Trends in Endocrinology and Metabolism: TEM This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Ironing out obesity
Trends Endocrinol Metab. 2024 Apr 9:S1043-2760(24)00084-5. doi: 10.1016/j.tem.2024.04.001. Online ahead of print.ABSTRACTObesity is associated with dysfunctions in hypothalamic neurons that regulate metabolism, including agouti-related protein (AgRP)-expressing neurons. In a recent article, Zhang et al. demonstrated that either diet- or genetically induced obesity promoted iron accumulation specifically in AgRP neurons. Preventing iron overload in AgRP neurons mitigated diet-induced obesity and related comorbidities in male mice.PMID:38599900 | DOI:10.1016/j.tem.2024.04.001 (Source: Trends in Endocrinology and Metabolism: TEM)
Source: Trends in Endocrinology and Metabolism: TEM - April 10, 2024 Category: Endocrinology Authors: Gabriel O de Souza Willian O Dos Santos Jose Donato Source Type: research

Mitochondrial morphology, distribution and activity during oocyte development
Trends Endocrinol Metab. 2024 Apr 9:S1043-2760(24)00064-X. doi: 10.1016/j.tem.2024.03.002. Online ahead of print.ABSTRACTMitochondria have a crucial role in cellular function and exhibit remarkable plasticity, adjusting both their structure and activity to meet the changing energy demands of a cell. Oocytes, female germ cells that become eggs, undergo unique transformations: the extended dormancy period, followed by substantial increase in cell size and subsequent maturation involving the segregation of genetic material for the next generation, present distinct metabolic challenges necessitating varied mitochondrial adapta...
Source: Trends in Endocrinology and Metabolism: TEM - April 10, 2024 Category: Endocrinology Authors: Devesh Bahety Elvan B öke Aida Rodr íguez-Nuevo Source Type: research

Is MASLD lost in translation in mice?
Trends Endocrinol Metab. 2024 Apr 9:S1043-2760(24)00080-8. doi: 10.1016/j.tem.2024.03.005. Online ahead of print.ABSTRACTLack of preclinical model translation is often blamed for failed drug development. Here we discuss mouse models within the context of human steatotic liver disease (SLD). Variables such as aging and non-food hepatic stressors are often ignored but could explain challenges in reproducing the human disease in a laboratory.PMID:38599902 | DOI:10.1016/j.tem.2024.03.005 (Source: Trends in Endocrinology and Metabolism: TEM)
Source: Trends in Endocrinology and Metabolism: TEM - April 10, 2024 Category: Endocrinology Authors: Aysim Gunes Jennifer L Estall Source Type: research

Selenium, diabetes, and their intricate sex-specific relationship
Trends Endocrinol Metab. 2024 Apr 10:S1043-2760(24)00066-3. doi: 10.1016/j.tem.2024.03.004. Online ahead of print.ABSTRACTSelenium (Se) is an essential trace element, which is inserted as selenocysteine (Sec) into selenoproteins during biosynthesis, orchestrating their expression and activity. Se is associated with both beneficial and detrimental health effects; deficient supply or uncontrolled supplementation raises concerns. In particular, Se was associated with an increased incidence of type 2 diabetes (T2D) in a secondary analysis of a randomized controlled trial (RCT). In this review, we discuss the intricate relation...
Source: Trends in Endocrinology and Metabolism: TEM - April 10, 2024 Category: Endocrinology Authors: Kamil Demircan Thilo Samson Chillon Jeyoung Bang Vadim N Gladyshev Lutz Schomburg Source Type: research

A double-edged sword: risks and benefits of heat for human health
Trends Endocrinol Metab. 2024 Apr;35(4):277-279. doi: 10.1016/j.tem.2024.02.015.ABSTRACTExtreme heat events will become more frequent and intense across the globe. In this science and society article we summarize how heat affects our body and discuss the associated health threats, but also the potential health benefits of heat exposure. Moreover, we provide practical suggestions for sustainable and health-oriented strategies to cope with heat.PMID:38593784 | DOI:10.1016/j.tem.2024.02.015 (Source: Trends in Endocrinology and Metabolism: TEM)
Source: Trends in Endocrinology and Metabolism: TEM - April 9, 2024 Category: Endocrinology Authors: Hannah Pallubinsky Denis P Blondin Ollie Jay Source Type: research

'NO-how' enzymatic S-nitrosylation controls insulin pathophysiology
Trends Endocrinol Metab. 2024 Feb 28:S1043-2760(24)00039-0. doi: 10.1016/j.tem.2024.02.010. Online ahead of print.ABSTRACTWhether S-nitrosylation is the result of an unselective chemical process or enzymatically driven has been debated for years. A recent study by Zhou et al. identifies and characterizes the first S-nitroso-CoA (SNO-CoA)-assisted nitrosylase (SCAN) that catalyzes protein S-nitrosylation in mammals, including insulin receptor (INSR)/insulin receptor substrate 1 (IRS1), with implications for human metabolism.PMID:38587367 | DOI:10.1016/j.tem.2024.02.010 (Source: Trends in Endocrinology and Metabolism: TEM)
Source: Trends in Endocrinology and Metabolism: TEM - April 8, 2024 Category: Endocrinology Authors: Giuseppe Filomeni Source Type: research

Common and divergent molecular mechanisms of fasting and ketogenic diets
Trends Endocrinol Metab. 2024 Feb;35(2):125-141. doi: 10.1016/j.tem.2023.10.001. Epub 2023 Oct 28.ABSTRACTIntermittent short-term fasting (ISTF) and ketogenic diets (KDs) exert overlapping but not identical effects on cell metabolism, function, and resilience. Whereas health benefits of KD are largely mediated by the ketone bodies (KBs), ISTF engages additional adaptive physiological responses. KDs act mainly through inhibition of histone deacetylases (HDACs), reduction of oxidative stress, improvement of mitochondria efficiency, and control of inflammation. Mechanisms of action of ISTF include stimulation of autophagy, in...
Source: Trends in Endocrinology and Metabolism: TEM - April 5, 2024 Category: Endocrinology Authors: Antonio Paoli Grant M Tinsley Mark P Mattson Immaculata De Vivo Ravi Dhawan Tatiana Moro Source Type: research

Emerging methods for genome-scale metabolic modeling of microbial communities
Trends Endocrinol Metab. 2024 Apr 3:S1043-2760(24)00062-6. doi: 10.1016/j.tem.2024.02.018. Online ahead of print.ABSTRACTGenome-scale metabolic models (GEMs) are consolidating as platforms for studying mixed microbial populations, by combining biological data and knowledge with mathematical rigor. However, deploying these models to answer research questions can be challenging due to the increasing number of available computational tools, the lack of universal standards, and their inherent limitations. Here, we present a comprehensive overview of foundational concepts for building and evaluating genome-scale models of micro...
Source: Trends in Endocrinology and Metabolism: TEM - April 4, 2024 Category: Endocrinology Authors: Chaimaa Tarzi Guido Zampieri Neil Sullivan Claudio Angione Source Type: research