Pretreatment with Ranitidine Bismuth Citrate May Improve Success Rates of Helicobacter pylori Eradication: A Prospective, Randomized, Controlled and Open-Label Study
Tohoku J Exp Med. 2021;255(1):41-48. doi: 10.1620/tjem.255.41.ABSTRACTEffective Helicobacter pylori (H. pylori) eradication is a major public health concern; however, eradication failure rates with the standard triple therapy remain high. We aimed to investigate the effectiveness and tolerability of ranitidine bismuth citrate (RBC) pretreatment before standard triple therapy for H. pylori eradication. A prospective, randomized, controlled, and open-label clinical trial was conducted from June to December 2019. H. pylori eradication rate, safety, and tolerability were compared between the standard treatment group (esomepraz...
Source: The Tohoku Journal of Experimental Medicine - September 16, 2021 Category: Research Authors: Jin Young Yoon Min Seob Kwak Jung Won Jeon Jae Myung Cha Source Type: research

Enzymatic Changes in Red Blood Cells of Diamond-Blackfan Anemia
In this study, to confirm the universality of our data, we extended the analysis to seven RBC enzymes and GSH of 14 patients with Diamond-Blackfan anemia and performed a cross-analysis study using enzyme activity assay and recently reported proteome data. Statistical analysis revealed that both data exhibited high similarity, upregulation in the hexokinase and pentose-phosphate pathway, and downregulation in glycolytic enzymes such as phosphofructokinase and pyruvate kinase, in the RBCs obtained from the subjects with Diamond-Blackfan anemia. The only discrepancy between enzyme activity and proteome data was observed in gl...
Source: The Tohoku Journal of Experimental Medicine - September 16, 2021 Category: Research Authors: Taiju Utsugisawa Toshitaka Uchiyama Tsutomu Toki Keiko Shimojima-Yamamoto Shouichi Ohga Etsuro Ito Hitoshi Kanno Source Type: research

Pretreatment with Ranitidine Bismuth Citrate May Improve Success Rates of Helicobacter pylori Eradication: A Prospective, Randomized, Controlled and Open-Label Study
Tohoku J Exp Med. 2021;255(1):41-48. doi: 10.1620/tjem.255.41.ABSTRACTEffective Helicobacter pylori (H. pylori) eradication is a major public health concern; however, eradication failure rates with the standard triple therapy remain high. We aimed to investigate the effectiveness and tolerability of ranitidine bismuth citrate (RBC) pretreatment before standard triple therapy for H. pylori eradication. A prospective, randomized, controlled, and open-label clinical trial was conducted from June to December 2019. H. pylori eradication rate, safety, and tolerability were compared between the standard treatment group (esomepraz...
Source: The Tohoku Journal of Experimental Medicine - September 16, 2021 Category: Research Authors: Jin Young Yoon Min Seob Kwak Jung Won Jeon Jae Myung Cha Source Type: research

Enzymatic Changes in Red Blood Cells of Diamond-Blackfan Anemia
In this study, to confirm the universality of our data, we extended the analysis to seven RBC enzymes and GSH of 14 patients with Diamond-Blackfan anemia and performed a cross-analysis study using enzyme activity assay and recently reported proteome data. Statistical analysis revealed that both data exhibited high similarity, upregulation in the hexokinase and pentose-phosphate pathway, and downregulation in glycolytic enzymes such as phosphofructokinase and pyruvate kinase, in the RBCs obtained from the subjects with Diamond-Blackfan anemia. The only discrepancy between enzyme activity and proteome data was observed in gl...
Source: The Tohoku Journal of Experimental Medicine - September 16, 2021 Category: Research Authors: Taiju Utsugisawa Toshitaka Uchiyama Tsutomu Toki Keiko Shimojima-Yamamoto Shouichi Ohga Etsuro Ito Hitoshi Kanno Source Type: research

Pretreatment with Ranitidine Bismuth Citrate May Improve Success Rates of Helicobacter pylori Eradication: A Prospective, Randomized, Controlled and Open-Label Study
Tohoku J Exp Med. 2021;255(1):41-48. doi: 10.1620/tjem.255.41.ABSTRACTEffective Helicobacter pylori (H. pylori) eradication is a major public health concern; however, eradication failure rates with the standard triple therapy remain high. We aimed to investigate the effectiveness and tolerability of ranitidine bismuth citrate (RBC) pretreatment before standard triple therapy for H. pylori eradication. A prospective, randomized, controlled, and open-label clinical trial was conducted from June to December 2019. H. pylori eradication rate, safety, and tolerability were compared between the standard treatment group (esomepraz...
Source: The Tohoku Journal of Experimental Medicine - September 16, 2021 Category: Research Authors: Jin Young Yoon Min Seob Kwak Jung Won Jeon Jae Myung Cha Source Type: research

Enzymatic Changes in Red Blood Cells of Diamond-Blackfan Anemia
In this study, to confirm the universality of our data, we extended the analysis to seven RBC enzymes and GSH of 14 patients with Diamond-Blackfan anemia and performed a cross-analysis study using enzyme activity assay and recently reported proteome data. Statistical analysis revealed that both data exhibited high similarity, upregulation in the hexokinase and pentose-phosphate pathway, and downregulation in glycolytic enzymes such as phosphofructokinase and pyruvate kinase, in the RBCs obtained from the subjects with Diamond-Blackfan anemia. The only discrepancy between enzyme activity and proteome data was observed in gl...
Source: The Tohoku Journal of Experimental Medicine - September 16, 2021 Category: Research Authors: Taiju Utsugisawa Toshitaka Uchiyama Tsutomu Toki Keiko Shimojima-Yamamoto Shouichi Ohga Etsuro Ito Hitoshi Kanno Source Type: research

