Olfactory immune response to SARS-CoV-2
Cell Mol Immunol. 2023 Dec 25. doi: 10.1038/s41423-023-01119-5. Online ahead of print.ABSTRACTNumerous pathogens can infect the olfactory tract, yet the pandemic caused by SARS-CoV-2 has strongly emphasized the importance of the olfactory mucosa as an immune barrier. Situated in the nasal passages, the olfactory mucosa is directly exposed to the environment to sense airborne odorants; however, this also means it can serve as a direct route of entry from the outside world into the brain. As a result, olfactotropic infections can have serious consequences, including dysfunction of the olfactory system, CNS invasion, dissemin...
Source: Cellular and Molecular Immunology - December 24, 2023 Category: Molecular Biology Authors: Sebastian A Wellford E Ashley Moseman Source Type: research
The RNA m < sup > 6 < /sup > A demethylase ALKBH5 drives emergency granulopoiesis and neutrophil mobilization by upregulating G-CSFR expression
Cell Mol Immunol. 2023 Dec 20. doi: 10.1038/s41423-023-01115-9. Online ahead of print.ABSTRACTEmergency granulopoiesis and neutrophil mobilization that can be triggered by granulocyte colony-stimulating factor (G-CSF) through its receptor G-CSFR are essential for antibacterial innate defense. However, the epigenetic modifiers crucial for intrinsically regulating G-CSFR expression and the antibacterial response of neutrophils remain largely unclear. N6-methyladenosine (m6A) RNA modification and the related demethylase alkB homolog 5 (ALKBH5) are key epigenetic regulators of immunity and inflammation, but their roles in neut...
Source: Cellular and Molecular Immunology - December 19, 2023 Category: Molecular Biology Authors: Yang Liu Renjie Song Zhike Lu Lu Zhao Xinyi Zhan Yini Li Xuetao Cao Source Type: research
Author Correction: Enhanced CD19 activity in B cells contributes to immunodeficiency in mice deficient in the ICF syndrome gene Zbtb24
Cell Mol Immunol. 2023 Dec 20. doi: 10.1038/s41423-023-01114-w. Online ahead of print.NO ABSTRACTPMID:38114748 | DOI:10.1038/s41423-023-01114-w (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - December 19, 2023 Category: Molecular Biology Authors: Zhengzhou Ying Swanand Hardikar Joshua B Plummer Tewfik Hamidi Bin Liu Yueping Chen Jianjun Shen Yunxiang Mu Kevin M McBride Taiping Chen Source Type: research
The RNA m < sup > 6 < /sup > A demethylase ALKBH5 drives emergency granulopoiesis and neutrophil mobilization by upregulating G-CSFR expression
Cell Mol Immunol. 2023 Dec 20. doi: 10.1038/s41423-023-01115-9. Online ahead of print.ABSTRACTEmergency granulopoiesis and neutrophil mobilization that can be triggered by granulocyte colony-stimulating factor (G-CSF) through its receptor G-CSFR are essential for antibacterial innate defense. However, the epigenetic modifiers crucial for intrinsically regulating G-CSFR expression and the antibacterial response of neutrophils remain largely unclear. N6-methyladenosine (m6A) RNA modification and the related demethylase alkB homolog 5 (ALKBH5) are key epigenetic regulators of immunity and inflammation, but their roles in neut...
Source: Cellular and Molecular Immunology - December 19, 2023 Category: Molecular Biology Authors: Yang Liu Renjie Song Zhike Lu Lu Zhao Xinyi Zhan Yini Li Xuetao Cao Source Type: research
Author Correction: Enhanced CD19 activity in B cells contributes to immunodeficiency in mice deficient in the ICF syndrome gene Zbtb24
Cell Mol Immunol. 2023 Dec 20. doi: 10.1038/s41423-023-01114-w. Online ahead of print.NO ABSTRACTPMID:38114748 | DOI:10.1038/s41423-023-01114-w (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - December 19, 2023 Category: Molecular Biology Authors: Zhengzhou Ying Swanand Hardikar Joshua B Plummer Tewfik Hamidi Bin Liu Yueping Chen Jianjun Shen Yunxiang Mu Kevin M McBride Taiping Chen Source Type: research
The RNA m < sup > 6 < /sup > A demethylase ALKBH5 drives emergency granulopoiesis and neutrophil mobilization by upregulating G-CSFR expression
Cell Mol Immunol. 2023 Dec 20. doi: 10.1038/s41423-023-01115-9. Online ahead of print.ABSTRACTEmergency granulopoiesis and neutrophil mobilization that can be triggered by granulocyte colony-stimulating factor (G-CSF) through its receptor G-CSFR are essential for antibacterial innate defense. However, the epigenetic modifiers crucial for intrinsically regulating G-CSFR expression and the antibacterial response of neutrophils remain largely unclear. N6-methyladenosine (m6A) RNA modification and the related demethylase alkB homolog 5 (ALKBH5) are key epigenetic regulators of immunity and inflammation, but their roles in neut...
