Exosomes and Exosomal MicroRNAs in Age-Associated Stroke
Curr Vasc Pharmacol. 2021 Feb 8. doi: 10.2174/1570161119666210208202621. Online ahead of print.ABSTRACTAging has been considered to be the most important non-modifiable risk factor for stroke and death. Changes in circulation factors in the systemic environment, cellular senescence and artery hypertension during human ageing have been investigated. Exosomes are nanosize membrane vesicles that can regulate target cell functions via delivering their carried bioactive molecules (e.g. protein, mRNA, and microRNAs). In the central nervous system, exosomes and exosomal microRNAs play a critical role in regulating neurovascular f...
Source: Current Vascular Pharmacology - February 10, 2021 Category: Drugs & Pharmacology Authors: Xiang Wang Changmei HuangFu Xiudeng Zhu Jiehong Liu Xinqin Gong Qunwen Pan Xiaotang Ma Source Type: research

Exosomes and Exosomal MicroRNAs in Age-Associated Stroke
Curr Vasc Pharmacol. 2021 Feb 8. doi: 10.2174/1570161119666210208202621. Online ahead of print.ABSTRACTAging has been considered to be the most important non-modifiable risk factor for stroke and death. Changes in circulation factors in the systemic environment, cellular senescence and artery hypertension during human ageing have been investigated. Exosomes are nanosize membrane vesicles that can regulate target cell functions via delivering their carried bioactive molecules (e.g. protein, mRNA, and microRNAs). In the central nervous system, exosomes and exosomal microRNAs play a critical role in regulating neurovascular f...
Source: Current Vascular Pharmacology - February 10, 2021 Category: Drugs & Pharmacology Authors: Xiang Wang Changmei HuangFu Xiudeng Zhu Jiehong Liu Xinqin Gong Qunwen Pan Xiaotang Ma Source Type: research

Exosomes and Exosomal MicroRNAs in Age-Associated Stroke
Curr Vasc Pharmacol. 2021 Feb 8. doi: 10.2174/1570161119666210208202621. Online ahead of print.ABSTRACTAging has been considered to be the most important non-modifiable risk factor for stroke and death. Changes in circulation factors in the systemic environment, cellular senescence and artery hypertension during human ageing have been investigated. Exosomes are nanosize membrane vesicles that can regulate target cell functions via delivering their carried bioactive molecules (e.g. protein, mRNA, and microRNAs). In the central nervous system, exosomes and exosomal microRNAs play a critical role in regulating neurovascular f...
Source: Current Vascular Pharmacology - February 10, 2021 Category: Drugs & Pharmacology Authors: Xiang Wang Changmei HuangFu Xiudeng Zhu Jiehong Liu Xinqin Gong Qunwen Pan Xiaotang Ma Source Type: research

Exosomes and Exosomal MicroRNAs in Age-Associated Stroke.
Abstract Aging has been considered to be the most important non-modifiable risk factor for stroke and death. Changes in circulation factors in the systemic environment, cellular senescence and artery hypertension during human ageing have been investigated. Exosomes are nanosize membrane vesicles that can regulate target cell functions via delivering their carried bioactive molecules (e.g. protein, mRNA, and microRNAs). In the central nervous system, exosomes and exosomal microRNAs play a critical role in regulating neurovascular function, and are implicated in the initiation and progression of stroke. MicroRNAs ar...
Source: Current Vascular Pharmacology - February 8, 2021 Category: Drugs & Pharmacology Authors: Wang X, HuangFu C, Zhu X, Liu J, Gong X, Pan Q, Ma X Tags: Curr Vasc Pharmacol Source Type: research

Blood-brain barrier dysfunction and extension of time window for thrombolysis: a limitation not evaluated.
PMID: 33535958 [PubMed - as supplied by publisher] (Source: Current Vascular Pharmacology)
Source: Current Vascular Pharmacology - February 3, 2021 Category: Drugs & Pharmacology Authors: Siniscalchi A, Sztajzel R, Murphy S, De Sarro G, Gallelli L Tags: Curr Vasc Pharmacol Source Type: research

Pro-inflammatory Mediators and Oxidative Stress: Therapeutic Markers for Recurrent Angina Pectoris after Coronary Artery Stenting in Elderly Patients.
Abstract BACKGROUND: Pro-inflammatory mediators and oxidative stress are related to severity of angina pectoris in patients with coronary heart disease. OBJECTIVE: We evaluated the effects of pro-inflammatory mediators and oxidative stress on recurrent angina pectoris after coronary artery stenting in elderly patients. METHODS: We determined the expression levels of malondialdehyde (MDA), acrolein (ACR), tumour necrosis factor-α (TNF-α), toll-like receptor 4 (TLR4), superoxide dismutase 3 (SOD3), paraoxonase-1 (PON-1), stromal cell-derived factor-1α (SDF-1α) and endothelial progen...
Source: Current Vascular Pharmacology - January 29, 2021 Category: Drugs & Pharmacology Authors: Li X, Guo D, Zhou H, Hu Y, Fang X, Chen Y Tags: Curr Vasc Pharmacol Source Type: research

