Am J Physiol Endocrinol Metab; +30 new citations
30 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Endocrinol Metab These pubmed results were generated on 2019/11/22PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. (Source: Am J Physiol Endocri...)
Source: Am J Physiol Endocri... - November 22, 2019 Category: Endocrinology Tags: Report Source Type: research

Mitochondrial Dysfunction Plays a Key Role in the Development of Neurodegenerative Diseases in Diabetes.
Abstract Mitochondria have an essential function in cell survival due to their role in bioenergetics, reactive oxygen species generation, calcium buffering, and other metabolic activities. Mitochondrial dysfunctions are commonly found in neurodegenerative diseases (NDs), and diabetes is a risk factor for NDs. However, the role of mitochondria in diabetic neurodegeneration is still unclear. In the current study, we reviewed the latest evidence on the role of mitochondrial dysfunctions in the development of diabetes-related NDs and the underlying molecular mechanisms. Hypoglycemic agents, especially metformin, have ...
Source: Am J Physiol Endocri... - November 12, 2019 Category: Endocrinology Authors: Cheng H, Gang X, Liu Y, Wang G, Zhao X, Wang G Tags: Am J Physiol Endocrinol Metab Source Type: research

Uncoupling protein 1 and the capacity for non-shivering thermogenesis are components of the glucose homeostatic system.
Abstract Uncoupling protein 1 provides non-shivering thermogenesis fueled by the dissipation of energy from macronutrients in brown and brite adipocytes. The availability of thermogenic fuels is facilitated by the uptake of extracellular glucose. This conjunction renders thermogenic adipocytes in brown and white adipose tissue a potential target against obesity and glucose intolerance. We employed wildtype and uncoupling protein 1-ablated mice to elucidate this relationship. In three experiments of similar setup, uncoupling protein 1-ablated mice fed a high‑fat diet had either reduced or similar body mass gain, ...
Source: Am J Physiol Endocri... - November 12, 2019 Category: Endocrinology Authors: Maurer SF, Fromme T, Mocek S, Zimmermann A, Klingenspor M Tags: Am J Physiol Endocrinol Metab Source Type: research

Reply to Letter to the Editor: "No insulating effect of obesity, neither in mice nor in humans".
Reply to Letter to the Editor: "No insulating effect of obesity, neither in mice nor in humans". Am J Physiol Endocrinol Metab. 2019 Nov 01;317(5):E954-E956 Authors: Brychta RJ, Cypess AM, Reitman ML, Chen KY PMID: 31697208 [PubMed - in process] (Source: Am J Physiol Endocri...)
Source: Am J Physiol Endocri... - November 1, 2019 Category: Endocrinology Authors: Brychta RJ, Cypess AM, Reitman ML, Chen KY Tags: Am J Physiol Endocrinol Metab Source Type: research

No insulating effect of obesity, neither in mice nor in humans.
PMID: 31697209 [PubMed - in process] (Source: Am J Physiol Endocri...)
Source: Am J Physiol Endocri... - November 1, 2019 Category: Endocrinology Authors: Fischer AW, Cannon B, Nedergaard J Tags: Am J Physiol Endocrinol Metab Source Type: research

Cardiac overexpression of perilipin 2 induces atrial steatosis, connexin 43 remodeling, and atrial fibrillation in aged mice.
Abstract Atrial fibrillation (AF) is prevalent in patients with obesity and diabetes, and such patients often exhibit cardiac steatosis. Since the role of cardiac steatosis per se in the induction of AF has not been elucidated, the present study was designed to explore the relation between cardiac steatosis and AF. Transgenic (Tg) mice with cardiac-specific overexpression of perilipin 2 (PLIN2) were housed in the laboratory for more than 12 months before the study. Electron microscopy of the atrium of PLIN2-Tg mice showed accumulation of small lipid droplets around mitochondrial chains, and 5- to 9-fold greater at...
Source: Am J Physiol Endocri... - October 29, 2019 Category: Endocrinology Authors: Sato S, Suzuki J, Hirose M, Yamada M, Zenimaru Y, Nakaya T, Ichikawa M, Imagawa M, Takahashi S, Ikuyama S, Konoshita T, Kraemer FB, Ishizuka T Tags: Am J Physiol Endocrinol Metab Source Type: research

Hepatic IKK epsilon expression is dispensable for high-fat feeding-induced increases in liver lipid content and alterations in glucose tolerance.
Abstract There are endocrine and immunological changes that occur during onset and progression of the overweight and obese states. The inhibitor of nuclear factor kappa B kinase subunit epsilon (IKKε) was originally described as an inducible protein kinase; whole-body gene deletion or systemic pharmaceutical targeting of this kinase improved insulin sensitivity and glucose tolerance in mice. To investigate the primary sites of action associated with IKKε during weight gain, we describe the first mouse line with conditional elimination of IKKε in the liver (IKKε alb-/-). IKKε...
Source: Am J Physiol Endocri... - October 29, 2019 Category: Endocrinology Authors: Collier JJ, Batdorf HM, Mendoza TM, Burk DH, Martin TM, Zhang J, Mynatt RL, Burke SJ Tags: Am J Physiol Endocrinol Metab Source Type: research

