Estimating Insulin Sensitivity and Beta-Cell Function from the Oral Glucose Tolerance Test: Validation of a new Insulin Sensitivity and Secretion (ISS) Model
Am J Physiol Endocrinol Metab. 2023 Dec 6. doi: 10.1152/ajpendo.00189.2023. Online ahead of print.ABSTRACTEfficient and accurate methods to estimate insulin sensitivity (SI) and beta-cell function (BCF) are of great importance for studying the pathogenesis and treatment effectiveness of type 2 diabetes. Existing methods range in sensitivity, input data and technical requirements. Oral glucose tolerance tests (OGTTs) are preferred because they are simpler and more physiological than intravenous methods. However, current analytical methods for OGTT-derived SI and BCF also range in complexity; the oral minimal models require ...
Source: Am J Physiol Endocri... - December 6, 2023 Category: Endocrinology Authors: Joon Ha Stephanie T Chung Max Springer Joon Young Kim Phil Chen Aaryan Chhabra Melanie G Cree Cecilia Diniz Behn Anne E Sumner Silva A Arslanian Arthur S Sherman Source Type: research
Estimating Insulin Sensitivity and Beta-Cell Function from the Oral Glucose Tolerance Test: Validation of a new Insulin Sensitivity and Secretion (ISS) Model
Am J Physiol Endocrinol Metab. 2023 Dec 6. doi: 10.1152/ajpendo.00189.2023. Online ahead of print.ABSTRACTEfficient and accurate methods to estimate insulin sensitivity (SI) and beta-cell function (BCF) are of great importance for studying the pathogenesis and treatment effectiveness of type 2 diabetes. Existing methods range in sensitivity, input data and technical requirements. Oral glucose tolerance tests (OGTTs) are preferred because they are simpler and more physiological than intravenous methods. However, current analytical methods for OGTT-derived SI and BCF also range in complexity; the oral minimal models require ...
Source: Am J Physiol Endocri... - December 6, 2023 Category: Endocrinology Authors: Joon Ha Stephanie T Chung Max Springer Joon Young Kim Phil Chen Aaryan Chhabra Melanie G Cree Cecilia Diniz Behn Anne E Sumner Silva A Arslanian Arthur S Sherman Source Type: research
Estimating Insulin Sensitivity and Beta-Cell Function from the Oral Glucose Tolerance Test: Validation of a new Insulin Sensitivity and Secretion (ISS) Model
Am J Physiol Endocrinol Metab. 2023 Dec 6. doi: 10.1152/ajpendo.00189.2023. Online ahead of print.ABSTRACTEfficient and accurate methods to estimate insulin sensitivity (SI) and beta-cell function (BCF) are of great importance for studying the pathogenesis and treatment effectiveness of type 2 diabetes. Existing methods range in sensitivity, input data and technical requirements. Oral glucose tolerance tests (OGTTs) are preferred because they are simpler and more physiological than intravenous methods. However, current analytical methods for OGTT-derived SI and BCF also range in complexity; the oral minimal models require ...
Source: Am J Physiol Endocri... - December 6, 2023 Category: Endocrinology Authors: Joon Ha Stephanie T Chung Max Springer Joon Young Kim Phil Chen Aaryan Chhabra Melanie G Cree Cecilia Diniz Behn Anne E Sumner Silva A Arslanian Arthur S Sherman Source Type: research
Estimating Insulin Sensitivity and Beta-Cell Function from the Oral Glucose Tolerance Test: Validation of a new Insulin Sensitivity and Secretion (ISS) Model
Am J Physiol Endocrinol Metab. 2023 Dec 6. doi: 10.1152/ajpendo.00189.2023. Online ahead of print.ABSTRACTEfficient and accurate methods to estimate insulin sensitivity (SI) and beta-cell function (BCF) are of great importance for studying the pathogenesis and treatment effectiveness of type 2 diabetes. Existing methods range in sensitivity, input data and technical requirements. Oral glucose tolerance tests (OGTTs) are preferred because they are simpler and more physiological than intravenous methods. However, current analytical methods for OGTT-derived SI and BCF also range in complexity; the oral minimal models require ...
Source: Am J Physiol Endocri... - December 6, 2023 Category: Endocrinology Authors: Joon Ha Stephanie T Chung Max Springer Joon Young Kim Phil Chen Aaryan Chhabra Melanie G Cree Cecilia Diniz Behn Anne E Sumner Silva A Arslanian Arthur S Sherman Source Type: research
Estimating Insulin Sensitivity and Beta-Cell Function from the Oral Glucose Tolerance Test: Validation of a new Insulin Sensitivity and Secretion (ISS) Model
Am J Physiol Endocrinol Metab. 2023 Dec 6. doi: 10.1152/ajpendo.00189.2023. Online ahead of print.ABSTRACTEfficient and accurate methods to estimate insulin sensitivity (SI) and beta-cell function (BCF) are of great importance for studying the pathogenesis and treatment effectiveness of type 2 diabetes. Existing methods range in sensitivity, input data and technical requirements. Oral glucose tolerance tests (OGTTs) are preferred because they are simpler and more physiological than intravenous methods. However, current analytical methods for OGTT-derived SI and BCF also range in complexity; the oral minimal models require ...