Pretreatment with Ranitidine Bismuth Citrate May Improve Success Rates of Helicobacter pylori Eradication: A Prospective, Randomized, Controlled and Open-Label Study
Tohoku J Exp Med. 2021;255(1):41-48. doi: 10.1620/tjem.255.41.ABSTRACTEffective Helicobacter pylori (H. pylori) eradication is a major public health concern; however, eradication failure rates with the standard triple therapy remain high. We aimed to investigate the effectiveness and tolerability of ranitidine bismuth citrate (RBC) pretreatment before standard triple therapy for H. pylori eradication. A prospective, randomized, controlled, and open-label clinical trial was conducted from June to December 2019. H. pylori eradication rate, safety, and tolerability were compared between the standard treatment group (esomepraz...
Source: The Tohoku Journal of Experimental Medicine - September 16, 2021 Category: Research Authors: Jin Young Yoon Min Seob Kwak Jung Won Jeon Jae Myung Cha Source Type: research

Enzymatic Changes in Red Blood Cells of Diamond-Blackfan Anemia
In this study, to confirm the universality of our data, we extended the analysis to seven RBC enzymes and GSH of 14 patients with Diamond-Blackfan anemia and performed a cross-analysis study using enzyme activity assay and recently reported proteome data. Statistical analysis revealed that both data exhibited high similarity, upregulation in the hexokinase and pentose-phosphate pathway, and downregulation in glycolytic enzymes such as phosphofructokinase and pyruvate kinase, in the RBCs obtained from the subjects with Diamond-Blackfan anemia. The only discrepancy between enzyme activity and proteome data was observed in gl...
Source: The Tohoku Journal of Experimental Medicine - September 16, 2021 Category: Research Authors: Taiju Utsugisawa Toshitaka Uchiyama Tsutomu Toki Keiko Shimojima-Yamamoto Shouichi Ohga Etsuro Ito Hitoshi Kanno Source Type: research

Pretreatment with Ranitidine Bismuth Citrate May Improve Success Rates of Helicobacter pylori Eradication: A Prospective, Randomized, Controlled and Open-Label Study
Tohoku J Exp Med. 2021;255(1):41-48. doi: 10.1620/tjem.255.41.ABSTRACTEffective Helicobacter pylori (H. pylori) eradication is a major public health concern; however, eradication failure rates with the standard triple therapy remain high. We aimed to investigate the effectiveness and tolerability of ranitidine bismuth citrate (RBC) pretreatment before standard triple therapy for H. pylori eradication. A prospective, randomized, controlled, and open-label clinical trial was conducted from June to December 2019. H. pylori eradication rate, safety, and tolerability were compared between the standard treatment group (esomepraz...
Source: The Tohoku Journal of Experimental Medicine - September 16, 2021 Category: Research Authors: Jin Young Yoon Min Seob Kwak Jung Won Jeon Jae Myung Cha Source Type: research

Enzymatic Changes in Red Blood Cells of Diamond-Blackfan Anemia
In this study, to confirm the universality of our data, we extended the analysis to seven RBC enzymes and GSH of 14 patients with Diamond-Blackfan anemia and performed a cross-analysis study using enzyme activity assay and recently reported proteome data. Statistical analysis revealed that both data exhibited high similarity, upregulation in the hexokinase and pentose-phosphate pathway, and downregulation in glycolytic enzymes such as phosphofructokinase and pyruvate kinase, in the RBCs obtained from the subjects with Diamond-Blackfan anemia. The only discrepancy between enzyme activity and proteome data was observed in gl...
Source: The Tohoku Journal of Experimental Medicine - September 16, 2021 Category: Research Authors: Taiju Utsugisawa Toshitaka Uchiyama Tsutomu Toki Keiko Shimojima-Yamamoto Shouichi Ohga Etsuro Ito Hitoshi Kanno Source Type: research

Coagulation, Protease-Activated Receptors, and Diabetic Kidney Disease: Lessons from eNOS-Deficient Mice
Tohoku J Exp Med. 2021;255(1):1-8. doi: 10.1620/tjem.255.1.ABSTRACTEndothelial nitric oxide synthase (eNOS) dysfunction is known to exacerbate the progression and prognosis of diabetic kidney disease (DKD). One of the mechanisms through which this is achieved is that low eNOS levels are associated with hypercoagulability, which promotes kidney injury. In the extrinsic coagulation cascade, the tissue factor (factor III) and downstream coagulation factors, such as active factor X (FXa), exacerbate inflammation through activation of the protease-activated receptors (PARs). Recently, it has been shown that the lack of or reduc...
Source: The Tohoku Journal of Experimental Medicine - September 13, 2021 Category: Research Authors: Yuji Oe Mariko Miyazaki Nobuyuki Takahashi Source Type: research

Clinical Course of Ulcerative Colitis Associated with an Age at Diagnosis: A Recent Japanese Database Survey
Tohoku J Exp Med. 2021;255(1):33-39. doi: 10.1620/tjem.255.33.ABSTRACTThe onset age of ulcerative colitis has been increasing in several countries. Furthermore, the number of elderly patients with ulcerative colitis has been increasing in an aging society. We investigated the incidence of ulcerative colitis patients in Japan using a large-scale health insurance claims database to survey the ulcerative colitis incidence ratio and the clinical characteristics in late-onset ulcerative colitis patients. Newly diagnosed 2,791 ulcerative colitis between 2015 and 2018 was investigated. Medical treatment within 12 months of diagno...
Source: The Tohoku Journal of Experimental Medicine - September 13, 2021 Category: Research Authors: Yosuke Shimodaira Kenta Watanabe Katsunori Iijima Source Type: research

Coagulation, Protease-Activated Receptors, and Diabetic Kidney Disease: Lessons from eNOS-Deficient Mice
Tohoku J Exp Med. 2021;255(1):1-8. doi: 10.1620/tjem.255.1.ABSTRACTEndothelial nitric oxide synthase (eNOS) dysfunction is known to exacerbate the progression and prognosis of diabetic kidney disease (DKD). One of the mechanisms through which this is achieved is that low eNOS levels are associated with hypercoagulability, which promotes kidney injury. In the extrinsic coagulation cascade, the tissue factor (factor III) and downstream coagulation factors, such as active factor X (FXa), exacerbate inflammation through activation of the protease-activated receptors (PARs). Recently, it has been shown that the lack of or reduc...
Source: The Tohoku Journal of Experimental Medicine - September 13, 2021 Category: Research Authors: Yuji Oe Mariko Miyazaki Nobuyuki Takahashi Source Type: research

