B-cell and antibody responses to SARS-CoV-2: infection, vaccination, and hybrid immunity
Cell Mol Immunol. 2023 Nov 10. doi: 10.1038/s41423-023-01095-w. Online ahead of print.ABSTRACTThe emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in 2019 prompted scientific, medical, and biotech communities to investigate infection- and vaccine-induced immune responses in the context of this pathogen. B-cell and antibody responses are at the center of these investigations, as neutralizing antibodies (nAbs) are an important correlate of protection (COP) from infection and the primary target of SARS-CoV-2 vaccine modalities. In addition to absolute levels, nAb longevity, neutralization breadth, imm...
Source: Cellular and Molecular Immunology - November 9, 2023 Category: Molecular Biology Authors: Dennis Lapuente Thomas H Winkler Matthias Tenbusch Source Type: research
New insights into the role of the immune inhibitory receptor VSTM1 in autoimmune disease
Cell Mol Immunol. 2023 Nov 7. doi: 10.1038/s41423-023-01097-8. Online ahead of print.NO ABSTRACTPMID:37935837 | DOI:10.1038/s41423-023-01097-8 (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - November 7, 2023 Category: Molecular Biology Authors: Naijun Miao Jing Wang Source Type: research
New insights into the role of the immune inhibitory receptor VSTM1 in autoimmune disease
Cell Mol Immunol. 2023 Nov 7. doi: 10.1038/s41423-023-01097-8. Online ahead of print.NO ABSTRACTPMID:37935837 | DOI:10.1038/s41423-023-01097-8 (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - November 7, 2023 Category: Molecular Biology Authors: Naijun Miao Jing Wang Source Type: research
New insights into the role of the immune inhibitory receptor VSTM1 in autoimmune disease
Cell Mol Immunol. 2023 Nov 7. doi: 10.1038/s41423-023-01097-8. Online ahead of print.NO ABSTRACTPMID:37935837 | DOI:10.1038/s41423-023-01097-8 (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - November 7, 2023 Category: Molecular Biology Authors: Naijun Miao Jing Wang Source Type: research
Mitochondrial DNA-triggered innate immune response: mechanisms and diseases
Cell Mol Immunol. 2023 Nov 7. doi: 10.1038/s41423-023-01086-x. Online ahead of print.ABSTRACTVarious cellular stress conditions trigger mitochondrial DNA (mtDNA) release from mitochondria into the cytosol. The released mtDNA is sensed by the cGAS-MITA/STING pathway, resulting in the induced expression of type I interferon and other effector genes. These processes contribute to the innate immune response to viral infection and other stress factors. The deregulation of these processes causes autoimmune diseases, inflammatory metabolic disorders and cancer. Therefore, the cGAS-MITA/STING pathway is a potential target for inte...
Source: Cellular and Molecular Immunology - November 6, 2023 Category: Molecular Biology Authors: Ming-Ming Hu Hong-Bing Shu Source Type: research
The OX40-TRAF6 axis promotes CTLA-4 degradation to augment antitumor CD8 < sup > + < /sup > T-cell immunity
Cell Mol Immunol. 2023 Nov 7. doi: 10.1038/s41423-023-01093-y. Online ahead of print.ABSTRACTImmune checkpoint blockade (ICB), including anti-cytotoxic T-lymphocyte associated protein 4 (CTLA-4), benefits only a limited number of patients with cancer. Understanding the in-depth regulatory mechanism of CTLA-4 protein stability and its functional significance may help identify ICB resistance mechanisms and assist in the development of novel immunotherapeutic modalities to improve ICB efficacy. Here, we identified that TNF receptor-associated factor 6 (TRAF6) mediates Lys63-linked ubiquitination and subsequent lysosomal degra...
