Age-Specific Determinants of Brachial-Ankle Pulse Wave Velocity among Male Japanese Workers
In conclusion, hemodynamics significantly affected baPWV across all ages, while smoking index, total physical activity, body mass index, and skeletal muscle index affected baPWV depending on the age group. Thus, age-related strategies should be established for alleviating baPWV increase.PMID:33627577 | DOI:10.1620/tjem.253.135 (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - February 25, 2021 Category: Research Authors: Atsushi Inomoto Junko Deguchi Rika Fukuda Takamichi Yotsumoto Toshihiro Toyonaga Source Type: research

Incidence and Relapse Triggers of Childhood Idiopathic Nephrotic Syndrome between 2006 and 2016: A Population-Based Study in Fukushima, Japan
Tohoku J Exp Med. 2021;253(2):125-134. doi: 10.1620/tjem.253.125.ABSTRACTChildhood idiopathic nephrotic syndrome (NS) is defined by proteinuria and hypoproteinemia. The incidence of childhood idiopathic NS varies with age, race, residential areas, and social conditions. In Japan, its incidence was estimated to be 6.49 cases/100,000 children. Our study aimed to investigate the incidence, characteristics, and rate of relapse of idiopathic NS in Fukushima between 2006 and 2016. Overall, 158 children aged from 6 months to 15 years old (65.8% male) developed idiopathic NS (median age at onset, 5.3 years). The peak age at onset ...
Source: The Tohoku Journal of Experimental Medicine - February 22, 2021 Category: Research Authors: Yohei Kume Yukihiko Kawasaki Kazuhide Suyama Ryo Maeda Yui Takahashi Masato Hoshino Shigeo Suzuki Masaki Mitomo Ruriko Nozawa Yoshiyuki Namai Hiroko Sakuma Masatoshi Kaneko Shinichi Oda Hiromichi Murai Shuto Kanno Katustoshi Nagasawa Masaki Ito Hoshiro Su Source Type: research

Incidence and Relapse Triggers of Childhood Idiopathic Nephrotic Syndrome between 2006 and 2016: A Population-Based Study in Fukushima, Japan
Tohoku J Exp Med. 2021;253(2):125-134. doi: 10.1620/tjem.253.125.ABSTRACTChildhood idiopathic nephrotic syndrome (NS) is defined by proteinuria and hypoproteinemia. The incidence of childhood idiopathic NS varies with age, race, residential areas, and social conditions. In Japan, its incidence was estimated to be 6.49 cases/100,000 children. Our study aimed to investigate the incidence, characteristics, and rate of relapse of idiopathic NS in Fukushima between 2006 and 2016. Overall, 158 children aged from 6 months to 15 years old (65.8% male) developed idiopathic NS (median age at onset, 5.3 years). The peak age at onset ...
Source: The Tohoku Journal of Experimental Medicine - February 22, 2021 Category: Research Authors: Yohei Kume Yukihiko Kawasaki Kazuhide Suyama Ryo Maeda Yui Takahashi Masato Hoshino Shigeo Suzuki Masaki Mitomo Ruriko Nozawa Yoshiyuki Namai Hiroko Sakuma Masatoshi Kaneko Shinichi Oda Hiromichi Murai Shuto Kanno Katustoshi Nagasawa Masaki Ito Hoshiro Su Source Type: research

Social Factors for Leading to Life Satisfaction among Residents with Developmental Disorders in Fukushima Prefecture.
Abstract A developmental disorder is condition in which a person has deficiency in either physical, learning, language, or behavior, and people with developmental disorders often experience difficulties in their social lives. In Japan, no systematic surveys of developmental disorders targeting local residents have been reported, including working-age. Hence, we aimed to estimate the prevalence and determine the psychosocial factors associated with life satisfaction and psychological distress in the Fukushima prefecture. We conducted an Internet questionnaire survey among 4,030 residents (2,136 men and 1,894 women)...
Source: The Tohoku Journal of Experimental Medicine - February 21, 2021 Category: Research Authors: Yoshida T, Eguchi E, Mashiko H, Ohira T Tags: Tohoku J Exp Med Source Type: research

Effectiveness of Ursodeoxycholic Acid in the Treatment of Primary Sclerosing Cholangitis with Ulcerative Colitis: A Pediatric Case.
Abstract Primary sclerosing cholangitis is a rare disease with poor prognosis that potentially leads to liver cirrhosis and is often complicated by inflammatory bowel disease. Although ursodeoxycholic acid is the most commonly used drug to treat primary sclerosing cholangitis, its effectiveness in treating primary sclerosing cholangitis has not yet been established. An 11-year-old girl had a fever, upper and lower abdominal pain, and bloody stools. Colonoscopy revealed ulcerative colitis. She also had elevated hepatobiliary enzyme levels and C-reactive protein levels, indicating cholangitis after starting food int...
Source: The Tohoku Journal of Experimental Medicine - February 10, 2021 Category: Research Authors: Fujita Y, Sugaya T, Inui A, Yoshihara S Tags: Tohoku J Exp Med Source Type: research

