Trends in Endocrinology and Metabolism: TEM 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Recreating metabolic interactions of the tumour microenvironment
Trends Endocrinol Metab. 2024 Jan 10:S1043-2760(23)00250-3. doi: 10.1016/j.tem.2023.12.005. Online ahead of print.ABSTRACTTumours are heterogeneous tissues containing diverse populations of cells and an abundant extracellular matrix (ECM). This tumour microenvironment prompts cancer cells to adapt their metabolism to survive and grow. Besides epigenetic factors, the metabolism of cancer cells is shaped by crosstalk with stromal cells and extracellular components. To date, most experimental models neglect the complexity of the tumour microenvironment and its relevance in regulating the dynamics of the metabolism in cancer. ...
Source: Trends in Endocrinology and Metabolism: TEM - January 11, 2024 Category: Endocrinology Authors: Rodrigo Curvello Nikolaus Berndt Sandra Hauser Daniela Loessner Source Type: research
The impact of epitranscriptomic modifications on liver disease
Trends Endocrinol Metab. 2024 Jan 10:S1043-2760(23)00272-2. doi: 10.1016/j.tem.2023.12.007. Online ahead of print.ABSTRACTRNA modifications have emerged as important mechanisms of gene regulation. Developmental, metabolic, and cell cycle regulatory processes are all affected by epitranscriptomic modifications, which control gene expression in a dynamic manner. The hepatic tissue is highly metabolically active and has an impressive ability to regenerate after injury. Cell proliferation, differentiation, and metabolism, which are all essential to the liver response to injury and regeneration, are regulated via RNA modificati...
Source: Trends in Endocrinology and Metabolism: TEM - January 11, 2024 Category: Endocrinology Authors: Keith A Berggren Robert E Schwartz Ralph E Kleiner Alexander Ploss Source Type: research
Exploring the relationship between hyperlactatemia and anemia
Trends Endocrinol Metab. 2024 Jan 6:S1043-2760(23)00251-5. doi: 10.1016/j.tem.2023.12.006. Online ahead of print.ABSTRACTHyperlactatemia and anemia commonly coexist and their crosstalk is a longstanding mystery with elusive mechanisms involved in physical activities, infections, cancers, and genetic disorders. For instance, hyperlactatemia leads to iron restriction by upregulating hepatic hepcidin expression. Increasing evidence also points to lactate as a crucial signaling molecule rather than merely a metabolic byproduct. Here, we discuss the mutual influence between anemia and hyperlactatemia. This opinion calls for a r...
Source: Trends in Endocrinology and Metabolism: TEM - January 7, 2024 Category: Endocrinology Authors: Shuping Zhang Wei Liu Tomas Ganz Sijin Liu Source Type: research
Exploring the relationship between hyperlactatemia and anemia
Trends Endocrinol Metab. 2024 Jan 6:S1043-2760(23)00251-5. doi: 10.1016/j.tem.2023.12.006. Online ahead of print.ABSTRACTHyperlactatemia and anemia commonly coexist and their crosstalk is a longstanding mystery with elusive mechanisms involved in physical activities, infections, cancers, and genetic disorders. For instance, hyperlactatemia leads to iron restriction by upregulating hepatic hepcidin expression. Increasing evidence also points to lactate as a crucial signaling molecule rather than merely a metabolic byproduct. Here, we discuss the mutual influence between anemia and hyperlactatemia. This opinion calls for a r...
Source: Trends in Endocrinology and Metabolism: TEM - January 7, 2024 Category: Endocrinology Authors: Shuping Zhang Wei Liu Tomas Ganz Sijin Liu Source Type: research
Exploring the relationship between hyperlactatemia and anemia
Trends Endocrinol Metab. 2024 Jan 6:S1043-2760(23)00251-5. doi: 10.1016/j.tem.2023.12.006. Online ahead of print.ABSTRACTHyperlactatemia and anemia commonly coexist and their crosstalk is a longstanding mystery with elusive mechanisms involved in physical activities, infections, cancers, and genetic disorders. For instance, hyperlactatemia leads to iron restriction by upregulating hepatic hepcidin expression. Increasing evidence also points to lactate as a crucial signaling molecule rather than merely a metabolic byproduct. Here, we discuss the mutual influence between anemia and hyperlactatemia. This opinion calls for a r...
Source: Trends in Endocrinology and Metabolism: TEM - January 7, 2024 Category: Endocrinology Authors: Shuping Zhang Wei Liu Tomas Ganz Sijin Liu Source Type: research
RNAkines are secreted messengers shaping health and disease
Trends Endocrinol Metab. 2023 Dec 29:S1043-2760(23)00249-7. doi: 10.1016/j.tem.2023.12.004. Online ahead of print.ABSTRACTExtracellular noncoding RNAs (ncRNAs) have crucial roles in intercellular communications. The process of ncRNA secretion is highly regulated, with specific ncRNA profiles produced under different physiological and pathological circumstances. These ncRNAs are transported primarily via extracellular vesicles (EVs) from their origin cells to target cells, utilising both endocrine and paracrine pathways. The intercellular impacts of extracellular ncRNAs are essential for maintaining homeostasis and the path...
