Mucosal T-cell responses to chronic viral infections: Implications for vaccine design
Cell Mol Immunol. 2024 Mar 8. doi: 10.1038/s41423-024-01140-2. Online ahead of print.ABSTRACTMucosal surfaces that line the respiratory, gastrointestinal and genitourinary tracts are the major interfaces between the immune system and the environment. Their unique immunological landscape is characterized by the necessity of balancing tolerance to commensal microorganisms and other innocuous exposures against protection from pathogenic threats such as viruses. Numerous pathogenic viruses, including herpesviruses and retroviruses, exploit this environment to establish chronic infection. Effector and regulatory T-cell populati...
Source: Cellular and Molecular Immunology - March 8, 2024 Category: Molecular Biology Authors: Mohammed Al-Talib Sandra Dimonte Ian R Humphreys Source Type: research

Neutrophils in the tumor microenvironment - when a company becomes a crowd
Cell Mol Immunol. 2024 Mar 8. doi: 10.1038/s41423-024-01147-9. Online ahead of print.NO ABSTRACTPMID:38459242 | DOI:10.1038/s41423-024-01147-9 (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - March 8, 2024 Category: Molecular Biology Authors: Zvi G Fridlender Zvi Granot Source Type: research

Mucosal T-cell responses to chronic viral infections: Implications for vaccine design
Cell Mol Immunol. 2024 Mar 8. doi: 10.1038/s41423-024-01140-2. Online ahead of print.ABSTRACTMucosal surfaces that line the respiratory, gastrointestinal and genitourinary tracts are the major interfaces between the immune system and the environment. Their unique immunological landscape is characterized by the necessity of balancing tolerance to commensal microorganisms and other innocuous exposures against protection from pathogenic threats such as viruses. Numerous pathogenic viruses, including herpesviruses and retroviruses, exploit this environment to establish chronic infection. Effector and regulatory T-cell populati...
Source: Cellular and Molecular Immunology - March 8, 2024 Category: Molecular Biology Authors: Mohammed Al-Talib Sandra Dimonte Ian R Humphreys Source Type: research

Neutrophils in the tumor microenvironment - when a company becomes a crowd
Cell Mol Immunol. 2024 Mar 8. doi: 10.1038/s41423-024-01147-9. Online ahead of print.NO ABSTRACTPMID:38459242 | DOI:10.1038/s41423-024-01147-9 (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - March 8, 2024 Category: Molecular Biology Authors: Zvi G Fridlender Zvi Granot Source Type: research

Mucosal T-cell responses to chronic viral infections: Implications for vaccine design
Cell Mol Immunol. 2024 Mar 8. doi: 10.1038/s41423-024-01140-2. Online ahead of print.ABSTRACTMucosal surfaces that line the respiratory, gastrointestinal and genitourinary tracts are the major interfaces between the immune system and the environment. Their unique immunological landscape is characterized by the necessity of balancing tolerance to commensal microorganisms and other innocuous exposures against protection from pathogenic threats such as viruses. Numerous pathogenic viruses, including herpesviruses and retroviruses, exploit this environment to establish chronic infection. Effector and regulatory T-cell populati...
Source: Cellular and Molecular Immunology - March 8, 2024 Category: Molecular Biology Authors: Mohammed Al-Talib Sandra Dimonte Ian R Humphreys Source Type: research

Neutrophils in the tumor microenvironment - when a company becomes a crowd
Cell Mol Immunol. 2024 Mar 8. doi: 10.1038/s41423-024-01147-9. Online ahead of print.NO ABSTRACTPMID:38459242 | DOI:10.1038/s41423-024-01147-9 (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - March 8, 2024 Category: Molecular Biology Authors: Zvi G Fridlender Zvi Granot Source Type: research