Transcription profiling in the liver of undernourished male rat offspring reveals altered lipid metabolism pathways and predisposition to hepatic steatosis.
Abstract Clinical and animal studies have reported an association between low birth weight and the development of non-alcoholic fatty liver disease (NAFLD) in offspring. Using a model of prenatal maternal 70% food restriction diet (FR30) in rat, we previously showed that maternal undernutrition predisposes offspring to altered lipid metabolism in adipose tissue, especially under high-fat (HF) diet. Here, using microarray-based expression profiling combined with metabolic, endocrine, biochemical, histological and lipidomic approaches, we assessed whether FR30 procedure sensitizes adult male offspring to impaired li...
Source: Am J Physiol Endocri... - October 22, 2019 Category: Endocrinology Authors: Lecoutre S, Montel V, Vallez E, Pourpe C, Delmont A, Eury E, Verbanck M, Dickes-Coopman A, Daubersies P, Lesage J, Laborie C, Tailleux A, Staels B, Froguel P, Breton C, Vieau D Tags: Am J Physiol Endocrinol Metab Source Type: research

Liver-derived IGF-I is not required for protection against osteoarthritis in male mice.
CONCLUSION: Our study is the first to investigate whether there is an association between circulating IGF-I and OA in mice. We conclude that although an ~80% reduction of circulating IGF-I is associated with reduced amount of cortical bone, OA development is clearly not intensified, and may instead be slightly reduced, in male LI-IGF-I-/- mice. PMID: 31638855 [PubMed - as supplied by publisher] (Source: Am J Physiol Endocri...)
Source: Am J Physiol Endocri... - October 22, 2019 Category: Endocrinology Authors: Törnqvist AE, Sophocleous A, Ralston SH, Ohlsson C, Svensson J Tags: Am J Physiol Endocrinol Metab Source Type: research

ACE2 exerts anti-obesity effect via stimulating brown adipose tissue and induction of browning in white adipose tissue.
In this study, we hypothesized that ACE2 exerts a strong anti-obesity effect by increasing Ang1-7 levels. We injected intraperitoneally recombinant human ACE2 (rhACE2) (2.0mg/ kg/day) for 28 days to high-fat diet (HFD) induced obesity mice. rhACE2 treatment decreased body weight and improved glucose metabolism. Furthermore, rhACE2 increased oxygen consumption and upregulated thermogenesis in HFD-fed mice. In the rhACE2 treatment group, BAT mass increased, accompanied with ameliorated insulin signaling and increased protein levels of UCP-1 and PRDM16. Importantly, subcutaneous white adipose tissue (sWAT) mass decreased, con...
Source: Am J Physiol Endocri... - October 22, 2019 Category: Endocrinology Authors: Kawabe Y, Mori J, Morimoto H, Yamaguchi M, Miyagaki S, Ota T, Tsuma Y, Fukuhara S, Nakajima H, Oudit GY, Hosoi H Tags: Am J Physiol Endocrinol Metab Source Type: research

Influence of Obesity, Weight Loss, and Free Fatty Acids on Skeletal Muscle Clock Gene Expression.
JR Abstract The molecular circadian clock plays a role in metabolic homeostasis. We tested the hypothesis obesity and systemic factors associated with insulin resistance affect skeletal muscle clock gene expression. We determined clock gene expression in skeletal muscle of obese women (n=5) and men (n=18) before and 6 months after Roux-en-Y gastric bypass (RYGB) surgery and normal weight controls (women n=6, men n=8). Skeletal muscle clock gene expression was affected by obesity and weight loss. CRY1 mRNA (P=0.05) was increased and DBP mRNA (P
Source: Am J Physiol Endocri... - October 15, 2019 Category: Endocrinology Authors: Sardon Puig L, Pillon NJ, Näslund E, Krook A, Zierath JR Tags: Am J Physiol Endocrinol Metab Source Type: research

The intrinsically labeled protein approach is the preferred method to quantify the release of dietary protein-derived amino acids into the circulation.
PMID: 31423800 [PubMed - in process] (Source: Am J Physiol Endocri...)
Source: Am J Physiol Endocri... - August 20, 2019 Category: Endocrinology Authors: Trommelen J, Holwerda AM, Nyakayiru J, Gorissen SHM, Rooyackers O, Burd NA, Boirie Y, van Loon LJC Tags: Am J Physiol Endocrinol Metab Source Type: research

Reply to Letter to the Editor: "The intrinsically labeled protein approach is the preferred method to quantify the release of dietary protein-derived amino acids into the circulation".
Reply to Letter to the Editor: "The intrinsically labeled protein approach is the preferred method to quantify the release of dietary protein-derived amino acids into the circulation". Am J Physiol Endocrinol Metab. 2019 Sep 01;317(3):E435 Authors: Wolfe RR, Park S, Kim IY, Starck C, Marquis BJ, Ferrando AA, Moughan PJ PMID: 31423801 [PubMed - in process] (Source: Am J Physiol Endocri...)
Source: Am J Physiol Endocri... - August 20, 2019 Category: Endocrinology Authors: Wolfe RR, Park S, Kim IY, Starck C, Marquis BJ, Ferrando AA, Moughan PJ Tags: Am J Physiol Endocrinol Metab Source Type: research

