Pharmaceutical properties of a tinted formulation of a biguanide antiseptic agent, olanexidine gluconate
Biol Pharm Bull. 2021 Nov 25. doi: 10.1248/bpb.b21-00833. Online ahead of print.ABSTRACTOlanexidine gluconate-containing preoperative antiseptic (OLG-C) is colorless, which makes it difficult to determine its area of application. To overcome this drawback, we realized a stable orange-tinted antiseptic (OLG-T) by adding new additives to OLG-C and investigated its pharmaceutical properties compared with OLG-C and povidone iodine (PVP-I). We evaluated the influence of the additives on the antimicrobial activity and adhesiveness of medical adhesives to OLG-T-applied skin by in vitro time-kill/ex vivo micropig skin assays and a...
Source: Biological and Pharmaceutical Bulletin - November 25, 2021 Category: Drugs & Pharmacology Authors: Hisae Nishioka Mari Shiozaki Takuya Nii Nahoki Hayashi Akifumi Hagi Source Type: research

Pharmaceutical properties of a tinted formulation of a biguanide antiseptic agent, olanexidine gluconate
Biol Pharm Bull. 2021 Nov 25. doi: 10.1248/bpb.b21-00833. Online ahead of print.ABSTRACTOlanexidine gluconate-containing preoperative antiseptic (OLG-C) is colorless, which makes it difficult to determine its area of application. To overcome this drawback, we realized a stable orange-tinted antiseptic (OLG-T) by adding new additives to OLG-C and investigated its pharmaceutical properties compared with OLG-C and povidone iodine (PVP-I). We evaluated the influence of the additives on the antimicrobial activity and adhesiveness of medical adhesives to OLG-T-applied skin by in vitro time-kill/ex vivo micropig skin assays and a...
Source: Biological and Pharmaceutical Bulletin - November 25, 2021 Category: Drugs & Pharmacology Authors: Hisae Nishioka Mari Shiozaki Takuya Nii Nahoki Hayashi Akifumi Hagi Source Type: research

Renin-angiotensin-aldosterone system inhibitors prevent the onset of oxaliplatin-induced peripheral neuropathy: A retrospective multicenter study and in vitro evaluation
We examined the effects of renin-angiotensin-aldosterone system inhibitors (RAASIs) on OIPN by performing a retrospective multicenter study and an in vitro assay. We retrospectively evaluated electronic medical records of 976 patients who underwent one or more courses of OXA-containing regimens at Ehime, Okayama, and Tokushima University Hospitals. The primary endpoint was the incidence of OIPN during or after OXA administration. The effects of RAASIs and OXA on the neurite length in PC12 cells were determined. The combined administration of an OXA-containing regimen and RAASI significantly inhibited the cumulative inciden...
Source: Biological and Pharmaceutical Bulletin - November 22, 2021 Category: Drugs & Pharmacology Authors: Mami Uchida Soichiro Ushio Takahiro Niimura Kenshi Takechi Hitoshi Kawazoe Noriaki Hidaka Akihiro Tanaka Hiroaki Araki Yoshito Zamami Keisuke Ishizawa Yoshihisa Kitamura Toshiaki Sendou Hiromu Kawasaki Hiroyuki Namba Kazuhiko Shibata Mamoru Tanaka Shingo Source Type: research

Renin-angiotensin-aldosterone system inhibitors prevent the onset of oxaliplatin-induced peripheral neuropathy: A retrospective multicenter study and in vitro evaluation
We examined the effects of renin-angiotensin-aldosterone system inhibitors (RAASIs) on OIPN by performing a retrospective multicenter study and an in vitro assay. We retrospectively evaluated electronic medical records of 976 patients who underwent one or more courses of OXA-containing regimens at Ehime, Okayama, and Tokushima University Hospitals. The primary endpoint was the incidence of OIPN during or after OXA administration. The effects of RAASIs and OXA on the neurite length in PC12 cells were determined. The combined administration of an OXA-containing regimen and RAASI significantly inhibited the cumulative inciden...
Source: Biological and Pharmaceutical Bulletin - November 22, 2021 Category: Drugs & Pharmacology Authors: Mami Uchida Soichiro Ushio Takahiro Niimura Kenshi Takechi Hitoshi Kawazoe Noriaki Hidaka Akihiro Tanaka Hiroaki Araki Yoshito Zamami Keisuke Ishizawa Yoshihisa Kitamura Toshiaki Sendou Hiromu Kawasaki Hiroyuki Namba Kazuhiko Shibata Mamoru Tanaka Shingo Source Type: research

Renin-angiotensin-aldosterone system inhibitors prevent the onset of oxaliplatin-induced peripheral neuropathy: A retrospective multicenter study and in vitro evaluation
We examined the effects of renin-angiotensin-aldosterone system inhibitors (RAASIs) on OIPN by performing a retrospective multicenter study and an in vitro assay. We retrospectively evaluated electronic medical records of 976 patients who underwent one or more courses of OXA-containing regimens at Ehime, Okayama, and Tokushima University Hospitals. The primary endpoint was the incidence of OIPN during or after OXA administration. The effects of RAASIs and OXA on the neurite length in PC12 cells were determined. The combined administration of an OXA-containing regimen and RAASI significantly inhibited the cumulative inciden...
Source: Biological and Pharmaceutical Bulletin - November 22, 2021 Category: Drugs & Pharmacology Authors: Mami Uchida Soichiro Ushio Takahiro Niimura Kenshi Takechi Hitoshi Kawazoe Noriaki Hidaka Akihiro Tanaka Hiroaki Araki Yoshito Zamami Keisuke Ishizawa Yoshihisa Kitamura Toshiaki Sendou Hiromu Kawasaki Hiroyuki Namba Kazuhiko Shibata Mamoru Tanaka Shingo Source Type: research

Machine Learning Prediction of the Three Main Input Parameters of a Simplified Physiologically Based Pharmacokinetic Model Subsequently Used to Generate Time-Dependent Plasma Concentration Data in Humans after Oral Doses of 212 Disparate Chemicals
Biol Pharm Bull. 2021 Nov 2. doi: 10.1248/bpb.b21-00769. Online ahead of print.ABSTRACTPhysiologically based pharmacokinetic (PBPK) modeling has the potential to play significant roles in estimating internal chemical exposures. The three major PBPK model input parameters (i.e., absorption rate constants, volumes of the systemic circulation, and hepatic intrinsic clearances) were generated in silico for 212 chemicals using machine learning algorithms. These input parameters were calculated based on sets of between 17 and 65 chemical properties that were generated by in silico prediction tools before being processed by machi...
Source: Biological and Pharmaceutical Bulletin - November 4, 2021 Category: Drugs & Pharmacology Authors: Yusuke Kamiya Kentaro Handa Tomonori Miura Junya Ohori Airi Kato Makiko Shimizu Masato Kitajima Hiroshi Yamazaki Source Type: research

