Trends in Endocrinology and Metabolism: TEM 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Vitamin K-dependent carboxylation in β-cells and diabetes
Trends Endocrinol Metab. 2024 Feb 29:S1043-2760(24)00035-3. doi: 10.1016/j.tem.2024.02.006. Online ahead of print.ABSTRACTVitamin K is an essential micronutrient and a cofactor for the enzyme γ-glutamyl carboxylase, which adds a carboxyl group to specific glutamic acid residues in proteins transiting through the secretory pathway. Higher vitamin K intake has been linked to a reduced incidence of type 2 diabetes (T2D) in humans. Preclinical work suggests that this effect depends on the γ-carboxylation of specific proteins in β-cells, including endoplasmic reticulum Gla protein (ERGP), implicated in the control of intrace...
Source: Trends in Endocrinology and Metabolism: TEM - March 1, 2024 Category: Endocrinology Authors: Julie Lacombe Mathieu Ferron Source Type: research
Current status and future trends of the global burden of MASLD
Trends Endocrinol Metab. 2024 Feb 29:S1043-2760(24)00036-5. doi: 10.1016/j.tem.2024.02.007. Online ahead of print.ABSTRACTMetabolic dysfunction-associated steatotic liver disease (MASLD) has emerged as the most common chronic liver disease globally, affecting more than a third of the world's adult population. This comprehensive narrative review summarizes the global incidence and prevalence rates of MASLD and its related adverse hepatic and extrahepatic outcomes. We also discuss the substantial economic burden of MASLD on healthcare systems, thus further highlighting the urgent need for global efforts to tackle this common...
Source: Trends in Endocrinology and Metabolism: TEM - March 1, 2024 Category: Endocrinology Authors: Lei Miao Giovanni Targher Christopher D Byrne Ying-Ying Cao Ming-Hua Zheng Source Type: research
Evolving liver disease insights from NAFLD to MASLD
Trends Endocrinol Metab. 2024 Feb 29:S1043-2760(24)00041-9. doi: 10.1016/j.tem.2024.02.012. Online ahead of print.ABSTRACTThe recent renaming of 'non-alcoholic fatty liver disease' (NAFLD) to 'metabolic dysfunction-associated steatotic liver disease' (MASLD) emphasizes metabolic dysfunction in steatotic liver disease and advocates for tailored, comprehensive treatment strategies, driving forward the development of personalized care and innovative therapeutic approaches.PMID:38429162 | DOI:10.1016/j.tem.2024.02.012 (Source: Trends in Endocrinology and Metabolism: TEM)
Source: Trends in Endocrinology and Metabolism: TEM - March 1, 2024 Category: Endocrinology Authors: Xiude Fan Yongfeng Song Jiajun Zhao Source Type: research
Parathyroid hormone-PTH1R signaling in cardiovascular disease and homeostasis
Trends Endocrinol Metab. 2024 Feb 29:S1043-2760(24)00034-1. doi: 10.1016/j.tem.2024.02.005. Online ahead of print.ABSTRACTPrimary hyperparathyroidism (pHPT) afflicts our aging population with an incidence approaching 50 per 100 000 patient-years at a female:male ratio of ~3:1. Decisions surrounding surgical management are currently driven by age, hypercalcemia severity, presence of osteoporosis, renal insufficiency, or hypercalciuria with or without nephrolithiasis. Cardiovascular (CV) disease (CVD) is not systematically considered. This is notable since the parathyroid hormone (PTH) 1 receptor (PTH1R) is biologically acti...
Source: Trends in Endocrinology and Metabolism: TEM - March 1, 2024 Category: Endocrinology Authors: Dwight A Towler Source Type: research
Systemic and organ-specific anti-inflammatory effects of sodium-glucose cotransporter-2 inhibitors
Trends Endocrinol Metab. 2024 Feb 29:S1043-2760(24)00032-8. doi: 10.1016/j.tem.2024.02.003. Online ahead of print.ABSTRACTInflammation plays an essential role and is a common feature in the pathogenesis of many chronic diseases. The exact mechanisms through which sodium-glucose cotransporter-2 (SGLT2) inhibitors achieve their much-acclaimed clinical benefits largely remain unknown. In this review, we detail the systemic and tissue- or organ-specific anti-inflammatory effects of SGLT2 inhibitors using evidence from animal and human studies. We discuss the potential pathways through which SGLT2 inhibitors exert their anti-in...
