study is to examine the status of binge drinking and alcohol-related problems, and the relationship between them, among Japanese college students. We conducted a cross-sectional survey of college students who participated in a health seminar or lecture including alcohol-related contents from December 2018 to January 201...
Source: The Tohoku Journal of Experimental Medicine - May 27, 2021 Category: Research Authors: Kyoko Kawaida Hisashi Yoshimoto Nobuaki Morita Yasukazu Ogai Tamaki Saito Source Type: research

Characteristics of Home-Visit Nursing Stations that Accept Children Requiring Long-Term Medical Care after Discharge from Neonatal Intensive Care Unit
Tohoku J Exp Med. 2021;254(1):25-31. doi: 10.1620/tjem.254.25.ABSTRACTMany cultures are witnessing high-risk births due to the increasing trend of delayed childbearing. This has resulted in a higher proportion of children requiring long-term medical care (CLTM). The number of home-visit nursing stations available for pediatric patients should increase to provide care for CLTM at home. Through a questionnaire-based cross-sectional survey of 338 home-visit nursing station managers, this study aimed to identify the determinants of the acceptance of CLTM by analyzing the characteristics of the stations, managers, staff, and re...
Source: The Tohoku Journal of Experimental Medicine - May 20, 2021 Category: Research Authors: Yumi Nomoto Toyohiko Kodama Source Type: research

Cul4b Promotes Progression of Malignant Cutaneous Melanoma Patients by Regulating CDKN2A
In this study, immunohistochemistry was performed to assess the expression of Cul4b in a consecutive patient cohort. The prognostic role of Cul4b was estimated with univariate and multivariate analysis. Cul4b was knocked down in melanoma cell line to evaluate its role in promoting cell proliferation. The results revealed that Cul4b was highly expressed in some of the cutaneous malignant melanoma patients and high expression of Cul4b was associated with poor melanoma-specific overall survival and poor disease-free survival. Cul4b expression was associated with Breslow categories, Clark level, and Ki67 expression. Univariate...
Source: The Tohoku Journal of Experimental Medicine - May 20, 2021 Category: Research Authors: Chao Zhang Can Cao Xiu-Li Liu Tan Jun Pei Liu Source Type: research

Pathology of Aldosterone Biosynthesis and its Action
Tohoku J Exp Med. 2021;254(1):1-15. doi: 10.1620/tjem.254.1.ABSTRACTAldosterone plays pivotal roles in renin-angiotensin-aldosterone system in order to maintain the equilibrium of liquid volume and electrolyte metabolism. Aldosterone action is mediated by both mineralocorticoid receptor and 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2). Its excessive actions directly induced tissue injuries in its target organs such as myocardial and vascular fibrosis in addition to chronic kidney diseases. Excessive aldosterone actions were also reported to be involved in unbalanced electrolyte metabolism in inflammatory bo...
Source: The Tohoku Journal of Experimental Medicine - May 20, 2021 Category: Research Authors: Xin Gao Yuto Yamazaki Yuta Tezuka Kei Omata Yoshikiyo Ono Ryo Morimoto Yasuhiro Nakamura Takashi Suzuki Fumitoshi Satoh Hironobu Sasano Source Type: research

Tripartite Motif-Containing 44 is Involved in the Tumorigenesis of Laryngeal Squamous Cell Carcinoma, and its Expression is Downregulated by Nuciferine
In conclusion, this study indicated that inhibiting TRIM44 would be a useful strategy for the treatment of laryngeal squamous cell carcinoma, and nuciferine could be a potential chemical applicated in the therapy of laryngeal squamous cell carcinoma.PMID:34011804 | DOI:10.1620/tjem.254.17 (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - May 20, 2021 Category: Research Authors: Qing-Hua Li Li-Ping Sui Yun-Hua Zhao Bao-Gang Chen Jian Li Zhi-Hong Ma Zhi-Hong Hu Yan-Li Tang You-Xin Guo Source Type: research

Characteristics of Home-Visit Nursing Stations that Accept Children Requiring Long-Term Medical Care after Discharge from Neonatal Intensive Care Unit
Tohoku J Exp Med. 2021;254(1):25-31. doi: 10.1620/tjem.254.25.ABSTRACTMany cultures are witnessing high-risk births due to the increasing trend of delayed childbearing. This has resulted in a higher proportion of children requiring long-term medical care (CLTM). The number of home-visit nursing stations available for pediatric patients should increase to provide care for CLTM at home. Through a questionnaire-based cross-sectional survey of 338 home-visit nursing station managers, this study aimed to identify the determinants of the acceptance of CLTM by analyzing the characteristics of the stations, managers, staff, and re...
Source: The Tohoku Journal of Experimental Medicine - May 20, 2021 Category: Research Authors: Yumi Nomoto Toyohiko Kodama Source Type: research

Cul4b Promotes Progression of Malignant Cutaneous Melanoma Patients by Regulating CDKN2A
In this study, immunohistochemistry was performed to assess the expression of Cul4b in a consecutive patient cohort. The prognostic role of Cul4b was estimated with univariate and multivariate analysis. Cul4b was knocked down in melanoma cell line to evaluate its role in promoting cell proliferation. The results revealed that Cul4b was highly expressed in some of the cutaneous malignant melanoma patients and high expression of Cul4b was associated with poor melanoma-specific overall survival and poor disease-free survival. Cul4b expression was associated with Breslow categories, Clark level, and Ki67 expression. Univariate...
Source: The Tohoku Journal of Experimental Medicine - May 20, 2021 Category: Research Authors: Chao Zhang Can Cao Xiu-Li Liu Tan Jun Pei Liu Source Type: research

