An alternative hypothesis -- Response to Sheffield et al
Am J Physiol Endocrinol Metab. 2021 Apr 12. doi: 10.1152/ajpendo.00120.2021. Online ahead of print.ABSTRACTnot applicable.PMID:33843277 | DOI:10.1152/ajpendo.00120.2021 (Source: Am J Physiol Endocri...)
Source: Am J Physiol Endocri... - April 12, 2021 Category: Endocrinology Authors: Kitt Falk Petersen Douglas Rothman Gerald I Shulman Source Type: research

Proteome analysis of human adipocytes identifies depot-specific heterogeneity at metabolic control points
Am J Physiol Endocrinol Metab. 2021 Apr 12. doi: 10.1152/ajpendo.00473.2020. Online ahead of print.ABSTRACTAdipose tissue is a primary regulator of energy balance and metabolism. The distribution of adipose tissue depots is of clinical interest because the accumulation of upper-body subcutaneous (ASAT) and visceral adipose tissue (VAT) is associated with cardiometabolic diseases, whereas lower-body gluteal-femoral adipose tissue (GFAT) appears to be protective. There is heterogeneity in morphology and metabolism of adipocytes obtained from different regions of the body, but detailed knowledge of the constituent proteins in...
Source: Am J Physiol Endocri... - April 12, 2021 Category: Endocrinology Authors: Arthe Raajendiran Christoph Krisp David P De Souza Geraldine Ooi Paul R Burton Renea A Taylor Mark P Molloy Matthew J Watt Source Type: research

An alternative hypothesis for why exposure to static magnetic and electric fields treats type 2 diabetes
Am J Physiol Endocrinol Metab. 2021 Apr 12. doi: 10.1152/ajpendo.00657.2020. Online ahead of print.ABSTRACTCarter et al. report that exposure to static magnetic and electric fields (sBE), for as little as 3 days, reverses glucose intolerance and insulin resistance in diet-induced and genetic mouse models of type 2 diabetes (1). They hypothesize that sBE triggers a systemic redox response to modulate insulin sensitivity and that sBE could therefore be used as a noninvasive treatment for type 2 diabetes. However, these authors were unable to define a mechanism to explain how SBE might alter ROS or to identify the specific pr...
Source: Am J Physiol Endocri... - April 12, 2021 Category: Endocrinology Authors: Kitt Falk Petersen Douglas Rothman Gerald I Shulman Source Type: research

Combined effects of a ketogenic diet and exercise training alter mitochondrial and peroxisomal substrate oxidative capacity in skeletal muscle
Am J Physiol Endocrinol Metab. 2021 Apr 12. doi: 10.1152/ajpendo.00410.2020. Online ahead of print.ABSTRACTKetogenic diets (KD) are reported to improve body weight, fat mass, and exercise performance in humans. Unfortunately, most rodent studies have used a low-protein KD, which does not recapitulate diets used by humans. Since skeletal muscle plays a critical role in responding to macronutrient perturbations induced by diet and exercise, the purpose of this study was to test if a normal-protein KD (NPKD) impacts shifts in skeletal muscle substrate oxidative capacity in response to exercise training (ExTr). A high fat, car...
Source: Am J Physiol Endocri... - April 12, 2021 Category: Endocrinology Authors: Tai-Yu Huang Melissa A Linden Scott E Fuller Felicia R Goldsmith Jacob Simon Heidi M Batdorf Matthew C Scott Nabil M Essajee John M Brown Robert C Noland Source Type: research

Evaluation of glucagon-like peptide-1 receptor expression in non-diabetic and diabetic atherosclerotic mice using PET tracer < sup > 68 < /sup > Ga-NODAGA-exendin-4
Am J Physiol Endocrinol Metab. 2021 Apr 12. doi: 10.1152/ajpendo.00465.2020. Online ahead of print.ABSTRACTActivation of glucagon-like peptide-1 receptor (GLP-1R) signaling attenuates development of atherosclerosis and vascular inflammation. However, the expression of GLP-1R in atherosclerotic arteries remains uncertain. We evaluated whether a positron emission tomography (PET) tracer 68Ga-NODAGA-exendin-4 enables detection and imaging of GLP-1R expression in the mouse atherosclerotic aorta. Hypercholesterolemic (LDLR-/-ApoB100/100), hypercholesterolemic and diabetic (IGF-II/LDLR-/-ApoB100/100) as well as healthy control (...
Source: Am J Physiol Endocri... - April 12, 2021 Category: Endocrinology Authors: Mia St åhle Sanna Hellberg Jenni Virta Heidi Liljenb äck Olli Mets älä Xiang-Guo Li Matti Jauhiainen Pekka Saukko Seppo Yl ä-Herttuala Pirjo Nuutila Juhani Knuuti Antti Saraste Anne Roivainen Source Type: research

Counterpoint regarding an alternative hypothesis for why exposure to static magnetic and electric fields treat type 2 diabetes
Am J Physiol Endocrinol Metab. 2021 Apr 12. doi: 10.1152/ajpendo.00110.2021. Online ahead of print.ABSTRACTNot applicable.PMID:33843282 | DOI:10.1152/ajpendo.00110.2021 (Source: Am J Physiol Endocri...)
Source: Am J Physiol Endocri... - April 12, 2021 Category: Endocrinology Authors: Calvin S Carter Sunny Huang Charles Searby Benjamin Cassaidy Michael Miller Wojciech Grzesik Ted B Piorczynski Thomas K Pak Susan Walsh Michael Acevedo Qihong Zhang Kranti Mapuskar Ginger Milne Antentor Othrell Hinton Deng-Fu Guo Robert M Weiss Kyle Bradb Source Type: research