High Parity Is an Independent Risk Factor for Tooth Loss in Women: A Community-Based Takahata Study in Japan.
In conclusion, the present study emphasizes the importance of good oral health habits in women, especially, during pregnancy and in the postpartum period, to maintain 20 or more teeth. PMID: 33504756 [PubMed - in process] (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - January 29, 2021 Category: Research Authors: Ishikawa S, Konta T, Susa S, Edamatsu K, Ishizawa K, Togashi H, Nagase S, Ueno Y, Kubota I, Yamashita H, Kayama T, Iino M Tags: Tohoku J Exp Med Source Type: research

Appendicular Skeletal Muscle Mass Correlates with Patient-Reported Outcomes and Physical Performance in Patients with Idiopathic Pulmonary Fibrosis.
In conclusion, assessing ASMI is helpful for the comprehensive care of patients with IPF. PMID: 33473063 [PubMed - in process] (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - January 22, 2021 Category: Research Authors: Ebihara K, Iwanami Y, Yamasaki K, Takemura A, Sato N, Usui Y, Nakamura Y, Kishi K, Homma S, Ebihara S Tags: Tohoku J Exp Med Source Type: research

Curcumin Mitigates Hypertension, Endothelial Dysfunction and Oxidative Stress in Rats with Chronic Exposure to Lead and Cadmium.
Abstract Lead (Pb) and cadmium (Cd) are environmental pollutants and nonessential elements in the body. Both metals induce the development of hypertension which is associated with oxidative stress. Curcumin (CUR) is a polyphenolic compound with strong antioxidant activity. The present study evaluated the effect of CUR on oxidative stress, alteration of vascular responsiveness and hypertension induced by exposure to either Pb, Cd or the combination of Pb and Cd. Male Sprague-Dawley rats were exposed to low level of lead acetate (100 mg/L) and/or cadmium chloride (10 mg/L) in the drinking water for 16 weeks. The con...
Source: The Tohoku Journal of Experimental Medicine - January 22, 2021 Category: Research Authors: Tubsakul A, Sangartit W, Pakdeechote P, Kukongviriyapan V, Apaijit K, Kukongviriyapan U Tags: Tohoku J Exp Med Source Type: research

Toward the Next 100 Years of the Tohoku Journal of Experimental Medicine.
PMID: 33455970 [PubMed - in process] (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - January 21, 2021 Category: Research Authors: Takahashi K Tags: Tohoku J Exp Med Source Type: research

Vascular Endothelial Dysfunction and Autonomic Nervous Hyperactivity among Premenopausal Women with Cold-Sensitivity Constitution (Hiesho).
Abstract The cold-sensitivity constitution (CSC), termed "Hiesho" in Japanese, is a woman-specific cold sense of peripheral sites. The etiology of and criteria for CSC are not yet well established. We defined CSC as temperature gradient> 6˚C between body surface and core, and investigated the autonomic nervous activity by measuring heart rate variability and the vascular endothelial function by determining reactive hyperemia index (RHI) in 43 healthy premenopausal women, aged 18-47 years. Twenty five women had CSC during both the follicular and luteal phases of their menstrual cycles (sustained-CSC g...
Source: The Tohoku Journal of Experimental Medicine - January 21, 2021 Category: Research Authors: Kono K, Abe S, Yamamoto M, Kayashima R, Kaneko K, Sakuma M, Toyoda S, Nakajima T, Inoue T Tags: Tohoku J Exp Med Source Type: research

JNK Pathway-Associated Phosphatase as a Serum Marker for Disease Activity and Treatment Outcome of Juvenile Idiopathic Arthritis.
In conclusion, serum JKAP is a potential biomarker for JIA activity and treatment response to a TNF inhibitor. PMID: 33441511 [PubMed - in process] (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - January 15, 2021 Category: Research Authors: Zhu S, Lv H, Luo Y, Huang Q, Shen J Tags: Tohoku J Exp Med Source Type: research

Predictors of Early and Late Mortality after Endoscopic Resection for Esophageal Squamous Cell Carcinoma.
Abstract In esophageal squamous cell carcinoma (ESCC) comprising 90% of cases with esophageal cancer, endoscopic resection (ER) is recommended for patients with negligible risk of ESCC-related mortality. In fact, a main cause of death in patients underwent ER is not ESCC. We thus aimed to clarify the predictors for early and late mortality among patients underwent ER of ESCC between 2005 and 2018 at our institution. In this retrospective cohort study, we investigated the prognosis and predictors of early and late mortality with the cut-off value of 3 years. We enrolled 407 patients with a median 69 months follow-u...
Source: The Tohoku Journal of Experimental Medicine - January 15, 2021 Category: Research Authors: Ogata Y, Hatta W, Koike T, Saito M, Jin X, Nakagawa K, Kanno T, Uno K, Asano N, Imatani A, Nakamura T, Nakaya N, Masamune A Tags: Tohoku J Exp Med Source Type: research

Urinary Thrombin as a Marker of Glomerular Inflammation Associated with Renal Injury in Type 2 Diabetes.
Abstract Glomerular inflammation is a putative aggravation factor for type 2 diabetic nephropathy and urinary thrombin is a novel marker of glomerular inflammation. To clarify the relationship between glomerular inflammation and progression of the nephropathy, we measured urinary thrombin in 118 patients with type 2 diabetic nephropathy at different stages. To investigate the implications of urinary thrombin in the nephropathy, we compared urinary thrombin with expression of tissue factor, the trigger of blood coagulation activation, in glomeruli and with markers of renal injury (estimated glomerular filtration ra...
Source: The Tohoku Journal of Experimental Medicine - January 15, 2021 Category: Research Authors: Kitamoto Y, Imamura T, Taguma Y, Iwaoka T, Yorinaka H, Arizono K Tags: Tohoku J Exp Med Source Type: research