Source: Trends in Endocrinology and Metabolism: TEM - December 30, 2023 Category: Endocrinology Authors: Jing Li Jingwen Fang Xiaohong Jiang Yujing Zhang Antonio Vidal-Puig Chen-Yu Zhang Source Type: research
RNAkines are secreted messengers shaping health and disease
Trends Endocrinol Metab. 2023 Dec 29:S1043-2760(23)00249-7. doi: 10.1016/j.tem.2023.12.004. Online ahead of print.ABSTRACTExtracellular noncoding RNAs (ncRNAs) have crucial roles in intercellular communications. The process of ncRNA secretion is highly regulated, with specific ncRNA profiles produced under different physiological and pathological circumstances. These ncRNAs are transported primarily via extracellular vesicles (EVs) from their origin cells to target cells, utilising both endocrine and paracrine pathways. The intercellular impacts of extracellular ncRNAs are essential for maintaining homeostasis and the path...
Source: Trends in Endocrinology and Metabolism: TEM - December 30, 2023 Category: Endocrinology Authors: Jing Li Jingwen Fang Xiaohong Jiang Yujing Zhang Antonio Vidal-Puig Chen-Yu Zhang Source Type: research
RNAkines are secreted messengers shaping health and disease
Trends Endocrinol Metab. 2023 Dec 29:S1043-2760(23)00249-7. doi: 10.1016/j.tem.2023.12.004. Online ahead of print.ABSTRACTExtracellular noncoding RNAs (ncRNAs) have crucial roles in intercellular communications. The process of ncRNA secretion is highly regulated, with specific ncRNA profiles produced under different physiological and pathological circumstances. These ncRNAs are transported primarily via extracellular vesicles (EVs) from their origin cells to target cells, utilising both endocrine and paracrine pathways. The intercellular impacts of extracellular ncRNAs are essential for maintaining homeostasis and the path...
Source: Trends in Endocrinology and Metabolism: TEM - December 30, 2023 Category: Endocrinology Authors: Jing Li Jingwen Fang Xiaohong Jiang Yujing Zhang Antonio Vidal-Puig Chen-Yu Zhang Source Type: research
RNAkines are secreted messengers shaping health and disease
Trends Endocrinol Metab. 2023 Dec 29:S1043-2760(23)00249-7. doi: 10.1016/j.tem.2023.12.004. Online ahead of print.ABSTRACTExtracellular noncoding RNAs (ncRNAs) have crucial roles in intercellular communications. The process of ncRNA secretion is highly regulated, with specific ncRNA profiles produced under different physiological and pathological circumstances. These ncRNAs are transported primarily via extracellular vesicles (EVs) from their origin cells to target cells, utilising both endocrine and paracrine pathways. The intercellular impacts of extracellular ncRNAs are essential for maintaining homeostasis and the path...
Source: Trends in Endocrinology and Metabolism: TEM - December 30, 2023 Category: Endocrinology Authors: Jing Li Jingwen Fang Xiaohong Jiang Yujing Zhang Antonio Vidal-Puig Chen-Yu Zhang Source Type: research
A clinical perspective on ectopic Cushing's syndrome
Trends Endocrinol Metab. 2023 Dec 23:S1043-2760(23)00248-5. doi: 10.1016/j.tem.2023.12.003. Online ahead of print.ABSTRACTCushing's syndrome (CS) refers to the clinical features of prolonged pathological glucocorticoid excess. About 10-20% of individuals with CS have ectopic CS (ECS), that is, an adrenocorticotropin (ACTH)-producing tumour outside the pituitary gland. ACTH-secreting neuroendocrine neoplasia (NENs) can arise from many organs, although bronchial NEN, small cell lung cancer (SCLC), pancreatic NEN, thymic NEN, medullary thyroid cancer (MTC), and pheochromocytoma are the most common. Patients with ECS frequentl...