Pathology of Aldosterone Biosynthesis and its Action
Tohoku J Exp Med. 2021;254(1):1-15. doi: 10.1620/tjem.254.1.ABSTRACTAldosterone plays pivotal roles in renin-angiotensin-aldosterone system in order to maintain the equilibrium of liquid volume and electrolyte metabolism. Aldosterone action is mediated by both mineralocorticoid receptor and 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2). Its excessive actions directly induced tissue injuries in its target organs such as myocardial and vascular fibrosis in addition to chronic kidney diseases. Excessive aldosterone actions were also reported to be involved in unbalanced electrolyte metabolism in inflammatory bo...
Source: The Tohoku Journal of Experimental Medicine - May 20, 2021 Category: Research Authors: Xin Gao Yuto Yamazaki Yuta Tezuka Kei Omata Yoshikiyo Ono Ryo Morimoto Yasuhiro Nakamura Takashi Suzuki Fumitoshi Satoh Hironobu Sasano Source Type: research

Tripartite Motif-Containing 44 is Involved in the Tumorigenesis of Laryngeal Squamous Cell Carcinoma, and its Expression is Downregulated by Nuciferine
In conclusion, this study indicated that inhibiting TRIM44 would be a useful strategy for the treatment of laryngeal squamous cell carcinoma, and nuciferine could be a potential chemical applicated in the therapy of laryngeal squamous cell carcinoma.PMID:34011804 | DOI:10.1620/tjem.254.17 (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - May 20, 2021 Category: Research Authors: Qing-Hua Li Li-Ping Sui Yun-Hua Zhao Bao-Gang Chen Jian Li Zhi-Hong Ma Zhi-Hong Hu Yan-Li Tang You-Xin Guo Source Type: research

Characteristics of Home-Visit Nursing Stations that Accept Children Requiring Long-Term Medical Care after Discharge from Neonatal Intensive Care Unit
Tohoku J Exp Med. 2021;254(1):25-31. doi: 10.1620/tjem.254.25.ABSTRACTMany cultures are witnessing high-risk births due to the increasing trend of delayed childbearing. This has resulted in a higher proportion of children requiring long-term medical care (CLTM). The number of home-visit nursing stations available for pediatric patients should increase to provide care for CLTM at home. Through a questionnaire-based cross-sectional survey of 338 home-visit nursing station managers, this study aimed to identify the determinants of the acceptance of CLTM by analyzing the characteristics of the stations, managers, staff, and re...
Source: The Tohoku Journal of Experimental Medicine - May 20, 2021 Category: Research Authors: Yumi Nomoto Toyohiko Kodama Source Type: research

Cul4b Promotes Progression of Malignant Cutaneous Melanoma Patients by Regulating CDKN2A
In this study, immunohistochemistry was performed to assess the expression of Cul4b in a consecutive patient cohort. The prognostic role of Cul4b was estimated with univariate and multivariate analysis. Cul4b was knocked down in melanoma cell line to evaluate its role in promoting cell proliferation. The results revealed that Cul4b was highly expressed in some of the cutaneous malignant melanoma patients and high expression of Cul4b was associated with poor melanoma-specific overall survival and poor disease-free survival. Cul4b expression was associated with Breslow categories, Clark level, and Ki67 expression. Univariate...
Source: The Tohoku Journal of Experimental Medicine - May 20, 2021 Category: Research Authors: Chao Zhang Can Cao Xiu-Li Liu Tan Jun Pei Liu Source Type: research

Pathology of Aldosterone Biosynthesis and its Action
Tohoku J Exp Med. 2021;254(1):1-15. doi: 10.1620/tjem.254.1.ABSTRACTAldosterone plays pivotal roles in renin-angiotensin-aldosterone system in order to maintain the equilibrium of liquid volume and electrolyte metabolism. Aldosterone action is mediated by both mineralocorticoid receptor and 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2). Its excessive actions directly induced tissue injuries in its target organs such as myocardial and vascular fibrosis in addition to chronic kidney diseases. Excessive aldosterone actions were also reported to be involved in unbalanced electrolyte metabolism in inflammatory bo...
Source: The Tohoku Journal of Experimental Medicine - May 20, 2021 Category: Research Authors: Xin Gao Yuto Yamazaki Yuta Tezuka Kei Omata Yoshikiyo Ono Ryo Morimoto Yasuhiro Nakamura Takashi Suzuki Fumitoshi Satoh Hironobu Sasano Source Type: research

Tripartite Motif-Containing 44 is Involved in the Tumorigenesis of Laryngeal Squamous Cell Carcinoma, and its Expression is Downregulated by Nuciferine
In conclusion, this study indicated that inhibiting TRIM44 would be a useful strategy for the treatment of laryngeal squamous cell carcinoma, and nuciferine could be a potential chemical applicated in the therapy of laryngeal squamous cell carcinoma.PMID:34011804 | DOI:10.1620/tjem.254.17 (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - May 20, 2021 Category: Research Authors: Qing-Hua Li Li-Ping Sui Yun-Hua Zhao Bao-Gang Chen Jian Li Zhi-Hong Ma Zhi-Hong Hu Yan-Li Tang You-Xin Guo Source Type: research