Mapping the Mutation Landscape of Colorectal Cancer.
PMID: 31655711 [PubMed - in process] (Source: The American Journal of the Medical Sciences)
Source: The American Journal of the Medical Sciences - October 29, 2019 Category: General Medicine Authors: Newsom KJ, Starostik P Tags: Am J Med Sci Source Type: research

Are We Ready to Move Beyond Capillary Glucose Testing and Insulin Injections?
PMID: 31655712 [PubMed - in process] (Source: The American Journal of the Medical Sciences)
Source: The American Journal of the Medical Sciences - October 29, 2019 Category: General Medicine Authors: Galindo RJ, Migdal AL, Umpierrez GE Tags: Am J Med Sci Source Type: research

Why Did the United States Medical School Admissions Quota for Jews End?
Abstract At the end of World War II anti-Semitism was pervasive in the United States. Quotas to limit the number of Jewish students were put in place at most U.S. medical schools in the 1920s and were well-entrenched by 1945. By 1970 the quota was gone. Why? Multiple factors contributed to the end of the quota. First, attitudes toward Jews shifted as Americans recoiled from the horrors of the Holocaust and over half a million Jewish GIs returned home from World War II. Many entered the higher education system. Second, governmental and private investigations in New York City, New York State and Philadelphia exposed...
Source: The American Journal of the Medical Sciences - October 29, 2019 Category: General Medicine Authors: Halperin EC Tags: Am J Med Sci Source Type: research

Insulin Pumps: Review of Technological Advancement in Diabetes Management.
Abstract Insulin pump therapy, also known as continuous subcutaneous insulin infusion (CSII) therapy is an evolving form of insulin delivery which has been shown to be highly effective in maintaining euglycemia and providing patients with flexibility in their lives. It functions by providing the patient with a continuous subcutaneous infusion of a rapid acting insulin and allows the patient to administer boluses throughout the day for food and correction of high glucose levels. CSII is approved in patients with type 1 diabetes and selected patients with type 2 diabetes; however, it is important to select the right...
Source: The American Journal of the Medical Sciences - October 29, 2019 Category: General Medicine Authors: Sora ND, Shashpal F, Bond EA, Jenkins AJ Tags: Am J Med Sci Source Type: research

The Natural History of Iron Deficiency Anemia.
Abstract BACKGROUND: Current evidence suggests that adult men and nonmenstruating women with iron deficiency anemia (IDA) should undergo gastrointestinal (GI) evaluation to detect a potential bleeding lesion. We hypothesized that after endoscopic evaluation and treatment, IDA would be expected to resolve. Thus, we aimed to understand the natural history of IDA, in particular long-term outcomes. MATERIALS AND METHODS: Adult patients with IDA (defined as anemia and ferritin
Source: The American Journal of the Medical Sciences - October 29, 2019 Category: General Medicine Authors: Dickey S, Rockey DC Tags: Am J Med Sci Source Type: research

Outcome of Anticoagulation Therapy of Left Atrial Thrombus or Sludge in Patients With Nonvalvular Atrial Fibrillation or Flutter.
CONCLUSIONS: Compared with warfarin, dabigatran and rivaroxaban can also effectively resolve LA thrombus or sludge with no significant differences. Increasing the duration of anticoagulation, determining the optimal dosage of anticoagulants, and switching to another anticoagulant when necessary could be considered to improve treatment effectiveness. PMID: 31543101 [PubMed - in process] (Source: The American Journal of the Medical Sciences)
Source: The American Journal of the Medical Sciences - September 25, 2019 Category: General Medicine Authors: Yang Y, Du X, Dong J, Ma C Tags: Am J Med Sci Source Type: research