Serum miR-204 is an early biomarker of type 1 diabetes-associated pancreatic beta-cell loss.
Abstract Pancreatic beta-cell death is a major factor in the pathogenesis of type 1 diabetes (T1D), but straightforward methods to measure beta-cell loss in humans are lacking underlining the need for novel biomarkers. Using studies in INS-1 cells, human islets, diabetic mice and serum samples of subjects with T1D at different stages, we have identified serum miR-204 as an early biomarker of T1D-associated beta-cell loss in humans. MiR-204 is a highly enriched microRNA in human beta-cells and we found that it is released from dying beta-cells and detectable in human serum. We further discovered that serum miR-204 ...
Source: Am J Physiol Endocri... - August 13, 2019 Category: Endocrinology Authors: Xu G, Thielen LA, Chen J, Grayson TB, Grimes T, Bridges SL, Tse HM, Smith B, Patel R, Li P, Evans-Molina C, Ovalle F, Shalev A Tags: Am J Physiol Endocrinol Metab Source Type: research

The TRPV1 channel regulates glucose metabolism.
In conclusion, TRPV1 regulates glucose disposal in HFD-mice. We propose TRPV1 plays a role coordinating glucose metabolism in EDL under conditions of metabolic stress. PMID: 31408376 [PubMed - as supplied by publisher] (Source: Am J Physiol Endocri...)
Source: Am J Physiol Endocri... - August 13, 2019 Category: Endocrinology Authors: Page AJ, Hatzinikolas G, Vincent AD, Cavuoto P, Wittert GA Tags: Am J Physiol Endocrinol Metab Source Type: research

Calcification biomarkers and vascular dysfunction in obesity and type 2 diabetes: influence of oral hypoglycemic agents.
Abstract Vascular aging in obesity and type 2 diabetes (T2D) is associated with progressive vascular calcification, an independent predictor of morbidity and mortality. Pathways for vascular calcification modulate inhibition of bone matrix deposition thus regulating calcium deposits. We investigated the association between biomarkers of vascular calcification and vasodilator function in obesity or T2D, and whether antidiabetic therapies favorably impact those markers. Circulating levels of proteins involved in vascular calcification, such as osteopontin (OPN), osteoprotegerin (OPG), regulated on activation, normal...
Source: Am J Physiol Endocri... - August 13, 2019 Category: Endocrinology Authors: Schinzari F, Tesauro M, Bertoli A, Valentini A, Veneziani A, Cambia U, Cardillo C Tags: Am J Physiol Endocrinol Metab Source Type: research

Potential Influence of the Corpus Luteum on Circulating Reproductive and Volume Regulatory Hormones, Angiogenic and Immunoregulatory Factors in Pregnant Women.
Abstract Cardiovascular function is impaired and preeclampsia risk elevated in women conceiving by in vitro fertilization (IVF) in the absence of a corpus luteum (CL). Here, we report the serial evaluation of hormones and other circulating factors in women who conceived with (or without) IVF. After a pre-pregnancy baseline, the study participants (n=19-24/cohort) were evaluated six times during pregnancy, and once postpartum (~1.6 yr). IVF pregnancies were stratified by protocol and CL number, i.e., ovarian stimulation (>1 CL) or hypothalamic-pituitary suppression (0 CL) vs spontaneous conceptions (1 CL). Resul...
Source: Am J Physiol Endocri... - August 13, 2019 Category: Endocrinology Authors: Conrad KP, Graham GM, Chi YY, Zhai X, Li M, Williams RS, Rhoton-Vlasak A, Segal MS, Wood CE, Keller-Wood M Tags: Am J Physiol Endocrinol Metab Source Type: research

Adipocyte specific deletion of IL-6 does not attenuate obesity-induced weight gain or glucose intolerance in mice.
CONCLUSION: Adipocyte specific IL-6 does not contribute to whole body glucose intolerance in obese mice. PMID: 31386565 [PubMed - as supplied by publisher] (Source: Am J Physiol Endocri...)
Source: Am J Physiol Endocri... - August 6, 2019 Category: Endocrinology Authors: Whitham M, Pal M, Petzold T, Hjorth M, Egan CL, Brunner JS, Estevez E, Iliades P, Zivanovic B, Reibe S, Hughes WE, Findeisen M, Hidalgo J, Febbraio MA Tags: Am J Physiol Endocrinol Metab Source Type: research

A single day of high fat diet feeding induces lipid accumulation and insulin resistance in brown adipose tissue in mice.
In conclusion, we showed that a single day of HFD feeding is sufficient to induce the first signs of whitening and insulin resistance in BAT, which reduces the uptake of glucose and triglyceride-derived fatty acids. BAT whitening and insulin resistance is likely sustained by reduced mitochondrial oxidation due to changes in mitochondrial dynamics and macrophage infiltration, respectively. Likely, the switch to HFD swiftly induces thermogenesis in other metabolic organs, which allows attenuation of BAT thermogenesis. PMID: 31386566 [PubMed - as supplied by publisher] (Source: Am J Physiol Endocri...)
Source: Am J Physiol Endocri... - August 6, 2019 Category: Endocrinology Authors: Kuipers EN, Held NM, In Het Panhuis W, Modder M, Ruppert PMM, Kersten S, Kooijman S, Guigas B, Houtkooper RH, Rensen PCN, Boon MR Tags: Am J Physiol Endocrinol Metab Source Type: research