Salvia miltiorrhiza prevents methylglyoxal-induced glucotoxicity via the regulation of apoptosis-related pathways and the glyoxalase system in human umbilical vein endothelial cells
Biol Pharm Bull. 2021 Nov 3. doi: 10.1248/bpb.b21-00507. Online ahead of print.ABSTRACTMethylglyoxal (MGO), which is produced as a byproduct of glucose metabolism, is the leading to diabetic cardiovascular complications. Salvia miltiorrhiza Bunge (Lamiaceae) has been reported as a potential plant to control diabetes and cardiovascular disease. However, no report exists on the effect of Salvia miltiorrhiza Bunge extract (SME) on MGO-induced glucotoxicity in human umbilical vein endothelial cells (HUVECs).We demonstrated the protective effects of SME (1, 5, and 10 µg/mL) and its components against MGO-induced endotheli...
Source: Biological and Pharmaceutical Bulletin - November 4, 2021 Category: Drugs & Pharmacology Authors: Jae Sung Kim Jae Hyuk Lee Seong Min Hong KyoHee Cho Sun Yeou Kim Source Type: research

Machine Learning Prediction of the Three Main Input Parameters of a Simplified Physiologically Based Pharmacokinetic Model Subsequently Used to Generate Time-Dependent Plasma Concentration Data in Humans after Oral Doses of 212 Disparate Chemicals
Biol Pharm Bull. 2021 Nov 2. doi: 10.1248/bpb.b21-00769. Online ahead of print.ABSTRACTPhysiologically based pharmacokinetic (PBPK) modeling has the potential to play significant roles in estimating internal chemical exposures. The three major PBPK model input parameters (i.e., absorption rate constants, volumes of the systemic circulation, and hepatic intrinsic clearances) were generated in silico for 212 chemicals using machine learning algorithms. These input parameters were calculated based on sets of between 17 and 65 chemical properties that were generated by in silico prediction tools before being processed by machi...
Source: Biological and Pharmaceutical Bulletin - November 4, 2021 Category: Drugs & Pharmacology Authors: Yusuke Kamiya Kentaro Handa Tomonori Miura Junya Ohori Airi Kato Makiko Shimizu Masato Kitajima Hiroshi Yamazaki Source Type: research

Salvia miltiorrhiza prevents methylglyoxal-induced glucotoxicity via the regulation of apoptosis-related pathways and the glyoxalase system in human umbilical vein endothelial cells
Biol Pharm Bull. 2021 Nov 3. doi: 10.1248/bpb.b21-00507. Online ahead of print.ABSTRACTMethylglyoxal (MGO), which is produced as a byproduct of glucose metabolism, is the leading to diabetic cardiovascular complications. Salvia miltiorrhiza Bunge (Lamiaceae) has been reported as a potential plant to control diabetes and cardiovascular disease. However, no report exists on the effect of Salvia miltiorrhiza Bunge extract (SME) on MGO-induced glucotoxicity in human umbilical vein endothelial cells (HUVECs).We demonstrated the protective effects of SME (1, 5, and 10 µg/mL) and its components against MGO-induced endotheli...
Source: Biological and Pharmaceutical Bulletin - November 4, 2021 Category: Drugs & Pharmacology Authors: Jae Sung Kim Jae Hyuk Lee Seong Min Hong KyoHee Cho Sun Yeou Kim Source Type: research

Machine Learning Prediction of the Three Main Input Parameters of a Simplified Physiologically Based Pharmacokinetic Model Subsequently Used to Generate Time-Dependent Plasma Concentration Data in Humans after Oral Doses of 212 Disparate Chemicals
Biol Pharm Bull. 2021 Nov 2. doi: 10.1248/bpb.b21-00769. Online ahead of print.ABSTRACTPhysiologically based pharmacokinetic (PBPK) modeling has the potential to play significant roles in estimating internal chemical exposures. The three major PBPK model input parameters (i.e., absorption rate constants, volumes of the systemic circulation, and hepatic intrinsic clearances) were generated in silico for 212 chemicals using machine learning algorithms. These input parameters were calculated based on sets of between 17 and 65 chemical properties that were generated by in silico prediction tools before being processed by machi...
Source: Biological and Pharmaceutical Bulletin - November 4, 2021 Category: Drugs & Pharmacology Authors: Yusuke Kamiya Kentaro Handa Tomonori Miura Junya Ohori Airi Kato Makiko Shimizu Masato Kitajima Hiroshi Yamazaki Source Type: research

Salvia miltiorrhiza prevents methylglyoxal-induced glucotoxicity via the regulation of apoptosis-related pathways and the glyoxalase system in human umbilical vein endothelial cells
Biol Pharm Bull. 2021 Nov 3. doi: 10.1248/bpb.b21-00507. Online ahead of print.ABSTRACTMethylglyoxal (MGO), which is produced as a byproduct of glucose metabolism, is the leading to diabetic cardiovascular complications. Salvia miltiorrhiza Bunge (Lamiaceae) has been reported as a potential plant to control diabetes and cardiovascular disease. However, no report exists on the effect of Salvia miltiorrhiza Bunge extract (SME) on MGO-induced glucotoxicity in human umbilical vein endothelial cells (HUVECs).We demonstrated the protective effects of SME (1, 5, and 10 µg/mL) and its components against MGO-induced endotheli...
Source: Biological and Pharmaceutical Bulletin - November 4, 2021 Category: Drugs & Pharmacology Authors: Jae Sung Kim Jae Hyuk Lee Seong Min Hong KyoHee Cho Sun Yeou Kim Source Type: research

Machine Learning Prediction of the Three Main Input Parameters of a Simplified Physiologically Based Pharmacokinetic Model Subsequently Used to Generate Time-Dependent Plasma Concentration Data in Humans after Oral Doses of 212 Disparate Chemicals
Biol Pharm Bull. 2021 Nov 2. doi: 10.1248/bpb.b21-00769. Online ahead of print.ABSTRACTPhysiologically based pharmacokinetic (PBPK) modeling has the potential to play significant roles in estimating internal chemical exposures. The three major PBPK model input parameters (i.e., absorption rate constants, volumes of the systemic circulation, and hepatic intrinsic clearances) were generated in silico for 212 chemicals using machine learning algorithms. These input parameters were calculated based on sets of between 17 and 65 chemical properties that were generated by in silico prediction tools before being processed by machi...
Source: Biological and Pharmaceutical Bulletin - November 4, 2021 Category: Drugs & Pharmacology Authors: Yusuke Kamiya Kentaro Handa Tomonori Miura Junya Ohori Airi Kato Makiko Shimizu Masato Kitajima Hiroshi Yamazaki Source Type: research

