More trials for the unhappy hypothyroid patient on thyroxine: a clinician's perspective
Trends Endocrinol Metab. 2022 May 23:S1043-2760(22)00083-2. doi: 10.1016/j.tem.2022.04.010. Online ahead of print.ABSTRACTFurther clinical trials are proposed for the 5-15% of hypothyroid patients who are dissatisfied with thyroxine (T4) monotherapy. Those responding to combination therapy [T4 plus triiodothyronine (T3)] will show suggestive biochemistry and abnormal reflexes. Those with Hashimoto's disease and very high anti-thyroid peroxidase (anti-TPO) thyroid antibody levels may benefit from total thyroidectomy. The remainder have negative clinical and laboratory findings and require supportive management.PMID:35618561...
Source: Trends in Endocrinology and Metabolism: TEM - May 26, 2022 Category: Endocrinology Authors: Timothy A Welborn Source Type: research

Neurological aspects of SARS-CoV-2 infection: lipoproteins and exosomes as Trojan horses
Trends Endocrinol Metab. 2022 May 2:S1043-2760(22)00084-4. doi: 10.1016/j.tem.2022.04.011. Online ahead of print.ABSTRACTSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) primarily targets lipid-producing cells for viral tropism. In this review, we connect systemic lipid couriers, particularly high-density lipoproteins (HDLs) and exosomes, with the neurological facets of SARS-CoV-2 infection. We discuss how SARS-CoV-2 preferentially targets lipid-secreting cells and usurps host cell lipid metabolism for efficient replication and systemic spreading. Besides providing natural veils for viral materials against host...
Source: Trends in Endocrinology and Metabolism: TEM - May 25, 2022 Category: Endocrinology Authors: Sin Man Lam Xun Huang Guanghou Shui Source Type: research

Shifting metabolism to increase lifespan
Trends Endocrinol Metab. 2022 May 18:S1043-2760(22)00087-X. doi: 10.1016/j.tem.2022.05.001. Online ahead of print.ABSTRACTLionaki et al. report that reducing mitochondrial protein import increases Caenorhabditis elegans lifespan, through a metabolic shift that enhances the conversion of glucose into serine. Here, I discuss the promise held by these findings in the framework of therapeutic approaches to metabolic and neurodegenerative diseases.PMID:35597712 | DOI:10.1016/j.tem.2022.05.001 (Source: Trends in Endocrinology and Metabolism: TEM)
Source: Trends in Endocrinology and Metabolism: TEM - May 21, 2022 Category: Endocrinology Authors: Jo ão Pessoa Source Type: research

Shifting metabolism to increase lifespan
Trends Endocrinol Metab. 2022 May 18:S1043-2760(22)00087-X. doi: 10.1016/j.tem.2022.05.001. Online ahead of print.ABSTRACTLionaki et al. report that reducing mitochondrial protein import increases Caenorhabditis elegans lifespan, through a metabolic shift that enhances the conversion of glucose into serine. Here, I discuss the promise held by these findings in the framework of therapeutic approaches to metabolic and neurodegenerative diseases.PMID:35597712 | DOI:10.1016/j.tem.2022.05.001 (Source: Trends in Endocrinology and Metabolism: TEM)
Source: Trends in Endocrinology and Metabolism: TEM - May 21, 2022 Category: Endocrinology Authors: Jo ão Pessoa Source Type: research

Shifting metabolism to increase lifespan
Trends Endocrinol Metab. 2022 May 18:S1043-2760(22)00087-X. doi: 10.1016/j.tem.2022.05.001. Online ahead of print.ABSTRACTLionaki et al. report that reducing mitochondrial protein import increases Caenorhabditis elegans lifespan, through a metabolic shift that enhances the conversion of glucose into serine. Here, I discuss the promise held by these findings in the framework of therapeutic approaches to metabolic and neurodegenerative diseases.PMID:35597712 | DOI:10.1016/j.tem.2022.05.001 (Source: Trends in Endocrinology and Metabolism: TEM)
Source: Trends in Endocrinology and Metabolism: TEM - May 21, 2022 Category: Endocrinology Authors: Jo ão Pessoa Source Type: research

