Trends in Age and Histology of Testicular Cancer from 1980-2019: A Single-Center Study.
Abstract Testicular cancer occurs in the testes of the male reproductive system and is the most common cancer in adolescent and young adult (AYA) men. However, recently, there have been more cases of testicular cancer in men older than 40 years. Therefore, trends of testicular cancer during the past 40 years were retrospectively examined, focusing on age and histology. Patients who were diagnosed with testicular cancer at our institution between 1980 and 2019 were enrolled in this study. The patients were divided into groups by the year of diagnosis (1980s, 1990s, 2000s, and 2010s), age at diagnosis (14, 15 to 39,...
Source: The Tohoku Journal of Experimental Medicine - November 6, 2020 Category: Research Authors: Yamashita S, Koyama J, Goto T, Fujii S, Yamada S, Kawasaki Y, Kawamorita N, Mitsuzuka K, Arai Y, Ito A Tags: Tohoku J Exp Med Source Type: research

Double Burden of Excess Weight and Anemia in Latin American Children up to 2019.
Abstract The double burden of malnutrition is the coexistence of two different conditions, mainly reflected as excess or deficit in weight. Anemia is a specific nutritional deficit not always included in the double burden assessment. We reviewed overweight and/or obesity (OW/OB) and anemia studies from Latin-American Children over the last ten years up to 2019. Two authors evaluated the MEDLINE, SCOPUS, and LILACS databases. A scale of ten questions was used to assess the risk of bias in prevalence studies. Fourteen studies were selected. The population studies' size ranged from 147 to 20,342 children with differe...
Source: The Tohoku Journal of Experimental Medicine - October 14, 2020 Category: Research Authors: Shimabuku RL, Delgado CA, Nakachi G, Teruya AA, Velasquez PM Tags: Tohoku J Exp Med Source Type: research

Differential Diagnosis of COVID-19: Importance of Measuring Blood Lymphocytes, Serum Electrolytes, and Olfactory and Taste Functions.
In conclusion, leucocytes, leucocyte fractions, CRP, LDH, and electrolytes are useful indicators for COVID-19 diagnosis. PMID: 33028754 [PubMed - in process] (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - October 10, 2020 Category: Research Authors: Nakanishi H, Suzuki M, Maeda H, Nakamura Y, Ikegami Y, Takenaka Y, Mori Y, Hasuo T, Hasegawa C Tags: Tohoku J Exp Med Source Type: research

Visualizing the Process of Disaster Mental Health Services in the Joso Flood by Network Analyses of Emails.
Abstract Joso City, Ibaraki Prefecture, Japan was severely affected by flooding of the River Kinugawa in September 2015. Local psychiatric organizations immediately began providing disaster mental health services (DMHS). In post-disaster settings, DMHS involving organizational interventions by multiple regional institutions are required to support disaster victims. However, little is known about the process of coordinating multiple institutions or determining whether appropriate support has been provided. To elucidate the characteristics of communications that enable effective disaster medical team formation, we c...
Source: The Tohoku Journal of Experimental Medicine - October 10, 2020 Category: Research Authors: Shiratori Y, Tachikawa H, Nemoto K, Ide M, Sodeyama N, Tamura M, Takahashi S, Hori T, Arai T Tags: Tohoku J Exp Med Source Type: research

Multidisciplinary Approach to Prevent de novo Hepatitis B in Patients with Rheumatoid Arthritis.
In conclusion, our multidisciplinary approach to prevent de novo hepatitis B is considered useful. PMID: 33028756 [PubMed - in process] (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - October 10, 2020 Category: Research Authors: Watanabe R, Igarashi T, Takahashi T, Kondo H, Okazaki S, Kudo M, Ohyanagi M, Gamoh M Tags: Tohoku J Exp Med Source Type: research

Guideline-Based Medications for Older Adults Discharged after Percutaneous Coronary Intervention in a Suburban City of Japan: A Cohort Study Using Claims Data.
Abstract Secondary prevention with medications is essential for the better prognosis of patients who have experienced cardiovascular events. We aimed to evaluate the use of guideline-based medications for secondary prevention in older adults in the community settings after discharge following percutaneous coronary intervention (PCI). A retrospective cohort study was conducted using anonymized claims data of older beneficiaries in a suburban city of Japan between April 2012 and March 2015. The prescriptions of antiplatelets, statins, angiotensin-converting enzyme inhibitors (ACEi)/angiotensin II receptor blockers (...
Source: The Tohoku Journal of Experimental Medicine - October 10, 2020 Category: Research Authors: Shimada K, Hamada S, Sawano M, Yamamoto H, Yoshie S, Iijima K, Miyata H Tags: Tohoku J Exp Med Source Type: research

Concomitant Nephrotic Syndrome with Diffuse Large B-cell Lymphoma: A Case Report.
We report the rare case of a patient co-existing NS and DLBCL. DLBCL might be pathogenesis of NS; the findings are supported by the presence of MN, an underlying malignancy (DLBCL), and the lack of anti-PLA2R antibodies. Although further investigation is warranted, our case suggests that DLBCL is a possible cause of secondary MN. PMID: 33028760 [PubMed - in process] (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - October 10, 2020 Category: Research Authors: Kidoguchi K, Katsuya H, Ureshino H, Kizuka-Sano H, Yamaguchi K, Nagata A, Rikitake S, Aikawa K, Naito S, Aoki S, Kubota Y, Ando T, Kimura S Tags: Tohoku J Exp Med Source Type: research