Outcomes of Anticoagulant Therapy with Low-Molecular-Weight Heparin (LMWH) and Warfarin for Thromboangiitis Obliterans (TAO).
Abstract BACKGROUND: Thromboangiitis obliterans (TAO) is a chronic, non-atherosclerotic, progressive inflammatory vascular disease affecting the small- and medium-size arteries and veins of the extremities. OBJECTIVE: To evaluate whether long-term anticoagulation with low-molecular-weight heparin (LMWH) and warfarin is beneficial for treating the inflammation and symptoms associated with TAO. METHODS: Patients with TAO who underwent anticoagulation as the mainstay of treatment were included in this prospective study. Rest pain relief and healing of trophic lesions (as the primary and secondary endpoint) ...
Source: Current Vascular Pharmacology - January 18, 2021 Category: Drugs & Pharmacology Authors: Gao J, Huang L, Wang J Tags: Curr Vasc Pharmacol Source Type: research

Improved lipid target level attainment in patients with peripheral artery disease.
Abstract BACKGROUND: Patients with peripheral artery disease (PAD) fall under the category of a very high cardiovascular risk. Although, consequent lipid lowering therapy (LLT) is advised, only sparse data on attained target level in PAD exists. OBJECTIVES: We aimed to analyse contemporary guideline recommendations for LLT in symptomatic PAD patients. METHODS: monocentric, prospective, observational study involving 200 symptomatic PAD patients. Guideline target level attainment and LLT were analysed between 2017 and 2019. RESULTS: Overall 78.5% of the patients were on statin therapy, mainly of high ...
Source: Current Vascular Pharmacology - January 11, 2021 Category: Drugs & Pharmacology Authors: Dopheide JF, Adam L, Wiedmer S, Kaspar M, Silbernagel G, Baumgartner I, Drexel H Tags: Curr Vasc Pharmacol Source Type: research

Emerging Cardiovascular Risk Factors and Specific Patient Populations at Increased Cardiovascular Risk.
PMID: 33413053 [PubMed - in process] (Source: Current Vascular Pharmacology)
Source: Current Vascular Pharmacology - January 9, 2021 Category: Drugs & Pharmacology Authors: Katsiki N, Doumas M Tags: Curr Vasc Pharmacol Source Type: research

Diabetes and Obesity in Pregnancy: From Patients to Molecular Mechanisms.
PMID: 33413056 [PubMed - in process] (Source: Current Vascular Pharmacology)
Source: Current Vascular Pharmacology - January 9, 2021 Category: Drugs & Pharmacology Authors: Sobrevia L Tags: Curr Vasc Pharmacol Source Type: research

Exploring the High Burden of Cardiovascular Disease Among Patients with End-Stage Renal Disease.
PMID: 33402078 [PubMed - in process] (Source: Current Vascular Pharmacology)
Source: Current Vascular Pharmacology - January 8, 2021 Category: Drugs & Pharmacology Authors: Liakopoulos V, Georgianos PI Tags: Curr Vasc Pharmacol Source Type: research

Statins and Non-Alcoholic Fatty Liver Disease Progression: Further Comments.
PMID: 33327917 [PubMed - as supplied by publisher] (Source: Current Vascular Pharmacology)
Source: Current Vascular Pharmacology - December 15, 2020 Category: Drugs & Pharmacology Authors: Athyros VG, Koumaras C, Sfikas G Tags: Curr Vasc Pharmacol Source Type: research

Adherence to treatment, arterial stiffness and cognitive function in irbesartan-treated newly diagnosed hypertensive patients.
Abstract OBJECTIVE: Non-adherence to antihypertensive agents leads to reduced blood pressure (BP) control. Data supporting the correlation of adherence with arterial stiffness (AS) are few. Furthermore, the causal relationship between AS and cognitive dysfunction (CO/DY) has not been clearly established. It is suggested that angiotensin II receptor blockers (ARBs) exhibit the lowest discontinuation rate among antihypertensive drugs. DESIGN AND METHODS: We followed up patients receiving monotherapy with irbesartan. CO/DY was assessed with Mini Mental State Examination (MΜSE) and other tests. RESULTS: P...
Source: Current Vascular Pharmacology - November 20, 2020 Category: Drugs & Pharmacology Authors: Kalaitzidis RG, Balafa O, Dounousi E, Stagikas D, Tsimihodimos V Tags: Curr Vasc Pharmacol Source Type: research