Response to: An alternative hypothesis for why exposure to static magnetic and electric fields treats type 2 diabetes
Am J Physiol Endocrinol Metab. 2021 Apr 12. doi: 10.1152/ajpendo.00119.2021. Online ahead of print.ABSTRACTn/a.PMID:33843283 | DOI:10.1152/ajpendo.00119.2021 (Source: Am J Physiol Endocri...)
Source: Am J Physiol Endocri... - April 12, 2021 Category: Endocrinology Authors: Calvin S Carter Sunny Huang Charles Searby Benjamin Cassaidy Michael Miller Wojciech Grzesik Ted B Piorczynski Thomas K Pak Susan Walsh Michael Acevedo Qihong Zhang Kranti Mapuskar Ginger Milne Antentor Othrell Hinton Deng-Fu Guo Robert M Weiss Kyle Bradb Source Type: research

An alternative hypothesis -- Response to Sheffield et al
Am J Physiol Endocrinol Metab. 2021 Apr 12. doi: 10.1152/ajpendo.00120.2021. Online ahead of print.ABSTRACTnot applicable.PMID:33843277 | DOI:10.1152/ajpendo.00120.2021 (Source: Am J Physiol Endocri...)
Source: Am J Physiol Endocri... - April 12, 2021 Category: Endocrinology Authors: Kitt Falk Petersen Douglas Rothman Gerald I Shulman Source Type: research

Proteome analysis of human adipocytes identifies depot-specific heterogeneity at metabolic control points
Am J Physiol Endocrinol Metab. 2021 Apr 12. doi: 10.1152/ajpendo.00473.2020. Online ahead of print.ABSTRACTAdipose tissue is a primary regulator of energy balance and metabolism. The distribution of adipose tissue depots is of clinical interest because the accumulation of upper-body subcutaneous (ASAT) and visceral adipose tissue (VAT) is associated with cardiometabolic diseases, whereas lower-body gluteal-femoral adipose tissue (GFAT) appears to be protective. There is heterogeneity in morphology and metabolism of adipocytes obtained from different regions of the body, but detailed knowledge of the constituent proteins in...
Source: Am J Physiol Endocri... - April 12, 2021 Category: Endocrinology Authors: Arthe Raajendiran Christoph Krisp David P De Souza Geraldine Ooi Paul R Burton Renea A Taylor Mark P Molloy Matthew J Watt Source Type: research

An alternative hypothesis for why exposure to static magnetic and electric fields treats type 2 diabetes
Am J Physiol Endocrinol Metab. 2021 Apr 12. doi: 10.1152/ajpendo.00657.2020. Online ahead of print.ABSTRACTCarter et al. report that exposure to static magnetic and electric fields (sBE), for as little as 3 days, reverses glucose intolerance and insulin resistance in diet-induced and genetic mouse models of type 2 diabetes (1). They hypothesize that sBE triggers a systemic redox response to modulate insulin sensitivity and that sBE could therefore be used as a noninvasive treatment for type 2 diabetes. However, these authors were unable to define a mechanism to explain how SBE might alter ROS or to identify the specific pr...
Source: Am J Physiol Endocri... - April 12, 2021 Category: Endocrinology Authors: Kitt Falk Petersen Douglas Rothman Gerald I Shulman Source Type: research

Combined effects of a ketogenic diet and exercise training alter mitochondrial and peroxisomal substrate oxidative capacity in skeletal muscle
Am J Physiol Endocrinol Metab. 2021 Apr 12. doi: 10.1152/ajpendo.00410.2020. Online ahead of print.ABSTRACTKetogenic diets (KD) are reported to improve body weight, fat mass, and exercise performance in humans. Unfortunately, most rodent studies have used a low-protein KD, which does not recapitulate diets used by humans. Since skeletal muscle plays a critical role in responding to macronutrient perturbations induced by diet and exercise, the purpose of this study was to test if a normal-protein KD (NPKD) impacts shifts in skeletal muscle substrate oxidative capacity in response to exercise training (ExTr). A high fat, car...
Source: Am J Physiol Endocri... - April 12, 2021 Category: Endocrinology Authors: Tai-Yu Huang Melissa A Linden Scott E Fuller Felicia R Goldsmith Jacob Simon Heidi M Batdorf Matthew C Scott Nabil M Essajee John M Brown Robert C Noland Source Type: research

Evaluation of glucagon-like peptide-1 receptor expression in non-diabetic and diabetic atherosclerotic mice using PET tracer < sup > 68 < /sup > Ga-NODAGA-exendin-4
Am J Physiol Endocrinol Metab. 2021 Apr 12. doi: 10.1152/ajpendo.00465.2020. Online ahead of print.ABSTRACTActivation of glucagon-like peptide-1 receptor (GLP-1R) signaling attenuates development of atherosclerosis and vascular inflammation. However, the expression of GLP-1R in atherosclerotic arteries remains uncertain. We evaluated whether a positron emission tomography (PET) tracer 68Ga-NODAGA-exendin-4 enables detection and imaging of GLP-1R expression in the mouse atherosclerotic aorta. Hypercholesterolemic (LDLR-/-ApoB100/100), hypercholesterolemic and diabetic (IGF-II/LDLR-/-ApoB100/100) as well as healthy control (...
Source: Am J Physiol Endocri... - April 12, 2021 Category: Endocrinology Authors: Mia St åhle Sanna Hellberg Jenni Virta Heidi Liljenb äck Olli Mets älä Xiang-Guo Li Matti Jauhiainen Pekka Saukko Seppo Yl ä-Herttuala Pirjo Nuutila Juhani Knuuti Antti Saraste Anne Roivainen Source Type: research

