Functional phenotypes of CCR5 on CD4+ T cells of relevance to its genetic and epigenetic associations with HIV infection.
PMID: 31900454 [PubMed - as supplied by publisher] (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - January 3, 2020 Category: Molecular Biology Authors: Skundric DS, Tse HY, Montgomery PC Tags: Cell Mol Immunol Source Type: research

Galactose supramolecular docking orchestrates macrophage phenotype.
PMID: 31900455 [PubMed - as supplied by publisher] (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - January 3, 2020 Category: Molecular Biology Authors: Zhang N, Zheng X, Couvee G, Wolterboer F, Zhou Y, deDonk OV, Yang H, Simone G Tags: Cell Mol Immunol Source Type: research

A serine protease inhibitor induces type 1 regulatory T cells through IFN- γ/STAT1 signaling.
A serine protease inhibitor induces type 1 regulatory T cells through IFN-γ/STAT1 signaling. Cell Mol Immunol. 2020 Jan 03;: Authors: Safavi F, Thome R, Li Z, Wang L, Rasouli J, Ciric B, Zhang GX, Rostami A PMID: 31900456 [PubMed - as supplied by publisher] (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - January 3, 2020 Category: Molecular Biology Authors: Safavi F, Thome R, Li Z, Wang L, Rasouli J, Ciric B, Zhang GX, Rostami A Tags: Cell Mol Immunol Source Type: research

CD147 deficiency in T cells prevents thymic involution by inhibiting the EMT process in TECs in the presence of TGF β.
In this study, we illuminate the mechanism underlying the triggering of the EMT process in TECs and show that inhibiting TGFβ and/or CD147 may serve as a strategy to hinder age-related thymic involution. PMID: 31900457 [PubMed - as supplied by publisher] (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - January 3, 2020 Category: Molecular Biology Authors: Chen R, Wang K, Feng Z, Zhang MY, Wu J, Geng JJ, Chen ZN Tags: Cell Mol Immunol Source Type: research

Plasmacytoid dendritic cells promote acute kidney injury by producing interferon- α.
Plasmacytoid dendritic cells promote acute kidney injury by producing interferon-α. Cell Mol Immunol. 2020 Jan 03;: Authors: Deng B, Lin Y, Chen Y, Ma S, Cai Q, Wang W, Li B, Liu T, Zhou P, He R, Ding F Abstract Acute kidney injury (AKI) is a common clinical complication associated with high mortality in patients. Immune cells and cytokines have recently been described to play essential roles in AKI pathogenesis. Plasmacytoid dendritic cells (pDCs) are a unique DC subset that specializes in type I interferon (IFN) production. Here, we showed that pDCs rapidly infiltrated the kidney in response t...
Source: Cellular and Molecular Immunology - January 3, 2020 Category: Molecular Biology Authors: Deng B, Lin Y, Chen Y, Ma S, Cai Q, Wang W, Li B, Liu T, Zhou P, He R, Ding F Tags: Cell Mol Immunol Source Type: research

Efficiency and side effects of anti-CD38 CAR T cells in an adult patient with relapsed B-ALL after failure of bi-specific CD19/CD22 CAR T cell treatment.
PMID: 31900459 [PubMed - as supplied by publisher] (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - January 3, 2020 Category: Molecular Biology Authors: Guo Y, Feng K, Tong C, Jia H, Liu Y, Wang Y, Ti D, Yang Q, Wu Z, Han W Tags: Cell Mol Immunol Source Type: research

Inflammation-induced inhibition of chaperone-mediated autophagy maintains the immunosuppressive function of murine mesenchymal stromal cells.
Abstract Macroautophagy has been implicated in modulating the therapeutic function of mesenchymal stromal cells (MSCs). However, the biological function of chaperone-mediated autophagy (CMA) in MSCs remains elusive. Here, we found that CMA was inhibited in MSCs in response to the proinflammatory cytokines interferon-γ (IFN-γ) and tumor necrosis factor-α (TNF-α). In addition, suppression of CMA by knocking down the CMA-related lysosomal receptor lysosomal-associated membrane protein 2 (LAMP-2A) in MSCs significantly enhanced the immunosuppressive effect of MSCs on T cell proliferation, and a...
Source: Cellular and Molecular Immunology - January 3, 2020 Category: Molecular Biology Authors: Zhang J, Huang J, Gu Y, Xue M, Qian F, Wang B, Yang W, Yu H, Wang Q, Guo X, Ding X, Wang J, Jin M, Zhang Y Tags: Cell Mol Immunol Source Type: research

