DNA Methylation of the MHC Region in Rheumatoid Arthritis: Perspectives and Challenges.
PMID: 33139520 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - November 1, 2020 Category: Rheumatology Authors: Qiu W, Liu Y Tags: J Rheumatol Source Type: research

Treatment Continuation Guidance in Psoriatic Arthritis Clinical Care.
PMID: 33139521 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - November 1, 2020 Category: Rheumatology Authors: Orbai AM Tags: J Rheumatol Source Type: research

Comprehensive Care in Pediatric Rheumatic Diseases: A Multifaceted Challenge.
PMID: 33139522 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - November 1, 2020 Category: Rheumatology Authors: Gamwell KL, Hommel KA Tags: J Rheumatol Source Type: research

Hydroxychloroquine-induced Hyperpigmentation.
PMID: 33139523 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - November 1, 2020 Category: Rheumatology Authors: Bajoghli A, Hernandez G, Cardis MA Tags: J Rheumatol Source Type: research

Near Tetraploidy in a Patient with Systemic Lupus Erythematosus.
PMID: 33139524 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - November 1, 2020 Category: Rheumatology Authors: Zhang B, Chi H, Su Y Tags: J Rheumatol Source Type: research

Residual disease burden in axial Spondyloarthritis and Psoriatic Arthritis patients despite low disease activity states in a multi-ethnic Asian population.
Abstract OBJECTIVE: To evaluate the burden of residual disease in patients with axial SpondyloArthritis (axSpA) or Psoriatic Arthritis (PsA) who achieved low disease activity status. METHODS: We used baseline data from a clinic registry of SpA in a tertiary hospital in Singapore. For axSpA, LDA was defined as ASDAS-ESR
Source: J Rheumatol - November 1, 2020 Category: Rheumatology Authors: Liu V, Fong W, Kwan YH, Leung YY Tags: J Rheumatol Source Type: research

High frequency ultrasound assessment of systemic sclerosis skin involvement: intra-observer repeatability and relationship with clinician assessment and dermal collagen content.
CONCLUSION: Our data demonstrates excellent reproducibility and reassuring convergent validity with dermal collagen content. Detection of subclinical abnormalities is an additional benefit of HFUS. The observed correlations with collagen quantification support further investigation of HFUS as an alternative to mRSS in clinical trial settings. PMID: 33132218 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - November 1, 2020 Category: Rheumatology Authors: Flower VA, Barratt SL, Hart DJ, Mackenzie AB, Shipley JA, Ward SG, Pauling JD Tags: J Rheumatol Source Type: research

Circulating Fibroblast Growth Factor-21 Levels in Rheumatoid Arthritis: Associations with Disease Characteristics, Body Composition, and Physical Functioning.
CONCLUSION: FGF-21 levels are associated with obesity and inflammatory cytokines, and with worsening in physical functioning in RA. These data support the hypothesis that FGF-21 can identify patients at risk of functional decline. PMID: 33132219 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - November 1, 2020 Category: Rheumatology Authors: Gould PW, Zemel BS, Taratuta EG, Baker JF Tags: J Rheumatol Source Type: research

What it Means to Me to Have Juvenile Arthritis: One Patient's Definition.
Abstract I was diagnosed with juvenile arthritis at the age of two. Until recently, if you had asked me to describe my experience of arthritis, I might have told you about a cluster of symptoms: Having arthritis means I experience pain and swelling in my joints, have a particular set of elevated blood markers, and sometimes experience stiffness if I am in one position for a long time. PMID: 33132220 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - November 1, 2020 Category: Rheumatology Authors: Robertson AD Tags: J Rheumatol Source Type: research

