The E3 ubiquitin ligase TRAF6 controls CTLA-4 turnover and promotes T-cell-mediated antitumor immunity
Cell Mol Immunol. 2023 Dec 11. doi: 10.1038/s41423-023-01105-x. Online ahead of print.NO ABSTRACTPMID:38082145 | DOI:10.1038/s41423-023-01105-x (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - December 11, 2023 Category: Molecular Biology Authors: Xiao-Liang Jie Hua Guo Guang-Biao Zhou Source Type: research
RIPK1 plays a crucial role in maintaining regulatory T-Cell homeostasis by inhibiting both RIPK3- and FADD-mediated cell death
Cell Mol Immunol. 2023 Dec 11. doi: 10.1038/s41423-023-01113-x. Online ahead of print.ABSTRACTRegulatory T (Treg) cells play an essential role in maintaining immune balance across various physiological and pathological conditions. However, the mechanisms underlying Treg homeostasis remain incompletely understood. Here, we report that RIPK1 is crucial for Treg cell survival and homeostasis. We generated mice with Treg cell-specific ablation of Ripk1 and found that these mice developed fatal systemic autoimmunity due to a dramatic reduction in the Treg cell compartment caused by excessive cell death. Unlike conventional T ce...
Source: Cellular and Molecular Immunology - December 11, 2023 Category: Molecular Biology Authors: Xiaoxue Deng Lingxia Wang Yunze Zhai Qiuyue Liu Fengxue Du Yu Zhang Wenxing Zhao Tingtao Wu Yiwen Tao Jie Deng Yongbing Cao Pei Hao Jiazi Ren Yunli Shen Zuoren Yu Yuejuan Zheng Haibing Zhang Haikun Wang Source Type: research
Oxidative stress-initiated one-carbon metabolism drives the generation of interleukin-10-producing B cells to resolve pneumonia
Cell Mol Immunol. 2023 Dec 11. doi: 10.1038/s41423-023-01109-7. Online ahead of print.ABSTRACTThe metabolic reprogramming underlying the generation of regulatory B cells during infectious diseases remains unknown. Using a Pseudomonas aeruginosa-induced pneumonia model, we reported that IL-10-producing B cells (IL-10+ B cells) play a key role in spontaneously resolving infection-mediated inflammation. Accumulated cytosolic reactive oxygen species (ROS) during inflammation were shown to drive IL-10+ B-cell generation by remodeling one-carbon metabolism. Depletion of the enzyme serine hydroxymethyltransferase 1 (Shmt1) led to...
Source: Cellular and Molecular Immunology - December 11, 2023 Category: Molecular Biology Authors: Ying Fu Baichao Yu Qi Wang Zhou Lu Hushan Zhang Dan Zhang Feifei Luo Ronghua Liu Luman Wang Yiwei Chu Source Type: research
The E3 ubiquitin ligase TRAF6 controls CTLA-4 turnover and promotes T-cell-mediated antitumor immunity
Cell Mol Immunol. 2023 Dec 11. doi: 10.1038/s41423-023-01105-x. Online ahead of print.NO ABSTRACTPMID:38082145 | DOI:10.1038/s41423-023-01105-x (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - December 11, 2023 Category: Molecular Biology Authors: Xiao-Liang Jie Hua Guo Guang-Biao Zhou Source Type: research
RIPK1 plays a crucial role in maintaining regulatory T-Cell homeostasis by inhibiting both RIPK3- and FADD-mediated cell death
Cell Mol Immunol. 2023 Dec 11. doi: 10.1038/s41423-023-01113-x. Online ahead of print.ABSTRACTRegulatory T (Treg) cells play an essential role in maintaining immune balance across various physiological and pathological conditions. However, the mechanisms underlying Treg homeostasis remain incompletely understood. Here, we report that RIPK1 is crucial for Treg cell survival and homeostasis. We generated mice with Treg cell-specific ablation of Ripk1 and found that these mice developed fatal systemic autoimmunity due to a dramatic reduction in the Treg cell compartment caused by excessive cell death. Unlike conventional T ce...
