Mitochondrial quality control pathways sense mitochondrial protein import
Trends Endocrinol Metab. 2023 Dec 15:S1043-2760(23)00243-6. doi: 10.1016/j.tem.2023.11.004. Online ahead of print.ABSTRACTMitochondrial quality control (MQC) mechanisms are required to maintain a functional proteome, which enables mitochondria to perform a myriad of important cellular functions from oxidative phosphorylation to numerous other metabolic pathways. Mitochondrial protein homeostasis begins with the import of over 1000 nuclear-encoded mitochondrial proteins and the synthesis of 13 mitochondrial DNA-encoded proteins. A network of chaperones and proteases helps to fold new proteins and degrade unnecessary, damage...
Source: Trends in Endocrinology and Metabolism: TEM - December 16, 2023 Category: Endocrinology Authors: Laurie P Lee-Glover Timothy E Shutt Source Type: research

Irisin limits amyloid- β buildup in Alzheimer's disease
Trends Endocrinol Metab. 2023 Dec 14:S1043-2760(23)00245-X. doi: 10.1016/j.tem.2023.11.006. Online ahead of print.ABSTRACTMounting evidence suggests that physical exercise protects the brain against neurodegenerative disease. In a recent paper in Neuron, Kim et al. reported that the exercise-induced hormone irisin curbs amyloid-β buildup by promoting secretion of astrocyte-derived neprilysin. These findings may help explain the neuroprotection by irisin and exercise in Alzheimer's disease.PMID:38101996 | DOI:10.1016/j.tem.2023.11.006 (Source: Trends in Endocrinology and Metabolism: TEM)
Source: Trends in Endocrinology and Metabolism: TEM - December 15, 2023 Category: Endocrinology Authors: Mychael V Lourenco Source Type: research

Fructose promotes liver cancer via microbial acetate-induced O-GlcNAcylation
Trends Endocrinol Metab. 2023 Dec 13:S1043-2760(23)00247-3. doi: 10.1016/j.tem.2023.12.002. Online ahead of print.ABSTRACTHigh dietary fructose consumption is linked to multiple disease states, including cancer. Zhou and colleagues recently reported a novel mechanism where high dietary fructose levels increase acetate production by the gut microbiome increasing post-translational modification O-GlcNAcylation in liver cells, which contributes to disease progression in mouse models of hepatocellular carcinoma.PMID:38097465 | DOI:10.1016/j.tem.2023.12.002 (Source: Trends in Endocrinology and Metabolism: TEM)
Source: Trends in Endocrinology and Metabolism: TEM - December 14, 2023 Category: Endocrinology Authors: Emily M Esquea Riley G Young Mauricio J Reginato Source Type: research

Fructose promotes liver cancer via microbial acetate-induced O-GlcNAcylation
Trends Endocrinol Metab. 2023 Dec 13:S1043-2760(23)00247-3. doi: 10.1016/j.tem.2023.12.002. Online ahead of print.ABSTRACTHigh dietary fructose consumption is linked to multiple disease states, including cancer. Zhou and colleagues recently reported a novel mechanism where high dietary fructose levels increase acetate production by the gut microbiome increasing post-translational modification O-GlcNAcylation in liver cells, which contributes to disease progression in mouse models of hepatocellular carcinoma.PMID:38097465 | DOI:10.1016/j.tem.2023.12.002 (Source: Trends in Endocrinology and Metabolism: TEM)
Source: Trends in Endocrinology and Metabolism: TEM - December 14, 2023 Category: Endocrinology Authors: Emily M Esquea Riley G Young Mauricio J Reginato Source Type: research

Metabolic challengers selecting tumor-persistent cells
Trends Endocrinol Metab. 2023 Dec 9:S1043-2760(23)00244-8. doi: 10.1016/j.tem.2023.11.005. Online ahead of print.ABSTRACTResistance to anticancer therapy still represents one of the main obstacles to cancer treatment. Numerous components of the tumor microenvironment (TME) contribute significantly to the acquisition of drug resistance. Microenvironmental pressures arising during cancer evolution foster tumor heterogeneity (TH) and facilitate the emergence of drug-resistant clones. In particular, metabolic pressures arising in the TME may favor epigenetic adaptations supporting the acquisition of persistence features in tum...
Source: Trends in Endocrinology and Metabolism: TEM - December 9, 2023 Category: Endocrinology Authors: Caterina Mancini Giulia Lori Erica Pranzini Maria Letizia Taddei Source Type: research

