Relation of Diet-Induced Thermogenesis to Brown Adipose Tissue Activity in Healthy Men.
Abstract Objective Human brown adipose tissue (BAT) is a thermogenic tissue activated by the sympathetic nervous system in response to cold. It contributes to energy expenditure (EE) and takes up glucose and lipids from the circulation. Studies in rodents suggest that BAT contributes to the transient rise in EE after food intake, so called diet-induced thermogenesis (DIT). We investigated the relationship between human BAT activity and DIT in response to glucose intake in 17 healthy volunteers. Methods We assessed DIT, cold induced thermogenesis (CIT) and maximum BAT activity at three separate study visits within ...
Source: Am J Physiol Endocri... - November 23, 2020 Category: Endocrinology Authors: Loeliger RC, Maushart CI, Gashi G, Senn JR, Felder M, Becker AS, Mueller JB, Balaz M, Wolfrum C, Burger IA, Betz MJ Tags: Am J Physiol Endocrinol Metab Source Type: research

Arginine site 264 in murine estrogen receptor alpha is dispensable for the regulation of the skeleton.
In conclusion, our novel finding that mutation of R264 in ERα does not affect the regulation of the skeleton, together with the known role of R264 for ERα-mediated endothelial effects, supports the concept that R264 determines tissue specificity of ERα. PMID: 33225718 [PubMed - as supplied by publisher] (Source: Am J Physiol Endocri...)
Source: Am J Physiol Endocri... - November 23, 2020 Category: Endocrinology Authors: Gustafsson KL, Farman HH, Nilsson KH, Henning P, Movérare-Skrtic S, Lionikaite V, Lawenius L, Engdahl C, Ohlsson C, Lagerquist MK Tags: Am J Physiol Endocrinol Metab Source Type: research

ChREBP downregulates SNAT2 amino acid transporter expression through interactions with SMRT in response to a high-carbohydrate diet.
rres N, Ortiz-Ortega VM Abstract ChREBP has been identified as a primary transcription factor that maintains energy homeostasis through transcriptional regulation of glycolytic, lipogenic and gluconeogenic enzymes in response to a high-carbohydrate diet. Amino acids are important substrates for gluconeogenesis, but nevertheless, knowledge is lacking about whether this transcription factor regulates genes involved in the transport or use of these metabolites. Here, we demonstrate that ChREBP represses the expression of the amino acid transporter SNAT2 in response to a high-sucrose diet in rats by binding to a ChoRE...
Source: Am J Physiol Endocri... - November 23, 2020 Category: Endocrinology Authors: Velázquez-Villegas L, Noriega LG, López-Barradas A, Tobon-Cornejo S, Méndez-García AL, Tovar AR, Torres N, Ortiz-Ortega VM Tags: Am J Physiol Endocrinol Metab Source Type: research

Eicosapentaenoic acid changes muscle transcriptome and intervenes in aging-related fiber type transition in male mice.
In conclusion, we revealed that aging skeletal muscle in male mice- shows lower grip strength and fiber type changes, both of which can be inhibited by EPA supplementation irrespective of muscle mass alteration. PMID: 33225720 [PubMed - as supplied by publisher] (Source: Am J Physiol Endocri...)
Source: Am J Physiol Endocri... - November 23, 2020 Category: Endocrinology Authors: Yamazaki H, Nishimura M, Uehara M, Kuribara-Souta A, Yamamoto M, Yoshikawa N, Morohashi KI, Tanaka H Tags: Am J Physiol Endocrinol Metab Source Type: research

Gq α/G11α deficiency in dorsomedial hypothalamus leads to obesity resulting from decreased energy expenditure and impaired sympathetic nerve activity.
In this study we investigated the consequences of Gq/11α deficiency in the dorsomedial hypothalamus (DMH), a critical site for the control of energy homeostasis. Mice with DMH-specific deletion of Gq/11α (DMHGq/11KO) were generated by stereotaxic injection of AAV-Cre-GFP into the DMH of Gqαflox/flox:G11α-/- mice. Compared to control mice that received DMH injection of AAV-GFP, DMHGq/11KO mice developed obesity associated with reduced energy expenditure without significant changes in food intake or physical activity. DMHGq/11KO mice showed no defects in the ability of the melanocortin agonist melanot...
Source: Am J Physiol Endocri... - November 9, 2020 Category: Endocrinology Authors: Wilson EA, Sun H, Cui Z, Jahnke MT, Pandey M, Metzger P, Gavrilova O, Chen M, Weinstein LS Tags: Am J Physiol Endocrinol Metab Source Type: research

