Implications of metabolism-driven myeloid dysfunctions in cancer therapy.
Abstract Immune homeostasis is maintained by an adequate balance of myeloid and lymphoid responses. In chronic inflammatory states, including cancer, this balance is lost due to dramatic expansion of myeloid progenitors that fail to mature to functional inflammatory neutrophils, macrophages, and dendritic cells (DCs), thus giving rise to a decline in the antitumor effector lymphoid response. Cancer-related inflammation orchestrates the production of hematopoietic growth factors and cytokines that perpetuate recruitment and activation of myeloid precursors, resulting in unresolved and chronic inflammation. This pat...
Source: Cellular and Molecular Immunology - October 19, 2020 Category: Molecular Biology Authors: Strauss L, Guarneri V, Gennari A, Sica A Tags: Cell Mol Immunol Source Type: research

Low-dose IL-2 therapy compensates for metabolic shifts and reverses anxiety-like behavior in PD-1 deficiency-induced autoimmunity.
PMID: 33067573 [PubMed - as supplied by publisher] (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - October 16, 2020 Category: Molecular Biology Authors: Lv C, Zhang H, Li Z, Zhang H, Zhang Y, Li R, Wei S, Yu D Tags: Cell Mol Immunol Source Type: research

Unique immunological profile in patients with COVID-19.
Abstract The relationship between severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and host immunity is poorly understood. We performed an extensive analysis of immune responses in 32 patients with severe COVID-19, some of whom succumbed. A control population of healthy subjects was included. Patients with COVID-19 had an altered distribution of peripheral blood lymphocytes, with an increased proportion of mature natural killer (NK) cells and low T-cell numbers. NK cells and CD8+ T cells overexpressed T-cell immunoglobulin and mucin domain-3 (TIM-3) and CD69. NK cell exhaustion was attested by increase...
Source: Cellular and Molecular Immunology - October 15, 2020 Category: Molecular Biology Authors: Varchetta S, Mele D, Oliviero B, Mantovani S, Ludovisi S, Cerino A, Bruno R, Castelli A, Mosconi M, Vecchia M, Roda S, Sachs M, Klersy C, Mondelli MU Tags: Cell Mol Immunol Source Type: research

Hepatic macrophages in liver homeostasis and diseases-diversity, plasticity and therapeutic opportunities.
Abstract Macrophages, which are key cellular components of the liver, have emerged as essential players in the maintenance of hepatic homeostasis and in injury and repair processes in acute and chronic liver diseases. Upon liver injury, resident Kupffer cells (KCs) sense disturbances in homeostasis, interact with hepatic cell populations and release chemokines to recruit circulating leukocytes, including monocytes, which subsequently differentiate into monocyte-derived macrophages (MoMϕs) in the liver. Both KCs and MoMϕs contribute to both the progression and resolution of tissue inflammation and injury in vario...
Source: Cellular and Molecular Immunology - October 12, 2020 Category: Molecular Biology Authors: Wen Y, Lambrecht J, Ju C, Tacke F Tags: Cell Mol Immunol Source Type: research

Innate lymphocytes: pathogenesis and therapeutic targets of liver diseases and cancer.
Abstract The liver is a lymphoid organ with unique immunological properties, particularly, its predominant innate immune system. The balance between immune tolerance and immune activity is critical to liver physiological functions and is responsible for the sensitivity of this organ to numerous diseases, including hepatotropic virus infection, alcoholic liver disease, nonalcoholic fatty liver disease, autoimmune liver disease, and liver cancer, which are major health problems globally. In the past decade, with the discovery of liver-resident natural killer cells, the importance of innate lymphocytes with tissue re...
Source: Cellular and Molecular Immunology - October 12, 2020 Category: Molecular Biology Authors: Chen Y, Tian Z Tags: Cell Mol Immunol Source Type: research

IL-33/ST2 signaling in liver transplantation.
PMID: 33041341 [PubMed - as supplied by publisher] (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - October 11, 2020 Category: Molecular Biology Authors: Tan Z, Sun B Tags: Cell Mol Immunol Source Type: research

Expression of leukotriene B4 receptor 1 defines functionally distinct DCs that control allergic skin inflammation.
Abstract Leukotriene B4 (LTB4) receptor 1 (BLT1) is a chemotactic G protein-coupled receptor expressed by leukocytes, such as granulocytes, macrophages, and activated T cells. Although there is growing evidence that BLT1 plays crucial roles in immune responses, its role in dendritic cells remains largely unknown. Here, we identified novel DC subsets defined by the expression of BLT1, namely, BLT1hi and BLT1lo DCs. We also found that BLT1hi and BLT1lo DCs differentially migrated toward LTB4 and CCL21, a lymph node-homing chemoattractant, respectively. By generating LTB4-producing enzyme LTA4H knockout mice and CD11...
Source: Cellular and Molecular Immunology - October 9, 2020 Category: Molecular Biology Authors: Koga T, Sasaki F, Saeki K, Tsuchiya S, Okuno T, Ohba M, Ichiki T, Iwamoto S, Uzawa H, Kitajima K, Meno C, Nakamura E, Tada N, Fukui Y, Kikuta J, Ishii M, Sugimoto Y, Nakao M, Yokomizo T Tags: Cell Mol Immunol Source Type: research