Risk of Adverse Outcomes in Hospitalized Patients with Autoimmune Disease and COVID-19: A Matched Cohort Study from New York City.
Abstract OBJECTIVE: To examine the impact of autoimmune disease on the composite outcome of intensive care unit admission, intubation, or death, from COVID-19 in hospitalized patients. METHODS: Retrospective cohort study of 186 patients hospitalized with COVID-19 between March 1st-April 15th, 2020 at NewYork-Presbyterian Hospital/Columbia University Irving Medical Center. The cohort included 62 patients with autoimmune disease and 124 age- and sex-matched controls. The primary outcome was a composite of intensive care unit admission, intubation, and death, with secondary outcome assessing time to in-hospital ...
Source: J Rheumatol - November 1, 2020 Category: Rheumatology Authors: Faye AS, Lee KE, Laszkowska M, Kim J, Blackett JW, McKenney AS, Krigel A, Gile JT, Wang R, Bernstein EJ, Green PHR, Krishnareddy S, Hur C, Lebwohl B Tags: J Rheumatol Source Type: research

Famous Artists Who Suffer(ed) From Rheumatic Diseases: A Systematic Review.
Abstract Rheumatic diseases (RD) occur at a relatively high frequency in the population. We hypothesize that some of these diseases may have affected some artists and possibly influenced their works. In this article, a systematic review of all studies that described the occurrence of rheumatic diseases in famous artists in the world was performed. PMID: 33132222 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - November 1, 2020 Category: Rheumatology Authors: de Carvalho JF, da Silva FF, Ferreira de Andrade CA, Argolo JD, da Mota LMH Tags: J Rheumatol Source Type: research

Does Etanercept biosimilar prescription in a rheumatology center bend the medication cost curve?
EMM Abstract OBJECTIVE: The market entry of biosimilars is expected to bring budgetary relief. Our objective was to determine how the introduction of biosimilars influences medication cost in patients with rheumatoid arthritis and which patients gain access to biologicals due to the availability of biosimilars. METHODS: Using hospital data of patients with rheumatoid arthritis between 2014 and 2018, an interrupted time series was performed. The interruption in the time series was placed at June 2016, i.e., the introduction of the etanercept biosimilar. The changes in trends for rheumatic medication cost befor...
Source: J Rheumatol - November 1, 2020 Category: Rheumatology Authors: Müskens WD, Rongen-van Dartel SAA, van Riel PLCM, Adang EMM Tags: J Rheumatol Source Type: research

Soluble Low-density Lipoprotein Receptor-related Protein 1 in Juvenile Idiopathic Arthritis.
CONCLUSION: Plasma sLRP1 levels correlate with clinical and biomarker indicators of short-term improvement in JIA disease activity supporting sLRP1 as an upstream biomarker of potential utility for assessing JIA disease activity and outcome prediction. PMID: 33060303 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - October 15, 2020 Category: Rheumatology Authors: Rezaei E, Newkirk MM, Li Z, Gordon JR, Oen KG, Benseler SM, Boire G, Cabral DA, Campillo S, Chédeville G, Chetaille AL, Dancey P, Duffy C, Watanabe Duffy K, Houghton K, Huber AM, Jurencak R, Lang B, Morishita KA, Petty RE, Ramsey SE, Roth J, Schneider R, Tags: J Rheumatol Source Type: research

Giant cell arteritis and COVID-19: similarities and discriminators, a systematic literature review.
CONCLUSION: Overlapping features of GCA and COVID-19 include headache, fever, elevated CRP and cough. Jaw claudication, visual loss, platelet count and lymphocyte count may be more discriminatory. Physicians should be aware of the possibility of diagnostic confusion. We have designed a simple checklist to aid evidence-based evaluation of patients with suspected GCA. PMID: 33060304 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - October 15, 2020 Category: Rheumatology Authors: Mehta P, Sattui SE, van der Geest K, Brouwer E, Conway R, Putman MS, Robinson PC, Mackie SL Tags: J Rheumatol Source Type: research