IGF-1/IGF-1R blockade ameliorates diabetic kidney disease through normalizing Snail1 expression in a mouse model.
This study investigated the role of insulin-like growth factor-1/insulin-like growth factor-1 receptor (IGF-1/IGF-1R) in the genesis and progression of diabetic kidney disease (DKD) in a streptozocin (STZ)-induced mouse diabetes model. We show elevated IGF-1 expression in the DKD kidneys after 16 weeks of diabetic onset. Intraperitoneal administration of IGF-1R inhibitor (GSK4529) from weeks 8 to 16 post-diabetes induction ameliorated urinary albumin excretion and kidney histological changes due to diabetes, including amelioration of glomerulomegaly, inflammatory infiltration, and tubulointerstitial fibrosis. The GSK4529 t...
Source: Am J Physiol Endocri... - July 30, 2019 Category: Endocrinology Authors: Dong R, Yu J, Yu F, Yang S, Qian Q, Zha Y Tags: Am J Physiol Endocrinol Metab Source Type: research

eNOS Deletion Impairs Mitochondrial Quality Control and Exacerbates Western Diet Induced NASH.
Abstract Dysregulated mitochondrial quality control leads to mitochondrial functional impairments that are central to the development and progression of hepatic steatosis to steatohepatitis (NASH). Here we identify hepatocellular localized endothelial nitric oxide synthase (eNOS) as a novel master regulator of mitochondrial quality control. Mice lacking eNOS were more susceptible to western diet induced hepatic inflammation and fibrosis in conjunction with decreased markers of mitochondrial biogenesis and turnover. The hepatocyte specific influence was verified via Magnetic Activated Cell Sorting (MACS) purified p...
Source: Am J Physiol Endocri... - July 30, 2019 Category: Endocrinology Authors: Sheldon RD, Meers GM, Morris EM, Linden MA, Cunningham RP, Ibdah JA, Thyfault JP, Laughlin MH, Rector RS Tags: Am J Physiol Endocrinol Metab Source Type: research

Early nutrition and gut microbiome: interrelationship between bacterial metabolism, immune system, brain structure and neurodevelopment.
E, Campoy C Abstract Disturbances of diet during pregnancy and early postnatal life may impact colonization of gut microbiota during early life, which could influence infant health, leading to potential long-lasting consequences later in life. This is a non-systematic review that explores the recent scientific literature to provide a general perspective of this broad topic. Several studies have shown that gut microbiota composition is related to changes in metabolism, energy balance and immune system disturbances, through interaction between microbiota metabolites and host receptors by the gut-brain axis. Moreover...
Source: Am J Physiol Endocri... - July 30, 2019 Category: Endocrinology Authors: Cerdó T, Diéguez E, Campoy C Tags: Am J Physiol Endocrinol Metab Source Type: research

Disruptions to the Limb Muscle Core Molecular Clock Coincide with Changes in Mitochondrial Quality Control following Androgen Depletion.
Abstract Androgen depletion in humans leads to significant atrophy of the limb muscles. However, the pathways by which androgens regulate limb muscle mass are unclear. Our laboratory previously showed that mitochondrial degradation was related to the induction of autophagy and the degree of muscle atrophy following androgen depletion, implying decreased mitochondrial quality contributes to muscle atrophy. To increase our understanding of androgen-sensitive pathways regulating decreased mitochondrial quality, total RNA from the tibialis anterior of sham and castrated mice was subjected to microarray analysis. Using...
Source: Am J Physiol Endocri... - July 30, 2019 Category: Endocrinology Authors: Rossetti ML, Esser KA, Lee C, Tomko RJ, Eroshkin AM, Gordon BS Tags: Am J Physiol Endocrinol Metab Source Type: research

GPR120 controls neonatal brown adipose tissue thermogenic induction.
t M, Villarroya F Abstract Adaptive induction of thermogenesis in brown adipose tissue (BAT) is essential for the survival of mammals after birth. We herein show that G-coupled receptor protein-120 (GPR120) expression is dramatically induced after birth in mouse BAT. GPR120 expression in neonatal BAT is the highest among GPR120-expressing tissues in mouse at any developmental stage tested. The induction of GPR120 in neonatal BAT is caused by the postnatal thermal stress rather than by the initiation of suckling. GPR120-null neonates were found to be relatively intolerant to cold: close to one-third did not survive...
Source: Am J Physiol Endocri... - July 30, 2019 Category: Endocrinology Authors: Quesada-López T, Gavaldà-Navarro A, Morón-Ros S, Campderros L, Iglesias R, Giralt M, Villarroya F Tags: Am J Physiol Endocrinol Metab Source Type: research

Anomalous bone changes in ovariectomized type-2 diabetic rats: inappropriately low bone turnover with bone loss in an estrogen-deficient condition.
In conclusion, a combined T2DM and estrogen deficiency led to bone loss that did not differ from each factor alone. However, the combination worsened the integrity and suppressed the turnover, which might eventually result in adynamic bone disease. PMID: 31361547 [PubMed - as supplied by publisher] (Source: Am J Physiol Endocri...)
Source: Am J Physiol Endocri... - July 30, 2019 Category: Endocrinology Authors: Aeimlapa R, Wongdee K, Tiyasatkulkovit W, Kengkoom K, Krishnamra N, Charoenphandhu N Tags: Am J Physiol Endocrinol Metab Source Type: research