Alterations of Gut Microbiome in Type 2 Diabetes Mellitus Patients Undergone Cholecystectomy.
In this study, the gut microbiomes of 14 long-term T2DM patients who had undergone cholecystectomy (T2DIIC group) and 21 age- and/or sex-matched subjects with new-onset (T2DI group) and long-term (T2DII group) T2DM without cholecystectomy were assessed using 16S rRNA gene sequencing of stool samples. It was found that cholecystectomy could alleviate the decrease in Pielou's evenness and the increase in the relative abundances of the Firmicutes phylum and Lachnospira genus in long-term T2DM patients compared with that observed in the T2DII subjects. Moreover, cholecystectomy also significantly increased the relative abundan...
Source: Am J Physiol Endocri... - November 9, 2020 Category: Endocrinology Authors: Wei B, Wang Y, Xiang S, Jiang Y, Chen R, Hu N Tags: Am J Physiol Endocrinol Metab Source Type: research

Is GLUT4 translocation the answer to exercise stimulated muscle glucose uptake?
Abstract Exercise increases muscle glucose uptake up to 100 fold compared to rest. The magnitude of increase depends on exercise intensity and duration. While KO of GLUT4 convincingly has shown that GLUT4 is necessary for exercise to increase muscle glucose uptake, studies only show an approximate 2-fold increase in GLUT4 translocation to the muscle cell membrane when transitioning from rest to exercise. Therefore, there is a big discrepancy between the increase in glucose uptake and GLUT4 translocation. It is suggested that either the methods for measurements of GLUT4 translocation in muscle grossly underestimate...
Source: Am J Physiol Endocri... - November 9, 2020 Category: Endocrinology Authors: Richter EA Tags: Am J Physiol Endocrinol Metab Source Type: research

Am J Physiol Endocrinol Metab; +60 new citations
60 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Endocrinol Metab These pubmed results were generated on 2020/10/28PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. (Source: Am J Physiol Endocri...)
Source: Am J Physiol Endocri... - October 28, 2020 Category: Endocrinology Tags: Report Source Type: research

Mitochondria-associated ER membranes in glucose homeostasis and insulin resistance.
Abstract Obesity and insulin resistance (IR) are associated with endoplasmic reticulum (ER) stress and mitochondrial dysfunction in several tissues. Although for many years mitochondrial and ER function were studied separately, these organelles also connect to produce interdependent functions. Communication occurs at mitochondria-associated ER membranes (MAM) and regulates lipid and calcium homeostasis, apoptosis, and the exchange of adenine nucleotides, among other things. Recent evidence suggests that MAMs contribute to organelle, cellular, and systemic metabolism. In obesity and IR models, metabolic tissues suc...
Source: Am J Physiol Endocri... - September 27, 2020 Category: Endocrinology Authors: Townsend LK, Brunetta BS, Mori MA Tags: Am J Physiol Endocrinol Metab Source Type: research

A ketogenic diet combined with exercise alters mitochondrial function in human skeletal muscle while improving metabolic health.
A KETOGENIC DIET COMBINED WITH EXERCISE ALTERS MITOCHONDRIAL FUNCTION IN HUMAN SKELETAL MUSCLE WHILE IMPROVING METABOLIC HEALTH. Am J Physiol Endocrinol Metab. 2020 Sep 28;: Authors: Miller VJ, LaFountain RA, Barnhart E, Sapper TS, Short J, Arnold WD, Hyde PN, Crabtree CD, Kackley ML, Kraemer WJ, Villamena F, Volek JS Abstract Animal data indicate that ketogenic diets are associated with improved mitochondrial function, but human data are lacking. We aimed to characterize skeletal muscle mitochondrial changes in response to a ketogenic diet combined with exercise training in healthy individuals. Twent...
Source: Am J Physiol Endocri... - September 27, 2020 Category: Endocrinology Authors: Miller VJ, LaFountain RA, Barnhart E, Sapper TS, Short J, Arnold WD, Hyde PN, Crabtree CD, Kackley ML, Kraemer WJ, Villamena F, Volek JS Tags: Am J Physiol Endocrinol Metab Source Type: research

GLP-1 Alleviates Diabetic Kidney Disease Through Activation of Autophagy by Regulating AMPK/mTOR Pathway.
Abstract Glucagon-like peptide-1 (GLP-1) is a novel anti-diabetic agent used in clinical practice. Recently, it was reported to exert a renoprotective effect in the HK-2 cells and kidneys of diabetic rats, which was induced by one type of GLP-1 analogues liraglutide in the presence of high glucose. However, most of the previous findings mainly focused on its indirect effect in inhibiting the advanced glycation end products. Here, besides glycemic control, we also demonstrated a stimulatory role of liraglutide in promoting autophagy and relieving oxidative stress in Zucker diabetic fatty(ZDF) rats. The renoprotecti...
Source: Am J Physiol Endocri... - September 27, 2020 Category: Endocrinology Authors: Yang S, Lin C, Zhuo X, Wang J, Rao S, Xu W, Cheng Y, Yang L Tags: Am J Physiol Endocrinol Metab Source Type: research