Influenza With Community-Associated Methicillin-Resistant Staphylococcus Aureus Pneumonia.
Abstract Patients with community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) pneumonia have poor clinical outcomes and high frequency of mortality, especially in patents with postinfluenza infection. Herein, we report a case of community-acquired pneumonia with multiple organ failure in a 51-year-old patient with initial presentation of flu-like symptoms. The influenza rapid test from the specimen of nasopharyngeal swab was positive for type B influenza virus and was confirmed by real-time polymerase chain reaction. Gram stain of bronchoalveolar lavage fluid revealed gram positive cocci in gro...
Source: The American Journal of the Medical Sciences - September 25, 2019 Category: General Medicine Authors: Liu CW, Lin SP, Wang WY, Huang YH Tags: Am J Med Sci Source Type: research

Beware Energy Drinks: A Case of a Toxic Triad Syndrome in a Diabetic Patient With Nonalcoholic Fatty Liver Disease.
We present the cautionary case of a 46-year-old Caucasian man with well-controlled type 2 diabetes and nonalcoholic fatty liver disease who developed a toxic triad syndrome of gastritis, hepatitis and pancreatitis within 4 months of commencing daily consumption of 2-3 160z cans of the energy drink Monster Energy. His clinical symptoms and biochemical derangements promptly resolved with stopping the beverage. We discuss the potential risks inherent in unsupervised liberal consumption of energy drinks and the need for both caution and vigilance among clinicians and patients. PMID: 31543103 [PubMed - in process] (Source:...
Source: The American Journal of the Medical Sciences - September 25, 2019 Category: General Medicine Authors: Uwaifo GI Tags: Am J Med Sci Source Type: research

Discovery of Aberrant Alteration of Genome in Colorectal Cancer by Exome Sequencing.
CONCLUSIONS: We frequently found novel genes ZNF717, ZNF493, CDR1, ARMC4 and SUMF2 and gains in 10q25.3, which may be functional mutation in CRC. The high-frequency private events such as SNVs confirm the highly heterogeneous mutations found in CRCs. The mutated genes sites in different patients may vary significantly, which may also be more challenging for clinical treatment. PMID: 31445671 [PubMed - as supplied by publisher] (Source: The American Journal of the Medical Sciences)
Source: The American Journal of the Medical Sciences - August 1, 2019 Category: General Medicine Authors: Liang Y, Jiang L, Zhong X, Hochwald SN, Wang Y, Huang L, Nie Q, Huang H, Xu JF Tags: Am J Med Sci Source Type: research

Efficacy and Safety of Vitamin D Supplementation in Patients With Systemic Lupus Erythematosus: A Meta-analysis of Randomized Controlled Trials.
Abstract BACKGROUND: The efficacy of vitamin D supplementation in patients with systemic lupus erythematosus (SLE) remains uncertain. This meta-analysis aimed to systematically evaluate the efficacy and safety of vitamin D supplementation in patients with SLE. MATERIALS AND METHODS: Randomized controlled trials (RCTs) were searched in PubMed, Embase, Cochrane CENTRAL and Web of Science databases. The retrieved studies were subjected to meta-analysis using the fixed-effect or random-effect model. RESULTS: Five eligible RCTs enrolling 490 participants were included. Compared to the placebo treatment, vitam...
Source: The American Journal of the Medical Sciences - July 26, 2019 Category: General Medicine Authors: Zheng R, Gonzalez A, Yue J, Wu X, Qiu M, Gui L, Zhu S, Huang L Tags: Am J Med Sci Source Type: research

Laboratory Discrimination Between Neutrophilic Malignant and Parapneumonic Pleural Effusions.
This study investigated objective laboratory findings to help distinguish neutrophilic MPE from PPE. MATERIALS AND METHODS: A retrospective study was conducted on patients with neutrophilic MPE and PPE. Routine blood and pleural fluid data of the 2 groups were compared, and the diagnostic performances of predictors for neutrophilic MPE were assessed using receiver-operating characteristic curves. RESULTS: Forty-one and 140 patients with neutrophilic MPE and PPE, respectively, were included. In final analysis, serum C-reactive protein, pleural fluid neutrophil-to-lymphocyte ratio, and pleural fluid carcinoembryoni...
Source: The American Journal of the Medical Sciences - July 26, 2019 Category: General Medicine Authors: Lee J, Lee YH, Seo H, Lee H, Kim YK, Yoo SS, Lee SY, Cha SI, Park JY, Kim CH Tags: Am J Med Sci Source Type: research

