Clinical characteristics and prognostic analysis of microscopic polyangiitis with diffuse alveolar haemorrhage.
Abstract OBJECTIVE: To analyse the clinical features and prognostic factors of microscopic polyangiitis (MPA) with diffuse alveolar haemorrhage (DAH). METHODS: We conducted a retrospective study of 92 patients diagnosed with MPA with DAH at the First Affiliated Hospital of Chongqing Medical University between March 1, 2012, and March 12, 2018. The cumulative survival rate was analyzed by the Kaplan-Meier method, and survival curves were drawn. A Cox hazard model was used to determine the prognostic factors for survival by univariate and multivariate analysis. RESULTS: The mean age at the onset of MPA wit...
Source: J Rheumatol - July 1, 2020 Category: Rheumatology Authors: Tang S, Li X, Zhao K, Zhou Q, Tang X Tags: J Rheumatol Source Type: research

"Unspoken Questions:" A Qualitative Study of Rheumatologists' Perspectives on the Clinical Implementation of Patient-Reported Outcome Measures.
CONCLUSION: Rheumatologists identified multiple mechanisms through which PROMs could augment clinical care, but also noted several obstacles to implementation, questioning the added value of PROMs and the limited availability of interventions to improve patient-centered outcomes. Programs seeking to successfully integrate PROMs to enhance patient-centered care and meet quality benchmarks should prioritize physician buy-in and training and provide resources to address the outcomes that are measured. PMID: 32611667 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - July 1, 2020 Category: Rheumatology Authors: Kasturi S, Wong JB, Mandl LA, McAlindon TE, LeClair A Tags: J Rheumatol Source Type: research

Cardiovascular risk scores in axial spondyloarthritis versus the general population: A cross-sectional study.
CONCLUSION: The prevalence of a 10-year ASCVD risk score ≥7.5% was not significantly different comparing axSpA patients and those drawn from the general population, who were similar in terms of age, sex, and race. Future studies should focus on improved CV risk prediction in axSpA, as underestimation by a general population risk score may potentially explain these results. PMID: 32611668 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - July 1, 2020 Category: Rheumatology Authors: Liew JW, Reveille JD, Castillo M, Sawhney H, Naovarat BS, Heckbert SR, Gensler LS Tags: J Rheumatol Source Type: research

Health Care Utilization and Costs of Systemic Lupus Erythematosus by Disease Severity in the United States.
CONCLUSION: US patients with SLE, especially individuals with moderate or severe disease, utilize significant health care resources and incur high medical costs. PMID: 32611669 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - July 1, 2020 Category: Rheumatology Authors: Murimi IB, Lin DH, Kan H, Tierce J, Wang X, Nab H, Desta B, Alexander GC, Hammond ER Tags: J Rheumatol Source Type: research

Angiotensin-converting enzyme 2, a SARS-CoV-2 receptor, is upregulated by interleukin-6 via STAT3 signaling in synovial tissues.
Abstract The severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) has spread explosively worldwide and resulted in a pandemic of a new respiratory disease called coronavirus disease 2019 (COVID-19) in 2020. Symptoms of COVID-19 include fever, malaise, cough, and in severe cases, pneumonia and acute respiratory distress syndrome (1,2). PMID: 32611670 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - July 1, 2020 Category: Rheumatology Authors: Mokuda S, Tokunaga T, Masumoto J, Sugiyama E Tags: J Rheumatol Source Type: research

Sex differences in the clinical profile among patients with gout: cross-sectional analyses of an observational study.
Abstract OBJECTIVE: Research findings in gout result predominantly from studies among men, and might not be generalizable to women. To improve insight into sex differences, this study compared clinical characteristics and comorbidities between female and male gout patients and explored the influence of menopausal state on these differences. METHODS: Data from patients referred to two rheumatology services and diagnosed with gout were used. Clinical characteristics and comorbidities between sexes were compared univariately. Sex difference in comorbidities were further explored in multivariable logistic regress...
Source: J Rheumatol - July 1, 2020 Category: Rheumatology Authors: Te Kampe R, Janssen M, van Durme C, Jansen TL, Boonen A Tags: J Rheumatol Source Type: research