Modulation of the inflammatory response to LPS by the recruitment and activation of brown and brite adipocytes in mice.
CONCLUSION: In conclusion, these results suggest an IL-1RA-mediated immunomodulatory activity of thermogenic adipocytes specifically in response to endotoxaemia. This encourages potential therapy involving brown and brite adipocytes for the treatment of obesity and associated metabolic diseases. PMID: 32954821 [PubMed - as supplied by publisher] (Source: Am J Physiol Endocri...)
Source: Am J Physiol Endocri... - September 20, 2020 Category: Endocrinology Authors: Munro P, Dufies O, Rekima S, Loubat A, Duranton C, Boyer L, Pisani DF Tags: Am J Physiol Endocrinol Metab Source Type: research

Role of creatine and creatine kinase in UCP1-independent adipocyte thermogenesis.
Abstract During recent years, creatine kinase (CK) and its substrates phosphocreatine and creatine emerged as important players in uncoupling protein 1-independent, ATP-dependent non-shivering thermogenesis in beige/brown adipocytes. The exact thermogenic mechanism, that is facilitated by the CK system, however, still remains elusive. A futile creatine-cycling mechanism functioning via a hypothetical phosphocreatine phosphatase has been proposed. However, the molecular basis of such cycling remained elusive, so far. Here, we tend to argue for an alternative mechanism based on the classical CK/phosphocreatine shutt...
Source: Am J Physiol Endocri... - September 20, 2020 Category: Endocrinology Authors: Wallimann TA, Tokarska-Schlattner M, Kay L, Schlattner U Tags: Am J Physiol Endocrinol Metab Source Type: research

Vascular endothelial growth factor B promotes transendothelial fatty acid transport into skeletal muscle via histone modifications during catch-up growth.
Abstract Caloric restriction (CR) followed by refeeding, a phenomenon known as catch-up growth (CUG), results in excessive lipid deposition and insulin resistance in skeletal muscle, but the underlying mechanisms remain elusive. Recent reports have suggested that vascular endothelial growth factor B (VEGF-B) controls muscle lipid accumulation by regulating endothelial fatty acid transport. Here, we found continuous activation of VEGF-B signaling and increased lipid uptake in skeletal muscle from CR to refeeding, as well as increased lipid deposition and impaired insulin sensitivity after refeeding in the skeletal ...
Source: Am J Physiol Endocri... - September 20, 2020 Category: Endocrinology Authors: Lu X, Hu S, Liao Y, Zheng J, Zeng T, Zhong X, Liu G, Chen L, Chen L Tags: Am J Physiol Endocrinol Metab Source Type: research

Maternal Hypercortisolemia alters ovine placental metabolism: a multi-omics view.
Abstract Previous studies have suggested that increases in maternal cortisol or maternal stress in late pregnancy increase the risk of stillbirth at term. In an ovine model with increased maternal cortisol over the last 0.20 of gestation, we have previously found evidence of disruption of fetal serum and cardiac metabolomics, and of expression of genes related to mitochondrial function and metabolism in biceps femoris, diaphragm and cardiac muscle. The present studies were designed to test for effects of chronically increased maternal cortisol on gene expression and metabolomics in placentomes near term. We hypoth...
Source: Am J Physiol Endocri... - September 20, 2020 Category: Endocrinology Authors: Joseph S, Walejko JM, Zhang S, Edison AS, Keller-Wood M Tags: Am J Physiol Endocrinol Metab Source Type: research

Long-chain acyl-CoA synthetase 1 mediates the palmitic acid-induced inflammatory response in human aortic endothelial cells.
Abstract Saturated fatty acid (SFA) induces pro-inflammatory response through a toll-like receptor (TLR)-mediated mechanism, which is associated with cardiometabolic diseases such as obesity, insulin resistance, and endothelial dysfunction. Consistent with this notion, TLR2 or TLR4 knock-out mice are protected from obesity-induced pro-inflammatory response and endothelial dysfunction. Although SFA causes endothelial dysfunction through TLR-mediated signaling pathways, the mechanisms underlying SFA-stimulated inflammatory response are not completely understood. To understand the pro-inflammatory response in vascula...
Source: Am J Physiol Endocri... - September 20, 2020 Category: Endocrinology Authors: Ren G, Bhatnagar S, Hahn DJ, Kim JA Tags: Am J Physiol Endocrinol Metab Source Type: research

Mitochondrial Transformations in the Ageing Human Placenta.
Abstract Mitochondria play a key role in homeostasis and are central to one of the leading hypotheses of ageing, the free radical theory. Mitochondria function as a reticulated network, constantly adapting to the cellular environment through fusion (joining), biogenesis (formation of new mitochondria) and fission (separation). This adaptive response is particularly important in response to oxidative stress, cellular damage and ageing, when mitochondria are selectively removed through mitophagy, a mitochondrial equivalent of autophagy. During this complex process, mitochondria influence surrounding cell biology and...
Source: Am J Physiol Endocri... - September 20, 2020 Category: Endocrinology Authors: Bartho LA, Fisher JJ, Cuffe JS, Perkins AV Tags: Am J Physiol Endocrinol Metab Source Type: research