Pre- and post-conditioning of the heart: an overview of cardioprotective signaling pathways.
This article provides an overview of ischemic pre-, post-, remote, and pharmacological conditioning related to the heart. In addition, we reviewed the cardioprotective signaling pathways and therapeutic agents involved in the above-mentioned processes, aiming to provide a comprehensive evaluation of the advancements in the field. The advancements made over the last decades cannot be ignored and with the exponential growth in techniques and applications. The future of pre- and post-conditioning is promising. PMID: 33222675 [PubMed - as supplied by publisher] (Source: Current Vascular Pharmacology)
Source: Current Vascular Pharmacology - November 20, 2020 Category: Drugs & Pharmacology Authors: de Miranda DC, de Oliveira Faria G, Hermidorff MM, Dos Santos Silva FC, de Assis LVM, Isoldi MC Tags: Curr Vasc Pharmacol Source Type: research

Cardioprotective effects of natural products via the Nrf2 signaling path-way.
Abstract Due to its poor regenerative capacity, the heart is specifically vulnerable to xenobiotic-induced cardiotoxicity, myocardial ischaemia/reperfusion injury and other pathologies. Nuclear factor erythroid-2-related factor 2 (Nrf2) is consid-ered as an essential factor in protecting cardiomyocytes against oxidative stress resulting from free radicals and reactive ox-ygen species. It also serves as a key regulator of antioxidant enzyme expression via the antioxidant response element, a cis-regulatory element, which is found in the promoter region of several genes encoding detoxification enzymes and cytoprotec-...
Source: Current Vascular Pharmacology - November 3, 2020 Category: Drugs & Pharmacology Authors: Tavakoli R, Tabeshpour J, Asili J, Shakeri A, Sahebkar A Tags: Curr Vasc Pharmacol Source Type: research

Diabetic Cardiomyopathy: Clinical and Metabolic Approach.
CONCLUSION: Imaging procedures, especially myocardial strain with echocardiography and cardiac magnetic resonance are useful to identify the early signs of DCM. Research and studies regarding new treatment options are still "in progress". PMID: 33143612 [PubMed - as supplied by publisher] (Source: Current Vascular Pharmacology)
Source: Current Vascular Pharmacology - November 2, 2020 Category: Drugs & Pharmacology Authors: Djordjevic DB, Koracevic G, Djordjevic AD, Lovic DB Tags: Curr Vasc Pharmacol Source Type: research

Prevalence, diagnosis and treatment with 3 different statins of non-alcoholic fatty liver disease/non-alcoholic steatohepatitis in military personnel. Do genetics play a role?
Abstract BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) and its severe form, non-alcoholic steatohepatitis (NASH), are major health problems worldwide. Genetics may play a role in the pathogenesis of NAFLD/NASH. AIM: To investigate the prevalence of NAFLD/NASH in 5,400 military personnel and evaluate the effect of treatment with 3 statins on NAFLD/NASH using 2 non-invasive scores [NAFLD Activity Score (NAS); Fibrosis-4 score (FIB-4)]. METHODS: During the mandatory annual medical check-up, military personnel underwent a clinical and laboratory evaluation. Participants with NAFLD/NASH were randomise...
Source: Current Vascular Pharmacology - October 15, 2020 Category: Drugs & Pharmacology Authors: Sfikas G, Psallas M, Koumaras C, Imprialos K, Perdikakis E, Doumas M, Giouleme O, Karagiannis A, Athyros VG Tags: Curr Vasc Pharmacol Source Type: research

Editorial on Prevalence, Diagnosis and Treatment with 3 Different Statins of Non-Alcoholic Fatty Liver Disease/Non-Alcoholic Steatohepatitis in Military Personnel. Do Genetics Play a Role?
kov M PMID: 33032512 [PubMed - as supplied by publisher] (Source: Current Vascular Pharmacology)
Source: Current Vascular Pharmacology - October 8, 2020 Category: Drugs & Pharmacology Authors: Muzurović E, Smolović B, Vujošević S, Petakov M Tags: Curr Vasc Pharmacol Source Type: research

Cardiovascular risk and quality of life in autosomal dominant polycystic kidney disease patients in therapy with tolvaptan: A pilot study.
CONCLUSIONS: These preliminary results suggest that treatment with tolvaptan could improve early atherosclerosis and endothelial dysfunction markers and improve the mood in ADPKD patients (probably by the acting on endothelial cell and adipocyte V2 receptors). PMID: 32957887 [PubMed - as supplied by publisher] (Source: Current Vascular Pharmacology)
Source: Current Vascular Pharmacology - September 16, 2020 Category: Drugs & Pharmacology Authors: Lai S, Mangiulli M, Perrotta AM, Gigante A, Napoleoni L, Cipolloni E, Mitterhofer AP, Gasperini ML, Muscaritoli M, Cianci R, Giovannetti A, Falco F, Mastroluca D, Mazzaferro S Tags: Curr Vasc Pharmacol Source Type: research