Biomechanical properties of common carotid arteries assessed by circumferential two-dimensional strain and beta stiffness index in patients with ankylosing spondylitis.
qvist P Abstract OBJECTIVE: Ankylosing spondylitis (AS) is associated with an elevated risk of cardiovascular disease (CVD) related to atherosclerosis, preceded by arterial stiffness. We aimed to examine common carotid artery (CCA) biomechanical properties using ultrasound to calculate β stiffness index (indicating arterial stiffness) and, a more recently developed technique, two-dimensional (2D) speckle tracking strain (indicating arterial motion and deformation, strain) to 1) compare with age- and sex-matched controls and to 2) analyze relationships between strain and stiffness with disease characteristics ...
Source: J Rheumatol - July 1, 2020 Category: Rheumatology Authors: Forsblad-d'Elia H, Law L, Bengtsson K, Smeds J, Ketonen M, Sundström B, Ljung L, Geijer M, Söderberg S, Lindqvist P Tags: J Rheumatol Source Type: research

Effect of laser moxibustion for knee osteoarthritis: a multi-site double-blind randomized controlled trial.
Abstract OBJECTIVE: To examine the effects of laser moxibustion on pain and function in patients with knee osteoarthritis. METHODS: A double-blind randomized clinical trial (4-week treatment, 20-week follow-up) was conducted. A total of 392 symptomatic knee osteoarthritis patients with moderate or greater clinically significant knee pain were randomly assigned to laser treatment or sham laser control group (1:1). Twelve sessions of laser moxibustion treatments or sham on the acupuncture points at the affected knee(s) were performed three times a week for 4 weeks. The primary outcome measurement was change in ...
Source: J Rheumatol - July 1, 2020 Category: Rheumatology Authors: Zhao L, Cheng K, Wu F, Du J, Chen Y, Tan MT, Lao L, Shen X Tags: J Rheumatol Source Type: research

Propensity Score Methods in Rare Disease. A Demonstration Using Observational Data in Systemic Lupus Erythematosus.
Abstract Observational studies allow researchers to understand the natural history of rheumatic conditions, risk factors for disease development, factors affecting important disease-related outcomes and estimate treatment effect from real world data. However, this design carries a risk of confounding bias. A propensity score is a balancing score that aims to minimize the difference between study groups and consequently potential confounding effects. The score can be applied in one of four methods in observational research: matching, stratification, adjustment, and inverse probability weighting. Systemic lupus eryt...
Source: J Rheumatol - July 1, 2020 Category: Rheumatology Authors: Almaghlouth I, Pullenayegum E, Gladman DD, Urowitz MB, Johnson SR Tags: J Rheumatol Source Type: research

Enthesitis: Myth or Reality?
P, Faith N PMID: 32611772 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - July 1, 2020 Category: Rheumatology Authors: Bruyn G, HÁnovÁ P, Faith N Tags: J Rheumatol Source Type: research

Predicting Disease Activity in Systemic Vasculitides: On the Hunt for Potential Candidates.
PMID: 32611773 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - July 1, 2020 Category: Rheumatology Authors: Kronbichler A, Shin JI, Berti A Tags: J Rheumatol Source Type: research

Sweet Syndrome in Eosinophilic Granulomatosis with Polyangiitis.
PMID: 32611774 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - July 1, 2020 Category: Rheumatology Authors: Murphy K, Morrison L, McGOLDRICK J Tags: J Rheumatol Source Type: research

Higher Prevalence and Degree of Insulin Resistance in Patients with Rheumatoid Arthritis than in Patients with Systemic Lupus Erythematosus.
CONCLUSION: IR sensitivity is lower and beta cell function is higher in RA than in SLE patients. The fact that traditional IR factors have an equal effect on IR in both SLE and RA supports the contention that these differences are related to the diseases themselves. PMID: 32541071 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - June 15, 2020 Category: Rheumatology Authors: Quevedo-Abeledo JC, Sánchez-Pérez H, Tejera-Segura B, de Armas-Rillo L, Ojeda S, Erausquin C, González-Gay MÁ, Ferraz-Amaro I Tags: J Rheumatol Source Type: research