Visualizing and quantifying cutaneous microvascular reactivity in humans using optical coherence tomography: Impaired dilator function in diabetes.
Abstract The pathophysiology and timecourse of impairment in cutaneous microcirculatory function and structure remain poorly understood in diabetics, partly due to the lack of investigational tools capable of directly imaging and quantifying the microvasculature in vivo. We applied a new optical coherence tomography (OCT) technique, at rest and during reactive hyperemia (RH), to assess the skin microvasculature in diabetic people with foot ulcers (DFU, n=13), diabetics without ulcers (DNU, n=9) and matched healthy controls (CON, n=13). OCT images were obtained from the dorsal part of the foot, at rest and 30 secon...
Source: Am J Physiol Endocri... - September 20, 2020 Category: Endocrinology Authors: Argarini R, McLaughlin RA, Joseph SZ, Naylor LH, Carter HH, Haynes A, Marsh CE, Yeap BB, Jansen SJ, Green DJ Tags: Am J Physiol Endocrinol Metab Source Type: research

Mechanism of futile creatine cycling in thermogenesis.
PMID: 32954828 [PubMed - as supplied by publisher] (Source: Am J Physiol Endocri...)
Source: Am J Physiol Endocri... - September 20, 2020 Category: Endocrinology Authors: Kazak L, Spiegelman BM Tags: Am J Physiol Endocrinol Metab Source Type: research

An obesogenic maternal environment impairs mouse growth patterns, satellite cell activation and markers of post-natal myogenesis.
In this study, we investigated the effect of an obesogenic maternal environment on growth and post-natal myogenesis in the offspring. Male C57BL/6J mice born to chow or high-fat fed mothers were allocated to four different groups at the end of weaning. For the following ten weeks, half of the pups were maintained on the same diet as their mother and half of the pups were switched to the other diet (chow or high-fat). At 12 weeks of age, muscle injury was induced using an intramuscular injection of barium chloride. Seven days later, mice were humanely killed and muscle tissue was harvested. A high-fat maternal diet impaired...
Source: Am J Physiol Endocri... - September 20, 2020 Category: Endocrinology Authors: Mikovic J, Brightwell CR, Lindsay A, Wen Y, Kowalski G, Russell AP, Fry CS, Lamon S Tags: Am J Physiol Endocrinol Metab Source Type: research

Differences in metabolic and liver pathobiology induced by two dietary mouse models of nonalcoholic fatty liver disease.
In conclusion, long-term feeding of either HFHF or WDHC are reliable methods to induce NASH and diet-potentiated liver cancer in mice of both sexes; however, the choice of diet involves a trade-off between severity of metabolic syndrome and liver damage. PMID: 32924526 [PubMed - as supplied by publisher] (Source: Am J Physiol Endocri...)
Source: Am J Physiol Endocri... - September 13, 2020 Category: Endocrinology Authors: Zhang H, Léveillé M, Courty E, Gunes A, Nguyen B, Estall JL Tags: Am J Physiol Endocrinol Metab Source Type: research

Astragaloside IV ameliorates preeclampsia-induced oxidative stress through Nrf2/HO-1 pathway in a rat model.
Abstract Preeclampsia (PE) can cause serious health problems for pregnant women and their infants. Astragaloside IV has been shown to exert cardioprotective, anti-inflammatory, and anti-oxidative effects on various disorders. We aimed to study the effects of Astragaloside IV on PE symptoms using an NG-Nitro-L-arginine-methyl ester (L-NAME)-induced rat model of PE. The pregnant rats' physiological features, including blood pressure, urine protein, serum sFlt-1/PIGF ratio, and weight of placenta, as well as the weight, length, and survival of pups, were documented. The expression levels of target genes were analyzed...
Source: Am J Physiol Endocri... - September 13, 2020 Category: Endocrinology Authors: Yang S, Zhang R, Xing B, Zhou L, Zhang P, Song L Tags: Am J Physiol Endocrinol Metab Source Type: research

Corrigendum.
Authors: PMID: 32903030 [PubMed - in process] (Source: Am J Physiol Endocri...)
Source: Am J Physiol Endocri... - August 31, 2020 Category: Endocrinology Tags: Am J Physiol Endocrinol Metab Source Type: research

Reply to Jakovac and to Rocha et al.: Can vitamin D prevent or manage COVID-19 illness?
PMID: 32787704 [PubMed - in process] (Source: Am J Physiol Endocri...)
Source: Am J Physiol Endocri... - July 31, 2020 Category: Endocrinology Authors: Slominski AT, Slominski RM, Goepfert PA, Kim TK, Holick MF, Jetten AM, Raman C Tags: Am J Physiol Endocrinol Metab Source Type: research

Reply to Jakovac: COVID-19, vitamin D, and type I interferon.
PMID: 32672049 [PubMed - in process] (Source: Am J Physiol Endocri...)
Source: Am J Physiol Endocri... - July 17, 2020 Category: Endocrinology Authors: Gauzzi MC, Fantuzzi L Tags: Am J Physiol Endocrinol Metab Source Type: research