Bioelectrical impedance vector analysis for nutritional status assessment in systemic sclerosis and association with disease characteristics.
Abstract OBJECTIVE: To use bioelectrical impedance vector analysis (BIVA) in a cohort of systemic sclerosis (SSc) patients in order to assess their nutritional status in comparison to other groups of patients and to find any correlation with clinical characteristics and outcome of the disease. METHODS: We retrospectively collected data from 50 SSc patients who underwent BIVA for clinical suspicion of malnutrition, and compared them with patients affected by other chronic autoimmune rheumatic diseases (OCAD, n.27) or only symptomatic (n.15), and with 50 healthy controls (HC). RESULTS: SSc patients present...
Source: J Rheumatol - October 15, 2020 Category: Rheumatology Authors: Di Battista M, Barsotti S, Monaco A, Rossi A, Della Rossa A, Mosca M Tags: J Rheumatol Source Type: research

Physical activity and attitudes towards exercise in people with axial and peripheral spondyloarthritis.
CONCLUSION: Participants with axial SpA had greater concerns regarding discomfort and injuries from exercise than those with peripheral SpA. Although no differences in time spent in vigorous activities were observed, participants with axial SpA spent less time than those with peripheral SpA in light to moderate activities. PMID: 33060306 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - October 15, 2020 Category: Rheumatology Authors: Liu SH, Shridharmurthy D, Lapane KL, Dubé CE, Gravallese EM, Kay J Tags: J Rheumatol Source Type: research

Association of Nail Psoriasis With Disease Activity Measures and Impact in Psoriatic Arthritis: Data From the Corrona Psoriatic Arthritis/Spondyloarthritis Registry.
Abstract OBJECTIVE: To examine the association of nail psoriasis with disease activity, quality of life, and work productivity in patients with psoriatic arthritis (PsA). METHODS: All patients with PsA who enrolled in the Corrona PsA/Spondyloarthritis Registry between March 2013 and October 2018 and had data on physician-reported nail psoriasis were included and stratified by presence vs absence of nail psoriasis at enrollment. Patient demographics, disease activity, quality of life, and work productivity at enrollment were compared between patients with vs without nail psoriasis using t-tests or Wilcoxon ran...
Source: J Rheumatol - October 15, 2020 Category: Rheumatology Authors: Mease PJ, Liu M, Rebello S, McLean RR, Dube B, Glynn M, Hur P, Ogdie A Tags: J Rheumatol Source Type: research

Dr. Elfishawi, et al reply.
We reported changes over time in gout presentation with podagra becoming less frequent, whereas hyperuricemia and chronic kidney disease were predictors of future flares2. PMID: 33060308 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - October 15, 2020 Category: Rheumatology Authors: Elfishawi MM, Crowson CS, Matteson EL, Bongartz T Tags: J Rheumatol Source Type: research

Benefits of Methotrexate Use on Cardiovascular Disease Risk among Rheumatoid Arthritis Patients Initiating Biologic Disease-Modifying Antirheumatic Drugs.
CONCLUSION: Among RA patients receiving biologics, concomitant methotrexate use was associated with a 24% lower risk for CVD events. PMID: 33060309 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - October 15, 2020 Category: Rheumatology Authors: Xie F, Chen L, Yun H, Levitan EB, Curtis JR Tags: J Rheumatol Source Type: research

Frequency of Allopurinol Dose Reduction in Hospitalized Patients With Gout Flares.
This study found 60% of the patients have at least 1 subsequent flare episode within 5 years of their initial gout diagnosis. PMID: 33060310 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - October 15, 2020 Category: Rheumatology Authors: Huang IJ, Bays AM, Liew JW Tags: J Rheumatol Source Type: research

The Effect of HLA-B27 on Susceptibility and Severity of Covid-19.
Abstract Although many genes have polymorphisms, major histocompatibility complex genes are the most polymorphic. Many assume that the diversity of HLA increases the likelihood that a species can survive pandemics. PMID: 33060311 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - October 15, 2020 Category: Rheumatology Authors: Rosenbaum JT, Hamilton H, Weisman MH, Reveille JD, Winthrop KL, Choi D Tags: J Rheumatol Source Type: research