Potential Predictors of Poor Prognosis among Critical COVID-19 Pneumonia Patients Requiring Tracheal Intubation.
Abstract Coronavirus disease 2019 (COVID-19) is a global public health concern that can be classified as mild, moderate, severe, or critical, based on disease severity. Since the identification of critical patients is crucial for developing effective management strategies, we evaluated clinical characteristics, laboratory data, treatment provided, and oxygenation to identify potential predictors of mortality among critical COVID-19 pneumonia patients. We retrospectively utilized data from seven critical patients who were admitted to our hospital during April 2020 and required mechanical ventilation. The primary en...
Source: The Tohoku Journal of Experimental Medicine - September 18, 2020 Category: Research Authors: Kishaba T, Maeda A, Nabeya D, Nagano H Tags: Tohoku J Exp Med Source Type: research

Selection of and Retention in Surgical Specialty during Early Career in Japan.
Abstract The number of surgeons is decreasing in Japan. We investigated the trend and factors influencing surgeons' selection of and retention in surgical specialty. In 2016, we obtained data of biennial surveys conducted by the government, and analyzed the annual data of doctors up to the latest available survey at that time (survey, 1994-2014; medical license acquisition, 1993-2014). The rate of selecting surgery by male and female doctors during early career (first three surveys after acquiring medical license) decreased from 28.1% in 1994 to 21.3% in 2010 (first to nineth survey). Female surgeons increased fro...
Source: The Tohoku Journal of Experimental Medicine - September 18, 2020 Category: Research Authors: Tomizawa Y, Miyazaki S, Matsumoto T, Uetsuka Y Tags: Tohoku J Exp Med Source Type: research

Mortality Risk Factors among Hospitalized COVID-19 Patients in a Major Referral Center in Iran.
Abstract The Coronavirus Disease 2019 (COVID-19) pandemic has killed many people worldwide since December 2019, and Iran has been among the most affected countries. In this retrospective study, we aimed to determine the prognostic factors associated with mortality in COVID-19 patients by analyzing 396 survived and 63 non-survived patients in Shahid Modarres Hospital, Tehran, Iran, from January 30th until April 5th, 2020. As the results, the BMI> 35 (p = 0.0003), lung cancer (p = 0.007), chronic kidney disease (p = 0.002), Immunocompromised condition (p = 0.003), and diabetes (p = 0.018) were more frequently obs...
Source: The Tohoku Journal of Experimental Medicine - September 13, 2020 Category: Research Authors: Alamdari NM, Afaghi S, Rahimi FS, Tarki FE, Tavana S, Zali A, Fathi M, Besharat S, Bagheri L, Pourmotahari F, Irvani SSN, Dabbagh A, Mousavi SA Tags: Tohoku J Exp Med Source Type: research

Recombinant Human Soluble Thrombomodulin Contributes to a Reduction In-Hospital Mortality of Acute Cholangitis with Disseminated Intravascular Coagulation: A Propensity Score Analyses of a Japanese Nationwide Database.
This study aimed to validate the hypothesis that rhTM use improves in-hospital mortality in patients with acute cholangitis with DIC. A propensity score-matching analysis using a nationwide administrative database, the Japanese Diagnosis Procedure Combination Inpatient Database from April 2012 to March 2018, was performed. This database includes administrative claims data for all inpatients discharged from more than 1,000 participating hospitals, covering 92% of all tertiary-care emergency hospitals in Japan. Eligible patients (n = 2,865) were categorized into the rhTM (n = 1,636) or control groups (n = 1,229). Propensity ...
Source: The Tohoku Journal of Experimental Medicine - September 4, 2020 Category: Research Authors: Tarasawa K, Fujimori K, Fushimi K Tags: Tohoku J Exp Med Source Type: research

Focal Parenchymal Atrophy and Fat Replacement Are Clues for Early Diagnosis of Pancreatic Cancer with Abnormalities of the Main Pancreatic Duct.
In conclusion, focal parenchymal atrophy and fat replacement may provide clues for the early diagnosis of pancreatic cancer. PMID: 32879148 [PubMed - in process] (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - September 4, 2020 Category: Research Authors: Miura S, Kume K, Kikuta K, Hamada S, Takikawa T, Yoshida N, Hongo S, Tanaka Y, Matsumoto R, Sano T, Ikeda M, Furukawa T, Iseki M, Unno M, Masamune A Tags: Tohoku J Exp Med Source Type: research

Hybrid Training System Improves Insulin Resistance in Patients with Nonalcoholic Fatty Liver Disease: A Randomized Controlled Pilot Study.
We examined subjects before the first session and at the end of the final session. Serum SeP levels were measured by ELISA which measures the fragment of SeP. In the HTS group, HOMA-IR values were significantly reduced compared to the control group (Δ-0.71 vs. Δ0.05; P
Source: The Tohoku Journal of Experimental Medicine - September 1, 2020 Category: Research Authors: Iwanaga S, Hashida R, Takano Y, Bekki M, Nakano D, Omoto M, Nago T, Kawaguchi T, Matsuse H, Torimura T, Shiba N Tags: Tohoku J Exp Med Source Type: research