Source: Cellular and Molecular Immunology - December 19, 2023 Category: Molecular Biology Authors: Yang Liu Renjie Song Zhike Lu Lu Zhao Xinyi Zhan Yini Li Xuetao Cao Source Type: research
Author Correction: Enhanced CD19 activity in B cells contributes to immunodeficiency in mice deficient in the ICF syndrome gene Zbtb24
Cell Mol Immunol. 2023 Dec 20. doi: 10.1038/s41423-023-01114-w. Online ahead of print.NO ABSTRACTPMID:38114748 | DOI:10.1038/s41423-023-01114-w (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - December 19, 2023 Category: Molecular Biology Authors: Zhengzhou Ying Swanand Hardikar Joshua B Plummer Tewfik Hamidi Bin Liu Yueping Chen Jianjun Shen Yunxiang Mu Kevin M McBride Taiping Chen Source Type: research
The RNA m < sup > 6 < /sup > A demethylase ALKBH5 drives emergency granulopoiesis and neutrophil mobilization by upregulating G-CSFR expression
Cell Mol Immunol. 2023 Dec 20. doi: 10.1038/s41423-023-01115-9. Online ahead of print.ABSTRACTEmergency granulopoiesis and neutrophil mobilization that can be triggered by granulocyte colony-stimulating factor (G-CSF) through its receptor G-CSFR are essential for antibacterial innate defense. However, the epigenetic modifiers crucial for intrinsically regulating G-CSFR expression and the antibacterial response of neutrophils remain largely unclear. N6-methyladenosine (m6A) RNA modification and the related demethylase alkB homolog 5 (ALKBH5) are key epigenetic regulators of immunity and inflammation, but their roles in neut...
Source: Cellular and Molecular Immunology - December 19, 2023 Category: Molecular Biology Authors: Yang Liu Renjie Song Zhike Lu Lu Zhao Xinyi Zhan Yini Li Xuetao Cao Source Type: research
Author Correction: Enhanced CD19 activity in B cells contributes to immunodeficiency in mice deficient in the ICF syndrome gene Zbtb24
Cell Mol Immunol. 2023 Dec 20. doi: 10.1038/s41423-023-01114-w. Online ahead of print.NO ABSTRACTPMID:38114748 | DOI:10.1038/s41423-023-01114-w (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - December 19, 2023 Category: Molecular Biology Authors: Zhengzhou Ying Swanand Hardikar Joshua B Plummer Tewfik Hamidi Bin Liu Yueping Chen Jianjun Shen Yunxiang Mu Kevin M McBride Taiping Chen Source Type: research
Thirteen years to get from b to a: one of the neglected isoforms of IL-37 enters the stage
Cell Mol Immunol. 2023 Dec 18. doi: 10.1038/s41423-023-01111-z. Online ahead of print.NO ABSTRACTPMID:38105292 | DOI:10.1038/s41423-023-01111-z (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - December 17, 2023 Category: Molecular Biology Authors: Steven X Cho Ina Rudloff Andrew M Ellisdon Claudia A Nold-Petry Marcel F Nold Source Type: research
Metabolic reprogramming by Syntenin-1 directs RA FLS and endothelial cell-mediated inflammation and angiogenesis
In conclusion, since the current therapies are ineffective on Syntenin-1 and SDC-1 expression in RA synovial tissue and blood, targeting this pathway and its interconnected metabolic intermediates may provide a novel therapeutic strategy.PMID:38105293 | DOI:10.1038/s41423-023-01108-8 (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - December 17, 2023 Category: Molecular Biology Authors: Anja Meyer Stephanie R Zack Wes Nijim Adel Burgos Vishwa Patel Brian Zanotti Michael V Volin M Asif Amin Myles J Lewis Costantino Pitzalis Shiva Arami Joseph A Karam Nadera J Sweiss Shiva Shahrara Source Type: research
Thirteen years to get from b to a: one of the neglected isoforms of IL-37 enters the stage
Cell Mol Immunol. 2023 Dec 18. doi: 10.1038/s41423-023-01111-z. Online ahead of print.NO ABSTRACTPMID:38105292 | DOI:10.1038/s41423-023-01111-z (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - December 17, 2023 Category: Molecular Biology Authors: Steven X Cho Ina Rudloff Andrew M Ellisdon Claudia A Nold-Petry Marcel F Nold Source Type: research
Metabolic reprogramming by Syntenin-1 directs RA FLS and endothelial cell-mediated inflammation and angiogenesis
In conclusion, since the current therapies are ineffective on Syntenin-1 and SDC-1 expression in RA synovial tissue and blood, targeting this pathway and its interconnected metabolic intermediates may provide a novel therapeutic strategy.PMID:38105293 | DOI:10.1038/s41423-023-01108-8 (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - December 17, 2023 Category: Molecular Biology Authors: Anja Meyer Stephanie R Zack Wes Nijim Adel Burgos Vishwa Patel Brian Zanotti Michael V Volin M Asif Amin Myles J Lewis Costantino Pitzalis Shiva Arami Joseph A Karam Nadera J Sweiss Shiva Shahrara Source Type: research
Thirteen years to get from b to a: one of the neglected isoforms of IL-37 enters the stage
Cell Mol Immunol. 2023 Dec 18. doi: 10.1038/s41423-023-01111-z. Online ahead of print.NO ABSTRACTPMID:38105292 | DOI:10.1038/s41423-023-01111-z (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - December 17, 2023 Category: Molecular Biology Authors: Steven X Cho Ina Rudloff Andrew M Ellisdon Claudia A Nold-Petry Marcel F Nold Source Type: research
Metabolic reprogramming by Syntenin-1 directs RA FLS and endothelial cell-mediated inflammation and angiogenesis
In conclusion, since the current therapies are ineffective on Syntenin-1 and SDC-1 expression in RA synovial tissue and blood, targeting this pathway and its interconnected metabolic intermediates may provide a novel therapeutic strategy.PMID:38105293 | DOI:10.1038/s41423-023-01108-8 (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - December 17, 2023 Category: Molecular Biology Authors: Anja Meyer Stephanie R Zack Wes Nijim Adel Burgos Vishwa Patel Brian Zanotti Michael V Volin M Asif Amin Myles J Lewis Costantino Pitzalis Shiva Arami Joseph A Karam Nadera J Sweiss Shiva Shahrara Source Type: research