Mucosal T-cell responses to chronic viral infections: Implications for vaccine design
Cell Mol Immunol. 2024 Mar 8. doi: 10.1038/s41423-024-01140-2. Online ahead of print.ABSTRACTMucosal surfaces that line the respiratory, gastrointestinal and genitourinary tracts are the major interfaces between the immune system and the environment. Their unique immunological landscape is characterized by the necessity of balancing tolerance to commensal microorganisms and other innocuous exposures against protection from pathogenic threats such as viruses. Numerous pathogenic viruses, including herpesviruses and retroviruses, exploit this environment to establish chronic infection. Effector and regulatory T-cell populati...
Source: Cellular and Molecular Immunology - March 8, 2024 Category: Molecular Biology Authors: Mohammed Al-Talib Sandra Dimonte Ian R Humphreys Source Type: research

Engagement of sialylated glycans with Siglec receptors on suppressive myeloid cells inhibits anticancer immunity via CCL2
Cell Mol Immunol. 2024 Mar 6. doi: 10.1038/s41423-024-01142-0. Online ahead of print.ABSTRACTThe overexpression of sialic acids on glycans, called hypersialylation, is a common alteration found in cancer cells. Sialylated glycans can enhance immune evasion by interacting with sialic acid-binding immunoglobulin-like lectin (Siglec) receptors on tumor-infiltrating immune cells. Here, we investigated the effect of sialylated glycans and their interaction with Siglec receptors on myeloid-derived suppressor cells (MDSCs). We found that MDSCs derived from the blood of lung cancer patients and tumor-bearing mice strongly express ...
Source: Cellular and Molecular Immunology - March 6, 2024 Category: Molecular Biology Authors: Ronja Wieboldt Michael Sandholzer Emanuele Carlini Chia-Wei Lin Anastasiya B örsch Andreas Zingg Didier Lardinois Petra Herzig Leyla Don Alfred Zippelius Heinz L äubli Natalia Rodrigues Mantuano Source Type: research

Engagement of sialylated glycans with Siglec receptors on suppressive myeloid cells inhibits anticancer immunity via CCL2
Cell Mol Immunol. 2024 Mar 6. doi: 10.1038/s41423-024-01142-0. Online ahead of print.ABSTRACTThe overexpression of sialic acids on glycans, called hypersialylation, is a common alteration found in cancer cells. Sialylated glycans can enhance immune evasion by interacting with sialic acid-binding immunoglobulin-like lectin (Siglec) receptors on tumor-infiltrating immune cells. Here, we investigated the effect of sialylated glycans and their interaction with Siglec receptors on myeloid-derived suppressor cells (MDSCs). We found that MDSCs derived from the blood of lung cancer patients and tumor-bearing mice strongly express ...
Source: Cellular and Molecular Immunology - March 6, 2024 Category: Molecular Biology Authors: Ronja Wieboldt Michael Sandholzer Emanuele Carlini Chia-Wei Lin Anastasiya B örsch Andreas Zingg Didier Lardinois Petra Herzig Leyla Don Alfred Zippelius Heinz L äubli Natalia Rodrigues Mantuano Source Type: research

Engagement of sialylated glycans with Siglec receptors on suppressive myeloid cells inhibits anticancer immunity via CCL2
Cell Mol Immunol. 2024 Mar 6. doi: 10.1038/s41423-024-01142-0. Online ahead of print.ABSTRACTThe overexpression of sialic acids on glycans, called hypersialylation, is a common alteration found in cancer cells. Sialylated glycans can enhance immune evasion by interacting with sialic acid-binding immunoglobulin-like lectin (Siglec) receptors on tumor-infiltrating immune cells. Here, we investigated the effect of sialylated glycans and their interaction with Siglec receptors on myeloid-derived suppressor cells (MDSCs). We found that MDSCs derived from the blood of lung cancer patients and tumor-bearing mice strongly express ...
Source: Cellular and Molecular Immunology - March 6, 2024 Category: Molecular Biology Authors: Ronja Wieboldt Michael Sandholzer Emanuele Carlini Chia-Wei Lin Anastasiya B örsch Andreas Zingg Didier Lardinois Petra Herzig Leyla Don Alfred Zippelius Heinz L äubli Natalia Rodrigues Mantuano Source Type: research