Coparenting Intervention for Expectant Parents Affects Relationship Quality: A Pilot Study.
Abstract Research has shown that the transition to parenthood is a particularly challenging period of life which is often associated with a decline in relationship quality and an increase in mental health problems. Emerging parents often experience difficulties in coping with new tasks and challenges in the relationship, resulting in inadequate mutual support, stress, conflicts and even depressive symptoms. To support expectant parents in establishing an effective and strong coparenting alliance, we have employed an educational coparenting intervention to teach important coparenting skills. The intervention was a ...
Source: The Tohoku Journal of Experimental Medicine - September 1, 2020 Category: Research Authors: Philipp AC, Lee JK, Stamm TA, Wininger M, Datler W, Kapusta ND Tags: Tohoku J Exp Med Source Type: research

Refractory Hypertension in Infantile-Onset Denys-Drash Syndrome.
Abstract Denys-Drash syndrome is characterized by progressive nephropathy, gonadal dysgenesis, and Wilms tumor caused by a WT1 gene mutation. Infants with Denys-Drash syndrome frequently experience severe hypertension, but detailed clinical manifestations have yet to be clarified. Cases of infantile-onset Denys-Drash syndrome with severe hypertension at our hospital were retrospectively analyzed and the pathogenesis of hypertension was investigated. Six infants who received the diagnosis of Denys-Drash syndrome at the median age of 10 days (range: 2-182 days) were enrolled. Five infants had the complication of sev...
Source: The Tohoku Journal of Experimental Medicine - September 1, 2020 Category: Research Authors: Nishi K, Kamei K, Ogura M, Sato M, Murakoshi M, Kamae C, Suzuki R, Kanamori T, Nagano C, Nozu K, Ishikura K, Ito S Tags: Tohoku J Exp Med Source Type: research

Shorter Interval between Onset and Admission to Convalescent Rehabilitation Wards Is Associated with Improved Outcomes in Ischemic Stroke Patients.
In conclusion, a shorter interval between stroke onset and admission to convalescent rehabilitation wards contributes to improved outcomes, including ADLs, dysphagia, and a discharge rate to home, in ischemic stroke patients, regardless of stroke severity. PMID: 32848123 [PubMed - in process] (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - August 29, 2020 Category: Research Authors: Yoshimura Y, Wakabayashi H, Momosaki R, Nagano F, Shimazu S, Shiraishi A Tags: Tohoku J Exp Med Source Type: research

Coronavirus Disease 2019: Hematological Anomalies and Antithrombotic Therapy.
Abstract After the first cases of COVID-19 appeared in Wuhan, China at the end of 2019, the disease quickly become a pandemic that has seriously affected the economic and health systems in more than 200 countries and territories around the world. Although most patients have mild symptoms or are even asymptomatic, there are patients who can develop serious complications such as acute respiratory distress syndrome or venous thromboembolism requiring mechanical ventilation and intensive care. Hence, it is important to identify patients with a higher risk of complications in a timely manner. Thus, the objective of thi...
Source: The Tohoku Journal of Experimental Medicine - August 15, 2020 Category: Research Authors: Ornelas-Ricardo D, Jaloma-Cruz AR Tags: Tohoku J Exp Med Source Type: research

Preoperative In-Hospital Rehabilitation Improves Physical Function in Patients with Pancreatic Cancer Scheduled for Surgery.
Abstract Low preoperative physical function in cancer patients is associated with postoperative complications; however, there have been no reports on the benefits of in-hospital preoperative rehabilitation on preoperative physical function in patients with pancreatic cancer. Therefore, the aim of this study was to quantitatively determine the effects of preoperative in-hospital rehabilitation provided under the supervision of a physiotherapist, on preoperative physical function in patients with pancreatic cancer. The study subjects were 26 patients (15 males, 11 females; age 71.2 ± 8.5 years, range: 51-87 y...
Source: The Tohoku Journal of Experimental Medicine - August 14, 2020 Category: Research Authors: Mikami Y, Kouda K, Kawasaki S, Okada KI, Kawai M, Kitahata Y, Miyazawa M, Hirono S, Unno M, Tajima F, Yamaue H Tags: Tohoku J Exp Med Source Type: research

Human Papillomavirus (HPV) Genotyping Assay Suitable for Monitoring the Impact of the 9-Valent HPV Vaccine.
In conclusion, while the two assays present equivalent data for assessing the effectiveness of the bivalent and quadrivalent vaccines, PGMY-CHUV is more suitable for evaluating the impact of the current 9-valent vaccine because of its superior detection of HPV52 in co-infection cases. PMID: 32759554 [PubMed - in process] (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - August 14, 2020 Category: Research Authors: Kukimoto I, Matsumoto K, Takahashi F, Iwata T, Tanaka K, Yamaguchi-Naka M, Yamamoto K, Yahata H, Nakabayashi M, Kato H, Tsuda N, Onuki M, Yaegashi N, MINT Study II Group Tags: Tohoku J Exp Med Source Type: research

Low Back Pain in School-Aged Martial Arts Athletes in Japan: A Comparison among Judo, Kendo, and Karate.
Abstract Martial arts, such as judo, kendo, and karate, are popular worldwide, not only among adults but also among children and adolescents. Although low back pain (LBP) is considered to be a common problem in these sports, it has been scarcely studied, especially in young athletes. The purpose of this study was to elucidate the point prevalence of and factors related to LBP among school-aged athletes in judo, kendo, and karate. A cross-sectional study was conducted in school-aged athletes (age, 6-15 years; n = 896) using a self-reported questionnaire. Multiple logistic regression models were used to assess the f...
Source: The Tohoku Journal of Experimental Medicine - August 14, 2020 Category: Research Authors: Yabe Y, Hagiwara Y, Sekiguchi T, Momma H, Tsuchiya M, Kanazawa K, Yoshida S, Sogi Y, Yano T, Onoki T, Itoi E, Nagatomi R Tags: Tohoku J Exp Med Source Type: research