Spaceflight and simulated microgravity suppresses macrophage development via altered RAS/ERK/NF κB and metabolic pathways.
Spaceflight and simulated microgravity suppresses macrophage development via altered RAS/ERK/NFκB and metabolic pathways. Cell Mol Immunol. 2020 Jan 03;: Authors: Shi L, Tian H, Wang P, Li L, Zhang Z, Zhang J, Zhao Y Abstract Spaceflight-associated immune system weakening ultimately limits the ability of humans to expand their presence beyond the earth's orbit. A mechanistic study of microgravity-regulated immune cell function is necessary to overcome this challenge. Here, we demonstrate that both spaceflight (real) and simulated microgravity significantly reduce macrophage differentiation, decr...
Source: Cellular and Molecular Immunology - January 3, 2020 Category: Molecular Biology Authors: Shi L, Tian H, Wang P, Li L, Zhang Z, Zhang J, Zhao Y Tags: Cell Mol Immunol Source Type: research

Correction to: Measles virus hemagglutinin triggers intracellular signaling in CD150-expressing dendritic cells and inhibits immune response.
Abstract An amendment to this paper has been published and can be accessed via a link at the top of the paper. PMID: 31863080 [PubMed - as supplied by publisher] (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - December 20, 2019 Category: Molecular Biology Authors: Romanets-Korbut O, Kovalevska LM, Seya T, Sidorenko SP, Horvat B Tags: Cell Mol Immunol Source Type: research

Blocking PD-L1 for anti-liver cancer immunity: USP22 represents a critical cotarget.
PMID: 31857703 [PubMed - as supplied by publisher] (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - December 19, 2019 Category: Molecular Biology Authors: Huang X, Zhang X, Bai X, Liang T Tags: Cell Mol Immunol Source Type: research

For antigen-specific effector or Foxp3+ regulatory T cell fate, cyclin-dependent kinases hold the trump card.
PMID: 31857704 [PubMed - as supplied by publisher] (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - December 19, 2019 Category: Molecular Biology Authors: Bonam SR, Bayry J Tags: Cell Mol Immunol Source Type: research

Maternal milk ILCs and adaptive immune cells populate neonatal organs.
ban B PMID: 31857705 [PubMed - as supplied by publisher] (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - December 19, 2019 Category: Molecular Biology Authors: Yu JC, Khodadadi H, Lopes Salles ÉDS, Chibane F, Bhatia J, Baban B Tags: Cell Mol Immunol Source Type: research

Exhaustion and senescence: two crucial dysfunctional states of T cells in the tumor microenvironment.
Abstract The failure of a massive influx of tumor-infiltrating T lymphocytes to eradicate tumor cells in the tumor microenvironment is mainly due to the dysfunction of T cells hyporesponsive to tumors. T-cell exhaustion and senescence induced by malignant tumors are two important dysfunctional states that coexist in cancer patients, hindering effective antitumor immunity and immunotherapy and sustaining the suppressive tumor microenvironment. Although exhausted and senescent T cells share a similar dysfunctional role in antitumor immunity, they are distinctly different in terms of generation, development, and meta...
Source: Cellular and Molecular Immunology - December 18, 2019 Category: Molecular Biology Authors: Zhao Y, Shao Q, Peng G Tags: Cell Mol Immunol Source Type: research