Counterpoint regarding an alternative hypothesis for why exposure to static magnetic and electric fields treat type 2 diabetes
Am J Physiol Endocrinol Metab. 2021 Apr 12. doi: 10.1152/ajpendo.00110.2021. Online ahead of print.ABSTRACTNot applicable.PMID:33843282 | DOI:10.1152/ajpendo.00110.2021 (Source: Am J Physiol Endocri...)
Source: Am J Physiol Endocri... - April 12, 2021 Category: Endocrinology Authors: Calvin S Carter Sunny Huang Charles Searby Benjamin Cassaidy Michael Miller Wojciech Grzesik Ted B Piorczynski Thomas K Pak Susan Walsh Michael Acevedo Qihong Zhang Kranti Mapuskar Ginger Milne Antentor Othrell Hinton Deng-Fu Guo Robert M Weiss Kyle Bradb Source Type: research

Response to: An alternative hypothesis for why exposure to static magnetic and electric fields treats type 2 diabetes
Am J Physiol Endocrinol Metab. 2021 Apr 12. doi: 10.1152/ajpendo.00119.2021. Online ahead of print.ABSTRACTn/a.PMID:33843283 | DOI:10.1152/ajpendo.00119.2021 (Source: Am J Physiol Endocri...)
Source: Am J Physiol Endocri... - April 12, 2021 Category: Endocrinology Authors: Calvin S Carter Sunny Huang Charles Searby Benjamin Cassaidy Michael Miller Wojciech Grzesik Ted B Piorczynski Thomas K Pak Susan Walsh Michael Acevedo Qihong Zhang Kranti Mapuskar Ginger Milne Antentor Othrell Hinton Deng-Fu Guo Robert M Weiss Kyle Bradb Source Type: research

An alternative hypothesis -- Response to Sheffield et al
Am J Physiol Endocrinol Metab. 2021 Apr 12. doi: 10.1152/ajpendo.00120.2021. Online ahead of print.ABSTRACTnot applicable.PMID:33843277 | DOI:10.1152/ajpendo.00120.2021 (Source: Am J Physiol Endocri...)
Source: Am J Physiol Endocri... - April 12, 2021 Category: Endocrinology Authors: Kitt Falk Petersen Douglas Rothman Gerald I Shulman Source Type: research

Proteome analysis of human adipocytes identifies depot-specific heterogeneity at metabolic control points
Am J Physiol Endocrinol Metab. 2021 Apr 12. doi: 10.1152/ajpendo.00473.2020. Online ahead of print.ABSTRACTAdipose tissue is a primary regulator of energy balance and metabolism. The distribution of adipose tissue depots is of clinical interest because the accumulation of upper-body subcutaneous (ASAT) and visceral adipose tissue (VAT) is associated with cardiometabolic diseases, whereas lower-body gluteal-femoral adipose tissue (GFAT) appears to be protective. There is heterogeneity in morphology and metabolism of adipocytes obtained from different regions of the body, but detailed knowledge of the constituent proteins in...
Source: Am J Physiol Endocri... - April 12, 2021 Category: Endocrinology Authors: Arthe Raajendiran Christoph Krisp David P De Souza Geraldine Ooi Paul R Burton Renea A Taylor Mark P Molloy Matthew J Watt Source Type: research

An alternative hypothesis for why exposure to static magnetic and electric fields treats type 2 diabetes
Am J Physiol Endocrinol Metab. 2021 Apr 12. doi: 10.1152/ajpendo.00657.2020. Online ahead of print.ABSTRACTCarter et al. report that exposure to static magnetic and electric fields (sBE), for as little as 3 days, reverses glucose intolerance and insulin resistance in diet-induced and genetic mouse models of type 2 diabetes (1). They hypothesize that sBE triggers a systemic redox response to modulate insulin sensitivity and that sBE could therefore be used as a noninvasive treatment for type 2 diabetes. However, these authors were unable to define a mechanism to explain how SBE might alter ROS or to identify the specific pr...
Source: Am J Physiol Endocri... - April 12, 2021 Category: Endocrinology Authors: Kitt Falk Petersen Douglas Rothman Gerald I Shulman Source Type: research

Combined effects of a ketogenic diet and exercise training alter mitochondrial and peroxisomal substrate oxidative capacity in skeletal muscle
Am J Physiol Endocrinol Metab. 2021 Apr 12. doi: 10.1152/ajpendo.00410.2020. Online ahead of print.ABSTRACTKetogenic diets (KD) are reported to improve body weight, fat mass, and exercise performance in humans. Unfortunately, most rodent studies have used a low-protein KD, which does not recapitulate diets used by humans. Since skeletal muscle plays a critical role in responding to macronutrient perturbations induced by diet and exercise, the purpose of this study was to test if a normal-protein KD (NPKD) impacts shifts in skeletal muscle substrate oxidative capacity in response to exercise training (ExTr). A high fat, car...
Source: Am J Physiol Endocri... - April 12, 2021 Category: Endocrinology Authors: Tai-Yu Huang Melissa A Linden Scott E Fuller Felicia R Goldsmith Jacob Simon Heidi M Batdorf Matthew C Scott Nabil M Essajee John M Brown Robert C Noland Source Type: research