Eating Fast and Until Full Is Associated with Elevated Alanine Aminotransferase Activity in Japanese Schoolchildren: A Cross-Sectional Study.
In conclusion, "eating fast and eating until full" was associated with elevated ALT in schoolchildren. A sex difference in the association of "eating fast and not eating until full" with elevated ALT was observed. Modifying the behaviors of eating fast and eating until full is important for schoolchildren to prevent ALT elevation. PMID: 33408301 [PubMed - in process] (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - January 9, 2021 Category: Research Authors: Minoura A, Ochiai H, Shirasawa T, Nishimura R, Yoshida R, Azuma M, Hoshino H, Kokaze A Tags: Tohoku J Exp Med Source Type: research

Optimal Cutoff Values of the Alcohol Use Disorders Identification Test and its Short Version for Detecting Excessive Alcohol Use in Japanese College Students.
Abstract Alcohol use disorder is a serious health problem in college students. Alcohol Use Disorders Identification Test (AUDIT) is a 10-item screening tool to assess alcohol consumption, drinking behaviors, and alcohol-related problems. AUDIT-C is a short version of AUDIT, consisting of consumption items 1-3. However, the optimal cutoff values of AUDIT and AUDIT-C for detecting excessive drinking are not available for Japanese college students. The aim of this study was to evaluate the validity of cutoff points of AUDIT and AUDIT-C for detecting moderate drinking, heavy drinking and binge drinking among Japanese ...
Source: The Tohoku Journal of Experimental Medicine - January 9, 2021 Category: Research Authors: Kawaida K, Yoshimoto H, Saito G, Takayashiki A Tags: Tohoku J Exp Med Source Type: research

New-Onset or Exacerbation of Diabetes Mellitus Is a Clue to the Early Diagnosis of Pancreatic Cancer.
Abstract Pancreatic ductal adenocarcinoma (PDAC), which accounts for majority of pancreatic cancers, is one of the most lethal human malignancies. Most patients are diagnosed at an advanced stage after symptom development. Early diagnosis of PDAC in asymptomatic subjects is important to improve prognosis. Diabetes mellitus (DM) is a risk factor for PDAC, and DM, especially new-onset DM, has attracted attentions as a diagnostic clue to PDAC. However, the impact of DM as a diagnostic opportunity on the prognosis of PDAC is unclear. We here retrospectively reviewed 489 PDAC patients and compared the clinical characte...
Source: The Tohoku Journal of Experimental Medicine - December 23, 2020 Category: Research Authors: Takikawa T, Kikuta K, Kume K, Hamada S, Miura S, Yoshida N, Hongo S, Tanaka Y, Matsumoto R, Sano T, Ikeda M, Iseki M, Unno M, Masamune A Tags: Tohoku J Exp Med Source Type: research

Repeatability and Reliability of Home-Based Stool Color Card Screening for Biliary Atresia Based on Results in China and Japan.
This study shows excellent repeatability and reliability of the current digital edition of SCC. PMID: 33342972 [PubMed - in process] (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - December 23, 2020 Category: Research Authors: Gu YH, Zhao JQ, Kong YY, Yang HH, Diao M, Li L, Nomachi S, Tezuka M, Hanai J, Matsui A Tags: Tohoku J Exp Med Source Type: research

Exosomes in Hepatitis B Virus Transmission and Related Immune Response.
Abstract The chronicity of Hepatitis B virus (HBV) infection relates to both viral factors and host factors. HBV could result in persistent infection and even serious liver disease, including chronic hepatitis B (CHB), cirrhosis and hepatocellular carcinoma (HCC). Although the HBV vaccine can effectively prevent HBV infection, chronic HBV infection still endangers human health and results in a large social burden. Moreover, the mechanisms underlying the HBV-mediated imbalance of the immune response and persistent infection are not fully understood. Exosomes are extracellular vesicles (EVs) 40-160 nm in size that a...
Source: The Tohoku Journal of Experimental Medicine - December 5, 2020 Category: Research Authors: Wang J, Cao D, Yang J Tags: Tohoku J Exp Med Source Type: research

Sight-Threatening Graves' Ophthalmopathy during the Third Trimester of Pregnancy: A Case Report.
We report a 37-year-old pregnant woman with Graves' ophthalmopathy which was deteriorated to dysthyroid optic neuropathy in the third trimester of pregnancy. Diplopia, bilateral eye lid retraction, lid edema and proptosis were observed in the 29th week of gestation. Thyroid-stimulating hormone (TSH) level was decreased with a normal level of free triiodothyronine (FT3) and an upper normal level of free thyroxine (FT4). Anti-TSH receptor antibodies (16.2 IU/L, reference range
Source: The Tohoku Journal of Experimental Medicine - December 5, 2020 Category: Research Authors: Sakurai K, Inoue T, Niitsuma S, Sato R, Takahashi K, Arihara Z Tags: Tohoku J Exp Med Source Type: research