Disease Activity Score-28 using γGT Permits A Dual Evaluation Of Joint Activity And Cardiovascular Risk.
CONCLUSION: γGT may be considered as a marker of systemic inflammation and CV risk in RA patients. Based on these findings, we herein propose an original index, the DAS28-γGT, able to evaluate both joint disease activity and CV risk. This index will deserve further validation in prospective cohorts. PMID: 32541072 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - June 15, 2020 Category: Rheumatology Authors: Vergneault H, Vandebeuque E, Codullo V, Allanore Y, Avouac J Tags: J Rheumatol Source Type: research

Inflammatory Bowel Disease in Children with Systemic Juvenile Idiopathic Arthritis.
CONCLUSION: IBD in the setting of sJIA is a rare occurrence. The favorable response of sJIA symptoms to therapeutic TNF-α inhibition suggests that the sJIA-IBD cohort may represent a mechanistically distinct sJIA subgroup. Our study highlights the importance of maintaining a high level of suspicion for IBD when gastrointestinal involvement occurs in sJIA patients and the likely broad benefit of TNF-α inhibition in those cases. PMID: 32541073 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - June 15, 2020 Category: Rheumatology Authors: Maller J, Fox E, Park KT, Paul SS, Baszis K, Borocco C, Prahalad S, Quartier P, Reinhardt A, Schonenberg-Meinema D, Shipman L, Terreri MT, Simard J, Lavi I, Chalom E, Hsu J, Zisman D, Mellins ED, CARRA Legacy Registry Investigators Tags: J Rheumatol Source Type: research

Trends in the Inpatient Burden of Coronary Artery Disease in Granulomatosis with Polyangiitis: A Study of Large National Dataset.
CONCLUSION: In this national sample of GPA hospitalizations, we found that the burden of CAD and CAD with HF was on the rise over the 10-year period compared to non-GPA, however it was not the case for AMI. PMID: 32541074 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - June 15, 2020 Category: Rheumatology Authors: Luo Y, Xu J, Jiang C, Krittanawong C, Wu L, Yang Y, Bandyopadhyay D, Cram P, Ibrahim S, Mehta B Tags: J Rheumatol Source Type: research

Raynaud's phenomenon in Systemic Sclerosis: Does Digital Thermal Monitoring Correlate to Specific Nailfold Videocapillaroscopy Abnormalities?
In this study, we investigated the correlation of NVC patterns and DTM variables in SSc patients. METHODS: Patients with SSc by 2013 ACR/EULAR criteria that were consented into the clinical care registry had NVC and DTM performed. For NVC, the number of capillaries (density), measurement of apical diameter (dimension), presence or absence of hemorrhages and number of abnormal shapes were assessed to categorize three different qualitative patterns: 'early', 'active' and 'late'. For DTM, Doppler ultrasound hyperemic, low frequency, blood velocity of radial artery and fingertip vascular function was assessed and a vascul...
Source: J Rheumatol - June 15, 2020 Category: Rheumatology Authors: Thomas J, Radic M, Tucker JR, Overbury R, Frech T Tags: J Rheumatol Source Type: research

A Decline in Walking Speed is Associated with Incident Knee Replacement in Adults with and at Risk for Knee Osteoarthritis.
CONCLUSION: A one-year decline in walking speed is associated with an increased risk, while one-year increase in walking speed is associated with a decreased risk of future incident knee replacement. PMID: 32541076 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - June 15, 2020 Category: Rheumatology Authors: Harkey MS, Lapane KL, Liu SH, Lo GH, McAlindon TE, Driban JB Tags: J Rheumatol Source Type: research

