cFLIP < sub > S < /sub > regulates alternative NLRP3 inflammasome activation in human monocytes
Cell Mol Immunol. 2023 Aug 17. doi: 10.1038/s41423-023-01077-y. Online ahead of print.ABSTRACTThe innate immune responses, including inflammasome activation, are paramount for host defense against pathogen infection. In contrast to canonical and noncanonical inflammasome activation, in this study, heat-killed gram-negative bacteria (HK bacteria) were identified as single-step stimulators of the NLRP3 inflammasome in human monocytes, and they caused a moderate amount of IL-1β to be released from cells. Time course experiments showed that this alternative inflammasome response was finished within a few hours. Further analys...
Source: Cellular and Molecular Immunology - August 17, 2023 Category: Molecular Biology Authors: Yuhui Gao Shi Yu Mengdan Chen Xun Wang Lei Pan Bin Wei Guangxun Meng Source Type: research
cFLIP < sub > S < /sub > regulates alternative NLRP3 inflammasome activation in human monocytes
Cell Mol Immunol. 2023 Aug 17. doi: 10.1038/s41423-023-01077-y. Online ahead of print.ABSTRACTThe innate immune responses, including inflammasome activation, are paramount for host defense against pathogen infection. In contrast to canonical and noncanonical inflammasome activation, in this study, heat-killed gram-negative bacteria (HK bacteria) were identified as single-step stimulators of the NLRP3 inflammasome in human monocytes, and they caused a moderate amount of IL-1β to be released from cells. Time course experiments showed that this alternative inflammasome response was finished within a few hours. Further analys...
Source: Cellular and Molecular Immunology - August 17, 2023 Category: Molecular Biology Authors: Yuhui Gao Shi Yu Mengdan Chen Xun Wang Lei Pan Bin Wei Guangxun Meng Source Type: research
cFLIP < sub > S < /sub > regulates alternative NLRP3 inflammasome activation in human monocytes
Cell Mol Immunol. 2023 Aug 17. doi: 10.1038/s41423-023-01077-y. Online ahead of print.ABSTRACTThe innate immune responses, including inflammasome activation, are paramount for host defense against pathogen infection. In contrast to canonical and noncanonical inflammasome activation, in this study, heat-killed gram-negative bacteria (HK bacteria) were identified as single-step stimulators of the NLRP3 inflammasome in human monocytes, and they caused a moderate amount of IL-1β to be released from cells. Time course experiments showed that this alternative inflammasome response was finished within a few hours. Further analys...
Source: Cellular and Molecular Immunology - August 17, 2023 Category: Molecular Biology Authors: Yuhui Gao Shi Yu Mengdan Chen Xun Wang Lei Pan Bin Wei Guangxun Meng Source Type: research
Vitamin B-reath easier: vitamin B6 derivatives reduce IL-33 to limit lung inflammation
Cell Mol Immunol. 2023 Aug 16. doi: 10.1038/s41423-023-01076-z. Online ahead of print.NO ABSTRACTPMID:37587227 | DOI:10.1038/s41423-023-01076-z (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - August 16, 2023 Category: Molecular Biology Authors: H ēth R Turnquist Source Type: research
Vitamin B-reath easier: vitamin B6 derivatives reduce IL-33 to limit lung inflammation
Cell Mol Immunol. 2023 Aug 16. doi: 10.1038/s41423-023-01076-z. Online ahead of print.NO ABSTRACTPMID:37587227 | DOI:10.1038/s41423-023-01076-z (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - August 16, 2023 Category: Molecular Biology Authors: H ēth R Turnquist Source Type: research
MAVS-loaded unanchored Lys63-linked polyubiquitin chains activate the RIG-I-MAVS signaling cascade
Cell Mol Immunol. 2023 Aug 15. doi: 10.1038/s41423-023-01065-2. Online ahead of print.ABSTRACTThe adaptor molecule MAVS forms prion-like aggregates to govern the RIG-I-like receptor (RLR) signaling cascade. Lys63 (K63)-linked polyubiquitination is critical for MAVS aggregation, yet the underlying mechanism and the corresponding E3 ligases and deubiquitinating enzymes (DUBs) remain elusive. Here, we found that the K63-linked polyubiquitin chains loaded on MAVS can be directly recognized by RIG-I to initiate RIG-I-mediated MAVS aggregation with the prerequisite of the CARDRIG-I-CARDMAVS interaction. Interestingly, many K63-l...