Clinical Course of Ulcerative Colitis Associated with an Age at Diagnosis: A Recent Japanese Database Survey
Tohoku J Exp Med. 2021;255(1):33-39. doi: 10.1620/tjem.255.33.ABSTRACTThe onset age of ulcerative colitis has been increasing in several countries. Furthermore, the number of elderly patients with ulcerative colitis has been increasing in an aging society. We investigated the incidence of ulcerative colitis patients in Japan using a large-scale health insurance claims database to survey the ulcerative colitis incidence ratio and the clinical characteristics in late-onset ulcerative colitis patients. Newly diagnosed 2,791 ulcerative colitis between 2015 and 2018 was investigated. Medical treatment within 12 months of diagno...
Source: The Tohoku Journal of Experimental Medicine - September 13, 2021 Category: Research Authors: Yosuke Shimodaira Kenta Watanabe Katsunori Iijima Source Type: research

Coagulation, Protease-Activated Receptors, and Diabetic Kidney Disease: Lessons from eNOS-Deficient Mice
Tohoku J Exp Med. 2021;255(1):1-8. doi: 10.1620/tjem.255.1.ABSTRACTEndothelial nitric oxide synthase (eNOS) dysfunction is known to exacerbate the progression and prognosis of diabetic kidney disease (DKD). One of the mechanisms through which this is achieved is that low eNOS levels are associated with hypercoagulability, which promotes kidney injury. In the extrinsic coagulation cascade, the tissue factor (factor III) and downstream coagulation factors, such as active factor X (FXa), exacerbate inflammation through activation of the protease-activated receptors (PARs). Recently, it has been shown that the lack of or reduc...
Source: The Tohoku Journal of Experimental Medicine - September 13, 2021 Category: Research Authors: Yuji Oe Mariko Miyazaki Nobuyuki Takahashi Source Type: research

Clinical Course of Ulcerative Colitis Associated with an Age at Diagnosis: A Recent Japanese Database Survey
Tohoku J Exp Med. 2021;255(1):33-39. doi: 10.1620/tjem.255.33.ABSTRACTThe onset age of ulcerative colitis has been increasing in several countries. Furthermore, the number of elderly patients with ulcerative colitis has been increasing in an aging society. We investigated the incidence of ulcerative colitis patients in Japan using a large-scale health insurance claims database to survey the ulcerative colitis incidence ratio and the clinical characteristics in late-onset ulcerative colitis patients. Newly diagnosed 2,791 ulcerative colitis between 2015 and 2018 was investigated. Medical treatment within 12 months of diagno...
Source: The Tohoku Journal of Experimental Medicine - September 13, 2021 Category: Research Authors: Yosuke Shimodaira Kenta Watanabe Katsunori Iijima Source Type: research

Coagulation, Protease-Activated Receptors, and Diabetic Kidney Disease: Lessons from eNOS-Deficient Mice
Tohoku J Exp Med. 2021;255(1):1-8. doi: 10.1620/tjem.255.1.ABSTRACTEndothelial nitric oxide synthase (eNOS) dysfunction is known to exacerbate the progression and prognosis of diabetic kidney disease (DKD). One of the mechanisms through which this is achieved is that low eNOS levels are associated with hypercoagulability, which promotes kidney injury. In the extrinsic coagulation cascade, the tissue factor (factor III) and downstream coagulation factors, such as active factor X (FXa), exacerbate inflammation through activation of the protease-activated receptors (PARs). Recently, it has been shown that the lack of or reduc...
Source: The Tohoku Journal of Experimental Medicine - September 13, 2021 Category: Research Authors: Yuji Oe Mariko Miyazaki Nobuyuki Takahashi Source Type: research

Clinical Course of Ulcerative Colitis Associated with an Age at Diagnosis: A Recent Japanese Database Survey
Tohoku J Exp Med. 2021;255(1):33-39. doi: 10.1620/tjem.255.33.ABSTRACTThe onset age of ulcerative colitis has been increasing in several countries. Furthermore, the number of elderly patients with ulcerative colitis has been increasing in an aging society. We investigated the incidence of ulcerative colitis patients in Japan using a large-scale health insurance claims database to survey the ulcerative colitis incidence ratio and the clinical characteristics in late-onset ulcerative colitis patients. Newly diagnosed 2,791 ulcerative colitis between 2015 and 2018 was investigated. Medical treatment within 12 months of diagno...
Source: The Tohoku Journal of Experimental Medicine - September 13, 2021 Category: Research Authors: Yosuke Shimodaira Kenta Watanabe Katsunori Iijima Source Type: research

Coagulation, Protease-Activated Receptors, and Diabetic Kidney Disease: Lessons from eNOS-Deficient Mice
Tohoku J Exp Med. 2021;255(1):1-8. doi: 10.1620/tjem.255.1.ABSTRACTEndothelial nitric oxide synthase (eNOS) dysfunction is known to exacerbate the progression and prognosis of diabetic kidney disease (DKD). One of the mechanisms through which this is achieved is that low eNOS levels are associated with hypercoagulability, which promotes kidney injury. In the extrinsic coagulation cascade, the tissue factor (factor III) and downstream coagulation factors, such as active factor X (FXa), exacerbate inflammation through activation of the protease-activated receptors (PARs). Recently, it has been shown that the lack of or reduc...
Source: The Tohoku Journal of Experimental Medicine - September 13, 2021 Category: Research Authors: Yuji Oe Mariko Miyazaki Nobuyuki Takahashi Source Type: research

Clinical Course of Ulcerative Colitis Associated with an Age at Diagnosis: A Recent Japanese Database Survey
Tohoku J Exp Med. 2021;255(1):33-39. doi: 10.1620/tjem.255.33.ABSTRACTThe onset age of ulcerative colitis has been increasing in several countries. Furthermore, the number of elderly patients with ulcerative colitis has been increasing in an aging society. We investigated the incidence of ulcerative colitis patients in Japan using a large-scale health insurance claims database to survey the ulcerative colitis incidence ratio and the clinical characteristics in late-onset ulcerative colitis patients. Newly diagnosed 2,791 ulcerative colitis between 2015 and 2018 was investigated. Medical treatment within 12 months of diagno...
Source: The Tohoku Journal of Experimental Medicine - September 13, 2021 Category: Research Authors: Yosuke Shimodaira Kenta Watanabe Katsunori Iijima Source Type: research