Mixed airway and pulmonary parenchymal disease in patients with primary Sj ögren's Syndrome - a six-year follow-up.
CONCLUSION: Both airway and pulmonary parenchymal disease were commonly found in pSS patients, with a co-existence of both an obstructive and a restrictive pulmonary function pattern, where the latter tended to deteriorate over time. COPD was still a common finding. Airway and pulmonary involvement may be underdiagnosed in pSS, why special attention to clinical assessment of pulmonary involvement in pSS patients is mandated. PMID: 32541077 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - June 15, 2020 Category: Rheumatology Authors: Nilsson AM, Aaltonen HL, Olsson P, Persson HL, Hesselstrand R, Theander E, Wollmer P, Mandl T Tags: J Rheumatol Source Type: research

Whole-Body MRI in Psoriatic Arthritis, Rheumatoid Arthritis And Healthy Controls - Interscan, Intrareader and Interreader Agreement and Distribution of Lesions.
CONCLUSION: WBMRI showed good interscan agreement, implying that repositioning of the patient between examinations does not markedly affect scoring of lesions. Intra- and interreader agreement was moderate to almost perfect. PMID: 32541078 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - June 15, 2020 Category: Rheumatology Authors: Poulsen AE, Axelsen MB, Poggenborg RP, Eshed I, Krabbe S, Glinatsi D, Møller JM, Østergaard M Tags: J Rheumatol Source Type: research

Cerebellar Atrophy in Craniofacial Morphea: A Report of 2 Cases with 1-year Neuroimaging Followup.
We report 2 cases in which distant cerebellar lesions on brain MRI occurred with varying clinical neurologic manifestations. PMID: 32541079 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - June 15, 2020 Category: Rheumatology Authors: Lewinson RT, Prajapati VH, Luca NJ Tags: J Rheumatol Source Type: research

Proceedings of the 2019 Canadian Inflammatory Myopathy Study Symposium: Clinical Trial Readiness in Myositis.
Abstract The Canadian Inflammatory Myopathy Study (CIMS) is a multicenter prospective cohort recruiting in 8 centers across Canada. One of the aims of CIMS is to conduct and participate in clinical trials in autoimmune inflammatory myopathies (AIM). Conducting clinical trials in rare diseases such as AIM presents challenges. During this symposium, experts in the field presented different solutions to successfully conduct clinical trials in AIM, including the importance of collaboration and careful trial design, as well as training and mentoring of young investigators. PMID: 32541080 [PubMed - as supplied by ...
Source: J Rheumatol - June 15, 2020 Category: Rheumatology Authors: Leclair V, Landon-Cardinal O, Aggarwal R, Bansback N, Campbell C, Feldman BM, Jarry M, McNamara S, White B, Hudson M, CIMS Investigators Tags: J Rheumatol Source Type: research

The inverse OARSI-OMERACT criteria is a valid indicator of the clinical worsening of knee osteoarthritis: data from the Osteoarthritis Initiative.
CONCLUSION: The inverse OARSI-OMERACT criteria for worsening among people with KOA had good construct validity in relation to clinically relevant outcomes. PMID: 32541081 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - June 15, 2020 Category: Rheumatology Authors: Driban JB, Harkey MS, Price LL, Lo GH, McAlindon TE Tags: J Rheumatol Source Type: research

Circulating small non-coding RNA biomarkers of response to triple DMARD therapy in Caucasian women with early rheumatoid arthritis.
CONCLUSION: Pre-treatment levels of specific serum sncRNAs might facilitate identification of patients more likely to respond to triple DMARD therapy. PMID: 32541082 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - June 15, 2020 Category: Rheumatology Authors: Foers AD, Garnham AL, Smyth GK, Proudman SM, Cheng L, Hill AF, Pang KC, Wicks IP Tags: J Rheumatol Source Type: research

