Monocyte immunometabolic reprogramming in human pregnancy: contribution of trophoblast cells
Am J Physiol Endocrinol Metab. 2023 Dec 20. doi: 10.1152/ajpendo.00357.2023. Online ahead of print.ABSTRACTImmunometabolism research is uncovering the relationship between metabolic features and immune cell functions in physiological and pathological conditions. Normal pregnancy entails a fine immune and metabolic regulation of the maternal-fetal interaction to assist the energetic demands of the fetus with immune homeostasis maintenance. Here, we determined the immunometabolic status of monocytes of pregnant women compared to non-pregnant controls and its impact on monocyte antiinflammatory functions such as efferocytosis...
Source: Am J Physiol Endocri... - December 20, 2023 Category: Endocrinology Authors: F átima Merech Soledad Gori Guillermina Calo Vanesa Hauk Daniel Paparini Daiana Rios Brenda Lara Luciana Doga Luciana D'Eramo Aldo Squassi Rossana Ramhorst Rafael J Arg üello Claudia P érez Leirós Daiana Vota Source Type: research
Reversible expansion of tissue macrophages in response to macrophage colony-stimulating factor (CSF1) transforms systemic lipid and carbohydrate metabolism
CONCLUSION: These results demonstrate the existence of a dynamic equilibrium between CSF1, the mononuclear phagocyte system and control of liver:body weight ratio, which in turn controls systemic metabolic homeostasis. This novel macrophage regulatory axis has the potential to promote fat mobilisation, without changes in appetence, which may have novel implications for managing metabolic syndrome.PMID:38117267 | DOI:10.1152/ajpendo.00347.2023 (Source: Am J Physiol Endocri...)
Source: Am J Physiol Endocri... - December 20, 2023 Category: Endocrinology Authors: Sahar Keshvari Jesse J R Masson Michelle Ferrari-Cestari Liviu-Gabriel Bodea Fathima Nooru-Mohamed Brian W C Tse Kamil A Sokolowski Lena Batoon Omkar L Patkar Mitchell A Sullivan Hilmar Ebersbach Cian Stutz Robert G Parton Kim M Summers Allison R Pettit D Source Type: research
Vertical sleeve gastrectomy improves glucose-insulin homeostasis by enhancing beta cell function and survival via FGF15/19
Am J Physiol Endocrinol Metab. 2023 Dec 20. doi: 10.1152/ajpendo.00218.2023. Online ahead of print.ABSTRACTVertical sleeve gastrectomy (VSG) restores glucose homeostasis in obese mice and humans. In addition, the increased fibroblast growth factor (FGF)15/19 circulating level post-surgery has been implicated in this effect. However, the impact of FGF15/19 on pancreatic islets remains unclear. Using a diet-induced obese mice model, we demonstrate that VSG attenuates insulin hypersecretion in isolated pancreatic islets, likely due to morphological alterations in the endocrine pancreas such as reduction in islet, beta cell, a...
Source: Am J Physiol Endocri... - December 20, 2023 Category: Endocrinology Authors: Gabriela M Soares Sandra L Balbo Gabriela A Bronczek Jean F Vettorazzi Carine Marmentini Lucas Zangerolamo Licio A Velloso Everardo M Carneiro Source Type: research
Monocyte immunometabolic reprogramming in human pregnancy: contribution of trophoblast cells
Am J Physiol Endocrinol Metab. 2023 Dec 20. doi: 10.1152/ajpendo.00357.2023. Online ahead of print.ABSTRACTImmunometabolism research is uncovering the relationship between metabolic features and immune cell functions in physiological and pathological conditions. Normal pregnancy entails a fine immune and metabolic regulation of the maternal-fetal interaction to assist the energetic demands of the fetus with immune homeostasis maintenance. Here, we determined the immunometabolic status of monocytes of pregnant women compared to non-pregnant controls and its impact on monocyte antiinflammatory functions such as efferocytosis...