Lowering oxidative stress in ghrelin cells stimulates ghrelin secretion.
Abstract Ghrelin is a predominantly stomach-derived peptide hormone with many actions including regulation of food intake, body weight, and blood glucose. Plasma ghrelin levels are robustly regulated by feeding status, with its levels increasing upon caloric restriction and decreasing after food intake. At least some of this regulation might be due to direct responsiveness of ghrelin cells to changes in circulating nutrients, including glucose. Indeed, oral and parental glucose administration to humans and mice lower plasma ghrelin. Also dissociated mouse gastric mucosal cell preparations, which contain ghrelin ce...
Source: Am J Physiol Endocri... - June 15, 2020 Category: Endocrinology Authors: Mani BK, Osborne-Lawrence S, Metzger N, Zigman JM Tags: Am J Physiol Endocrinol Metab Source Type: research

Acute insulin deprivation results in altered mitochondrial substrate sensitivity conducive to greater fatty acid transport.
Abstract Type 1 and type 2 diabetes are both tightly associated with impaired glucose control. While both pathologies stem from different mechanisms, a reduction in insulin action coincides with drastic metabolic dysfunction in skeletal muscle and metabolic inflexibility. However, the underlying explanation for this response remains poorly understood, particularly since it is difficult to distinguish the role of attenuated insulin action from the detrimental effects of reactive lipid accumulation which impair mitochondrial function and promote reactive oxygen species (ROS) emission. We therefore utilized streptozo...
Source: Am J Physiol Endocri... - June 15, 2020 Category: Endocrinology Authors: Miotto PM, Petrick HL, Holloway GP Tags: Am J Physiol Endocrinol Metab Source Type: research

Oligomeric collagen as an encapsulation material for islet/ β cell replacement: Effect of islet source, dose, implant site, and administration format.
Oligomeric collagen as an encapsulation material for islet/β cell replacement: Effect of islet source, dose, implant site, and administration format. Am J Physiol Endocrinol Metab. 2020 Jun 16;: Authors: Stephens CH, Morrison RA, McLaughlin M, Orr K, Tersey SA, Scott-Moncrieff JC, Mirmira RG, Considine RV, Voytik-Harbin S Abstract Replacement of islets/β cells that provide long-lasting glucose-sensing and insulin-releasing functions has the potential to restore extended glycemic control in individuals with type 1 diabetes. Unfortunately, persistent challenges preclude such therapies from wid...
Source: Am J Physiol Endocri... - June 15, 2020 Category: Endocrinology Authors: Stephens CH, Morrison RA, McLaughlin M, Orr K, Tersey SA, Scott-Moncrieff JC, Mirmira RG, Considine RV, Voytik-Harbin S Tags: Am J Physiol Endocrinol Metab Source Type: research

Long-term high-fat feeding exacerbates short-term increases in adipose mitochondrial reactive oxygen species, without impairing mitochondrial respiration.
Abstract White adipose tissue (WAT) dysfunction in obesity is implicated in the onset of whole-body insulin resistance. Alterations in mitochondrial bioenergetics, namely impaired mitochondrial respiration and increased mitochondrial reactive oxygen species (mtROS) production, have been suggested to contribute to this metabolic dysregulation. However, techniques investigating mitochondrial function are classically normalized to tissue weight, which may be confounding when considering obesity-related adipocyte hypertrophy. Furthermore, the effect of long-term high-fat diet (HFD) on mtROS in WAT has yet to be elucid...
Source: Am J Physiol Endocri... - June 15, 2020 Category: Endocrinology Authors: Politis-Barber V, Brunetta HS, Paglialunga S, Petrick HL, Holloway GP Tags: Am J Physiol Endocrinol Metab Source Type: research

Circulating extracellular vesicles from patients with valvular heart disease induce neutrophil chemotaxis via FOXO3a and the inhibiting role of dexmedetomidine.
Abstract We previously demonstrated that circulating extracellular vesicles(EVs) from patients with valvular heart disease(VHD, vEVs) contain inflammatory components and inhibit endothelium-dependent vasodilation. Neutrophil chemotaxis plays a key role in renal dysfunction, and dexmedetomidine (DEX) can reduce renal dysfunction in cardiac surgery. However, roles of vEVs in neutrophil chemotaxis, and effects of DEX on vEVs are unknown. Here, we investigated the impact of vEVs on neutrophil chemotaxis in kidneys and the influence of DEX on vEVs. Circulating EVs were isolated from healthy subjects and patients with V...
Source: Am J Physiol Endocri... - June 8, 2020 Category: Endocrinology Authors: Yuan HX, Chen CY, Li YQ, Ning DS, Li Y, Chen YT, Li SX, Fu MX, Li XD, Ma J, Jian YP, Liu DH, Mo ZW, Peng YM, Xu KQ, Ou ZJ, Ou JS Tags: Am J Physiol Endocrinol Metab Source Type: research