Neutrophil-to-Lymphocyte Ratio and Intratumoral CD45RO-Positive T Cells as Predictive Factors for Longer Survival of Patients with Colorectal Liver Metastasis after Hepatectomy.
Abstract Colorectal cancer is the fourth most common malignancy across the world, and over 50% of patients had colorectal liver metastases (CLM). Activated neutrophils and tumor-infiltrating lymphocytes (TILs) are considered to interrupt progression of primary colorectal cancer; however, immunological host reactions to CLM have not been fully elucidated. We thus aimed to explore the prognostic implication of neutrophil-to-lymphocyte ratio (NLR) in peripheral blood and TILs in resected metastatic cancer tissues of 29 patients with CLM who underwent hepatectomy. To evaluate local immunological responses in CLM, we e...
Source: The Tohoku Journal of Experimental Medicine - August 14, 2020 Category: Research Authors: Hamada T, Ishizaki H, Haruyama Y, Hamada R, Yano K, Kondo K, Kataoka H, Nanashima A Tags: Tohoku J Exp Med Source Type: research

The Roles of MicroRNAs and Extracellular Vesicles in the Pathogeneses of Idiopathic Pulmonary Fibrosis and Acute Respiratory Distress Syndrome.
Abstract The lungs are the organs that work for gas exchange. The basic structure of the lungs is an alveolus, which consists of various types of parenchymal cells and bone marrow-derived cells. Therefore, because the lungs consist of various types of cells with various functions, communication among the different types of the cells should play important roles for the homeostasis and response to disease pathogens. In the past decades, researchers have focused on cytokines or adhesion molecules to reveal the intercellular communication for understanding the homeostasis and pathogenesis in the lungs. Recent investig...
Source: The Tohoku Journal of Experimental Medicine - August 14, 2020 Category: Research Authors: Yamada M Tags: Tohoku J Exp Med Source Type: research

MicroRNA Let-7c Contributes to Paclitaxel Resistance via Aurora-B in Endometrial Serous Carcinoma.
Abstract The incidence of endometrial cancer has rapidly risen over recent years. Paclitaxel, a key drug for endometrial cancer treatment, inhibits microtubule depolymerization and induces apoptosis in cancer cells. Endometrial serous carcinoma (ESC) accounts for
Source: The Tohoku Journal of Experimental Medicine - August 1, 2020 Category: Research Authors: Sato I, Ishibashi M, Tokunaga H, Shigeta S, Sakurada S, Shimada M, Nagase S, Watanabe Y, Yaegashi N Tags: Tohoku J Exp Med Source Type: research

Salmonella Osteomyelitis of the Rib Mimicking a Mammary Tumor: A Case Report.
Abstract Salmonella infection predominantly causes four clinical syndromes: enteric fever, gastroenteritis, bacteremia, and asymptomatic carrier state. Salmonella osteomyelitis is an extremely rare manifestation of salmonella infection except in children with hemoglobinopathies. Salmonella osteomyelitis has been reported to mostly affect the diaphysis of long bones and lumbar spine. Here, we describe a case of salmonella osteomyelitis of the right 6th rib in a 74-year-old woman who presented with breast pain, swelling, high fever and local heat. Her medical history showed myocardial infarction; namely, at the age ...
Source: The Tohoku Journal of Experimental Medicine - August 1, 2020 Category: Research Authors: Hashimoto K, Nishimura S, Matsumura D, Ohtani K, Akagi M Tags: Tohoku J Exp Med Source Type: research

The Natural History of Spontaneously Occurred Endometriosis in Cynomolgus Monkeys by Monthly Follow-Up Laparoscopy for Two Years.
Abstract Endometriosis, a disease in which endometrial tissue proliferates outside the uterus, is a progressive disease that affects women in reproductive age. It causes abdominal pain and infertility that severely affects the quality of life in young women. The mechanism of the onset and development of endometriosis has not been fully elucidated because of the complex mechanism involved in the disease. Nonhuman primates have been used to study the pathogenesis of spontaneous endometriosis because of their gynecological and anatomical similarities to humans. To reveal the natural history of endometriosis in cynomo...
Source: The Tohoku Journal of Experimental Medicine - July 29, 2020 Category: Research Authors: Hayashi K, Nakayama M, Iwatani C, Tsuchiya H, Nakamura S, Nonoguchi K, Itoh Y, Tsuji S, Ishigaki H, Mori T, Murakami T, Ogasawara K Tags: Tohoku J Exp Med Source Type: research

Serum Elabela Levels Are Elevated in Patients with Hyperthyroidism.
Abstract The apelinergic system plays an important role in the modulation of the cardiovascular system via the apelin peptide and the apelin receptor (APJ receptor). Apelin and elabela, also known toddler, are peptide ligands for the apelin receptor. These two peptides show similar biological actions, such as vasodilatation, increased myocardial contractility, angiogenesis, and energy metabolism. However, the serum levels of elabela in patients with hyperthyroidism are not well known. The aim of this study was to investigate the changes in serum elabela levels in patients with hyperthyroidism and its association w...
Source: The Tohoku Journal of Experimental Medicine - July 29, 2020 Category: Research Authors: Buyuksimsek M, Gulumsek E, Aslan MZ, Ozturk HA, Bashir AM, Icen YK, Ay N, Acibucu F, Koc M, Sumbul HE, Saler T Tags: Tohoku J Exp Med Source Type: research

