Trends in Endocrinology and Metabolism: TEM This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Pioneering new frontiers in circadian medicine chronotherapies for cardiovascular health
Trends Endocrinol Metab. 2024 Mar 7:S1043-2760(24)00040-7. doi: 10.1016/j.tem.2024.02.011. Online ahead of print.ABSTRACTCardiovascular disease (CVD) is a global health concern. Circadian medicine improves cardiovascular care by aligning treatments with our body's daily rhythms and their underlying cellular circadian mechanisms. Time-based therapies, or chronotherapies, show special promise in clinical cardiology. They optimize treatment schedules for better outcomes with fewer side effects by recognizing the profound influence of rhythmic body cycles. In this review, we focus on three chronotherapy areas (medication, ligh...
Source: Trends in Endocrinology and Metabolism: TEM - March 8, 2024 Category: Endocrinology Authors: Ifene David Festus Jeri Spilberg Martin E Young Sean Cain Sepideh Khoshnevis Michael H Smolensky Fariya Zaheer Giannina Descalzi Tami A Martino Source Type: research

Metabolic remodeling in cancer and senescence and its therapeutic implications
Trends Endocrinol Metab. 2024 Mar 6:S1043-2760(24)00037-7. doi: 10.1016/j.tem.2024.02.008. Online ahead of print.ABSTRACTCellular metabolism is a flexible and plastic network that often dictates physiological and pathological states of the cell, including differentiation, cancer, and aging. Recent advances in cancer metabolism represent a tremendous opportunity to treat cancer by targeting its altered metabolism. Interestingly, despite their stable growth arrest, senescent cells - a critical component of the aging process - undergo metabolic changes similar to cancer metabolism. A deeper understanding of the similarities a...
Source: Trends in Endocrinology and Metabolism: TEM - March 7, 2024 Category: Endocrinology Authors: Yeonju Kim Yeji Jang Mi-Sung Kim Chanhee Kang Source Type: research

Itaconate in host inflammation and defense
Trends Endocrinol Metab. 2024 Mar 5:S1043-2760(24)00033-X. doi: 10.1016/j.tem.2024.02.004. Online ahead of print.ABSTRACTImmune cells undergo rapid and extensive metabolic changes during inflammation. In addition to contributing to energetic and biosynthetic demands, metabolites can also function as signaling molecules. Itaconate (ITA) rapidly accumulates to high levels in myeloid cells under infectious and sterile inflammatory conditions. This metabolite binds to and regulates the function of diverse proteins intracellularly to influence metabolism, oxidative response, epigenetic modification, and gene expression and to s...
Source: Trends in Endocrinology and Metabolism: TEM - March 6, 2024 Category: Endocrinology Authors: Dan Ye Pu Wang Lei-Lei Chen Kun-Liang Guan Yue Xiong Source Type: research

Endothelial lipid droplets drive atherosclerosis and arterial hypertension
Trends Endocrinol Metab. 2024 Mar 1:S1043-2760(24)00043-2. doi: 10.1016/j.tem.2024.02.014. Online ahead of print.ABSTRACTLipid droplets (LDs) are essential for cellular pathophysiology. In two recent reports, Kim et al. and Boutagy et al. show that accumulation of LDs in endothelial cells (ECs) elevates blood pressure and accelerates progression of atherosclerosis. These findings identify a novel mechanism of EC lipid metabolism which drives cardiometabolic diseases.PMID:38431437 | DOI:10.1016/j.tem.2024.02.014 (Source: Trends in Endocrinology and Metabolism: TEM)
Source: Trends in Endocrinology and Metabolism: TEM - March 2, 2024 Category: Endocrinology Authors: Suowen Xu Stefan Offermanns Source Type: research

Context matters for addressing controversies in FGF21 biology
Trends Endocrinol Metab. 2024 Mar 1:S1043-2760(24)00042-0. doi: 10.1016/j.tem.2024.02.013. Online ahead of print.ABSTRACTRecent discoveries by Solon-Biet and colleagues highlight the importance of nutritional context for addressing current controversies in Fibroblast Growth Factor 21 (FGF21) biology. Through a series of complex studies, the authors explored the physiological and pharmacological effects of FGF21 on feeding behavior and energy balance under differing nutritional and metabolic statuses.PMID:38431438 | DOI:10.1016/j.tem.2024.02.013 (Source: Trends in Endocrinology and Metabolism: TEM)
Source: Trends in Endocrinology and Metabolism: TEM - March 2, 2024 Category: Endocrinology Authors: Chih-Ting Wu Karen K Ryan Source Type: research