Insm1 regulates mTEC development and immune tolerance
Cell Mol Immunol. 2023 Nov 21. doi: 10.1038/s41423-023-01102-0. Online ahead of print.ABSTRACTThe expression of self-antigens in medullary thymic epithelial cells (mTECs) is essential for the establishment of immune tolerance, but the regulatory network that controls the generation and maintenance of the multitude of cell populations expressing self-antigens is poorly understood. Here, we show that Insm1, a zinc finger protein with known functions in neuroendocrine and neuronal cells, is broadly coexpressed with an autoimmune regulator (Aire) in mTECs. Insm1 expression is undetectable in most mimetic cell populations deriv...
Source: Cellular and Molecular Immunology - November 22, 2023 Category: Molecular Biology Authors: Weihua Tao Zhihuan Ye Yiqiu Wei Jianxue Wang Weixin Yang Guoxing Yu Jieyi Xiong Shiqi Jia Source Type: research
Interleukin-10 multitasking in allergic airway inflammation
Cell Mol Immunol. 2023 Nov 22. doi: 10.1038/s41423-023-01101-1. Online ahead of print.NO ABSTRACTPMID:37990033 | DOI:10.1038/s41423-023-01101-1 (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - November 22, 2023 Category: Molecular Biology Authors: Rudi W Hendriks Source Type: research
A tumor-associated heparan sulfate-related glycosaminoglycan promotes the generation of functional regulatory T cells
Cell Mol Immunol. 2023 Nov 22. doi: 10.1038/s41423-023-01096-9. Online ahead of print.ABSTRACTFunctional Tregs play a key role in tumor development and progression, representing a major barrier to anticancer immunity. The mechanisms by which Tregs are generated in cancer and the influence of the tumor microenvironment on these processes remain incompletely understood. Herein, by using NMR, chemoenzymatic structural assays and a plethora of in vitro and in vivo functional analyses, we demonstrate that the tumoral carbohydrate A10 (Ca10), a cell-surface carbohydrate derived from Ehrlich's tumor (ET) cells, is a heparan sulfa...
Source: Cellular and Molecular Immunology - November 22, 2023 Category: Molecular Biology Authors: Leticia Mart ín-Cruz Marcos Vi ñuela Ioanna Kalograiaki Alba Angelina Paola Oquist-Phillips Irene Real-Ar évalo Francisco Javier Ca ñada Jos é Ignacio Tudela Luis Molt ó Jes ús Moreno-Sierra Jos é Luis Subiza Oscar Palomares Source Type: research
Enhanced CD19 activity in B cells contributes to immunodeficiency in mice deficient in the ICF syndrome gene Zbtb24
Cell Mol Immunol. 2023 Nov 22. doi: 10.1038/s41423-023-01106-w. Online ahead of print.ABSTRACTImmunodeficiency, centromeric instability, and facial anomalies (ICF) syndrome is a rare autosomal recessive disorder characterized by DNA hypomethylation and antibody deficiency. It is caused by mutations in DNMT3B, ZBTB24, CDCA7, or HELLS. While progress has been made in elucidating the roles of these genes in regulating DNA methylation, little is known about the pathogenesis of the life-threatening hypogammaglobulinemia phenotype. Here, we show that mice deficient in Zbtb24 in the hematopoietic lineage recapitulate the major cl...
Source: Cellular and Molecular Immunology - November 22, 2023 Category: Molecular Biology Authors: Zhengzhou Ying Swanand Hardikar Joshua B Plummer Tewfik Hamidi Bin Liu Yueping Chen Jianjun Shen Yunxiang Mu Kevin M McBride Taiping Chen Source Type: research
Insm1 regulates mTEC development and immune tolerance
Cell Mol Immunol. 2023 Nov 21. doi: 10.1038/s41423-023-01102-0. Online ahead of print.ABSTRACTThe expression of self-antigens in medullary thymic epithelial cells (mTECs) is essential for the establishment of immune tolerance, but the regulatory network that controls the generation and maintenance of the multitude of cell populations expressing self-antigens is poorly understood. Here, we show that Insm1, a zinc finger protein with known functions in neuroendocrine and neuronal cells, is broadly coexpressed with an autoimmune regulator (Aire) in mTECs. Insm1 expression is undetectable in most mimetic cell populations deriv...