Shifting metabolism to increase lifespan
Trends Endocrinol Metab. 2022 May 18:S1043-2760(22)00087-X. doi: 10.1016/j.tem.2022.05.001. Online ahead of print.ABSTRACTLionaki et al. report that reducing mitochondrial protein import increases Caenorhabditis elegans lifespan, through a metabolic shift that enhances the conversion of glucose into serine. Here, I discuss the promise held by these findings in the framework of therapeutic approaches to metabolic and neurodegenerative diseases.PMID:35597712 | DOI:10.1016/j.tem.2022.05.001 (Source: Trends in Endocrinology and Metabolism: TEM)
Source: Trends in Endocrinology and Metabolism: TEM - May 21, 2022 Category: Endocrinology Authors: Jo ão Pessoa Source Type: research

The gut microbiota: stable bioreactor of variable composition?
Trends Endocrinol Metab. 2022 May 16:S1043-2760(22)00062-5. doi: 10.1016/j.tem.2022.04.005. Online ahead of print.ABSTRACTThe gut microbiota plays a crucial role in host health, providing energy and vitamins from food undigested by the gut enzymes of the host. Bacterial metabolites, such as short-chain fatty acids (SCFAs), are essentially metabolized by the gut mucosa. The importance to metabolic health of gut microbiota composition versus function is discussed.PMID:35584972 | DOI:10.1016/j.tem.2022.04.005 (Source: Trends in Endocrinology and Metabolism: TEM)
Source: Trends in Endocrinology and Metabolism: TEM - May 18, 2022 Category: Endocrinology Authors: Gilles Mithieux Source Type: research

The gut microbiota: stable bioreactor of variable composition?
Trends Endocrinol Metab. 2022 May 16:S1043-2760(22)00062-5. doi: 10.1016/j.tem.2022.04.005. Online ahead of print.ABSTRACTThe gut microbiota plays a crucial role in host health, providing energy and vitamins from food undigested by the gut enzymes of the host. Bacterial metabolites, such as short-chain fatty acids (SCFAs), are essentially metabolized by the gut mucosa. The importance to metabolic health of gut microbiota composition versus function is discussed.PMID:35584972 | DOI:10.1016/j.tem.2022.04.005 (Source: Trends in Endocrinology and Metabolism: TEM)
Source: Trends in Endocrinology and Metabolism: TEM - May 18, 2022 Category: Endocrinology Authors: Gilles Mithieux Source Type: research

The gut microbiota: stable bioreactor of variable composition?
Trends Endocrinol Metab. 2022 May 16:S1043-2760(22)00062-5. doi: 10.1016/j.tem.2022.04.005. Online ahead of print.ABSTRACTThe gut microbiota plays a crucial role in host health, providing energy and vitamins from food undigested by the gut enzymes of the host. Bacterial metabolites, such as short-chain fatty acids (SCFAs), are essentially metabolized by the gut mucosa. The importance to metabolic health of gut microbiota composition versus function is discussed.PMID:35584972 | DOI:10.1016/j.tem.2022.04.005 (Source: Trends in Endocrinology and Metabolism: TEM)
Source: Trends in Endocrinology and Metabolism: TEM - May 18, 2022 Category: Endocrinology Authors: Gilles Mithieux Source Type: research

Orphan GPR146: an alternative therapeutic pathway to achieve cholesterol homeostasis?
Trends Endocrinol Metab. 2022 May 9:S1043-2760(22)00065-0. doi: 10.1016/j.tem.2022.04.008. Online ahead of print.ABSTRACTAtherosclerosis predisposes to myriad cardiovascular complications, including myocardial infarction and stroke. Statins have revolutionised cholesterol management but they do not work for all patients, particularly those with familial hypercholesterolaemia (FH). Genome-wide association studies have linked SNPs at orphan G protein-coupled receptor 146 (GPR146) to human atherosclerosis but how GPR146 influences serum cholesterol homeostasis was only recently described. Gpr146 deletion in mice reduces serum...
Source: Trends in Endocrinology and Metabolism: TEM - May 13, 2022 Category: Endocrinology Authors: Brendan P Wilkins Angela M Finch Yan Wang Nicola J Smith Source Type: research

