Silent battles: immune responses in asymptomatic SARS-CoV-2 infection
Cell Mol Immunol. 2024 Feb;21(2):159-170. doi: 10.1038/s41423-024-01127-z. Epub 2024 Jan 15.ABSTRACTSARS-CoV-2 infections manifest with a broad spectrum of presentations, ranging from asymptomatic infections to severe pneumonia and fatal outcomes. This review centers on asymptomatic infections, a widely reported phenomenon that has substantially contributed to the rapid spread of the pandemic. In such asymptomatic infections, we focus on the role of innate, humoral, and cellular immunity. Notably, asymptomatic infections are characterized by an early and robust innate immune response, particularly a swift type 1 IFN reacti...
Source: Cellular and Molecular Immunology - January 14, 2024 Category: Molecular Biology Authors: Nina Le Bert Taraz Samandari Source Type: research
Nuclear receptor coactivator 6 is a critical regulator of NLRP3 inflammasome activation and gouty arthritis
Cell Mol Immunol. 2024 Jan 10. doi: 10.1038/s41423-023-01121-x. Online ahead of print.ABSTRACTTranscriptional coactivators regulate the rate of gene expression in the nucleus. Nuclear receptor coactivator 6 (NCOA6), a coactivator, has been implicated in embryonic development, metabolism, and cancer pathogenesis, but its role in innate immunity and inflammatory diseases remains unclear. Here, we demonstrated that NCOA6 was expressed in monocytes and macrophages and that its level was increased under proinflammatory conditions. Unexpectedly, nuclear NCOA6 was found to translocate to the cytoplasm in activated monocytes and t...
Source: Cellular and Molecular Immunology - January 10, 2024 Category: Molecular Biology Authors: Kang-Gu Lee Bong-Ki Hong Saseong Lee Naeun Lee Seung-Whan Kim Donghyun Kim Wan-Uk Kim Source Type: research
Nuclear receptor coactivator 6 is a critical regulator of NLRP3 inflammasome activation and gouty arthritis
Cell Mol Immunol. 2024 Jan 10. doi: 10.1038/s41423-023-01121-x. Online ahead of print.ABSTRACTTranscriptional coactivators regulate the rate of gene expression in the nucleus. Nuclear receptor coactivator 6 (NCOA6), a coactivator, has been implicated in embryonic development, metabolism, and cancer pathogenesis, but its role in innate immunity and inflammatory diseases remains unclear. Here, we demonstrated that NCOA6 was expressed in monocytes and macrophages and that its level was increased under proinflammatory conditions. Unexpectedly, nuclear NCOA6 was found to translocate to the cytoplasm in activated monocytes and t...
Source: Cellular and Molecular Immunology - January 10, 2024 Category: Molecular Biology Authors: Kang-Gu Lee Bong-Ki Hong Saseong Lee Naeun Lee Seung-Whan Kim Donghyun Kim Wan-Uk Kim Source Type: research
ROS-induced metabolic reprogramming to one-carbon metabolism and S-adenosylmethionine-mediated epigenetic modification in IL-10-producing B cells for the resolution of pneumonia
Cell Mol Immunol. 2024 Jan 4. doi: 10.1038/s41423-023-01117-7. Online ahead of print.NO ABSTRACTPMID:38177244 | DOI:10.1038/s41423-023-01117-7 (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - January 4, 2024 Category: Molecular Biology Authors: Sujin Lee Tae Jin Kim Source Type: research
SMAD7 expression in CAR-T cells improves persistence and safety for solid tumors
Cell Mol Immunol. 2024 Jan 4. doi: 10.1038/s41423-023-01120-y. Online ahead of print.ABSTRACTDespite the tremendous progress of chimeric antigen receptor T (CAR-T) cell therapy in hematological malignancies, their application in solid tumors has been limited largely due to T-cell exhaustion in the tumor microenvironment (TME) and systemic toxicity caused by excessive cytokine release. As a key regulator of the immunosuppressive TME, TGF-β promotes cytokine synthesis via the NF-κB pathway. Here, we coexpressed SMAD7, a suppressor of TGF-β signaling, with a HER2-targeted CAR in engineered T cells. These novel CAR-T cells ...