Role of nicotinic acetylcholine receptors in cardiovascular physiology and pathophysiology: current trends and perspectives.
Abstract Nicotinic acetylcholine receptors (nAChRs) comprise a large family of ligand-gated ion channels that have a broad distribution in neurons and non-neuronal cells throughout the body. Native nAChRs, activated by acetylcholine (ACh) endogenously, are involved in a variety of physiological and pathophysiological processes. They regulate processes necessary for network operations through neurotransmitter release, cell excitability and neuronal integration. Emerging evidence suggests that nAChRs are capable of regulating cardiovascular (CV) functions in a cell type-specific manner, through the nervous system an...
Source: Current Vascular Pharmacology - September 15, 2020 Category: Drugs & Pharmacology Authors: Deng J, Jiang H Tags: Curr Vasc Pharmacol Source Type: research

Rationale and Design of the ACS-BP Study: Prognostic Value of In-Hospital Blood Pressure and Indices of Atherosclerosis in Acute Coronary Syndromes.
CONCLUSION: The study results should clarify the role of these non-invasive tools in secondary risk stratification of such patients. PMID: 32819248 [PubMed - as supplied by publisher] (Source: Current Vascular Pharmacology)
Source: Current Vascular Pharmacology - August 19, 2020 Category: Drugs & Pharmacology Authors: Koumelli A, Konstantinou K, Kasiakogias A, Dimitriadis K, Leontsinis I, Mantzouranis E, Tolis E, Fragkoulis C, Ntalakouras I, Thomopoulos C, Tousoulis D, Tsioufis C Tags: Curr Vasc Pharmacol Source Type: research

Efficacy and Safety of Antiplatelet Therapies in Symptomatic Peripheral Artery Disease: A Systematic Review and Network Meta-Analysis.
CONCLUSION: This updated network meta-analysis confirms that clopidogrel significantly decreases the risk of major adverse cardiovascular events compared with aspirin, without increasing bleeding risk. Clopidogrel should remain a mainstay of PAD treatment, at least in patients at higher bleeding risk. PMID: 32819249 [PubMed - as supplied by publisher] (Source: Current Vascular Pharmacology)
Source: Current Vascular Pharmacology - August 19, 2020 Category: Drugs & Pharmacology Authors: De Carlo M, Di Minno G, Sayre T, Fazeli MS, Siliman G, Cimminiello C Tags: Curr Vasc Pharmacol Source Type: research

PCSK9 Inhibitors and Ezetimibe Monotherapy in Patients Not Receiving Statins: A Meta-Analysis of Randomized Trials.
Abstract BACKGROUND: Statins are the mainstay of treatment for low-density lipoprotein cholesterol (LDL-C) lowering, however, some patients cannot tolerate statins because of adverse effects. Ezetimibe and proprotein convertase subtilisin/kexin type 9 inhibitors (PCSK9i) are alternative treatment options. The purpose of this meta-analysis is to compare LDL-C reduction with ezetimibe vs PCSK9i in patients not on statins. METHODS: PubMed and EMBASE were searched until 14 March 2020 for randomized clinical trials (RCTs) assessing the efficacy of ezetimibe vs PCSK9i in patients not on statins. The primary outcome...
Source: Current Vascular Pharmacology - August 5, 2020 Category: Drugs & Pharmacology Authors: Benhuri B, Ueyama H, Takagi H, Briasoulis A, Kuno T Tags: Curr Vasc Pharmacol Source Type: research

Cardio-Rheumatology: Two Collaborating Disciplines to Deal with the Enhanced Cardiovascular Risk in Autoimmune Rheumatic Diseases Part 2.
Abstract In Part 1 of this Thematic Issue entitled "Systemic Autoimmune Rheumatic Diseases and Cardiology", a panel of specialists and experts in cardiology, rheumatology, immunology and related fields discussed the cardiovascular complications of spondyloarthritides, rheumatoid arthritis, Sjogren's syndrome and vasculitides, as well as relevant cardiovascular issues related to non-biologic and biologic disease-modifying anti-rheumatic drugs (DMARDs), and provided their recommendations for prevention and management of these complications. In part 2 of this Thematic Issue, experts discuss the enhanced car...
Source: Current Vascular Pharmacology - July 20, 2020 Category: Drugs & Pharmacology Authors: Manolis AS, Tzioufas AG Tags: Curr Vasc Pharmacol Source Type: research

Obesity and gestational diabetes in pregnant care and clinical practice.
Abstract Obesity and Gestational Diabetes Mellitus (GDM) are the most frequent pathologies affecting mothers and offspring during pregnancy. Both conditions have shown a sustained increase in their prevalence in recent years, and they worsen the outcome of pregnancy and the long-term health of mothers. Obesity increases the risk of GDM and preeclampsia during pregnancy and elevates the risk of developing metabolic syndrome in later life. Offspring of obese mothers have an increased risk of obstetric morbidity and mortality and, consistent with the developmental origins of health and disease, a long term risk of ch...
Source: Current Vascular Pharmacology - June 27, 2020 Category: Drugs & Pharmacology Authors: Poblete JA, Olmos P Tags: Curr Vasc Pharmacol Source Type: research