Source: Cellular and Molecular Immunology - November 6, 2023 Category: Molecular Biology Authors: Jizhang Yu Jikai Cui Xi Zhang Heng Xu Zhang Chen Yuan Li Yuqing Niu Song Wang Shuan Ran Yanqiang Zou Weicong Ye Dan Zhang Cheng Zhou Jiahong Xia Jie Wu Source Type: research
Mitochondrial DNA-triggered innate immune response: mechanisms and diseases
Cell Mol Immunol. 2023 Nov 7. doi: 10.1038/s41423-023-01086-x. Online ahead of print.ABSTRACTVarious cellular stress conditions trigger mitochondrial DNA (mtDNA) release from mitochondria into the cytosol. The released mtDNA is sensed by the cGAS-MITA/STING pathway, resulting in the induced expression of type I interferon and other effector genes. These processes contribute to the innate immune response to viral infection and other stress factors. The deregulation of these processes causes autoimmune diseases, inflammatory metabolic disorders and cancer. Therefore, the cGAS-MITA/STING pathway is a potential target for inte...
Source: Cellular and Molecular Immunology - November 6, 2023 Category: Molecular Biology Authors: Ming-Ming Hu Hong-Bing Shu Source Type: research
The OX40-TRAF6 axis promotes CTLA-4 degradation to augment antitumor CD8 < sup > + < /sup > T-cell immunity
Cell Mol Immunol. 2023 Nov 7. doi: 10.1038/s41423-023-01093-y. Online ahead of print.ABSTRACTImmune checkpoint blockade (ICB), including anti-cytotoxic T-lymphocyte associated protein 4 (CTLA-4), benefits only a limited number of patients with cancer. Understanding the in-depth regulatory mechanism of CTLA-4 protein stability and its functional significance may help identify ICB resistance mechanisms and assist in the development of novel immunotherapeutic modalities to improve ICB efficacy. Here, we identified that TNF receptor-associated factor 6 (TRAF6) mediates Lys63-linked ubiquitination and subsequent lysosomal degra...
Source: Cellular and Molecular Immunology - November 6, 2023 Category: Molecular Biology Authors: Jizhang Yu Jikai Cui Xi Zhang Heng Xu Zhang Chen Yuan Li Yuqing Niu Song Wang Shuan Ran Yanqiang Zou Weicong Ye Dan Zhang Cheng Zhou Jiahong Xia Jie Wu Source Type: research
Author Correction: MST4 kinase regulates immune thrombocytopenia by phosphorylating STAT1-mediated M1 polarization of macrophages
Cell Mol Immunol. 2023 Oct 31. doi: 10.1038/s41423-023-01094-x. Online ahead of print.NO ABSTRACTPMID:37907780 | DOI:10.1038/s41423-023-01094-x (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - November 1, 2023 Category: Molecular Biology Authors: Jingjing Cao Lili Ji Yanxia Zhan Xia Shao Pengcheng Xu Boting Wu Pu Chen Luya Cheng Xibing Zhuang Yang Ou Fanli Hua Lihua Sun Feng Li Hao Chen Zhaocai Zhou Yunfeng Cheng Source Type: research
Author Correction: MST4 kinase regulates immune thrombocytopenia by phosphorylating STAT1-mediated M1 polarization of macrophages
Cell Mol Immunol. 2023 Oct 31. doi: 10.1038/s41423-023-01094-x. Online ahead of print.NO ABSTRACTPMID:37907780 | DOI:10.1038/s41423-023-01094-x (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - November 1, 2023 Category: Molecular Biology Authors: Jingjing Cao Lili Ji Yanxia Zhan Xia Shao Pengcheng Xu Boting Wu Pu Chen Luya Cheng Xibing Zhuang Yang Ou Fanli Hua Lihua Sun Feng Li Hao Chen Zhaocai Zhou Yunfeng Cheng Source Type: research
Author Correction: MST4 kinase regulates immune thrombocytopenia by phosphorylating STAT1-mediated M1 polarization of macrophages
Cell Mol Immunol. 2023 Oct 31. doi: 10.1038/s41423-023-01094-x. Online ahead of print.NO ABSTRACTPMID:37907780 | DOI:10.1038/s41423-023-01094-x (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - November 1, 2023 Category: Molecular Biology Authors: Jingjing Cao Lili Ji Yanxia Zhan Xia Shao Pengcheng Xu Boting Wu Pu Chen Luya Cheng Xibing Zhuang Yang Ou Fanli Hua Lihua Sun Feng Li Hao Chen Zhaocai Zhou Yunfeng Cheng Source Type: research