Salvia miltiorrhiza prevents methylglyoxal-induced glucotoxicity via the regulation of apoptosis-related pathways and the glyoxalase system in human umbilical vein endothelial cells
Biol Pharm Bull. 2021 Nov 3. doi: 10.1248/bpb.b21-00507. Online ahead of print.ABSTRACTMethylglyoxal (MGO), which is produced as a byproduct of glucose metabolism, is the leading to diabetic cardiovascular complications. Salvia miltiorrhiza Bunge (Lamiaceae) has been reported as a potential plant to control diabetes and cardiovascular disease. However, no report exists on the effect of Salvia miltiorrhiza Bunge extract (SME) on MGO-induced glucotoxicity in human umbilical vein endothelial cells (HUVECs).We demonstrated the protective effects of SME (1, 5, and 10 µg/mL) and its components against MGO-induced endotheli...
Source: Biological and Pharmaceutical Bulletin - November 4, 2021 Category: Drugs & Pharmacology Authors: Jae Sung Kim Jae Hyuk Lee Seong Min Hong KyoHee Cho Sun Yeou Kim Source Type: research

Machine Learning Prediction of the Three Main Input Parameters of a Simplified Physiologically Based Pharmacokinetic Model Subsequently Used to Generate Time-Dependent Plasma Concentration Data in Humans after Oral Doses of 212 Disparate Chemicals
Biol Pharm Bull. 2021 Nov 2. doi: 10.1248/bpb.b21-00769. Online ahead of print.ABSTRACTPhysiologically based pharmacokinetic (PBPK) modeling has the potential to play significant roles in estimating internal chemical exposures. The three major PBPK model input parameters (i.e., absorption rate constants, volumes of the systemic circulation, and hepatic intrinsic clearances) were generated in silico for 212 chemicals using machine learning algorithms. These input parameters were calculated based on sets of between 17 and 65 chemical properties that were generated by in silico prediction tools before being processed by machi...
Source: Biological and Pharmaceutical Bulletin - November 4, 2021 Category: Drugs & Pharmacology Authors: Yusuke Kamiya Kentaro Handa Tomonori Miura Junya Ohori Airi Kato Makiko Shimizu Masato Kitajima Hiroshi Yamazaki Source Type: research

Salvia miltiorrhiza prevents methylglyoxal-induced glucotoxicity via the regulation of apoptosis-related pathways and the glyoxalase system in human umbilical vein endothelial cells
Biol Pharm Bull. 2021 Nov 3. doi: 10.1248/bpb.b21-00507. Online ahead of print.ABSTRACTMethylglyoxal (MGO), which is produced as a byproduct of glucose metabolism, is the leading to diabetic cardiovascular complications. Salvia miltiorrhiza Bunge (Lamiaceae) has been reported as a potential plant to control diabetes and cardiovascular disease. However, no report exists on the effect of Salvia miltiorrhiza Bunge extract (SME) on MGO-induced glucotoxicity in human umbilical vein endothelial cells (HUVECs).We demonstrated the protective effects of SME (1, 5, and 10 µg/mL) and its components against MGO-induced endotheli...
Source: Biological and Pharmaceutical Bulletin - November 4, 2021 Category: Drugs & Pharmacology Authors: Jae Sung Kim Jae Hyuk Lee Seong Min Hong KyoHee Cho Sun Yeou Kim Source Type: research

Machine Learning Prediction of the Three Main Input Parameters of a Simplified Physiologically Based Pharmacokinetic Model Subsequently Used to Generate Time-Dependent Plasma Concentration Data in Humans after Oral Doses of 212 Disparate Chemicals
Biol Pharm Bull. 2021 Nov 2. doi: 10.1248/bpb.b21-00769. Online ahead of print.ABSTRACTPhysiologically based pharmacokinetic (PBPK) modeling has the potential to play significant roles in estimating internal chemical exposures. The three major PBPK model input parameters (i.e., absorption rate constants, volumes of the systemic circulation, and hepatic intrinsic clearances) were generated in silico for 212 chemicals using machine learning algorithms. These input parameters were calculated based on sets of between 17 and 65 chemical properties that were generated by in silico prediction tools before being processed by machi...
Source: Biological and Pharmaceutical Bulletin - November 4, 2021 Category: Drugs & Pharmacology Authors: Yusuke Kamiya Kentaro Handa Tomonori Miura Junya Ohori Airi Kato Makiko Shimizu Masato Kitajima Hiroshi Yamazaki Source Type: research

Salvia miltiorrhiza prevents methylglyoxal-induced glucotoxicity via the regulation of apoptosis-related pathways and the glyoxalase system in human umbilical vein endothelial cells
Biol Pharm Bull. 2021 Nov 3. doi: 10.1248/bpb.b21-00507. Online ahead of print.ABSTRACTMethylglyoxal (MGO), which is produced as a byproduct of glucose metabolism, is the leading to diabetic cardiovascular complications. Salvia miltiorrhiza Bunge (Lamiaceae) has been reported as a potential plant to control diabetes and cardiovascular disease. However, no report exists on the effect of Salvia miltiorrhiza Bunge extract (SME) on MGO-induced glucotoxicity in human umbilical vein endothelial cells (HUVECs).We demonstrated the protective effects of SME (1, 5, and 10 µg/mL) and its components against MGO-induced endotheli...
Source: Biological and Pharmaceutical Bulletin - November 4, 2021 Category: Drugs & Pharmacology Authors: Jae Sung Kim Jae Hyuk Lee Seong Min Hong KyoHee Cho Sun Yeou Kim Source Type: research

Machine Learning Prediction of the Three Main Input Parameters of a Simplified Physiologically Based Pharmacokinetic Model Subsequently Used to Generate Time-Dependent Plasma Concentration Data in Humans after Oral Doses of 212 Disparate Chemicals
Biol Pharm Bull. 2021 Nov 2. doi: 10.1248/bpb.b21-00769. Online ahead of print.ABSTRACTPhysiologically based pharmacokinetic (PBPK) modeling has the potential to play significant roles in estimating internal chemical exposures. The three major PBPK model input parameters (i.e., absorption rate constants, volumes of the systemic circulation, and hepatic intrinsic clearances) were generated in silico for 212 chemicals using machine learning algorithms. These input parameters were calculated based on sets of between 17 and 65 chemical properties that were generated by in silico prediction tools before being processed by machi...
Source: Biological and Pharmaceutical Bulletin - November 4, 2021 Category: Drugs & Pharmacology Authors: Yusuke Kamiya Kentaro Handa Tomonori Miura Junya Ohori Airi Kato Makiko Shimizu Masato Kitajima Hiroshi Yamazaki Source Type: research

