Trends in Endocrinology and Metabolism: TEM This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Harnessing beta cell regeneration biology for diabetes therapy
Trends Endocrinol Metab. 2024 Apr 20:S1043-2760(24)00082-1. doi: 10.1016/j.tem.2024.03.006. Online ahead of print.ABSTRACTThe pandemic scale of diabetes mellitus is alarming, its complications remain devastating, and current treatments still pose a major burden on those affected and on the healthcare system as a whole. As the disease emanates from the destruction or dysfunction of insulin-producing pancreatic β-cells, a real cure requires their restoration and protection. An attractive strategy is to regenerate β-cells directly within the pancreas; however, while several approaches for β-cell regeneration have been prop...
Source: Trends in Endocrinology and Metabolism: TEM - April 21, 2024 Category: Endocrinology Authors: Stephanie Bourgeois Sophie Coenen Laure Degroote Lien Willems Annelore Van Mulders Julie Pierreux Yves Heremans Nico De Leu Willem Staels Source Type: research

Pediatric thyroid side effects of immune checkpoint inhibitors
Trends Endocrinol Metab. 2024 Apr 17:S1043-2760(24)00085-7. doi: 10.1016/j.tem.2024.04.002. Online ahead of print.ABSTRACTImmune checkpoint inhibitors (ICIs) are associated with multiple endocrine side effects, including thyroid disfunctions. In addition, the efficacy and safety profiles of ICIs in the pediatric population need clarification. Here, we discuss the main evidence regarding the efficacy and thyroid toxicities of ICIs in children.PMID:38637222 | DOI:10.1016/j.tem.2024.04.002 (Source: Trends in Endocrinology and Metabolism: TEM)
Source: Trends in Endocrinology and Metabolism: TEM - April 18, 2024 Category: Endocrinology Authors: Cesare Morgante Alessandra Fierabracci Armando Grossi Source Type: research

Opportunities and challenges in phage therapy for cardiometabolic diseases
Trends Endocrinol Metab. 2024 Apr 17:S1043-2760(24)00083-3. doi: 10.1016/j.tem.2024.03.007. Online ahead of print.ABSTRACTThe worldwide prevalence of cardiometabolic diseases (CMD) is increasing, and emerging evidence implicates the gut microbiota in this multifactorial disease development. Bacteriophages (phages) are viruses that selectively target a bacterial host; thus, phage therapy offers a precise means of modulating the gut microbiota, limiting collateral damage on the ecosystem. Several studies demonstrate the potential of phages in human disease, including alcoholic and steatotic liver disease. In this opinion art...
Source: Trends in Endocrinology and Metabolism: TEM - April 18, 2024 Category: Endocrinology Authors: Koen Wortelboer Hilde Herrema Source Type: research

Effects of APOE4 on omega-3 brain metabolism across the lifespan
Trends Endocrinol Metab. 2024 Apr 11:S1043-2760(24)00065-1. doi: 10.1016/j.tem.2024.03.003. Online ahead of print.ABSTRACTOmega-3 (n-3) polyunsaturated fatty acids (PUFAs), such as docosahexaenoic acid (DHA), have important roles in human nutrition and brain health by promoting neuronal functions, maintaining inflammatory homeostasis, and providing structural integrity. As Alzheimer's disease (AD) pathology progresses, DHA metabolism in the brain becomes dysregulated, the timing and extent of which may be influenced by the apolipoprotein E ε4 (APOE4) allele. Here, we discuss how maintaining adequate DHA intake early in li...
Source: Trends in Endocrinology and Metabolism: TEM - April 12, 2024 Category: Endocrinology Authors: Brandon Ebright Marlon V Duro Kai Chen Stan Louie Hussein N Yassine Source Type: research

Selenium, diabetes, and their intricate sex-specific relationship
Trends Endocrinol Metab. 2024 Apr 10:S1043-2760(24)00066-3. doi: 10.1016/j.tem.2024.03.004. Online ahead of print.ABSTRACTSelenium (Se) is an essential trace element, which is inserted as selenocysteine (Sec) into selenoproteins during biosynthesis, orchestrating their expression and activity. Se is associated with both beneficial and detrimental health effects; deficient supply or uncontrolled supplementation raises concerns. In particular, Se was associated with an increased incidence of type 2 diabetes (T2D) in a secondary analysis of a randomized controlled trial (RCT). In this review, we discuss the intricate relation...
Source: Trends in Endocrinology and Metabolism: TEM - April 10, 2024 Category: Endocrinology Authors: Kamil Demircan Thilo Samson Chillon Jeyoung Bang Vadim N Gladyshev Lutz Schomburg Source Type: research

Ironing out obesity
Trends Endocrinol Metab. 2024 Apr 9:S1043-2760(24)00084-5. doi: 10.1016/j.tem.2024.04.001. Online ahead of print.ABSTRACTObesity is associated with dysfunctions in hypothalamic neurons that regulate metabolism, including agouti-related protein (AgRP)-expressing neurons. In a recent article, Zhang et al. demonstrated that either diet- or genetically induced obesity promoted iron accumulation specifically in AgRP neurons. Preventing iron overload in AgRP neurons mitigated diet-induced obesity and related comorbidities in male mice.PMID:38599900 | DOI:10.1016/j.tem.2024.04.001 (Source: Trends in Endocrinology and Metabolism: TEM)
Source: Trends in Endocrinology and Metabolism: TEM - April 10, 2024 Category: Endocrinology Authors: Gabriel O de Souza Willian O Dos Santos Jose Donato Source Type: research

Mitochondrial morphology, distribution and activity during oocyte development
Trends Endocrinol Metab. 2024 Apr 9:S1043-2760(24)00064-X. doi: 10.1016/j.tem.2024.03.002. Online ahead of print.ABSTRACTMitochondria have a crucial role in cellular function and exhibit remarkable plasticity, adjusting both their structure and activity to meet the changing energy demands of a cell. Oocytes, female germ cells that become eggs, undergo unique transformations: the extended dormancy period, followed by substantial increase in cell size and subsequent maturation involving the segregation of genetic material for the next generation, present distinct metabolic challenges necessitating varied mitochondrial adapta...
Source: Trends in Endocrinology and Metabolism: TEM - April 10, 2024 Category: Endocrinology Authors: Devesh Bahety Elvan B öke Aida Rodr íguez-Nuevo Source Type: research

Is MASLD lost in translation in mice?
Trends Endocrinol Metab. 2024 Apr 9:S1043-2760(24)00080-8. doi: 10.1016/j.tem.2024.03.005. Online ahead of print.ABSTRACTLack of preclinical model translation is often blamed for failed drug development. Here we discuss mouse models within the context of human steatotic liver disease (SLD). Variables such as aging and non-food hepatic stressors are often ignored but could explain challenges in reproducing the human disease in a laboratory.PMID:38599902 | DOI:10.1016/j.tem.2024.03.005 (Source: Trends in Endocrinology and Metabolism: TEM)
Source: Trends in Endocrinology and Metabolism: TEM - April 10, 2024 Category: Endocrinology Authors: Aysim Gunes Jennifer L Estall Source Type: research