A compromised specific humoral immune response against the SARS-CoV-2 receptor-binding domain is related to viral persistence and periodic shedding in the gastrointestinal tract.
Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been redetected after discharge in some coronavirus disease 2019 (COVID-19) patients. The reason for the recurrent positivity of the test and the potential public health concern due to this occurrence are still unknown. Here, we analyzed the viral data and clinical manifestations of 289 domestic Chinese COVID-19 patients and found that 21 individuals (7.3%) were readmitted for hospitalization after detection of SARS-CoV-2 after discharge. First, we experimentally confirmed that the virus was involved in the initial infection and was not a se...
Source: Cellular and Molecular Immunology - October 9, 2020 Category: Molecular Biology Authors: Hu F, Chen F, Ou Z, Fan Q, Tan X, Wang Y, Pan Y, Ke B, Li L, Guan Y, Mo X, Wang J, Wang J, Luo C, Wen X, Li M, Ren P, Ke C, Li J, Lei C, Tang X, Li F Tags: Cell Mol Immunol Source Type: research

STING regulates BCR signaling in normal and malignant B cells.
Abstract STING is an endoplasmic reticulum (ER)-resident protein critical for sensing cytoplasmic DNA and promoting the production of type I interferons; however, the role of STING in B cell receptor (BCR) signaling remains unclear. We generated STING V154M knock-in mice and showed that B cells carrying constitutively activated STING specifically degraded membrane-bound IgM, Igα, and Igβ via SEL1L/HRD1-mediated ER-associated degradation (ERAD). B cells with activated STING were thus less capable of responding to BCR activation by phosphorylating Igα and Syk than those without activated STING. When...
Source: Cellular and Molecular Immunology - September 29, 2020 Category: Molecular Biology Authors: Tang CA, Lee AC, Chang S, Xu Q, Shao A, Lo Y, Spalek WT, Pinilla-Ibarz JA, Del Valle JR, Hu CA Tags: Cell Mol Immunol Source Type: research

Transcription tipping points for T follicular helper cell and T-helper 1 cell fate commitment.
Abstract During viral infection, immune cells coordinate the induction of inflammatory responses that clear infection and humoral responses that promote protection. CD4+ T-cell differentiation sits at the center of this axis. Differentiation toward T-helper 1 (Th1) cells mediates inflammation and pathogen clearance, while T follicular helper (Tfh) cells facilitate germinal center (GC) reactions for the generation of high-affinity antibodies and immune memory. While Th1 and Tfh differentiation occurs in parallel, these CD4+ T-cell identities are mutually exclusive, and progression toward these ends is determined vi...
Source: Cellular and Molecular Immunology - September 29, 2020 Category: Molecular Biology Authors: Sheikh AA, Groom JR Tags: Cell Mol Immunol Source Type: research

Clinical development of CAR T cell therapy in China: 2020 update.
Abstract Chimeric antigen receptor (CAR) T-cell therapy has achieved significant success in the treatment of hematological malignancies. In recent years, fast-growing CAR T clinical trials have actively explored their potential application scenarios. According to the data from the clinicaltrials.gov website, China became the country with the most registered CAR T trials in September 2017. As of June 30, 2020, the number of registered CAR T trials in China has reached 357. In addition, as many as 150 other CAR T trials have been registered on ChiCTR. Although CAR T therapy is flourishing in China, there are still s...
Source: Cellular and Molecular Immunology - September 29, 2020 Category: Molecular Biology Authors: Wei J, Guo Y, Wang Y, Wu Z, Bo J, Zhang B, Zhu J, Han W Tags: Cell Mol Immunol Source Type: research

Vitamin C as a promoter of γδ T cells.
Vitamin C as a promoter of γδ T cells. Cell Mol Immunol. 2020 Sep 30;: Authors: Meraviglia S, Dieli F PMID: 32999456 [PubMed - as supplied by publisher] (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - September 29, 2020 Category: Molecular Biology Authors: Meraviglia S, Dieli F Tags: Cell Mol Immunol Source Type: research

