Insm1: orchestrating cellular mimicry in the thymus medulla
Cell Mol Immunol. 2024 Mar 19. doi: 10.1038/s41423-024-01151-z. Online ahead of print.NO ABSTRACTPMID:38503886 | DOI:10.1038/s41423-024-01151-z (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - March 20, 2024 Category: Molecular Biology Authors: K D James J E Cowan Source Type: research
Neutrophil ALDH2 is a new therapeutic target for the effective treatment of sepsis-induced ARDS
Cell Mol Immunol. 2024 Mar 12. doi: 10.1038/s41423-024-01146-w. Online ahead of print.ABSTRACTAcetaldehyde dehydrogenase 2 (ALDH2) mutations are commonly found in a subgroup of the Asian population. However, the role of ALDH2 in septic acute respiratory distress syndrome (ARDS) remains unknown. Here, we showed that human subjects carrying the ALDH2rs671 mutation were highly susceptible to developing septic ARDS. Intriguingly, ALDH2rs671-ARDS patients showed higher levels of blood cell-free DNA (cfDNA) and myeloperoxidase (MPO)-DNA than ALDH2WT-ARDS patients. To investigate the mechanisms underlying ALDH2 deficiency in the ...
Source: Cellular and Molecular Immunology - March 13, 2024 Category: Molecular Biology Authors: Changchang Xu Lin Zhang Shaoyu Xu Zichen Wang Qi Han Ying Lv Xingfang Wang Xiangxin Zhang Qingju Zhang Ying Zhang Simeng He Qiuhuan Yuan Yuan Bian Chuanbao Li Jiali Wang Feng Xu Yihai Cao Jiaojiao Pang Yuguo Chen Source Type: research
Neutrophil ALDH2 is a new therapeutic target for the effective treatment of sepsis-induced ARDS
Cell Mol Immunol. 2024 Mar 12. doi: 10.1038/s41423-024-01146-w. Online ahead of print.ABSTRACTAcetaldehyde dehydrogenase 2 (ALDH2) mutations are commonly found in a subgroup of the Asian population. However, the role of ALDH2 in septic acute respiratory distress syndrome (ARDS) remains unknown. Here, we showed that human subjects carrying the ALDH2rs671 mutation were highly susceptible to developing septic ARDS. Intriguingly, ALDH2rs671-ARDS patients showed higher levels of blood cell-free DNA (cfDNA) and myeloperoxidase (MPO)-DNA than ALDH2WT-ARDS patients. To investigate the mechanisms underlying ALDH2 deficiency in the ...
Source: Cellular and Molecular Immunology - March 13, 2024 Category: Molecular Biology Authors: Changchang Xu Lin Zhang Shaoyu Xu Zichen Wang Qi Han Ying Lv Xingfang Wang Xiangxin Zhang Qingju Zhang Ying Zhang Simeng He Qiuhuan Yuan Yuan Bian Chuanbao Li Jiali Wang Feng Xu Yihai Cao Jiaojiao Pang Yuguo Chen Source Type: research
Neutrophil ALDH2 is a new therapeutic target for the effective treatment of sepsis-induced ARDS
Cell Mol Immunol. 2024 Mar 12. doi: 10.1038/s41423-024-01146-w. Online ahead of print.ABSTRACTAcetaldehyde dehydrogenase 2 (ALDH2) mutations are commonly found in a subgroup of the Asian population. However, the role of ALDH2 in septic acute respiratory distress syndrome (ARDS) remains unknown. Here, we showed that human subjects carrying the ALDH2rs671 mutation were highly susceptible to developing septic ARDS. Intriguingly, ALDH2rs671-ARDS patients showed higher levels of blood cell-free DNA (cfDNA) and myeloperoxidase (MPO)-DNA than ALDH2WT-ARDS patients. To investigate the mechanisms underlying ALDH2 deficiency in the ...