Serum Alanine Transaminase as a Predictor of Type 2 Diabetes Incidence: The Yuport Prospective Cohort Study.
Abstract Prior studies have shown an association between the incidence of diabetes with liver enzymes, such as alanine transaminase (ALT). Liver fibrosis scores, such as the Fibrosis-4 index which indicates chronic liver damage, were also associated with diabetes development. However, no literature compared predictive accuracy between ALT and Fibrosis-4 index. Thus, we aimed to determine it, and to assess its association using inverse probability of treatment weighting. This was a non-concurrent prospective cohort study of 9,748 subjects without diabetes receiving Yuport Health Checkup in Japan between 1998 and 20...
Source: The Tohoku Journal of Experimental Medicine - July 18, 2020 Category: Research Authors: Hatano Y, Inoue K, Kashima S, Matsumoto M, Akimoto K Tags: Tohoku J Exp Med Source Type: research

Core Stability and Hip Exercises Improve Physical Function and Activity in Patients with Non-Specific Low Back Pain: A Randomized Controlled Trial.
Abstract Approximately 90% of low back pain (LBP) diagnoses are non-specific (NSLBP; i.e. with unknown cause). In NSLBP patients, the hamstrings, iliopsoas, piriformis, and tensor fasciae latae are overactive due to weak hip abductor, extensor, and core muscles. Core stability is essential for proper load balance within the pelvis, spine, and kinetic chain, and core stability exercise (CSE) is an exercise treatment regimen for LBP conditions. We investigated how core stability and hip muscle stretching exercises affected NSLBP patients' physical function and activity. Patients were randomly allocated to three grou...
Source: The Tohoku Journal of Experimental Medicine - July 18, 2020 Category: Research Authors: Kim B, Yim J Tags: Tohoku J Exp Med Source Type: research

Sleep Disturbance of Evacuees in Minamisanriku Town after Great East Japan Earthquake: Risk Factors and Treatment.
Abstract In 2011, Minamisanriku Town lost all of its medical facilities during the Great East Japan Earthquake. Using 10,459 anonymized disaster medical records of affected people in Minamisanriku Town, we assessed the prevalence and risk factors of sleep disturbance, which is known to exacerbate non-communicable diseases (NCDs) and anxiety disorder. Because sleep disturbance is a part of mental health issues, we divided the patients into two groups: patients (n = 492) with mental health issues other than sleep disturbance and the remaining (n = 9,967) with other comorbidities. Out of 492 patients with mental heal...
Source: The Tohoku Journal of Experimental Medicine - July 18, 2020 Category: Research Authors: Nakamura Y, Suda T, Murakami A, Sasaki H, Tsuji I, Sugawara Y, Nishizawa M, Hatsugai K, Egawa S Tags: Tohoku J Exp Med Source Type: research

Scoping Review of Hospital Business Continuity Plans to Validate the Improvement after the 2011 Great East Japan Earthquake and Tsunami.
This study conducted a scoping review of the historical trend and regional differences in hospital BCPs to validate the improvement of the BCP concept based on our own experience at Tohoku University Hospital, which was affected by the 2011 Great East Japan Earthquake and Tsunami (GEJET). We searched PubMed by using keywords related to BCP and adapted 97 articles for our analysis. The number of articles on hospital BCPs has increased in the 2000s, especially after Hurricane Katrina in 2005. While there are regional specificity of hazards, there were many common topics and visions for BCP implementation, education, and dril...
Source: The Tohoku Journal of Experimental Medicine - July 11, 2020 Category: Research Authors: Sasaki H, Maruya H, Abe Y, Fujita M, Furukawa H, Fuda M, Kamei T, Yaegashi N, Tominaga T, Egawa S Tags: Tohoku J Exp Med Source Type: research

IgG4-Related Disease Complicated by Brain Parenchymal Lesions Successfully Treated with Corticosteroid Therapy: A Case Report.
Abstract Immunoglobulin G4 (IgG4)-related disease (IgG4-RD) is distinguished by the infiltration of IgG4-positive plasma cells in a variety of tissues and organs including the pancreas, salivary glands, retroperitoneal lesions, kidney, and lymph nodes with elevated serum IgG4 levels. Even so, central nervous system (CNS) lesions such as brain parenchymal lesions associated with IgG4-RD are scarce. So far, only six cases of IgG4-RD in relation with brain parenchymal lesions have been described, with its characteristics still being not clear. Here we have detailed a case of IgG4-RD with brain parenchymal lesions and...
Source: The Tohoku Journal of Experimental Medicine - July 11, 2020 Category: Research Authors: Temmoku J, Sato S, Matsumoto H, Fujita Y, Suzuki E, Yashiro-Furuya M, Matsuoka N, Asano T, Ito E, Nakatani-Enomoto S, Kobayashi H, Watanabe H, Hashimoto Y, Migita K Tags: Tohoku J Exp Med Source Type: research