Source: Cellular and Molecular Immunology - December 11, 2023 Category: Molecular Biology Authors: Xiaoxue Deng Lingxia Wang Yunze Zhai Qiuyue Liu Fengxue Du Yu Zhang Wenxing Zhao Tingtao Wu Yiwen Tao Jie Deng Yongbing Cao Pei Hao Jiazi Ren Yunli Shen Zuoren Yu Yuejuan Zheng Haibing Zhang Haikun Wang Source Type: research
Oxidative stress-initiated one-carbon metabolism drives the generation of interleukin-10-producing B cells to resolve pneumonia
Cell Mol Immunol. 2023 Dec 11. doi: 10.1038/s41423-023-01109-7. Online ahead of print.ABSTRACTThe metabolic reprogramming underlying the generation of regulatory B cells during infectious diseases remains unknown. Using a Pseudomonas aeruginosa-induced pneumonia model, we reported that IL-10-producing B cells (IL-10+ B cells) play a key role in spontaneously resolving infection-mediated inflammation. Accumulated cytosolic reactive oxygen species (ROS) during inflammation were shown to drive IL-10+ B-cell generation by remodeling one-carbon metabolism. Depletion of the enzyme serine hydroxymethyltransferase 1 (Shmt1) led to...
Source: Cellular and Molecular Immunology - December 11, 2023 Category: Molecular Biology Authors: Ying Fu Baichao Yu Qi Wang Zhou Lu Hushan Zhang Dan Zhang Feifei Luo Ronghua Liu Luman Wang Yiwei Chu Source Type: research
The E3 ubiquitin ligase TRAF6 controls CTLA-4 turnover and promotes T-cell-mediated antitumor immunity
Cell Mol Immunol. 2023 Dec 11. doi: 10.1038/s41423-023-01105-x. Online ahead of print.NO ABSTRACTPMID:38082145 | DOI:10.1038/s41423-023-01105-x (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - December 11, 2023 Category: Molecular Biology Authors: Xiao-Liang Jie Hua Guo Guang-Biao Zhou Source Type: research
RIPK1 plays a crucial role in maintaining regulatory T-Cell homeostasis by inhibiting both RIPK3- and FADD-mediated cell death
Cell Mol Immunol. 2023 Dec 11. doi: 10.1038/s41423-023-01113-x. Online ahead of print.ABSTRACTRegulatory T (Treg) cells play an essential role in maintaining immune balance across various physiological and pathological conditions. However, the mechanisms underlying Treg homeostasis remain incompletely understood. Here, we report that RIPK1 is crucial for Treg cell survival and homeostasis. We generated mice with Treg cell-specific ablation of Ripk1 and found that these mice developed fatal systemic autoimmunity due to a dramatic reduction in the Treg cell compartment caused by excessive cell death. Unlike conventional T ce...
Source: Cellular and Molecular Immunology - December 11, 2023 Category: Molecular Biology Authors: Xiaoxue Deng Lingxia Wang Yunze Zhai Qiuyue Liu Fengxue Du Yu Zhang Wenxing Zhao Tingtao Wu Yiwen Tao Jie Deng Yongbing Cao Pei Hao Jiazi Ren Yunli Shen Zuoren Yu Yuejuan Zheng Haibing Zhang Haikun Wang Source Type: research
Oxidative stress-initiated one-carbon metabolism drives the generation of interleukin-10-producing B cells to resolve pneumonia
Cell Mol Immunol. 2023 Dec 11. doi: 10.1038/s41423-023-01109-7. Online ahead of print.ABSTRACTThe metabolic reprogramming underlying the generation of regulatory B cells during infectious diseases remains unknown. Using a Pseudomonas aeruginosa-induced pneumonia model, we reported that IL-10-producing B cells (IL-10+ B cells) play a key role in spontaneously resolving infection-mediated inflammation. Accumulated cytosolic reactive oxygen species (ROS) during inflammation were shown to drive IL-10+ B-cell generation by remodeling one-carbon metabolism. Depletion of the enzyme serine hydroxymethyltransferase 1 (Shmt1) led to...
Source: Cellular and Molecular Immunology - December 11, 2023 Category: Molecular Biology Authors: Ying Fu Baichao Yu Qi Wang Zhou Lu Hushan Zhang Dan Zhang Feifei Luo Ronghua Liu Luman Wang Yiwei Chu Source Type: research
The E3 ubiquitin ligase TRAF6 controls CTLA-4 turnover and promotes T-cell-mediated antitumor immunity
Cell Mol Immunol. 2023 Dec 11. doi: 10.1038/s41423-023-01105-x. Online ahead of print.NO ABSTRACTPMID:38082145 | DOI:10.1038/s41423-023-01105-x (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - December 11, 2023 Category: Molecular Biology Authors: Xiao-Liang Jie Hua Guo Guang-Biao Zhou Source Type: research
RIPK1 plays a crucial role in maintaining regulatory T-Cell homeostasis by inhibiting both RIPK3- and FADD-mediated cell death
Cell Mol Immunol. 2023 Dec 11. doi: 10.1038/s41423-023-01113-x. Online ahead of print.ABSTRACTRegulatory T (Treg) cells play an essential role in maintaining immune balance across various physiological and pathological conditions. However, the mechanisms underlying Treg homeostasis remain incompletely understood. Here, we report that RIPK1 is crucial for Treg cell survival and homeostasis. We generated mice with Treg cell-specific ablation of Ripk1 and found that these mice developed fatal systemic autoimmunity due to a dramatic reduction in the Treg cell compartment caused by excessive cell death. Unlike conventional T ce...
