MST4 kinase regulates immune thrombocytopenia by phosphorylating STAT1-mediated M1 polarization of macrophages
Cell Mol Immunol. 2023 Oct 13. doi: 10.1038/s41423-023-01089-8. Online ahead of print.ABSTRACTPrimary immune thrombocytopenia (ITP) is an autoimmune hemorrhagic disorder in which macrophages play a critical role. Mammalian sterile-20-like kinase 4 (MST4), a member of the germinal-center kinase STE20 family, has been demonstrated to be a regulator of inflammation. Whether MST4 participates in the macrophage-dependent inflammation of ITP remains elusive. The expression and function of MST4 in macrophages of ITP patients and THP-1 cells, and of a macrophage-specific Mst4-/- (Mst4ΔM/ΔM) ITP mouse model were determined. Macro...
Source: Cellular and Molecular Immunology - October 13, 2023 Category: Molecular Biology Authors: Jingjing Cao Lili Ji Yanxia Zhan Xia Shao Pengcheng Xu Boting Wu Pu Chen Luya Cheng Xibing Zhuang Yang Ou Fanli Hua Lihua Sun Feng Li Hao Chen Zhaocai Zhou Yunfeng Cheng Source Type: research

MST4 kinase regulates immune thrombocytopenia by phosphorylating STAT1-mediated M1 polarization of macrophages
Cell Mol Immunol. 2023 Oct 13. doi: 10.1038/s41423-023-01089-8. Online ahead of print.ABSTRACTPrimary immune thrombocytopenia (ITP) is an autoimmune hemorrhagic disorder in which macrophages play a critical role. Mammalian sterile-20-like kinase 4 (MST4), a member of the germinal-center kinase STE20 family, has been demonstrated to be a regulator of inflammation. Whether MST4 participates in the macrophage-dependent inflammation of ITP remains elusive. The expression and function of MST4 in macrophages of ITP patients and THP-1 cells, and of a macrophage-specific Mst4-/- (Mst4ΔM/ΔM) ITP mouse model were determined. Macro...
Source: Cellular and Molecular Immunology - October 13, 2023 Category: Molecular Biology Authors: Jingjing Cao Lili Ji Yanxia Zhan Xia Shao Pengcheng Xu Boting Wu Pu Chen Luya Cheng Xibing Zhuang Yang Ou Fanli Hua Lihua Sun Feng Li Hao Chen Zhaocai Zhou Yunfeng Cheng Source Type: research

MST4 kinase regulates immune thrombocytopenia by phosphorylating STAT1-mediated M1 polarization of macrophages
Cell Mol Immunol. 2023 Oct 13. doi: 10.1038/s41423-023-01089-8. Online ahead of print.ABSTRACTPrimary immune thrombocytopenia (ITP) is an autoimmune hemorrhagic disorder in which macrophages play a critical role. Mammalian sterile-20-like kinase 4 (MST4), a member of the germinal-center kinase STE20 family, has been demonstrated to be a regulator of inflammation. Whether MST4 participates in the macrophage-dependent inflammation of ITP remains elusive. The expression and function of MST4 in macrophages of ITP patients and THP-1 cells, and of a macrophage-specific Mst4-/- (Mst4ΔM/ΔM) ITP mouse model were determined. Macro...
Source: Cellular and Molecular Immunology - October 13, 2023 Category: Molecular Biology Authors: Jingjing Cao Lili Ji Yanxia Zhan Xia Shao Pengcheng Xu Boting Wu Pu Chen Luya Cheng Xibing Zhuang Yang Ou Fanli Hua Lihua Sun Feng Li Hao Chen Zhaocai Zhou Yunfeng Cheng Source Type: research

MST4 kinase regulates immune thrombocytopenia by phosphorylating STAT1-mediated M1 polarization of macrophages
Cell Mol Immunol. 2023 Oct 13. doi: 10.1038/s41423-023-01089-8. Online ahead of print.ABSTRACTPrimary immune thrombocytopenia (ITP) is an autoimmune hemorrhagic disorder in which macrophages play a critical role. Mammalian sterile-20-like kinase 4 (MST4), a member of the germinal-center kinase STE20 family, has been demonstrated to be a regulator of inflammation. Whether MST4 participates in the macrophage-dependent inflammation of ITP remains elusive. The expression and function of MST4 in macrophages of ITP patients and THP-1 cells, and of a macrophage-specific Mst4-/- (Mst4ΔM/ΔM) ITP mouse model were determined. Macro...
Source: Cellular and Molecular Immunology - October 13, 2023 Category: Molecular Biology Authors: Jingjing Cao Lili Ji Yanxia Zhan Xia Shao Pengcheng Xu Boting Wu Pu Chen Luya Cheng Xibing Zhuang Yang Ou Fanli Hua Lihua Sun Feng Li Hao Chen Zhaocai Zhou Yunfeng Cheng Source Type: research