Orphan GPR146: an alternative therapeutic pathway to achieve cholesterol homeostasis?
Trends Endocrinol Metab. 2022 May 9:S1043-2760(22)00065-0. doi: 10.1016/j.tem.2022.04.008. Online ahead of print.ABSTRACTAtherosclerosis predisposes to myriad cardiovascular complications, including myocardial infarction and stroke. Statins have revolutionised cholesterol management but they do not work for all patients, particularly those with familial hypercholesterolaemia (FH). Genome-wide association studies have linked SNPs at orphan G protein-coupled receptor 146 (GPR146) to human atherosclerosis but how GPR146 influences serum cholesterol homeostasis was only recently described. Gpr146 deletion in mice reduces serum...
Source: Trends in Endocrinology and Metabolism: TEM - May 13, 2022 Category: Endocrinology Authors: Brendan P Wilkins Angela M Finch Yan Wang Nicola J Smith Source Type: research

Orphan GPR146: an alternative therapeutic pathway to achieve cholesterol homeostasis?
Trends Endocrinol Metab. 2022 May 9:S1043-2760(22)00065-0. doi: 10.1016/j.tem.2022.04.008. Online ahead of print.ABSTRACTAtherosclerosis predisposes to myriad cardiovascular complications, including myocardial infarction and stroke. Statins have revolutionised cholesterol management but they do not work for all patients, particularly those with familial hypercholesterolaemia (FH). Genome-wide association studies have linked SNPs at orphan G protein-coupled receptor 146 (GPR146) to human atherosclerosis but how GPR146 influences serum cholesterol homeostasis was only recently described. Gpr146 deletion in mice reduces serum...
Source: Trends in Endocrinology and Metabolism: TEM - May 13, 2022 Category: Endocrinology Authors: Brendan P Wilkins Angela M Finch Yan Wang Nicola J Smith Source Type: research

Orphan GPR146: an alternative therapeutic pathway to achieve cholesterol homeostasis?
Trends Endocrinol Metab. 2022 May 9:S1043-2760(22)00065-0. doi: 10.1016/j.tem.2022.04.008. Online ahead of print.ABSTRACTAtherosclerosis predisposes to myriad cardiovascular complications, including myocardial infarction and stroke. Statins have revolutionised cholesterol management but they do not work for all patients, particularly those with familial hypercholesterolaemia (FH). Genome-wide association studies have linked SNPs at orphan G protein-coupled receptor 146 (GPR146) to human atherosclerosis but how GPR146 influences serum cholesterol homeostasis was only recently described. Gpr146 deletion in mice reduces serum...
Source: Trends in Endocrinology and Metabolism: TEM - May 13, 2022 Category: Endocrinology Authors: Brendan P Wilkins Angela M Finch Yan Wang Nicola J Smith Source Type: research

Orphan GPR146: an alternative therapeutic pathway to achieve cholesterol homeostasis?
Trends Endocrinol Metab. 2022 May 9:S1043-2760(22)00065-0. doi: 10.1016/j.tem.2022.04.008. Online ahead of print.ABSTRACTAtherosclerosis predisposes to myriad cardiovascular complications, including myocardial infarction and stroke. Statins have revolutionised cholesterol management but they do not work for all patients, particularly those with familial hypercholesterolaemia (FH). Genome-wide association studies have linked SNPs at orphan G protein-coupled receptor 146 (GPR146) to human atherosclerosis but how GPR146 influences serum cholesterol homeostasis was only recently described. Gpr146 deletion in mice reduces serum...
Source: Trends in Endocrinology and Metabolism: TEM - May 13, 2022 Category: Endocrinology Authors: Brendan P Wilkins Angela M Finch Yan Wang Nicola J Smith Source Type: research

Treatment of hypothyroidism in infants, children and adolescents
Trends Endocrinol Metab. 2022 May 7:S1043-2760(22)00064-9. doi: 10.1016/j.tem.2022.04.007. Online ahead of print.ABSTRACTIn 2014, treatment guidelines from the American Thyroid Association reflected the general consensus that levothyroxine (LT4), adjusted to maintain a normal thyrotropin (TSH) level, is the preferred method for treatment of hypothyroidism. Although this is generally applicable to children, there are subsets of children for whom the diagnosis and treatment of hypothyroidism are problematic. These include children with congenital hypothyroidism (CH), low birth weight (LBW) and very low birth weight (VLBW), D...
Source: Trends in Endocrinology and Metabolism: TEM - May 10, 2022 Category: Endocrinology Authors: Luisa Rodriguez Catherine Dinauer Gary Francis Source Type: research