Salvia miltiorrhiza prevents methylglyoxal-induced glucotoxicity via the regulation of apoptosis-related pathways and the glyoxalase system in human umbilical vein endothelial cells
Biol Pharm Bull. 2021 Nov 3. doi: 10.1248/bpb.b21-00507. Online ahead of print.ABSTRACTMethylglyoxal (MGO), which is produced as a byproduct of glucose metabolism, is the leading to diabetic cardiovascular complications. Salvia miltiorrhiza Bunge (Lamiaceae) has been reported as a potential plant to control diabetes and cardiovascular disease. However, no report exists on the effect of Salvia miltiorrhiza Bunge extract (SME) on MGO-induced glucotoxicity in human umbilical vein endothelial cells (HUVECs).We demonstrated the protective effects of SME (1, 5, and 10 µg/mL) and its components against MGO-induced endotheli...
Source: Biological and Pharmaceutical Bulletin - November 4, 2021 Category: Drugs & Pharmacology Authors: Jae Sung Kim Jae Hyuk Lee Seong Min Hong KyoHee Cho Sun Yeou Kim Source Type: research

Machine Learning Prediction of the Three Main Input Parameters of a Simplified Physiologically Based Pharmacokinetic Model Subsequently Used to Generate Time-Dependent Plasma Concentration Data in Humans after Oral Doses of 212 Disparate Chemicals
Biol Pharm Bull. 2021 Nov 2. doi: 10.1248/bpb.b21-00769. Online ahead of print.ABSTRACTPhysiologically based pharmacokinetic (PBPK) modeling has the potential to play significant roles in estimating internal chemical exposures. The three major PBPK model input parameters (i.e., absorption rate constants, volumes of the systemic circulation, and hepatic intrinsic clearances) were generated in silico for 212 chemicals using machine learning algorithms. These input parameters were calculated based on sets of between 17 and 65 chemical properties that were generated by in silico prediction tools before being processed by machi...
Source: Biological and Pharmaceutical Bulletin - November 4, 2021 Category: Drugs & Pharmacology Authors: Yusuke Kamiya Kentaro Handa Tomonori Miura Junya Ohori Airi Kato Makiko Shimizu Masato Kitajima Hiroshi Yamazaki Source Type: research

Salvia miltiorrhiza prevents methylglyoxal-induced glucotoxicity via the regulation of apoptosis-related pathways and the glyoxalase system in human umbilical vein endothelial cells
Biol Pharm Bull. 2021 Nov 3. doi: 10.1248/bpb.b21-00507. Online ahead of print.ABSTRACTMethylglyoxal (MGO), which is produced as a byproduct of glucose metabolism, is the leading to diabetic cardiovascular complications. Salvia miltiorrhiza Bunge (Lamiaceae) has been reported as a potential plant to control diabetes and cardiovascular disease. However, no report exists on the effect of Salvia miltiorrhiza Bunge extract (SME) on MGO-induced glucotoxicity in human umbilical vein endothelial cells (HUVECs).We demonstrated the protective effects of SME (1, 5, and 10 µg/mL) and its components against MGO-induced endotheli...
Source: Biological and Pharmaceutical Bulletin - November 4, 2021 Category: Drugs & Pharmacology Authors: Jae Sung Kim Jae Hyuk Lee Seong Min Hong KyoHee Cho Sun Yeou Kim Source Type: research

Machine Learning Prediction of the Three Main Input Parameters of a Simplified Physiologically Based Pharmacokinetic Model Subsequently Used to Generate Time-Dependent Plasma Concentration Data in Humans after Oral Doses of 212 Disparate Chemicals
Biol Pharm Bull. 2021 Nov 2. doi: 10.1248/bpb.b21-00769. Online ahead of print.ABSTRACTPhysiologically based pharmacokinetic (PBPK) modeling has the potential to play significant roles in estimating internal chemical exposures. The three major PBPK model input parameters (i.e., absorption rate constants, volumes of the systemic circulation, and hepatic intrinsic clearances) were generated in silico for 212 chemicals using machine learning algorithms. These input parameters were calculated based on sets of between 17 and 65 chemical properties that were generated by in silico prediction tools before being processed by machi...
Source: Biological and Pharmaceutical Bulletin - November 4, 2021 Category: Drugs & Pharmacology Authors: Yusuke Kamiya Kentaro Handa Tomonori Miura Junya Ohori Airi Kato Makiko Shimizu Masato Kitajima Hiroshi Yamazaki Source Type: research

Salvia miltiorrhiza prevents methylglyoxal-induced glucotoxicity via the regulation of apoptosis-related pathways and the glyoxalase system in human umbilical vein endothelial cells
Biol Pharm Bull. 2021 Nov 3. doi: 10.1248/bpb.b21-00507. Online ahead of print.ABSTRACTMethylglyoxal (MGO), which is produced as a byproduct of glucose metabolism, is the leading to diabetic cardiovascular complications. Salvia miltiorrhiza Bunge (Lamiaceae) has been reported as a potential plant to control diabetes and cardiovascular disease. However, no report exists on the effect of Salvia miltiorrhiza Bunge extract (SME) on MGO-induced glucotoxicity in human umbilical vein endothelial cells (HUVECs).We demonstrated the protective effects of SME (1, 5, and 10 µg/mL) and its components against MGO-induced endotheli...
Source: Biological and Pharmaceutical Bulletin - November 4, 2021 Category: Drugs & Pharmacology Authors: Jae Sung Kim Jae Hyuk Lee Seong Min Hong KyoHee Cho Sun Yeou Kim Source Type: research

Machine Learning Prediction of the Three Main Input Parameters of a Simplified Physiologically Based Pharmacokinetic Model Subsequently Used to Generate Time-Dependent Plasma Concentration Data in Humans after Oral Doses of 212 Disparate Chemicals
Biol Pharm Bull. 2021 Nov 2. doi: 10.1248/bpb.b21-00769. Online ahead of print.ABSTRACTPhysiologically based pharmacokinetic (PBPK) modeling has the potential to play significant roles in estimating internal chemical exposures. The three major PBPK model input parameters (i.e., absorption rate constants, volumes of the systemic circulation, and hepatic intrinsic clearances) were generated in silico for 212 chemicals using machine learning algorithms. These input parameters were calculated based on sets of between 17 and 65 chemical properties that were generated by in silico prediction tools before being processed by machi...
Source: Biological and Pharmaceutical Bulletin - November 4, 2021 Category: Drugs & Pharmacology Authors: Yusuke Kamiya Kentaro Handa Tomonori Miura Junya Ohori Airi Kato Makiko Shimizu Masato Kitajima Hiroshi Yamazaki Source Type: research