Source: Trends in Endocrinology and Metabolism: TEM - December 24, 2023 Category: Endocrinology Authors: Oskar Ragnarsson C Christofer Juhlin David J Torpy Henrik Falhammar Source Type: research
A clinical perspective on ectopic Cushing's syndrome
Trends Endocrinol Metab. 2023 Dec 23:S1043-2760(23)00248-5. doi: 10.1016/j.tem.2023.12.003. Online ahead of print.ABSTRACTCushing's syndrome (CS) refers to the clinical features of prolonged pathological glucocorticoid excess. About 10-20% of individuals with CS have ectopic CS (ECS), that is, an adrenocorticotropin (ACTH)-producing tumour outside the pituitary gland. ACTH-secreting neuroendocrine neoplasia (NENs) can arise from many organs, although bronchial NEN, small cell lung cancer (SCLC), pancreatic NEN, thymic NEN, medullary thyroid cancer (MTC), and pheochromocytoma are the most common. Patients with ECS frequentl...
Source: Trends in Endocrinology and Metabolism: TEM - December 24, 2023 Category: Endocrinology Authors: Oskar Ragnarsson C Christofer Juhlin David J Torpy Henrik Falhammar Source Type: research
A clinical perspective on ectopic Cushing's syndrome
Trends Endocrinol Metab. 2023 Dec 23:S1043-2760(23)00248-5. doi: 10.1016/j.tem.2023.12.003. Online ahead of print.ABSTRACTCushing's syndrome (CS) refers to the clinical features of prolonged pathological glucocorticoid excess. About 10-20% of individuals with CS have ectopic CS (ECS), that is, an adrenocorticotropin (ACTH)-producing tumour outside the pituitary gland. ACTH-secreting neuroendocrine neoplasia (NENs) can arise from many organs, although bronchial NEN, small cell lung cancer (SCLC), pancreatic NEN, thymic NEN, medullary thyroid cancer (MTC), and pheochromocytoma are the most common. Patients with ECS frequentl...
Source: Trends in Endocrinology and Metabolism: TEM - December 24, 2023 Category: Endocrinology Authors: Oskar Ragnarsson C Christofer Juhlin David J Torpy Henrik Falhammar Source Type: research
A clinical perspective on ectopic Cushing's syndrome
Trends Endocrinol Metab. 2023 Dec 23:S1043-2760(23)00248-5. doi: 10.1016/j.tem.2023.12.003. Online ahead of print.ABSTRACTCushing's syndrome (CS) refers to the clinical features of prolonged pathological glucocorticoid excess. About 10-20% of individuals with CS have ectopic CS (ECS), that is, an adrenocorticotropin (ACTH)-producing tumour outside the pituitary gland. ACTH-secreting neuroendocrine neoplasia (NENs) can arise from many organs, although bronchial NEN, small cell lung cancer (SCLC), pancreatic NEN, thymic NEN, medullary thyroid cancer (MTC), and pheochromocytoma are the most common. Patients with ECS frequentl...
Source: Trends in Endocrinology and Metabolism: TEM - December 24, 2023 Category: Endocrinology Authors: Oskar Ragnarsson C Christofer Juhlin David J Torpy Henrik Falhammar Source Type: research
A clinical perspective on ectopic Cushing's syndrome
Trends Endocrinol Metab. 2023 Dec 23:S1043-2760(23)00248-5. doi: 10.1016/j.tem.2023.12.003. Online ahead of print.ABSTRACTCushing's syndrome (CS) refers to the clinical features of prolonged pathological glucocorticoid excess. About 10-20% of individuals with CS have ectopic CS (ECS), that is, an adrenocorticotropin (ACTH)-producing tumour outside the pituitary gland. ACTH-secreting neuroendocrine neoplasia (NENs) can arise from many organs, although bronchial NEN, small cell lung cancer (SCLC), pancreatic NEN, thymic NEN, medullary thyroid cancer (MTC), and pheochromocytoma are the most common. Patients with ECS frequentl...
Source: Trends in Endocrinology and Metabolism: TEM - December 24, 2023 Category: Endocrinology Authors: Oskar Ragnarsson C Christofer Juhlin David J Torpy Henrik Falhammar Source Type: research
A clinical perspective on ectopic Cushing's syndrome
Trends Endocrinol Metab. 2023 Dec 23:S1043-2760(23)00248-5. doi: 10.1016/j.tem.2023.12.003. Online ahead of print.ABSTRACTCushing's syndrome (CS) refers to the clinical features of prolonged pathological glucocorticoid excess. About 10-20% of individuals with CS have ectopic CS (ECS), that is, an adrenocorticotropin (ACTH)-producing tumour outside the pituitary gland. ACTH-secreting neuroendocrine neoplasia (NENs) can arise from many organs, although bronchial NEN, small cell lung cancer (SCLC), pancreatic NEN, thymic NEN, medullary thyroid cancer (MTC), and pheochromocytoma are the most common. Patients with ECS frequentl...
Source: Trends in Endocrinology and Metabolism: TEM - December 24, 2023 Category: Endocrinology Authors: Oskar Ragnarsson C Christofer Juhlin David J Torpy Henrik Falhammar Source Type: research