A shedding  soluble form of interleukin-17 receptor D exacerbates collagen-induced arthritis through facilitating TNF-α-dependent receptor clustering.
A shedding soluble form of interleukin-17 receptor D exacerbates collagen-induced arthritis through facilitating TNF-α-dependent receptor clustering. Cell Mol Immunol. 2020 Sep 22;: Authors: Liu S, Fu Y, Mei K, Jiang Y, Sun X, Wang Y, Ren F, Jiang C, Meng L, Lu S, Qin Z, Dong C, Wang X, Chang Z, Yang S Abstract Rheumatoid arthritis (RA) is exacerbated by TNF-alpha signaling. However, it remains unclear whether TNF-α-activated TNFR1 and TNFR2 are regulated by extracellular factors. Here, we showed that soluble glycosylated interleukin-17 receptor D (sIL-17RD), which was produced b...
Source: Cellular and Molecular Immunology - September 21, 2020 Category: Molecular Biology Authors: Liu S, Fu Y, Mei K, Jiang Y, Sun X, Wang Y, Ren F, Jiang C, Meng L, Lu S, Qin Z, Dong C, Wang X, Chang Z, Yang S Tags: Cell Mol Immunol Source Type: research

The innate immune effector ISG12a promotes cancer immunity by suppressing the canonical Wnt/ β-catenin signaling pathway.
This study reveals a mechanism underlying the anticancer effects of IFN. Some ISGs, as represented by ISG12a, may be useful in cancer therapy and prevention. The identified interrelations among innate immunity, Wnt/β-catenin signaling, and cancer immunity may provide new insight into strategies that will improve the efficiency of immunotherapy. PMID: 32963356 [PubMed - as supplied by publisher] (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - September 21, 2020 Category: Molecular Biology Authors: Deng R, Zuo C, Li Y, Xue B, Xun Z, Guo Y, Wang X, Xu Y, Tian R, Chen S, Liu Q, Chen J, Wang J, Huang X, Li H, Guo M, Wang X, Yang M, Wu Z, Wang J, Ma J, Hu J, Li G, Tang S, Tu Z, Ji H, Zhu H Tags: Cell Mol Immunol Source Type: research

Serum inflammatory factors are positively correlated with the production of specific antibodies in coronavirus disease 2019 patients.
PMID: 32963357 [PubMed - as supplied by publisher] (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - September 21, 2020 Category: Molecular Biology Authors: Zheng M, Gao Y, Liu S, Sun D, Yang F, Zong L, Zhang M, Tian Z, Xu Y, Sun H Tags: Cell Mol Immunol Source Type: research

Liver X receptor β is required for the survival of single-positive thymocytes by regulating IL-7Rα expression.
Liver X receptor β is required for the survival of single-positive thymocytes by regulating IL-7Rα expression. Cell Mol Immunol. 2020 Sep 22;: Authors: Huang H, Wu X, Meng D, Feng Y, Zhou L, Liu Z, Tang S, Li X, Cao Y, He H, Xie Z, Zhang J, Chen Y, Zhao T, Wu Y, Zhou X Abstract Liver X receptors (LXRs) are known as key transcription factors in lipid metabolism and have been reported to play an important role in T-cell proliferation. However, whether LXRs play a role in thymocyte development remains largely unknown. Here, we demonstrated that LXRβ deficiency caused a reduction in single...
Source: Cellular and Molecular Immunology - September 21, 2020 Category: Molecular Biology Authors: Huang H, Wu X, Meng D, Feng Y, Zhou L, Liu Z, Tang S, Li X, Cao Y, He H, Xie Z, Zhang J, Chen Y, Zhao T, Wu Y, Zhou X Tags: Cell Mol Immunol Source Type: research

Allogeneic V γ9Vδ2 T-cell immunotherapy exhibits promising clinical safety and prolongs the survival of patients with late-stage lung or liver cancer.
Allogeneic Vγ9Vδ2 T-cell immunotherapy exhibits promising clinical safety and prolongs the survival of patients with late-stage lung or liver cancer. Cell Mol Immunol. 2020 Sep 16;: Authors: Xu Y, Xiang Z, Alnaggar M, Kouakanou L, Li J, He J, Yang J, Hu Y, Chen Y, Lin L, Hao J, Li J, Chen J, Li M, Wu Q, Peters C, Zhou Q, Li J, Liang Y, Wang X, Han B, Ma M, Kabelitz D, Xu K, Tu W, Wu Y, Yin Z Abstract Vγ9Vδ2 T cells are promising candidates for cellular tumor immunotherapy. Due to their HLA-independent mode of action, allogeneic Vγ9Vδ2 T cells can be considered for c...
Source: Cellular and Molecular Immunology - September 15, 2020 Category: Molecular Biology Authors: Xu Y, Xiang Z, Alnaggar M, Kouakanou L, Li J, He J, Yang J, Hu Y, Chen Y, Lin L, Hao J, Li J, Chen J, Li M, Wu Q, Peters C, Zhou Q, Li J, Liang Y, Wang X, Han B, Ma M, Kabelitz D, Xu K, Tu W, Wu Y, Yin Z Tags: Cell Mol Immunol Source Type: research