Salvia miltiorrhiza prevents methylglyoxal-induced glucotoxicity via the regulation of apoptosis-related pathways and the glyoxalase system in human umbilical vein endothelial cells
Biol Pharm Bull. 2021 Nov 3. doi: 10.1248/bpb.b21-00507. Online ahead of print.ABSTRACTMethylglyoxal (MGO), which is produced as a byproduct of glucose metabolism, is the leading to diabetic cardiovascular complications. Salvia miltiorrhiza Bunge (Lamiaceae) has been reported as a potential plant to control diabetes and cardiovascular disease. However, no report exists on the effect of Salvia miltiorrhiza Bunge extract (SME) on MGO-induced glucotoxicity in human umbilical vein endothelial cells (HUVECs).We demonstrated the protective effects of SME (1, 5, and 10 µg/mL) and its components against MGO-induced endotheli...
Source: Biological and Pharmaceutical Bulletin - November 4, 2021 Category: Drugs & Pharmacology Authors: Jae Sung Kim Jae Hyuk Lee Seong Min Hong KyoHee Cho Sun Yeou Kim Source Type: research

Machine Learning Prediction of the Three Main Input Parameters of a Simplified Physiologically Based Pharmacokinetic Model Subsequently Used to Generate Time-Dependent Plasma Concentration Data in Humans after Oral Doses of 212 Disparate Chemicals
Biol Pharm Bull. 2021 Nov 2. doi: 10.1248/bpb.b21-00769. Online ahead of print.ABSTRACTPhysiologically based pharmacokinetic (PBPK) modeling has the potential to play significant roles in estimating internal chemical exposures. The three major PBPK model input parameters (i.e., absorption rate constants, volumes of the systemic circulation, and hepatic intrinsic clearances) were generated in silico for 212 chemicals using machine learning algorithms. These input parameters were calculated based on sets of between 17 and 65 chemical properties that were generated by in silico prediction tools before being processed by machi...
Source: Biological and Pharmaceutical Bulletin - November 4, 2021 Category: Drugs & Pharmacology Authors: Yusuke Kamiya Kentaro Handa Tomonori Miura Junya Ohori Airi Kato Makiko Shimizu Masato Kitajima Hiroshi Yamazaki Source Type: research

Salvia miltiorrhiza prevents methylglyoxal-induced glucotoxicity via the regulation of apoptosis-related pathways and the glyoxalase system in human umbilical vein endothelial cells
Biol Pharm Bull. 2021 Nov 3. doi: 10.1248/bpb.b21-00507. Online ahead of print.ABSTRACTMethylglyoxal (MGO), which is produced as a byproduct of glucose metabolism, is the leading to diabetic cardiovascular complications. Salvia miltiorrhiza Bunge (Lamiaceae) has been reported as a potential plant to control diabetes and cardiovascular disease. However, no report exists on the effect of Salvia miltiorrhiza Bunge extract (SME) on MGO-induced glucotoxicity in human umbilical vein endothelial cells (HUVECs).We demonstrated the protective effects of SME (1, 5, and 10 µg/mL) and its components against MGO-induced endotheli...
Source: Biological and Pharmaceutical Bulletin - November 4, 2021 Category: Drugs & Pharmacology Authors: Jae Sung Kim Jae Hyuk Lee Seong Min Hong KyoHee Cho Sun Yeou Kim Source Type: research

Machine Learning Prediction of the Three Main Input Parameters of a Simplified Physiologically Based Pharmacokinetic Model Subsequently Used to Generate Time-Dependent Plasma Concentration Data in Humans after Oral Doses of 212 Disparate Chemicals
Biol Pharm Bull. 2021 Nov 2. doi: 10.1248/bpb.b21-00769. Online ahead of print.ABSTRACTPhysiologically based pharmacokinetic (PBPK) modeling has the potential to play significant roles in estimating internal chemical exposures. The three major PBPK model input parameters (i.e., absorption rate constants, volumes of the systemic circulation, and hepatic intrinsic clearances) were generated in silico for 212 chemicals using machine learning algorithms. These input parameters were calculated based on sets of between 17 and 65 chemical properties that were generated by in silico prediction tools before being processed by machi...
Source: Biological and Pharmaceutical Bulletin - November 4, 2021 Category: Drugs & Pharmacology Authors: Yusuke Kamiya Kentaro Handa Tomonori Miura Junya Ohori Airi Kato Makiko Shimizu Masato Kitajima Hiroshi Yamazaki Source Type: research

Salvia miltiorrhiza prevents methylglyoxal-induced glucotoxicity via the regulation of apoptosis-related pathways and the glyoxalase system in human umbilical vein endothelial cells
Biol Pharm Bull. 2021 Nov 3. doi: 10.1248/bpb.b21-00507. Online ahead of print.ABSTRACTMethylglyoxal (MGO), which is produced as a byproduct of glucose metabolism, is the leading to diabetic cardiovascular complications. Salvia miltiorrhiza Bunge (Lamiaceae) has been reported as a potential plant to control diabetes and cardiovascular disease. However, no report exists on the effect of Salvia miltiorrhiza Bunge extract (SME) on MGO-induced glucotoxicity in human umbilical vein endothelial cells (HUVECs).We demonstrated the protective effects of SME (1, 5, and 10 µg/mL) and its components against MGO-induced endotheli...
Source: Biological and Pharmaceutical Bulletin - November 4, 2021 Category: Drugs & Pharmacology Authors: Jae Sung Kim Jae Hyuk Lee Seong Min Hong KyoHee Cho Sun Yeou Kim Source Type: research

Machine Learning Prediction of the Three Main Input Parameters of a Simplified Physiologically Based Pharmacokinetic Model Subsequently Used to Generate Time-Dependent Plasma Concentration Data in Humans after Oral Doses of 212 Disparate Chemicals
Biol Pharm Bull. 2021 Nov 2. doi: 10.1248/bpb.b21-00769. Online ahead of print.ABSTRACTPhysiologically based pharmacokinetic (PBPK) modeling has the potential to play significant roles in estimating internal chemical exposures. The three major PBPK model input parameters (i.e., absorption rate constants, volumes of the systemic circulation, and hepatic intrinsic clearances) were generated in silico for 212 chemicals using machine learning algorithms. These input parameters were calculated based on sets of between 17 and 65 chemical properties that were generated by in silico prediction tools before being processed by machi...
Source: Biological and Pharmaceutical Bulletin - November 4, 2021 Category: Drugs & Pharmacology Authors: Yusuke Kamiya Kentaro Handa Tomonori Miura Junya Ohori Airi Kato Makiko Shimizu Masato Kitajima Hiroshi Yamazaki Source Type: research