Ethnicity and Diabetic Quality-of-Life.
CONCLUSIONS: Diabetes-related QOL was similar in matched cohorts of adult white and black participants with diabetes mellitus. This study suggests utilities for diabetes mellitus can be used in economic analyses without adjustment for white and black ethnicity. PMID: 31331449 [PubMed - in process] (Source: The American Journal of the Medical Sciences)
Source: The American Journal of the Medical Sciences - July 26, 2019 Category: General Medicine Authors: Brown GC, Brown MM, Sharma S Tags: Am J Med Sci Source Type: research

When Do Clinicians Follow-up Abnormal Liver Tests in Primary Care?
CONCLUSIONS: A large proportion of patients with abnormal liver tests still lack repeat testing at 1 year. The number of liver abnormal liver tests and degree of elevation were inversely associated with the time to repeat testing. PMID: 31331450 [PubMed - in process] (Source: The American Journal of the Medical Sciences)
Source: The American Journal of the Medical Sciences - July 26, 2019 Category: General Medicine Authors: Schreiner AD, Bian J, Zhang J, Kirkland EB, Heincelman ME, Schumann SO, Mauldin PD, Moran WP, Rockey DC Tags: Am J Med Sci Source Type: research

Comprehensive Analysis of Temperature in Hospitalized Patients.
Abstract BACKGROUND: Human body temperature is believed to be linked to clinical diagnoses. However, most of the available data stems from healthy individuals, with no large-scale studies addressing body temperature in the inpatient setting, which is the focus of our study. MATERIALS AND METHODS: This is a retrospective analysis of a total of 695,107 temperature readings from 16,245 patients hospitalized over a 1-year period at a tertiary medical center, ages 0-105 years, 50% female, with rectal, monotherm, axillary, oral, temporal and tympanic measurement sites. The average temperature (Tave) per patient and...
Source: The American Journal of the Medical Sciences - July 26, 2019 Category: General Medicine Authors: Geneva II, Cuzzo B, Fazili T, Javaid W Tags: Am J Med Sci Source Type: research

Trends in Out-of-Pocket Burden in United States Adults with Kidney Disease: 2002-2011.
CONCLUSIONS: Though high OOP burden declined between 2002 and 2011 in the US population with KD, most of the decline was among the publicly insured, so the uninsured populations with KD remain vulnerable. Providers and policy makers should be aware of the vulnerability of uninsured individuals with KD to high OOP burden. PMID: 31331452 [PubMed - in process] (Source: The American Journal of the Medical Sciences)
Source: The American Journal of the Medical Sciences - July 26, 2019 Category: General Medicine Authors: Ozieh MN, Bishu KG, Dismuke CE, Egede LE Tags: Am J Med Sci Source Type: research

Delayed Respiratory Distress in a Patient With Chronic Obstructive Pulmonary Disease After Abdominal Surgery.
Abstract Patients with chronic obstructive pulmonary disease (COPD) are at increased risk for perioperative complications. The frequency of complications depends on the severity of COPD, the type of anesthesia used, the surgical site, and other comorbidities. Patients undergoing upper abdominal surgery have significant changes in lung volumes, likely secondary to changes in diaphragm function and abdominal pain, and these changes increase the risk for complications, including acute respiratory failure, atelectasis, pneumonia and unplanned reintubation. We discuss a patient with COPD who did well for the first 3 da...
Source: The American Journal of the Medical Sciences - July 26, 2019 Category: General Medicine Authors: Riccione A, Nugent K Tags: Am J Med Sci Source Type: research