Recovered COVID-19 patients with recurrent viral RNA exhibit lower levels of anti-RBD antibodies.
PMID: 32939033 [PubMed - as supplied by publisher] (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - September 15, 2020 Category: Molecular Biology Authors: Liu B, Shi Y, Zhang W, Li R, He Z, Yang X, Pan Y, Deng X, Tan M, Zhao L, Zou F, Zhang Y, Pan T, Zhang J, Zhang X, Xiao F, Li F, Deng K, Zhang H Tags: Cell Mol Immunol Source Type: research

Macrophages and the maintenance of homeostasis.
Abstract There have been many chapters written about macrophage polarization. These chapters generally focus on the role of macrophages in orchestrating immune responses by highlighting the T-cell-derived cytokines that shape these polarizing responses. This bias toward immunity is understandable, given the importance of macrophages to host defense. However, macrophages are ubiquitous and are involved in many different cellular processes, and describing them as immune cells is undoubtedly an oversimplification. It disregards their important roles in development, tissue remodeling, wound healing, angiogenesis, and ...
Source: Cellular and Molecular Immunology - September 14, 2020 Category: Molecular Biology Authors: Mosser DM, Hamidzadeh K, Goncalves R Tags: Cell Mol Immunol Source Type: research

IL-17 sustains the plasma cell response via p38-mediated Bcl-xL RNA stability in lupus pathogenesis.
In this study, we first found that a major subset of IL-17 receptor-expressing plasma cells potently produced anti-dsDNA IgG upon IL-17A (IL-17) stimulation in SLE patients and lupus mice. Using a humanized lupus mouse model, we showed that the transfer of Th17 cell-depleted PBMCs from lupus patients resulted in a significantly reduced plasma cell response and attenuated renal damage in recipient mice compared to the transfer of total SLE PBMCs. Moreover, long-term BrdU incorporation in lupus mice detected highly enriched long-lived BrdU+ subsets among IL-17 receptor-expressing plasma cells. Lupus mice deficient in IL-17 o...
Source: Cellular and Molecular Immunology - September 10, 2020 Category: Molecular Biology Authors: Ma K, Du W, Xiao F, Han M, Huang E, Peng N, Tang Y, Deng C, Liu L, Chen Y, Li J, Yuan S, Huang Q, Hong X, Hu D, Cai X, Jiang Q, Liu D, Lu L Tags: Cell Mol Immunol Source Type: research

Low glycosylated ferritin is a sensitive biomarker of severe COVID-19.
oux Y PMID: 32917980 [PubMed - as supplied by publisher] (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - September 10, 2020 Category: Molecular Biology Authors: Fauter M, Viel S, Zaepfel S, Pradat P, Fiscus J, Villard M, Garnier L, Walzer T, Sève P, Henry T, Jamilloux Y Tags: Cell Mol Immunol Source Type: research

Direct interaction between CD155 and CD96 promotes immunosuppression in lung adenocarcinoma.
PMID: 32917981 [PubMed - as supplied by publisher] (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - September 10, 2020 Category: Molecular Biology Authors: Zhang H, Liu Q, Lei Y, Zhou J, Jiang W, Cui Y, He Q, Zhu J, Zhu Z, Sun Y, Ke Z Tags: Cell Mol Immunol Source Type: research

Synthetic vitamin K analogs inhibit inflammation by targeting the NLRP3 inflammasome.
Abstract Vitamin K refers to a group of structurally similar vitamins that are essential for proper blood coagulation, as well as bone and cardiovascular health. Previous studies have indicated that vitamin K may also have anti-inflammatory properties, although the underlying mechanisms of its anti-inflammatory effects remain unclear. The NLRP3 inflammasome is a multiprotein complex, and its activation leads to IL-1β and IL-18 secretion and contributes to the pathogenesis of various human inflammatory diseases. Here, we show that synthetic vitamins K3 and K4 are selective, potent inhibitors of the NLRP3 infla...
Source: Cellular and Molecular Immunology - September 10, 2020 Category: Molecular Biology Authors: Zheng X, Hou Y, He H, Chen Y, Zhou R, Wang X, Gong T, Jiang W Tags: Cell Mol Immunol Source Type: research

Sepsis-associated severe interleukin-6 storm in critical coronavirus disease 2019.
PMID: 32917983 [PubMed - as supplied by publisher] (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - September 10, 2020 Category: Molecular Biology Authors: Huang L, Zhao X, Qi Y, Li H, Ye G, Liu Y, Zhang Y, Gou J Tags: Cell Mol Immunol Source Type: research