Source: Am J Physiol Endocri... - December 20, 2023 Category: Endocrinology Authors: F átima Merech Soledad Gori Guillermina Calo Vanesa Hauk Daniel Paparini Daiana Rios Brenda Lara Luciana Doga Luciana D'Eramo Aldo Squassi Rossana Ramhorst Rafael J Arg üello Claudia P érez Leirós Daiana Vota Source Type: research
Reversible expansion of tissue macrophages in response to macrophage colony-stimulating factor (CSF1) transforms systemic lipid and carbohydrate metabolism
CONCLUSION: These results demonstrate the existence of a dynamic equilibrium between CSF1, the mononuclear phagocyte system and control of liver:body weight ratio, which in turn controls systemic metabolic homeostasis. This novel macrophage regulatory axis has the potential to promote fat mobilisation, without changes in appetence, which may have novel implications for managing metabolic syndrome.PMID:38117267 | DOI:10.1152/ajpendo.00347.2023 (Source: Am J Physiol Endocri...)
Source: Am J Physiol Endocri... - December 20, 2023 Category: Endocrinology Authors: Sahar Keshvari Jesse J R Masson Michelle Ferrari-Cestari Liviu-Gabriel Bodea Fathima Nooru-Mohamed Brian W C Tse Kamil A Sokolowski Lena Batoon Omkar L Patkar Mitchell A Sullivan Hilmar Ebersbach Cian Stutz Robert G Parton Kim M Summers Allison R Pettit D Source Type: research
Vertical sleeve gastrectomy improves glucose-insulin homeostasis by enhancing beta cell function and survival via FGF15/19
Am J Physiol Endocrinol Metab. 2023 Dec 20. doi: 10.1152/ajpendo.00218.2023. Online ahead of print.ABSTRACTVertical sleeve gastrectomy (VSG) restores glucose homeostasis in obese mice and humans. In addition, the increased fibroblast growth factor (FGF)15/19 circulating level post-surgery has been implicated in this effect. However, the impact of FGF15/19 on pancreatic islets remains unclear. Using a diet-induced obese mice model, we demonstrate that VSG attenuates insulin hypersecretion in isolated pancreatic islets, likely due to morphological alterations in the endocrine pancreas such as reduction in islet, beta cell, a...
Source: Am J Physiol Endocri... - December 20, 2023 Category: Endocrinology Authors: Gabriela M Soares Sandra L Balbo Gabriela A Bronczek Jean F Vettorazzi Carine Marmentini Lucas Zangerolamo Licio A Velloso Everardo M Carneiro Source Type: research
Monocyte immunometabolic reprogramming in human pregnancy: contribution of trophoblast cells
Am J Physiol Endocrinol Metab. 2023 Dec 20. doi: 10.1152/ajpendo.00357.2023. Online ahead of print.ABSTRACTImmunometabolism research is uncovering the relationship between metabolic features and immune cell functions in physiological and pathological conditions. Normal pregnancy entails a fine immune and metabolic regulation of the maternal-fetal interaction to assist the energetic demands of the fetus with immune homeostasis maintenance. Here, we determined the immunometabolic status of monocytes of pregnant women compared to non-pregnant controls and its impact on monocyte antiinflammatory functions such as efferocytosis...
Source: Am J Physiol Endocri... - December 20, 2023 Category: Endocrinology Authors: F átima Merech Soledad Gori Guillermina Calo Vanesa Hauk Daniel Paparini Daiana Rios Brenda Lara Luciana Doga Luciana D'Eramo Aldo Squassi Rossana Ramhorst Rafael J Arg üello Claudia P érez Leirós Daiana Vota Source Type: research
Reversible expansion of tissue macrophages in response to macrophage colony-stimulating factor (CSF1) transforms systemic lipid and carbohydrate metabolism
CONCLUSION: These results demonstrate the existence of a dynamic equilibrium between CSF1, the mononuclear phagocyte system and control of liver:body weight ratio, which in turn controls systemic metabolic homeostasis. This novel macrophage regulatory axis has the potential to promote fat mobilisation, without changes in appetence, which may have novel implications for managing metabolic syndrome.PMID:38117267 | DOI:10.1152/ajpendo.00347.2023 (Source: Am J Physiol Endocri...)