MST4 kinase regulates immune thrombocytopenia by phosphorylating STAT1-mediated M1 polarization of macrophages
Cell Mol Immunol. 2023 Oct 13. doi: 10.1038/s41423-023-01089-8. Online ahead of print.ABSTRACTPrimary immune thrombocytopenia (ITP) is an autoimmune hemorrhagic disorder in which macrophages play a critical role. Mammalian sterile-20-like kinase 4 (MST4), a member of the germinal-center kinase STE20 family, has been demonstrated to be a regulator of inflammation. Whether MST4 participates in the macrophage-dependent inflammation of ITP remains elusive. The expression and function of MST4 in macrophages of ITP patients and THP-1 cells, and of a macrophage-specific Mst4-/- (Mst4ΔM/ΔM) ITP mouse model were determined. Macro...
Source: Cellular and Molecular Immunology - October 13, 2023 Category: Molecular Biology Authors: Jingjing Cao Lili Ji Yanxia Zhan Xia Shao Pengcheng Xu Boting Wu Pu Chen Luya Cheng Xibing Zhuang Yang Ou Fanli Hua Lihua Sun Feng Li Hao Chen Zhaocai Zhou Yunfeng Cheng Source Type: research

MST4 kinase regulates immune thrombocytopenia by phosphorylating STAT1-mediated M1 polarization of macrophages
Cell Mol Immunol. 2023 Oct 13. doi: 10.1038/s41423-023-01089-8. Online ahead of print.ABSTRACTPrimary immune thrombocytopenia (ITP) is an autoimmune hemorrhagic disorder in which macrophages play a critical role. Mammalian sterile-20-like kinase 4 (MST4), a member of the germinal-center kinase STE20 family, has been demonstrated to be a regulator of inflammation. Whether MST4 participates in the macrophage-dependent inflammation of ITP remains elusive. The expression and function of MST4 in macrophages of ITP patients and THP-1 cells, and of a macrophage-specific Mst4-/- (Mst4ΔM/ΔM) ITP mouse model were determined. Macro...
Source: Cellular and Molecular Immunology - October 13, 2023 Category: Molecular Biology Authors: Jingjing Cao Lili Ji Yanxia Zhan Xia Shao Pengcheng Xu Boting Wu Pu Chen Luya Cheng Xibing Zhuang Yang Ou Fanli Hua Lihua Sun Feng Li Hao Chen Zhaocai Zhou Yunfeng Cheng Source Type: research

A de novo missense mutation in MPP2 confers an increased risk of Vogt-Koyanagi-Harada disease as shown by trio-based whole-exome sequencing
Cell Mol Immunol. 2023 Oct 12. doi: 10.1038/s41423-023-01088-9. Online ahead of print.ABSTRACTVogt-Koyanagi-Harada (VKH) disease is a leading cause of blindness in young and middle-aged people. However, the etiology of VKH disease remains unclear. Here, we performed the first trio-based whole-exome sequencing study, which enrolled 25 VKH patients and 50 controls, followed by a study of 2081 VKH patients from a Han Chinese population to uncover detrimental mutations. A total of 15 de novo mutations in VKH patients were identified, with one of the most important being the membrane palmitoylated protein 2 (MPP2) p.K315N (MPP2...
Source: Cellular and Molecular Immunology - October 12, 2023 Category: Molecular Biology Authors: Xianyang Liu Jiayu Meng Xingyun Liao Yusen Liu Qian Zhou Zongren Xu Shuming Yin Qingfeng Cao Guannan Su Siyuan He Wanqian Li Xiaotang Wang Guoqing Wang Dali Li Peizeng Yang Shengping Hou Source Type: research

A de novo missense mutation in MPP2 confers an increased risk of Vogt-Koyanagi-Harada disease as shown by trio-based whole-exome sequencing
Cell Mol Immunol. 2023 Oct 12. doi: 10.1038/s41423-023-01088-9. Online ahead of print.ABSTRACTVogt-Koyanagi-Harada (VKH) disease is a leading cause of blindness in young and middle-aged people. However, the etiology of VKH disease remains unclear. Here, we performed the first trio-based whole-exome sequencing study, which enrolled 25 VKH patients and 50 controls, followed by a study of 2081 VKH patients from a Han Chinese population to uncover detrimental mutations. A total of 15 de novo mutations in VKH patients were identified, with one of the most important being the membrane palmitoylated protein 2 (MPP2) p.K315N (MPP2...
Source: Cellular and Molecular Immunology - October 12, 2023 Category: Molecular Biology Authors: Xianyang Liu Jiayu Meng Xingyun Liao Yusen Liu Qian Zhou Zongren Xu Shuming Yin Qingfeng Cao Guannan Su Siyuan He Wanqian Li Xiaotang Wang Guoqing Wang Dali Li Peizeng Yang Shengping Hou Source Type: research

The immune response to SARS-CoV-2 in people with HIV
Cell Mol Immunol. 2023 Oct 11. doi: 10.1038/s41423-023-01087-w. Online ahead of print.ABSTRACTThis review examines the intersection of the HIV and SARS-CoV-2 pandemics. People with HIV (PWH) are a heterogeneous group that differ in their degree of immune suppression, immune reconstitution, and viral control. While COVID-19 in those with well-controlled HIV infection poses no greater risk than that for HIV-uninfected individuals, people with advanced HIV disease are more vulnerable to poor COVID-19 outcomes. COVID-19 vaccines are effective and well tolerated in the majority of PWH, though reduced vaccine efficacy, breakthro...
Source: Cellular and Molecular Immunology - October 11, 2023 Category: Molecular Biology Authors: Maxine A H öft Wendy A Burgers Catherine Riou Source Type: research