Plasmacytoid dendritic cell deficiency in neonates enhances allergic airway inflammation via reduced production of IFN- α.
We report here that this pDC deficiency renders neonatal mice more susceptible to severe allergic airway inflammation than adult mice in an OVA-induced experimental asthma model. Adoptive transfer of pDCs or administration of IFN-α to neonatal mice prevented the development of allergic inflammation in wild type but not in IFNAR1-/- mice. Similarly, adult mice developed more severe allergic inflammation when pDCs were depleted. The protective effects of pDCs were mediated by the pDC-/IFN-α-mediated negative regulation of the secretion of epithelial cell-derived CCL20, GM-CSF, and IL-33, which in turn impaired th...
Source: Cellular and Molecular Immunology - December 18, 2019 Category: Molecular Biology Authors: Wu M, Gao L, He M, Liu H, Jiang H, Shi K, Shang R, Liu B, Gao S, Chen H, Gong F, Gelfand EW, Huang Y, Han J Tags: Cell Mol Immunol Source Type: research

Targeting innate sensing in the tumor microenvironment to improve immunotherapy.
Abstract The innate immune sensing pathways play critical roles in the defense against pathogen infection, but their roles in cancer immunosurveillance and cancer therapies are less defined. We propose that defective innate immune sensing inside the tumor microenvironment might limit T-cell responses to immunotherapy. A recent mechanistic understanding of conventional therapies revealed that both innate immune sensing and T-cell responses are essential for optimal antitumor efficacy. T-cell-based immunotherapy, particularly immune checkpoint blockade, has achieved great success in reactivating antitumor immune res...
Source: Cellular and Molecular Immunology - December 16, 2019 Category: Molecular Biology Authors: Liu Z, Han C, Fu YX Tags: Cell Mol Immunol Source Type: research

Correction to: Low-dose decitabine enhances the effect of PD-1 blockade in colorectal cancer with microsatellite stability by re-modulating the tumor microenvironment.
Abstract An amendment to this paper has been published and can be accessed via a link at the top of the paper. PMID: 31827263 [PubMed - as supplied by publisher] (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - December 11, 2019 Category: Molecular Biology Authors: Yu G, Wu Y, Wang W, Xu J, Lv X, Cao X, Wan T Tags: Cell Mol Immunol Source Type: research

Molecular anatomy and pathogenic actions of Helicobacter pylori CagA that underpin gastric carcinogenesis.
Abstract Chronic infection with Helicobacter pylori cagA-positive strains is the strongest risk factor for gastric cancer. The cagA gene product, CagA, is delivered into gastric epithelial cells via the bacterial type IV secretion system. Delivered CagA then undergoes tyrosine phosphorylation at the Glu-Pro-Ile-Tyr-Ala (EPIYA) motifs in its C-terminal region and acts as an oncogenic scaffold protein that physically interacts with multiple host signaling proteins in both tyrosine phosphorylation-dependent and -independent manners. Analysis of CagA using in vitro cultured gastric epithelial cells has indicated that ...
Source: Cellular and Molecular Immunology - December 5, 2019 Category: Molecular Biology Authors: Takahashi-Kanemitsu A, Knight CT, Hatakeyama M Tags: Cell Mol Immunol Source Type: research

Serum-circulating His-tRNA synthetase inhibits organ-targeted immune responses.
Abstract His-tRNA synthetase (HARS) is targeted by autoantibodies in chronic and acute inflammatory anti-Jo-1-positive antisynthetase syndrome. The extensive activation and migration of immune cells into lung and muscle are associated with interstitial lung disease, myositis, and morbidity. It is unknown whether the sequestration of HARS is an epiphenomenon or plays a causal role in the disease. Here, we show that HARS circulates in healthy individuals, but it is largely undetectable in the serum of anti-Jo-1-positive antisynthetase syndrome patients. In cultured primary human skeletal muscle myoblasts (HSkMC), HA...
Source: Cellular and Molecular Immunology - December 4, 2019 Category: Molecular Biology Authors: Adams RA, Fernandes-Cerqueira C, Notarnicola A, Mertsching E, Xu Z, Lo WS, Ogilvie K, Chiang KP, Ampudia J, Rosengren S, Cubitt A, King DJ, Mendlein JD, Yang XL, Nangle LA, Lundberg IE, Jakobsson PJ, Schimmel P Tags: Cell Mol Immunol Source Type: research