Coagulation, Protease-Activated Receptors, and Diabetic Kidney Disease: Lessons from eNOS-Deficient Mice
Tohoku J Exp Med. 2021;255(1):1-8. doi: 10.1620/tjem.255.1.ABSTRACTEndothelial nitric oxide synthase (eNOS) dysfunction is known to exacerbate the progression and prognosis of diabetic kidney disease (DKD). One of the mechanisms through which this is achieved is that low eNOS levels are associated with hypercoagulability, which promotes kidney injury. In the extrinsic coagulation cascade, the tissue factor (factor III) and downstream coagulation factors, such as active factor X (FXa), exacerbate inflammation through activation of the protease-activated receptors (PARs). Recently, it has been shown that the lack of or reduc...
Source: The Tohoku Journal of Experimental Medicine - September 13, 2021 Category: Research Authors: Yuji Oe Mariko Miyazaki Nobuyuki Takahashi Source Type: research

Clinical Course of Ulcerative Colitis Associated with an Age at Diagnosis: A Recent Japanese Database Survey
Tohoku J Exp Med. 2021;255(1):33-39. doi: 10.1620/tjem.255.33.ABSTRACTThe onset age of ulcerative colitis has been increasing in several countries. Furthermore, the number of elderly patients with ulcerative colitis has been increasing in an aging society. We investigated the incidence of ulcerative colitis patients in Japan using a large-scale health insurance claims database to survey the ulcerative colitis incidence ratio and the clinical characteristics in late-onset ulcerative colitis patients. Newly diagnosed 2,791 ulcerative colitis between 2015 and 2018 was investigated. Medical treatment within 12 months of diagno...
Source: The Tohoku Journal of Experimental Medicine - September 13, 2021 Category: Research Authors: Yosuke Shimodaira Kenta Watanabe Katsunori Iijima Source Type: research

Toxicological Effects of Artificial Fine Particulate Matter in Rats through Induction of Oxidative Stress and Inflammation
Tohoku J Exp Med. 2021 Sep;255(1):19-25. doi: 10.1620/tjem.255.19.ABSTRACTAirborne fine particulate matter with an aerodynamic diameter equal to or smaller than 2.5 μm (abbreviated as PM2.5) increases the risk of nasal lesions, but the underlying molecular mechanism has not been fully elucidated. In the atmosphere, the composition of PM2.5 collected varies in physical and chemical properties, which affects its damage to human health. Thus, we constructed artificial PM2.5 particles based on actual PM2.5 and investigated the in vivo effects of artificial PM2.5 exposure on the oxidative stress, inflammatory response, and n...
Source: The Tohoku Journal of Experimental Medicine - September 9, 2021 Category: Research Authors: Zhicong Hong Peiji Zeng Guoshun Zhuang Qiaoling Guo Chengfu Cai Source Type: research

The Expression of Insulin-Like Growth Factor 2 Messenger RNA-Binding Protein 3 in Langerhans Cell Histiocytosis and Langerhans Cell Sarcoma
Tohoku J Exp Med. 2021 Sep;255(1):27-31. doi: 10.1620/tjem.255.27.ABSTRACTLangerhans cell neoplasms, which include Langerhans cell histiocytosis and Langerhans cell sarcoma, are tumors that originate from dendritic cells. Langerhans cell sarcoma is defined as a high-grade neoplasm with overtly malignant cytological features and the Langerhans cell-like phenotype, and generally has a poorer prognosis and more aggressive phenotype than Langerhans cell histiocytosis. Insulin-like growth factor 2 messenger RNA-binding protein 3 (IGF2BP3 or IMP3) is an oncofetal protein that is expressed in various cancer types; its expression ...
Source: The Tohoku Journal of Experimental Medicine - September 9, 2021 Category: Research Authors: Konomi Yashige Tatsuki R Kataoka Yosuke Yamada Hirona Maeda Marina Oji-Tsujimura Tetsurou Yamamoto Yusuke Takei Koki Moriyoshi Kazuo Ono Yo Kaku Tetsuya Tabata Ichiro Murakami Hirokazu Nakamine Hironori Haga Source Type: research

Knowledge, Experience, and Perceptions of Generic Drugs among Middle-Aged Adults and their Willingness-to-Pay: A Nationwide Online Survey in Japan
Tohoku J Exp Med. 2021 Sep;255(1):9-17. doi: 10.1620/tjem.255.9.ABSTRACTPromoting generic drugs can reduce the financial burden on patients and improve healthcare finances. The insurers have been conducting promotional efforts, such as direct-mail campaigns, but little is known about the public's perception of generic drugs and effective message strategies for promotion. In 2018, we conducted a web-based survey of middle-aged Japanese men and women that investigated: (i) their perceptions of generic drugs, (ii) the association between perceptions and willingness-to-pay for brand-name drugs relative to generic drugs, and (i...
Source: The Tohoku Journal of Experimental Medicine - September 9, 2021 Category: Research Authors: Yuki Ito Konan Hara Hajime Sato Jun Tomio Source Type: research

Toxicological Effects of Artificial Fine Particulate Matter in Rats through Induction of Oxidative Stress and Inflammation
Tohoku J Exp Med. 2021 Sep;255(1):19-25. doi: 10.1620/tjem.255.19.ABSTRACTAirborne fine particulate matter with an aerodynamic diameter equal to or smaller than 2.5 μm (abbreviated as PM2.5) increases the risk of nasal lesions, but the underlying molecular mechanism has not been fully elucidated. In the atmosphere, the composition of PM2.5 collected varies in physical and chemical properties, which affects its damage to human health. Thus, we constructed artificial PM2.5 particles based on actual PM2.5 and investigated the in vivo effects of artificial PM2.5 exposure on the oxidative stress, inflammatory response, and n...
Source: The Tohoku Journal of Experimental Medicine - September 9, 2021 Category: Research Authors: Zhicong Hong Peiji Zeng Guoshun Zhuang Qiaoling Guo Chengfu Cai Source Type: research