Source: Cellular and Molecular Immunology - January 4, 2024 Category: Molecular Biology Authors: Sixin Liang Rui Zheng Baile Zuo Jia Li Yiyi Wang Yujie Han Hao Dong Xiaojuan Zhao Yiting Zhang Pengju Wang Ruotong Meng Lintao Jia Angang Yang Bo Yan Source Type: research
ROS-induced metabolic reprogramming to one-carbon metabolism and S-adenosylmethionine-mediated epigenetic modification in IL-10-producing B cells for the resolution of pneumonia
Cell Mol Immunol. 2024 Jan 4. doi: 10.1038/s41423-023-01117-7. Online ahead of print.NO ABSTRACTPMID:38177244 | DOI:10.1038/s41423-023-01117-7 (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - January 4, 2024 Category: Molecular Biology Authors: Sujin Lee Tae Jin Kim Source Type: research
SMAD7 expression in CAR-T cells improves persistence and safety for solid tumors
Cell Mol Immunol. 2024 Jan 4. doi: 10.1038/s41423-023-01120-y. Online ahead of print.ABSTRACTDespite the tremendous progress of chimeric antigen receptor T (CAR-T) cell therapy in hematological malignancies, their application in solid tumors has been limited largely due to T-cell exhaustion in the tumor microenvironment (TME) and systemic toxicity caused by excessive cytokine release. As a key regulator of the immunosuppressive TME, TGF-β promotes cytokine synthesis via the NF-κB pathway. Here, we coexpressed SMAD7, a suppressor of TGF-β signaling, with a HER2-targeted CAR in engineered T cells. These novel CAR-T cells ...
Source: Cellular and Molecular Immunology - January 4, 2024 Category: Molecular Biology Authors: Sixin Liang Rui Zheng Baile Zuo Jia Li Yiyi Wang Yujie Han Hao Dong Xiaojuan Zhao Yiting Zhang Pengju Wang Ruotong Meng Lintao Jia Angang Yang Bo Yan Source Type: research
ROS-induced metabolic reprogramming to one-carbon metabolism and S-adenosylmethionine-mediated epigenetic modification in IL-10-producing B cells for the resolution of pneumonia
Cell Mol Immunol. 2024 Jan 4. doi: 10.1038/s41423-023-01117-7. Online ahead of print.NO ABSTRACTPMID:38177244 | DOI:10.1038/s41423-023-01117-7 (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - January 4, 2024 Category: Molecular Biology Authors: Sujin Lee Tae Jin Kim Source Type: research
SMAD7 expression in CAR-T cells improves persistence and safety for solid tumors
Cell Mol Immunol. 2024 Jan 4. doi: 10.1038/s41423-023-01120-y. Online ahead of print.ABSTRACTDespite the tremendous progress of chimeric antigen receptor T (CAR-T) cell therapy in hematological malignancies, their application in solid tumors has been limited largely due to T-cell exhaustion in the tumor microenvironment (TME) and systemic toxicity caused by excessive cytokine release. As a key regulator of the immunosuppressive TME, TGF-β promotes cytokine synthesis via the NF-κB pathway. Here, we coexpressed SMAD7, a suppressor of TGF-β signaling, with a HER2-targeted CAR in engineered T cells. These novel CAR-T cells ...
Source: Cellular and Molecular Immunology - January 4, 2024 Category: Molecular Biology Authors: Sixin Liang Rui Zheng Baile Zuo Jia Li Yiyi Wang Yujie Han Hao Dong Xiaojuan Zhao Yiting Zhang Pengju Wang Ruotong Meng Lintao Jia Angang Yang Bo Yan Source Type: research
ROS-induced metabolic reprogramming to one-carbon metabolism and S-adenosylmethionine-mediated epigenetic modification in IL-10-producing B cells for the resolution of pneumonia
Cell Mol Immunol. 2024 Jan 4. doi: 10.1038/s41423-023-01117-7. Online ahead of print.NO ABSTRACTPMID:38177244 | DOI:10.1038/s41423-023-01117-7 (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - January 4, 2024 Category: Molecular Biology Authors: Sujin Lee Tae Jin Kim Source Type: research
SMAD7 expression in CAR-T cells improves persistence and safety for solid tumors
Cell Mol Immunol. 2024 Jan 4. doi: 10.1038/s41423-023-01120-y. Online ahead of print.ABSTRACTDespite the tremendous progress of chimeric antigen receptor T (CAR-T) cell therapy in hematological malignancies, their application in solid tumors has been limited largely due to T-cell exhaustion in the tumor microenvironment (TME) and systemic toxicity caused by excessive cytokine release. As a key regulator of the immunosuppressive TME, TGF-β promotes cytokine synthesis via the NF-κB pathway. Here, we coexpressed SMAD7, a suppressor of TGF-β signaling, with a HER2-targeted CAR in engineered T cells. These novel CAR-T cells ...