Anti-IgE IgG autoantibodies isolated from therapeutic normal IgG intravenous immunoglobulin induce basophil activation.
PMID: 31797906 [PubMed - as supplied by publisher] (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - December 4, 2019 Category: Molecular Biology Authors: Galeotti C, Karnam A, Dimitrov JD, Chevailler A, Kaveri SV, Bayry J Tags: Cell Mol Immunol Source Type: research

Correction to: TGF-beta1 gene-modified, immature dendritic cells delay the development of inflammatory bowel disease by inducing CD4(+)Foxp3(+) regulatory T cells.
Abstract An amendment to this paper has been published and can be accessed via a link at the top of the paper. PMID: 31784682 [PubMed - as supplied by publisher] (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - November 29, 2019 Category: Molecular Biology Authors: Cai Z, Zhang W, Li M, Yue Y, Yang F, Yu L, Cao X, Wang J Tags: Cell Mol Immunol Source Type: research

Correction to: The methyltransferase PRMT6 attenuates antiviral innate immunity by blocking TBK1-IRF3 signaling.
Abstract An amendment to this paper has been published and can be accessed via a link at the top of the paper. PMID: 31776454 [PubMed - as supplied by publisher] (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - November 27, 2019 Category: Molecular Biology Authors: Zhang H, Han C, Li T, Li N, Cao X Tags: Cell Mol Immunol Source Type: research

Correction to: MicroRNA in vivo precipitation identifies miR-151-3p as a computational unpredictable miRNA to target Stat3 and inhibits innate IL-6 production.
Abstract An amendment to this paper has been published and can be accessed via a link at the top of the paper. PMID: 31776455 [PubMed - as supplied by publisher] (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - November 27, 2019 Category: Molecular Biology Authors: Liu X, Su X, Xu S, Wang H, Han D, Li J, Huang M, Cao X Tags: Cell Mol Immunol Source Type: research

Correction: HSP70L1-mediated intracellular priming of dendritic cell vaccination induces more potent CTL response against cancer.
Abstract An amendment to this paper has been published and can be accessed via a link at the top of the paper. PMID: 31772283 [PubMed - as supplied by publisher] (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - November 26, 2019 Category: Molecular Biology Authors: Liu S, Yi L, Ma L, Jiang J, Song L, Liu J, Cao X Tags: Cell Mol Immunol Source Type: research

MicroRNA-33/33* inhibit the activation of MAVS through AMPK in antiviral innate immunity.
Abstract Innate immunity plays a prominent role in the host defense against pathogens and must be precisely regulated. As vital orchestrators in cholesterol homeostasis, microRNA-33/33* have been widely investigated in cellular metabolism. However, their role in antiviral innate immunity is largely unknown. Here, we report that VSV stimulation decreased the expression of miR-33/33* through an IFNAR-dependent manner in macrophages. Overexpression of miR-33/33* resulted in impaired RIG-I signaling, enhancing viral load and lethality whereas attenuating type I interferon production both in vitro and in vivo. In ...
Source: Cellular and Molecular Immunology - November 25, 2019 Category: Molecular Biology Authors: Liu D, Tan Q, Zhu J, Zhang Y, Xue Y, Song Y, Liu Y, Wang Q, Lai L Tags: Cell Mol Immunol Source Type: research

HBsAg-specific CD8+ T cells as an indispensable trigger to induce murine hepatocellular carcinoma.
Abstract Hepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC) is mediated by an inappropriate attack by HBV-specific T cells in patients. However, this immunopathogenic process has not been clarified because of the lack of a suitable animal model. Here, we used immunocompetent Fah-/- mice as the recipients in the adoptive transfer of HBsAg+ hepatocytes from HBs-Tg mice to replace the recipient hepatocytes (HBs-HepR). HBs-HepR mice exhibited persistent HBsAg expression with chronic hepatitis and eventually developed HCC with a prevalence of 100%. HBsAg-specific CD8+ T cells were generated and specifica...
Source: Cellular and Molecular Immunology - November 25, 2019 Category: Molecular Biology Authors: Hao X, Chen Y, Bai L, Wei H, Sun R, Tian Z Tags: Cell Mol Immunol Source Type: research

