'NO-how' enzymatic S-nitrosylation controls insulin pathophysiology

Trends Endocrinol Metab. 2024 Feb 28:S1043-2760(24)00039-0. doi: 10.1016/j.tem.2024.02.010. Online ahead of print.ABSTRACTWhether S-nitrosylation is the result of an unselective chemical process or enzymatically driven has been debated for years. A recent study by Zhou et al. identifies and characterizes the first S-nitroso-CoA (SNO-CoA)-assisted nitrosylase (SCAN) that catalyzes protein S-nitrosylation in mammals, including insulin receptor (INSR)/insulin receptor substrate 1 (IRS1), with implications for human metabolism.PMID:38587367 | DOI:10.1016/j.tem.2024.02.010
Source: Trends in Endocrinology and Metabolism: TEM - Category: Endocrinology Authors: Source Type: research