Source: Cellular and Molecular Immunology - August 15, 2023 Category: Molecular Biology Authors: Feng Liu Wanxin Zhuang Bin Song Yuan Yang Junqi Liu Yi Zheng Bingyu Liu Jie Zheng Wei Zhao Chengjiang Gao Source Type: research
Immune regulatory networks coordinated by glycans and glycan-binding proteins in autoimmunity and infection
Cell Mol Immunol. 2023 Aug 15. doi: 10.1038/s41423-023-01074-1. Online ahead of print.ABSTRACTThe immune system is coordinated by an intricate network of stimulatory and inhibitory circuits that regulate host responses against endogenous and exogenous insults. Disruption of these safeguard and homeostatic mechanisms can lead to unpredictable inflammatory and autoimmune responses, whereas deficiency of immune stimulatory pathways may orchestrate immunosuppressive programs that contribute to perpetuate chronic infections, but also influence cancer development and progression. Glycans have emerged as essential components of h...
Source: Cellular and Molecular Immunology - August 15, 2023 Category: Molecular Biology Authors: Salom é S Pinho In ês Alves Joana Gaifem Gabriel A Rabinovich Source Type: research
Regulation of CD8 < sup > + < /sup > T memory and exhaustion by the mTOR signals
Cell Mol Immunol. 2023 Aug 15. doi: 10.1038/s41423-023-01064-3. Online ahead of print.ABSTRACTCD8+ T cells are the key executioners of the adaptive immune arm, which mediates antitumor and antiviral immunity. Naïve CD8+ T cells develop in the thymus and are quickly activated in the periphery after encountering a cognate antigen, which induces these cells to proliferate and differentiate into effector cells that fight the initial infection. Simultaneously, a fraction of these cells become long-lived memory CD8+ T cells that combat future infections. Notably, the generation and maintenance of memory cells is profoundly affe...
Source: Cellular and Molecular Immunology - August 15, 2023 Category: Molecular Biology Authors: Yao Chen Ziyang Xu Hongxiang Sun Xinxing Ouyang Yuhen Han Haihui Yu Ningbo Wu Yiting Xie Bing Su Source Type: research
MAVS-loaded unanchored Lys63-linked polyubiquitin chains activate the RIG-I-MAVS signaling cascade
Cell Mol Immunol. 2023 Aug 15. doi: 10.1038/s41423-023-01065-2. Online ahead of print.ABSTRACTThe adaptor molecule MAVS forms prion-like aggregates to govern the RIG-I-like receptor (RLR) signaling cascade. Lys63 (K63)-linked polyubiquitination is critical for MAVS aggregation, yet the underlying mechanism and the corresponding E3 ligases and deubiquitinating enzymes (DUBs) remain elusive. Here, we found that the K63-linked polyubiquitin chains loaded on MAVS can be directly recognized by RIG-I to initiate RIG-I-mediated MAVS aggregation with the prerequisite of the CARDRIG-I-CARDMAVS interaction. Interestingly, many K63-l...
Source: Cellular and Molecular Immunology - August 15, 2023 Category: Molecular Biology Authors: Feng Liu Wanxin Zhuang Bin Song Yuan Yang Junqi Liu Yi Zheng Bingyu Liu Jie Zheng Wei Zhao Chengjiang Gao Source Type: research
Immune regulatory networks coordinated by glycans and glycan-binding proteins in autoimmunity and infection
Cell Mol Immunol. 2023 Aug 15. doi: 10.1038/s41423-023-01074-1. Online ahead of print.ABSTRACTThe immune system is coordinated by an intricate network of stimulatory and inhibitory circuits that regulate host responses against endogenous and exogenous insults. Disruption of these safeguard and homeostatic mechanisms can lead to unpredictable inflammatory and autoimmune responses, whereas deficiency of immune stimulatory pathways may orchestrate immunosuppressive programs that contribute to perpetuate chronic infections, but also influence cancer development and progression. Glycans have emerged as essential components of h...