Teamwork, A Novel Concept During an Infectious Pandemic?
Abstract We value Drs. Caricchio's and Criner's appreciation of our commentary on the role of rheumatologists in the Covid-19 pandemic (1). We applaud Temple University for collaborating in the care of hospitalized patients with Covid-19, many of whom are suffering a cytokine storm syndrome (CSS) (2). PMID: 32513790 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - June 8, 2020 Category: Rheumatology Authors: Cron RQ, Chatham WW Tags: J Rheumatol Source Type: research

Rheumatologists and Pulmonologists at Temple University weather the COVID-19 storm together.
Abstract In recent commentaries from Lancet Rheumatology and The Journal of Rhuematology (1-2) the authors eloquently illustrated the connection between COVID-19 infection, the subsequent cytokine storm (CS) that ensues in a number of patients and the potential efficacy of biologics that Rheumatologists routinely use in their practices. Moreover those biologics were originally investigated by Rheumatologists for the treatment of numerous rheumatic conditions, including macrophage activating syndrome (MAS), a similar form of storm that resembles the one occurring in COVID-19 patients (3). PMID: 32513791 [PubMe...
Source: J Rheumatol - June 8, 2020 Category: Rheumatology Authors: Caricchio R, Criner GJ Tags: J Rheumatol Source Type: research

Canadian Rheumatology Association Meeting, Fairmont Empress, Victoria, British Columbia, Canada, February 26-29, 2020.
Abstract The 74th Annual Meeting of The Canadian Rheumatology Association was held at the Fairmont Empress, Victoria, British Columbia, Canada, February 26-29, 2020. The program consisted of presentations covering original research, symposia, awards, and lectures. PMID: 32482646 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - June 1, 2020 Category: Rheumatology Authors: Canadian Rheumatology Association Tags: J Rheumatol Source Type: research

Disease Characteristics, Quality of Life, and Work Productivity by Enthesitis Site: Real- World Data From the US Corrona Psoriatic Arthritis/Spondyloarthritis Registry.
CONCLUSION: Patients with clinical enthesitis had worse disease activity regardless of enthesitis location vs those without enthesitis, and patients with enthesitis in lower or both upper and lower sites had worse pain, fatigue, and work impairment. PMID: 32482647 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - June 1, 2020 Category: Rheumatology Authors: Mease PJ, Liu M, Rebello S, Hua W, McLean RR, Hur P, Ogdie A Tags: J Rheumatol Source Type: research

Case Report of Refractory Psoriatic Arthritis Achieving Remission Using Nigella sativa (Black Seed Oil) Extract.
Abstract Psoriatic arthritis (PsA) is one of the major extra skin manifestations of psoriasis and will develop in 20-30% of patients with psoriasis1 Alternative medicines, mainly herbal products, have been commonly used by patients for the treatment of psoriasis and there have been some studies into their efficacy, but most cases of PsA still require systemic therapy2. PMID: 32482648 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - June 1, 2020 Category: Rheumatology Authors: Rida MA, Gladman DD Tags: J Rheumatol Source Type: research

Association between centromere and topoisomerase specific immune responses and the degree of microangiopathy in Systemic Sclerosis.
CONCLUSION: We observed an association between ACA and ATA responses and the degree of microangiopathy in SSc. These findings might indicate that the breath of the autoimmune response as reflected by autoantibody production and microvascular damage interact in the pathophysiology of SSc. PMID: 32482649 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - June 1, 2020 Category: Rheumatology Authors: van Leeuwen NM, Wortel CM, Fehres CM, Bakker JA, Scherer HU, Toes REM, Huizinga TWJ, de Vries-Bouwstra JK Tags: J Rheumatol Source Type: research

Understanding the Biological Significance of Anti-DFS70 Antibodies: Effect of Biologic Therapies on Their Occurrence in Inflammatory Arthritis.
Abstract The anti-dense fine speckled 70 (anti-DFS70) antibodies have recently become of interest because of their occurring in heterogeneous disorders including chronic inflammatory conditions, cancer, and systemic autoimmune rheumatic diseases (SARD), as well as in healthy individuals1,2,3 The frequency of anti-DFS70 antibodies in rheumatoid arthritis (RA) ranged from 0 to 2.6%4. PMID: 32482650 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - June 1, 2020 Category: Rheumatology Authors: Carbone T, Esposito C, Pafundi V, Carriero A, Padula MC, Padula AA, D'Angelo S Tags: J Rheumatol Source Type: research