Source: Trends in Endocrinology and Metabolism: TEM - February 29, 2024 Category: Endocrinology Authors: Mona Mashayekhi Bilgunay Ilkin Safa Matthew S C Gonzalez Sangwon F Kim Justin B Echouffo-Tcheugui Source Type: research
Nucleosides are overlooked fuels in central carbon metabolism
Trends Endocrinol Metab. 2024 Feb 29:S1043-2760(24)00027-4. doi: 10.1016/j.tem.2024.01.013. Online ahead of print.ABSTRACTFrom our daily nutrition and synthesis within cells, nucleosides enter the bloodstream and circulate throughout the body and tissues. Nucleosides and nucleotides are classically viewed as precursors of nucleic acids, but recently they have emerged as a novel energy source for central carbon metabolism. Through catabolism by nucleoside phosphorylases, the ribose sugar group is released and can provide substrates for lower steps in glycolysis. In environments with limited glucose, such as at sites of infe...
Source: Trends in Endocrinology and Metabolism: TEM - February 29, 2024 Category: Endocrinology Authors: Abigail Strefeler Joan Blanco-Fernandez Alexis A Jourdain Source Type: research
Current status and future perspectives of FGF21 analogues in clinical trials
Trends Endocrinol Metab. 2024 Feb 28:S1043-2760(24)00028-6. doi: 10.1016/j.tem.2024.02.001. Online ahead of print.ABSTRACTRecent advances in fibroblast growth factor 21 (FGF21) biology and pharmacology have led to the development of several long-acting FGF21 analogues and antibody-based mimetics now in various phases of clinical trials for the treatment of obesity-related metabolic comorbidities. The efficacy of these FGF21 analogues/mimetics on glycaemic control and weight loss is rather mild and inconsistent; nevertheless, several promising therapeutic benefits have been reproducibly observed in most clinical studies, in...
Source: Trends in Endocrinology and Metabolism: TEM - February 29, 2024 Category: Endocrinology Authors: Zara Siu Wa Chui Qing Shen Aimin Xu Source Type: research
Systemic and organ-specific anti-inflammatory effects of sodium-glucose cotransporter-2 inhibitors
Trends Endocrinol Metab. 2024 Feb 29:S1043-2760(24)00032-8. doi: 10.1016/j.tem.2024.02.003. Online ahead of print.ABSTRACTInflammation plays an essential role and is a common feature in the pathogenesis of many chronic diseases. The exact mechanisms through which sodium-glucose cotransporter-2 (SGLT2) inhibitors achieve their much-acclaimed clinical benefits largely remain unknown. In this review, we detail the systemic and tissue- or organ-specific anti-inflammatory effects of SGLT2 inhibitors using evidence from animal and human studies. We discuss the potential pathways through which SGLT2 inhibitors exert their anti-in...
Source: Trends in Endocrinology and Metabolism: TEM - February 29, 2024 Category: Endocrinology Authors: Mona Mashayekhi Bilgunay Ilkin Safa Matthew S C Gonzalez Sangwon F Kim Justin B Echouffo-Tcheugui Source Type: research
Nucleosides are overlooked fuels in central carbon metabolism
Trends Endocrinol Metab. 2024 Feb 29:S1043-2760(24)00027-4. doi: 10.1016/j.tem.2024.01.013. Online ahead of print.ABSTRACTFrom our daily nutrition and synthesis within cells, nucleosides enter the bloodstream and circulate throughout the body and tissues. Nucleosides and nucleotides are classically viewed as precursors of nucleic acids, but recently they have emerged as a novel energy source for central carbon metabolism. Through catabolism by nucleoside phosphorylases, the ribose sugar group is released and can provide substrates for lower steps in glycolysis. In environments with limited glucose, such as at sites of infe...
Source: Trends in Endocrinology and Metabolism: TEM - February 29, 2024 Category: Endocrinology Authors: Abigail Strefeler Joan Blanco-Fernandez Alexis A Jourdain Source Type: research
Current status and future perspectives of FGF21 analogues in clinical trials
Trends Endocrinol Metab. 2024 Feb 28:S1043-2760(24)00028-6. doi: 10.1016/j.tem.2024.02.001. Online ahead of print.ABSTRACTRecent advances in fibroblast growth factor 21 (FGF21) biology and pharmacology have led to the development of several long-acting FGF21 analogues and antibody-based mimetics now in various phases of clinical trials for the treatment of obesity-related metabolic comorbidities. The efficacy of these FGF21 analogues/mimetics on glycaemic control and weight loss is rather mild and inconsistent; nevertheless, several promising therapeutic benefits have been reproducibly observed in most clinical studies, in...