Primary Diffuse Large B-Cell Lymphoma of the Descending Colon.
Abstract Primary non-Hodgkin lymphoma of the gastrointestinal tract is rare with an incidence of 10-15% of all non-Hodgkin lymphoma cases and 1-4% of all gastrointestinal tumors. The most common sites of involvement include the stomach, small intestines, colon and rectum. Primary colorectal lymphoma is extremely rare representing only 0.2-0.6% of all colorectal malignancies. The presentation is usually non-specific leading to delay in diagnosis. Imaging is used to locate the tumor and its extension. Colonoscopy usually shows a fungating mass, infiltrative or ulcerative lesion. Diffuse large B-cell lymphoma is the ...
Source: The American Journal of the Medical Sciences - July 26, 2019 Category: General Medicine Authors: Sharma B, Pavelock N, Antoine M, Shah M, Galbraith K, Rawlins S Tags: Am J Med Sci Source Type: research

Epidemiology of Sarcopenia and Factors Associated With It Among Community-Dwelling Older Adults in Taiwan [Am J Med Sci. 2019; 357(2):124-133].
PMID: 31331455 [PubMed - in process] (Source: The American Journal of the Medical Sciences)
Source: The American Journal of the Medical Sciences - July 26, 2019 Category: General Medicine Authors: Kuo YH, Wang TF, Liu LK, Lee WJ, Peng LN, Chen LK Tags: Am J Med Sci Source Type: research

Notice of Overlapping Publication: Priority for Treatment and Intensive Care of Patients With Nonsevere Community-Acquired Pneumonia [Li et al. Am J Med Sci, 2018; 356(4):329].
Authors: PMID: 31331456 [PubMed - in process] (Source: The American Journal of the Medical Sciences)
Source: The American Journal of the Medical Sciences - July 26, 2019 Category: General Medicine Tags: Am J Med Sci Source Type: research

Evolving Field of Long-term Antithrombotic Therapy After Percutaneous Coronary Intervention in Patients With Atrial Fibrillation.
PMID: 31331457 [PubMed - in process] (Source: The American Journal of the Medical Sciences)
Source: The American Journal of the Medical Sciences - July 26, 2019 Category: General Medicine Authors: O Kiviniemi T Tags: Am J Med Sci Source Type: research

Systemic Lupus Erythematosus and Vitamin D: Should We Recommend That Our Patients Take Supplements?
PMID: 31331458 [PubMed - in process] (Source: The American Journal of the Medical Sciences)
Source: The American Journal of the Medical Sciences - July 26, 2019 Category: General Medicine Authors: Winters SJ Tags: Am J Med Sci Source Type: research

Rofecoxib and Clinically Significant Gastrointestinal Events: Response.
PMID: 31301755 [PubMed - as supplied by publisher] (Source: The American Journal of the Medical Sciences)
Source: The American Journal of the Medical Sciences - July 10, 2019 Category: General Medicine Authors: Graham DY, Jewell NP, Chan FKL Tags: Am J Med Sci Source Type: research

Prognostic Significance of In-hospital Acquired Thrombocytopenia in Stable Coronary Artery Disease Undergoing Percutaneous Coronary Intervention.
Abstract BACKGROUND: This large cohort study aimed to investigate the effect of acquired thrombocytopenia on the prognosis of patients with stable coronary artery disease undergoing percutaneous coronary intervention (PCI). MATERIALS AND METHODS: Patients with stable coronary artery disease undergoing elective PCI were prospectively enrolled during 2013. All patients were followed for a median of 30 months (the 25th and 75th percentiles for follow-up time were 27 and 32 months). After excluding patients with baseline thrombocytopenia (
Source: The American Journal of the Medical Sciences - June 24, 2019 Category: General Medicine Authors: Jiang P, Gao Z, Zhao W, Song Y, Tang X, Xu J, Wang H, Jiang L, Chen J, Qiao S, Yang Y, Gao R, Xu B, Yuan J Tags: Am J Med Sci Source Type: research