The Expression of Insulin-Like Growth Factor 2 Messenger RNA-Binding Protein 3 in Langerhans Cell Histiocytosis and Langerhans Cell Sarcoma
Tohoku J Exp Med. 2021 Sep;255(1):27-31. doi: 10.1620/tjem.255.27.ABSTRACTLangerhans cell neoplasms, which include Langerhans cell histiocytosis and Langerhans cell sarcoma, are tumors that originate from dendritic cells. Langerhans cell sarcoma is defined as a high-grade neoplasm with overtly malignant cytological features and the Langerhans cell-like phenotype, and generally has a poorer prognosis and more aggressive phenotype than Langerhans cell histiocytosis. Insulin-like growth factor 2 messenger RNA-binding protein 3 (IGF2BP3 or IMP3) is an oncofetal protein that is expressed in various cancer types; its expression ...
Source: The Tohoku Journal of Experimental Medicine - September 9, 2021 Category: Research Authors: Konomi Yashige Tatsuki R Kataoka Yosuke Yamada Hirona Maeda Marina Oji-Tsujimura Tetsurou Yamamoto Yusuke Takei Koki Moriyoshi Kazuo Ono Yo Kaku Tetsuya Tabata Ichiro Murakami Hirokazu Nakamine Hironori Haga Source Type: research

Knowledge, Experience, and Perceptions of Generic Drugs among Middle-Aged Adults and their Willingness-to-Pay: A Nationwide Online Survey in Japan
Tohoku J Exp Med. 2021 Sep;255(1):9-17. doi: 10.1620/tjem.255.9.ABSTRACTPromoting generic drugs can reduce the financial burden on patients and improve healthcare finances. The insurers have been conducting promotional efforts, such as direct-mail campaigns, but little is known about the public's perception of generic drugs and effective message strategies for promotion. In 2018, we conducted a web-based survey of middle-aged Japanese men and women that investigated: (i) their perceptions of generic drugs, (ii) the association between perceptions and willingness-to-pay for brand-name drugs relative to generic drugs, and (i...
Source: The Tohoku Journal of Experimental Medicine - September 9, 2021 Category: Research Authors: Yuki Ito Konan Hara Hajime Sato Jun Tomio Source Type: research

Toxicological Effects of Artificial Fine Particulate Matter in Rats through Induction of Oxidative Stress and Inflammation
Tohoku J Exp Med. 2021 Sep;255(1):19-25. doi: 10.1620/tjem.255.19.ABSTRACTAirborne fine particulate matter with an aerodynamic diameter equal to or smaller than 2.5 μm (abbreviated as PM2.5) increases the risk of nasal lesions, but the underlying molecular mechanism has not been fully elucidated. In the atmosphere, the composition of PM2.5 collected varies in physical and chemical properties, which affects its damage to human health. Thus, we constructed artificial PM2.5 particles based on actual PM2.5 and investigated the in vivo effects of artificial PM2.5 exposure on the oxidative stress, inflammatory response, and n...
Source: The Tohoku Journal of Experimental Medicine - September 9, 2021 Category: Research Authors: Zhicong Hong Peiji Zeng Guoshun Zhuang Qiaoling Guo Chengfu Cai Source Type: research

The Expression of Insulin-Like Growth Factor 2 Messenger RNA-Binding Protein 3 in Langerhans Cell Histiocytosis and Langerhans Cell Sarcoma
Tohoku J Exp Med. 2021 Sep;255(1):27-31. doi: 10.1620/tjem.255.27.ABSTRACTLangerhans cell neoplasms, which include Langerhans cell histiocytosis and Langerhans cell sarcoma, are tumors that originate from dendritic cells. Langerhans cell sarcoma is defined as a high-grade neoplasm with overtly malignant cytological features and the Langerhans cell-like phenotype, and generally has a poorer prognosis and more aggressive phenotype than Langerhans cell histiocytosis. Insulin-like growth factor 2 messenger RNA-binding protein 3 (IGF2BP3 or IMP3) is an oncofetal protein that is expressed in various cancer types; its expression ...
Source: The Tohoku Journal of Experimental Medicine - September 9, 2021 Category: Research Authors: Konomi Yashige Tatsuki R Kataoka Yosuke Yamada Hirona Maeda Marina Oji-Tsujimura Tetsurou Yamamoto Yusuke Takei Koki Moriyoshi Kazuo Ono Yo Kaku Tetsuya Tabata Ichiro Murakami Hirokazu Nakamine Hironori Haga Source Type: research

Knowledge, Experience, and Perceptions of Generic Drugs among Middle-Aged Adults and their Willingness-to-Pay: A Nationwide Online Survey in Japan
Tohoku J Exp Med. 2021 Sep;255(1):9-17. doi: 10.1620/tjem.255.9.ABSTRACTPromoting generic drugs can reduce the financial burden on patients and improve healthcare finances. The insurers have been conducting promotional efforts, such as direct-mail campaigns, but little is known about the public's perception of generic drugs and effective message strategies for promotion. In 2018, we conducted a web-based survey of middle-aged Japanese men and women that investigated: (i) their perceptions of generic drugs, (ii) the association between perceptions and willingness-to-pay for brand-name drugs relative to generic drugs, and (i...
Source: The Tohoku Journal of Experimental Medicine - September 9, 2021 Category: Research Authors: Yuki Ito Konan Hara Hajime Sato Jun Tomio Source Type: research

Toxicological Effects of Artificial Fine Particulate Matter in Rats through Induction of Oxidative Stress and Inflammation
Tohoku J Exp Med. 2021;255(1):19-25. doi: 10.1620/tjem.255.19.ABSTRACTAirborne fine particulate matter with an aerodynamic diameter equal to or smaller than 2.5 μm (abbreviated as PM2.5) increases the risk of nasal lesions, but the underlying molecular mechanism has not been fully elucidated. In the atmosphere, the composition of PM2.5 collected varies in physical and chemical properties, which affects its damage to human health. Thus, we constructed artificial PM2.5 particles based on actual PM2.5 and investigated the in vivo effects of artificial PM2.5 exposure on the oxidative stress, inflammatory response, and nasal...
Source: The Tohoku Journal of Experimental Medicine - September 9, 2021 Category: Research Authors: Zhicong Hong Peiji Zeng Guoshun Zhuang Qiaoling Guo Chengfu Cai Source Type: research