Source: Cellular and Molecular Immunology - March 13, 2024 Category: Molecular Biology Authors: Changchang Xu Lin Zhang Shaoyu Xu Zichen Wang Qi Han Ying Lv Xingfang Wang Xiangxin Zhang Qingju Zhang Ying Zhang Simeng He Qiuhuan Yuan Yuan Bian Chuanbao Li Jiali Wang Feng Xu Yihai Cao Jiaojiao Pang Yuguo Chen Source Type: research
Neutrophil ALDH2 is a new therapeutic target for the effective treatment of sepsis-induced ARDS
Cell Mol Immunol. 2024 Mar 12. doi: 10.1038/s41423-024-01146-w. Online ahead of print.ABSTRACTAcetaldehyde dehydrogenase 2 (ALDH2) mutations are commonly found in a subgroup of the Asian population. However, the role of ALDH2 in septic acute respiratory distress syndrome (ARDS) remains unknown. Here, we showed that human subjects carrying the ALDH2rs671 mutation were highly susceptible to developing septic ARDS. Intriguingly, ALDH2rs671-ARDS patients showed higher levels of blood cell-free DNA (cfDNA) and myeloperoxidase (MPO)-DNA than ALDH2WT-ARDS patients. To investigate the mechanisms underlying ALDH2 deficiency in the ...
Source: Cellular and Molecular Immunology - March 13, 2024 Category: Molecular Biology Authors: Changchang Xu Lin Zhang Shaoyu Xu Zichen Wang Qi Han Ying Lv Xingfang Wang Xiangxin Zhang Qingju Zhang Ying Zhang Simeng He Qiuhuan Yuan Yuan Bian Chuanbao Li Jiali Wang Feng Xu Yihai Cao Jiaojiao Pang Yuguo Chen Source Type: research
Neutrophil ALDH2 is a new therapeutic target for the effective treatment of sepsis-induced ARDS
Cell Mol Immunol. 2024 Mar 12. doi: 10.1038/s41423-024-01146-w. Online ahead of print.ABSTRACTAcetaldehyde dehydrogenase 2 (ALDH2) mutations are commonly found in a subgroup of the Asian population. However, the role of ALDH2 in septic acute respiratory distress syndrome (ARDS) remains unknown. Here, we showed that human subjects carrying the ALDH2rs671 mutation were highly susceptible to developing septic ARDS. Intriguingly, ALDH2rs671-ARDS patients showed higher levels of blood cell-free DNA (cfDNA) and myeloperoxidase (MPO)-DNA than ALDH2WT-ARDS patients. To investigate the mechanisms underlying ALDH2 deficiency in the ...
Source: Cellular and Molecular Immunology - March 13, 2024 Category: Molecular Biology Authors: Changchang Xu Lin Zhang Shaoyu Xu Zichen Wang Qi Han Ying Lv Xingfang Wang Xiangxin Zhang Qingju Zhang Ying Zhang Simeng He Qiuhuan Yuan Yuan Bian Chuanbao Li Jiali Wang Feng Xu Yihai Cao Jiaojiao Pang Yuguo Chen Source Type: research
Neutrophil ALDH2 is a new therapeutic target for the effective treatment of sepsis-induced ARDS
Cell Mol Immunol. 2024 Mar 12. doi: 10.1038/s41423-024-01146-w. Online ahead of print.ABSTRACTAcetaldehyde dehydrogenase 2 (ALDH2) mutations are commonly found in a subgroup of the Asian population. However, the role of ALDH2 in septic acute respiratory distress syndrome (ARDS) remains unknown. Here, we showed that human subjects carrying the ALDH2rs671 mutation were highly susceptible to developing septic ARDS. Intriguingly, ALDH2rs671-ARDS patients showed higher levels of blood cell-free DNA (cfDNA) and myeloperoxidase (MPO)-DNA than ALDH2WT-ARDS patients. To investigate the mechanisms underlying ALDH2 deficiency in the ...
Source: Cellular and Molecular Immunology - March 13, 2024 Category: Molecular Biology Authors: Changchang Xu Lin Zhang Shaoyu Xu Zichen Wang Qi Han Ying Lv Xingfang Wang Xiangxin Zhang Qingju Zhang Ying Zhang Simeng He Qiuhuan Yuan Yuan Bian Chuanbao Li Jiali Wang Feng Xu Yihai Cao Jiaojiao Pang Yuguo Chen Source Type: research
Neutrophils in the tumor microenvironment - when a company becomes a crowd
Cell Mol Immunol. 2024 Mar 8. doi: 10.1038/s41423-024-01147-9. Online ahead of print.NO ABSTRACTPMID:38459242 | DOI:10.1038/s41423-024-01147-9 (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - March 8, 2024 Category: Molecular Biology Authors: Zvi G Fridlender Zvi Granot Source Type: research
Mucosal T-cell responses to chronic viral infections: Implications for vaccine design
Cell Mol Immunol. 2024 Mar 8. doi: 10.1038/s41423-024-01140-2. Online ahead of print.ABSTRACTMucosal surfaces that line the respiratory, gastrointestinal and genitourinary tracts are the major interfaces between the immune system and the environment. Their unique immunological landscape is characterized by the necessity of balancing tolerance to commensal microorganisms and other innocuous exposures against protection from pathogenic threats such as viruses. Numerous pathogenic viruses, including herpesviruses and retroviruses, exploit this environment to establish chronic infection. Effector and regulatory T-cell populati...