Source: Cellular and Molecular Immunology - November 22, 2023 Category: Molecular Biology Authors: Weihua Tao Zhihuan Ye Yiqiu Wei Jianxue Wang Weixin Yang Guoxing Yu Jieyi Xiong Shiqi Jia Source Type: research
Interleukin-10 multitasking in allergic airway inflammation
Cell Mol Immunol. 2023 Nov 22. doi: 10.1038/s41423-023-01101-1. Online ahead of print.NO ABSTRACTPMID:37990033 | DOI:10.1038/s41423-023-01101-1 (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - November 22, 2023 Category: Molecular Biology Authors: Rudi W Hendriks Source Type: research
A tumor-associated heparan sulfate-related glycosaminoglycan promotes the generation of functional regulatory T cells
Cell Mol Immunol. 2023 Nov 22. doi: 10.1038/s41423-023-01096-9. Online ahead of print.ABSTRACTFunctional Tregs play a key role in tumor development and progression, representing a major barrier to anticancer immunity. The mechanisms by which Tregs are generated in cancer and the influence of the tumor microenvironment on these processes remain incompletely understood. Herein, by using NMR, chemoenzymatic structural assays and a plethora of in vitro and in vivo functional analyses, we demonstrate that the tumoral carbohydrate A10 (Ca10), a cell-surface carbohydrate derived from Ehrlich's tumor (ET) cells, is a heparan sulfa...
Source: Cellular and Molecular Immunology - November 22, 2023 Category: Molecular Biology Authors: Leticia Mart ín-Cruz Marcos Vi ñuela Ioanna Kalograiaki Alba Angelina Paola Oquist-Phillips Irene Real-Ar évalo Francisco Javier Ca ñada Jos é Ignacio Tudela Luis Molt ó Jes ús Moreno-Sierra Jos é Luis Subiza Oscar Palomares Source Type: research
Enhanced CD19 activity in B cells contributes to immunodeficiency in mice deficient in the ICF syndrome gene Zbtb24
Cell Mol Immunol. 2023 Nov 22. doi: 10.1038/s41423-023-01106-w. Online ahead of print.ABSTRACTImmunodeficiency, centromeric instability, and facial anomalies (ICF) syndrome is a rare autosomal recessive disorder characterized by DNA hypomethylation and antibody deficiency. It is caused by mutations in DNMT3B, ZBTB24, CDCA7, or HELLS. While progress has been made in elucidating the roles of these genes in regulating DNA methylation, little is known about the pathogenesis of the life-threatening hypogammaglobulinemia phenotype. Here, we show that mice deficient in Zbtb24 in the hematopoietic lineage recapitulate the major cl...
Source: Cellular and Molecular Immunology - November 22, 2023 Category: Molecular Biology Authors: Zhengzhou Ying Swanand Hardikar Joshua B Plummer Tewfik Hamidi Bin Liu Yueping Chen Jianjun Shen Yunxiang Mu Kevin M McBride Taiping Chen Source Type: research
Insm1 regulates mTEC development and immune tolerance
Cell Mol Immunol. 2023 Nov 21. doi: 10.1038/s41423-023-01102-0. Online ahead of print.ABSTRACTThe expression of self-antigens in medullary thymic epithelial cells (mTECs) is essential for the establishment of immune tolerance, but the regulatory network that controls the generation and maintenance of the multitude of cell populations expressing self-antigens is poorly understood. Here, we show that Insm1, a zinc finger protein with known functions in neuroendocrine and neuronal cells, is broadly coexpressed with an autoimmune regulator (Aire) in mTECs. Insm1 expression is undetectable in most mimetic cell populations deriv...
Source: Cellular and Molecular Immunology - November 22, 2023 Category: Molecular Biology Authors: Weihua Tao Zhihuan Ye Yiqiu Wei Jianxue Wang Weixin Yang Guoxing Yu Jieyi Xiong Shiqi Jia Source Type: research
Interleukin-10 multitasking in allergic airway inflammation
Cell Mol Immunol. 2023 Nov 22. doi: 10.1038/s41423-023-01101-1. Online ahead of print.NO ABSTRACTPMID:37990033 | DOI:10.1038/s41423-023-01101-1 (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - November 22, 2023 Category: Molecular Biology Authors: Rudi W Hendriks Source Type: research
A tumor-associated heparan sulfate-related glycosaminoglycan promotes the generation of functional regulatory T cells
Cell Mol Immunol. 2023 Nov 22. doi: 10.1038/s41423-023-01096-9. Online ahead of print.ABSTRACTFunctional Tregs play a key role in tumor development and progression, representing a major barrier to anticancer immunity. The mechanisms by which Tregs are generated in cancer and the influence of the tumor microenvironment on these processes remain incompletely understood. Herein, by using NMR, chemoenzymatic structural assays and a plethora of in vitro and in vivo functional analyses, we demonstrate that the tumoral carbohydrate A10 (Ca10), a cell-surface carbohydrate derived from Ehrlich's tumor (ET) cells, is a heparan sulfa...