Source: Am J Physiol Endocri... - December 20, 2023 Category: Endocrinology Authors: Sahar Keshvari Jesse J R Masson Michelle Ferrari-Cestari Liviu-Gabriel Bodea Fathima Nooru-Mohamed Brian W C Tse Kamil A Sokolowski Lena Batoon Omkar L Patkar Mitchell A Sullivan Hilmar Ebersbach Cian Stutz Robert G Parton Kim M Summers Allison R Pettit D Source Type: research
Vertical sleeve gastrectomy improves glucose-insulin homeostasis by enhancing beta cell function and survival via FGF15/19
Am J Physiol Endocrinol Metab. 2023 Dec 20. doi: 10.1152/ajpendo.00218.2023. Online ahead of print.ABSTRACTVertical sleeve gastrectomy (VSG) restores glucose homeostasis in obese mice and humans. In addition, the increased fibroblast growth factor (FGF)15/19 circulating level post-surgery has been implicated in this effect. However, the impact of FGF15/19 on pancreatic islets remains unclear. Using a diet-induced obese mice model, we demonstrate that VSG attenuates insulin hypersecretion in isolated pancreatic islets, likely due to morphological alterations in the endocrine pancreas such as reduction in islet, beta cell, a...
Source: Am J Physiol Endocri... - December 20, 2023 Category: Endocrinology Authors: Gabriela M Soares Sandra L Balbo Gabriela A Bronczek Jean F Vettorazzi Carine Marmentini Lucas Zangerolamo Licio A Velloso Everardo M Carneiro Source Type: research
Monocyte immunometabolic reprogramming in human pregnancy: contribution of trophoblast cells
Am J Physiol Endocrinol Metab. 2023 Dec 20. doi: 10.1152/ajpendo.00357.2023. Online ahead of print.ABSTRACTImmunometabolism research is uncovering the relationship between metabolic features and immune cell functions in physiological and pathological conditions. Normal pregnancy entails a fine immune and metabolic regulation of the maternal-fetal interaction to assist the energetic demands of the fetus with immune homeostasis maintenance. Here, we determined the immunometabolic status of monocytes of pregnant women compared to non-pregnant controls and its impact on monocyte antiinflammatory functions such as efferocytosis...
Source: Am J Physiol Endocri... - December 20, 2023 Category: Endocrinology Authors: F átima Merech Soledad Gori Guillermina Calo Vanesa Hauk Daniel Paparini Daiana Rios Brenda Lara Luciana Doga Luciana D'Eramo Aldo Squassi Rossana Ramhorst Rafael J Arg üello Claudia P érez Leirós Daiana Vota Source Type: research
Reversible expansion of tissue macrophages in response to macrophage colony-stimulating factor (CSF1) transforms systemic lipid and carbohydrate metabolism
CONCLUSION: These results demonstrate the existence of a dynamic equilibrium between CSF1, the mononuclear phagocyte system and control of liver:body weight ratio, which in turn controls systemic metabolic homeostasis. This novel macrophage regulatory axis has the potential to promote fat mobilisation, without changes in appetence, which may have novel implications for managing metabolic syndrome.PMID:38117267 | DOI:10.1152/ajpendo.00347.2023 (Source: Am J Physiol Endocri...)
Source: Am J Physiol Endocri... - December 20, 2023 Category: Endocrinology Authors: Sahar Keshvari Jesse J R Masson Michelle Ferrari-Cestari Liviu-Gabriel Bodea Fathima Nooru-Mohamed Brian W C Tse Kamil A Sokolowski Lena Batoon Omkar L Patkar Mitchell A Sullivan Hilmar Ebersbach Cian Stutz Robert G Parton Kim M Summers Allison R Pettit D Source Type: research
Vertical sleeve gastrectomy improves glucose-insulin homeostasis by enhancing beta cell function and survival via FGF15/19
Am J Physiol Endocrinol Metab. 2023 Dec 20. doi: 10.1152/ajpendo.00218.2023. Online ahead of print.ABSTRACTVertical sleeve gastrectomy (VSG) restores glucose homeostasis in obese mice and humans. In addition, the increased fibroblast growth factor (FGF)15/19 circulating level post-surgery has been implicated in this effect. However, the impact of FGF15/19 on pancreatic islets remains unclear. Using a diet-induced obese mice model, we demonstrate that VSG attenuates insulin hypersecretion in isolated pancreatic islets, likely due to morphological alterations in the endocrine pancreas such as reduction in islet, beta cell, a...