Source: Am J Physiol Endocri... - December 6, 2023 Category: Endocrinology Authors: Joon Ha Stephanie T Chung Max Springer Joon Young Kim Phil Chen Aaryan Chhabra Melanie G Cree Cecilia Diniz Behn Anne E Sumner Silva A Arslanian Arthur S Sherman Source Type: research
Absence of < em > Slc39a14/Zip14 < /em > in mouse pancreatic beta cells results in hyperinsulinemia
Conclusion This study provided new insights into the contribution of metal transporter ZIP14-mediated intracellular zinc trafficking in glucose-stimulated insulin secretion and subsequent metabolic responses.PMID:38019082 | DOI:10.1152/ajpendo.00117.2023 (Source: Am J Physiol Endocri...)
Source: Am J Physiol Endocri... - November 29, 2023 Category: Endocrinology Authors: Yu-Han Hung Yongeun Kim Samuel Blake Mitchell Trista Lee Thorn Tolunay Beker Aydemir Source Type: research
Functional hypothalamic amenorrhea: gut microbiota composition and the effects of exogenous estrogen administration
Am J Physiol Endocrinol Metab. 2023 Nov 29. doi: 10.1152/ajpendo.00281.2023. Online ahead of print.ABSTRACTFunctional hypothalamic amenorrhea (FHA) is characterized by estrogen deficiency that significantly impacts on metabolic, bone, cardiovascular, mental, and reproductive health. Given the importance of environmental factors such as stress, and body composition, and particularly considering the importance of estrogens in regulating the gut microbiota, some changes in the intestinal microenvironment are expected when all of these factors occur simultaneously. We aimed to assess whether the gut microbiota composition is a...
Source: Am J Physiol Endocri... - November 29, 2023 Category: Endocrinology Authors: Giovanna Notaristefano Francesca Romana Ponziani Monia Ranalli Alice Diterlizzi Martina Asia Policriti Leonardo Stella Fabio Del Zompo Francesca Fianchi Anna Picca Valentina Petito Federica Del Chierico Matteo Scanu Francesca Toto Lorenza Putignani Emanue Source Type: research
Skeletal muscle-specific inducible AMPK α1/α2 knockout mice develop muscle weakness, glycogen depletion, and fibrosis that persists during disuse atrophy
Am J Physiol Endocrinol Metab. 2023 Nov 29. doi: 10.1152/ajpendo.00261.2023. Online ahead of print.ABSTRACTThe 5' adenosine monophosphate-activated protein kinase (AMPK) is an important skeletal muscle regulator implicated as a possible therapeutic target to ameliorate the local undesired deconditioning of disuse atrophy. However, the muscle-specific role of AMPK in regulating muscle function, fibrosis, and transcriptional reprogramming during physical disuse are unknown. The purpose of this study was to determine how the absence of both catalytic subunits of AMPK in skeletal muscle influence muscle force production, colla...
Source: Am J Physiol Endocri... - November 29, 2023 Category: Endocrinology Authors: Jonathan J Petrocelli Jingtong Liu Elena M Yee Patrick J Ferrara Paul-Emile Bourrant Naomi M M P de Hart Sean M Tatum William J Holland Katsuhiko Funai Micah J Drummond Source Type: research
Absence of < em > Slc39a14/Zip14 < /em > in mouse pancreatic beta cells results in hyperinsulinemia
Conclusion This study provided new insights into the contribution of metal transporter ZIP14-mediated intracellular zinc trafficking in glucose-stimulated insulin secretion and subsequent metabolic responses.PMID:38019082 | DOI:10.1152/ajpendo.00117.2023 (Source: Am J Physiol Endocri...)
Source: Am J Physiol Endocri... - November 29, 2023 Category: Endocrinology Authors: Yu-Han Hung Yongeun Kim Samuel Blake Mitchell Trista Lee Thorn Tolunay Beker Aydemir Source Type: research
Functional hypothalamic amenorrhea: gut microbiota composition and the effects of exogenous estrogen administration
Am J Physiol Endocrinol Metab. 2023 Nov 29. doi: 10.1152/ajpendo.00281.2023. Online ahead of print.ABSTRACTFunctional hypothalamic amenorrhea (FHA) is characterized by estrogen deficiency that significantly impacts on metabolic, bone, cardiovascular, mental, and reproductive health. Given the importance of environmental factors such as stress, and body composition, and particularly considering the importance of estrogens in regulating the gut microbiota, some changes in the intestinal microenvironment are expected when all of these factors occur simultaneously. We aimed to assess whether the gut microbiota composition is a...
