Genetics and diet shape the relationship between islet function and whole-body metabolism
Am J Physiol Endocrinol Metab. 2024 Apr 3. doi: 10.1152/ajpendo.00060.2024. Online ahead of print.ABSTRACTDespite the fact that genes and the environment are known to play a central role in islet function, our knowledge of how these parameters interact to modulate insulin secretory function remains relatively poor. Presently, we performed ex vivo glucose-stimulated insulin secretion and insulin content assays in islets of 213 mice from 13 inbred mouse strains on chow, western diet, and ketogenic diet. Strikingly, among these 13 strains, islets from the commonly used C57BL/6J mouse strain were the least glucose responsive. ...
Source: Am J Physiol Endocri... - April 3, 2024 Category: Endocrinology Authors: Belinda Yau S øren Madsen Marin E Healy Kristen C Cooke Andreas M Fritzen Ida H Thorius Jacqueline St öckli David E James Melkam A Kebede Source Type: research
Glycogen synthesis is required for adaptive thermogenesis in beige adipose tissue and affects diet-induced obesity
In conclusion, our results underscore the pivotal role of glycogen synthesis in adaptive thermogenesis in beige adipose tissue and its impact on diet-induced obesity in mice.PMID:38568151 | DOI:10.1152/ajpendo.00074.2024 (Source: Am J Physiol Endocri...)
Source: Am J Physiol Endocri... - April 3, 2024 Category: Endocrinology Authors: Shixuan Zhuo Meijuan Bai Zinan Wang Lingling Chen Zixuan Li Jinzhu Chen Xiaoyi Ye Cheng Guo Yan Chen Source Type: research
A bout of aerobic exercise in the heat increases carbohydrate use but does not enhance the disposal of an oral glucose load, in healthy active individuals
Am J Physiol Endocrinol Metab. 2024 Apr 3. doi: 10.1152/ajpendo.00312.2023. Online ahead of print.ABSTRACTWe investigated if a bout of exercise in a hot environment (HEAT) would reduce the postprandial hyperglycemia induced by glucose ingestion. The hypothesis was that HEAT stimulating glycogen use would increase the disposal of the ingested glucose (i.e., OGTT; 75 g of glucose). Separated by at least 1 week, nine young-healthy individuals underwent three trials after an overnight fast in a randomized order. Two trials included 50 min of pedaling at 58±5% VO2MAX either in a thermoneutral (21±1ºC; NEUTRAL) or in a hot en...
Source: Am J Physiol Endocri... - April 3, 2024 Category: Endocrinology Authors: Ricardo Mora-Rodriguez Alfonso Moreno-Caba ñas Laura Álvarez-Jimenez Diego Mora-Gonzalez Juan Fernando Ortega Felix Morales-Palomo Source Type: research
SMEK1 ablation promotes glucose uptake and improves obesity-related metabolic dysfunction via AMPK signaling pathway
CONCLUSION: Our findings reveal a novel role of SMEK1 in obesity and glucose homeostasis, providing a potential new therapeutic target for obesity and metabolic dysfunction.PMID:38568153 | DOI:10.1152/ajpendo.00387.2023 (Source: Am J Physiol Endocri...)
Source: Am J Physiol Endocri... - April 3, 2024 Category: Endocrinology Authors: Shijun Wei Yu Song Zhengbin Li Ai Liu Yunfang Xie Shang Gao Hongbiao Shi Ping Sun Zekun Wang Yecheng Jin Wenjie Sun Xi Li Jiangxia Li Qiji Liu Source Type: research
Effects of Follicle Stimulating Hormone on Energy Balance and Tissue Metabolic Health After Loss of Ovarian Function
Am J Physiol Endocrinol Metab. 2024 Mar 27. doi: 10.1152/ajpendo.00400.2023. Online ahead of print.ABSTRACTLoss of ovarian function imparts increased susceptibility to obesity and metabolic disease. These effects are largely attributed to decreased estradiol (E2), but the role of increased follicle stimulating hormone (FSH) in modulating energy balance has not been fully investigated. Previous work that blocked FSH binding to its receptor in mice suggested this hormone may play a part in modulating body weight and energy expenditure after ovariectomy. We used an alternate approach to isolate the individual and combined con...