Publication Trends in Rheumatology Systematic Reviews and Randomized Clinical Trials, 1995-2017.
Abstract The growth of systematic reviews and metaanalyses (SRMA) has outpaced the growth of randomized clinical trials (RCT) in many medicine subspecialties1 This may reflect technological advances in SRMA production, fewer barriers to publish, or academic pressure to produce citations2. PMID: 33060312 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - October 15, 2020 Category: Rheumatology Authors: Putman MS, Chaitoff A, Niforatos JD Tags: J Rheumatol Source Type: research

Drs. Dai and Felson reply.
Abstract We appreciate the interest and comments by Yang and Hung1 in our recent publication, "Sleep Quality Is Related to Worsening Knee Pain in Those with Widespread Pain: The Multicenter Osteoarthritis Study"2 Yang and Hung raised 3 issues about potential biases in the methodology in our study around (1) the assessment methods used for sleep quality, (2) confounding factors such as other pain medication used, and (3) the appropriateness of causality in the study conclusion1. PMID: 33060313 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - October 15, 2020 Category: Rheumatology Authors: Dai Z, Felson DT Tags: J Rheumatol Source Type: research

Relationship between Genetic Risk and Age of Diagnosis of Systemic Lupus Erythematosus.
CONCLUSION: Our data suggested that there is a linear relationship between genetic risk and age of SLE diagnosis and that HLA and non-HLA genetic risk scores are associated with age of diagnosis in opposite directions. PMID: 33060314 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - October 15, 2020 Category: Rheumatology Authors: Dominguez D, Kamphuis S, Beyene J, Wither J, Harley JB, Blanco I, Vila-Inda C, Brunner H, Klein-Gitleman M, McCurdy D, Wahezi DM, Lehman T, Jelusic M Tags: J Rheumatol Source Type: research

Upfront Combination Therapy With Rituximab and Mycophenolate Mofetil for Progressive Systemic Sclerosis.
Abstract Systemic sclerosis (SSc) is a complex disease involving multiple pathophysiological pathways: autoimmunity, vasculopathy, and fibrosis, all of which are interrelated. Most of the damage consists of skin and lung fibrosis, and is accumulated within the first 2 years of disease in rapidly progressive patients with a serology of anti-SCL-70 or anti-RNA polymerase III (RNAP3)1. PMID: 33060315 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - October 15, 2020 Category: Rheumatology Authors: Rimar D, Rosner I, Slobodin G Tags: J Rheumatol Source Type: research

A narrative review on measurement properties of fixed-distance walk tests up to 40 meters for adults with knee osteoarthritis.
Abstract Knee osteoarthritis (OA) is a serious disease and has no cure to date. Knee OA is a leading cause of functional limitation, e.g., difficulty walking. Walking speed is one method of quantifying difficulty with walking, and should be assessed in clinical practice for adults with knee OA because it has prognostic value and is modifiable. Specifically, slow walking speed is associated with increased risk of adverse health outcomes, including all-cause mortality in adults with knee OA and can be modified by engaging in physical activity or exercise. However, at present, there is little consensus on the distanc...
Source: J Rheumatol - October 15, 2020 Category: Rheumatology Authors: Master H, Coleman G, Dobson F, Bennell K, Hinman RS, Jakiela J, White DK Tags: J Rheumatol Source Type: research

Lupus Low Disease Activity State achievement is important for reducing adverse outcomes in pregnant patients with systemic lupus erythematosus.
CONCLUSION: Pregnant women with SLE have a higher risk of adverse pregnancy outcomes. Pregnancies are recommended to be delayed until achieving LLDAS and should be closely monitored with the lowest possible dose of corticosteroids. PMID: 33060317 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - October 15, 2020 Category: Rheumatology Authors: Kim JW, Jung JY, Kim HA, Yang JI, Kwak DW, Suh CH Tags: J Rheumatol Source Type: research