Presentation of the 2019 SSCI Founders' Medal Award.
PMID: 31228967 [PubMed - in process] (Source: The American Journal of the Medical Sciences)
Source: The American Journal of the Medical Sciences - June 24, 2019 Category: General Medicine Authors: Lee Hamm L Tags: Am J Med Sci Source Type: research

2019 SSCI Founders' Medal Award Acceptance Address.
PMID: 31228968 [PubMed - in process] (Source: The American Journal of the Medical Sciences)
Source: The American Journal of the Medical Sciences - June 24, 2019 Category: General Medicine Authors: Krousel-Wood M Tags: Am J Med Sci Source Type: research

Southern Society for Clinical Investigation 2019 Newly Elected Members.
Authors: PMID: 31228969 [PubMed - in process] (Source: The American Journal of the Medical Sciences)
Source: The American Journal of the Medical Sciences - June 24, 2019 Category: General Medicine Tags: Am J Med Sci Source Type: research

Southern Society for Clinical Investigation 2019 Award Recipients.
Authors: PMID: 31228970 [PubMed - in process] (Source: The American Journal of the Medical Sciences)
Source: The American Journal of the Medical Sciences - June 24, 2019 Category: General Medicine Tags: Am J Med Sci Source Type: research

Southern Society for Clinical Investigation Nephrology Young Investigators' Forum.
Authors: PMID: 31228971 [PubMed - in process] (Source: The American Journal of the Medical Sciences)
Source: The American Journal of the Medical Sciences - June 24, 2019 Category: General Medicine Tags: Am J Med Sci Source Type: research

Other Societies Represented at the Southern Regional Meeting.
Authors: PMID: 31228972 [PubMed - in process] (Source: The American Journal of the Medical Sciences)
Source: The American Journal of the Medical Sciences - June 24, 2019 Category: General Medicine Tags: Am J Med Sci Source Type: research

The Association of Salivary Biomarkers With the Severity of Obstructive Sleep Apnea and Concomitant Hypertension.
Abstract BACKGROUND: We aimed to assess the association between salivary alpha-amylase and salivary cortisol, and obstructive sleep apnea (OSA) severity. METHODS: Fifty-eight adults with suspected OSA were divided into the following 4 groups based on the apnea hypopnea index (AHI): control (AHI
Source: The American Journal of the Medical Sciences - May 29, 2019 Category: General Medicine Authors: Yan YR, Zhang L, Lin YN, Wei Y, Li N, Sun XW, Zhou JP, Li QY Tags: Am J Med Sci Source Type: research

Recognition and Management of Medication Excipient Reactivity in Patients With Mast Cell Activation Syndrome.
We present a series of patients with MCAS to illustrate important points regarding excipient reactivity which may be useful in everyday practice. PMID: 31126513 [PubMed - in process] (Source: The American Journal of the Medical Sciences)
Source: The American Journal of the Medical Sciences - May 29, 2019 Category: General Medicine Authors: Schofield JR, Afrin LB Tags: Am J Med Sci Source Type: research

Update on PulmonaryFibrosis: Great Advancements, but Still Searching forAnswers.
PMID: 31010460 [PubMed - in process] (Source: The American Journal of the Medical Sciences)
Source: The American Journal of the Medical Sciences - April 25, 2019 Category: General Medicine Authors: Roman J Tags: Am J Med Sci Source Type: research

Idiopathic Pulmonary Fibrosis: Epidemiology, Diagnosis andOutcomes.
Abstract The incidence and prevalence of idiopathic pulmonary fibrosis (IPF) is increasing worldwide. This, combined with its poor prognosis and unpredictable natural history, has amplified the importance of an accurate diagnosis and monitoring. A diagnosis of exclusion, IPF requires a comprehensive clinical evaluation. This results in a clinical context that provides the backdrop for interpretation of the chest imaging and histopathology. A confident or probable usual interstitial pneumonia chest imaging pattern on high-resolution computerized tomography may be diagnostic in the correct clinical context. Outcomes...
Source: The American Journal of the Medical Sciences - April 25, 2019 Category: General Medicine Authors: Wakwaya Y, Brown KK Tags: Am J Med Sci Source Type: research