Sexual dimorphism in hypothalamic inflammation in the offspring of dams exposed to diet rich in high fat and branched chain amino acids.
In this study, we exposed pregnant and lactating C57BL/6JB female mice to either HFD, HFD with supplemented BCAA (HFD+BCAA), or standard chow (SC) diets, and studied offspring metabolic phenotypes. Both maternal HFD and HFD supplemented with BCAA had similar effect rendered the offspring metabolic imbalance and impaired their ability to cope with HFD when challenged during aging. The metabolic effects of HFD challenge were more profound in females, worsening female offspring ability to cope with an HFD challenge by activating hypothalamic inflammation in aging. Moreover, the sex differences in hypothalamic ER-α expre...
Source: Am J Physiol Endocri... - July 30, 2019 Category: Endocrinology Authors: Sadagurski M, Debarba L, Werneck-de-Castro JP, Ali Awada A, Baker TA, Bernal-Mizrachi E Tags: Am J Physiol Endocrinol Metab Source Type: research

Leptin receptor-expressing neurons in the ventromedial nucleus of the hypothalamus contribute to weight loss caused by fourth ventricle leptin infusions.
Abstract Leptin administration into the hindbrain, and specifically the nucleus of the solitary tract, increases phosphorylated signal transducer and activator of transcription 3 (pSTAT3), a marker of leptin receptor activation, in hypothalamic nuclei known to express leptin receptors. The ventromedial nucleus of the hypothalamus (VMH) shows the greatest response with a three-fold increase in pSTAT3. This experiment tested the importance of VMH leptin responsiveness in mediating weight loss caused by fourth ventricle (4V) leptin infusion. Male Sprague Dawley rats received bilateral VMH 75 nl injections of 260 ng/m...
Source: Am J Physiol Endocri... - July 30, 2019 Category: Endocrinology Authors: Seamon M, Ahn W, Li AJ, Ritter S, Harris RBS Tags: Am J Physiol Endocrinol Metab Source Type: research

Am J Physiol Endocrinol Metab; +31 new citations
31 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Endocrinol Metab These pubmed results were generated on 2019/07/28PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. (Source: Am J Physiol Endocri...)
Source: Am J Physiol Endocri... - July 28, 2019 Category: Endocrinology Tags: Report Source Type: research

Am J Physiol Endocrinol Metab; +22 new citations
22 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Endocrinol Metab These pubmed results were generated on 2019/07/11PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. (Source: Am J Physiol Endocri...)
Source: Am J Physiol Endocri... - July 11, 2019 Category: Endocrinology Tags: Report Source Type: research

Am J Physiol Endocrinol Metab; +22 new citations
22 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Endocrinol Metab These pubmed results were generated on 2019/07/07PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. (Source: Am J Physiol Endocri...)
Source: Am J Physiol Endocri... - July 7, 2019 Category: Endocrinology Tags: Report Source Type: research

Heat therapy improves glucose tolerance and adipose tissue insulin signaling in obese women with polycystic ovary syndrome.
Abstract Polycystic Ovary Syndrome (PCOS) is associated with high rates of obesity and metabolic dysfunction. Repeated passive heat exposure (termed 'heat therapy') is a novel lifestyle intervention for improving health in obese women with PCOS. The purpose of this study was to examine changes in metabolic function in obese women with PCOS following heat therapy. Eighteen age- and BMI-matched obese women with PCOS (Age: 27±1y, BMI 41.3±1.1 kg·m2) were assigned to heat therapy (HT) or time control (CON). HT subjects underwent 30 one-hour hot tub sessions over 8-10 weeks, while CON subjects comp...
Source: Am J Physiol Endocri... - May 28, 2019 Category: Endocrinology Authors: Ely BR, Clayton ZS, McCurdy CE, Pfeiffer J, Needham KW, Comrada LN, Minson CT Tags: Am J Physiol Endocrinol Metab Source Type: research

mTORC1/rpS6 signaling complex that modifies BTB transport function - an in vivo study using the adjudin model.
Abstract Studies have shown that the mTORC1/rpS6 signaling cascade regulates Sertoli cell blood-testis barrier (BTB) dynamics. For instance, specific inhibition of mTORC1 by treating Sertoli cells with rapamycin promotes the Sertoli cell barrier, making it "tighter". However, activation of mTORC1 by overexpressing a full-length rpS6 cDNA clone (i.e., rpS6-WT, wild type) in Sertoli cells promotes BTB remodeling, making the barrier "leaky". Also, there is an increase in rpS6 and p-rpS6 (phosphorylated and activated rpS6) expression at the BTB in testes at stage VIII-IX of the epithelial cycle, an...
Source: Am J Physiol Endocri... - May 21, 2019 Category: Endocrinology Authors: Yan M, Li L, Mao B, Li H, Li SYT, Mruk D, Silvestrini B, Lian Q, Ge R, Cheng CY Tags: Am J Physiol Endocrinol Metab Source Type: research