An optimized method to differentiate mouse follicular helper T cells in vitro.
PMID: 31754234 [PubMed - as supplied by publisher] (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - November 21, 2019 Category: Molecular Biology Authors: Gao X, Wang H, Chen Z, Zhou P, Yu D Tags: Cell Mol Immunol Source Type: research

Cancer-derived sialylated IgG promotes tumor immune escape by binding to Siglecs on effector T cells.
Abstract To date, IgG in the tumor microenvironment (TME) has been considered a product of B cells and serves as an antitumor antibody. However, in this study, using a monoclonal antibody against cancer-derived IgG (Cancer-IgG), we found that cancer cells could secrete IgG into the TME. Furthermore, Cancer-IgG, which carries an abnormal sialic acid modification in the CH1 domain, directly inhibited effector T-cell proliferation and significantly promoted tumor growth by reducing CD4+ and CD8+ T-cell infiltration into tumor tissues. Mechanistic studies showed that the immunosuppressive effect of sialylated Cancer-I...
Source: Cellular and Molecular Immunology - November 21, 2019 Category: Molecular Biology Authors: Wang Z, Geng Z, Shao W, Liu E, Zhang J, Tang J, Wang P, Sun X, Xiao L, Xu W, Zhang Y, Cui H, Zhang L, Yang X, Chang X, Qiu X Tags: Cell Mol Immunol Source Type: research

The intragraft vascularized bone marrow component plays a critical role in tolerance induction after reconstructive transplantation.
In this study, vascularized composite tissue allograft transplantation outcomes between recipients receiving either conventional bone marrow transplantation (CBMT) or vascularized bone marrow (VBM) transplantation from Balb/c (H2d) to C57BL/6 (H2b) mice were compared. Either high- or low-dose CBMT (1.5 × 108 or 3 × 107 bone marrow cells, respectively) was applied. In addition, recipients were treated with costimulation blockade (1 mg anti-CD154 and 0.5 mg CTLA4Ig on postoperative days 0 and 2, respectively) and short-term rapamycin (3 mg/kg/day for the first post...
Source: Cellular and Molecular Immunology - November 21, 2019 Category: Molecular Biology Authors: Lin CH, Anggelia MR, Cheng HY, Wang AYL, Chuang WY, Lin CH, Lee WPA, Wei FC, Brandacher G Tags: Cell Mol Immunol Source Type: research

Electrostatic complementarity of B-cell receptor CDR3s and TP53-mutant amino acids in breast cancer is associated with increased disease-free survival rates.
PMID: 31729463 [PubMed - as supplied by publisher] (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - November 15, 2019 Category: Molecular Biology Authors: Arturo JF, Chobrutskiy BI, Yeagley M, Patel DN, Falasiri S, Patel JS, Blanck G Tags: Cell Mol Immunol Source Type: research

CUL4B negatively regulates Toll-like receptor-triggered proinflammatory responses by repressing Pten transcription.
Abstract Toll-like receptors (TLRs) play critical roles in innate immunity and inflammation. The molecular mechanisms by which TLR signaling is fine-tuned remain to be completely elucidated. Cullin 4B (CUL4B), which assembles the CUL4B-RING E3 ligase complex (CRL4B), has been shown to regulate diverse developmental and physiological processes by catalyzing monoubiquitination for histone modification or polyubiquitination for proteasomal degradation. Here, we identified the role of CUL4B as an intrinsic negative regulator of the TLR-triggered inflammatory response. Deletion of CUL4B in macrophages increased the pro...
Source: Cellular and Molecular Immunology - November 15, 2019 Category: Molecular Biology Authors: Song Y, Li P, Qin L, Xu Z, Jiang B, Ma C, Shao C, Gong Y Tags: Cell Mol Immunol Source Type: research

Dendritic cells license regulatory B cells to produce IL-10 and mediate suppression of antigen-specific CD8 T cells.
Abstract Regulatory B cells (Bregs) suppress and reduce autoimmune pathology. However, given the variety of Breg subsets, the role of Bregs in the pathogenesis of type 1 diabetes is still unclear. Here, we dissect this fundamental mechanism. We show that natural protection from type 1 diabetes in nonobese diabetic (NOD) mice is associated with increased numbers of IL-10-producing B cells, while development of type 1 diabetes in NOD mice occurs in animals with compromised IL-10 production by B cells. However, B cells from diabetic mice regain IL-10 function if activated by the innate immune receptor TLR4 and can su...
Source: Cellular and Molecular Immunology - November 14, 2019 Category: Molecular Biology Authors: Boldison J, Da Rosa LC, Davies J, Wen L, Wong FS Tags: Cell Mol Immunol Source Type: research