Current and Future Idiopathic Pulmonary Fibrosis Therapy.
The objective of this review is both to describe the current therapies approved for the treatment of IPF and the emerging therapeutic approaches. Currently, nintedanib and pirfenidone are the basis of IPF therapy, based on the results of large randomized clinical trials showing their safety and efficacy in reducing disease progression. Nonetheless, the ideal IPF therapy is still lacking and trials are underway to test new therapeutic targets. The near future could bring to clinicians and patients a combined therapeutic strategy, hitting the disease from several simultaneous pathways and hopefully leading to clinical stabil...
Source: The American Journal of the Medical Sciences - April 25, 2019 Category: General Medicine Authors: Richeldi L, Baldi F, Pasciuto G, Macagno F, Panico L Tags: Am J Med Sci Source Type: research

Epithelial Injury and Dysfunction in the Pathogenesis of Idiopathic PulmonaryFibrosis.
Abstract Idiopathic pulmonary fibrosis is a disease of older adults leading to progressive dyspnea and reduced exercise capacity, typically resulting in death within 3-5years of diagnosis. Underlying genetic susceptibility combined with environmental insults is proposed to trigger a chronic wound repair response, leading to activation of the fibrotic cascade. Perturbations in several molecular pathways mediate vulnerability of the alveolar epithelium to injurious agents, including the unfolded protein response, autophagy, mitophagy, and cellular senescence. These cellular responses are intricately intertwined and ...
Source: The American Journal of the Medical Sciences - April 25, 2019 Category: General Medicine Authors: Winters NI, Burman A, Kropski JA, Blackwell TS Tags: Am J Med Sci Source Type: research

Genetics of Idiopathic Pulmonary Fibrosis.
Abstract Idiopathic pulmonary fibrosis (IPF) is the most common form of interstitial lung disease. IPF is a complex disease, with environmental and genetic factors variably contributing to disease susceptibility and outcomes. A host of common gene variants with modest effect size impart disease risk in patients with sporadic IPF, while rare variants with large effect size influence disease risk in those with familial interstitial pneumonia. In this review, we highlight several common and rare variants underpinning IPF risk and call attention to recently published studies informing our understanding of this risk. ...
Source: The American Journal of the Medical Sciences - April 25, 2019 Category: General Medicine Authors: Barros A, Oldham J, Noth I Tags: Am J Med Sci Source Type: research

The Aging Lung and Idiopathic Pulmonary Fibrosis.
Abstract Idiopathic pulmonary fibrosis (IPF) is one of many clinical syndromes that are associated with aging, and is increasing in both incidence and prevalence with the rapid rise in aging populations world-wide. There is accumulating data on how the biology of aging may influence the susceptibility to lung fibrosis in the elderly. In this review, we explore some of the known "hallmarks of aging," including telomere attrition, genomic instability, epigenetic alterations, loss of proteostasis, cellular senescence and mitochondrial dysfunction in the pathobiology of IPF. Additionally, we discuss age-asso...
Source: The American Journal of the Medical Sciences - April 25, 2019 Category: General Medicine Authors: Gulati S, Thannickal VJ Tags: Am J Med Sci Source Type: research

Multipotent Mesenchymal Stromal Cells for Pulmonary Fibrosis?
Abstract With the combination of ideologic beliefs and the will to survive, fraught patients and determined clinicians seek alternative therapies for treatment of terminal conditions, such as idiopathic pulmonary fibrosis. Unfortunately, the need for treatment has supported the growth of unapproved stem cell therapy over the years spanning across many countries. The reality, however, is that the science behind this therapy is lagging. While there have been promising results from phase I trials, there remain multiple reasons that "stem cells" are not ready for clinical application, starting from a gap in ...
Source: The American Journal of the Medical Sciences - April 25, 2019 Category: General Medicine Authors: Purdon S, Patete CL, Glassberg MK Tags: Am J Med Sci Source Type: research