National Priorities for High Quality Rheumatology Transition Care for Youth in Canada.
CONCLUSION: We have identified priorities in education and advocacy for advancing transition care in Canada that require participation of pediatric and adult rheumatology providers, patients and arthritis stakeholders in the interest of advancing transition care outcomes. PMID: 33060318 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - October 15, 2020 Category: Rheumatology Authors: Barnabe C, Chomistek K, Luca N, Hazlewood G, Barber CEH, Steiman A, Stringer E Tags: J Rheumatol Source Type: research

Pulse Wave Velocity in Systemic Sclerosis: Potential Beneficial Effects of Bosentan on Forearm Arterial Stiffness? An Exploratory Study.
Abstract Treatment of digital ischemia in systemic sclerosis (SSc) remains a challenge. Although vasculopathy is generally thought to occur on a microvascular level, some observations suggest the involvement of medium-sized arteries as well. PMID: 33060319 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - October 15, 2020 Category: Rheumatology Authors: van Roon AM, Eman Abdulle A, Johannes Mulder D Tags: J Rheumatol Source Type: research

Bias in the Methodology: Sleep Quality Is Related to Worsening Knee Pain in Those With Widespread Pain.
Abstract We read with great interest the article in The Journal entitled, "Sleep Quality Is Related to Worsening Knee Pain in Those with Widespread Pain: The Multicenter Osteoarthritis Study" by Dai, et al 1 The authors reported the association between sleep quality and odds of developing knee pain, and how widespread pain modified this relationship. PMID: 33060320 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - October 15, 2020 Category: Rheumatology Authors: Yang CC, Hung PC Tags: J Rheumatol Source Type: research

Long-term Glucocorticoid Use in Rheumatoid Arthritis.
Abstract We read with interest the article by Hanly and Lethbridge concerning long-term patterns of glucocorticoid (GC) use in older patients with rheumatoid arthritis (RA)1 Their report indicates that GC use has remained relatively stable over time, in contrast to greater use of disease-modifying antirheumatic drugs and biologic agents in the treat-to-target directive. They also report that rheumatologists prescribe lower doses than other physicians, and that the mean dose for rheumatologists has decreased over time. PMID: 33060321 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - October 15, 2020 Category: Rheumatology Authors: Boers M, Pincus T Tags: J Rheumatol Source Type: research

Erectile Dysfunction in Men with Psoriatic Arthritis: A Population-based Cohort Study.
CONCLUSION: Men with PsA may have an increased risk of ED, which was detected, but likely underpowered in this study. Whether this difference is secondary to higher prevalence of traditional risk factors of ED in men with PsA compared to general population will require further study. PMID: 33060322 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - October 15, 2020 Category: Rheumatology Authors: Wilton KM, Achenbach SJ, Karmacharya P, Ernste FC, Matteson EL, Crowson CS Tags: J Rheumatol Source Type: research

The prevalence of Rheumatoid Arthritis: A systematic review of population-based studies.
CONCLUSION: The literature reports a wide range of point- and period- prevalence based on population forms and method of data collection, but average point- and period-prevalence of RA were 51/10,000 and 56/10,000, respectively. Higher urban vs rural prevalence may be biased by poor case finding with less health care or reflect risk environment. The population database studies were more consistent than sampling studies, and linked databases in different continents appeared to provide a consistent estimate of RA period-prevalence and confirming the high value of rheumatologist diagnosis as classification criteria. PMID...
Source: J Rheumatol - October 15, 2020 Category: Rheumatology Authors: Bander Almutairi K, Nossent JC, Preen DB, Keen HI, Inderjeeth CA Tags: J Rheumatol Source Type: research

Axial Spondyloarthritis Disease Activity Cutoffs at Golimumab Initiation in the French GO-PRACTICE Study: Parallels With the German GO-NICE Study.
Abstract Axial spondyloarthritis (axSpA) is a chronic inflammatory rheumatic disorder that includes both radiographic and nonradiographic entities1 International guidelines for axSpA management recommend nonsteroidal antiinflammatory drugs as the first line of treatment2,3. PMID: 33060324 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - October 15, 2020 Category: Rheumatology Authors: Goupille P, Harid N, Flipo RM Tags: J Rheumatol Source Type: research

