Disentangling fetal insulin hypersecretion and insulin resistance

Trends Endocrinol Metab. 2024 May 1:S1043-2760(24)00091-2. doi: 10.1016/j.tem.2024.04.008. Online ahead of print.ABSTRACTDisentangling which of insulin hypersecretion and insulin resistance is upstream in obesity-related type 2 diabetes (T2D) is challenging. Here, we consider the dynamics of insulin secretion and action in the fetuses of mothers with diabetes. We argue that fetal insulin hypersecretion occurs first, with insulin resistance being an adaptive protective response.PMID:38697899 | DOI:10.1016/j.tem.2024.04.008
Source: Trends in Endocrinology and Metabolism: TEM - Category: Endocrinology Authors: Source Type: research