Night-Time Urinary Frequency Is Increased after the Great East Japan Earthquake along with Seasonal Variation: A Five-Year Longitudinal Study in Kesennuma City.
In conclusion, night-time urinary frequency is increased shortly after the GEJE and remains elevated for the following three years along with seasonal variation. PMID: 33268602 [PubMed - in process] (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - December 5, 2020 Category: Research Authors: Kimura S, Sato T, Orikasa K, Nakagawa H, Ito A Tags: Tohoku J Exp Med Source Type: research

Diagnostic Value of the Hypomethylation of the WISP1 Promoter in Patients with Hepatocellular Carcinoma Associated with Hepatitis B Virus.
In conclusion, hypomethylation of the WISP1 gene promoter may serve as a noninvasive biomarker for detecting HBV-associated HCC. PMID: 33239483 [PubMed - in process] (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - November 28, 2020 Category: Research Authors: Chen LM, Xiang L, Sun WJ, Zhai YJ, Gao S, Fan YC, Wang K Tags: Tohoku J Exp Med Source Type: research

Dramatic Performance by a Professional Actor for the Treatment of Patients with Behavioral and Psychological Symptoms of Dementia.
Abstract Behavioral and psychological symptoms of dementia (BPSD) challenge caregivers, leading to caregiver burden and subsequent nursing home or inpatient placement in a psychiatric hospital for dementia. Favorable positive emotions should be an important goal for the treatment of negative emotions of BPSD. Arts are one of the most profound areas to stimulate favorable emotions. We have asked a professional actor, who was not involved in the daily care and regular rehabilitations, to give a dramatic performance by reading selected stories as if the patients with BPSD felt to be in the audiences of a theater. We ...
Source: The Tohoku Journal of Experimental Medicine - November 13, 2020 Category: Research Authors: Maeda Y, Fukushima K, Kyoutani S, Butler JP, Fujii M, Sasaki H Tags: Tohoku J Exp Med Source Type: research

Blood Pressure Phenotypes Defined by Ambulatory Blood Pressure Monitoring and Carotid Artery Changes in Community-Dwelling Older Japanese Adults: The Ohasama Study.
The objective was to investigate the associations between these blood pressure phenotypes and carotid artery changes. Conventional blood pressure, ambulatory blood pressure, and carotid ultrasonography were evaluated in 851 Ohasama residents (31.8% men; mean age 66.3 years). The blood pressure phenotypes were defined by the ordinary thresholds (140/90 mmHg for conventional blood pressure, 135/85 mmHg for daytime blood pressure) and then by the 2017 American College of Cardiology/American Heart Association (ACC/AHA) thresholds for hypertension (130/80 mmHg for both conventional and daytime blood pressure), irrespective of a...
Source: The Tohoku Journal of Experimental Medicine - November 13, 2020 Category: Research Authors: Fujita A, Hara A, Kikuya M, Asayama K, Satoh M, Asakura K, Shintani Y, Uchida S, Takatsuji Y, Murakami T, Hirose T, Tsubota-Utsugi M, Inoue R, Nomura K, Metoki H, Hozawa A, Miyazaki S, Imai Y, Ohkubo T Tags: Tohoku J Exp Med Source Type: research

Trends in Age and Histology of Testicular Cancer from 1980-2019: A Single-Center Study.
Abstract Testicular cancer occurs in the testes of the male reproductive system and is the most common cancer in adolescent and young adult (AYA) men. However, recently, there have been more cases of testicular cancer in men older than 40 years. Therefore, trends of testicular cancer during the past 40 years were retrospectively examined, focusing on age and histology. Patients who were diagnosed with testicular cancer at our institution between 1980 and 2019 were enrolled in this study. The patients were divided into groups by the year of diagnosis (1980s, 1990s, 2000s, and 2010s), age at diagnosis (14, 15 to 39,...
Source: The Tohoku Journal of Experimental Medicine - November 6, 2020 Category: Research Authors: Yamashita S, Koyama J, Goto T, Fujii S, Yamada S, Kawasaki Y, Kawamorita N, Mitsuzuka K, Arai Y, Ito A Tags: Tohoku J Exp Med Source Type: research

Double Burden of Excess Weight and Anemia in Latin American Children up to 2019.
Abstract The double burden of malnutrition is the coexistence of two different conditions, mainly reflected as excess or deficit in weight. Anemia is a specific nutritional deficit not always included in the double burden assessment. We reviewed overweight and/or obesity (OW/OB) and anemia studies from Latin-American Children over the last ten years up to 2019. Two authors evaluated the MEDLINE, SCOPUS, and LILACS databases. A scale of ten questions was used to assess the risk of bias in prevalence studies. Fourteen studies were selected. The population studies' size ranged from 147 to 20,342 children with differe...
Source: The Tohoku Journal of Experimental Medicine - October 14, 2020 Category: Research Authors: Shimabuku RL, Delgado CA, Nakachi G, Teruya AA, Velasquez PM Tags: Tohoku J Exp Med Source Type: research