The Innate Immune System And Cardiovascular Disease In Eskd: Monocytes And Natural Killer Cells.
Abstract Adverse innate immune responses have been implicated in several disease processes, including cardiovascular disease (CVD) and chronic kidney disease (CKD). The monocyte subsets natural killer (NK) cells and natural killer T (NKT) cells are involved in innate immunity. Monocytes subsets are key in atherogenesis and the inflammatory cascade occurring in heart failure. Upregulated activity and counts of pro-inflammatory CD16+ monocyte subsets are associated with clinical indices of atherosclerosis, heart failure syndromes and CKD. Advanced CKD is a complex state of persistent systemic inflammation characteri...
Source: Current Vascular Pharmacology - June 26, 2020 Category: Drugs & Pharmacology Authors: Dounousi E, Duni A, Naka KK, Vartholomatos G, Zoccali C Tags: Curr Vasc Pharmacol Source Type: research

Effects of Maternal Obesity and Gestational Diabetes Mellitus on the Placenta: Current Knowledge and Targets for Therapeutic Interventions.
Abstract Obesity and gestational diabetes mellitus (GDM) are becoming more common among pregnant women worldwide and are individually associated with a number of placenta-mediated obstetric complications, including preeclampsia, macrosomia, intrauterine growth restriction and stillbirth. The placenta serves several functions throughout pregnancy and is the main exchange site for the transfer of nutrients and gas from mother to fetus. In pregnancies complicated by maternal obesity or GDM, the placenta is exposed to environmental changes, such as increased inflammation and oxidative stress, dyslipidemia, and altered...
Source: Current Vascular Pharmacology - June 15, 2020 Category: Drugs & Pharmacology Authors: Bedell S, Hutson J, de Vrijer B, Eastabrook G Tags: Curr Vasc Pharmacol Source Type: research

Efficacy and Safety of Evolocumab in Reducing Low Density Lipoprotein Cholesterol Levels in Chinese Patients with Non-ST-segment Elevation Acute Coronary Syndrome.
Abstract AIMS: To explore early intensive lipid-lowering therapy in patients with non-ST-segment elevation acute coronary syndrome (NSTE-ACS). BACKGROUND: Lowering low-density lipoprotein cholesterol (LDL-C) levels can reduce cardiovascular morbidity and mortality in patients with atherosclerotic cardiovascular disease. Due to many reasons, the need for early intensive lipid-lowering therapy is far from being met in Chinese NSTE-ACS patients at high-risk of recurrent ischaemic events. OBJECTIVE: To evaluate the feasibility, safety and efficacy of starting evolocumab in hospital to lower LDL-C levels in C...
Source: Current Vascular Pharmacology - June 15, 2020 Category: Drugs & Pharmacology Authors: Xu X, Chai M, Cheng Y, Peng P, Liu X, Yan Z, Guo Y, Zhao Y, Zhou Y Tags: Curr Vasc Pharmacol Source Type: research

Herbal Medicine for Slowing Aging and Cardiovascular Risk: Mechanisms and Safety.
PMID: 32519621 [PubMed - in process] (Source: Current Vascular Pharmacology)
Source: Current Vascular Pharmacology - June 12, 2020 Category: Drugs & Pharmacology Authors: Liu Y, Liu Y Tags: Curr Vasc Pharmacol Source Type: research

Response to Letter to the Editor by Briana and Malamitsi-Puchner: Effects of Pregnancy-induced Insulin Resistance on the Fetus and the Future Development of Metabolic Diseases in Adulthood.
ez CM PMID: 32519622 [PubMed - in process] (Source: Current Vascular Pharmacology)
Source: Current Vascular Pharmacology - June 12, 2020 Category: Drugs & Pharmacology Authors: Mate A, Blanca AJ, Salsoso R, Toledo F, Stiefel P, Sobrevia L, Vázquez CM Tags: Curr Vasc Pharmacol Source Type: research

Paget's Disease of Bone and Cardiovascular Risk: a Pilot Study.
CONCLUSION: These findings, although limited by the small study population, represent an original observation that deserves further study. The higher arterial stiffness in PDB could be related to the increased bone turnover or to the high levels of oxidative stress that characterize this population. PMID: 32516100 [PubMed - as supplied by publisher] (Source: Current Vascular Pharmacology)
Source: Current Vascular Pharmacology - June 8, 2020 Category: Drugs & Pharmacology Authors: Gaudio A, Zanoli L, Xourafa A, Rapisarda R, Catalano A, Signorelli SS, Castellino P Tags: Curr Vasc Pharmacol Source Type: research