The effects of combined glucocorticoid/mineralocorticoid receptor modulation (CORT118335) on energy balance, adiposity, and lipid metabolism in male rats.
Abstract Psychological stress and excess glucocorticoids are associated with metabolic and cardiovascular diseases. Glucocorticoids primarily act through mineralocorticoid (MR) and glucocorticoid receptors (GR), and compounds modulating these receptors show promise in mitigating metabolic and cardiovascular-related phenotypes. CORT118335 (GR/MR modulator) prevents high fat diet-induced weight gain and adiposity in mice, but the ability of this compound to reverse obesity-related symptoms is unknown. Adult male rats were subcutaneously administered CORT118335 (3mg/kg, 10mg/kg, or 30mg/kg) or vehicle once daily. A f...
Source: Am J Physiol Endocri... - May 21, 2019 Category: Endocrinology Authors: Nguyen ET, Berman S, Streicher J, Estrada CM, Caldwell JL, Ghisays V, Ulrich-Lai Y, Solomon MB Tags: Am J Physiol Endocrinol Metab Source Type: research

Leucine co-ingestion augments the muscle protein synthetic response to the ingestion of 15 g protein following resistance exercise in older men.
Abstract BACKGROUND: Older adults have shown an attenuated post-exercise increase in muscle protein synthesis rates following ingestion of smaller amounts of protein when compared to younger adults. Consequently, it has been suggested that older adults require the ingestion of more protein to increase post-exercise muscle protein synthesis rates when compared to younger adults. OBJECTIVE: Weinvestigatedwhether co-ingestion of 1.5 g free leucine with a single, 15 g bolus of protein further augments the post-prandial muscle protein synthetic response during recovery from resistance-type exercise in older men. ...
Source: Am J Physiol Endocri... - May 21, 2019 Category: Endocrinology Authors: Holwerda AM, Paulussen KJM, Overkamp M, Goessens JPB, Kramer IF, Wodzig WKWH, Verdijk LB, de Groot LCPGM, van Loon LJC Tags: Am J Physiol Endocrinol Metab Source Type: research

Effect of portal glucose sensing on incretin hormone secretion in a canine model.
Abstract It is unknown whether activation of hepato-portal vein (PV) glucose sensors plays a role in incretin hormone amplification of oral glucose stimulated insulin secretion (GSIS). In previous studies PV glucose infusion increased GSIS through unknown mechanisms, perhaps neural stimulation of pancreatic beta cells and/or stimulation of gut incretin hormone release. Thus, there could be a difference in the incretin effect when comparing GSIS with portal rather than leg vein (LV) glucose infusion. Plasma insulin and incretin hormones were studied in six overnight-fasted dogs. An oral glucose tolerance test (OGTT...
Source: Am J Physiol Endocri... - May 21, 2019 Category: Endocrinology Authors: Edgerton DS, Kraft G, Smith MS, Moore LM, Farmer B, Scott M, Moore MC, Nauck MA, Cherrington AD Tags: Am J Physiol Endocrinol Metab Source Type: research

Phosphorylation status of fetuin-A is critical for inhibition of insulin action and is correlated with obesity and insulin resistance.
Abstract Fetuin-A, a hepatokine associated with insulin resistance, obesity and incident type 2 diabetes, is shown to exist in both phosphorylated and dephosphorylated forms in circulation. However, studies on fetuin-A phosphorylation status in insulin resistant conditions and its functional significance, are limited. We demonstrate that serum phosphofetuin-A (Ser312) levels were significantly elevated in high-fat diet-induced obese mice, insulin resistant Zucker diabetic fatty rats, and in obese, insulin resistant individuals. Unlike serum total fetuin-A, serum phosphofetuin-A was associated with body weight, ins...
Source: Am J Physiol Endocri... - May 14, 2019 Category: Endocrinology Authors: Ren G, Kim T, Papizan JB, Okerberg CK, Kothari VM, Zaid H, Bilan PJ, Araya-Ramirez F, Littlefield LA, Bowers RL, Mahurin AJ, Nickles MM, Ludvigsen R, He X, Grandjean PW, Mathews ST Tags: Am J Physiol Endocrinol Metab Source Type: research

The neuropeptide 26RFa (QRFP) is a key regulator of glucose homeostasis and its activity is markedly altered in obese/hyperglycemic mice.
In this study, we further characterized the role of the 26RFa/GPR103 peptidergic system in the global regulation of glucose homeostasis using a 26RFa receptor antagonist, and also assessed whether a dysfunction of the 26RFa/GPR103 system occurs in obese hyperglycemic mice. Firstly, we demonstrate that administration of the GPR103 antagonist reduces the global glucose-induced incretin effect and insulin sensitivity whereas, conversely, administration of exogenous 26RFa attenuates glucose-induced hyperglycemia. Using a mouse model of high-fat diet-induced obesity and hyperglycemia, we found a loss of the anti-hyperglcemic ef...
Source: Am J Physiol Endocri... - May 14, 2019 Category: Endocrinology Authors: Prévost G, Arabo A, Le Solliec MA, Bons J, Picot M, Maucotel J, Berrahmoune H, El Mehdi M, Chérifi S, Benani A, Nédélec E, Coëffier M, Leprince J, Nordqvist A, Brunel V, Déchelotte P, Lefebvre H, Anouar Y, Chartrel N Tags: Am J Physiol Endocrinol Metab Source Type: research