LILRB4 ITIMs mediate the T cell suppression and infiltration of acute myeloid leukemia cells.
Abstract We recently demonstrated that leukocyte Ig-like receptor 4 (LILRB4) expressed by monocytic acute myeloid leukemia (AML) cells mediates T-cell inhibition and leukemia cell infiltration via its intracellular domain. The cytoplasmic domain of LILRB4 contains three immunoreceptor tyrosine-based inhibitory motifs (ITIMs); the tyrosines at positions 360, 412, and 442 are phosphorylation sites. Here, we analyzed how the ITIMs of LILRB4 in AML cells mediate its function. Our in vitro and in vivo data show that Y412 and Y442, but not Y360, of LILRB4 are required for T-cell inhibition, and all three ITIMs are neede...
Source: Cellular and Molecular Immunology - November 7, 2019 Category: Molecular Biology Authors: Li Z, Deng M, Huang F, Jin C, Sun S, Chen H, Liu X, He L, Sadek AH, Zhang CC Tags: Cell Mol Immunol Source Type: research

Strong association of regulatory single nucleotide polymorphisms (SNPs) of the IFITM3 gene with influenza H1N1 2009 pandemic virus infection.
PMID: 31685927 [PubMed - as supplied by publisher] (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - November 4, 2019 Category: Molecular Biology Authors: Kim YC, Jeong MJ, Jeong BH Tags: Cell Mol Immunol Source Type: research

Jagged1-mediated myeloid Notch1 signaling activates HSF1/Snail and controls NLRP3 inflammasome activation in liver inflammatory injury.
Abstract Notch signaling plays important roles in the regulation of immune cell functioning during the inflammatory response. Activation of the innate immune signaling receptor NLRP3 promotes inflammation in injured tissue. However, it remains unknown whether Jagged1 (JAG1)-mediated myeloid Notch1 signaling regulates NLRP3 function in acute liver injury. Here, we report that myeloid Notch1 signaling regulates the NLRP3-driven inflammatory response in ischemia/reperfusion (IR)-induced liver injury. In a mouse model of liver IR injury, Notch1-proficient (Notch1FL/FL) mice receiving recombinant JAG1 showed a reductio...
Source: Cellular and Molecular Immunology - October 31, 2019 Category: Molecular Biology Authors: Jin Y, Li C, Xu D, Zhu J, Wei S, Zhong A, Sheng M, Duarte S, Coito AJ, Busuttil RW, Xia Q, Kupiec-Weglinski JW, Ke B Tags: Cell Mol Immunol Source Type: research

Exosomal microRNA in autoimmunity.
PMID: 31664221 [PubMed - as supplied by publisher] (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - October 29, 2019 Category: Molecular Biology Authors: Duan W, Zhang W, Jia J, Lu Q, Eric Gershwin M Tags: Cell Mol Immunol Source Type: research

Glycomolecules in Echinococcus granulosus cyst fluid inhibit TLR4-mediated inflammatory responses via c-Raf.
PMID: 31664222 [PubMed - as supplied by publisher] (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - October 29, 2019 Category: Molecular Biology Authors: Hou J, Li L, Dong D, Wang L, Wang X, Yang K, Xu X, Chen C, Wu X, Chen X Tags: Cell Mol Immunol Source Type: research

