Regulation of CD8 < sup > + < /sup > T memory and exhaustion by the mTOR signals
Cell Mol Immunol. 2023 Aug 15. doi: 10.1038/s41423-023-01064-3. Online ahead of print.ABSTRACTCD8+ T cells are the key executioners of the adaptive immune arm, which mediates antitumor and antiviral immunity. Naïve CD8+ T cells develop in the thymus and are quickly activated in the periphery after encountering a cognate antigen, which induces these cells to proliferate and differentiate into effector cells that fight the initial infection. Simultaneously, a fraction of these cells become long-lived memory CD8+ T cells that combat future infections. Notably, the generation and maintenance of memory cells is profoundly affe...
Source: Cellular and Molecular Immunology - August 15, 2023 Category: Molecular Biology Authors: Yao Chen Ziyang Xu Hongxiang Sun Xinxing Ouyang Yuhen Han Haihui Yu Ningbo Wu Yiting Xie Bing Su Source Type: research
NAD < sup > + < /sup > salvage governs the immunosuppressive capacity of mesenchymal stem cells
This study demonstrated that unlike its proinflammatory role in immune cells, NAD+ metabolism governs the anti-inflammatory function of MSCs during inflammation.PMID:37580400 | DOI:10.1038/s41423-023-01073-2 (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - August 14, 2023 Category: Molecular Biology Authors: Jiankai Fang Pengbo Hou Shisong Liu Muqiu Zuo Zhanhong Liu Wangwang Chen Yuyi Han Yanan Li Tingting Wang Chao Feng Peishan Li Changshun Shao Yufang Shi Source Type: research
NAD < sup > + < /sup > salvage governs the immunosuppressive capacity of mesenchymal stem cells
This study demonstrated that unlike its proinflammatory role in immune cells, NAD+ metabolism governs the anti-inflammatory function of MSCs during inflammation.PMID:37580400 | DOI:10.1038/s41423-023-01073-2 (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - August 14, 2023 Category: Molecular Biology Authors: Jiankai Fang Pengbo Hou Shisong Liu Muqiu Zuo Zhanhong Liu Wangwang Chen Yuyi Han Yanan Li Tingting Wang Chao Feng Peishan Li Changshun Shao Yufang Shi Source Type: research
The TNF α/TNFR2 axis mediates natural killer cell proliferation by promoting aerobic glycolysis
Cell Mol Immunol. 2023 Aug 9. doi: 10.1038/s41423-023-01071-4. Online ahead of print.ABSTRACTNatural killer (NK) cells are predominant innate lymphocytes that initiate the early immune response during infection. NK cells undergo a metabolic switch to fuel augmented proliferation and activation following infection. Tumor necrosis factor-alpha (TNFα) is a well-known inflammatory cytokine that enhances NK cell function; however, the mechanism underlying NK cell proliferation in response to TNFα is not well established. Here, we demonstrated that upon infection/inflammation, NK cells upregulate the expression of TNF receptor...
Source: Cellular and Molecular Immunology - August 8, 2023 Category: Molecular Biology Authors: Abrar Ul Haq Khan Alaa Kassim Ali Bryan Marr Donghyeon Jo Simin Ahmadvand Claire Fong-McMaster Saeedah Musaed Almutairi Lisheng Wang Subash Sad Mary-Ellen Harper Seung-Hwan Lee Source Type: research
Glycogen synthase kinase 3 controls T-cell exhaustion by regulating NFAT activation
Cell Mol Immunol. 2023 Aug 9. doi: 10.1038/s41423-023-01075-0. Online ahead of print.ABSTRACTCellular immunity mediated by CD8+ T cells plays an indispensable role in bacterial and viral clearance and cancers. However, persistent antigen stimulation of CD8+ T cells leads to an exhausted or dysfunctional cellular state characterized by the loss of effector function and high expression of inhibitory receptors during chronic viral infection and in tumors. Numerous studies have shown that glycogen synthase kinase 3 (GSK3) controls the function and development of immune cells, but whether GSK3 affects CD8+ T cells is not clearl...
Source: Cellular and Molecular Immunology - August 8, 2023 Category: Molecular Biology Authors: Yubing Fu Jinjia Wang Chenfeng Liu Kunyu Liao Xianjun Gao Ronghan Tang Binbin Fan Yazhen Hong Nengming Xiao Changchun Xiao Wen-Hsien Liu Source Type: research