Source: Am J Physiol Endocri... - December 20, 2023 Category: Endocrinology Authors: Gabriela M Soares Sandra L Balbo Gabriela A Bronczek Jean F Vettorazzi Carine Marmentini Lucas Zangerolamo Licio A Velloso Everardo M Carneiro Source Type: research
Monocyte immunometabolic reprogramming in human pregnancy: contribution of trophoblast cells
Am J Physiol Endocrinol Metab. 2023 Dec 20. doi: 10.1152/ajpendo.00357.2023. Online ahead of print.ABSTRACTImmunometabolism research is uncovering the relationship between metabolic features and immune cell functions in physiological and pathological conditions. Normal pregnancy entails a fine immune and metabolic regulation of the maternal-fetal interaction to assist the energetic demands of the fetus with immune homeostasis maintenance. Here, we determined the immunometabolic status of monocytes of pregnant women compared to non-pregnant controls and its impact on monocyte antiinflammatory functions such as efferocytosis...
Source: Am J Physiol Endocri... - December 20, 2023 Category: Endocrinology Authors: F átima Merech Soledad Gori Guillermina Calo Vanesa Hauk Daniel Paparini Daiana Rios Brenda Lara Luciana Doga Luciana D'Eramo Aldo Squassi Rossana Ramhorst Rafael J Arg üello Claudia P érez Leirós Daiana Vota Source Type: research
Reversible expansion of tissue macrophages in response to macrophage colony-stimulating factor (CSF1) transforms systemic lipid and carbohydrate metabolism
CONCLUSION: These results demonstrate the existence of a dynamic equilibrium between CSF1, the mononuclear phagocyte system and control of liver:body weight ratio, which in turn controls systemic metabolic homeostasis. This novel macrophage regulatory axis has the potential to promote fat mobilisation, without changes in appetence, which may have novel implications for managing metabolic syndrome.PMID:38117267 | DOI:10.1152/ajpendo.00347.2023 (Source: Am J Physiol Endocri...)
Source: Am J Physiol Endocri... - December 20, 2023 Category: Endocrinology Authors: Sahar Keshvari Jesse J R Masson Michelle Ferrari-Cestari Liviu-Gabriel Bodea Fathima Nooru-Mohamed Brian W C Tse Kamil A Sokolowski Lena Batoon Omkar L Patkar Mitchell A Sullivan Hilmar Ebersbach Cian Stutz Robert G Parton Kim M Summers Allison R Pettit D Source Type: research
Vertical sleeve gastrectomy improves glucose-insulin homeostasis by enhancing beta cell function and survival via FGF15/19
Am J Physiol Endocrinol Metab. 2023 Dec 20. doi: 10.1152/ajpendo.00218.2023. Online ahead of print.ABSTRACTVertical sleeve gastrectomy (VSG) restores glucose homeostasis in obese mice and humans. In addition, the increased fibroblast growth factor (FGF)15/19 circulating level post-surgery has been implicated in this effect. However, the impact of FGF15/19 on pancreatic islets remains unclear. Using a diet-induced obese mice model, we demonstrate that VSG attenuates insulin hypersecretion in isolated pancreatic islets, likely due to morphological alterations in the endocrine pancreas such as reduction in islet, beta cell, a...
Source: Am J Physiol Endocri... - December 20, 2023 Category: Endocrinology Authors: Gabriela M Soares Sandra L Balbo Gabriela A Bronczek Jean F Vettorazzi Carine Marmentini Lucas Zangerolamo Licio A Velloso Everardo M Carneiro Source Type: research