Fecal microbiota transplantation from high caloric-fed donors alters glucose metabolism in recipient mice, independently of adiposity or exercise status.
Abstract Studies suggest gut microbiota contributes to the development of obesity and the metabolic syndrome. Exercise alters microbiota composition and diversity and is protective of these maladies. We tested whether the protective metabolic effects of exercise are mediated through fecal components through assessment of body composition and metabolism in recipients of fecal microbiota transplantation (FMT) from exercise-trained (ET) mice fed normal or high energy diets. Donor C57BL/6J mice were fed a chow or high fat, high sucrose (HFHS) diet for 4wk to induce obesity and glucose intolerance. Mice were divided in...
Source: Am J Physiol Endocri... - June 8, 2020 Category: Endocrinology Authors: Zoll J, Read MR, Heywood SE, Estevez E, Marshall JP, Kammoun HL, Allen TL, Holmes AJ, Febbraio MA, Henstridge DC Tags: Am J Physiol Endocrinol Metab Source Type: research

NOD2 in hepatocytes engages a liver-gut axis to protect against steatosis, fibrosis, and gut dysbiosis during fatty liver disease in mice.
Abstract Obesity promotes non-alcoholic fatty liver disease (NAFLD). The intestinal microbiota contributes to NAFLD progression through a gut to liver pathway that promotes inflammation and fibrosis. Gut microbiota-derived factors can travel to the liver and activate immune responses in liver-resident cells to promote inflammation and NAFLD. Little is known about bacterial sensors or immune responses that can protect against NAFLD. We tested if the bacterial cell wall sensor nucleotide-binding oligomerization domain-containing (NOD)2 protects against diet-induced NAFLD in mice. Whole-body deletion of NOD2 exacerba...
Source: Am J Physiol Endocri... - June 8, 2020 Category: Endocrinology Authors: Cavallari JF, Pokrajac NT, Zlitni S, Foley KP, Henriksbo BD, Schertzer JD Tags: Am J Physiol Endocrinol Metab Source Type: research

Adipose tissue macrophage burden, systemic inflammation and insulin resistance.
Abstract Adipose tissue inflammation, as defined by macrophage accumulation, is proposed to cause insulin resistance and systemic inflammation. Because the strength of this relationship for humans is unclear, we tested whether adipose tissue macrophage (ATM) burden is correlated with these health indicators. Using immunohistochemistry we measured abdominal subcutaneous CD68+ (total ATM) , CD14+ (pro-inflammatory/M1), and CD206+ (anti-inflammatory/M2) ATM in 97 volunteers BMI 20 - 38 kg/m2, in addition to body composition, adipocyte size, HOMA-IR, ADIPOpalmitate-IR, plasma lipids, TNF and IL-6 concentrations. There...
Source: Am J Physiol Endocri... - June 1, 2020 Category: Endocrinology Authors: Jia Q, Morgan-Bathke ME, Jensen MD Tags: Am J Physiol Endocrinol Metab Source Type: research

Reply to Jakovac: About COVID-19 and vitamin D.
PMID: 32432923 [PubMed - as supplied by publisher] (Source: Am J Physiol Endocri...)
Source: Am J Physiol Endocri... - May 21, 2020 Category: Endocrinology Authors: Facchiano A, Facchiano A, Bartoli M, Ricci A, Facchiano F Tags: Am J Physiol Endocrinol Metab Source Type: research

Glycemic control of type 2 diabetic patients with coronavirus disease during hospitalization: a proposal for early insulin therapy.
PMID: 32401039 [PubMed - as supplied by publisher] (Source: Am J Physiol Endocri...)
Source: Am J Physiol Endocri... - May 14, 2020 Category: Endocrinology Authors: Nakhleh A, Shehadeh N Tags: Am J Physiol Endocrinol Metab Source Type: research

Am J Physiol Endocrinol Metab; +33 new citations
33 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Endocrinol Metab These pubmed results were generated on 2020/05/07PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. (Source: Am J Physiol Endocri...)
Source: Am J Physiol Endocri... - May 7, 2020 Category: Endocrinology Tags: Report Source Type: research

Biological plausibility for interactions between dietary fat, resveratrol, ACE2 and SARS-CoV illness severity.
Abstract The ACE2 cellular receptor is responsible for the pathogenesis of SARS-CoV, thus impacting the entrance and clearance of the virus. Studies demonstrate that upregulation of ACE2 has a protective effect on SARS-CoV-2 illness severity. Moreover, animal studies demonstrate that dietary intake can modulate ACE2 gene expression and function. A high intake of resveratrol may have a protective role, upregulating ACE2, whereas a high intake of dietary fat may have a detrimental role, downregulating ACE2. As such, we postulate on the biological plausibility of interactions between dietary fat and/or resveratrol an...
Source: Am J Physiol Endocri... - April 19, 2020 Category: Endocrinology Authors: Horne JR, Vohl MC Tags: Am J Physiol Endocrinol Metab Source Type: research

Am J Physiol Endocrinol Metab; +23 new citations
23 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Endocrinol Metab These pubmed results were generated on 2020/04/14PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. (Source: Am J Physiol Endocri...)
Source: Am J Physiol Endocri... - April 14, 2020 Category: Endocrinology Tags: Report Source Type: research