Evaluation of glucagon-like peptide-1 receptor expression in non-diabetic and diabetic atherosclerotic mice using PET tracer < sup > 68 < /sup > Ga-NODAGA-exendin-4
Am J Physiol Endocrinol Metab. 2021 Apr 12. doi: 10.1152/ajpendo.00465.2020. Online ahead of print.ABSTRACTActivation of glucagon-like peptide-1 receptor (GLP-1R) signaling attenuates development of atherosclerosis and vascular inflammation. However, the expression of GLP-1R in atherosclerotic arteries remains uncertain. We evaluated whether a positron emission tomography (PET) tracer 68Ga-NODAGA-exendin-4 enables detection and imaging of GLP-1R expression in the mouse atherosclerotic aorta. Hypercholesterolemic (LDLR-/-ApoB100/100), hypercholesterolemic and diabetic (IGF-II/LDLR-/-ApoB100/100) as well as healthy control (...
Source: Am J Physiol Endocri... - April 12, 2021 Category: Endocrinology Authors: Mia St åhle Sanna Hellberg Jenni Virta Heidi Liljenb äck Olli Mets älä Xiang-Guo Li Matti Jauhiainen Pekka Saukko Seppo Yl ä-Herttuala Pirjo Nuutila Juhani Knuuti Antti Saraste Anne Roivainen Source Type: research

Counterpoint regarding an alternative hypothesis for why exposure to static magnetic and electric fields treat type 2 diabetes
Am J Physiol Endocrinol Metab. 2021 Apr 12. doi: 10.1152/ajpendo.00110.2021. Online ahead of print.ABSTRACTNot applicable.PMID:33843282 | DOI:10.1152/ajpendo.00110.2021 (Source: Am J Physiol Endocri...)
Source: Am J Physiol Endocri... - April 12, 2021 Category: Endocrinology Authors: Calvin S Carter Sunny Huang Charles Searby Benjamin Cassaidy Michael Miller Wojciech Grzesik Ted B Piorczynski Thomas K Pak Susan Walsh Michael Acevedo Qihong Zhang Kranti Mapuskar Ginger Milne Antentor Othrell Hinton Deng-Fu Guo Robert M Weiss Kyle Bradb Source Type: research

Response to: An alternative hypothesis for why exposure to static magnetic and electric fields treats type 2 diabetes
Am J Physiol Endocrinol Metab. 2021 Apr 12. doi: 10.1152/ajpendo.00119.2021. Online ahead of print.ABSTRACTn/a.PMID:33843283 | DOI:10.1152/ajpendo.00119.2021 (Source: Am J Physiol Endocri...)
Source: Am J Physiol Endocri... - April 12, 2021 Category: Endocrinology Authors: Calvin S Carter Sunny Huang Charles Searby Benjamin Cassaidy Michael Miller Wojciech Grzesik Ted B Piorczynski Thomas K Pak Susan Walsh Michael Acevedo Qihong Zhang Kranti Mapuskar Ginger Milne Antentor Othrell Hinton Deng-Fu Guo Robert M Weiss Kyle Bradb Source Type: research

An alternative hypothesis -- Response to Sheffield et al
Am J Physiol Endocrinol Metab. 2021 Apr 12. doi: 10.1152/ajpendo.00120.2021. Online ahead of print.ABSTRACTnot applicable.PMID:33843277 | DOI:10.1152/ajpendo.00120.2021 (Source: Am J Physiol Endocri...)
Source: Am J Physiol Endocri... - April 12, 2021 Category: Endocrinology Authors: Kitt Falk Petersen Douglas Rothman Gerald I Shulman Source Type: research

Proteome analysis of human adipocytes identifies depot-specific heterogeneity at metabolic control points
Am J Physiol Endocrinol Metab. 2021 Apr 12. doi: 10.1152/ajpendo.00473.2020. Online ahead of print.ABSTRACTAdipose tissue is a primary regulator of energy balance and metabolism. The distribution of adipose tissue depots is of clinical interest because the accumulation of upper-body subcutaneous (ASAT) and visceral adipose tissue (VAT) is associated with cardiometabolic diseases, whereas lower-body gluteal-femoral adipose tissue (GFAT) appears to be protective. There is heterogeneity in morphology and metabolism of adipocytes obtained from different regions of the body, but detailed knowledge of the constituent proteins in...
Source: Am J Physiol Endocri... - April 12, 2021 Category: Endocrinology Authors: Arthe Raajendiran Christoph Krisp David P De Souza Geraldine Ooi Paul R Burton Renea A Taylor Mark P Molloy Matthew J Watt Source Type: research

An alternative hypothesis for why exposure to static magnetic and electric fields treats type 2 diabetes
Am J Physiol Endocrinol Metab. 2021 Apr 12. doi: 10.1152/ajpendo.00657.2020. Online ahead of print.ABSTRACTCarter et al. report that exposure to static magnetic and electric fields (sBE), for as little as 3 days, reverses glucose intolerance and insulin resistance in diet-induced and genetic mouse models of type 2 diabetes (1). They hypothesize that sBE triggers a systemic redox response to modulate insulin sensitivity and that sBE could therefore be used as a noninvasive treatment for type 2 diabetes. However, these authors were unable to define a mechanism to explain how SBE might alter ROS or to identify the specific pr...
Source: Am J Physiol Endocri... - April 12, 2021 Category: Endocrinology Authors: Kitt Falk Petersen Douglas Rothman Gerald I Shulman Source Type: research

Combined effects of a ketogenic diet and exercise training alter mitochondrial and peroxisomal substrate oxidative capacity in skeletal muscle
Am J Physiol Endocrinol Metab. 2021 Apr 12. doi: 10.1152/ajpendo.00410.2020. Online ahead of print.ABSTRACTKetogenic diets (KD) are reported to improve body weight, fat mass, and exercise performance in humans. Unfortunately, most rodent studies have used a low-protein KD, which does not recapitulate diets used by humans. Since skeletal muscle plays a critical role in responding to macronutrient perturbations induced by diet and exercise, the purpose of this study was to test if a normal-protein KD (NPKD) impacts shifts in skeletal muscle substrate oxidative capacity in response to exercise training (ExTr). A high fat, car...
Source: Am J Physiol Endocri... - April 12, 2021 Category: Endocrinology Authors: Tai-Yu Huang Melissa A Linden Scott E Fuller Felicia R Goldsmith Jacob Simon Heidi M Batdorf Matthew C Scott Nabil M Essajee John M Brown Robert C Noland Source Type: research