Stromal Cell-Derived Factor (SDF) 2 and the Endoplasmic Reticulum Stress Response of Trophoblast Cells in Gestational Diabetes Mellitus and in vitro Hyperglycaemic Condition.
CONCLUSION: Our findings extend the understanding of ER stress and SDF2 expression in placentae exposed to hyperglycaemia, highlighting the relevance of insulin in reducing the levels of ER stress factors in placental cells. Understanding the effect of ER stress partners such as SDF2 on signalling pathways involved in gestation, complicated by hyperglycaemia, is pivotal for basic biomedical research and may lead to new therapeutic possibilities. PMID: 32504504 [PubMed - as supplied by publisher] (Source: Current Vascular Pharmacology)
Source: Current Vascular Pharmacology - June 5, 2020 Category: Drugs & Pharmacology Authors: Lorenzon AR, Moreli JB, de Macedo Melo R, Namba FY, Staff AC, Yung HW, Burton GJ, Bevilacqua E Tags: Curr Vasc Pharmacol Source Type: research

Evaluation of Therapeutic Agents Targeting the Pathogenesis of Coronary Artery Spasm: A Mini Review.
This article discusses the pathophysiological mechanisms as well as downstream molecular pathways of CAS, with a focus on potential therapeutic targets. PMID: 32493195 [PubMed - as supplied by publisher] (Source: Current Vascular Pharmacology)
Source: Current Vascular Pharmacology - June 2, 2020 Category: Drugs & Pharmacology Authors: Zhao X, Tian J, Ye Z, Xu M, Song X, Huang R Tags: Curr Vasc Pharmacol Source Type: research

Inflammasomes in the pathophysiology of maternal obesity: Potential therapeutic targets to reduce long-term adverse health outcomes in the mother and offspring.
Abstract Over the past 20 years, the prevalence of obesity has risen dramatically worldwide, with an increase in occurrence among women in their reproductive age. Obesity during pregnancy is associated with significantly increased maternal and fetal morbidity and mortality. In addition to the short-term adverse health outcomes, both mother and the child are prone to develop cardiovascular, metabolic and neurological disorders. Although associations between obesity during pregnancy and adverse maternal-fetal health outcomes are clear, the complex molecular mechanisms underlying maternal obesity remain largely unkno...
Source: Current Vascular Pharmacology - June 2, 2020 Category: Drugs & Pharmacology Authors: Murthi P, Rajaraman G Tags: Curr Vasc Pharmacol Source Type: research

Effects of Gentiana lutea root on vascular diseases.
CONCLUSION: Gentiana species and their constituents affect many different factors related to vascular disease development and progression. Therefore, Gentiana-based therapeutics represent potentially useful drugs for the management of vascular diseases. PMID: 32469702 [PubMed - as supplied by publisher] (Source: Current Vascular Pharmacology)
Source: Current Vascular Pharmacology - May 28, 2020 Category: Drugs & Pharmacology Authors: Joksic G, Radak D, Sudar-Milovanovic E, Obradovic M, Radovanovic J, Isenovic ER Tags: Curr Vasc Pharmacol Source Type: research

Investigating the link between psoriasis and cardiovascular disease: current evidence, therapeutic implications and perspectives.
Abstract Psoriasis; a chronic inflammatory disease is characterized by symmetric hyperkeratotic plaques affecting any part of the body. Psoriasis is nowadays considered as a systemic inflammation linked with several comorbidities as metabolic syndrome, depression, anxiety and increased prevalence of cardiovascular (CV) disease. The hypothesis that psoriasis is an independent CV risk factor leading to atherosclerosis via inflammation. is now widely accepted. Deciphering the underlying mechanisms interconnecting psoriasis and CV disease may have significant implications on treatment decisions. Accumulating evidence ...
Source: Current Vascular Pharmacology - May 22, 2020 Category: Drugs & Pharmacology Authors: Kapniari E, Papadimitriou P, Dalamaga M, Makavos G, Piaserico S, Egeberg A, Ikonomidis I, Papadavid E Tags: Curr Vasc Pharmacol Source Type: research

Compelling indications should be listed for individual beta-blockers (due to diversity), not for the whole class.
Conclusions BBs differ within the class in so many ways that it is not only logical but also practical for real-life clinical practice that experts in the field make a list of the compelling indications for individual BBs. Time has come to incorporate our knowledge about BBs into a new approach of presenting these useful and very individual drugs. PMID: 32418526 [PubMed - as supplied by publisher] (Source: Current Vascular Pharmacology)
Source: Current Vascular Pharmacology - May 17, 2020 Category: Drugs & Pharmacology Authors: Koracevic G, Micic S, Stojanovic M, Lovic D, Simic D, Colic M, Koracevic M, Stojkovic A, Paunovic M Tags: Curr Vasc Pharmacol Source Type: research