Alanine, arginine, cysteine, and proline but not glutamine are substrates for and acute mediators of the liver-alpha cell axis in female mice.
CONCLUSION: Our data suggest that alanine, arginine, cysteine, and proline but not glutamine are involved in the acute regulation of the liver-alpha cell axis in female mice as they all increased glucagon secretion and their disappearance rate was altered by GRA. PMID: 32255678 [PubMed - as supplied by publisher] (Source: Am J Physiol Endocri...)
Source: Am J Physiol Endocri... - April 6, 2020 Category: Endocrinology Authors: Galsgaard KD, Jepsen SL, Kjeldsen SAS, Pedersen J, Wewer Albrechtsen NJ, Holst JJ Tags: Am J Physiol Endocrinol Metab Source Type: research

Utilization of biomarkers as predictors of skeletal muscle mitochondrial content after physiological intervention and in clinical settings.
Abstract The measurement of mitochondrial content is essential for bioenergetic research as it provides a tool to evaluate if changes in mitochondrial function are strictly due to changes in content or other mechanisms that influence function. In this perspective, we argue that commonly used biomarkers of mitochondrial content may possess limited utility for capturing changes in content with physiological intervention. Moreover, we argue that they may not provide reliable estimates of content in certain pathological situations. Finally, we discuss potential solutions to overcome issues related to the utilization o...
Source: Am J Physiol Endocri... - April 6, 2020 Category: Endocrinology Authors: Groennebaek T, Nielsen J, Jespersen NR, Botker HE, de Paoli FV, Miller BF, Vissing K Tags: Am J Physiol Endocrinol Metab Source Type: research

The inducible β5i proteasome subunit contributes to proinsulin degradation in GRP94 deficient β cells and is overexpressed in type 2 diabetes pancreatic islets.
The inducible β5i proteasome subunit contributes to proinsulin degradation in GRP94 deficient β cells and is overexpressed in type 2 diabetes pancreatic islets. Am J Physiol Endocrinol Metab. 2020 Apr 07;: Authors: Khilji MS, Bresson SE, Verstappen D, Pihl C, Andersen PAK, Agergaard JB, Dahlby T, Holgersen Bryde T, Klindt K, Nielsen CK, Walentinsson A, Zivkovic D, Bousquet MP, Tyrberg B, Richardson SJ, Morgan NG, Mandrup-Poulsen T, Marzec MT Abstract Proinsulin is a misfolding-prone protein and its efficient breakdown is critical, when b-cells are confronted with high insulin biosynthetic de...
Source: Am J Physiol Endocri... - April 6, 2020 Category: Endocrinology Authors: Khilji MS, Bresson SE, Verstappen D, Pihl C, Andersen PAK, Agergaard JB, Dahlby T, Holgersen Bryde T, Klindt K, Nielsen CK, Walentinsson A, Zivkovic D, Bousquet MP, Tyrberg B, Richardson SJ, Morgan NG, Mandrup-Poulsen T, Marzec MT Tags: Am J Physiol Endocrinol Metab Source Type: research

Comparative label-free mass spectrometric analysis of temporal changes in the skeletal muscle proteome after impact trauma in rats.
This study aimed to characterize changes in the muscle proteome during the destruction, repair and early remodeling phases after impact trauma in male Wistar rats. Muscle tissue was collected from uninjured control rats and rats that were euthanized between 6 h to 14 d after impact injury. Muscle tissue was analyzed using unbiased, data-independent acquisition LC-MS/MS. We identified 770 reviewed proteins in the muscle tissue, 296 of which were differentially abundant between the control and injury groups (P£0.05). Around 50 proteins showed large differences (³10-fold) or a distinct pattern of abundance after in...
Source: Am J Physiol Endocri... - April 6, 2020 Category: Endocrinology Authors: Liu L, Broszczak DA, Broadbent JA, Singh DP, Steck R, Parker TJ, Peake JM Tags: Am J Physiol Endocrinol Metab Source Type: research

Am J Physiol Endocrinol Metab; +18 new citations
18 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Endocrinol Metab These pubmed results were generated on 2020/04/01PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. (Source: Am J Physiol Endocri...)
Source: Am J Physiol Endocri... - April 1, 2020 Category: Endocrinology Tags: Report Source Type: research

Am J Physiol Endocrinol Metab; +26 new citations
26 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Endocrinol Metab These pubmed results were generated on 2020/03/25PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. (Source: Am J Physiol Endocri...)
Source: Am J Physiol Endocri... - March 25, 2020 Category: Endocrinology Tags: Report Source Type: research