Evaluation of glucagon-like peptide-1 receptor expression in non-diabetic and diabetic atherosclerotic mice using PET tracer < sup > 68 < /sup > Ga-NODAGA-exendin-4
Am J Physiol Endocrinol Metab. 2021 Apr 12. doi: 10.1152/ajpendo.00465.2020. Online ahead of print.ABSTRACTActivation of glucagon-like peptide-1 receptor (GLP-1R) signaling attenuates development of atherosclerosis and vascular inflammation. However, the expression of GLP-1R in atherosclerotic arteries remains uncertain. We evaluated whether a positron emission tomography (PET) tracer 68Ga-NODAGA-exendin-4 enables detection and imaging of GLP-1R expression in the mouse atherosclerotic aorta. Hypercholesterolemic (LDLR-/-ApoB100/100), hypercholesterolemic and diabetic (IGF-II/LDLR-/-ApoB100/100) as well as healthy control (...
Source: Am J Physiol Endocri... - April 12, 2021 Category: Endocrinology Authors: Mia St åhle Sanna Hellberg Jenni Virta Heidi Liljenb äck Olli Mets älä Xiang-Guo Li Matti Jauhiainen Pekka Saukko Seppo Yl ä-Herttuala Pirjo Nuutila Juhani Knuuti Antti Saraste Anne Roivainen Source Type: research

Counterpoint regarding an alternative hypothesis for why exposure to static magnetic and electric fields treat type 2 diabetes
Am J Physiol Endocrinol Metab. 2021 Apr 12. doi: 10.1152/ajpendo.00110.2021. Online ahead of print.ABSTRACTNot applicable.PMID:33843282 | DOI:10.1152/ajpendo.00110.2021 (Source: Am J Physiol Endocri...)
Source: Am J Physiol Endocri... - April 12, 2021 Category: Endocrinology Authors: Calvin S Carter Sunny Huang Charles Searby Benjamin Cassaidy Michael Miller Wojciech Grzesik Ted B Piorczynski Thomas K Pak Susan Walsh Michael Acevedo Qihong Zhang Kranti Mapuskar Ginger Milne Antentor Othrell Hinton Deng-Fu Guo Robert M Weiss Kyle Bradb Source Type: research

Response to: An alternative hypothesis for why exposure to static magnetic and electric fields treats type 2 diabetes
Am J Physiol Endocrinol Metab. 2021 Apr 12. doi: 10.1152/ajpendo.00119.2021. Online ahead of print.ABSTRACTn/a.PMID:33843283 | DOI:10.1152/ajpendo.00119.2021 (Source: Am J Physiol Endocri...)
Source: Am J Physiol Endocri... - April 12, 2021 Category: Endocrinology Authors: Calvin S Carter Sunny Huang Charles Searby Benjamin Cassaidy Michael Miller Wojciech Grzesik Ted B Piorczynski Thomas K Pak Susan Walsh Michael Acevedo Qihong Zhang Kranti Mapuskar Ginger Milne Antentor Othrell Hinton Deng-Fu Guo Robert M Weiss Kyle Bradb Source Type: research

Adrenal insufficiency in the COVID-19 era
Am J Physiol Endocrinol Metab. 2021 Apr 1;320(4):E784-E785. doi: 10.1152/ajpendo.00061.2021.NO ABSTRACTPMID:33825496 | DOI:10.1152/ajpendo.00061.2021 (Source: Am J Physiol Endocri...)
Source: Am J Physiol Endocri... - April 7, 2021 Category: Endocrinology Authors: Agnieszka Siejka Nektarios Barabutis Source Type: research

Adrenal insufficiency in the COVID-19 era
Am J Physiol Endocrinol Metab. 2021 Apr 1;320(4):E784-E785. doi: 10.1152/ajpendo.00061.2021.NO ABSTRACTPMID:33825496 | DOI:10.1152/ajpendo.00061.2021 (Source: Am J Physiol Endocri...)
Source: Am J Physiol Endocri... - April 7, 2021 Category: Endocrinology Authors: Agnieszka Siejka Nektarios Barabutis Source Type: research

Adrenal insufficiency in the COVID-19 era
Am J Physiol Endocrinol Metab. 2021 Apr 1;320(4):E784-E785. doi: 10.1152/ajpendo.00061.2021.NO ABSTRACTPMID:33825496 | DOI:10.1152/ajpendo.00061.2021 (Source: Am J Physiol Endocri...)
Source: Am J Physiol Endocri... - April 7, 2021 Category: Endocrinology Authors: Agnieszka Siejka Nektarios Barabutis Source Type: research

Adrenal insufficiency in the COVID-19 era
Am J Physiol Endocrinol Metab. 2021 Apr 1;320(4):E784-E785. doi: 10.1152/ajpendo.00061.2021.NO ABSTRACTPMID:33825496 | DOI:10.1152/ajpendo.00061.2021 (Source: Am J Physiol Endocri...)
Source: Am J Physiol Endocri... - April 7, 2021 Category: Endocrinology Authors: Agnieszka Siejka Nektarios Barabutis Source Type: research