Antineoplastic Drug-induced Aortitis: An Unraveled Adverse Effect Using the World Health Organization Pharmacovigilance Database.
Abstract Aortitis is a rare inflammatory disease ranging from asymptomatic aortic thickening to life-threatening manifestations, especially aortic dissection or stenosis. Aortitis mainly occurs during systemic inflammatory diseases (giant cell arteritis, Takayasu arteritis, IgG4-related disease) and less frequently in patients with syphilis or tuberculosis1 Aortitis is rarely suspected to be induced by drugs and its causality is hardly assessable. The aim of our study is to identify drugs associated with aortitis occurrence using a data-mining approach. PMID: 32482651 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - June 1, 2020 Category: Rheumatology Authors: Mettler C, Chouchana L, Terrier B Tags: J Rheumatol Source Type: research

Is macrophage activation syndrome in Kawasaki disease underrecognized?
Abstract Kawasaki disease (KD) is an acute vasculitis of unknown etiology that predominantly affects children
Source: J Rheumatol - June 1, 2020 Category: Rheumatology Authors: Natoli V, Rosina S, Ravelli A Tags: J Rheumatol Source Type: research

No SLE with COVID-19 in Hong Kong: the effect of masking?
Abstract We read with interests the report by Favalli on the incidence of COVID-19 in Italian patients with connective tissue diseases [1]. None of the 61 patients with SLE surveyed was confirmed to have COVID-19. PMID: 32482653 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - June 1, 2020 Category: Rheumatology Authors: So H, Mak JWY, Tam LS Tags: J Rheumatol Source Type: research

Are patients with systemic lupus erythematosus at increased risk of severe COVID-19?
Abstract We thank So for the interest in our letter and for sharing the results about COVID-19 in patients with systemic lupus erythematosus (SLE) in Hong Kong (1). We agree that the quantification of the risk of infection with severe acute respiratory coronaviruses- 2 (SARS-CoV-2) in SLE patients is a major concern. PMID: 32482654 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - June 1, 2020 Category: Rheumatology Authors: Favalli EG, Agape E, Caporali R Tags: J Rheumatol Source Type: research

Systemic Treatment for Temporomandibular Joint Arthritis in Juvenile Idiopathic Arthritis.
PMID: 32482885 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - June 1, 2020 Category: Rheumatology Authors: Stoustrup P, Twilt M, Herlin T Tags: J Rheumatol Source Type: research

L5 Radiculopathy with Neurological Deficit Due To Sacral Insufficiency Fracture.
PMID: 32482886 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - June 1, 2020 Category: Rheumatology Authors: Toussirot E, Bereau M, Aubry S Tags: J Rheumatol Source Type: research

Dr. Balevic, et al, reply.
Abstract We read with great interest the very thoughtful commentary by Drs. Joob and Wiwanitkit. We agree with the authors that, despite conflicting clinical data to date, it is possible that HCQ may have a protective effect in the setting of COVID-19. More importantly, we agree that optimal HCQ dosage and timing is a critical underpinning for clinical trials. However, we highlight several considerations regarding treatment with high dose HCQ. PMID: 32451351 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - May 25, 2020 Category: Rheumatology Authors: Balevic SJ, Hornik CP, Green TP, Clowse MEB, Gonzalez D, Maharaj AR, Schanberg LE, Eudy AM, Swamy GK, Hughes BL, Cohen-Wolkowiez M Tags: J Rheumatol Source Type: research