Source: Cellular and Molecular Immunology - January 4, 2024 Category: Molecular Biology Authors: Sixin Liang Rui Zheng Baile Zuo Jia Li Yiyi Wang Yujie Han Hao Dong Xiaojuan Zhao Yiting Zhang Pengju Wang Ruotong Meng Lintao Jia Angang Yang Bo Yan Source Type: research
In search of a pan-coronavirus vaccine: next-generation vaccine design and immune mechanisms
Cell Mol Immunol. 2023 Dec 26. doi: 10.1038/s41423-023-01116-8. Online ahead of print.ABSTRACTMembers of the coronaviridae family are endemic to human populations and have caused several epidemics and pandemics in recent history. In this review, we will discuss the feasibility of and progress toward the ultimate goal of creating a pan-coronavirus vaccine that can protect against infection and disease by all members of the coronavirus family. We will detail the unmet clinical need associated with the continued transmission of SARS-CoV-2, MERS-CoV and the four seasonal coronaviruses (HCoV-OC43, NL63, HKU1 and 229E) in humans...
Source: Cellular and Molecular Immunology - December 26, 2023 Category: Molecular Biology Authors: S Cankat M U Demael L Swadling Source Type: research
In search of a pan-coronavirus vaccine: next-generation vaccine design and immune mechanisms
Cell Mol Immunol. 2023 Dec 26. doi: 10.1038/s41423-023-01116-8. Online ahead of print.ABSTRACTMembers of the coronaviridae family are endemic to human populations and have caused several epidemics and pandemics in recent history. In this review, we will discuss the feasibility of and progress toward the ultimate goal of creating a pan-coronavirus vaccine that can protect against infection and disease by all members of the coronavirus family. We will detail the unmet clinical need associated with the continued transmission of SARS-CoV-2, MERS-CoV and the four seasonal coronaviruses (HCoV-OC43, NL63, HKU1 and 229E) in humans...
Source: Cellular and Molecular Immunology - December 26, 2023 Category: Molecular Biology Authors: S Cankat M U Demael L Swadling Source Type: research
In search of a pan-coronavirus vaccine: next-generation vaccine design and immune mechanisms
Cell Mol Immunol. 2023 Dec 26. doi: 10.1038/s41423-023-01116-8. Online ahead of print.ABSTRACTMembers of the coronaviridae family are endemic to human populations and have caused several epidemics and pandemics in recent history. In this review, we will discuss the feasibility of and progress toward the ultimate goal of creating a pan-coronavirus vaccine that can protect against infection and disease by all members of the coronavirus family. We will detail the unmet clinical need associated with the continued transmission of SARS-CoV-2, MERS-CoV and the four seasonal coronaviruses (HCoV-OC43, NL63, HKU1 and 229E) in humans...
Source: Cellular and Molecular Immunology - December 26, 2023 Category: Molecular Biology Authors: S Cankat M U Demael L Swadling Source Type: research
In search of a pan-coronavirus vaccine: next-generation vaccine design and immune mechanisms
Cell Mol Immunol. 2023 Dec 26. doi: 10.1038/s41423-023-01116-8. Online ahead of print.ABSTRACTMembers of the coronaviridae family are endemic to human populations and have caused several epidemics and pandemics in recent history. In this review, we will discuss the feasibility of and progress toward the ultimate goal of creating a pan-coronavirus vaccine that can protect against infection and disease by all members of the coronavirus family. We will detail the unmet clinical need associated with the continued transmission of SARS-CoV-2, MERS-CoV and the four seasonal coronaviruses (HCoV-OC43, NL63, HKU1 and 229E) in humans...
Source: Cellular and Molecular Immunology - December 26, 2023 Category: Molecular Biology Authors: S Cankat M U Demael L Swadling Source Type: research