Source: Trends in Endocrinology and Metabolism: TEM - February 29, 2024 Category: Endocrinology Authors: Zara Siu Wa Chui Qing Shen Aimin Xu Source Type: research
Mitochondrial dysfunction in lipid processing and gastrointestinal disorders
Trends Endocrinol Metab. 2024 Feb 27:S1043-2760(24)00038-9. doi: 10.1016/j.tem.2024.02.009. Online ahead of print.ABSTRACTMitochondrial dysfunctions predominantly cause encephalomyopathies with muscle atrophy and neurodegeneration. However, their impact on other tissues, particularly the gastrointestinal tract, requires further investigation. In a recent report in Nature, Moschandrea et al. used mice deficient in the mitochondrial aminoacyl-tRNA synthetase DARS2 to investigate the role of enterocytic mitochondria in dietary lipid processing and transport. Their work sheds light on the development of gastrointestinal disord...
Source: Trends in Endocrinology and Metabolism: TEM - February 28, 2024 Category: Endocrinology Authors: Yan Hu Hao Huang Rong Xiang Source Type: research
Placental inflammation, oxidative stress, and fetal outcomes in maternal obesity
Trends Endocrinol Metab. 2024 Feb 28:S1043-2760(24)00031-6. doi: 10.1016/j.tem.2024.02.002. Online ahead of print.ABSTRACTThe obesity epidemic has led to a growing body of research investigating the consequences of maternal obesity on pregnancy and offspring health. The placenta, traditionally viewed as a passive intermediary between mother and fetus, is known to play a critical role in modulating the intrauterine environment and fetal development, and we now know that maternal obesity leads to increased inflammation, oxidative stress, and altered placental function. Here, we review recent research exploring the involvemen...
Source: Trends in Endocrinology and Metabolism: TEM - February 28, 2024 Category: Endocrinology Authors: Cindy X W Zhang Alejandro A Candia Amanda N Sferruzzi-Perri Source Type: research
Mitochondrial dysfunction in lipid processing and gastrointestinal disorders
Trends Endocrinol Metab. 2024 Feb 27:S1043-2760(24)00038-9. doi: 10.1016/j.tem.2024.02.009. Online ahead of print.ABSTRACTMitochondrial dysfunctions predominantly cause encephalomyopathies with muscle atrophy and neurodegeneration. However, their impact on other tissues, particularly the gastrointestinal tract, requires further investigation. In a recent report in Nature, Moschandrea et al. used mice deficient in the mitochondrial aminoacyl-tRNA synthetase DARS2 to investigate the role of enterocytic mitochondria in dietary lipid processing and transport. Their work sheds light on the development of gastrointestinal disord...
Source: Trends in Endocrinology and Metabolism: TEM - February 28, 2024 Category: Endocrinology Authors: Yan Hu Hao Huang Rong Xiang Source Type: research
Placental inflammation, oxidative stress, and fetal outcomes in maternal obesity
Trends Endocrinol Metab. 2024 Feb 28:S1043-2760(24)00031-6. doi: 10.1016/j.tem.2024.02.002. Online ahead of print.ABSTRACTThe obesity epidemic has led to a growing body of research investigating the consequences of maternal obesity on pregnancy and offspring health. The placenta, traditionally viewed as a passive intermediary between mother and fetus, is known to play a critical role in modulating the intrauterine environment and fetal development, and we now know that maternal obesity leads to increased inflammation, oxidative stress, and altered placental function. Here, we review recent research exploring the involvemen...
Source: Trends in Endocrinology and Metabolism: TEM - February 28, 2024 Category: Endocrinology Authors: Cindy X W Zhang Alejandro A Candia Amanda N Sferruzzi-Perri Source Type: research
Lysine lactylation in the regulation of tumor biology
Trends Endocrinol Metab. 2024 Feb 22:S1043-2760(24)00025-0. doi: 10.1016/j.tem.2024.01.011. Online ahead of print.ABSTRACTLysine lactylation (Kla), a newly discovered post-translational modification (PTM) of lysine residues, is progressively revealing its crucial role in tumor biology. A growing body of evidence supports its capacity of transcriptional regulation through histone modification and modulation of non-histone protein function. It intricately participates in a myriad of events in the tumor microenvironment (TME) by orchestrating the transitions of immune states and augmenting tumor malignancy. Its preferential m...
Source: Trends in Endocrinology and Metabolism: TEM - February 23, 2024 Category: Endocrinology Authors: Zijian Yang Yingqi Zheng Qiang Gao Source Type: research