Source: Am J Physiol Endocri... - March 27, 2024 Category: Endocrinology Authors: Andrew E Libby Claudia Solt Matthew Jackman Vanessa Sherk Rebecca M Foright Ginger C Johnson Thi-Tina Nguyen Matthew Breit Nicholas Hulett Michael Rudolph Paul A Roberson Elizabeth Wellberg Purevsuren Jambal Rebecca L Scalzo Janine Higgins T Rajendra Kuma Source Type: research
Impaired muscle oxygenation despite normal pulmonary function in uncomplicated type 2 diabetes
Am J Physiol Endocrinol Metab. 2024 Mar 27. doi: 10.1152/ajpendo.00392.2023. Online ahead of print.ABSTRACTLong-term hyperglycemia in individuals with type 2 diabetes can detrimentally impact pulmonary function and muscle oxygenation. As a result, these factors can impede the body's adaptation to physical exertion. We aimed to evaluate the oxygen pathway during maximal exercise among overweight/obese individuals with uncomplicated type 2 diabetes, in comparison with a group of matched overweight/obese individuals without diabetes, specifically concentrating on the effects on pulmonary function and muscle oxygenation. Fifte...
Source: Am J Physiol Endocri... - March 27, 2024 Category: Endocrinology Authors: Islem Jlali Imen Touil Hassen Ibn Hadj Amor Mohamed Amine Bouzid Omar Hammouda Elsa Heyman Pierre Fontaine Hamdi Chtourou Remi Rabasa-Lhoret Georges Baquet Semah Tagougui Source Type: research
Effects of Follicle Stimulating Hormone on Energy Balance and Tissue Metabolic Health After Loss of Ovarian Function
Am J Physiol Endocrinol Metab. 2024 Mar 27. doi: 10.1152/ajpendo.00400.2023. Online ahead of print.ABSTRACTLoss of ovarian function imparts increased susceptibility to obesity and metabolic disease. These effects are largely attributed to decreased estradiol (E2), but the role of increased follicle stimulating hormone (FSH) in modulating energy balance has not been fully investigated. Previous work that blocked FSH binding to its receptor in mice suggested this hormone may play a part in modulating body weight and energy expenditure after ovariectomy. We used an alternate approach to isolate the individual and combined con...
Source: Am J Physiol Endocri... - March 27, 2024 Category: Endocrinology Authors: Andrew E Libby Claudia Solt Matthew Jackman Vanessa Sherk Rebecca M Foright Ginger C Johnson Thi-Tina Nguyen Matthew Breit Nicholas Hulett Michael Rudolph Paul A Roberson Elizabeth Wellberg Purevsuren Jambal Rebecca L Scalzo Janine Higgins T Rajendra Kuma Source Type: research
Impaired muscle oxygenation despite normal pulmonary function in uncomplicated type 2 diabetes
Am J Physiol Endocrinol Metab. 2024 Mar 27. doi: 10.1152/ajpendo.00392.2023. Online ahead of print.ABSTRACTLong-term hyperglycemia in individuals with type 2 diabetes can detrimentally impact pulmonary function and muscle oxygenation. As a result, these factors can impede the body's adaptation to physical exertion. We aimed to evaluate the oxygen pathway during maximal exercise among overweight/obese individuals with uncomplicated type 2 diabetes, in comparison with a group of matched overweight/obese individuals without diabetes, specifically concentrating on the effects on pulmonary function and muscle oxygenation. Fifte...