The Expression of Insulin-Like Growth Factor 2 Messenger RNA-Binding Protein 3 in Langerhans Cell Histiocytosis and Langerhans Cell Sarcoma
Tohoku J Exp Med. 2021;255(1):27-31. doi: 10.1620/tjem.255.27.ABSTRACTLangerhans cell neoplasms, which include Langerhans cell histiocytosis and Langerhans cell sarcoma, are tumors that originate from dendritic cells. Langerhans cell sarcoma is defined as a high-grade neoplasm with overtly malignant cytological features and the Langerhans cell-like phenotype, and generally has a poorer prognosis and more aggressive phenotype than Langerhans cell histiocytosis. Insulin-like growth factor 2 messenger RNA-binding protein 3 (IGF2BP3 or IMP3) is an oncofetal protein that is expressed in various cancer types; its expression is o...
Source: The Tohoku Journal of Experimental Medicine - September 9, 2021 Category: Research Authors: Konomi Yashige Tatsuki R Kataoka Yosuke Yamada Hirona Maeda Marina Oji-Tsujimura Tetsurou Yamamoto Yusuke Takei Koki Moriyoshi Kazuo Ono Yo Kaku Tetsuya Tabata Ichiro Murakami Hirokazu Nakamine Hironori Haga Source Type: research

Knowledge, Experience, and Perceptions of Generic Drugs among Middle-Aged Adults and their Willingness-to-Pay: A Nationwide Online Survey in Japan
Tohoku J Exp Med. 2021;255(1):9-17. doi: 10.1620/tjem.255.9.ABSTRACTPromoting generic drugs can reduce the financial burden on patients and improve healthcare finances. The insurers have been conducting promotional efforts, such as direct-mail campaigns, but little is known about the public's perception of generic drugs and effective message strategies for promotion. In 2018, we conducted a web-based survey of middle-aged Japanese men and women that investigated: (i) their perceptions of generic drugs, (ii) the association between perceptions and willingness-to-pay for brand-name drugs relative to generic drugs, and (iii) ...
Source: The Tohoku Journal of Experimental Medicine - September 9, 2021 Category: Research Authors: Yuki Ito Konan Hara Hajime Sato Jun Tomio Source Type: research

Role of Early Mobilization on the Clinical Course of Patients who Underwent Pancreaticoduodenectomy: A Retrospective Cohort Study
This study aimed to examine the impact of the initial ambulation day, which is one of the components of early mobilization, on LOS after pancreaticoduodenectomy. We retrospectively enrolled patients who underwent pancreaticoduodenectomy between January 2013 and December 2017. Postoperative complications were evaluated using the Clavien-Dindo classification (CDC) system. Patients were divided into two groups based on the median LOS (early and late-discharge groups) and compared to determine their characteristics. Multivariate logistic regression analysis was performed with LOS as the dependent variable. Patients in the late...
Source: The Tohoku Journal of Experimental Medicine - August 30, 2021 Category: Research Authors: Takuya Fukushima Tomohiko Adachi Masatoshi Hanada Takayuki Tanaka Masato Oikawa Hiroki Nagura Susumu Eguchi Ryo Kozu Source Type: research

Role of Early Mobilization on the Clinical Course of Patients who Underwent Pancreaticoduodenectomy: A Retrospective Cohort Study
This study aimed to examine the impact of the initial ambulation day, which is one of the components of early mobilization, on LOS after pancreaticoduodenectomy. We retrospectively enrolled patients who underwent pancreaticoduodenectomy between January 2013 and December 2017. Postoperative complications were evaluated using the Clavien-Dindo classification (CDC) system. Patients were divided into two groups based on the median LOS (early and late-discharge groups) and compared to determine their characteristics. Multivariate logistic regression analysis was performed with LOS as the dependent variable. Patients in the late...
Source: The Tohoku Journal of Experimental Medicine - August 30, 2021 Category: Research Authors: Takuya Fukushima Tomohiko Adachi Masatoshi Hanada Takayuki Tanaka Masato Oikawa Hiroki Nagura Susumu Eguchi Ryo Kozu Source Type: research

Nephrotoxicity of Immune Checkpoint Inhibitors: A Disproportionality Analysis from 2013 to 2020
This study aimed to systematically characterize nephrotoxicity after ICI initiation. Data were extracted from the US FDA Adverse Event Reporting System (FAERS) database. Disproportionality analysis, including information components (ICs) and reporting odds ratios (RORs), was performed to determine the potential renal toxicity of ICIs. A total of 7,204 reports of renal adverse events (AEs) were identified in the FAERS database. Renal AEs were most commonly reported for nivolumab (46.84%). Strong signals were detected in male patients combined with ICIs. In the clinical application of ICIs, attention should be paid to patien...
Source: The Tohoku Journal of Experimental Medicine - August 26, 2021 Category: Research Authors: Jiaming Qu Yanming Ding Kaiwen Jiang Junxia Hao Yuanzhi Li Aijun Zhang Zhaohang Li Guanpeng Qi Ze Xu Xin Liu Juman Ma Kaishun Bi Zuojing Li Source Type: research

Beh çet's Disease with Extremely High Levels of Urinary β2-Microglobulin after Non-Steroidal Anti-Inflammatory Drug Treatment
Tohoku J Exp Med. 2021;254(4):283-286. doi: 10.1620/tjem.254.283.ABSTRACTBehçet's disease is an inflammatory disease which manifests itself as various symptoms, such as uveitis, oral and genital aphthae, erythema nodosa, gastro-intestinal ulcerations and encephalopathy. Among the manifestations, renal dysfunction is reported in some percentage of the patients with this disorder. We experienced a middle-aged male with Behçet's disease who showed an extremely high level of urinary β2-microglulin, which is one of the markers of renal dysfunction, despite normal serum creatinine levels. The patient was on no...
Source: The Tohoku Journal of Experimental Medicine - August 26, 2021 Category: Research Authors: Ryohei Ogino Karin Shimada Daiki Narai Masanori Goto Katsuhiro Sato Yoshihisa Katsuta Akimasa Shiigi Juri Ueda Chika Oyama Yuko Fujikawa Isabelle Miyazawa Takahiro Ohara Kazuhiro Sumitomo Shigeru Sato Nobuo Koinuma Atsuhiro Kanno Katsutoshi Furukawa Source Type: research