Adrenal insufficiency in the COVID-19 era
Am J Physiol Endocrinol Metab. 2021 Apr 1;320(4):E784-E785. doi: 10.1152/ajpendo.00061.2021.NO ABSTRACTPMID:33825496 | DOI:10.1152/ajpendo.00061.2021 (Source: Am J Physiol Endocri...)
Source: Am J Physiol Endocri... - April 7, 2021 Category: Endocrinology Authors: Agnieszka Siejka Nektarios Barabutis Source Type: research

Enoyl coenzyme A hydratase 1 alleviates nonalcoholic steatohepatitis in mice by suppressing hepatic ferroptosis
Am J Physiol Endocrinol Metab. 2021 Apr 5. doi: 10.1152/ajpendo.00614.2020. Online ahead of print.ABSTRACTNon-alcoholic steatohepatitis (NASH) is a common metabolic disorder that is a major contributor to health care expenditures worldwide. Enoyl coenzyme A hydratase 1 (ECH1) is initially recognized as a key component in mitochondrial fatty acid β-oxidation, and subsequent studies have demonstrated that it regulates multiple pathophysiological processes. However, the relationship between ECH1 and NASH has remained largely unknown. Herein, we investigated the role of ECH1 in NASH progression. Adeno-associated virus-med...
Source: Am J Physiol Endocri... - April 5, 2021 Category: Endocrinology Authors: Bing Liu Wei Yi Xiaoxiang Mao Ling Yang Caijun Rao Source Type: research

Importance of the route of insulin delivery to its control of glucose metabolism
Am J Physiol Endocrinol Metab. 2021 Apr 5. doi: 10.1152/ajpendo.00628.2020. Online ahead of print.ABSTRACTPancreatic insulin secretion produces an insulin gradient at the liver compared to the rest of the body (approximately 3:1). This physiologic distribution is lost when insulin is injected subcutaneously, causing impaired regulation of hepatic glucose production and whole body glucose uptake, as well as arterial hyperinsulinemia. Thus, the hepatoportal insulin gradient is essential to the normal control of glucose metabolism during both fasting and feeding. Insulin can regulate hepatic glucose production and uptake thro...
Source: Am J Physiol Endocri... - April 5, 2021 Category: Endocrinology Authors: Dale S Edgerton Mary Courtney Moore Justin M Gregory Guillaume Kraft Alan D Cherrington Source Type: research

Genetically increasing flux through β-oxidation in skeletal muscle increases mitochondrial reductive stress and glucose intolerance
Am J Physiol Endocrinol Metab. 2021 Apr 5. doi: 10.1152/ajpendo.00010.2021. Online ahead of print.ABSTRACTElevated mitochondrial H2O2 emission and an oxidative shift in cytosolic redox environment have been linked to high fat diet-induced insulin resistance in skeletal muscle. To test specifically whether increased flux through mitochondrial fatty acid oxidation, in the absence of elevated energy demand, directly alters mitochondrial function and redox state in muscle, two genetic models characterized by increased muscle β-oxidation flux were studied. In mice overexpressing peroxisome proliferator activated receptor-&...
Source: Am J Physiol Endocri... - April 5, 2021 Category: Endocrinology Authors: Cody D Smith Chein-Te Lin Shawna L McMillin Luke A Weyrauch Cameron Alan Schmidt Cheryl A Smith Irwin J Kurland Carol A Witczak P Darrell Neufer Source Type: research

Enoyl coenzyme A hydratase 1 alleviates nonalcoholic steatohepatitis in mice by suppressing hepatic ferroptosis
Am J Physiol Endocrinol Metab. 2021 Apr 5. doi: 10.1152/ajpendo.00614.2020. Online ahead of print.ABSTRACTNon-alcoholic steatohepatitis (NASH) is a common metabolic disorder that is a major contributor to health care expenditures worldwide. Enoyl coenzyme A hydratase 1 (ECH1) is initially recognized as a key component in mitochondrial fatty acid β-oxidation, and subsequent studies have demonstrated that it regulates multiple pathophysiological processes. However, the relationship between ECH1 and NASH has remained largely unknown. Herein, we investigated the role of ECH1 in NASH progression. Adeno-associated virus-med...
Source: Am J Physiol Endocri... - April 5, 2021 Category: Endocrinology Authors: Bing Liu Wei Yi Xiaoxiang Mao Ling Yang Caijun Rao Source Type: research

Importance of the route of insulin delivery to its control of glucose metabolism
Am J Physiol Endocrinol Metab. 2021 Apr 5. doi: 10.1152/ajpendo.00628.2020. Online ahead of print.ABSTRACTPancreatic insulin secretion produces an insulin gradient at the liver compared to the rest of the body (approximately 3:1). This physiologic distribution is lost when insulin is injected subcutaneously, causing impaired regulation of hepatic glucose production and whole body glucose uptake, as well as arterial hyperinsulinemia. Thus, the hepatoportal insulin gradient is essential to the normal control of glucose metabolism during both fasting and feeding. Insulin can regulate hepatic glucose production and uptake thro...
Source: Am J Physiol Endocri... - April 5, 2021 Category: Endocrinology Authors: Dale S Edgerton Mary Courtney Moore Justin M Gregory Guillaume Kraft Alan D Cherrington Source Type: research

Genetically increasing flux through β-oxidation in skeletal muscle increases mitochondrial reductive stress and glucose intolerance
Am J Physiol Endocrinol Metab. 2021 Apr 5. doi: 10.1152/ajpendo.00010.2021. Online ahead of print.ABSTRACTElevated mitochondrial H2O2 emission and an oxidative shift in cytosolic redox environment have been linked to high fat diet-induced insulin resistance in skeletal muscle. To test specifically whether increased flux through mitochondrial fatty acid oxidation, in the absence of elevated energy demand, directly alters mitochondrial function and redox state in muscle, two genetic models characterized by increased muscle β-oxidation flux were studied. In mice overexpressing peroxisome proliferator activated receptor-&...
Source: Am J Physiol Endocri... - April 5, 2021 Category: Endocrinology Authors: Cody D Smith Chein-Te Lin Shawna L McMillin Luke A Weyrauch Cameron Alan Schmidt Cheryl A Smith Irwin J Kurland Carol A Witczak P Darrell Neufer Source Type: research