Source: Am J Physiol Endocri... - March 27, 2024 Category: Endocrinology Authors: Islem Jlali Imen Touil Hassen Ibn Hadj Amor Mohamed Amine Bouzid Omar Hammouda Elsa Heyman Pierre Fontaine Hamdi Chtourou Remi Rabasa-Lhoret Georges Baquet Semah Tagougui Source Type: research
Effects of Follicle Stimulating Hormone on Energy Balance and Tissue Metabolic Health After Loss of Ovarian Function
Am J Physiol Endocrinol Metab. 2024 Mar 27. doi: 10.1152/ajpendo.00400.2023. Online ahead of print.ABSTRACTLoss of ovarian function imparts increased susceptibility to obesity and metabolic disease. These effects are largely attributed to decreased estradiol (E2), but the role of increased follicle stimulating hormone (FSH) in modulating energy balance has not been fully investigated. Previous work that blocked FSH binding to its receptor in mice suggested this hormone may play a part in modulating body weight and energy expenditure after ovariectomy. We used an alternate approach to isolate the individual and combined con...
Source: Am J Physiol Endocri... - March 27, 2024 Category: Endocrinology Authors: Andrew E Libby Claudia Solt Matthew Jackman Vanessa Sherk Rebecca M Foright Ginger C Johnson Thi-Tina Nguyen Matthew Breit Nicholas Hulett Michael Rudolph Paul A Roberson Elizabeth Wellberg Purevsuren Jambal Rebecca L Scalzo Janine Higgins T Rajendra Kuma Source Type: research
Impaired muscle oxygenation despite normal pulmonary function in uncomplicated type 2 diabetes
Am J Physiol Endocrinol Metab. 2024 Mar 27. doi: 10.1152/ajpendo.00392.2023. Online ahead of print.ABSTRACTLong-term hyperglycemia in individuals with type 2 diabetes can detrimentally impact pulmonary function and muscle oxygenation. As a result, these factors can impede the body's adaptation to physical exertion. We aimed to evaluate the oxygen pathway during maximal exercise among overweight/obese individuals with uncomplicated type 2 diabetes, in comparison with a group of matched overweight/obese individuals without diabetes, specifically concentrating on the effects on pulmonary function and muscle oxygenation. Fifte...
Source: Am J Physiol Endocri... - March 27, 2024 Category: Endocrinology Authors: Islem Jlali Imen Touil Hassen Ibn Hadj Amor Mohamed Amine Bouzid Omar Hammouda Elsa Heyman Pierre Fontaine Hamdi Chtourou Remi Rabasa-Lhoret Georges Baquet Semah Tagougui Source Type: research
Effects of Follicle Stimulating Hormone on Energy Balance and Tissue Metabolic Health After Loss of Ovarian Function
Am J Physiol Endocrinol Metab. 2024 Mar 27. doi: 10.1152/ajpendo.00400.2023. Online ahead of print.ABSTRACTLoss of ovarian function imparts increased susceptibility to obesity and metabolic disease. These effects are largely attributed to decreased estradiol (E2), but the role of increased follicle stimulating hormone (FSH) in modulating energy balance has not been fully investigated. Previous work that blocked FSH binding to its receptor in mice suggested this hormone may play a part in modulating body weight and energy expenditure after ovariectomy. We used an alternate approach to isolate the individual and combined con...
Source: Am J Physiol Endocri... - March 27, 2024 Category: Endocrinology Authors: Andrew E Libby Claudia Solt Matthew Jackman Vanessa Sherk Rebecca M Foright Ginger C Johnson Thi-Tina Nguyen Matthew Breit Nicholas Hulett Michael Rudolph Paul A Roberson Elizabeth Wellberg Purevsuren Jambal Rebecca L Scalzo Janine Higgins T Rajendra Kuma Source Type: research
Impaired muscle oxygenation despite normal pulmonary function in uncomplicated type 2 diabetes
Am J Physiol Endocrinol Metab. 2024 Mar 27. doi: 10.1152/ajpendo.00392.2023. Online ahead of print.ABSTRACTLong-term hyperglycemia in individuals with type 2 diabetes can detrimentally impact pulmonary function and muscle oxygenation. As a result, these factors can impede the body's adaptation to physical exertion. We aimed to evaluate the oxygen pathway during maximal exercise among overweight/obese individuals with uncomplicated type 2 diabetes, in comparison with a group of matched overweight/obese individuals without diabetes, specifically concentrating on the effects on pulmonary function and muscle oxygenation. Fifte...
