Endothelial lipid droplets drive atherosclerosis and arterial hypertension

Trends Endocrinol Metab. 2024 Mar 1:S1043-2760(24)00043-2. doi: 10.1016/j.tem.2024.02.014. Online ahead of print.ABSTRACTLipid droplets (LDs) are essential for cellular pathophysiology. In two recent reports, Kim et al. and Boutagy et al. show that accumulation of LDs in endothelial cells (ECs) elevates blood pressure and accelerates progression of atherosclerosis. These findings identify a novel mechanism of EC lipid metabolism which drives cardiometabolic diseases.PMID:38431437 | DOI:10.1016/j.tem.2024.02.014
Source: Trends in Endocrinology and Metabolism: TEM - Category: Endocrinology Authors: Source Type: research