Salvia miltiorrhiza prevents methylglyoxal-induced glucotoxicity via the regulation of apoptosis-related pathways and the glyoxalase system in human umbilical vein endothelial cells
Biol Pharm Bull. 2021 Nov 3. doi: 10.1248/bpb.b21-00507. Online ahead of print.ABSTRACTMethylglyoxal (MGO), which is produced as a byproduct of glucose metabolism, is the leading to diabetic cardiovascular complications. Salvia miltiorrhiza Bunge (Lamiaceae) has been reported as a potential plant to control diabetes and cardiovascular disease. However, no report exists on the effect of Salvia miltiorrhiza Bunge extract (SME) on MGO-induced glucotoxicity in human umbilical vein endothelial cells (HUVECs).We demonstrated the protective effects of SME (1, 5, and 10 µg/mL) and its components against MGO-induced endotheli...
Source: Biological and Pharmaceutical Bulletin - November 4, 2021 Category: Drugs & Pharmacology Authors: Jae Sung Kim Jae Hyuk Lee Seong Min Hong KyoHee Cho Sun Yeou Kim Source Type: research

Machine Learning Prediction of the Three Main Input Parameters of a Simplified Physiologically Based Pharmacokinetic Model Subsequently Used to Generate Time-Dependent Plasma Concentration Data in Humans after Oral Doses of 212 Disparate Chemicals
Biol Pharm Bull. 2021 Nov 2. doi: 10.1248/bpb.b21-00769. Online ahead of print.ABSTRACTPhysiologically based pharmacokinetic (PBPK) modeling has the potential to play significant roles in estimating internal chemical exposures. The three major PBPK model input parameters (i.e., absorption rate constants, volumes of the systemic circulation, and hepatic intrinsic clearances) were generated in silico for 212 chemicals using machine learning algorithms. These input parameters were calculated based on sets of between 17 and 65 chemical properties that were generated by in silico prediction tools before being processed by machi...
Source: Biological and Pharmaceutical Bulletin - November 4, 2021 Category: Drugs & Pharmacology Authors: Yusuke Kamiya Kentaro Handa Tomonori Miura Junya Ohori Airi Kato Makiko Shimizu Masato Kitajima Hiroshi Yamazaki Source Type: research

Salvia miltiorrhiza prevents methylglyoxal-induced glucotoxicity via the regulation of apoptosis-related pathways and the glyoxalase system in human umbilical vein endothelial cells
Biol Pharm Bull. 2021 Nov 3. doi: 10.1248/bpb.b21-00507. Online ahead of print.ABSTRACTMethylglyoxal (MGO), which is produced as a byproduct of glucose metabolism, is the leading to diabetic cardiovascular complications. Salvia miltiorrhiza Bunge (Lamiaceae) has been reported as a potential plant to control diabetes and cardiovascular disease. However, no report exists on the effect of Salvia miltiorrhiza Bunge extract (SME) on MGO-induced glucotoxicity in human umbilical vein endothelial cells (HUVECs).We demonstrated the protective effects of SME (1, 5, and 10 µg/mL) and its components against MGO-induced endotheli...
Source: Biological and Pharmaceutical Bulletin - November 4, 2021 Category: Drugs & Pharmacology Authors: Jae Sung Kim Jae Hyuk Lee Seong Min Hong KyoHee Cho Sun Yeou Kim Source Type: research

Application of Reverse Docking in the Research of Small Molecule Drugs and Traditional Chinese Medicine
Biol Pharm Bull. 2021 Oct 30. doi: 10.1248/bpb.b21-00324. Online ahead of print.ABSTRACTWith the development of structural biology and data mining, computer-aided drug design (CADD) has been playing an important role in all aspects of new drug development. Reverse docking, a method of virtual screening based on molecular docking in CADD, is widely used in drug repositioning, drug rescue, and traditional Chinese medicine (TCM) research, for it can search for macromolecular targets that can bind to a given ligand molecule. This review revealed the principle of reverse docking, summarized common target protein databases and d...
Source: Biological and Pharmaceutical Bulletin - November 1, 2021 Category: Drugs & Pharmacology Authors: Hongxu Wang Huiqin He Tingting Zhang Jingwei Jiang Source Type: research

Efficacy and safety of propranolol gel for infantile hemangioma: A randomized, double-blind study
Biol Pharm Bull. 2021 Oct 30. doi: 10.1248/bpb.b21-00500. Online ahead of print.ABSTRACTWe aimed to evaluate the efficacy and safety of propranolol gel at various concentrations with infantile hemangiomas after proliferative phases. We designed a single-center, randomized, double-blind, dose-dependent trial with placebo control and randomized patients to receive propranolol gel at 0%, 1%, or 5%, twice daily for 24 weeks. The primary efficacy endpoint was the percentage change in redness of the tumors. Safety endpoints were skin characteristics changes and systemic symptoms. We made two comparisons to evaluate the superiori...
Source: Biological and Pharmaceutical Bulletin - November 1, 2021 Category: Drugs & Pharmacology Authors: Naoaki Rikihisa Hirokazu Takatsuka Takaaki Suzuki Yuki Shiko Yohei Kawasaki Michiko Hanawa Itsuko Ishii Nobuyuki Mitsukawa Source Type: research

Indomethacin, a non-steroidal anti-inflammatory drug, induces skin dryness via PPAR γ in mice
In this study, the degree of skin dryness and the onset mechanism of this condition were investigated by comparing the effects of three non-steroidal anti-inflammatory drugs (NSAIDs) in mice. Mice were orally administered either indomethacin, loxoprofen sodium, or celecoxib (n = 5 per group) once daily for four consecutive days, and blood samples as well as skin and jejunal tissues were isolated on day 5. In the mice treated with indomethacin, transepidermal water loss was significantly increased, and dry skin was observed. In addition, the expression of matrix metalloproteinase (MMP)-I, mast cells, CD163, CD23, CD21, hist...
Source: Biological and Pharmaceutical Bulletin - November 1, 2021 Category: Drugs & Pharmacology Authors: Kiyoko Maruyama Kenji Goto Keiichi Hiramoto Shota Tanaka Kazuya Ooi Source Type: research