Nephrotoxicity of Immune Checkpoint Inhibitors: A Disproportionality Analysis from 2013 to 2020
This study aimed to systematically characterize nephrotoxicity after ICI initiation. Data were extracted from the US FDA Adverse Event Reporting System (FAERS) database. Disproportionality analysis, including information components (ICs) and reporting odds ratios (RORs), was performed to determine the potential renal toxicity of ICIs. A total of 7,204 reports of renal adverse events (AEs) were identified in the FAERS database. Renal AEs were most commonly reported for nivolumab (46.84%). Strong signals were detected in male patients combined with ICIs. In the clinical application of ICIs, attention should be paid to patien...
Source: The Tohoku Journal of Experimental Medicine - August 26, 2021 Category: Research Authors: Jiaming Qu Yanming Ding Kaiwen Jiang Junxia Hao Yuanzhi Li Aijun Zhang Zhaohang Li Guanpeng Qi Ze Xu Xin Liu Juman Ma Kaishun Bi Zuojing Li Source Type: research

Beh çet's Disease with Extremely High Levels of Urinary β2-Microglobulin after Non-Steroidal Anti-Inflammatory Drug Treatment
Tohoku J Exp Med. 2021;254(4):283-286. doi: 10.1620/tjem.254.283.ABSTRACTBehçet's disease is an inflammatory disease which manifests itself as various symptoms, such as uveitis, oral and genital aphthae, erythema nodosa, gastro-intestinal ulcerations and encephalopathy. Among the manifestations, renal dysfunction is reported in some percentage of the patients with this disorder. We experienced a middle-aged male with Behçet's disease who showed an extremely high level of urinary β2-microglulin, which is one of the markers of renal dysfunction, despite normal serum creatinine levels. The patient was on no...
Source: The Tohoku Journal of Experimental Medicine - August 26, 2021 Category: Research Authors: Ryohei Ogino Karin Shimada Daiki Narai Masanori Goto Katsuhiro Sato Yoshihisa Katsuta Akimasa Shiigi Juri Ueda Chika Oyama Yuko Fujikawa Isabelle Miyazawa Takahiro Ohara Kazuhiro Sumitomo Shigeru Sato Nobuo Koinuma Atsuhiro Kanno Katsutoshi Furukawa Source Type: research

Nephrotoxicity of Immune Checkpoint Inhibitors: A Disproportionality Analysis from 2013 to 2020
This study aimed to systematically characterize nephrotoxicity after ICI initiation. Data were extracted from the US FDA Adverse Event Reporting System (FAERS) database. Disproportionality analysis, including information components (ICs) and reporting odds ratios (RORs), was performed to determine the potential renal toxicity of ICIs. A total of 7,204 reports of renal adverse events (AEs) were identified in the FAERS database. Renal AEs were most commonly reported for nivolumab (46.84%). Strong signals were detected in male patients combined with ICIs. In the clinical application of ICIs, attention should be paid to patien...
Source: The Tohoku Journal of Experimental Medicine - August 26, 2021 Category: Research Authors: Jiaming Qu Yanming Ding Kaiwen Jiang Junxia Hao Yuanzhi Li Aijun Zhang Zhaohang Li Guanpeng Qi Ze Xu Xin Liu Juman Ma Kaishun Bi Zuojing Li Source Type: research

Beh çet's Disease with Extremely High Levels of Urinary β2-Microglobulin after Non-Steroidal Anti-Inflammatory Drug Treatment
Tohoku J Exp Med. 2021;254(4):283-286. doi: 10.1620/tjem.254.283.ABSTRACTBehçet's disease is an inflammatory disease which manifests itself as various symptoms, such as uveitis, oral and genital aphthae, erythema nodosa, gastro-intestinal ulcerations and encephalopathy. Among the manifestations, renal dysfunction is reported in some percentage of the patients with this disorder. We experienced a middle-aged male with Behçet's disease who showed an extremely high level of urinary β2-microglulin, which is one of the markers of renal dysfunction, despite normal serum creatinine levels. The patient was on no...
Source: The Tohoku Journal of Experimental Medicine - August 26, 2021 Category: Research Authors: Ryohei Ogino Karin Shimada Daiki Narai Masanori Goto Katsuhiro Sato Yoshihisa Katsuta Akimasa Shiigi Juri Ueda Chika Oyama Yuko Fujikawa Isabelle Miyazawa Takahiro Ohara Kazuhiro Sumitomo Shigeru Sato Nobuo Koinuma Atsuhiro Kanno Katsutoshi Furukawa Source Type: research

Analysis of Gender Sensitivity of Turkey's Disaster Legislation to Create a Disaster-Resilient Society
This study aimed to evaluate the disaster legislation of Turkey in the context of gender equality. We investigated 17 non-technical disaster legislations to determine in what context and to what level disaster management is gender-sensitive in Turkey. We also carried out a workshop with experts from governmental bodies and nongovernmental organizations (NGOs), and academics to discuss the gender sensitivity of the legislations. We found that only two of the 17 legislations included a gender perspective. One legislation addressed gender equality and equity very well, while one was partially gender-sensitive and the others 5...
Source: The Tohoku Journal of Experimental Medicine - August 23, 2021 Category: Research Authors: Nuket Paksoy Erbaydar Ebru Inal Onal Edip Kaya Source Type: research