Cardio-Rheumatology: Cardiovascular Complications in Systemic Autoimmune Rheumatic Diseases / Is Inflammation the Common Link and Target?
Abstract In the current Thematic Issue of Current Vascular Pharmacology (CVP), entitled "Systemic Autoimmune Rheumatic Diseases and Cardiology", presented in two parts, Part 1 and Part 2, review articles are included from specialists in cardiology, rheumatology, immunology and related fields. These reviews discuss the cardiovascular complications of the main systemic autoimmune rheumatic diseases (ARDs). For example, the underlying pathogenetic mechanisms, the role of cardiovascular imaging and recommendations for prevention and management. These articles place inflammation as the key process, linking ca...
Source: Current Vascular Pharmacology - May 13, 2020 Category: Drugs & Pharmacology Authors: Manolis AS, Tzioufas AG Tags: Curr Vasc Pharmacol Source Type: research

Effects of Maternal Obesity On Placental Phenotype.
Abstract The incidence of obesity is rising rapidly worldwide with the consequence that more women are entering pregnancy overweight or obese. This leads to an increased incidence of clinical complications during pregnancy and of poor obstetric outcomes. The offspring of obese pregnancies are often macrosomic at birth although there is also a subset of the progeny that are growth restricted at term. Maternal obesity during pregnancy is also associated with cardiovascular, metabolic and endocrine dysfunction in the offspring later in life. As the interface between the mother and fetus, the placenta has a central ro...
Source: Current Vascular Pharmacology - May 12, 2020 Category: Drugs & Pharmacology Authors: Fowden A, Camm E, Sferruzzi-Perri A Tags: Curr Vasc Pharmacol Source Type: research

Prime Time for Lower Extremity Artery Disease.
PMID: 32340598 [PubMed - in process] (Source: Current Vascular Pharmacology)
Source: Current Vascular Pharmacology - April 30, 2020 Category: Drugs & Pharmacology Authors: De Carlo M Tags: Curr Vasc Pharmacol Source Type: research

Abnormal Peri-organ-Intra-organ Fat (APIFat) and Rheumatoid Arthritis: An Under-investigated Link for Increased Cardiovascular Risk?
PMID: 32340599 [PubMed - in process] (Source: Current Vascular Pharmacology)
Source: Current Vascular Pharmacology - April 30, 2020 Category: Drugs & Pharmacology Authors: Katsiki N, Mikhailidis DP, Mantzoros C Tags: Curr Vasc Pharmacol Source Type: research

Endothelial dysfunction and inflammatory markers of vascular disease.
Abstract Vascular diseases are the main reason for morbidity and mortality worldwide. As we known, the earlier phase of vascular diseases is endothelial dysfunction in humans. The endothelial tissues play an important role in inflammation, coagulation, and angiogenesis, via the organizing of ligand-receptor associations and the various mediators' secretion. We can use many inflammatory non-invasive tests (flow-mediated dilatation, epicedial fat thickness, carotid-intima media thickness, arterial stiffness and ankle-brachial index) for assessing the endothelial function. In addition, many biomarkers (ischemia modif...
Source: Current Vascular Pharmacology - April 20, 2020 Category: Drugs & Pharmacology Authors: Balta S Tags: Curr Vasc Pharmacol Source Type: research

New insights into the role of FGF-23 and Klotho in cardiovascular disease in chronic kidney disease patients.
Abstract Alterations of fibroblast growth factor 23 (FGF-23) and Klotho levels are considered to be the earliest biochemical abnormality of chronic kidney disease - mineral and bone disease (CKD-MBD) syndrome. Moreover, emerging data suggests that the dysregulated FGF-23 and Klotho axis has many effects on the cardiovascular (CV) system and contributes significantly to the increased CV morbidity and mortality rates of CKD patients. This review examines recent evidence on the role of FGF-23 and Klotho in the development and progression of CV complications of uremia namely cardiac hypertrophy, uremic cardiomyopathy ...
Source: Current Vascular Pharmacology - April 18, 2020 Category: Drugs & Pharmacology Authors: Memmos E, Papagianni A Tags: Curr Vasc Pharmacol Source Type: research

The Significance of Renal Function in Response to Cardiac Resynchronisation Therapy - The Piece of a Much Larger Puzzle.
CONCLUSIONS: Predictive value of GFR CKD-EPI and creatinine concentration for a positive response to CRT were found relevant. PMID: 32286948 [PubMed - as supplied by publisher] (Source: Current Vascular Pharmacology)
Source: Current Vascular Pharmacology - April 12, 2020 Category: Drugs & Pharmacology Authors: Dębska-Kozłowska A, Warchoł I, Książczyk M, Lubiński A Tags: Curr Vasc Pharmacol Source Type: research