Source: Cellular and Molecular Immunology - March 8, 2024 Category: Molecular Biology Authors: Mohammed Al-Talib Sandra Dimonte Ian R Humphreys Source Type: research
Neutrophils in the tumor microenvironment - when a company becomes a crowd
Cell Mol Immunol. 2024 Mar 8. doi: 10.1038/s41423-024-01147-9. Online ahead of print.NO ABSTRACTPMID:38459242 | DOI:10.1038/s41423-024-01147-9 (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - March 8, 2024 Category: Molecular Biology Authors: Zvi G Fridlender Zvi Granot Source Type: research
Mucosal T-cell responses to chronic viral infections: Implications for vaccine design
Cell Mol Immunol. 2024 Mar 8. doi: 10.1038/s41423-024-01140-2. Online ahead of print.ABSTRACTMucosal surfaces that line the respiratory, gastrointestinal and genitourinary tracts are the major interfaces between the immune system and the environment. Their unique immunological landscape is characterized by the necessity of balancing tolerance to commensal microorganisms and other innocuous exposures against protection from pathogenic threats such as viruses. Numerous pathogenic viruses, including herpesviruses and retroviruses, exploit this environment to establish chronic infection. Effector and regulatory T-cell populati...
Source: Cellular and Molecular Immunology - March 8, 2024 Category: Molecular Biology Authors: Mohammed Al-Talib Sandra Dimonte Ian R Humphreys Source Type: research
Neutrophils in the tumor microenvironment - when a company becomes a crowd
Cell Mol Immunol. 2024 Mar 8. doi: 10.1038/s41423-024-01147-9. Online ahead of print.NO ABSTRACTPMID:38459242 | DOI:10.1038/s41423-024-01147-9 (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - March 8, 2024 Category: Molecular Biology Authors: Zvi G Fridlender Zvi Granot Source Type: research
Mucosal T-cell responses to chronic viral infections: Implications for vaccine design
Cell Mol Immunol. 2024 Mar 8. doi: 10.1038/s41423-024-01140-2. Online ahead of print.ABSTRACTMucosal surfaces that line the respiratory, gastrointestinal and genitourinary tracts are the major interfaces between the immune system and the environment. Their unique immunological landscape is characterized by the necessity of balancing tolerance to commensal microorganisms and other innocuous exposures against protection from pathogenic threats such as viruses. Numerous pathogenic viruses, including herpesviruses and retroviruses, exploit this environment to establish chronic infection. Effector and regulatory T-cell populati...
Source: Cellular and Molecular Immunology - March 8, 2024 Category: Molecular Biology Authors: Mohammed Al-Talib Sandra Dimonte Ian R Humphreys Source Type: research
Neutrophils in the tumor microenvironment - when a company becomes a crowd
Cell Mol Immunol. 2024 Mar 8. doi: 10.1038/s41423-024-01147-9. Online ahead of print.NO ABSTRACTPMID:38459242 | DOI:10.1038/s41423-024-01147-9 (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - March 8, 2024 Category: Molecular Biology Authors: Zvi G Fridlender Zvi Granot Source Type: research
Mucosal T-cell responses to chronic viral infections: Implications for vaccine design
Cell Mol Immunol. 2024 Mar 8. doi: 10.1038/s41423-024-01140-2. Online ahead of print.ABSTRACTMucosal surfaces that line the respiratory, gastrointestinal and genitourinary tracts are the major interfaces between the immune system and the environment. Their unique immunological landscape is characterized by the necessity of balancing tolerance to commensal microorganisms and other innocuous exposures against protection from pathogenic threats such as viruses. Numerous pathogenic viruses, including herpesviruses and retroviruses, exploit this environment to establish chronic infection. Effector and regulatory T-cell populati...
Source: Cellular and Molecular Immunology - March 8, 2024 Category: Molecular Biology Authors: Mohammed Al-Talib Sandra Dimonte Ian R Humphreys Source Type: research