FBXO38 regulates macrophage polarization to control the development of cancer and colitis
Cell Mol Immunol. 2023 Oct 12. doi: 10.1038/s41423-023-01081-2. Online ahead of print.ABSTRACTMacrophages are highly plastic cells that differentially regulate multiple pathological conditions, including cancer and autoimmune diseases. In response to various stimuli, macrophages activate different intrinsic signaling pathways and polarize into distinct macrophage subsets. We aimed to identify key new effectors that could control macrophage polarization and impact the development of cancer or colitis. Following treatment with the supernatants of tumor cells, macrophages showed an upregulation in Fbxo38 expression. Subsequen...
Source: Cellular and Molecular Immunology - October 11, 2023 Category: Molecular Biology Authors: Xin Zheng Qi Jiang Mingshun Han Fenfen Ye Mingchang Wang Ying Qiu Jialu Wang Minxia Gao Fajian Hou Hongyan Wang Source Type: research

Author Correction: Regulation of CD8 < sup > + < /sup > T memory and exhaustion by the mTOR signals
Cell Mol Immunol. 2023 Oct 11. doi: 10.1038/s41423-023-01090-1. Online ahead of print.NO ABSTRACTPMID:37821622 | DOI:10.1038/s41423-023-01090-1 (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - October 11, 2023 Category: Molecular Biology Authors: Yao Chen Ziyang Xu Hongxiang Sun Xinxing Ouyang Yuheng Han Haihui Yu Ningbo Wu Yiting Xie Bing Su Source Type: research

The immune response to SARS-CoV-2 in people with HIV
Cell Mol Immunol. 2023 Oct 11. doi: 10.1038/s41423-023-01087-w. Online ahead of print.ABSTRACTThis review examines the intersection of the HIV and SARS-CoV-2 pandemics. People with HIV (PWH) are a heterogeneous group that differ in their degree of immune suppression, immune reconstitution, and viral control. While COVID-19 in those with well-controlled HIV infection poses no greater risk than that for HIV-uninfected individuals, people with advanced HIV disease are more vulnerable to poor COVID-19 outcomes. COVID-19 vaccines are effective and well tolerated in the majority of PWH, though reduced vaccine efficacy, breakthro...
Source: Cellular and Molecular Immunology - October 11, 2023 Category: Molecular Biology Authors: Maxine A H öft Wendy A Burgers Catherine Riou Source Type: research

FBXO38 regulates macrophage polarization to control the development of cancer and colitis
Cell Mol Immunol. 2023 Oct 12. doi: 10.1038/s41423-023-01081-2. Online ahead of print.ABSTRACTMacrophages are highly plastic cells that differentially regulate multiple pathological conditions, including cancer and autoimmune diseases. In response to various stimuli, macrophages activate different intrinsic signaling pathways and polarize into distinct macrophage subsets. We aimed to identify key new effectors that could control macrophage polarization and impact the development of cancer or colitis. Following treatment with the supernatants of tumor cells, macrophages showed an upregulation in Fbxo38 expression. Subsequen...
Source: Cellular and Molecular Immunology - October 11, 2023 Category: Molecular Biology Authors: Xin Zheng Qi Jiang Mingshun Han Fenfen Ye Mingchang Wang Ying Qiu Jialu Wang Minxia Gao Fajian Hou Hongyan Wang Source Type: research

Author Correction: Regulation of CD8 < sup > + < /sup > T memory and exhaustion by the mTOR signals
Cell Mol Immunol. 2023 Oct 11. doi: 10.1038/s41423-023-01090-1. Online ahead of print.NO ABSTRACTPMID:37821622 | DOI:10.1038/s41423-023-01090-1 (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - October 11, 2023 Category: Molecular Biology Authors: Yao Chen Ziyang Xu Hongxiang Sun Xinxing Ouyang Yuheng Han Haihui Yu Ningbo Wu Yiting Xie Bing Su Source Type: research

Thiostrepton alleviates experimental colitis by promoting ROR γt ubiquitination and modulating dysbiosis
This study aimed to elucidate the therapeutic effect of TST on experimental colitis and identify its targets. The effect of TST on colon inflammation was evaluated in a dextran sulfate sodium (DSS)-induced colitis model and a T-cell transfer colitis model. The therapeutic targets of TST were investigated by cytokine profiling, immunophenotyping and biochemical approaches. The effect of TST on the gut microbiota and its contribution to colitis were evaluated in mice with DSS-induced colitis that were subjected to gut microbiota depletion and fecal microbiota transplantation (FMT). Alterations in the gut microbiota caused by...
Source: Cellular and Molecular Immunology - September 26, 2023 Category: Molecular Biology Authors: Ya Luo Cheng Liu Yuan Luo Xianglian Zhang Jing Li Changjiang Hu Shiming Yang Source Type: research