Impaired insulin signaling in the B10.D2-Hc0 H2d H2-T18c/oSnJ mouse model of complement factor 5 (C5) deficiency.
Abstract Given the chemoattractant potential of complement factor 5 (C5) and its increased expression in adipose tissue (AT) of obese mice, we determined whether this protein of the innate immune system impacts insulin action. C5 control (C5cont) and spontaneously C5 deficient (C5def, B10.D2-Hc0 H2d H2-T18c/oSnJ) mice were placed on low and high fat diets to investigate their inflammatory and metabolic phenotypes. Adenoviral delivery was used to evaluate the effects of exogenous C5 on systemic metabolism. C5def mice gained less weight than controls while fed a high fat diet; accompanied by reduced AT inflammation,...
Source: Am J Physiol Endocri... - May 14, 2019 Category: Endocrinology Authors: Peterson KR, Gutierrez DA, Kikuchi T, Anderson-Baucum EK, Winn NC, Shuey MM, Bolus WR, McGuinness OP, Hasty AH Tags: Am J Physiol Endocrinol Metab Source Type: research

Advancing Metabolism Research to Overcome Low Litter Survival in Metabolically Stressed Mice.
Abstract Elucidating the mechanism underlying the transmission of metabolic disease to subsequent generations requires robust pre-clinical mouse breeding strategies. Western diets rich in fat and carbohydrates are contributing factors in the rise of diabetes and obesity rates worldwide. Therefore, determining the impact of Western diets consumed by parents on offspring and future generations is critical for understanding the perpetuation of these diseases. Specifically, epigenetic regulation and transgenerational inheritance of metabolic disease is an emerging field of study requiring robust murine models. However...
Source: Am J Physiol Endocri... - May 14, 2019 Category: Endocrinology Authors: Powell CA, Choudhury M Tags: Am J Physiol Endocrinol Metab Source Type: research

Am J Physiol Endocrinol Metab; +50 new citations
50 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Endocrinol Metab These pubmed results were generated on 2019/03/22PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. (Source: Am J Physiol Endocri...)
Source: Am J Physiol Endocri... - March 22, 2019 Category: Endocrinology Tags: Report Source Type: research

Multi-Tissue Analysis of Exercise or Metformin on Doxorubicin-Induced Iron Dysregulation.
Abstract Doxorubicin (DOX) is an effective chemotherapeutic treatment with lasting side effects in heart and skeletal muscle. DOX is known to bind with iron, contributing to oxidative damage resulting in cardiac and skeletal muscle toxicity. However, major cellular changes to iron regulation in response to DOX are poorly understood in liver, heart and skeletal muscle. Additionally, two co-treatments, exercise (EX) or metformin (MET) were studied for their effectiveness in reducing DOX toxicity through ameliorating iron dysregulation and preventing oxidative stress. The purposes of this study were to (1) characteri...
Source: Am J Physiol Endocri... - March 19, 2019 Category: Endocrinology Authors: Mackay AD, Marchant ED, Munk DJ, Watt RK, Hansen JM, Thomson DM, Hancock CR Tags: Am J Physiol Endocrinol Metab Source Type: research

AMPK and PPAR β positive feedback loop regulates endurance exercise-mediated GLUT4 expression in skeletal muscle.
In conclusion, cooperation between AMPK and PPARβ via NRF-1/MEF2A pathway enhances the exercise training mediated adaptive increase in GLUT4 expression and subsequent glucose uptake in skeletal muscle. PMID: 30888859 [PubMed - as supplied by publisher] (Source: Am J Physiol Endocri...)
Source: Am J Physiol Endocri... - March 19, 2019 Category: Endocrinology Authors: Koh J, Hancock CR, Han DH, Holloszy JO, Nair KS, Dasari S Tags: Am J Physiol Endocrinol Metab Source Type: research

Germline or inducible knockout of p300 or CBP in skeletal muscle does not alter insulin sensitivity.
CONCLUSIONS: Muscle-specific loss of either p300 or CBP, be it germline or in adulthood, does not impact energy expenditure, glucose tolerance or skeletal muscle insulin action. PMID: 30888860 [PubMed - as supplied by publisher] (Source: Am J Physiol Endocri...)
Source: Am J Physiol Endocri... - March 19, 2019 Category: Endocrinology Authors: Martins VF, Dent JR, Svensson K, Tahvilian S, Begur M, Lakkaraju S, Buckner EH, LaBarge SA, Hetrick B, McCurdy CE, Schenk S Tags: Am J Physiol Endocrinol Metab Source Type: research

Recurrent Glucose Deprivation Leads to the Preferential Use of Lactate by Neurons in the Ventromedial Hypothalamus.
Abstract Increased GABAergic output in the ventromedial hypothalamus (VMH) contributes to counterregulatory failure in recurrently hypoglycemic (RH) rats and lactate, an alternate fuel source in the brain, contributes to this phenomenon. The current study assessed whether recurring bouts of glucose deprivation enhanced neuronal lactate uptake and if so, whether this influenced GABA output and the counterregulatory responses. Glucose deprivation was induced using 5-thioglucose (5TG). Control rats received an infusion of artificial extracellular fluid. These groups were compared to RH animals. On day 4, the rats und...
Source: Am J Physiol Endocri... - March 19, 2019 Category: Endocrinology Authors: Shah M, Addison A, Wang P, Zhu W, Chan O Tags: Am J Physiol Endocrinol Metab Source Type: research