SARS-CoV-2: Viral Mechanisms and Possible Therapeutic Targets - What to learn from Rheumatologists?
Abstract It was with great interest that we read the letter from Randy Cron and collaborators (1) linking the cytokine storm syndrome (CSS) seen in macrophage activation syndrome, common in the rheumatological setting, with the CSS postulated to be a background in the novel coronavirus (SARS-CoV-2) infection. Amid the high contagiousness of the virus, science was also infected by an infodemia, compelled to enter a race to find effective therapies studying mechanisms molecular aspects of SARS-CoV-2 concomitant to urgent bedside manage of patients. PMID: 32451352 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - May 25, 2020 Category: Rheumatology Authors: Mouraa CA, Cerqueira de Sant'Ana Costa AL Tags: J Rheumatol Source Type: research

Evidence of protective effect of hydroxychloroquine to prevent COVID-19.
Abstract We would like to share ideas on the report on "Hydroxychloroquine in Patients with Rheumatic Disease Complicated by COVID-19: Clarifying Target Exposures and the Need for Clinical Trials [1]."Balevic noted that "well-designed clinical trials that include patients with rheumatic disease are urgently needed to characterize the efficacy, safety, and target exposures for hydroxychloroquine [1]." PMID: 32451353 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - May 25, 2020 Category: Rheumatology Authors: Joob B, Wiwanitkit V Tags: J Rheumatol Source Type: research

Treating Covid-19 at the Inflection Point.
Abstract We appreciate the interest by Moura and colleague in our editorial regarding the role of the rheumatologist during the Covid-19 pandemic (1). The letter by Drs. Carlos Antonio Moura and Ana Luísa Cerqueira de Sant'Ana Costa emphasizes the need to understand mechanisms of disease underlying the more serious complications of Covid-19 infection as well as provide the best treatment possible to large numbers of seriously ill patients during a global pandemic (2). PMID: 32451354 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - May 25, 2020 Category: Rheumatology Authors: Chatham WW, Cron RQ Tags: J Rheumatol Source Type: research

COVID-19 and Rheumatology patients on immunomodulatory therapy - can we extrapolate data from previous viral pandemics?
Abstract The implications of COVID-19 are wide-ranging for specialties, like Rheumatology, where immunomodulatory therapies are prescribed, and there has been much trepidation amongst many healthcare professionals regarding the best course of management during this time. This pandemic has also left many national policy-makers perplexed due to our limited knowledge of the effects of COVID-19 in patients with rheumatic disease. Such limitations have resulted in variable evolving guidance amongst Rheumatologists around the globe. PMID: 32423974 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - May 18, 2020 Category: Rheumatology Authors: Jethwa H, Sullivan A, Abraham S Tags: J Rheumatol Source Type: research

The plight of patients with lupus nephritis in Wuhan, China.
Abstract The number of cases of SARS-CoV2 infection is rising rapidly globally. Severe disease and high fatality are observed in older patients and with comorbid conditions (1). PMID: 32385088 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - May 8, 2020 Category: Rheumatology Authors: Chen C, Yao B, Yan M, Su K, Wang H, Xu C Tags: J Rheumatol Source Type: research

Dr. Lubrano, et al reply.
Abstract We have read the letter of Dr. Scarpa1 Our editorial was written as a proposal for a different vision of psoriatic arthritis (PsA), a multifaceted syndrome, in the light of a better treatment stratification, and more in general, personalized medicine2. PMID: 32358153 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - May 1, 2020 Category: Rheumatology Authors: Lubrano E, Scriffignano S, Perrotta FM Tags: J Rheumatol Source Type: research

Flare rate thresholds for patient assessment of gout disease activity states.
CONCLUSION: Flares are significantly associated with perceptions of disease activity in gout and zero flares over the prior 6 or 12 months are necessary for most people to self-categorise as being in remission. However, recalled flare counts alone do not correctly classify all patients into selfcategorised disease activity states, suggesting that other factors may also contribute to selfperceived gout disease activity. PMID: 32358154 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - May 1, 2020 Category: Rheumatology Authors: Taylor W, Dalbeth N, Singh JA, Rahn EJ, Mudano AS, Chen YH, Lin CT, Tan P, Louthreno W, Vazquez-Mellado J, Hernández-Llinas H, Neogi T, Vargas-Santos AB, Castelar-Pinheiro G, Chaves-Amorim RB, Uhlig T, Hammer HB, Eliseev M, Perez-Ruiz F, Cavagna L, McCar Tags: J Rheumatol Source Type: research