Update on Sweet Syndrome in Eosinophilic Granulomatosis With Polyangiitis.
Abstract I read the article entitled, "Sweet Syndrome in Eosinophilic Granulomatosis with Polyangiitis," published in the July issue of The Journal 1, with great interest. However, it is important to mention concerns and issues with regard to investigations, diagnosis, differential diagnosis, and treatment of Sweet syndrome with vasculitis as presented by the authors. It is relevant to place these issues for the knowledge of the readers of this article. PMID: 33060325 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - October 15, 2020 Category: Rheumatology Authors: Agarwal S Tags: J Rheumatol Source Type: research

Rheumatoid Arthritis Known HLA Associations are Unlikely To Be Associated With Atopic Dermatitis.
Abstract Individuals with atopic dermatitis (AD) frequently have illnesses such as asthma and seasonal allergies. Recent studies have revealed associations between AD and rheumatoid arthritis (RA)1,2 For example, a study from Germany showed an increased risk of RA for those with AD (risk ratio 1.72, 95% CI 1.25-2.37). PMID: 33060326 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - October 15, 2020 Category: Rheumatology Authors: Margolis DJ, Mitra N, Monos DS Tags: J Rheumatol Source Type: research

It Is High Time That We Define Axial Psoriatic Arthritis.
PMID: 32873661 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - August 31, 2020 Category: Rheumatology Authors: Chandran V Tags: J Rheumatol Source Type: research

Lupus Nephritis and Chronic Kidney Disease.
PMID: 32873662 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - August 31, 2020 Category: Rheumatology Authors: Salama AD, Caplin B Tags: J Rheumatol Source Type: research

Miliary Histoplasmosis Mimicking Miliary Tuberculosis in a Patient Treated with Tumor Necrosis Factor- α Inhibitor Therapy.
Miliary Histoplasmosis Mimicking Miliary Tuberculosis in a Patient Treated with Tumor Necrosis Factor-α Inhibitor Therapy. J Rheumatol. 2020 Sep 01;47(9):1450-1451 Authors: GonzÁlez LA, GuzmÁn LC, MuÑoz-Vahos CH PMID: 32873663 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - August 31, 2020 Category: Rheumatology Authors: GonzÁlez LA, GuzmÁn LC, MuÑoz-Vahos CH Tags: J Rheumatol Source Type: research

Enthesitis: Myth or Reality?
Authors: PMID: 32873664 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - August 31, 2020 Category: Rheumatology Tags: J Rheumatol Source Type: research

Hospitalized Infections in People with Osteoarthritis: A National U.S. Study.
CONCLUSION: Serious infection rates have increased in people with osteoarthritis. Association of demographic, clinic and hospital variables with serious infection outcomes identifies potential targets for future interventions. PMID: 32739891 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - July 31, 2020 Category: Rheumatology Authors: Singh JA, Cleveland JD Tags: J Rheumatol Source Type: research

Outcomes Measured in Polymyalgia Rheumatica and Measurement Properties of Instruments Considered for the OMERACT Core Outcome Set: A Systematic Review.
CONCLUSION: Measurement of outcomes in studies of PMR lacks consistency. The critical patient-centred domain of physical function is poorly assessed. None of the candidate instruments considered for inclusion in the core outcome set had high quality evidence, derived from populations with PMR, on their full range of measurement properties. Further studies are needed to determine whether these instruments are suitable for inclusion in a Core Outcome Measurement set for PMR. PMID: 32739892 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - July 31, 2020 Category: Rheumatology Authors: Twohig H, Owen C, Muller S, Mallen C, Mitchell C, Hider S, Hill C, Shea B, Mackie S Tags: J Rheumatol Source Type: research