Source: Cellular and Molecular Immunology - August 15, 2023 Category: Molecular Biology Authors: Salom é S Pinho In ês Alves Joana Gaifem Gabriel A Rabinovich Source Type: research
Regulation of CD8 < sup > + < /sup > T memory and exhaustion by the mTOR signals
Cell Mol Immunol. 2023 Aug 15. doi: 10.1038/s41423-023-01064-3. Online ahead of print.ABSTRACTCD8+ T cells are the key executioners of the adaptive immune arm, which mediates antitumor and antiviral immunity. Naïve CD8+ T cells develop in the thymus and are quickly activated in the periphery after encountering a cognate antigen, which induces these cells to proliferate and differentiate into effector cells that fight the initial infection. Simultaneously, a fraction of these cells become long-lived memory CD8+ T cells that combat future infections. Notably, the generation and maintenance of memory cells is profoundly affe...
Source: Cellular and Molecular Immunology - August 15, 2023 Category: Molecular Biology Authors: Yao Chen Ziyang Xu Hongxiang Sun Xinxing Ouyang Yuhen Han Haihui Yu Ningbo Wu Yiting Xie Bing Su Source Type: research
NAD < sup > + < /sup > salvage governs the immunosuppressive capacity of mesenchymal stem cells
This study demonstrated that unlike its proinflammatory role in immune cells, NAD+ metabolism governs the anti-inflammatory function of MSCs during inflammation.PMID:37580400 | DOI:10.1038/s41423-023-01073-2 (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - August 14, 2023 Category: Molecular Biology Authors: Jiankai Fang Pengbo Hou Shisong Liu Muqiu Zuo Zhanhong Liu Wangwang Chen Yuyi Han Yanan Li Tingting Wang Chao Feng Peishan Li Changshun Shao Yufang Shi Source Type: research
NAD < sup > + < /sup > salvage governs the immunosuppressive capacity of mesenchymal stem cells
This study demonstrated that unlike its proinflammatory role in immune cells, NAD+ metabolism governs the anti-inflammatory function of MSCs during inflammation.PMID:37580400 | DOI:10.1038/s41423-023-01073-2 (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - August 14, 2023 Category: Molecular Biology Authors: Jiankai Fang Pengbo Hou Shisong Liu Muqiu Zuo Zhanhong Liu Wangwang Chen Yuyi Han Yanan Li Tingting Wang Chao Feng Peishan Li Changshun Shao Yufang Shi Source Type: research
The TNF α/TNFR2 axis mediates natural killer cell proliferation by promoting aerobic glycolysis
Cell Mol Immunol. 2023 Aug 9. doi: 10.1038/s41423-023-01071-4. Online ahead of print.ABSTRACTNatural killer (NK) cells are predominant innate lymphocytes that initiate the early immune response during infection. NK cells undergo a metabolic switch to fuel augmented proliferation and activation following infection. Tumor necrosis factor-alpha (TNFα) is a well-known inflammatory cytokine that enhances NK cell function; however, the mechanism underlying NK cell proliferation in response to TNFα is not well established. Here, we demonstrated that upon infection/inflammation, NK cells upregulate the expression of TNF receptor...
Source: Cellular and Molecular Immunology - August 8, 2023 Category: Molecular Biology Authors: Abrar Ul Haq Khan Alaa Kassim Ali Bryan Marr Donghyeon Jo Simin Ahmadvand Claire Fong-McMaster Saeedah Musaed Almutairi Lisheng Wang Subash Sad Mary-Ellen Harper Seung-Hwan Lee Source Type: research
Glycogen synthase kinase 3 controls T-cell exhaustion by regulating NFAT activation
Cell Mol Immunol. 2023 Aug 9. doi: 10.1038/s41423-023-01075-0. Online ahead of print.ABSTRACTCellular immunity mediated by CD8+ T cells plays an indispensable role in bacterial and viral clearance and cancers. However, persistent antigen stimulation of CD8+ T cells leads to an exhausted or dysfunctional cellular state characterized by the loss of effector function and high expression of inhibitory receptors during chronic viral infection and in tumors. Numerous studies have shown that glycogen synthase kinase 3 (GSK3) controls the function and development of immune cells, but whether GSK3 affects CD8+ T cells is not clearl...
Source: Cellular and Molecular Immunology - August 8, 2023 Category: Molecular Biology Authors: Yubing Fu Jinjia Wang Chenfeng Liu Kunyu Liao Xianjun Gao Ronghan Tang Binbin Fan Yazhen Hong Nengming Xiao Changchun Xiao Wen-Hsien Liu Source Type: research