Differential Diagnosis of COVID-19: Importance of Measuring Blood Lymphocytes, Serum Electrolytes, and Olfactory and Taste Functions.
In conclusion, leucocytes, leucocyte fractions, CRP, LDH, and electrolytes are useful indicators for COVID-19 diagnosis. PMID: 33028754 [PubMed - in process] (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - October 10, 2020 Category: Research Authors: Nakanishi H, Suzuki M, Maeda H, Nakamura Y, Ikegami Y, Takenaka Y, Mori Y, Hasuo T, Hasegawa C Tags: Tohoku J Exp Med Source Type: research

Visualizing the Process of Disaster Mental Health Services in the Joso Flood by Network Analyses of Emails.
Abstract Joso City, Ibaraki Prefecture, Japan was severely affected by flooding of the River Kinugawa in September 2015. Local psychiatric organizations immediately began providing disaster mental health services (DMHS). In post-disaster settings, DMHS involving organizational interventions by multiple regional institutions are required to support disaster victims. However, little is known about the process of coordinating multiple institutions or determining whether appropriate support has been provided. To elucidate the characteristics of communications that enable effective disaster medical team formation, we c...
Source: The Tohoku Journal of Experimental Medicine - October 10, 2020 Category: Research Authors: Shiratori Y, Tachikawa H, Nemoto K, Ide M, Sodeyama N, Tamura M, Takahashi S, Hori T, Arai T Tags: Tohoku J Exp Med Source Type: research

Multidisciplinary Approach to Prevent de novo Hepatitis B in Patients with Rheumatoid Arthritis.
In conclusion, our multidisciplinary approach to prevent de novo hepatitis B is considered useful. PMID: 33028756 [PubMed - in process] (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - October 10, 2020 Category: Research Authors: Watanabe R, Igarashi T, Takahashi T, Kondo H, Okazaki S, Kudo M, Ohyanagi M, Gamoh M Tags: Tohoku J Exp Med Source Type: research

Guideline-Based Medications for Older Adults Discharged after Percutaneous Coronary Intervention in a Suburban City of Japan: A Cohort Study Using Claims Data.
Abstract Secondary prevention with medications is essential for the better prognosis of patients who have experienced cardiovascular events. We aimed to evaluate the use of guideline-based medications for secondary prevention in older adults in the community settings after discharge following percutaneous coronary intervention (PCI). A retrospective cohort study was conducted using anonymized claims data of older beneficiaries in a suburban city of Japan between April 2012 and March 2015. The prescriptions of antiplatelets, statins, angiotensin-converting enzyme inhibitors (ACEi)/angiotensin II receptor blockers (...
Source: The Tohoku Journal of Experimental Medicine - October 10, 2020 Category: Research Authors: Shimada K, Hamada S, Sawano M, Yamamoto H, Yoshie S, Iijima K, Miyata H Tags: Tohoku J Exp Med Source Type: research

Concomitant Nephrotic Syndrome with Diffuse Large B-cell Lymphoma: A Case Report.
We report the rare case of a patient co-existing NS and DLBCL. DLBCL might be pathogenesis of NS; the findings are supported by the presence of MN, an underlying malignancy (DLBCL), and the lack of anti-PLA2R antibodies. Although further investigation is warranted, our case suggests that DLBCL is a possible cause of secondary MN. PMID: 33028760 [PubMed - in process] (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - October 10, 2020 Category: Research Authors: Kidoguchi K, Katsuya H, Ureshino H, Kizuka-Sano H, Yamaguchi K, Nagata A, Rikitake S, Aikawa K, Naito S, Aoki S, Kubota Y, Ando T, Kimura S Tags: Tohoku J Exp Med Source Type: research

Potential Predictors of Poor Prognosis among Critical COVID-19 Pneumonia Patients Requiring Tracheal Intubation.
Abstract Coronavirus disease 2019 (COVID-19) is a global public health concern that can be classified as mild, moderate, severe, or critical, based on disease severity. Since the identification of critical patients is crucial for developing effective management strategies, we evaluated clinical characteristics, laboratory data, treatment provided, and oxygenation to identify potential predictors of mortality among critical COVID-19 pneumonia patients. We retrospectively utilized data from seven critical patients who were admitted to our hospital during April 2020 and required mechanical ventilation. The primary en...
Source: The Tohoku Journal of Experimental Medicine - September 18, 2020 Category: Research Authors: Kishaba T, Maeda A, Nabeya D, Nagano H Tags: Tohoku J Exp Med Source Type: research

Selection of and Retention in Surgical Specialty during Early Career in Japan.
Abstract The number of surgeons is decreasing in Japan. We investigated the trend and factors influencing surgeons' selection of and retention in surgical specialty. In 2016, we obtained data of biennial surveys conducted by the government, and analyzed the annual data of doctors up to the latest available survey at that time (survey, 1994-2014; medical license acquisition, 1993-2014). The rate of selecting surgery by male and female doctors during early career (first three surveys after acquiring medical license) decreased from 28.1% in 1994 to 21.3% in 2010 (first to nineth survey). Female surgeons increased fro...
Source: The Tohoku Journal of Experimental Medicine - September 18, 2020 Category: Research Authors: Tomizawa Y, Miyazaki S, Matsumoto T, Uetsuka Y Tags: Tohoku J Exp Med Source Type: research