Author Correction: MST4 kinase regulates immune thrombocytopenia by phosphorylating STAT1-mediated M1 polarization of macrophages
Cell Mol Immunol. 2023 Oct 31. doi: 10.1038/s41423-023-01094-x. Online ahead of print.NO ABSTRACTPMID:37907780 | DOI:10.1038/s41423-023-01094-x (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - November 1, 2023 Category: Molecular Biology Authors: Jingjing Cao Lili Ji Yanxia Zhan Xia Shao Pengcheng Xu Boting Wu Pu Chen Luya Cheng Xibing Zhuang Yang Ou Fanli Hua Lihua Sun Feng Li Hao Chen Zhaocai Zhou Yunfeng Cheng Source Type: research
Author Correction: MST4 kinase regulates immune thrombocytopenia by phosphorylating STAT1-mediated M1 polarization of macrophages
Cell Mol Immunol. 2023 Oct 31. doi: 10.1038/s41423-023-01094-x. Online ahead of print.NO ABSTRACTPMID:37907780 | DOI:10.1038/s41423-023-01094-x (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - November 1, 2023 Category: Molecular Biology Authors: Jingjing Cao Lili Ji Yanxia Zhan Xia Shao Pengcheng Xu Boting Wu Pu Chen Luya Cheng Xibing Zhuang Yang Ou Fanli Hua Lihua Sun Feng Li Hao Chen Zhaocai Zhou Yunfeng Cheng Source Type: research
The nuclear cytokine IL-37a controls lethal cytokine storms primarily via IL-1R8-independent transcriptional upregulation of PPAR γ
Cell Mol Immunol. 2023 Oct 27. doi: 10.1038/s41423-023-01091-0. Online ahead of print.ABSTRACTCytokine storms are crucial in the development of various inflammatory diseases, including sepsis and autoimmune disorders. The immunosuppressive cytokine INTERLEUKIN (IL)-37 consists of five isoforms (IL-37a-e). We identified IL-37a as a nuclear cytokine for the first time. Compared to IL-37b, IL-37a demonstrated greater efficacy in protecting against Toll-like receptor-induced cytokine hypersecretion and lethal endotoxic shock. The full-length (FL) form of IL-37a and the N-terminal fragment, which is processed by elastase, could...
Source: Cellular and Molecular Immunology - October 27, 2023 Category: Molecular Biology Authors: Rongfei Wei Xiao Han Mengyuan Li Yuan Ji Lianfeng Zhang Maria-Ioanna Christodoulou Najwa Jameel Hameed Aga Caiyan Zhang Ran Gao Jiangning Liu Jinrong Fu Guoping Lu Xiaojun Xiao Xiaoyu Liu Ping-Chang Yang Iain B McInnes Ying Sun Peisong Gao Chuan Qin Shau- Source Type: research
The nuclear cytokine IL-37a controls lethal cytokine storms primarily via IL-1R8-independent transcriptional upregulation of PPAR γ
Cell Mol Immunol. 2023 Oct 27. doi: 10.1038/s41423-023-01091-0. Online ahead of print.ABSTRACTCytokine storms are crucial in the development of various inflammatory diseases, including sepsis and autoimmune disorders. The immunosuppressive cytokine INTERLEUKIN (IL)-37 consists of five isoforms (IL-37a-e). We identified IL-37a as a nuclear cytokine for the first time. Compared to IL-37b, IL-37a demonstrated greater efficacy in protecting against Toll-like receptor-induced cytokine hypersecretion and lethal endotoxic shock. The full-length (FL) form of IL-37a and the N-terminal fragment, which is processed by elastase, could...
Source: Cellular and Molecular Immunology - October 27, 2023 Category: Molecular Biology Authors: Rongfei Wei Xiao Han Mengyuan Li Yuan Ji Lianfeng Zhang Maria-Ioanna Christodoulou Najwa Jameel Hameed Aga Caiyan Zhang Ran Gao Jiangning Liu Jinrong Fu Guoping Lu Xiaojun Xiao Xiaoyu Liu Ping-Chang Yang Iain B McInnes Ying Sun Peisong Gao Chuan Qin Shau- Source Type: research