Clinical Features of Disaster-Associated Direct Deaths during Recent Inland Earthquakes in Japan.
This study was a retrospective and observational study that explored the effect of natural disasters on direct death. Although research reports on disaster-related deaths are common, there are few reports of disaster-associated direct death caused by events, such as house collapses, fires, and sediment-related factors. The amendment of the Building Standards Law in 1981 has made Japanese building standards more stringent. We sought to examine the determinants of the number of disaster-associated direct deaths during recent inland earthquakes in Japan. Following 2016 Kumamoto earthquakes (April 14, 21:26 [magnitude (M) 6.5]...
Source: The Tohoku Journal of Experimental Medicine - July 11, 2020 Category: Research Authors: Naito H, Sueta D, Nakayama H, Araki E, Tanihara H, Kasaoka S, Tsujita K Tags: Tohoku J Exp Med Source Type: research

COVID-19 Pandemic: Can Maintaining Optimal Zinc Balance Enhance Host Resistance?
Abstract The novel coronavirus disease 2019 (COVID-19) is now officially declared as a pandemic by the World Health Organization (WHO), and most parts of the world are taking drastic measures to restrict human movements to contain the infection. Millions around the world are wondering, if there is anything that could be done, other than maintaining high personal hygiene, and be vigilant of the symptoms, to reduce the spread of the disease and chances of getting infected, or at least to lessen the burden of the disease, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The National and Int...
Source: The Tohoku Journal of Experimental Medicine - July 11, 2020 Category: Research Authors: Razzaque MS Tags: Tohoku J Exp Med Source Type: research

High Relapse Rate in Patients with Polymyalgia Rheumatica despite the Combination of Immunosuppressants and Prednisolone: A Single Center Experience of 89 patients.
Abstract Polymyalgia rheumatica (PMR) is an inflammatory disorder in the elderly and is characterized by pain in the shoulders and lower back. Previous studies from western countries have shown that relapse is frequent; however, there are only a few reports on the relapse rate in Japan. Here we examined the relapse rate, and sought to identify factors that predict recurrence in patients with PMR. Of 110 patients who fulfilled the Bird's criteria for PMR between May 2011 and June 2019, 21 patients were excluded, and the remaining 89 patients were followed up until July 2019. Relapse was defined when clinical sympto...
Source: The Tohoku Journal of Experimental Medicine - June 26, 2020 Category: Research Authors: Okazaki S, Watanabe R, Kondo H, Kudo M, Harigae H, Fujii H Tags: Tohoku J Exp Med Source Type: research

Serum Mannose-Binding Lectin Levels Are Correlated with the Disease Activity of Antineutrophil Cytoplasmic Antibody-Associated Vasculitis: A Single-Center Study.
In this study, we investigated whether serum MBL is associated with disease activity of AAV, which was measured by ELISA. Associations between serum MBL and AAV-specific indices, as well as clinical and laboratory data were assessed using Kendall's tau. Among the 80 patients, 42 (52.5%), 21 (26.3), and 17 (21.3%) patients were classified as microscopic polyangiitis (MPA), granulomatosis with polyangiitis (GPA), and eosinophilic granulomatosis with polyangiitis (EGPA), respectively. The median values of erythrocyte sedimentation rate, C-reactive protein, and serum MBL were 36.5 (normal range
Source: The Tohoku Journal of Experimental Medicine - June 26, 2020 Category: Research Authors: Yoon T, Ahn SS, Yoo J, Yoo BW, Kwon HC, Jung SM, Song JJ, Park YB, Lee SW Tags: Tohoku J Exp Med Source Type: research

Impressions of Interfaith Chaplain's Activities among Patients in a Palliative Care Unit: A Semi-Structured Interview-Based Qualitative Study.
In conclusion, the interfaith chaplain is deemed helpful by the interviewed patients in relieving their anxieties. PMID: 32581192 [PubMed - in process] (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - June 26, 2020 Category: Research Authors: Hiratsuka Y, Aoyama M, Kaneta T, Masukawa K, Tagami K, Miyashita M, Inoue A Tags: Tohoku J Exp Med Source Type: research

Design and Progress of Oral Health Examinations in the Tohoku Medical Megabank Project.
i T, Ogishima S, Nakamura T, Sakurai-Yageta M, Nagami F, Kinoshita K, Kure S, Shimizu R, Sasaki K, Yamamoto M Abstract In order to assess the long-term impact of the Great East Japan Earthquake on the oral health of disaster victims and to evaluate gene-environmental interactions in the development of major oral diseases and oral-systemic associations, the oral part of two large-scale genome cohort studies by the Tohoku Medical Megabank Organization (ToMMo), including the Community-based cohort (CommCohort) study and the Birth and Three-Generation cohort (BirThree) study, have been conducted. The study population ...
Source: The Tohoku Journal of Experimental Medicine - June 26, 2020 Category: Research Authors: Tsuboi A, Matsui H, Shiraishi N, Murakami T, Otsuki A, Kawashima J, Kiyama T, Tamahara T, Goto M, Koyama S, Sugawara J, Kodama EN, Metoki H, Hozawa A, Kuriyama S, Tomita H, Kikuya M, Minegishi N, Suzuki K, Koshiba S, Tamiya G, Fuse N, Aoki Y, Takai-Igaras Tags: Tohoku J Exp Med Source Type: research