Mortality Risk Factors among Hospitalized COVID-19 Patients in a Major Referral Center in Iran.
Abstract The Coronavirus Disease 2019 (COVID-19) pandemic has killed many people worldwide since December 2019, and Iran has been among the most affected countries. In this retrospective study, we aimed to determine the prognostic factors associated with mortality in COVID-19 patients by analyzing 396 survived and 63 non-survived patients in Shahid Modarres Hospital, Tehran, Iran, from January 30th until April 5th, 2020. As the results, the BMI> 35 (p = 0.0003), lung cancer (p = 0.007), chronic kidney disease (p = 0.002), Immunocompromised condition (p = 0.003), and diabetes (p = 0.018) were more frequently obs...
Source: The Tohoku Journal of Experimental Medicine - September 13, 2020 Category: Research Authors: Alamdari NM, Afaghi S, Rahimi FS, Tarki FE, Tavana S, Zali A, Fathi M, Besharat S, Bagheri L, Pourmotahari F, Irvani SSN, Dabbagh A, Mousavi SA Tags: Tohoku J Exp Med Source Type: research

Recombinant Human Soluble Thrombomodulin Contributes to a Reduction In-Hospital Mortality of Acute Cholangitis with Disseminated Intravascular Coagulation: A Propensity Score Analyses of a Japanese Nationwide Database.
This study aimed to validate the hypothesis that rhTM use improves in-hospital mortality in patients with acute cholangitis with DIC. A propensity score-matching analysis using a nationwide administrative database, the Japanese Diagnosis Procedure Combination Inpatient Database from April 2012 to March 2018, was performed. This database includes administrative claims data for all inpatients discharged from more than 1,000 participating hospitals, covering 92% of all tertiary-care emergency hospitals in Japan. Eligible patients (n = 2,865) were categorized into the rhTM (n = 1,636) or control groups (n = 1,229). Propensity ...
Source: The Tohoku Journal of Experimental Medicine - September 4, 2020 Category: Research Authors: Tarasawa K, Fujimori K, Fushimi K Tags: Tohoku J Exp Med Source Type: research

Focal Parenchymal Atrophy and Fat Replacement Are Clues for Early Diagnosis of Pancreatic Cancer with Abnormalities of the Main Pancreatic Duct.
In conclusion, focal parenchymal atrophy and fat replacement may provide clues for the early diagnosis of pancreatic cancer. PMID: 32879148 [PubMed - in process] (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - September 4, 2020 Category: Research Authors: Miura S, Kume K, Kikuta K, Hamada S, Takikawa T, Yoshida N, Hongo S, Tanaka Y, Matsumoto R, Sano T, Ikeda M, Furukawa T, Iseki M, Unno M, Masamune A Tags: Tohoku J Exp Med Source Type: research

Hybrid Training System Improves Insulin Resistance in Patients with Nonalcoholic Fatty Liver Disease: A Randomized Controlled Pilot Study.
We examined subjects before the first session and at the end of the final session. Serum SeP levels were measured by ELISA which measures the fragment of SeP. In the HTS group, HOMA-IR values were significantly reduced compared to the control group (Δ-0.71 vs. Δ0.05; P
Source: The Tohoku Journal of Experimental Medicine - September 1, 2020 Category: Research Authors: Iwanaga S, Hashida R, Takano Y, Bekki M, Nakano D, Omoto M, Nago T, Kawaguchi T, Matsuse H, Torimura T, Shiba N Tags: Tohoku J Exp Med Source Type: research

Coparenting Intervention for Expectant Parents Affects Relationship Quality: A Pilot Study.
Abstract Research has shown that the transition to parenthood is a particularly challenging period of life which is often associated with a decline in relationship quality and an increase in mental health problems. Emerging parents often experience difficulties in coping with new tasks and challenges in the relationship, resulting in inadequate mutual support, stress, conflicts and even depressive symptoms. To support expectant parents in establishing an effective and strong coparenting alliance, we have employed an educational coparenting intervention to teach important coparenting skills. The intervention was a ...
Source: The Tohoku Journal of Experimental Medicine - September 1, 2020 Category: Research Authors: Philipp AC, Lee JK, Stamm TA, Wininger M, Datler W, Kapusta ND Tags: Tohoku J Exp Med Source Type: research

Refractory Hypertension in Infantile-Onset Denys-Drash Syndrome.
Abstract Denys-Drash syndrome is characterized by progressive nephropathy, gonadal dysgenesis, and Wilms tumor caused by a WT1 gene mutation. Infants with Denys-Drash syndrome frequently experience severe hypertension, but detailed clinical manifestations have yet to be clarified. Cases of infantile-onset Denys-Drash syndrome with severe hypertension at our hospital were retrospectively analyzed and the pathogenesis of hypertension was investigated. Six infants who received the diagnosis of Denys-Drash syndrome at the median age of 10 days (range: 2-182 days) were enrolled. Five infants had the complication of sev...
Source: The Tohoku Journal of Experimental Medicine - September 1, 2020 Category: Research Authors: Nishi K, Kamei K, Ogura M, Sato M, Murakoshi M, Kamae C, Suzuki R, Kanamori T, Nagano C, Nozu K, Ishikura K, Ito S Tags: Tohoku J Exp Med Source Type: research