The effect of acute dual SGLT1/SGLT2 inhibition on incretin release and glucose metabolism after gastric bypass surgery.
bad S Abstract Enhanced meal-related enteroendocrine secretion, particularly of glucagon-like peptide-1 (GLP-1), contributes to weight-loss and improved glycemia after Roux-en-Y gastric bypass (RYGB). Dietary glucose drives GLP-1 and glucose-dependent insulinotropic polypeptide (GIP) secretion postoperatively. Understanding how glucose triggers incretin secretion following RYGB could lead to new treatments of diabetes and obesity. In vitro, incretin release depends on glucose absorption via sodium-glucose cotransporter-1 (SGLT1). We investigated the importance of SGLT1/SGLT2 for enteropancreatic hormone concentrat...
Source: Am J Physiol Endocri... - March 16, 2020 Category: Endocrinology Authors: Martinussen C, Veedfald S, Dirksen C, Bojsen-Møller KN, Svane MS, Wewer Albrechtsen NJ, van Hall G, Kristiansen VB, Fenger M, Holst JJ, Madsbad S Tags: Am J Physiol Endocrinol Metab Source Type: research

Irisin counteracts high glucose and fatty acid induced cytotoxicity by preserving AMPK-insulin receptor signaling axis in C2C12 myoblast.
In this study, we determine the effect of irisin on high glucose and fatty acid induced damages using irisin overexpressed mouse C2C12 myoblast (Irisin-C2C12) and skeletal muscle from irisin-injected mice. As compared to empty vector transfected control, irisin overexpression resulted in a marked increase of cell viability and decrease of apoptosis under high glucose stress. Progression of cell cycle into G2/M phase under proliferative condition was observed by irisin overexpression. Furthermore, glucose uptake, glycogen accumulation and phosphorylation of AMPKα / insulin receptor β subunit (IRβ) / Erk1/2 i...
Source: Am J Physiol Endocri... - March 16, 2020 Category: Endocrinology Authors: Yano N, Zhang L, Wei D, Dubielecka PM, Wei L, Zhuang S, Zhu P, Qin G, Liu PY, Chin YE, Zhao TC Tags: Am J Physiol Endocrinol Metab Source Type: research

Androgen aggravates liver fibrosis by activation of NLRP3 inflammasome in CCl4 induced liver injury mouse model.
In this study, we first investigated the differences of liver injury between male and female mice, using the CCl4 induced liver injury mouse model. It showed that the liver damage of male mice was much more severe than that of female mice. Both the acute injury and fibrosis of the liver were reduced when androgens were depleted by castration of male mice. The vulnerability of male liver was associated with testis endocrine and excessive activation of inflammatory response in the liver. Castrated male mice with testosterone supplementation showed aggravated liver inflammatory response and fibrosis. The activity of NOD-like ...
Source: Am J Physiol Endocri... - March 16, 2020 Category: Endocrinology Authors: Ma X, Zhou Y, Qiao B, Jiang S, Shen Q, Han Y, Liu A, Chen X, Wei L, Zhou L, Zhao J Tags: Am J Physiol Endocrinol Metab Source Type: research

Corrigendum.
Authors: PMID: 32150463 [PubMed - in process] (Source: Am J Physiol Endocri...)
Source: Am J Physiol Endocri... - February 29, 2020 Category: Endocrinology Tags: Am J Physiol Endocrinol Metab Source Type: research

Effects of intrauterine insulin-like growth factor-1 therapy for fetal growth restriction on adult metabolism and body composition are sex-specific.
Abstract Fetal growth restriction (FGR) is associated with compromised growth and metabolic function throughout life. Intrauterine therapy of FGR with intra-amniotic insulin-like growth factor-1 (IGF1) enhances fetal growth and alters perinatal metabolism and growth in a sex-specific manner, but the adult effects are unknown. We investigated the effects of intra-amniotic IGF1 treatment of FGR on adult growth and body composition, adrenergic sensitivity, and glucose-insulin axis regulation. Placental embolisation-induced FGR was treated with 4 weekly doses of 360 µg intra-amniotic IGF1 (FGRI) or saline (FGRS)...
Source: Am J Physiol Endocri... - February 25, 2020 Category: Endocrinology Authors: Spiroski AM, Oliver MH, Jaquiery AL, Gunn TD, Harding JE, Bloomfield FH Tags: Am J Physiol Endocrinol Metab Source Type: research

Postbiotics for NOD2 require non-hematopoietic RIPK2 to improve blood glucose and metabolic inflammation in mice.
r JD Abstract Defining the host receptors and metabolic consequences of bacterial components can help explain how the microbiome influences metabolic diseases. Bacterial peptidoglycans that activate nucleotide-binding oligomerization domain-containing (NOD)1 worsen glucose control, whereas NOD2 activation improves glycemia. Receptor-interacting serine/threonine-protein kinase 2 (RIPK2) is required for innate immunity instigated by NOD1 and NOD2. The role of RIPK2 in the divergent effects of NOD1 versus NOD2 on blood glucose was unknown. We found that whole body deletion of RIPK2 negated all effects of NOD1 or NOD2...
Source: Am J Physiol Endocri... - February 25, 2020 Category: Endocrinology Authors: Cavallari JF, Barra NG, Foley KP, Lee A, Duggan BM, Henriksbo BD, Anhê FF, Ashkar AA, Schertzer JD Tags: Am J Physiol Endocrinol Metab Source Type: research