Source: Cellular and Molecular Immunology - December 11, 2023 Category: Molecular Biology Authors: Xiaoxue Deng Lingxia Wang Yunze Zhai Qiuyue Liu Fengxue Du Yu Zhang Wenxing Zhao Tingtao Wu Yiwen Tao Jie Deng Yongbing Cao Pei Hao Jiazi Ren Yunli Shen Zuoren Yu Yuejuan Zheng Haibing Zhang Haikun Wang Source Type: research
Oxidative stress-initiated one-carbon metabolism drives the generation of interleukin-10-producing B cells to resolve pneumonia
Cell Mol Immunol. 2023 Dec 11. doi: 10.1038/s41423-023-01109-7. Online ahead of print.ABSTRACTThe metabolic reprogramming underlying the generation of regulatory B cells during infectious diseases remains unknown. Using a Pseudomonas aeruginosa-induced pneumonia model, we reported that IL-10-producing B cells (IL-10+ B cells) play a key role in spontaneously resolving infection-mediated inflammation. Accumulated cytosolic reactive oxygen species (ROS) during inflammation were shown to drive IL-10+ B-cell generation by remodeling one-carbon metabolism. Depletion of the enzyme serine hydroxymethyltransferase 1 (Shmt1) led to...
Source: Cellular and Molecular Immunology - December 11, 2023 Category: Molecular Biology Authors: Ying Fu Baichao Yu Qi Wang Zhou Lu Hushan Zhang Dan Zhang Feifei Luo Ronghua Liu Luman Wang Yiwei Chu Source Type: research
The E3 ubiquitin ligase TRAF6 controls CTLA-4 turnover and promotes T-cell-mediated antitumor immunity
Cell Mol Immunol. 2023 Dec 11. doi: 10.1038/s41423-023-01105-x. Online ahead of print.NO ABSTRACTPMID:38082145 | DOI:10.1038/s41423-023-01105-x (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - December 11, 2023 Category: Molecular Biology Authors: Xiao-Liang Jie Hua Guo Guang-Biao Zhou Source Type: research
RIPK1 plays a crucial role in maintaining regulatory T-Cell homeostasis by inhibiting both RIPK3- and FADD-mediated cell death
Cell Mol Immunol. 2023 Dec 11. doi: 10.1038/s41423-023-01113-x. Online ahead of print.ABSTRACTRegulatory T (Treg) cells play an essential role in maintaining immune balance across various physiological and pathological conditions. However, the mechanisms underlying Treg homeostasis remain incompletely understood. Here, we report that RIPK1 is crucial for Treg cell survival and homeostasis. We generated mice with Treg cell-specific ablation of Ripk1 and found that these mice developed fatal systemic autoimmunity due to a dramatic reduction in the Treg cell compartment caused by excessive cell death. Unlike conventional T ce...
Source: Cellular and Molecular Immunology - December 11, 2023 Category: Molecular Biology Authors: Xiaoxue Deng Lingxia Wang Yunze Zhai Qiuyue Liu Fengxue Du Yu Zhang Wenxing Zhao Tingtao Wu Yiwen Tao Jie Deng Yongbing Cao Pei Hao Jiazi Ren Yunli Shen Zuoren Yu Yuejuan Zheng Haibing Zhang Haikun Wang Source Type: research
Oxidative stress-initiated one-carbon metabolism drives the generation of interleukin-10-producing B cells to resolve pneumonia
Cell Mol Immunol. 2023 Dec 11. doi: 10.1038/s41423-023-01109-7. Online ahead of print.ABSTRACTThe metabolic reprogramming underlying the generation of regulatory B cells during infectious diseases remains unknown. Using a Pseudomonas aeruginosa-induced pneumonia model, we reported that IL-10-producing B cells (IL-10+ B cells) play a key role in spontaneously resolving infection-mediated inflammation. Accumulated cytosolic reactive oxygen species (ROS) during inflammation were shown to drive IL-10+ B-cell generation by remodeling one-carbon metabolism. Depletion of the enzyme serine hydroxymethyltransferase 1 (Shmt1) led to...
Source: Cellular and Molecular Immunology - December 11, 2023 Category: Molecular Biology Authors: Ying Fu Baichao Yu Qi Wang Zhou Lu Hushan Zhang Dan Zhang Feifei Luo Ronghua Liu Luman Wang Yiwei Chu Source Type: research