Chrono-Pharmaceutical Approaches to Optimize Dosing Regimens Based on the Circadian Clock Machinery
Biol Pharm Bull. 2021;44(11):1577-1584. doi: 10.1248/bpb.b21-00476.ABSTRACTDaily rhythmic variations in biological functions affect the efficacy and/or toxicity of drugs: a large number of drugs cannot be expected to exhibit the same potency at different administration times. The "circadian clock" is an endogenous timing system that broadly regulates metabolism, physiology and behavior. In mammals, this clock governs the oscillatory expression of the majority of genes with a period length of approximately 24 h. Genetic studies have revealed that molecular components of the circadian clock regulate the expression ...
Source: Biological and Pharmaceutical Bulletin - November 1, 2021 Category: Drugs & Pharmacology Authors: Satoru Koyanagi Source Type: research

Therapeutic Advantage of Tyk2 Inhibition for Treating Autoimmune and Chronic Inflammatory Diseases
Biol Pharm Bull. 2021;44(11):1585-1592. doi: 10.1248/bpb.b21-00609.ABSTRACTTyrosine kinase 2 (Tyk2) is a member of the Janus family of protein tyrosine kinases (Jaks). Tyk2 associates with interferon (IFN)-α, IFN-β, interleukin (IL)-6, IL-10, IL-12, and IL-23 receptors and mediates their downstream signaling pathways. Based on our data using Tyk2-deficient mice and cells, Tyk2 plays crucial roles in the differentiation, maintenance, and function of T helper 1 (Th1) and Th17 cells, and its dysregulation may promote autoimmune and/or inflammatory diseases. IFN-α-induced growth inhibition of B lymphocyte prog...
Source: Biological and Pharmaceutical Bulletin - November 1, 2021 Category: Drugs & Pharmacology Authors: Ryuta Muromoto Kazuya Shimoda Kenji Oritani Tadashi Matsuda Source Type: research

Foreword
Biol Pharm Bull. 2021;44(11):1593. doi: 10.1248/bpb.b21-ctf4411.NO ABSTRACTPMID:34719636 | DOI:10.1248/bpb.b21-ctf4411 (Source: Biological and Pharmaceutical Bulletin)
Source: Biological and Pharmaceutical Bulletin - November 1, 2021 Category: Drugs & Pharmacology Authors: Shuso Takeda Source Type: research

Estrogen Receptor β as a Possible Double-Edged Sword Molecule in Breast Cancer: A Mechanism of Alteration of Its Role by Exposure to Endocrine-Disrupting Chemicals
Biol Pharm Bull. 2021;44(11):1594-1597. doi: 10.1248/bpb.b21-00468.ABSTRACTEstrogen is essential for the growth and development of mammary glands and its signaling is associated with breast cancer growth. Estrogen can exert physiological actions via estrogen receptors α/β (ERα/β). There is experimental evidence suggesting that in ERα/β-positive breast cancer, ERα promotes tumor cell proliferation and ERβ inhibits ERα-mediated transcriptional activity, resulting in abrogation of cell growth. Therefore, ERβ is attracting attention as a potential tumor suppressor, and as ...
Source: Biological and Pharmaceutical Bulletin - November 1, 2021 Category: Drugs & Pharmacology Authors: Masayo Hirao-Suzuki Source Type: research

Targeting Peroxisome Proliferator-Activated Receptor- β/δ (PPARβ/δ) for the Treatment or Prevention of Alcoholic Liver Disease
Biol Pharm Bull. 2021;44(11):1598-1606. doi: 10.1248/bpb.b21-00486.ABSTRACTExcessive, chronic alcohol consumption can lead to alcoholic liver disease. The etiology of alcoholic liver disease is multifactorial and is influenced by alterations in gene expression and changes in fatty acid metabolism, oxidative stress, and insulin resistance. These events can lead to steatosis, fibrosis, and eventually to cirrhosis and liver cancer. Many of these functions are regulated by peroxisome proliferator-activated receptors (PPARs). Thus, it is not surprising that PPARs can modulate the mechanisms that cause alcoholic liver disease. W...
Source: Biological and Pharmaceutical Bulletin - November 1, 2021 Category: Drugs & Pharmacology Authors: Takayuki Koga Jeffrey M Peters Source Type: research

Identification of the ROR α Transcriptional Network Contributes to the Search for Therapeutic Targets in Atherosclerosis
Biol Pharm Bull. 2021;44(11):1607-1616. doi: 10.1248/bpb.b21-00426.ABSTRACTThe retinoic acid receptor-related orphan receptor α (RORα) is involved in the regulation of several physiological processes, including development, metabolism, and circadian rhythm. RORα-deficient mice display profound atherosclerosis, in which hypoalphalipoproteinemia is reportedly associated with decreased plasma levels of high-density lipoprotein, increased levels of inflammatory cytokines, and ischemia/reperfusion-induced damage. The recent characterization of endogenous ligands (including cholesterol, oxysterols, provitamin D...
Source: Biological and Pharmaceutical Bulletin - November 1, 2021 Category: Drugs & Pharmacology Authors: Hiroshi Matsuoka Akihiro Michihara Source Type: research

Variation in Expression of Cytochrome P450 3A Isoforms and Toxicological Effects: Endo- and Exogenous Substances as Regulatory Factors and Substrates
Biol Pharm Bull. 2021;44(11):1617-1634. doi: 10.1248/bpb.b21-00332.ABSTRACTThe CYP3A subfamily, which includes isoforms CYP3A4, CYP3A5, and CYP3A7 in humans, plays important roles in the metabolism of various endogenous and exogenous substances. Gene and protein expression of CYP3A4, CYP3A5, and CYP3A7 show large inter-individual differences, which are caused by many endogenous and exogenous factors. Inter-individual differences can cause negative outcomes, such as adverse drug events and disease development. Therefore, it is important to understand the variations in CYP3A expression caused by endo- and exogenous factors, ...
Source: Biological and Pharmaceutical Bulletin - November 1, 2021 Category: Drugs & Pharmacology Authors: Chieri Fujino Seigo Sanoh Toshiya Katsura Source Type: research

Functional Interaction between Cytochrome P450 and UDP-Glucuronosyltransferase on the Endoplasmic Reticulum Membrane: One of Post-translational Factors Which Possibly Contributes to Their Inter-Individual Differences
Biol Pharm Bull. 2021;44(11):1635-1644. doi: 10.1248/bpb.b21-00286.ABSTRACTCytochrome P450 (P450) and uridine 5'-diphosphate (UDP)-glucuronosyltransferase (UGT) catalyze oxidation and glucuronidation in drug metabolism, respectively. It is believed that P450 and UGT work separately because they perform distinct reactions and exhibit opposite membrane topologies on the endoplasmic reticulum (ER). However, given that some chemicals are sequentially metabolized by P450 and UGT, it is reasonable to consider that the enzymes may interact and work cooperatively. Previous research by our team detected protein-protein interactions...
Source: Biological and Pharmaceutical Bulletin - November 1, 2021 Category: Drugs & Pharmacology Authors: Yuu Miyauchi Shinji Takechi Yuji Ishii Source Type: research