Liver glycogen-induced enhancements in hypoglycemic counterregulation require neuroglucopenia
Am J Physiol Endocrinol Metab. 2021 Mar 29. doi: 10.1152/ajpendo.00501.2020. Online ahead of print.ABSTRACTIatrogenic hypoglycemia is a prominent barrier to achieving optimal glycemic control in patients with diabetes, in part due to dampened counterregulatory hormone responses. It has been demonstrated that elevated liver glycogen content can enhance these hormonal responses through signaling to the brain via afferent nerves, but the role that hypoglycemia in the brain plays in this liver glycogen effect remains unclear. During the first 4hrs of each study, the liver glycogen content of dogs was increased by using an intr...
Source: Am J Physiol Endocri... - March 29, 2021 Category: Endocrinology Authors: Shana O Warner Abby M Wadian Marta S Smith Ben Farmer Yufei Dai Nicole Sheanon Dale S Edgerton Jason J Winnick Source Type: research

In vitro chronic glycation induces AGEs accumulation reducing insulin stimulated glucose uptake and increasing GLP1R in adipocytes
Am J Physiol Endocrinol Metab. 2021 Mar 29. doi: 10.1152/ajpendo.00156.2020. Online ahead of print.ABSTRACTGlycation is one of the most important post-translational modifications in cells and tissues and gives rise to highly reactive species called advanced glycation end products (AGEs). AGEs exert their pathological effects through different ways and previous reports suggest that they may also affect adipose tissue function and insulin sensitivity. All the data belong only to short-term treatments; however, in vivo glycation is a continuous process. To fill this gap, our study investigated the effect of chronic pro-glycat...
Source: Am J Physiol Endocri... - March 29, 2021 Category: Endocrinology Authors: Nino C Chilelli Alessia Faggian Francesca Favaretto Gabriella Milan Chiara Compagnin Francesca Dassie Silvia Bettini Marco Roverso Roberta Seraglia Annunziata Lapolla Roberto Vettor Source Type: research

Liver glycogen-induced enhancements in hypoglycemic counterregulation require neuroglucopenia
Am J Physiol Endocrinol Metab. 2021 Mar 29. doi: 10.1152/ajpendo.00501.2020. Online ahead of print.ABSTRACTIatrogenic hypoglycemia is a prominent barrier to achieving optimal glycemic control in patients with diabetes, in part due to dampened counterregulatory hormone responses. It has been demonstrated that elevated liver glycogen content can enhance these hormonal responses through signaling to the brain via afferent nerves, but the role that hypoglycemia in the brain plays in this liver glycogen effect remains unclear. During the first 4hrs of each study, the liver glycogen content of dogs was increased by using an intr...
Source: Am J Physiol Endocri... - March 29, 2021 Category: Endocrinology Authors: Shana O Warner Abby M Wadian Marta S Smith Ben Farmer Yufei Dai Nicole Sheanon Dale S Edgerton Jason J Winnick Source Type: research

In vitro chronic glycation induces AGEs accumulation reducing insulin stimulated glucose uptake and increasing GLP1R in adipocytes
Am J Physiol Endocrinol Metab. 2021 Mar 29. doi: 10.1152/ajpendo.00156.2020. Online ahead of print.ABSTRACTGlycation is one of the most important post-translational modifications in cells and tissues and gives rise to highly reactive species called advanced glycation end products (AGEs). AGEs exert their pathological effects through different ways and previous reports suggest that they may also affect adipose tissue function and insulin sensitivity. All the data belong only to short-term treatments; however, in vivo glycation is a continuous process. To fill this gap, our study investigated the effect of chronic pro-glycat...
Source: Am J Physiol Endocri... - March 29, 2021 Category: Endocrinology Authors: Nino C Chilelli Alessia Faggian Francesca Favaretto Gabriella Milan Chiara Compagnin Francesca Dassie Silvia Bettini Marco Roverso Roberta Seraglia Annunziata Lapolla Roberto Vettor Source Type: research

Liver glycogen-induced enhancements in hypoglycemic counterregulation require neuroglucopenia
Am J Physiol Endocrinol Metab. 2021 Mar 29. doi: 10.1152/ajpendo.00501.2020. Online ahead of print.ABSTRACTIatrogenic hypoglycemia is a prominent barrier to achieving optimal glycemic control in patients with diabetes, in part due to dampened counterregulatory hormone responses. It has been demonstrated that elevated liver glycogen content can enhance these hormonal responses through signaling to the brain via afferent nerves, but the role that hypoglycemia in the brain plays in this liver glycogen effect remains unclear. During the first 4hrs of each study, the liver glycogen content of dogs was increased by using an intr...
Source: Am J Physiol Endocri... - March 29, 2021 Category: Endocrinology Authors: Shana O Warner Abby M Wadian Marta S Smith Ben Farmer Yufei Dai Nicole Sheanon Dale S Edgerton Jason J Winnick Source Type: research