Shorter Interval between Onset and Admission to Convalescent Rehabilitation Wards Is Associated with Improved Outcomes in Ischemic Stroke Patients.
In conclusion, a shorter interval between stroke onset and admission to convalescent rehabilitation wards contributes to improved outcomes, including ADLs, dysphagia, and a discharge rate to home, in ischemic stroke patients, regardless of stroke severity. PMID: 32848123 [PubMed - in process] (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - August 29, 2020 Category: Research Authors: Yoshimura Y, Wakabayashi H, Momosaki R, Nagano F, Shimazu S, Shiraishi A Tags: Tohoku J Exp Med Source Type: research

Coronavirus Disease 2019: Hematological Anomalies and Antithrombotic Therapy.
Abstract After the first cases of COVID-19 appeared in Wuhan, China at the end of 2019, the disease quickly become a pandemic that has seriously affected the economic and health systems in more than 200 countries and territories around the world. Although most patients have mild symptoms or are even asymptomatic, there are patients who can develop serious complications such as acute respiratory distress syndrome or venous thromboembolism requiring mechanical ventilation and intensive care. Hence, it is important to identify patients with a higher risk of complications in a timely manner. Thus, the objective of thi...
Source: The Tohoku Journal of Experimental Medicine - August 15, 2020 Category: Research Authors: Ornelas-Ricardo D, Jaloma-Cruz AR Tags: Tohoku J Exp Med Source Type: research

Preoperative In-Hospital Rehabilitation Improves Physical Function in Patients with Pancreatic Cancer Scheduled for Surgery.
Abstract Low preoperative physical function in cancer patients is associated with postoperative complications; however, there have been no reports on the benefits of in-hospital preoperative rehabilitation on preoperative physical function in patients with pancreatic cancer. Therefore, the aim of this study was to quantitatively determine the effects of preoperative in-hospital rehabilitation provided under the supervision of a physiotherapist, on preoperative physical function in patients with pancreatic cancer. The study subjects were 26 patients (15 males, 11 females; age 71.2 ± 8.5 years, range: 51-87 y...
Source: The Tohoku Journal of Experimental Medicine - August 14, 2020 Category: Research Authors: Mikami Y, Kouda K, Kawasaki S, Okada KI, Kawai M, Kitahata Y, Miyazawa M, Hirono S, Unno M, Tajima F, Yamaue H Tags: Tohoku J Exp Med Source Type: research

Human Papillomavirus (HPV) Genotyping Assay Suitable for Monitoring the Impact of the 9-Valent HPV Vaccine.
In conclusion, while the two assays present equivalent data for assessing the effectiveness of the bivalent and quadrivalent vaccines, PGMY-CHUV is more suitable for evaluating the impact of the current 9-valent vaccine because of its superior detection of HPV52 in co-infection cases. PMID: 32759554 [PubMed - in process] (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - August 14, 2020 Category: Research Authors: Kukimoto I, Matsumoto K, Takahashi F, Iwata T, Tanaka K, Yamaguchi-Naka M, Yamamoto K, Yahata H, Nakabayashi M, Kato H, Tsuda N, Onuki M, Yaegashi N, MINT Study II Group Tags: Tohoku J Exp Med Source Type: research

Low Back Pain in School-Aged Martial Arts Athletes in Japan: A Comparison among Judo, Kendo, and Karate.
Abstract Martial arts, such as judo, kendo, and karate, are popular worldwide, not only among adults but also among children and adolescents. Although low back pain (LBP) is considered to be a common problem in these sports, it has been scarcely studied, especially in young athletes. The purpose of this study was to elucidate the point prevalence of and factors related to LBP among school-aged athletes in judo, kendo, and karate. A cross-sectional study was conducted in school-aged athletes (age, 6-15 years; n = 896) using a self-reported questionnaire. Multiple logistic regression models were used to assess the f...
Source: The Tohoku Journal of Experimental Medicine - August 14, 2020 Category: Research Authors: Yabe Y, Hagiwara Y, Sekiguchi T, Momma H, Tsuchiya M, Kanazawa K, Yoshida S, Sogi Y, Yano T, Onoki T, Itoi E, Nagatomi R Tags: Tohoku J Exp Med Source Type: research

Neutrophil-to-Lymphocyte Ratio and Intratumoral CD45RO-Positive T Cells as Predictive Factors for Longer Survival of Patients with Colorectal Liver Metastasis after Hepatectomy.
Abstract Colorectal cancer is the fourth most common malignancy across the world, and over 50% of patients had colorectal liver metastases (CLM). Activated neutrophils and tumor-infiltrating lymphocytes (TILs) are considered to interrupt progression of primary colorectal cancer; however, immunological host reactions to CLM have not been fully elucidated. We thus aimed to explore the prognostic implication of neutrophil-to-lymphocyte ratio (NLR) in peripheral blood and TILs in resected metastatic cancer tissues of 29 patients with CLM who underwent hepatectomy. To evaluate local immunological responses in CLM, we e...
Source: The Tohoku Journal of Experimental Medicine - August 14, 2020 Category: Research Authors: Hamada T, Ishizaki H, Haruyama Y, Hamada R, Yano K, Kondo K, Kataoka H, Nanashima A Tags: Tohoku J Exp Med Source Type: research