Loss of Lkb1 impairs Treg function and stability to aggravate graft-versus-host disease after bone marrow transplantation.
In this study, we demonstrated that Tregs were more dramatically decreased in bone marrow compared with those in peripheral blood from aGVHD patients and that bone marrow Treg defects were negatively associated with hematopoietic reconstitution. Tregs from aGVHD patients exhibited multiple defects, including the instability of Foxp3 expression, especially in response to IL-12, impaired suppressor function, decreased migratory capacity, and increased apoptosis. Transcriptional profiling revealed the downregulation of Lkb1, a previously identified critical regulator of murine Treg identity and metabolism, and murine Lkb1-reg...
Source: Cellular and Molecular Immunology - October 29, 2019 Category: Molecular Biology Authors: Su X, Wang Q, Guo W, Pei X, Niu Q, Liu M, Liu Y, Chen S, Feng S, He Y, Yang D, Zhang R, Ma Q, Zhai W, Pang A, Wei J, Huang Y, Luo Y, Han M, Feng X, Jiang E Tags: Cell Mol Immunol Source Type: research

JAK inhibitors alter NK cell functions and may impair immunosurveillance against lymphomagenesis.
PMID: 31664224 [PubMed - as supplied by publisher] (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - October 29, 2019 Category: Molecular Biology Authors: Nocturne G, Pascaud J, Ly B, Tahmasebi F, Mariette X Tags: Cell Mol Immunol Source Type: research

Epigenetic regulation of macrophages: from homeostasis maintenance to host defense.
Abstract Macrophages are crucial members of the innate immune response and important regulators. The differentiation and activation of macrophages require the timely regulation of gene expression, which depends on the interaction of a variety of factors, including transcription factors and epigenetic modifications. Epigenetic changes also give macrophages the ability to switch rapidly between cellular programs, indicating the ability of epigenetic mechanisms to affect phenotype plasticity. In this review, we focus on key epigenetic events associated with macrophage fate, highlighting events related to the maintena...
Source: Cellular and Molecular Immunology - October 29, 2019 Category: Molecular Biology Authors: Chen S, Yang J, Wei Y, Wei X Tags: Cell Mol Immunol Source Type: research

Immunological memory: ILC1s come into view.
PMID: 31659244 [PubMed - as supplied by publisher] (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - October 28, 2019 Category: Molecular Biology Authors: Chen Y, Tian Z, Peng H Tags: Cell Mol Immunol Source Type: research

FOXP3 protects conventional human T cells from premature restimulation-induced cell death.
Abstract The adaptive immune response relies on specific apoptotic programs to maintain homeostasis. Conventional effector T cell (Tcon) expansion is constrained by both forkhead box P3 (FOXP3)+-regulatory T cells (Tregs) and restimulation-induced cell death (RICD), a propriocidal apoptosis pathway triggered by repeated stimulation through the T-cell receptor (TCR). Constitutive FOXP3 expression protects Tregs from RICD by suppressing SLAM-associated protein (SAP), a key adaptor protein that amplifies TCR signaling strength. The role of transient FOXP3 induction in activated human CD4 and CD8 Tcons remains unresol...
Source: Cellular and Molecular Immunology - October 28, 2019 Category: Molecular Biology Authors: Voss K, Lake C, Luthers CR, Lott NM, Dorjbal B, Arjunaraja S, Bauman BM, Soltis AR, Sukumar G, Dalgard CL, Snow AL Tags: Cell Mol Immunol Source Type: research

Impact of human sequences in variable domains of therapeutic antibodies on the location of CD4 T-cell epitopes.
;re B PMID: 31659246 [PubMed - as supplied by publisher] (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - October 28, 2019 Category: Molecular Biology Authors: Meunier S, Hamze M, Karle A, de Bourayne M, Gdoura A, Spindeldreher S, Maillère B Tags: Cell Mol Immunol Source Type: research

Macrophages reprogrammed by lung cancer microparticles promote tumor development via release of IL-1 β.
Macrophages reprogrammed by lung cancer microparticles promote tumor development via release of IL-1β. Cell Mol Immunol. 2019 Oct 24;: Authors: Chen J, Sun W, Zhang H, Ma J, Xu P, Yu Y, Fang H, Zhou L, Lv J, Xie J, Liu Y, Tang K, Huang B Abstract Despite their mutual antagonism, inflammation and immunosuppression coexist in tumor microenvironments due to tumor and immune cell interactions, but the underlying mechanism remains unclear. Previously, we showed that tumor cell-derived microparticles induce an M2 phenotype characterized by immunosuppression in tumor-infiltrating macrophages. Here, we f...
Source: Cellular and Molecular Immunology - October 24, 2019 Category: Molecular Biology Authors: Chen J, Sun W, Zhang H, Ma J, Xu P, Yu Y, Fang H, Zhou L, Lv J, Xie J, Liu Y, Tang K, Huang B Tags: Cell Mol Immunol Source Type: research