Myostatin regulates pituitary development and hepatic igf1.
MYOSTATIN REGULATES PITUITARY DEVELOPMENT AND HEPATIC IGF1. Am J Physiol Endocrinol Metab. 2019 Mar 19;: Authors: Czaja W, Nakamura YK, Li N, Eldridge JA, DeAvila DM, Thompson TB, Rodgers BD Abstract Circulating myostatin-attenuating agents are being developed to treat muscle wasting disease despite their potential to produce serious off-target effects as myostatin/activin receptors are widely distributed among many non-muscle tissues. Our studies suggest that the myokine not only inhibits striated muscle growth, but also regulates pituitary development and growth hormone (GH) action in the liver. Usi...
Source: Am J Physiol Endocri... - March 19, 2019 Category: Endocrinology Authors: Czaja W, Nakamura YK, Li N, Eldridge JA, DeAvila DM, Thompson TB, Rodgers BD Tags: Am J Physiol Endocrinol Metab Source Type: research

Anti-atherogenic effects of liraglutide in hyperglycemic apolipoprotein E-null mice via AMP-activated protein kinase independent mechanisms.
In conclusion, liraglutide exerted AMPK-independent anti-atherogenic effects in hyperlipidemic mice with STZ-induced hyperglycemia, with the possible involvement of AMPK-independent suppression of pro-atherogenic molecules in vascular endothelial cells. PMID: 30860874 [PubMed - as supplied by publisher] (Source: Am J Physiol Endocri...)
Source: Am J Physiol Endocri... - March 12, 2019 Category: Endocrinology Authors: Koshibu M, Mori Y, Saito T, Kushima H, Hiromura M, Terasaki M, Takada M, Fukui T, Hirano T Tags: Am J Physiol Endocrinol Metab Source Type: research

Muscle and serum metabolomes are dysregulated in colon-26 tumor-bearing mice despite amelioration of cachexia with activin receptor type 2B ligand blockade.
In conclusion, experimental cancer affected muscle and blood metabolomes mostly independent of blocking ACVR2B ligands. Of the affected metabolites, we have identified free phenylalanine as a promising biomarker of muscle atrophy or cachexia. Finally, the decreased capacity for pyrimidine nucleotide and protein synthesis in tumor-bearing mice opens up new avenues in cachexia research. PMID: 30860875 [PubMed - as supplied by publisher] (Source: Am J Physiol Endocri...)
Source: Am J Physiol Endocri... - March 12, 2019 Category: Endocrinology Authors: Lautaoja JH, Lalowski M, Nissinen TA, Hentilä JJ, Shi Y, Ritvos O, Cheng S, Hulmi JJ Tags: Am J Physiol Endocrinol Metab Source Type: research

Hyperandrogenism and insulin resistance induce gravid uterine defects in association with mitochondrial dysfunction and aberrant ROS production.
illig H Abstract Women with polycystic ovary syndrome (PCOS) are at increased risk of miscarriage, which often accompanies the hyperandrogenism and insulin resistance seen in these patients. However, neither the combinatorial interaction between these two PCOS-related etiological factors nor the mechanisms of their actions in the uterus during pregnancy are well understood. We hypothesised that hyperandrogensim and insulin resistance exert a causative role in miscarriage by inducing defects in uterine function that are accompanied by mitochondrial-mediated oxidative stress, inflammation and perturbed gene expressi...
Source: Am J Physiol Endocri... - March 12, 2019 Category: Endocrinology Authors: Hu M, Zhang Y, Guo X, Jia W, Liu G, Zhang J, Li J, Cui P, Sferruzzi-Perri AN, Han Y, Wu X, Ma H, Brännström M, Shao LR, Billig H Tags: Am J Physiol Endocrinol Metab Source Type: research

Human Paneth cell α-defensin 5 treatment reverses dyslipidemia and improves glucoregulatory capacity in diet-induced obese mice.
CONCLUSION: This study provides proof-of-concept for the use of human defensins to improve host metabolism by mitigating the triad cluster of dyslipidemia, IR and NAFLD. PMID: 30860877 [PubMed - as supplied by publisher] (Source: Am J Physiol Endocri...)
Source: Am J Physiol Endocri... - March 12, 2019 Category: Endocrinology Authors: Larsen IS, Fritzen AM, Carl CS, Agerholm M, Damgaard MTF, Holm JB, Marette A, Nordkild P, Kiens B, Kristiansen K, Wehkamp J, Jensen BAH Tags: Am J Physiol Endocrinol Metab Source Type: research

Exercise Training Promotes a GDF15 Associated Reduction in Fat Mass in Older Adults with Obesity.
Abstract Obesity is a major risk factor for metabolic disease. Growth differentiation factor 15 (GDF15) has shown promise as a weight loss agent for obesity in animal studies. In healthy lean humans, fasting plasma GDF15 increases after acute exercise. However, the role of GDF15 in human obesity, and the response of plasma GDF15 to exercise training in obese patients is unknown. Here, twenty-four sedentary, obese volunteers (age: 65 ± 1 yr; BMI: 35.3 ± 0.9 kg/m2) participated in a supervised 12-wk aerobic exercise intervention: 1hr/day, 5 days/wk at ~85% HRmax with controlled isocaloric diet. As a re...
Source: Am J Physiol Endocri... - March 12, 2019 Category: Endocrinology Authors: Zhang H, Fealy CE, Kirwan JP Tags: Am J Physiol Endocrinol Metab Source Type: research