Metabolic challengers selecting tumor-persistent cells
Trends Endocrinol Metab. 2023 Dec 9:S1043-2760(23)00244-8. doi: 10.1016/j.tem.2023.11.005. Online ahead of print.ABSTRACTResistance to anticancer therapy still represents one of the main obstacles to cancer treatment. Numerous components of the tumor microenvironment (TME) contribute significantly to the acquisition of drug resistance. Microenvironmental pressures arising during cancer evolution foster tumor heterogeneity (TH) and facilitate the emergence of drug-resistant clones. In particular, metabolic pressures arising in the TME may favor epigenetic adaptations supporting the acquisition of persistence features in tum...
Source: Trends in Endocrinology and Metabolism: TEM - December 9, 2023 Category: Endocrinology Authors: Caterina Mancini Giulia Lori Erica Pranzini Maria Letizia Taddei Source Type: research

Metabolic challengers selecting tumor-persistent cells
Trends Endocrinol Metab. 2023 Dec 9:S1043-2760(23)00244-8. doi: 10.1016/j.tem.2023.11.005. Online ahead of print.ABSTRACTResistance to anticancer therapy still represents one of the main obstacles to cancer treatment. Numerous components of the tumor microenvironment (TME) contribute significantly to the acquisition of drug resistance. Microenvironmental pressures arising during cancer evolution foster tumor heterogeneity (TH) and facilitate the emergence of drug-resistant clones. In particular, metabolic pressures arising in the TME may favor epigenetic adaptations supporting the acquisition of persistence features in tum...
Source: Trends in Endocrinology and Metabolism: TEM - December 9, 2023 Category: Endocrinology Authors: Caterina Mancini Giulia Lori Erica Pranzini Maria Letizia Taddei Source Type: research

Metabolic challengers selecting tumor-persistent cells
Trends Endocrinol Metab. 2023 Dec 9:S1043-2760(23)00244-8. doi: 10.1016/j.tem.2023.11.005. Online ahead of print.ABSTRACTResistance to anticancer therapy still represents one of the main obstacles to cancer treatment. Numerous components of the tumor microenvironment (TME) contribute significantly to the acquisition of drug resistance. Microenvironmental pressures arising during cancer evolution foster tumor heterogeneity (TH) and facilitate the emergence of drug-resistant clones. In particular, metabolic pressures arising in the TME may favor epigenetic adaptations supporting the acquisition of persistence features in tum...
Source: Trends in Endocrinology and Metabolism: TEM - December 9, 2023 Category: Endocrinology Authors: Caterina Mancini Giulia Lori Erica Pranzini Maria Letizia Taddei Source Type: research

Metabolic challengers selecting tumor-persistent cells
Trends Endocrinol Metab. 2023 Dec 9:S1043-2760(23)00244-8. doi: 10.1016/j.tem.2023.11.005. Online ahead of print.ABSTRACTResistance to anticancer therapy still represents one of the main obstacles to cancer treatment. Numerous components of the tumor microenvironment (TME) contribute significantly to the acquisition of drug resistance. Microenvironmental pressures arising during cancer evolution foster tumor heterogeneity (TH) and facilitate the emergence of drug-resistant clones. In particular, metabolic pressures arising in the TME may favor epigenetic adaptations supporting the acquisition of persistence features in tum...
Source: Trends in Endocrinology and Metabolism: TEM - December 9, 2023 Category: Endocrinology Authors: Caterina Mancini Giulia Lori Erica Pranzini Maria Letizia Taddei Source Type: research

The evolutionary tug-of-war of macrophage metabolism during bacterial infection
Trends Endocrinol Metab. 2023 Nov 30:S1043-2760(23)00241-2. doi: 10.1016/j.tem.2023.11.002. Online ahead of print.ABSTRACTThe function and phenotype of macrophages are intimately linked with pathogen detection. On sensing pathogen-derived signals and molecules, macrophages undergo a carefully orchestrated process of polarization to acquire pathogen-clearing properties. This phenotypic change must be adequately supported by metabolic reprogramming that is now known to support the acquisition of effector function, but also generates secondary metabolites with direct microbicidal activity. At the same time, bacteria themselve...
Source: Trends in Endocrinology and Metabolism: TEM - December 1, 2023 Category: Endocrinology Authors: Lu ís Almeida Ayesha Dhillon-LaBrooy Tim Sparwasser Source Type: research