Implications of m6A modification in autoimmune disorders.
PMID: 31649306 [PubMed - as supplied by publisher] (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - October 24, 2019 Category: Molecular Biology Authors: Paramasivam A, Priyadharsini JV, Raghunandhakumar S Tags: Cell Mol Immunol Source Type: research

A dominant insulin-specific and islet-destructive T-cell response is sufficient to activate CD8 T cells directed against the fatty-acid receptor GPR40.
PMID: 31649307 [PubMed - as supplied by publisher] (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - October 24, 2019 Category: Molecular Biology Authors: Spyrantis A, Krieger J, Stifter K, Boehm BO, Schirmbeck R Tags: Cell Mol Immunol Source Type: research

The expanding functional diversity of plasma cells in immunity and inflammation.
PMID: 31649308 [PubMed - as supplied by publisher] (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - October 24, 2019 Category: Molecular Biology Authors: Ma K, Wang X, Shi X, Lin X, Xiao F, Ma X, Liu D, Lu L Tags: Cell Mol Immunol Source Type: research

Intrinsic T-cell regulator miR-142-3p/5p - a novel therapeutic target?
PMID: 31649309 [PubMed - as supplied by publisher] (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - October 24, 2019 Category: Molecular Biology Authors: Dolff S, Abdulahad WH, Wilde B Tags: Cell Mol Immunol Source Type: research

Anti-inflammatory mechanisms of the novel cytokine interleukin-38 in allergic asthma.
Abstract We elucidated the anti-inflammatory mechanisms of IL-38 in allergic asthma. Human bronchial epithelial cells and eosinophils were cocultured upon stimulation with the viral RLR ligand poly (I:C)/LyoVec or infection-related cytokine TNF-α to induce expression of cytokines/chemokines/adhesion molecules. House dust mite (HDM)-induced allergic asthma and humanized allergic asthma NOD/SCID murine models were established to assess anti-inflammatory mechanisms in vivo. IL-38 significantly inhibited induced proinflammatory IL-6, IL-1β, CCL5, and CXCL10 production, and antiviral interferon-β and in...
Source: Cellular and Molecular Immunology - October 23, 2019 Category: Molecular Biology Authors: Sun X, Hou T, Cheung E, Iu TN, Tam VW, Chu IM, Tsang MS, Chan PK, Lam CW, Wong CK Tags: Cell Mol Immunol Source Type: research

Dissecting the theranostic potential of exosomes in autoimmune disorders.
PMID: 31619771 [PubMed - as supplied by publisher] (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - October 16, 2019 Category: Molecular Biology Authors: Jayaseelan VP, Arumugam P Tags: Cell Mol Immunol Source Type: research

Tumor-expressed B7-H3 mediates the inhibition of antitumor T-cell functions in ovarian cancer insensitive to PD-1 blockade therapy.
Abstract Although PD-L1/PD-1 blockade therapy has been approved to treat many types of cancers, the majority of patients with solid tumors do not respond well, but the underlying reason remains unclear. Here, we studied ovarian cancer (OvCa), a tumor type generally resistant to current immunotherapies, to investigate PD-1-independent immunosuppression. We found that PD-L1 was not highly expressed in the tumor microenvironment (TME) of human OvCa. Instead, B7-H3, another checkpoint molecule, was highly expressed by both tumor cells and tumor-infiltrating antigen-presenting cells (APCs), which correlated with T...
Source: Cellular and Molecular Immunology - October 14, 2019 Category: Molecular Biology Authors: Cai D, Li J, Liu D, Hong S, Qiao Q, Sun Q, Li P, Lyu N, Sun T, Xie S, Guo L, Ni L, Jin L, Dong C Tags: Cell Mol Immunol Source Type: research