The Fibrosis Across Organs Symposium: A Roadmap for Future Research Priorities.
PMID: 31010467 [PubMed - in process] (Source: The American Journal of the Medical Sciences)
Source: The American Journal of the Medical Sciences - April 25, 2019 Category: General Medicine Authors: Roman J, Barnes TR, Kervitsky DJ, Cosgrove GP, Doherty DE, Tager AM, Richeldi L, White ES, Brenner DA, Schnapp LM, Hewitson TD, Jugdutt BI, McKinsey TA, Tosi JD, Crane S, Brown KK, Fibrosis Across Organs Symposium Working Group Tags: Am J Med Sci Source Type: research

Differences in Monocyte Subsets and Monocyte-Platelet Aggregates in Acute Myocardial Infarction-PreliminaryResults.
CONCLUSIONS: These findings suggest that the increase in circulating levels of classical monocytes in patients with STEMI as compared to NSTEMI reflects the severity of the acute event. The increased percentage of MPAs may favor the development of STEMI compared to NSTEMI. PMID: 31010468 [PubMed - in process] (Source: The American Journal of the Medical Sciences)
Source: The American Journal of the Medical Sciences - April 25, 2019 Category: General Medicine Authors: Kamińska J, Lisowska A, Koper-Lenkiewicz OM, Mikłasz P, Grubczak K, Moniuszko M, Kiszło P, Kemona H, Dymicka-Piekarska V Tags: Am J Med Sci Source Type: research

SCIT Versus SLIT: Which One Do You Recommend, Doc?
We present 2 patients with allergic rhinitisAR that were deemed good candidates for AIT and explore current evidence for both subcutaneous immunotherapy and sublingual immunotherapy. The advantages and disadvantages of each method are discussed with the goal of providing a framework for the physician when deciding on AIT for their patients. In addition, we explore the use of AIT in patients with asthma and atopic dermatitis as potential patient populations that may benefit from the treatment. We use the discussion to provide recommendations regarding which method of AIT is best suited for both our patients. PMID: 3101...
Source: The American Journal of the Medical Sciences - April 25, 2019 Category: General Medicine Authors: Chaaban MR, Mansi A, Tripple JW, Wise SK Tags: Am J Med Sci Source Type: research

Transmission Electron Microscopy in Severe Pneumonia: Back to the Future?
PMID: 30904043 [PubMed - in process] (Source: The American Journal of the Medical Sciences)
Source: The American Journal of the Medical Sciences - March 26, 2019 Category: General Medicine Authors: Jalil B, Fraig M Tags: Am J Med Sci Source Type: research

Impact of Cirrhosis on Pneumonia-Related Outcomes in Hospitalized Older Veterans.
CONCLUSIONS: We found an association between cirrhosis and 90-day mortality and rehospitalization in older patients with pneumonia. We suggest that physicians should carefully monitor patients with cirrhosis who develop pneumonia. PMID: 30904044 [PubMed - in process] (Source: The American Journal of the Medical Sciences)
Source: The American Journal of the Medical Sciences - March 26, 2019 Category: General Medicine Authors: Boivin Z, Perez MF, Atuegwu NC, Anzueto A, Mortensen EM Tags: Am J Med Sci Source Type: research