Kidney GATA3+ regulatory T cells play roles in the convalescence stage after antibody-mediated renal injury.
Abstract FoxP3+ regulatory T cells (Tregs) play crucial roles in peripheral immune tolerance. In addition, Tregs that reside or accumulate in nonlymphoid tissues, called tissue Tregs, exhibit tissue-specific functions and contribute to the maintenance of tissue homeostasis and repair. In an experimental mouse model of crescentic glomerulonephritis induced by an anti-glomerular basement membrane antibody, Tregs started to accumulate in the kidney on day 10 of disease onset and remained at high levels (~30-35% of CD4+ T cells) during the late stage (days 21-90), which correlated with stable disease control. Treg dep...
Source: Cellular and Molecular Immunology - September 10, 2020 Category: Molecular Biology Authors: Sakai R, Ito M, Komai K, Iizuka-Koga M, Matsuo K, Nakayama T, Yoshie O, Amano K, Nishimasu H, Nureki O, Kubo M, Yoshimura A Tags: Cell Mol Immunol Source Type: research

The inhibitor effect of RKIP on inflammasome activation and inflammasome-dependent diseases.
Abstract Aberrant inflammasome activation contributes to the pathogenesis of various human diseases, including atherosclerosis, gout, and metabolic disorders. Elucidation of the underlying mechanism involved in the negative regulation of the inflammasome is important for developing new therapeutic targets for these diseases. Here, we showed that Raf kinase inhibitor protein (RKIP) negatively regulates the activation of the NLRP1, NLRP3, and NLRC4 inflammasomes. RKIP deficiency enhanced caspase-1 activation and IL-1β secretion via NLRP1, NLRP3, and NLRC4 inflammasome activation in primary macrophages. The over...
Source: Cellular and Molecular Immunology - September 7, 2020 Category: Molecular Biology Authors: Qin Q, Liu H, Shou J, Jiang Y, Yu H, Wang X Tags: Cell Mol Immunol Source Type: research

Phages and their potential to modulate the microbiome and immunity.
Abstract Bacteriophages (hence termed phages) are viruses that target bacteria and have long been considered as potential future treatments against antibiotic-resistant bacterial infection. However, the molecular nature of phage interactions with bacteria and the human host has remained elusive for decades, limiting their therapeutic application. While many phages and their functional repertoires remain unknown, the advent of next-generation sequencing has increasingly enabled researchers to decode new lytic and lysogenic mechanisms by which they attack and destroy bacteria. Furthermore, the last decade has witnes...
Source: Cellular and Molecular Immunology - September 7, 2020 Category: Molecular Biology Authors: Federici S, Nobs SP, Elinav E Tags: Cell Mol Immunol Source Type: research

Linear epitopes of SARS-CoV-2 spike protein elicit neutralizing antibodies in COVID-19 patients.
PMID: 32895485 [PubMed - as supplied by publisher] (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - September 6, 2020 Category: Molecular Biology Authors: Li Y, Lai DY, Zhang HN, Jiang HW, Tian X, Ma ML, Qi H, Meng QF, Guo SJ, Wu Y, Wang W, Yang X, Shi DW, Dai JB, Ying T, Zhou J, Tao SC Tags: Cell Mol Immunol Source Type: research

Kruppel-like factor 10 protects against acute viral myocarditis by negatively regulating cardiac MCP-1 expression.
In this study, we report that cardiac KLF10 confers enhanced protection against viral myocarditis. We found that KLF10 expression was downregulated upon CVB3 infection. KLF10 deficiency enhanced cardiac viral replication and aggravated VMC progress. Bone marrow chimera experiments indicated that KLF10 expression in nonhematopoietic cells was involved in the pathogenesis of VMC. We further identified MCP-1 as a novel target of KLF10 in cardiomyocytes, and KLF10 cooperated with histone deacetylase 1 (HDAC1) to negatively regulate MCP-1 expression by binding its promoter, leading to activation of MCP-1 transcription and recru...
Source: Cellular and Molecular Immunology - September 6, 2020 Category: Molecular Biology Authors: Yang J, Zhang H, Wang X, Guo J, Wei L, Song Y, Luo Y, Zhao Y, Subramaniam M, Spelsberg TC, Wang L, Xu W, Li M Tags: Cell Mol Immunol Source Type: research

Correction to: Glutamate triggers the expression of functional ionotropic and metabotropic glutamate receptors in mast cells.
Abstract An amendment to this paper has been published and can be accessed via a link at the top of the paper. PMID: 32884140 [PubMed - as supplied by publisher] (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - September 2, 2020 Category: Molecular Biology Authors: Alim MA, Grujic M, Ackermann PW, Kristiansson P, Blomgran P, Eliasson P, Peterson M, Pejler G Tags: Cell Mol Immunol Source Type: research