Source: Am J Physiol Endocri... - March 27, 2024 Category: Endocrinology Authors: Islem Jlali Imen Touil Hassen Ibn Hadj Amor Mohamed Amine Bouzid Omar Hammouda Elsa Heyman Pierre Fontaine Hamdi Chtourou Remi Rabasa-Lhoret Georges Baquet Semah Tagougui Source Type: research
Effects of Follicle Stimulating Hormone on Energy Balance and Tissue Metabolic Health After Loss of Ovarian Function
Am J Physiol Endocrinol Metab. 2024 Mar 27. doi: 10.1152/ajpendo.00400.2023. Online ahead of print.ABSTRACTLoss of ovarian function imparts increased susceptibility to obesity and metabolic disease. These effects are largely attributed to decreased estradiol (E2), but the role of increased follicle stimulating hormone (FSH) in modulating energy balance has not been fully investigated. Previous work that blocked FSH binding to its receptor in mice suggested this hormone may play a part in modulating body weight and energy expenditure after ovariectomy. We used an alternate approach to isolate the individual and combined con...
Source: Am J Physiol Endocri... - March 27, 2024 Category: Endocrinology Authors: Andrew E Libby Claudia Solt Matthew Jackman Vanessa Sherk Rebecca M Foright Ginger C Johnson Thi-Tina Nguyen Matthew Breit Nicholas Hulett Michael Rudolph Paul A Roberson Elizabeth Wellberg Purevsuren Jambal Rebecca L Scalzo Janine Higgins T Rajendra Kuma Source Type: research
Impaired muscle oxygenation despite normal pulmonary function in uncomplicated type 2 diabetes
Am J Physiol Endocrinol Metab. 2024 Mar 27. doi: 10.1152/ajpendo.00392.2023. Online ahead of print.ABSTRACTLong-term hyperglycemia in individuals with type 2 diabetes can detrimentally impact pulmonary function and muscle oxygenation. As a result, these factors can impede the body's adaptation to physical exertion. We aimed to evaluate the oxygen pathway during maximal exercise among overweight/obese individuals with uncomplicated type 2 diabetes, in comparison with a group of matched overweight/obese individuals without diabetes, specifically concentrating on the effects on pulmonary function and muscle oxygenation. Fifte...
Source: Am J Physiol Endocri... - March 27, 2024 Category: Endocrinology Authors: Islem Jlali Imen Touil Hassen Ibn Hadj Amor Mohamed Amine Bouzid Omar Hammouda Elsa Heyman Pierre Fontaine Hamdi Chtourou Remi Rabasa-Lhoret Georges Baquet Semah Tagougui Source Type: research
Effects of Follicle Stimulating Hormone on Energy Balance and Tissue Metabolic Health After Loss of Ovarian Function
Am J Physiol Endocrinol Metab. 2024 Mar 27. doi: 10.1152/ajpendo.00400.2023. Online ahead of print.ABSTRACTLoss of ovarian function imparts increased susceptibility to obesity and metabolic disease. These effects are largely attributed to decreased estradiol (E2), but the role of increased follicle stimulating hormone (FSH) in modulating energy balance has not been fully investigated. Previous work that blocked FSH binding to its receptor in mice suggested this hormone may play a part in modulating body weight and energy expenditure after ovariectomy. We used an alternate approach to isolate the individual and combined con...
Source: Am J Physiol Endocri... - March 27, 2024 Category: Endocrinology Authors: Andrew E Libby Claudia Solt Matthew Jackman Vanessa Sherk Rebecca M Foright Ginger C Johnson Thi-Tina Nguyen Matthew Breit Nicholas Hulett Michael Rudolph Paul A Roberson Elizabeth Wellberg Purevsuren Jambal Rebecca L Scalzo Janine Higgins T Rajendra Kuma Source Type: research