The ups and downs of bone-marrow adipose tissue in space
Trends Endocrinol Metab. 2023 Nov 30:S1043-2760(23)00242-4. doi: 10.1016/j.tem.2023.11.003. Online ahead of print.ABSTRACTKnowledge is rapidly accumulating on basic roles and modulation of bone-marrow adipose tissue (BMAT). Among key modulators are physical forces on bones as exerted by gravity and exercise. Studying humans returning from space has revealed that, in addition to physical forces, local energetics within the bone marrow can play modulatory roles.PMID:38040579 | DOI:10.1016/j.tem.2023.11.003 (Source: Trends in Endocrinology and Metabolism: TEM)
Source: Trends in Endocrinology and Metabolism: TEM - December 1, 2023 Category: Endocrinology Authors: Guy Trudel Gerd Melkus Tammy Liu Source Type: research

The evolutionary tug-of-war of macrophage metabolism during bacterial infection
Trends Endocrinol Metab. 2023 Nov 30:S1043-2760(23)00241-2. doi: 10.1016/j.tem.2023.11.002. Online ahead of print.ABSTRACTThe function and phenotype of macrophages are intimately linked with pathogen detection. On sensing pathogen-derived signals and molecules, macrophages undergo a carefully orchestrated process of polarization to acquire pathogen-clearing properties. This phenotypic change must be adequately supported by metabolic reprogramming that is now known to support the acquisition of effector function, but also generates secondary metabolites with direct microbicidal activity. At the same time, bacteria themselve...
Source: Trends in Endocrinology and Metabolism: TEM - December 1, 2023 Category: Endocrinology Authors: Lu ís Almeida Ayesha Dhillon-LaBrooy Tim Sparwasser Source Type: research

The ups and downs of bone-marrow adipose tissue in space
Trends Endocrinol Metab. 2023 Nov 30:S1043-2760(23)00242-4. doi: 10.1016/j.tem.2023.11.003. Online ahead of print.ABSTRACTKnowledge is rapidly accumulating on basic roles and modulation of bone-marrow adipose tissue (BMAT). Among key modulators are physical forces on bones as exerted by gravity and exercise. Studying humans returning from space has revealed that, in addition to physical forces, local energetics within the bone marrow can play modulatory roles.PMID:38040579 | DOI:10.1016/j.tem.2023.11.003 (Source: Trends in Endocrinology and Metabolism: TEM)
Source: Trends in Endocrinology and Metabolism: TEM - December 1, 2023 Category: Endocrinology Authors: Guy Trudel Gerd Melkus Tammy Liu Source Type: research

The evolutionary tug-of-war of macrophage metabolism during bacterial infection
Trends Endocrinol Metab. 2023 Nov 30:S1043-2760(23)00241-2. doi: 10.1016/j.tem.2023.11.002. Online ahead of print.ABSTRACTThe function and phenotype of macrophages are intimately linked with pathogen detection. On sensing pathogen-derived signals and molecules, macrophages undergo a carefully orchestrated process of polarization to acquire pathogen-clearing properties. This phenotypic change must be adequately supported by metabolic reprogramming that is now known to support the acquisition of effector function, but also generates secondary metabolites with direct microbicidal activity. At the same time, bacteria themselve...
Source: Trends in Endocrinology and Metabolism: TEM - December 1, 2023 Category: Endocrinology Authors: Lu ís Almeida Ayesha Dhillon-LaBrooy Tim Sparwasser Source Type: research

The ups and downs of bone-marrow adipose tissue in space
Trends Endocrinol Metab. 2023 Nov 30:S1043-2760(23)00242-4. doi: 10.1016/j.tem.2023.11.003. Online ahead of print.ABSTRACTKnowledge is rapidly accumulating on basic roles and modulation of bone-marrow adipose tissue (BMAT). Among key modulators are physical forces on bones as exerted by gravity and exercise. Studying humans returning from space has revealed that, in addition to physical forces, local energetics within the bone marrow can play modulatory roles.PMID:38040579 | DOI:10.1016/j.tem.2023.11.003 (Source: Trends in Endocrinology and Metabolism: TEM)
Source: Trends in Endocrinology and Metabolism: TEM - December 1, 2023 Category: Endocrinology Authors: Guy Trudel Gerd Melkus Tammy Liu Source Type: research