gp120-derived amyloidogenic peptides form amyloid fibrils that increase HIV-1 infectivity
We examined whether gp120 might serve as a precursor protein for the proteolytic release of amyloidogenic fragments that form amyloid fibrils, thereby promoting viral infection. Peptide array scanning, enzyme degradation assays, and viral infection experiments in vitro confirmed that many β-stranded peptides derived from gp120 can indeed form amyloid fibrils that increase HIV-1 infectivity. These gp120-derived amyloidogenic peptides, or GAPs, which were confirmed to form amyloid fibrils, were termed gp120-derived enhancers of viral infection (GEVIs). GEVIs specifically capture HIV-1 virions and promote their attachment to...
Source: Cellular and Molecular Immunology - March 5, 2024 Category: Molecular Biology Authors: Suiyi Tan Wenjuan Li Chan Yang Qingping Zhan Kunyu Lu Jun Liu Yong-Mei Jin Jin-Song Bai Lin Wang Jinqing Li Zhaofeng Li Fei Yu Yu-Ye Li Yue-Xun Duan Lu Lu Tong Zhang Jiaqi Wei Lin Li Yong-Tang Zheng Shibo Jiang Shuwen Liu Source Type: research

Development of NK cell-based cancer immunotherapies through receptor engineering
Cell Mol Immunol. 2024 Mar 5. doi: 10.1038/s41423-024-01145-x. Online ahead of print.ABSTRACTNatural killer (NK) cell-based immunotherapies are attracting increasing interest in the field of cancer treatment. Early clinical trials have shown promising outcomes, alongside satisfactory product efficacy and safety. Recent developments have greatly increased the therapeutic potential of NK cells by endowing them with enhanced recognition and cytotoxic capacities. This review focuses on surface receptor engineering in NK cell therapy and discusses its impact, challenges, and future directions.Most approaches are based on engine...
Source: Cellular and Molecular Immunology - March 5, 2024 Category: Molecular Biology Authors: Audrey Page Nicolas Chuvin Jenny Valladeau-Guilemond St éphane Depil Source Type: research

Author Correction: Tissue-resident macrophages exacerbate lung injury after remote sterile damage
Cell Mol Immunol. 2024 Mar 1. doi: 10.1038/s41423-024-01139-9. Online ahead of print.NO ABSTRACTPMID:38429370 | DOI:10.1038/s41423-024-01139-9 (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - March 1, 2024 Category: Molecular Biology Authors: Hanhui Zhong Jingjing Ji Jinling Zhuang Ziying Xiong Pengyun Xie Xiaolei Liu Jundi Zheng Wangli Tian Xiaoyang Hong Jing Tang Source Type: research

Author Correction: Tissue-resident macrophages exacerbate lung injury after remote sterile damage
Cell Mol Immunol. 2024 Mar 1. doi: 10.1038/s41423-024-01139-9. Online ahead of print.NO ABSTRACTPMID:38429370 | DOI:10.1038/s41423-024-01139-9 (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - March 1, 2024 Category: Molecular Biology Authors: Hanhui Zhong Jingjing Ji Jinling Zhuang Ziying Xiong Pengyun Xie Xiaolei Liu Jundi Zheng Wangli Tian Xiaoyang Hong Jing Tang Source Type: research

Author Correction: Tissue-resident macrophages exacerbate lung injury after remote sterile damage
Cell Mol Immunol. 2024 Mar 1. doi: 10.1038/s41423-024-01139-9. Online ahead of print.NO ABSTRACTPMID:38429370 | DOI:10.1038/s41423-024-01139-9 (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - March 1, 2024 Category: Molecular Biology Authors: Hanhui Zhong Jingjing Ji Jinling Zhuang Ziying Xiong Pengyun Xie Xiaolei Liu Jundi Zheng Wangli Tian Xiaoyang Hong Jing Tang Source Type: research