Trends in Endocrinology and Metabolism: TEM This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Maternal nutritional programming shapes the cerebral landscape
Trends Endocrinol Metab. 2023 Nov 8:S1043-2760(23)00221-7. doi: 10.1016/j.tem.2023.10.008. Online ahead of print.ABSTRACTThe escalating prevalence of maternal obesity raises concerns about its influence on offspring health. Exposure to obesogenic environments during early development leads to persistent alterations in brain function contributing to neurological disorders. Nutritional programming emerges as a promising avenue to counteract the deleterious effects of maternal obesity on offspring neurodevelopment.PMID:37949733 | DOI:10.1016/j.tem.2023.10.008 (Source: Trends in Endocrinology and Metabolism: TEM)
Source: Trends in Endocrinology and Metabolism: TEM - November 10, 2023 Category: Endocrinology Authors: Bandy Chen Elisa de Launoit Nicolas Renier Marc Schneeberger Source Type: research

Lipid metabolism reprogramming in cardiac fibrosis
Trends Endocrinol Metab. 2023 Nov 8:S1043-2760(23)00217-5. doi: 10.1016/j.tem.2023.10.004. Online ahead of print.ABSTRACTCardiac fibrosis is a critical pathophysiological process that occurs with diverse types of cardiac injury. Lipids are the most important bioenergy substrates for maintaining optimal heart performance and act as second messengers to transduce signals within cardiac cells. However, lipid metabolism reprogramming is a double-edged sword in the regulation of cardiomyocyte homeostasis and heart function. Moreover, lipids can exert diverse effects on cardiac fibrosis through different signaling pathways. In t...
Source: Trends in Endocrinology and Metabolism: TEM - November 10, 2023 Category: Endocrinology Authors: Li-Chan Lin Zhi-Yan Liu Jing-Jing Yang Jian-Yuan Zhao Hui Tao Source Type: research

Immunometabolic biomarkers for partial remission in type 1 diabetes mellitus
Trends Endocrinol Metab. 2023 Nov 8:S1043-2760(23)00218-7. doi: 10.1016/j.tem.2023.10.005. Online ahead of print.ABSTRACTShortly after diagnosis of type 1 diabetes mellitus (T1DM) and initiation of insulin therapy, many patients experience a transient partial remission (PR) phase, also known as the honeymoon phase. This phase presents a potential therapeutic opportunity due to its association with immunoregulatory and β cell-protective mechanisms. However, the lack of biomarkers makes its characterization difficult. In this review, we cover the current literature addressing the discovery of new predictive and monitoring b...
Source: Trends in Endocrinology and Metabolism: TEM - November 10, 2023 Category: Endocrinology Authors: Laia Gomez-Mu ñoz Juan Dominguez-Bendala Ricardo L Pastori Marta Vives-Pi Source Type: research

Shaping microbiome function with a human milk-oligosaccharide synbiotic
Trends Endocrinol Metab. 2023 Nov 7:S1043-2760(23)00220-5. doi: 10.1016/j.tem.2023.10.007. Online ahead of print.ABSTRACTIn a recent article, Button and colleagues demonstrate that human milk oligosaccharides create a nutrient niche that supports reversible colonization by Bifidobacterium infantis. Using this tunable system, they assessed the impact of B. infantis on microbiome recovery after antibiotic treatment. Overall, this work highlights synbiotics as a useful approach for developing live biotherapeutic products (LBPs).PMID:37945457 | DOI:10.1016/j.tem.2023.10.007 (Source: Trends in Endocrinology and Metabolism: TEM)
Source: Trends in Endocrinology and Metabolism: TEM - November 9, 2023 Category: Endocrinology Authors: Ethel Closa Loudon Herold Matthew T Sorbara Source Type: research

Mechanisms of hepatic fatty acid oxidation and ketogenesis during fasting
Trends Endocrinol Metab. 2023 Nov 6:S1043-2760(23)00215-1. doi: 10.1016/j.tem.2023.10.002. Online ahead of print.ABSTRACTFasting is part of many weight management and health-boosting regimens. Fasting causes substantial metabolic adaptations in the liver that include the stimulation of fatty acid oxidation and ketogenesis. The induction of fatty acid oxidation and ketogenesis during fasting is mainly driven by interrelated changes in plasma levels of various hormones and an increase in plasma nonesterified fatty acid (NEFA) levels and is mediated transcriptionally by the peroxisome proliferator-activated receptor (PPAR)α,...
Source: Trends in Endocrinology and Metabolism: TEM - November 8, 2023 Category: Endocrinology Authors: Philip M M Ruppert Sander Kersten Source Type: research