Uric Acid Elevation by Favipiravir, an Antiviral Drug.
Abstract In light of the recent pandemic, favipiravir (Avigan®), a purine nucleic acid analog and antiviral agent approved for use in influenza in Japan, is being studied for the treatment of coronavirus disease 2019 (COVID-19). Increase in blood uric acid level is a frequent side effect of favipiravir. Here, we discussed the mechanism of blood uric acid elevation during favipiravir treatment. Favipiravir is metabolized to an inactive metabolite M1 by aldehyde oxidase and xanthine oxidase, and excreted into urine. In the kidney, uric acid handling is regulated by the balance of reabsorption and tubular secreti...
Source: The Tohoku Journal of Experimental Medicine - June 18, 2020 Category: Research Authors: Mishima E, Anzai N, Miyazaki M, Abe T Tags: Tohoku J Exp Med Source Type: research

Successful Anti-TNF-Alpha Therapy for Crohn's Disease After Allogeneic Stem Cell Transplantation: A Case Report.
Abstract Graft-versus-host disease (GVHD) is a potentially life-threatening complication of allogeneic stem cell transplantation (Allo-SCT). Chronic GVHD, which typically presents more than 100 days after Allo-SCT, can resemble manifestations of autoimmune disease; however, there are only a few reports on the development of Crohn's disease (CD) after Allo-SCT. Here, we report a case of steroid-refractory CD after umbilical cord blood transplantation (CBT), which was dramatically improved with administration of anti-tumor necrosis factor-alpha (anti-TNF-alpha) antibodies. A 21-year-old woman with refractory Hodgkin...
Source: The Tohoku Journal of Experimental Medicine - June 9, 2020 Category: Research Authors: Kamachi K, Ando T, Tsuruoka N, Hashiguchi M, Kidoguchi K, Kusaba K, Sano H, Sano H, Yamaguchi K, Nishioka A, Yoshimura M, Yokoo M, Kubota Y, Kojima K, Kimura S Tags: Tohoku J Exp Med Source Type: research

Cardiac Resynchronization Therapy for Improving Non-Uniform Thickening of Left Ventricular Wall: Assessment by Quantitative Gated Myocardial Perfusion SPECT.
In conclusion, CRT improved non-uniformity of wall thickening between the LV septal and lateral regions evaluated using QGS, which is predictive of better prognosis in the chronic phase after CRT. PMID: 32493869 [PubMed - in process] (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - June 6, 2020 Category: Research Authors: Wakayama Y, Nakano M, Fukuda K, Kumagai K, Sugai Y, Hirose M, Yamaguchi N, Kondo M, Kaneta T, Fukuda H, Kagaya Y, Shimokawa H Tags: Tohoku J Exp Med Source Type: research

Cholesterol Emboli Co-Existing with Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis in a 76-Year-Old Woman.
We report a case of ANCA-associated vasculitis coexisting with cholesterol emboli. A 76-year-old woman was diagnosed with ANCA-associated interstitial pneumonitis. She rapidly developed progressive glomerulonephritis, purpura, and peripheral sensory nerve disorder. A kidney biopsy revealed that renal dysfunction was caused by vasculitis of the interlobular arteries and cholesterol emboli. A skin biopsy revealed that purpura was caused by cholesterol emboli. Glucocorticoid and statin therapies were administered. Thereafter, the renal function and other symptoms improved and stabilized. The representative symptoms of ANCA-as...
Source: The Tohoku Journal of Experimental Medicine - June 2, 2020 Category: Research Authors: Kojima R, Harada M, Yamaguchi A, Hashimoto K, Kamijo Y Tags: Tohoku J Exp Med Source Type: research

COVID-19 Waves: Importance of Accumulative Mortality per Million Inhabitants.
Abstract The reported number of new cases underestimates the real spread of COVID-19 pandemic because of non-tested asymptomatic people and limited global access to reliable diagnostic tests. In this context, COVID-19 mortality with confirmed diagnosis becomes an attractive source of information to be included in the analysis of perspectives and proposals. Objective data are required to calculate the capacity of resources provided by health systems. New strategies are needed to stabilize or minimize the mortality surge. However, we will not afford this goal until more alternatives were available. We still need an ...
Source: The Tohoku Journal of Experimental Medicine - May 30, 2020 Category: Research Authors: Delgado CA, Shimabuku RL, Chiroque-Solano PM Tags: Tohoku J Exp Med Source Type: research

Association between Adult Height and Risk of Lung Cancer Incidence among Japanese Men: The Miyagi Cohort Study.
Abstract It is already known that adult height is a factor associated with an increased risk of colon cancer and postmenopausal breast cancer, pancreatic cancer, premenopausal breast cancer, and ovarian cancer. However, the association between adult height and lung cancer incidence remains unclear. The purpose of the present study was to examine the association between adult height and the risk of lung cancer incidence in the Japanese population. We analyzed data for 43,743 men and women who were 40-64 years old at the baseline in 1990. We divided the participants into quintiles based on height at the baseline. Co...
Source: The Tohoku Journal of Experimental Medicine - May 30, 2020 Category: Research Authors: Mugikura M, Sugawara Y, Tomata Y, Kanemura S, Fukao A, Tsuji I Tags: Tohoku J Exp Med Source Type: research

Protease Inhibitors: Candidate Drugs to Inhibit Severe Acute Respiratory Syndrome Coronavirus 2 Replication.
Abstract The number of patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly increased, although the WHO declared a pandemic. However, drugs that function against SARS-CoV-2 have not been established. SARS-CoV-2 has been suggested to bind angiotensin-converting enzyme 2, the receptor of the SARS coronavirus. SARS coronavirus and coronavirus 229E, the cause of the common cold, replicate through cell-surface and endosomal pathways using a protease, the type II transmembrane protease. To examine the effects of protease inhibitors on the replication of coronavirus 229E, we pre...
Source: The Tohoku Journal of Experimental Medicine - May 27, 2020 Category: Research Authors: Yamaya M, Nishimura H, Deng X, Kikuchi A, Nagatomi R Tags: Tohoku J Exp Med Source Type: research