Cell cycle-related kinase reprograms the liver immune microenvironment to promote cancer metastasis.
Abstract The liver is an immunologically tolerant organ and a common metastatic site of multiple cancer types. Although a role for cancer cell invasion programs has been well characterized, whether and how liver-intrinsic factors drive metastatic spread is incompletely understood. Here, we show that aberrantly activated hepatocyte-intrinsic cell cycle-related kinase (CCRK) signaling in chronic liver diseases is critical for cancer metastasis by reprogramming an immunosuppressive microenvironment. Using an inducible liver-specific transgenic model, we found that CCRK overexpression dramatically increased both B16F1...
Source: Cellular and Molecular Immunology - September 1, 2020 Category: Molecular Biology Authors: Zeng X, Zhou J, Xiong Z, Sun H, Yang W, Mok MTS, Wang J, Li J, Liu M, Tang W, Feng Y, Wang HK, Tsang SW, Chow KL, Yeung PC, Wong J, Lai PB, Chan AW, To KF, Chan SL, Xia Q, Xue J, Chen X, Yu J, Peng S, Sung JJ, Kuang M, Cheng AS Tags: Cell Mol Immunol Source Type: research

OTUD5 promotes innate antiviral and antitumor immunity through deubiquitinating and stabilizing STING.
Abstract Stimulator of interferon genes (STING) is an adaptor protein that is critical for effective innate antiviral and antitumor immunity. The activity of STING is heavily regulated by protein ubiquitination, which is fine-tuned by both E3 ubiquitin ligases and deubiquitinases. Here, we report that the deubiquitinase OTUD5 interacts with STING, cleaves its K48-linked polyubiquitin chains, and promotes its stability. Consistently, knockout of OTUD5 resulted in faster turnover of STING and subsequently impaired type I IFN signaling following cytosolic DNA stimulation. More importantly, Lyz2-Cre Otud5fl/Y mice and...
Source: Cellular and Molecular Immunology - September 1, 2020 Category: Molecular Biology Authors: Guo Y, Jiang F, Kong L, Wu H, Zhang H, Chen X, Zhao J, Cai B, Li Y, Ma C, Yi F, Zhang L, Liu B, Zheng Y, Zhang L, Gao C Tags: Cell Mol Immunol Source Type: research

The dynamic profile and potential function of B-cell subsets during pregnancy.
PMID: 32879470 [PubMed - as supplied by publisher] (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - September 1, 2020 Category: Molecular Biology Authors: Wang L, Jiang P, Zhao S, Liu H, Liu L, Mor G, Liu C, Liao A Tags: Cell Mol Immunol Source Type: research

Expansion of atypical memory B cells is a prominent feature of COVID-19.
PMID: 32879471 [PubMed - as supplied by publisher] (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - September 1, 2020 Category: Molecular Biology Authors: Oliviero B, Varchetta S, Mele D, Mantovani S, Cerino A, Perotti CG, Ludovisi S, Mondelli MU Tags: Cell Mol Immunol Source Type: research

Human immunology and immunotherapy: main achievements and challenges.
lez-Fernández Á Abstract The immune system is a fascinating world of cells, soluble factors, interacting cells, and tissues, all of which are interconnected. The highly complex nature of the immune system makes it difficult to view it as a whole, but researchers are now trying to put all the pieces of the puzzle together to obtain a more complete picture. The development of new specialized equipment and immunological techniques, genetic approaches, animal models, and a long list of monoclonal antibodies, among many other factors, are improving our knowledge of this sophisticated system. The different...
Source: Cellular and Molecular Immunology - September 1, 2020 Category: Molecular Biology Authors: Varadé J, Magadán S, González-Fernández Á Tags: Cell Mol Immunol Source Type: research

Correction to: Cancer immunotherapy with γδ T cells: many paths ahead of us.
Correction to: Cancer immunotherapy with γδ T cells: many paths ahead of us. Cell Mol Immunol. 2020 Sep 01;: Authors: Kabelitz D, Serrano R, Kouakanou L, Peters C, Kalyan S Abstract An amendment to this paper has been published and can be accessed via a link at the top of the paper. PMID: 32873864 [PubMed - as supplied by publisher] (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - August 31, 2020 Category: Molecular Biology Authors: Kabelitz D, Serrano R, Kouakanou L, Peters C, Kalyan S Tags: Cell Mol Immunol Source Type: research