Incidence and prevalence of juvenile systemic lupus erythematosus in Korea: data from the national health claims database 2017.
CONCLUSION: This Korean population-based epidemiological study of JSLE showed similar epidemiologic profiles to Asian population in other studies. The distribution of age, ethnicity, and pubertal status are important factors that influence population estimates of JSLE incidence and prevalence. PMID: 32358155 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - May 1, 2020 Category: Rheumatology Authors: Kwak SG, Par SH, Kim JY Tags: J Rheumatol Source Type: research

Ocular manifestations in rheumatoid arthritis, connective tissue disease and vasculitis: a systematic review and meta-analysis.
CONCLUSION: Eye involvement is present in approximately one fifth of rheumatoid arthritis patients, and one quarter to one third of patients with connective tissue diseases (other than Sjogren's syndrome at 90%) and vasculitis. PMID: 32358156 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - May 1, 2020 Category: Rheumatology Authors: Turk MA, Hayworth JL, Nevskaya T, Pope JE Tags: J Rheumatol Source Type: research

Are Salivary Gland Ultrasonography Scores Associated with Salivary Flow Rates and Oral Health Related Quality of Life in Sj ögren's syndrome?
Are Salivary Gland Ultrasonography Scores Associated with Salivary Flow Rates and Oral Health Related Quality of Life in Sjögren's syndrome? J Rheumatol. 2020 May 01;: Authors: Şahinkaya Y, Mumcu G, Özdemir FT, Kuruş RE, Ünal AU, Direskeneli H, Bruyn GA, Inanc N Abstract OBJECTIVE: Ultrasonography of major salivary glands (SGUS) is a widely used imaging technique to evaluate salivary gland involvement in primary Sjögren's syndrome (pSS). The aim of this study was to evaluate the relationship between SGUS, salivary flow rate (SFR) as an objective measure of the gland function and ...
Source: J Rheumatol - May 1, 2020 Category: Rheumatology Authors: Şahinkaya Y, Mumcu G, Özdemir FT, Kuruş RE, Ünal AU, Direskeneli H, Bruyn GA, Inanc N Tags: J Rheumatol Source Type: research

Evaluation of changes in skin and joint outcomes and associated treatment changes in PsA: Experience from the Corrona PsA/SpA Registry.
Abstract OBJECTIVE: To characterize skin severity and joint activity outcomes and associated treatment changes in patients with PsA through 12 months of follow-up after enrollment in the Corrona Psoriatic Arthritis/ Spondyloarthritis (PsA/SpA) Registry. METHODS: Patients ≥18 years of age with a diagnosis of PsA and a history of PsO between 3/21/13 and 9/30/16 were enrolled (n=647). Demographics, clinical features, and treatment characteristics were collected and stratified by skin severity and joint activity. Change in joint and skin from enrollment to the 12-month visit was classified by change in categor...
Source: J Rheumatol - May 1, 2020 Category: Rheumatology Authors: Mease PJ, Etzel CJ, Huster W, Armstrong A, Muram T, Lisse J, Rebello S, Dodge R, Murage MJ, Greenberg JD, Malatestinic W Tags: J Rheumatol Source Type: research

Psoriatic Syndrome or Psoriatic Disease?
Abstract I read with interest the editorial by Lubrano, et al 1 recently published in The Journal, and I fully agree with the authors about the clinical complexity usually provided by the natural course of psoriatic arthritis. Lubrano, et al expressed the idea that, when compared with the term psoriatic disease, that of psoriatic syndrome should better explain this complexity. PMID: 32358159 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - May 1, 2020 Category: Rheumatology Authors: Scarpa R Tags: J Rheumatol Source Type: research