Higher Incidence of Syphilis among Patients with HIV Infection: Population Study using Surveillance Data of Tokyo, Japan.
The objective of this study was to evaluate the risk of HIV infection for syphilis co-infection on the population of Tokyo, Japan. We analyzed data of syphilis cases obtained from additional surveillance by the Tokyo Metropolitan Government in 2018, including those with human immunodeficiency virus (HIV) infection as well as data of HIV/acquired immunodeficiency syndrome (AIDS) cases during 1985-2017. We calculated the incidence of symptomatic syphilis cases among HIV-infected or non-HIV-infected individuals. Similarly, we calculated the incidence of syphilis, including asymptomatic cases, among each population. The relati...
Source: The Tohoku Journal of Experimental Medicine - May 27, 2020 Category: Research Authors: Sugishita Y, Kurita J, Sugawara T, Ohkusa Y Tags: Tohoku J Exp Med Source Type: research

Differences in the Magnitude of Motor Skill Acquisition and Interlimb Transfer between Left- and Right-Handed Subjects after Short-Term Unilateral Motor Skill Practice.
In conclusion, our results add to the body of literature by detecting the differences in the magnitude of motor skill acquisition and interlimb transfer between left- and right-handed subjects after short-term unilateral motor skill practice. PMID: 32434999 [PubMed - in process] (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - May 23, 2020 Category: Research Authors: Wang YF, Zhao J, Negyesi J, Nagatomi R Tags: Tohoku J Exp Med Source Type: research

Preceding Poor Physical Function Is Associated with New-Onset Musculoskeletal Pain among Older Natural Disaster Survivors: A Longitudinal Study after the Great East Japan Earthquake.
This study aimed to elucidate the association of poor physical function with new-onset musculoskeletal pain among older survivors after the Great East Japan Earthquake (GEJE). Survivors aged ≥ 65 years, 3 years after the GEJE, were assessed longitudinally for 1 year (n = 646). Musculoskeletal pain was assessed using a self-reported questionnaire, and new-onset musculoskeletal pain was defined as absence and presence of pain at 3 years and 4 years, respectively, after the disaster. Physical function at 3 years after the disaster was assessed using the Kihon Checklist physical function score, which consists of 5 yes/no qu...
Source: The Tohoku Journal of Experimental Medicine - May 23, 2020 Category: Research Authors: Yabe Y, Hagiwara Y, Sekiguchi T, Sugawara Y, Tsuchiya M, Yoshida S, Sogi Y, Yano T, Onoki T, Takahashi T, Iwatsu J, Tsuji I, Itoi E Tags: Tohoku J Exp Med Source Type: research

Subcutaneous Tocilizumab Is Effective for Treatment of Elderly-Onset Rheumatoid Arthritis.
Abstract Rheumatoid arthritis (RA) is an autoimmune disease characterized by systemic articular and bone manifestations and its pathogenesis is driven by a complex network of proinflammatory cytokines, including tumor necrosis factor and interleukin (IL)-6. Treatment of rheumatoid arthritis (RA) has been standardized by the introduction of a treat-to-target approach. Subcutaneous tocilizumab (TCZ-SC) is a humanized anti-IL-6 receptor monoclonal antibody, and is widely used for refractory RA patients in the clinical settings. However, it remains unknown whether TCZ-SC shows effectiveness for elderly onset RA. The s...
Source: The Tohoku Journal of Experimental Medicine - May 16, 2020 Category: Research Authors: Kondo N, Fujisawa J, Endo N Tags: Tohoku J Exp Med Source Type: research

Physician Distribution by Specialty and Practice Setting: Findings in Japan in 2000, 2010 and 2016.
Abstract As the medical demand is projected to increase along with the population aging in Japan, the geographical distribution of physicians is a significant concern for society and policymakers. To implement effective measures on geographical physician distribution, this study aimed to describe and compare the distribution of physicians by specialty in 2000, 2010 and 2016 in Japan, and examine whether practice setting was associated with distribution. To quantify the geographical physician distribution by specialty, we calculated the Gini coefficients of physicians working at clinics or hospitals in 2000, 2010, ...
Source: The Tohoku Journal of Experimental Medicine - May 9, 2020 Category: Research Authors: Ikesu R, Miyawaki A, Kobayashi Y Tags: Tohoku J Exp Med Source Type: research

Public Relations and Communication Strategies in Construction of Large-Scale Cohorts and Biobank: Practice in the Tohoku Medical Megabank Project.
Abstract The Tohoku Medical Megabank Project was designed as part of the national reconstruction project for addressing the damage from the 2011 Great East Japan Earthquake. It is an integrated project involving the genome cohort study of 150,000 participants, integrated biobank construction, and multi-omics analyses. Public relations and communication activities emerged to be extremely important in the successful development of this project. To gain insights into the contributions of these activities, we divided the public relations and communication activities for the project into three phases based on the situa...
Source: The Tohoku Journal of Experimental Medicine - April 24, 2020 Category: Research Authors: Nagami F, Kuriki M, Koreeda S, Kageyama M, Shimizu O, Toda S, Hozawa A, Kuriyama S, Osumi N, Yamamoto M Tags: Tohoku J Exp Med Source Type: research