Amniotic Fluid L-Type Fatty Acid-Binding Protein in Predicting Fetal Condition
In this study, we aimed to analyze the effectiveness of amniotic fluid L-FABP as a predictor of fetal condition. We classified singleton pregnancies into groups based on fetal growth restriction (FGR) with and without fetal blood flow abnormalities (FGR and healthy-FGR groups, respectively) and the non-FGR group (control group). We collected amniotic fluid at the time of vaginal delivery, cesarean section and amniocentesis, and compared the patient characteristics, clinical outcomes and amniotic fluid levels of L-FABP between the groups. We analyzed 153 singleton pregnancies and 186 amniotic fluid samples (FGR group, 6 (3....
Source: The Tohoku Journal of Experimental Medicine - August 23, 2021 Category: Research Authors: Daisuke Katsura Shunichiro Tsuji Kaori Hayashi Shinsuke Tokoro Rika Zen Takako Hoshiyama Fuminori Kimura Nobuyuki Kita Takashi Murakami Source Type: research

Analysis of Gender Sensitivity of Turkey's Disaster Legislation to Create a Disaster-Resilient Society
This study aimed to evaluate the disaster legislation of Turkey in the context of gender equality. We investigated 17 non-technical disaster legislations to determine in what context and to what level disaster management is gender-sensitive in Turkey. We also carried out a workshop with experts from governmental bodies and nongovernmental organizations (NGOs), and academics to discuss the gender sensitivity of the legislations. We found that only two of the 17 legislations included a gender perspective. One legislation addressed gender equality and equity very well, while one was partially gender-sensitive and the others 5...
Source: The Tohoku Journal of Experimental Medicine - August 23, 2021 Category: Research Authors: Nuket Paksoy Erbaydar Ebru Inal Onal Edip Kaya Source Type: research

Amniotic Fluid L-Type Fatty Acid-Binding Protein in Predicting Fetal Condition
In this study, we aimed to analyze the effectiveness of amniotic fluid L-FABP as a predictor of fetal condition. We classified singleton pregnancies into groups based on fetal growth restriction (FGR) with and without fetal blood flow abnormalities (FGR and healthy-FGR groups, respectively) and the non-FGR group (control group). We collected amniotic fluid at the time of vaginal delivery, cesarean section and amniocentesis, and compared the patient characteristics, clinical outcomes and amniotic fluid levels of L-FABP between the groups. We analyzed 153 singleton pregnancies and 186 amniotic fluid samples (FGR group, 6 (3....
Source: The Tohoku Journal of Experimental Medicine - August 23, 2021 Category: Research Authors: Daisuke Katsura Shunichiro Tsuji Kaori Hayashi Shinsuke Tokoro Rika Zen Takako Hoshiyama Fuminori Kimura Nobuyuki Kita Takashi Murakami Source Type: research

Analysis of Gender Sensitivity of Turkey's Disaster Legislation to Create a Disaster-Resilient Society
This study aimed to evaluate the disaster legislation of Turkey in the context of gender equality. We investigated 17 non-technical disaster legislations to determine in what context and to what level disaster management is gender-sensitive in Turkey. We also carried out a workshop with experts from governmental bodies and nongovernmental organizations (NGOs), and academics to discuss the gender sensitivity of the legislations. We found that only two of the 17 legislations included a gender perspective. One legislation addressed gender equality and equity very well, while one was partially gender-sensitive and the others 5...
Source: The Tohoku Journal of Experimental Medicine - August 23, 2021 Category: Research Authors: Nuket Paksoy Erbaydar Ebru Inal Onal Edip Kaya Source Type: research

Amniotic Fluid L-Type Fatty Acid-Binding Protein in Predicting Fetal Condition
In this study, we aimed to analyze the effectiveness of amniotic fluid L-FABP as a predictor of fetal condition. We classified singleton pregnancies into groups based on fetal growth restriction (FGR) with and without fetal blood flow abnormalities (FGR and healthy-FGR groups, respectively) and the non-FGR group (control group). We collected amniotic fluid at the time of vaginal delivery, cesarean section and amniocentesis, and compared the patient characteristics, clinical outcomes and amniotic fluid levels of L-FABP between the groups. We analyzed 153 singleton pregnancies and 186 amniotic fluid samples (FGR group, 6 (3....
Source: The Tohoku Journal of Experimental Medicine - August 23, 2021 Category: Research Authors: Daisuke Katsura Shunichiro Tsuji Kaori Hayashi Shinsuke Tokoro Rika Zen Takako Hoshiyama Fuminori Kimura Nobuyuki Kita Takashi Murakami Source Type: research

Postinfectious Bronchiolitis Obliterans Misdiagnosed as Bronchial Asthma in a Pediatric Patient
Tohoku J Exp Med. 2021;254(4):257-260. doi: 10.1620/tjem.254.257.ABSTRACTBronchiolitis obliterans is a chronic obstructive respiratory disease involving stenosis or occlusion of the bronchioles and smaller airways. The prognosis of bronchiolitis obliterans is poor, and the patient might require home oxygen therapy and/or lung transplantation. Bronchiolitis obliterans has various etiologies; in children, the most common causes are infections by respiratory pathogens like adenoviruses. In such cases, the condition is termed as postinfectious bronchiolitis obliterans. A 7-year-old girl was diagnosed with bronchial asthma at t...
Source: The Tohoku Journal of Experimental Medicine - August 19, 2021 Category: Research Authors: Yuji Fujita Kenji Miyamoto George Imataka Shigemi Yoshihara Source Type: research

Postinfectious Bronchiolitis Obliterans Misdiagnosed as Bronchial Asthma in a Pediatric Patient
Tohoku J Exp Med. 2021;254(4):257-260. doi: 10.1620/tjem.254.257.ABSTRACTBronchiolitis obliterans is a chronic obstructive respiratory disease involving stenosis or occlusion of the bronchioles and smaller airways. The prognosis of bronchiolitis obliterans is poor, and the patient might require home oxygen therapy and/or lung transplantation. Bronchiolitis obliterans has various etiologies; in children, the most common causes are infections by respiratory pathogens like adenoviruses. In such cases, the condition is termed as postinfectious bronchiolitis obliterans. A 7-year-old girl was diagnosed with bronchial asthma at t...
Source: The Tohoku Journal of Experimental Medicine - August 19, 2021 Category: Research Authors: Yuji Fujita Kenji Miyamoto George Imataka Shigemi Yoshihara Source Type: research