Neutrophil-derived PAD4 induces citrullination of CKMT1 exacerbates mucosal inflammation in inflammatory bowel disease
In this study, we employed single-cell RNA sequencing (scRNA-seq) and substrate citrullination mapping to decipher the role of PAD4 in intestinal inflammation associated with IBD. Our results demonstrated that PAD4 deficiency alleviated colonic inflammation and restored intestinal barrier function in a dextran sulfate sodium (DSS)-induced colitis mouse model. scRNA-seq analysis revealed significant alterations in intestinal cell populations, with reduced neutrophil numbers and changes in epithelial subsets upon PAD4 deletion. Gene expression analysis highlighted pathways related to inflammation and epithelial cell function...
Source: Cellular and Molecular Immunology - May 8, 2024 Category: Molecular Biology Authors: Shuling Wang Yihang Song Zhijie Wang Xin Chang Haicong Wu Ziwei Yan Jiayi Wu Zixuan He Le Kang Wenjun Hu Tian Xia Zhaoshen Li Xingxing Ren Yu Bai Source Type: research
Distinct palmitoylation of Foxp3 regulates the function of regulatory T cells via palmitoyltransferases
Cell Mol Immunol. 2024 May 8. doi: 10.1038/s41423-024-01166-6. Online ahead of print.NO ABSTRACTPMID:38720064 | DOI:10.1038/s41423-024-01166-6 (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - May 8, 2024 Category: Molecular Biology Authors: Binhui Zhou Mengjie Zhang Haoyuan Ma Ying Wang Juanjuan Qiu Yang Liu Liaoxun Lu Tianhan Li Lichen Zhang Rong Huang Yanrong Gu Eryan Kong Yinming Liang Source Type: research
Immunopeptidome mining reveals a novel ERS-induced target in T1D
This study provides not only a new explanation for the role of ERS in promoting β-cell-targeted autoimmunity but also a potential target for the prevention and treatment of T1D. The data are available via ProteomeXchange with the identifier PXD041227.PMID:38689020 | DOI:10.1038/s41423-024-01150-0 (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - April 30, 2024 Category: Molecular Biology Authors: Lina Wang Shushu Yang Gaohui Zhu Jie Li Gang Meng Xiaoling Chen Mengjun Zhang Shufeng Wang Xiangqian Li Yu Pan Yi Huang Li Wang Yuzhang Wu Source Type: research
Immunopeptidome mining reveals a novel ERS-induced target in T1D
This study provides not only a new explanation for the role of ERS in promoting β-cell-targeted autoimmunity but also a potential target for the prevention and treatment of T1D. The data are available via ProteomeXchange with the identifier PXD041227.PMID:38689020 | DOI:10.1038/s41423-024-01150-0 (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - April 30, 2024 Category: Molecular Biology Authors: Lina Wang Shushu Yang Gaohui Zhu Jie Li Gang Meng Xiaoling Chen Mengjun Zhang Shufeng Wang Xiangqian Li Yu Pan Yi Huang Li Wang Yuzhang Wu Source Type: research
Immunopeptidome mining reveals a novel ERS-induced target in T1D
This study provides not only a new explanation for the role of ERS in promoting β-cell-targeted autoimmunity but also a potential target for the prevention and treatment of T1D. The data are available via ProteomeXchange with the identifier PXD041227.PMID:38689020 | DOI:10.1038/s41423-024-01150-0 (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - April 30, 2024 Category: Molecular Biology Authors: Lina Wang Shushu Yang Gaohui Zhu Jie Li Gang Meng Xiaoling Chen Mengjun Zhang Shufeng Wang Xiangqian Li Yu Pan Yi Huang Li Wang Yuzhang Wu Source Type: research
Immunopeptidome mining reveals a novel ERS-induced target in T1D
This study provides not only a new explanation for the role of ERS in promoting β-cell-targeted autoimmunity but also a potential target for the prevention and treatment of T1D. The data are available via ProteomeXchange with the identifier PXD041227.PMID:38689020 | DOI:10.1038/s41423-024-01150-0 (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - April 30, 2024 Category: Molecular Biology Authors: Lina Wang Shushu Yang Gaohui Zhu Jie Li Gang Meng Xiaoling Chen Mengjun Zhang Shufeng Wang Xiangqian Li Yu Pan Yi Huang Li Wang Yuzhang Wu Source Type: research