New insights into the cell-  and tissue-specificity of glucocorticoid actions.
New insights into the cell- and tissue-specificity of glucocorticoid actions. Cell Mol Immunol. 2020 Aug 31;: Authors: Quatrini L, Ugolini S Abstract Glucocorticoids (GCs) are endogenous hormones that are crucial for the homeostasis of the organism and adaptation to the external environment. Because of their anti-inflammatory effects, synthetic GCs are also extensively used in clinical practice. However, almost all cells in the body are sensitive to GC regulation. As a result, these mediators have pleiotropic effects, which may be undesirable or detrimental to human health. Here, we summarize the...
Source: Cellular and Molecular Immunology - August 30, 2020 Category: Molecular Biology Authors: Quatrini L, Ugolini S Tags: Cell Mol Immunol Source Type: research

Shared and distinct roles of T peripheral helper and T follicular helper cells in human diseases.
Abstract The interactions of CD4+ T cells and B cells are fundamental for the generation of protective antibody responses, as well as for the development of harmful autoimmune diseases. Recent studies of human tissues and blood samples have established a new subset of CD4+ B helper T cells named peripheral helper T (Tph) cells. Unlike T follicular helper (Tfh) cells, which interact with B cells within lymphoid organs, Tph cells provide help to B cells within inflamed tissues. Tph cells share many B helper-associated functions with Tfh cells and induce B cell differentiation toward antibody-producing cells. The dif...
Source: Cellular and Molecular Immunology - August 30, 2020 Category: Molecular Biology Authors: Yoshitomi H, Ueno H Tags: Cell Mol Immunol Source Type: research

Chronic activation of 4-1BB signaling induces granuloma development in tumor-draining lymph nodes that is detrimental to subsequent CD8+ T cell responses.
Abstract The antitumor capabilities of agonistic anti-4-1BB mAbs have made them an attractive target for tumor immunotherapy. However, the adverse side effects associated with agonist antibodies have hindered their clinical development. Here, we aimed to study the immune-related adverse events of repeated doses and long-term use of agonistic anti-4-1BB mAbs. We show that chronic activation of 4-1BB signals induced the accumulation of IFN-γ-producing PD-1+CD8+ T cells in the secondary lymphoid organs of tumor-bearing mice by increasing the number of dividing CD8+ T cells, which was beneficial for suppressing ...
Source: Cellular and Molecular Immunology - August 30, 2020 Category: Molecular Biology Authors: Kim SH, Singh R, Han C, Cho E, Kim YI, Lee DG, Kim YH, Kim SS, Shin DH, You HJ, Lee HW, Kwon BS, Choi BK Tags: Cell Mol Immunol Source Type: research

Exploring the stage-specific roles of Tcf-1 in T cell development and malignancy at single-cell resolution.
In this study, Tcf7fl/fl mice were crossed with Vav-cre, Lck-cre, or Cd4-cre mice to delete Tcf-1 conditionally at the beginning of the HSC, DN2-DN3, or DP stage, respectively. The defective T cell development phenotypes became gradually less severe as the deletion stage became more advanced in distinct mouse models. Interestingly, consistent with Tcf7-/- mice, Tcf7fl/flVav-cre mice developed aggressive T cell lymphoma within 45 weeks, but no tumors were generated in Tcf7fl/flLck-cre or Tcf7fl/flCd4-cre mice. Single-cell RNA-seq (ScRNA-seq) indicated that ablation of Tcf-1 at distinct phases can subdivide DN1 cells into th...
Source: Cellular and Molecular Immunology - August 30, 2020 Category: Molecular Biology Authors: Wang F, Qi Z, Yao Y, Yu G, Feng T, Zhao T, Xue HH, Zhao Y, Jiang P, Bao L, Yu S Tags: Cell Mol Immunol Source Type: research

DNA methylation profile of a hepatosplenic gamma/delta T-cell lymphoma patient associated with response to interferon- α therapy.
DNA methylation profile of a hepatosplenic gamma/delta T-cell lymphoma patient associated with response to interferon-α therapy. Cell Mol Immunol. 2020 Aug 20;: Authors: Bhat J, Bergmann AK, Waschina S, Nerl C, Kaleta C, Siebert R, Ammerpohl O, Kabelitz D PMID: 32820235 [PubMed - as supplied by publisher] (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - August 19, 2020 Category: Molecular Biology Authors: Bhat J, Bergmann AK, Waschina S, Nerl C, Kaleta C, Siebert R, Ammerpohl O, Kabelitz D Tags: Cell Mol Immunol Source Type: research