Erectile dysfunction as a cardiovascular risk factor: time to step up?.
CONCLUSION: Accumulating evidence supports a strong predictive role of ED for CV events. Early identification of ED could allow for the optimal management of these patients to reduce the risk for a CV event to occur. PMID: 32286949 [PubMed - as supplied by publisher] (Source: Current Vascular Pharmacology)
Source: Current Vascular Pharmacology - April 12, 2020 Category: Drugs & Pharmacology Authors: Imprialos K, Koutsampasopoulos K, Manolis A, Doumas M Tags: Curr Vasc Pharmacol Source Type: research

Cardiovascular disease in Juvenile Idiopathic Arthritis.
Abstract Juvenile idiopathic arthritis (JIA), is a term used to describe a group of inflammatory disorders beginning before the age of 16 years. Although for the majority of children remission is achieved early, those with systemic or polyarticular form of the disease may present persistent symptoms in adulthood. Considering that there is overlap in the pathogenesis of JIA with adult rheumatic diseases, concerns have been raised as to whether JIA patients could be at increased cardiovascular (CV) risk in the long-term. In this review, we summarize evidence for CV involvement in JIA and present data on CV risk fact...
Source: Current Vascular Pharmacology - April 7, 2020 Category: Drugs & Pharmacology Authors: Arsenaki E, Georgakopoulos P, Mitropoulou P, Koutli E, Thomas K, Charakida M, Georgiopoulos G Tags: Curr Vasc Pharmacol Source Type: research

Pulse wave velocity assessment for cardiovascular risk prognostication in ESKD: weighing recent evidence.
CONCLUSION: Despite the strong pathophysiological relevance of arterial stiffness as a mediator of CV disease in ESKD, the assessment of aortic PWV for CV risk stratification in this population appears to be of limited value. Whether aortic PWV assessment is valuable in guiding CV risk factor management and whether such a therapeutic approach is translated into improvement in clinical outcomes is an issue of clinical relevance that warrants investigation in properly-designed randomized trials. PMID: 32242783 [PubMed - as supplied by publisher] (Source: Current Vascular Pharmacology)
Source: Current Vascular Pharmacology - April 2, 2020 Category: Drugs & Pharmacology Authors: Georgianos PI, Vaios V, Eleftheriadis T, Zebekakis PE, Liakopoulos V Tags: Curr Vasc Pharmacol Source Type: research

Coronary Calcium Risk Score and Cardiovascular Risk.
Abstract The association between presence of coronary artery calcium (CAC) and risk of coronary artery disease (CAD) has been appreciated for decades. In this review, we critically appraise the role of CAC based on computerized tomography in contemporary risk stratification. Available evidence suggests that measurement of CAC is a useful modality in many patients for more precise risk stratification and prognostic determination. Whether newer CAC score incorporating extra coronary calcification, will add incremental value, especially for stroke and other non-coronary vascular outcomes needs prospective study. ...
Source: Current Vascular Pharmacology - April 2, 2020 Category: Drugs & Pharmacology Authors: Lehker A, Mukherjee D Tags: Curr Vasc Pharmacol Source Type: research

Cardiovascular Benefits of Extended-Time Nocturnal Hemodialysis.
Abstract Hemodialysis (HD) remains the most utilized treatment for End Stage Kidney Disease (ESKD) globally, mainly as conventional HD administered in 4 h sessions thrice weekly. Despite advances in HD delivery, patients with ESKD carry a heavy cardiovascular morbidity and mortality burden. This is associated with cardiac remodeling, left ventricular hypertrophy (LVH), myocardial stunning, hypertension, decreased heart rate variability, sleep apnea, coronary calcification and endothelial dysfunction. Therefore, intensive HD regimens closer to renal physiology were developed. They include longer, more frequent dial...
Source: Current Vascular Pharmacology - March 31, 2020 Category: Drugs & Pharmacology Authors: Roumeliotis A, Roumeliotis S, Chan C, Pierratos A Tags: Curr Vasc Pharmacol Source Type: research

Lifestyle, maternal nutrition and healthy pregnancy.
te;zquez CM Abstract Healthy lifestyle habits spanning from preconception to postpartum are considered as a major safeguard for achieving successful pregnancies and for prevention of gestational diseases. Among preconception priorities established by the World Health Organization (WHO) are healthy diet and nutrition, weight management, physical activity, planned pregnancy and physical, mental and psychosocial health. Most studies covering the topic of healthy pregnancies focus on maternal diet because obesity increases the risks for adverse perinatal outcomes, including gestational diabetes mellitus, large for ges...
Source: Current Vascular Pharmacology - March 31, 2020 Category: Drugs & Pharmacology Authors: Mate A, Reyes-Goya C, Santana-Garrido Á, Vázquez CM Tags: Curr Vasc Pharmacol Source Type: research