Immunopeptidome mining reveals a novel ERS-induced target in T1D
This study provides not only a new explanation for the role of ERS in promoting β-cell-targeted autoimmunity but also a potential target for the prevention and treatment of T1D. The data are available via ProteomeXchange with the identifier PXD041227.PMID:38689020 | DOI:10.1038/s41423-024-01150-0 (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - April 30, 2024 Category: Molecular Biology Authors: Lina Wang Shushu Yang Gaohui Zhu Jie Li Gang Meng Xiaoling Chen Mengjun Zhang Shufeng Wang Xiangqian Li Yu Pan Yi Huang Li Wang Yuzhang Wu Source Type: research
Immunopeptidome mining reveals a novel ERS-induced target in T1D
This study provides not only a new explanation for the role of ERS in promoting β-cell-targeted autoimmunity but also a potential target for the prevention and treatment of T1D. The data are available via ProteomeXchange with the identifier PXD041227.PMID:38689020 | DOI:10.1038/s41423-024-01150-0 (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - April 30, 2024 Category: Molecular Biology Authors: Lina Wang Shushu Yang Gaohui Zhu Jie Li Gang Meng Xiaoling Chen Mengjun Zhang Shufeng Wang Xiangqian Li Yu Pan Yi Huang Li Wang Yuzhang Wu Source Type: research
Tissue-specific features of innate lymphoid cells in antiviral defense
Cell Mol Immunol. 2024 Apr 29. doi: 10.1038/s41423-024-01161-x. Online ahead of print.ABSTRACTInnate lymphocytes (ILCs) rapidly respond to and protect against invading pathogens and cancer. ILCs include natural killer (NK) cells, ILC1s, ILC2s, ILC3s, and lymphoid tissue inducer (LTi) cells and include type I, type II, and type III immune cells. While NK cells have been well recognized for their role in antiviral immunity, other ILC subtypes are emerging as players in antiviral defense. Each ILC subset has specialized functions that uniquely impact the antiviral immunity and health of the host depending on the tissue microe...
Source: Cellular and Molecular Immunology - April 29, 2024 Category: Molecular Biology Authors: Sytse J Piersma Source Type: research
Tissue-specific features of innate lymphoid cells in antiviral defense
Cell Mol Immunol. 2024 Apr 29. doi: 10.1038/s41423-024-01161-x. Online ahead of print.ABSTRACTInnate lymphocytes (ILCs) rapidly respond to and protect against invading pathogens and cancer. ILCs include natural killer (NK) cells, ILC1s, ILC2s, ILC3s, and lymphoid tissue inducer (LTi) cells and include type I, type II, and type III immune cells. While NK cells have been well recognized for their role in antiviral immunity, other ILC subtypes are emerging as players in antiviral defense. Each ILC subset has specialized functions that uniquely impact the antiviral immunity and health of the host depending on the tissue microe...
Source: Cellular and Molecular Immunology - April 29, 2024 Category: Molecular Biology Authors: Sytse J Piersma Source Type: research
Inhibition of METTL3 in macrophages provides protection against intestinal inflammation
In this study, we discovered that increased expression of methyltransferase-like 3 (METTL3) in macrophages was correlated with the development of colitis and that depletion of METTL3 in macrophages protected mice against dextran sodium sulfate (DSS)-induced colitis. Mechanistic characterization indicated that METTL3 depletion increased the YTHDF3-mediated expression of phosphoglycolate phosphatase (PGP), which resulted in glucose metabolism reprogramming and the suppression of CD4+ T helper 1 (Th1) cell differentiation. Further analysis revealed that glucose metabolism contributed to the ability of METTL3 depletion to amel...