Source: Am J Physiol Endocri... - November 29, 2023 Category: Endocrinology Authors: Giovanna Notaristefano Francesca Romana Ponziani Monia Ranalli Alice Diterlizzi Martina Asia Policriti Leonardo Stella Fabio Del Zompo Francesca Fianchi Anna Picca Valentina Petito Federica Del Chierico Matteo Scanu Francesca Toto Lorenza Putignani Emanue Source Type: research
Skeletal muscle-specific inducible AMPK α1/α2 knockout mice develop muscle weakness, glycogen depletion, and fibrosis that persists during disuse atrophy
Am J Physiol Endocrinol Metab. 2023 Nov 29. doi: 10.1152/ajpendo.00261.2023. Online ahead of print.ABSTRACTThe 5' adenosine monophosphate-activated protein kinase (AMPK) is an important skeletal muscle regulator implicated as a possible therapeutic target to ameliorate the local undesired deconditioning of disuse atrophy. However, the muscle-specific role of AMPK in regulating muscle function, fibrosis, and transcriptional reprogramming during physical disuse are unknown. The purpose of this study was to determine how the absence of both catalytic subunits of AMPK in skeletal muscle influence muscle force production, colla...
Source: Am J Physiol Endocri... - November 29, 2023 Category: Endocrinology Authors: Jonathan J Petrocelli Jingtong Liu Elena M Yee Patrick J Ferrara Paul-Emile Bourrant Naomi M M P de Hart Sean M Tatum William J Holland Katsuhiko Funai Micah J Drummond Source Type: research
Absence of < em > Slc39a14/Zip14 < /em > in mouse pancreatic beta cells results in hyperinsulinemia
Conclusion This study provided new insights into the contribution of metal transporter ZIP14-mediated intracellular zinc trafficking in glucose-stimulated insulin secretion and subsequent metabolic responses.PMID:38019082 | DOI:10.1152/ajpendo.00117.2023 (Source: Am J Physiol Endocri...)
Source: Am J Physiol Endocri... - November 29, 2023 Category: Endocrinology Authors: Yu-Han Hung Yongeun Kim Samuel Blake Mitchell Trista Lee Thorn Tolunay Beker Aydemir Source Type: research
Functional hypothalamic amenorrhea: gut microbiota composition and the effects of exogenous estrogen administration
Am J Physiol Endocrinol Metab. 2023 Nov 29. doi: 10.1152/ajpendo.00281.2023. Online ahead of print.ABSTRACTFunctional hypothalamic amenorrhea (FHA) is characterized by estrogen deficiency that significantly impacts on metabolic, bone, cardiovascular, mental, and reproductive health. Given the importance of environmental factors such as stress, and body composition, and particularly considering the importance of estrogens in regulating the gut microbiota, some changes in the intestinal microenvironment are expected when all of these factors occur simultaneously. We aimed to assess whether the gut microbiota composition is a...
Source: Am J Physiol Endocri... - November 29, 2023 Category: Endocrinology Authors: Giovanna Notaristefano Francesca Romana Ponziani Monia Ranalli Alice Diterlizzi Martina Asia Policriti Leonardo Stella Fabio Del Zompo Francesca Fianchi Anna Picca Valentina Petito Federica Del Chierico Matteo Scanu Francesca Toto Lorenza Putignani Emanue Source Type: research
Skeletal muscle-specific inducible AMPK α1/α2 knockout mice develop muscle weakness, glycogen depletion, and fibrosis that persists during disuse atrophy
Am J Physiol Endocrinol Metab. 2023 Nov 29. doi: 10.1152/ajpendo.00261.2023. Online ahead of print.ABSTRACTThe 5' adenosine monophosphate-activated protein kinase (AMPK) is an important skeletal muscle regulator implicated as a possible therapeutic target to ameliorate the local undesired deconditioning of disuse atrophy. However, the muscle-specific role of AMPK in regulating muscle function, fibrosis, and transcriptional reprogramming during physical disuse are unknown. The purpose of this study was to determine how the absence of both catalytic subunits of AMPK in skeletal muscle influence muscle force production, colla...
Source: Am J Physiol Endocri... - November 29, 2023 Category: Endocrinology Authors: Jonathan J Petrocelli Jingtong Liu Elena M Yee Patrick J Ferrara Paul-Emile Bourrant Naomi M M P de Hart Sean M Tatum William J Holland Katsuhiko Funai Micah J Drummond Source Type: research
Absence of < em > Slc39a14/Zip14 < /em > in mouse pancreatic beta cells results in hyperinsulinemia
Conclusion This study provided new insights into the contribution of metal transporter ZIP14-mediated intracellular zinc trafficking in glucose-stimulated insulin secretion and subsequent metabolic responses.PMID:38019082 | DOI:10.1152/ajpendo.00117.2023 (Source: Am J Physiol Endocri...)
Source: Am J Physiol Endocri... - November 29, 2023 Category: Endocrinology Authors: Yu-Han Hung Yongeun Kim Samuel Blake Mitchell Trista Lee Thorn Tolunay Beker Aydemir Source Type: research