Source: Cellular and Molecular Immunology - November 22, 2023 Category: Molecular Biology Authors: Leticia Mart ín-Cruz Marcos Vi ñuela Ioanna Kalograiaki Alba Angelina Paola Oquist-Phillips Irene Real-Ar évalo Francisco Javier Ca ñada Jos é Ignacio Tudela Luis Molt ó Jes ús Moreno-Sierra Jos é Luis Subiza Oscar Palomares Source Type: research
Enhanced CD19 activity in B cells contributes to immunodeficiency in mice deficient in the ICF syndrome gene Zbtb24
Cell Mol Immunol. 2023 Nov 22. doi: 10.1038/s41423-023-01106-w. Online ahead of print.ABSTRACTImmunodeficiency, centromeric instability, and facial anomalies (ICF) syndrome is a rare autosomal recessive disorder characterized by DNA hypomethylation and antibody deficiency. It is caused by mutations in DNMT3B, ZBTB24, CDCA7, or HELLS. While progress has been made in elucidating the roles of these genes in regulating DNA methylation, little is known about the pathogenesis of the life-threatening hypogammaglobulinemia phenotype. Here, we show that mice deficient in Zbtb24 in the hematopoietic lineage recapitulate the major cl...
Source: Cellular and Molecular Immunology - November 22, 2023 Category: Molecular Biology Authors: Zhengzhou Ying Swanand Hardikar Joshua B Plummer Tewfik Hamidi Bin Liu Yueping Chen Jianjun Shen Yunxiang Mu Kevin M McBride Taiping Chen Source Type: research
Insm1 regulates mTEC development and immune tolerance
Cell Mol Immunol. 2023 Nov 21. doi: 10.1038/s41423-023-01102-0. Online ahead of print.ABSTRACTThe expression of self-antigens in medullary thymic epithelial cells (mTECs) is essential for the establishment of immune tolerance, but the regulatory network that controls the generation and maintenance of the multitude of cell populations expressing self-antigens is poorly understood. Here, we show that Insm1, a zinc finger protein with known functions in neuroendocrine and neuronal cells, is broadly coexpressed with an autoimmune regulator (Aire) in mTECs. Insm1 expression is undetectable in most mimetic cell populations deriv...
Source: Cellular and Molecular Immunology - November 22, 2023 Category: Molecular Biology Authors: Weihua Tao Zhihuan Ye Yiqiu Wei Jianxue Wang Weixin Yang Guoxing Yu Jieyi Xiong Shiqi Jia Source Type: research
Interleukin-10 multitasking in allergic airway inflammation
Cell Mol Immunol. 2023 Nov 22. doi: 10.1038/s41423-023-01101-1. Online ahead of print.NO ABSTRACTPMID:37990033 | DOI:10.1038/s41423-023-01101-1 (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - November 22, 2023 Category: Molecular Biology Authors: Rudi W Hendriks Source Type: research
A tumor-associated heparan sulfate-related glycosaminoglycan promotes the generation of functional regulatory T cells
Cell Mol Immunol. 2023 Nov 22. doi: 10.1038/s41423-023-01096-9. Online ahead of print.ABSTRACTFunctional Tregs play a key role in tumor development and progression, representing a major barrier to anticancer immunity. The mechanisms by which Tregs are generated in cancer and the influence of the tumor microenvironment on these processes remain incompletely understood. Herein, by using NMR, chemoenzymatic structural assays and a plethora of in vitro and in vivo functional analyses, we demonstrate that the tumoral carbohydrate A10 (Ca10), a cell-surface carbohydrate derived from Ehrlich's tumor (ET) cells, is a heparan sulfa...
Source: Cellular and Molecular Immunology - November 22, 2023 Category: Molecular Biology Authors: Leticia Mart ín-Cruz Marcos Vi ñuela Ioanna Kalograiaki Alba Angelina Paola Oquist-Phillips Irene Real-Ar évalo Francisco Javier Ca ñada Jos é Ignacio Tudela Luis Molt ó Jes ús Moreno-Sierra Jos é Luis Subiza Oscar Palomares Source Type: research