The Roles of MicroRNAs and Extracellular Vesicles in the Pathogeneses of Idiopathic Pulmonary Fibrosis and Acute Respiratory Distress Syndrome.
Abstract The lungs are the organs that work for gas exchange. The basic structure of the lungs is an alveolus, which consists of various types of parenchymal cells and bone marrow-derived cells. Therefore, because the lungs consist of various types of cells with various functions, communication among the different types of the cells should play important roles for the homeostasis and response to disease pathogens. In the past decades, researchers have focused on cytokines or adhesion molecules to reveal the intercellular communication for understanding the homeostasis and pathogenesis in the lungs. Recent investig...
Source: The Tohoku Journal of Experimental Medicine - August 14, 2020 Category: Research Authors: Yamada M Tags: Tohoku J Exp Med Source Type: research

MicroRNA Let-7c Contributes to Paclitaxel Resistance via Aurora-B in Endometrial Serous Carcinoma.
Abstract The incidence of endometrial cancer has rapidly risen over recent years. Paclitaxel, a key drug for endometrial cancer treatment, inhibits microtubule depolymerization and induces apoptosis in cancer cells. Endometrial serous carcinoma (ESC) accounts for
Source: The Tohoku Journal of Experimental Medicine - August 1, 2020 Category: Research Authors: Sato I, Ishibashi M, Tokunaga H, Shigeta S, Sakurada S, Shimada M, Nagase S, Watanabe Y, Yaegashi N Tags: Tohoku J Exp Med Source Type: research

Salmonella Osteomyelitis of the Rib Mimicking a Mammary Tumor: A Case Report.
Abstract Salmonella infection predominantly causes four clinical syndromes: enteric fever, gastroenteritis, bacteremia, and asymptomatic carrier state. Salmonella osteomyelitis is an extremely rare manifestation of salmonella infection except in children with hemoglobinopathies. Salmonella osteomyelitis has been reported to mostly affect the diaphysis of long bones and lumbar spine. Here, we describe a case of salmonella osteomyelitis of the right 6th rib in a 74-year-old woman who presented with breast pain, swelling, high fever and local heat. Her medical history showed myocardial infarction; namely, at the age ...
Source: The Tohoku Journal of Experimental Medicine - August 1, 2020 Category: Research Authors: Hashimoto K, Nishimura S, Matsumura D, Ohtani K, Akagi M Tags: Tohoku J Exp Med Source Type: research

The Natural History of Spontaneously Occurred Endometriosis in Cynomolgus Monkeys by Monthly Follow-Up Laparoscopy for Two Years.
Abstract Endometriosis, a disease in which endometrial tissue proliferates outside the uterus, is a progressive disease that affects women in reproductive age. It causes abdominal pain and infertility that severely affects the quality of life in young women. The mechanism of the onset and development of endometriosis has not been fully elucidated because of the complex mechanism involved in the disease. Nonhuman primates have been used to study the pathogenesis of spontaneous endometriosis because of their gynecological and anatomical similarities to humans. To reveal the natural history of endometriosis in cynomo...
Source: The Tohoku Journal of Experimental Medicine - July 29, 2020 Category: Research Authors: Hayashi K, Nakayama M, Iwatani C, Tsuchiya H, Nakamura S, Nonoguchi K, Itoh Y, Tsuji S, Ishigaki H, Mori T, Murakami T, Ogasawara K Tags: Tohoku J Exp Med Source Type: research

Serum Elabela Levels Are Elevated in Patients with Hyperthyroidism.
Abstract The apelinergic system plays an important role in the modulation of the cardiovascular system via the apelin peptide and the apelin receptor (APJ receptor). Apelin and elabela, also known toddler, are peptide ligands for the apelin receptor. These two peptides show similar biological actions, such as vasodilatation, increased myocardial contractility, angiogenesis, and energy metabolism. However, the serum levels of elabela in patients with hyperthyroidism are not well known. The aim of this study was to investigate the changes in serum elabela levels in patients with hyperthyroidism and its association w...
Source: The Tohoku Journal of Experimental Medicine - July 29, 2020 Category: Research Authors: Buyuksimsek M, Gulumsek E, Aslan MZ, Ozturk HA, Bashir AM, Icen YK, Ay N, Acibucu F, Koc M, Sumbul HE, Saler T Tags: Tohoku J Exp Med Source Type: research

Serum Alanine Transaminase as a Predictor of Type 2 Diabetes Incidence: The Yuport Prospective Cohort Study.
Abstract Prior studies have shown an association between the incidence of diabetes with liver enzymes, such as alanine transaminase (ALT). Liver fibrosis scores, such as the Fibrosis-4 index which indicates chronic liver damage, were also associated with diabetes development. However, no literature compared predictive accuracy between ALT and Fibrosis-4 index. Thus, we aimed to determine it, and to assess its association using inverse probability of treatment weighting. This was a non-concurrent prospective cohort study of 9,748 subjects without diabetes receiving Yuport Health Checkup in Japan between 1998 and 20...
Source: The Tohoku Journal of Experimental Medicine - July 18, 2020 Category: Research Authors: Hatano Y, Inoue K, Kashima S, Matsumoto M, Akimoto K Tags: Tohoku J Exp Med Source Type: research