CXCR4 and CCR7 Expression in Primary Nodal Diffuse Large B-Cell Lymphoma-A Clinical and Immunohistochemical Study.
CONCLUSIONS: There is a positive correlation between CXCR4 overexpression and BM involvement. CXCR4 and CCR7 overexpression is associated with poorer overall survival, especially in CXCR4 and CCR7 copositive patients. CXCR4, CCR7, Ki-67 index, and MYC were independent prognostic factors for DLBCL. Blocking CXCR4 and/or CCR7 can be a novel therapeutic strategy for DLBCL. PMID: 30904045 [PubMed - in process] (Source: The American Journal of the Medical Sciences)
Source: The American Journal of the Medical Sciences - March 26, 2019 Category: General Medicine Authors: Du H, Zhang L, Li G, Liu W, Tang W, Zhang H, Luan J, Gao L, Wang X Tags: Am J Med Sci Source Type: research

Soluble Vascular Cell Adhesion Molecule-1 Is Associated With Disease Activity in Adult-Onset Minimal Change Disease.
CONCLUSIONS: Patients with active MCD had increased levels of sVCAM-1 and sE-selectin. The correlation between sVCAM-1 and proteinuria, serum albumin and cholesterol and its decline during remission indicate that sVCAM-1 is associated with disease activity. PMID: 30904046 [PubMed - in process] (Source: The American Journal of the Medical Sciences)
Source: The American Journal of the Medical Sciences - March 26, 2019 Category: General Medicine Authors: Zhang Q, Zhang M, Sun C, Wang H, Tang T, Xia Y, Shao Q, Liu J, Jiang C Tags: Am J Med Sci Source Type: research

Primary Pulmonary Lymphoma: A Retrospective Analysis of 27 Cases in a Single Tertiary Hospital.
CONCLUSIONS: The clinical manifestations and imaging findings of PPL were nonspecific. The prognosis of MALT was better than other types of PPL. The International prognostic index can be used for predicting the prognosis of PPL. PMID: 30904047 [PubMed - in process] (Source: The American Journal of the Medical Sciences)
Source: The American Journal of the Medical Sciences - March 26, 2019 Category: General Medicine Authors: Zhang XY, Gu DM, Guo JJ, Su QQ, Chen YB Tags: Am J Med Sci Source Type: research

Farnesyl Pyrophosphate Synthase Blocker Ibandronate Reduces Thoracic Aortic Fibrosis in Diabetic Rats.
CONCLUSIONS: These findings provided evidence that FPPS is involved in thoracic aortic fibrosis in diabetic rats. Meanwhile, IBN could alleviate vascular remodeling in diabetic animals. PMID: 30904048 [PubMed - in process] (Source: The American Journal of the Medical Sciences)
Source: The American Journal of the Medical Sciences - March 26, 2019 Category: General Medicine Authors: Liu XW, Jin HF, Du CQ, Tang LJ Tags: Am J Med Sci Source Type: research

Likely Consequences of Medicare for All.
PMID: 30904049 [PubMed - in process] (Source: The American Journal of the Medical Sciences)
Source: The American Journal of the Medical Sciences - March 26, 2019 Category: General Medicine Authors: Berdine GG Tags: Am J Med Sci Source Type: research

Subglottic Stenosis in Granulomatosis With Polyangiitis.
PMID: 30904050 [PubMed - in process] (Source: The American Journal of the Medical Sciences)
Source: The American Journal of the Medical Sciences - March 26, 2019 Category: General Medicine Authors: Nagato T, Kishibe K, Harabuchi Y Tags: Am J Med Sci Source Type: research

The Birth of Angiotensin: An International Compromise.
Abstract Irvine Page in the United States and Eduardo Braun-Menéndez in Argentina led teams of investigators that studied the role of the kidney in blood pressure regulation. Contemporaneously in 1939, each team using different methods discovered and described a new substance now known as angiotensin. At the time of discovery, Page called it "angiotonin" and Braun-Menéndez called it "hipertensina," anglicized to "hypertensin." Over time, the importance of this substance in circulatory control, pathophysiology and pharmacology became indisputable and the need for a single...
Source: The American Journal of the Medical Sciences - February 27, 2019 Category: General Medicine Authors: Smulyan H, Villarreal D Tags: Am J Med Sci Source Type: research