In vitro chronic glycation induces AGEs accumulation reducing insulin stimulated glucose uptake and increasing GLP1R in adipocytes
Am J Physiol Endocrinol Metab. 2021 Mar 29. doi: 10.1152/ajpendo.00156.2020. Online ahead of print.ABSTRACTGlycation is one of the most important post-translational modifications in cells and tissues and gives rise to highly reactive species called advanced glycation end products (AGEs). AGEs exert their pathological effects through different ways and previous reports suggest that they may also affect adipose tissue function and insulin sensitivity. All the data belong only to short-term treatments; however, in vivo glycation is a continuous process. To fill this gap, our study investigated the effect of chronic pro-glycat...
Source: Am J Physiol Endocri... - March 29, 2021 Category: Endocrinology Authors: Nino C Chilelli Alessia Faggian Francesca Favaretto Gabriella Milan Chiara Compagnin Francesca Dassie Silvia Bettini Marco Roverso Roberta Seraglia Annunziata Lapolla Roberto Vettor Source Type: research

Liver glycogen-induced enhancements in hypoglycemic counterregulation require neuroglucopenia
Am J Physiol Endocrinol Metab. 2021 Mar 29. doi: 10.1152/ajpendo.00501.2020. Online ahead of print.ABSTRACTIatrogenic hypoglycemia is a prominent barrier to achieving optimal glycemic control in patients with diabetes, in part due to dampened counterregulatory hormone responses. It has been demonstrated that elevated liver glycogen content can enhance these hormonal responses through signaling to the brain via afferent nerves, but the role that hypoglycemia in the brain plays in this liver glycogen effect remains unclear. During the first 4hrs of each study, the liver glycogen content of dogs was increased by using an intr...
Source: Am J Physiol Endocri... - March 29, 2021 Category: Endocrinology Authors: Shana O Warner Abby M Wadian Marta S Smith Ben Farmer Yufei Dai Nicole Sheanon Dale S Edgerton Jason J Winnick Source Type: research

In vitro chronic glycation induces AGEs accumulation reducing insulin stimulated glucose uptake and increasing GLP1R in adipocytes
Am J Physiol Endocrinol Metab. 2021 Mar 29. doi: 10.1152/ajpendo.00156.2020. Online ahead of print.ABSTRACTGlycation is one of the most important post-translational modifications in cells and tissues and gives rise to highly reactive species called advanced glycation end products (AGEs). AGEs exert their pathological effects through different ways and previous reports suggest that they may also affect adipose tissue function and insulin sensitivity. All the data belong only to short-term treatments; however, in vivo glycation is a continuous process. To fill this gap, our study investigated the effect of chronic pro-glycat...
Source: Am J Physiol Endocri... - March 29, 2021 Category: Endocrinology Authors: Nino C Chilelli Alessia Faggian Francesca Favaretto Gabriella Milan Chiara Compagnin Francesca Dassie Silvia Bettini Marco Roverso Roberta Seraglia Annunziata Lapolla Roberto Vettor Source Type: research

Liver glycogen-induced enhancements in hypoglycemic counterregulation require neuroglucopenia
Am J Physiol Endocrinol Metab. 2021 Mar 29. doi: 10.1152/ajpendo.00501.2020. Online ahead of print.ABSTRACTIatrogenic hypoglycemia is a prominent barrier to achieving optimal glycemic control in patients with diabetes, in part due to dampened counterregulatory hormone responses. It has been demonstrated that elevated liver glycogen content can enhance these hormonal responses through signaling to the brain via afferent nerves, but the role that hypoglycemia in the brain plays in this liver glycogen effect remains unclear. During the first 4hrs of each study, the liver glycogen content of dogs was increased by using an intr...
Source: Am J Physiol Endocri... - March 29, 2021 Category: Endocrinology Authors: Shana O Warner Abby M Wadian Marta S Smith Ben Farmer Yufei Dai Nicole Sheanon Dale S Edgerton Jason J Winnick Source Type: research

In vitro chronic glycation induces AGEs accumulation reducing insulin stimulated glucose uptake and increasing GLP1R in adipocytes
Am J Physiol Endocrinol Metab. 2021 Mar 29. doi: 10.1152/ajpendo.00156.2020. Online ahead of print.ABSTRACTGlycation is one of the most important post-translational modifications in cells and tissues and gives rise to highly reactive species called advanced glycation end products (AGEs). AGEs exert their pathological effects through different ways and previous reports suggest that they may also affect adipose tissue function and insulin sensitivity. All the data belong only to short-term treatments; however, in vivo glycation is a continuous process. To fill this gap, our study investigated the effect of chronic pro-glycat...
Source: Am J Physiol Endocri... - March 29, 2021 Category: Endocrinology Authors: Nino C Chilelli Alessia Faggian Francesca Favaretto Gabriella Milan Chiara Compagnin Francesca Dassie Silvia Bettini Marco Roverso Roberta Seraglia Annunziata Lapolla Roberto Vettor Source Type: research

Liver glycogen-induced enhancements in hypoglycemic counterregulation require neuroglucopenia
Am J Physiol Endocrinol Metab. 2021 Mar 29. doi: 10.1152/ajpendo.00501.2020. Online ahead of print.ABSTRACTIatrogenic hypoglycemia is a prominent barrier to achieving optimal glycemic control in patients with diabetes, in part due to dampened counterregulatory hormone responses. It has been demonstrated that elevated liver glycogen content can enhance these hormonal responses through signaling to the brain via afferent nerves, but the role that hypoglycemia in the brain plays in this liver glycogen effect remains unclear. During the first 4hrs of each study, the liver glycogen content of dogs was increased by using an intr...
Source: Am J Physiol Endocri... - March 29, 2021 Category: Endocrinology Authors: Shana O Warner Abby M Wadian Marta S Smith Ben Farmer Yufei Dai Nicole Sheanon Dale S Edgerton Jason J Winnick Source Type: research