"Autoinflammatory psoriasis"-genetics and biology of pustular psoriasis.
"Autoinflammatory psoriasis"-genetics and biology of pustular psoriasis. Cell Mol Immunol. 2020 Aug 19;: Authors: Uppala R, Tsoi LC, Harms PW, Wang B, Billi AC, Maverakis E, Michelle Kahlenberg J, Ward NL, Gudjonsson JE Abstract Psoriasis is a chronic inflammatory skin condition that has a fairly wide range of clinical presentations. Plaque psoriasis, which is the most common manifestation of psoriasis, is located on one end of the spectrum, dominated by adaptive immune responses, whereas the rarer pustular psoriasis lies on the opposite end, dominated by innate and autoinflammatory immune r...
Source: Cellular and Molecular Immunology - August 18, 2020 Category: Molecular Biology Authors: Uppala R, Tsoi LC, Harms PW, Wang B, Billi AC, Maverakis E, Michelle Kahlenberg J, Ward NL, Gudjonsson JE Tags: Cell Mol Immunol Source Type: research

Beyond monogenetic rare variants: tackling the low rate of genetic diagnoses in predominantly antibody deficiency.
Abstract Predominantly antibody deficiency (PAD) is the most prevalent form of primary immunodeficiency, and is characterized by broad clinical, immunological and genetic heterogeneity. Utilizing the current gold standard of whole exome sequencing for diagnosis, pathogenic gene variants are only identified in less than 20% of patients. While elucidation of the causal genes underlying PAD has provided many insights into the cellular and molecular mechanisms underpinning disease pathogenesis, many other genes may remain as yet undefined to enable definitive diagnosis, prognostic monitoring and targeted therapy ...
Source: Cellular and Molecular Immunology - August 16, 2020 Category: Molecular Biology Authors: Edwards ESJ, Bosco JJ, Ojaimi S, O'Hehir RE, van Zelm MC Tags: Cell Mol Immunol Source Type: research

Primed macrophages gain long-term specific memory to reject allogeneic tissues in mice.
PMID: 32801366 [PubMed - as supplied by publisher] (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - August 16, 2020 Category: Molecular Biology Authors: Chu Z, Feng C, Sun C, Xu Y, Zhao Y Tags: Cell Mol Immunol Source Type: research

Manganese enhances the antitumor function of CD8+ T cells by inducing type I interferon production.
PMID: 32801367 [PubMed - as supplied by publisher] (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - August 16, 2020 Category: Molecular Biology Authors: Song Y, Liu Y, Teo HY, Hanafi ZB, Mei Y, Zhu Y, Chua YL, Lv M, Jiang Z, Liu H Tags: Cell Mol Immunol Source Type: research

NMP4: a nuclear driver of innate inflammatory responses during influenza A virus infection.
PMID: 32747686 [PubMed - as supplied by publisher] (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - August 2, 2020 Category: Molecular Biology Authors: Boehme JD, Frentzel S, Bruder D Tags: Cell Mol Immunol Source Type: research

IL-33: a key player in the development of iron-recycling red pulp macrophages.
PMID: 32737432 [PubMed - as supplied by publisher] (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - July 30, 2020 Category: Molecular Biology Authors: Xu D, Huang SK Tags: Cell Mol Immunol Source Type: research

A recently described type 2 conventional dendritic cell (cDC2) subset mediates inflammation.
PMID: 32732988 [PubMed - as supplied by publisher] (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - July 29, 2020 Category: Molecular Biology Authors: Shin JY, Wang CY, Lin CC, Chu CL Tags: Cell Mol Immunol Source Type: research

SARS-CoV-2 Orf9b suppresses type I interferon responses by targeting TOM70.
PMID: 32728199 [PubMed - as supplied by publisher] (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - July 28, 2020 Category: Molecular Biology Authors: Jiang HW, Zhang HN, Meng QF, Xie J, Li Y, Chen H, Zheng YX, Wang XN, Qi H, Zhang J, Wang PH, Han ZG, Tao SC Tags: Cell Mol Immunol Source Type: research

The soluble glycoprotein NMB (GPNMB) produced by macrophages induces cancer stemness and metastasis via CD44 and IL-33.
We reported that the protein GPNMB (glycoprotein nonmetastatic B) was profoundly upregulated in macrophages interacting with tumor cells. Here, using mouse tumor models, we show that macrophage-derived soluble GPNMB increases tumor growth and metastasis in Gpnmb-mutant mice (DBA/2J). GPNMB triggers in the cancer cells the formation of self-renewing spheroids, which are characterized by the expression of cancer stem cell markers, prolonged cell survival and increased tumor-forming ability. Through the CD44 receptor, GPNMB mechanistically activates tumor cells to express the cytokine IL-33 and its receptor IL-1R1L. We a...
Source: Cellular and Molecular Immunology - July 28, 2020 Category: Molecular Biology Authors: Liguori M, Digifico E, Vacchini A, Avigni R, Colombo FS, Borroni EM, Farina FM, Milanesi S, Castagna A, Mannarino L, Craparotta I, Marchini S, Erba E, Panini N, Tamborini M, Rimoldi V, Allavena P, Belgiovine C Tags: Cell Mol Immunol Source Type: research