TP0463518 (TS-143) Ameliorates Peptidoglycan-Polysaccharide Induced Anemia of Inflammation in Rats
In this study, we created a rat model of anemia of inflammation by administering peptidoglycan-polysaccharide (PG-PS) to Lewis rats; the PG-PS-treated rats developed anemia within 2 weeks after the PG-PS challenge. The hematopoietic effects of oral TP0463518 administration at 10 mg/kg once daily for 6 weeks were examined in this rat model. The hematocrit values in the TP0463518-treated group increased significantly from 32.8 ± 0.8 to 44.5 ± 2.1% after the treatment, which was comparable to that in the healthy control group. The change of the mean corpuscular volume following TP0463518 treatment was similar to...
Source: Biological and Pharmaceutical Bulletin - November 1, 2021 Category: Drugs & Pharmacology Authors: Sota Kato Koji Yamamoto Saeko Uchida Teisuke Takahashi Source Type: research

Neuroprotection by B355252 against Glutamate-Induced Cytotoxicity in Murine Hippocampal HT-22 Cells Is Associated with Activation of ERK3 Signaling Pathway
The objectives of this study were to further investigate the impact of B355252 on ERK3 and its downstream signaling pathways affected by glutamate exposure in the mouse hippocampal HT-22 neuronal cells. Murine hippocampal HT22 cells were incubated with glutamate and treated with B355252. Cell viability was assessed, protein levels of pERK3, ERK3, mitogen-activated protein kinase-activated protein kinase-5 (MAPKAPK-5), steroid receptor coactivator 3 (SRC-3), p-S6 and S6 were measured using Western blotting, and immunoreactivity of p-S6 was determined by immunocytochemistry. The results reveal that glutamate markedly diminis...
Source: Biological and Pharmaceutical Bulletin - November 1, 2021 Category: Drugs & Pharmacology Authors: Yanni Ma Qi Qi Qingping He Nailya S Gilyazova Gordon Ibeanu P Andy Li Source Type: research

Release of Nitrogen-Containing Bisphosphonates (NBPs) from Hydroxyapatite by Non-NBPs and by Pyrophosphate
Biol Pharm Bull. 2021;44(11):1670-1680. doi: 10.1248/bpb.b21-00320.ABSTRACTBisphosphonates (BPs) are major anti-bone-resorptive drugs. Among them, the nitrogen-containing BPs (NBPs) exhibit much stronger anti-bone-resorptive activities than non-nitrogen-containing BPs (non-NBPs). However, BP-related osteonecrosis of the jaw (BRONJ) has been increasing without effective strategies for its prevention or treatment. The release of NBPs (but not non-NBPs) from NBP-accumulated jawbones has been supposed to cause BRONJ, even though non-NBPs (such as etidronate (Eti) and clodronate (Clo)) are given at very high doses because of th...
Source: Biological and Pharmaceutical Bulletin - November 1, 2021 Category: Drugs & Pharmacology Authors: Kanan Bando Takefumi Oizumi Tetsu Takahashi Itaru Mizoguchi Shunji Sugawara Yasuo Endo Source Type: research

Temozolomide Induces Endocytosis of EGFRvIII via p38-Mediated Non-canonical Phosphorylation in Glioblastoma Cells
Biol Pharm Bull. 2021;44(11):1681-1687. doi: 10.1248/bpb.b21-00371.ABSTRACTThe ligand-induced internalization of epidermal growth factor receptor (EGFR) is generally considered to attenuate downstream signaling via its endosomal degradation. However, the endocytosis of an oncogenic EGFR variant III (EGFRvIII) is impaired, which leads to persistent signaling from the cell surface, thereby promoting the proliferation and survival of glioblastoma multiforme (GBM) cells. Cellular stress triggers the non-canonical endocytosis-recycling of EGFR by p38-mediated phosphorylation. In the present study, we used temozolomide (TMZ), th...
Source: Biological and Pharmaceutical Bulletin - November 1, 2021 Category: Drugs & Pharmacology Authors: Ratna Dini Haryuni Tomohiro Tanaka Jun-Ichiro Takahashi Iimi Onuma Yue Zhou Satoru Yokoyama Hiroaki Sakurai Source Type: research

Methylglyoxal-Derived Advanced Glycation End Products (AGE4) Promote Cell Proliferation and Survival in Renal Cell Carcinoma Cells through the RAGE/Akt/ERK Signaling Pathways
Biol Pharm Bull. 2021;44(11):1697-1706. doi: 10.1248/bpb.b21-00382.ABSTRACTAdvanced glycation end products (AGEs) are the products formed through a non-enzymatic reaction of reducing sugars with proteins or lipids. There is a potential for toxicity in the case of AGEs produced through glycation with dicarbonyl compounds including methylglyoxal, glyoxal, and 3-deoxyglucosone. The AGEs bind the receptor for advanced glycation end products (RAGE) and stimulate the mitogen-activated protein (MAP) kinase signaling pathway that can increase the production of matrix metalloproteinases (MMPs). In addition, AGE-induced protein kina...
Source: Biological and Pharmaceutical Bulletin - November 1, 2021 Category: Drugs & Pharmacology Authors: Han-Kyul Nam So-Ra Jeong Min Cheol Pyo Sang-Keun Ha Mi-Hyun Nam Kwang-Won Lee Source Type: research

Safety and Biocompatibility of Mupirocin Nanoparticle-Loaded Hydrogel on Burn Wound in Rat Model
This study focused on the safety of cell lines and the biocompatibility of MLH for wound healing in rat models. MLH was assessed by an analysis of cytotoxicity and the secretion of inflammatory cytokines in cell lines. The cytocompatibility of MLH was compared with mupirocin ointment on full-thickness burn wounds in rats. The results indicated that MLH and blank hydrogel had no toxicity to human epidermal keratinocytes and human fibroblast cells. MLH inhibited lipopolysaccharide (LPS) activity in macrophage-like cells resulting in low nitric oxide production and reduced inflammatory cytokine production (interleukin (IL)-1&...
Source: Biological and Pharmaceutical Bulletin - November 1, 2021 Category: Drugs & Pharmacology Authors: Sukanjana Kamlungmak Titpawan Nakpheng Sunisa Kaewpaiboon Muhammad Ali Khumaini Mudhar Bintang Supattra Prom-In Charisopon Chunhachaichana Tan Suwandecha Teerapol Srichana Source Type: research