Endothelial dysfunction in breast cancer survivors on aromatase inhibitors: changes over time

CONCLUSIONS: We hypothesize that long-term use of AI can lead to persistent endothelial dysfunction, and further investigation is necessary. In our study, patients were on AI for approximately 5-10 years. As a result, we do not have data on whether these changes, such as EndoPAT® ratio and the elasticity of small and large arterial, are reversible with discontinuation of AI. These findings set the stage for a larger study to more conclusively determine the association between AI exposure and cardiovascular outcomes. Further studies should evaluate for multivariate associations withmodifiable risk factors for CV disease.PMID:38693561 | DOI:10.1186/s40959-024-00227-z

Source: Atherosclerosis - May 1, 2024 Category: Cardiology Authors: Adnan Shaaban Ashley Petersen Heather Beckwith Natalia Florea David A Potter Douglas Yee Rachel I Vogel Daniel Duprez Anne H Blaes Source Type: research