Source: Cellular and Molecular Immunology - April 22, 2024 Category: Molecular Biology Authors: Huilong Yin Zhuan Ju Xiang Zhang Wenjie Zuo Yuhang Yang Minhua Zheng Xiaofang Zhang Yuning Liu Yingran Peng Ying Xing Angang Yang Rui Zhang Source Type: research
Inhibition of METTL3 in macrophages provides protection against intestinal inflammation
In this study, we discovered that increased expression of methyltransferase-like 3 (METTL3) in macrophages was correlated with the development of colitis and that depletion of METTL3 in macrophages protected mice against dextran sodium sulfate (DSS)-induced colitis. Mechanistic characterization indicated that METTL3 depletion increased the YTHDF3-mediated expression of phosphoglycolate phosphatase (PGP), which resulted in glucose metabolism reprogramming and the suppression of CD4+ T helper 1 (Th1) cell differentiation. Further analysis revealed that glucose metabolism contributed to the ability of METTL3 depletion to amel...
Source: Cellular and Molecular Immunology - April 22, 2024 Category: Molecular Biology Authors: Huilong Yin Zhuan Ju Xiang Zhang Wenjie Zuo Yuhang Yang Minhua Zheng Xiaofang Zhang Yuning Liu Yingran Peng Ying Xing Angang Yang Rui Zhang Source Type: research
Inhibition of METTL3 in macrophages provides protection against intestinal inflammation
In this study, we discovered that increased expression of methyltransferase-like 3 (METTL3) in macrophages was correlated with the development of colitis and that depletion of METTL3 in macrophages protected mice against dextran sodium sulfate (DSS)-induced colitis. Mechanistic characterization indicated that METTL3 depletion increased the YTHDF3-mediated expression of phosphoglycolate phosphatase (PGP), which resulted in glucose metabolism reprogramming and the suppression of CD4+ T helper 1 (Th1) cell differentiation. Further analysis revealed that glucose metabolism contributed to the ability of METTL3 depletion to amel...
Source: Cellular and Molecular Immunology - April 22, 2024 Category: Molecular Biology Authors: Huilong Yin Zhuan Ju Xiang Zhang Wenjie Zuo Yuhang Yang Minhua Zheng Xiaofang Zhang Yuning Liu Yingran Peng Ying Xing Angang Yang Rui Zhang Source Type: research
Inhibition of METTL3 in macrophages provides protection against intestinal inflammation
In this study, we discovered that increased expression of methyltransferase-like 3 (METTL3) in macrophages was correlated with the development of colitis and that depletion of METTL3 in macrophages protected mice against dextran sodium sulfate (DSS)-induced colitis. Mechanistic characterization indicated that METTL3 depletion increased the YTHDF3-mediated expression of phosphoglycolate phosphatase (PGP), which resulted in glucose metabolism reprogramming and the suppression of CD4+ T helper 1 (Th1) cell differentiation. Further analysis revealed that glucose metabolism contributed to the ability of METTL3 depletion to amel...
Source: Cellular and Molecular Immunology - April 22, 2024 Category: Molecular Biology Authors: Huilong Yin Zhuan Ju Xiang Zhang Wenjie Zuo Yuhang Yang Minhua Zheng Xiaofang Zhang Yuning Liu Yingran Peng Ying Xing Angang Yang Rui Zhang Source Type: research
Inhibition of METTL3 in macrophages provides protection against intestinal inflammation
In this study, we discovered that increased expression of methyltransferase-like 3 (METTL3) in macrophages was correlated with the development of colitis and that depletion of METTL3 in macrophages protected mice against dextran sodium sulfate (DSS)-induced colitis. Mechanistic characterization indicated that METTL3 depletion increased the YTHDF3-mediated expression of phosphoglycolate phosphatase (PGP), which resulted in glucose metabolism reprogramming and the suppression of CD4+ T helper 1 (Th1) cell differentiation. Further analysis revealed that glucose metabolism contributed to the ability of METTL3 depletion to amel...
Source: Cellular and Molecular Immunology - April 22, 2024 Category: Molecular Biology Authors: Huilong Yin Zhuan Ju Xiang Zhang Wenjie Zuo Yuhang Yang Minhua Zheng Xiaofang Zhang Yuning Liu Yingran Peng Ying Xing Angang Yang Rui Zhang Source Type: research