Impact on costs and quality-adjusted-life-years of treat-to-target treatment strategies initiating methotrexate, or tocilizumab, or their combination in early rheumatoid arthritis. 5 year economic evaluation.
CONCLUSION: Based on our analyses, early initiation of TCZ(+MTX), is not cost-effective compared to MTX initiation in a step-up treat-to-target treatment strategy over 5 years in early RA patients. PMID: 32739893 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - July 31, 2020 Category: Rheumatology Authors: Verhoeven MMA, Tekstra J, van Laar JM, Pethö-Schramm A, Borm MEA, Bijlsma JWJ, Jacobs JWG, Lafeber FPJG, Welsing PMJ Tags: J Rheumatol Source Type: research

Disease modifying anti-rheumatic drugs, biologics and corticosteroid use in older patients with rheumatoid arthritis over 20 years.
CONCLUSION: In older adults with RA the utilization of DMARDs and biologics has increased over the past 20 years. However, the use of corticosteroids has persisted. Renewed efforts are required to minimize their use in the long-term pharmacological management of RA. PMID: 32739894 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - July 31, 2020 Category: Rheumatology Authors: Hanly JG, Lethbridge L Tags: J Rheumatol Source Type: research

Maintaining Hepatitis B Protection in Immunocompromised Pediatric Rheumatology and Inflammatory Bowel Disease Patients.
CONCLUSION: Results of this study support the benefit of HBV screening in immunosuppressed patients. Beginning at age 11 years most patients lacked serologic immunity to HBV. Seroconversion for most patients 11-18 years occurred after one booster vaccine. Thus, for immunocompromised patients without recent HBV serologic data, obtaining the HBV serology beginning at age 11 years might be considered. Those 18 years and older were least likely to seroconvert after one booster, indicating that they may benefit from receiving the three-dose HBV vaccine series. PMID: 32739895 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - July 31, 2020 Category: Rheumatology Authors: Aljaberi N, Ghulam E, Smitherman EA, Favier L, Dykes DMH, Danziger-Isakov LA, Brady RC, Huggins J Tags: J Rheumatol Source Type: research

Effects of childhood-onset SLE on academic achievements and employment in adult life.
CONCLUSION: The effect of cSLE on academic achievements and employment is substantial, despite adjusting educational and vocational choices to the disease. Ongoing support, not only to help patients find suitable education and vocation, but also to offer guidance regarding potential adjustments during their career, is necessary to optimise participation in the community. PMID: 32739896 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - July 31, 2020 Category: Rheumatology Authors: Groot N, Kardolus A, Bijl M, Dolhain R, Teng O, Zirkzee E, de Leeuw K, Fritsch-Stork R, Burdorf L, Bultink I, Kamphuis S Tags: J Rheumatol Source Type: research

The effect of creatine supplementation on muscle function in childhood myositis: A randomized, double-blind, placebo-controlled feasibility study.
CONCLUSION: Creatine supplementation in children with JDM is feasible to study, and is safe and well-tolerated; it may lead to improvements in muscle metabolism. PMID: 32739897 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - July 31, 2020 Category: Rheumatology Authors: Dover S, Stephens S, Schneiderman JE, Pullenayegum E, Wells GD, Levy DM, Marcuz JA, Whitney K, Schulze A, Tein I, Feldman BM Tags: J Rheumatol Source Type: research

How Can We Improve the Use of Established Therapies in PsA?
PMID: 32739898 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - July 31, 2020 Category: Rheumatology Authors: Nash P Tags: J Rheumatol Source Type: research

APOL1 Gene - Implications for Systemic Lupus Erythematosus.
PMID: 32739899 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - July 31, 2020 Category: Rheumatology Authors: Hiraki LT Tags: J Rheumatol Source Type: research

Mixed Crystal Disease: A Tale of 2 Crystals.
PMID: 32739900 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - July 31, 2020 Category: Rheumatology Authors: Pascual E, Sivera F, Andres M Tags: J Rheumatol Source Type: research