Trends in Endocrinology and Metabolism: TEM 
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Trends Endocrinol Metab. 2024 Apr 3:S1043-2760(24)00063-8. doi: 10.1016/j.tem.2024.03.001. Online ahead of print.ABSTRACTEn masse phenotyping technology, using massively mosaic donor-derived cells and organoids, can offer enriched insights for cellotype-phenotype association in a cell-type-specific regulatory context. This emerging approach will help to discover biomarkers, inform genetic-epigenetic interactions and identify personalized therapeutic targets, offering hope for precision medicine against highly heterogeneous metabolic diseases.PMID:38575442 | DOI:10.1016/j.tem.2024.03.001 (Source: Trends in Endocrinology and Metabolism: TEM)
Source: Trends in Endocrinology and Metabolism: TEM - April 4, 2024 Category: Endocrinology Authors: Masaki Kimura Takanori Takebe Source Type: research
A perspective on muscle phenotyping in musculoskeletal research
Trends Endocrinol Metab. 2024 Mar 28:S1043-2760(24)00018-3. doi: 10.1016/j.tem.2024.01.004. Online ahead of print.ABSTRACTMusculoskeletal research should synergistically investigate bone and muscle to inform approaches for maintaining mobility and to avoid bone fractures. The relationship between sarcopenia and osteoporosis, integrated in the term 'osteosarcopenia', is underscored by the close association shown between these two conditions in many studies, whereby one entity emerges as a predictor of the other. In a recent workshop of Working Group (WG) 2 of the EU Cooperation in Science and Technology (COST) Action 'Genom...
Source: Trends in Endocrinology and Metabolism: TEM - March 29, 2024 Category: Endocrinology Authors: Ines Foessl Cheryl L Ackert-Bicknell Erika Kague Faidra Laskou Franz Jakob David Karasik Barbara Obermayer-Pietsch Co-authors Source Type: research
A perspective on muscle phenotyping in musculoskeletal research
Trends Endocrinol Metab. 2024 Mar 28:S1043-2760(24)00018-3. doi: 10.1016/j.tem.2024.01.004. Online ahead of print.ABSTRACTMusculoskeletal research should synergistically investigate bone and muscle to inform approaches for maintaining mobility and to avoid bone fractures. The relationship between sarcopenia and osteoporosis, integrated in the term 'osteosarcopenia', is underscored by the close association shown between these two conditions in many studies, whereby one entity emerges as a predictor of the other. In a recent workshop of Working Group (WG) 2 of the EU Cooperation in Science and Technology (COST) Action 'Genom...
Source: Trends in Endocrinology and Metabolism: TEM - March 29, 2024 Category: Endocrinology Authors: Ines Foessl Cheryl L Ackert-Bicknell Erika Kague Faidra Laskou Franz Jakob David Karasik Barbara Obermayer-Pietsch Co-authors Source Type: research
A perspective on muscle phenotyping in musculoskeletal research
Trends Endocrinol Metab. 2024 Mar 28:S1043-2760(24)00018-3. doi: 10.1016/j.tem.2024.01.004. Online ahead of print.ABSTRACTMusculoskeletal research should synergistically investigate bone and muscle to inform approaches for maintaining mobility and to avoid bone fractures. The relationship between sarcopenia and osteoporosis, integrated in the term 'osteosarcopenia', is underscored by the close association shown between these two conditions in many studies, whereby one entity emerges as a predictor of the other. In a recent workshop of Working Group (WG) 2 of the EU Cooperation in Science and Technology (COST) Action 'Genom...
Source: Trends in Endocrinology and Metabolism: TEM - March 29, 2024 Category: Endocrinology Authors: Ines Foessl Cheryl L Ackert-Bicknell Erika Kague Faidra Laskou Franz Jakob David Karasik Barbara Obermayer-Pietsch Co-authors Source Type: research
A perspective on muscle phenotyping in musculoskeletal research
Trends Endocrinol Metab. 2024 Mar 28:S1043-2760(24)00018-3. doi: 10.1016/j.tem.2024.01.004. Online ahead of print.ABSTRACTMusculoskeletal research should synergistically investigate bone and muscle to inform approaches for maintaining mobility and to avoid bone fractures. The relationship between sarcopenia and osteoporosis, integrated in the term 'osteosarcopenia', is underscored by the close association shown between these two conditions in many studies, whereby one entity emerges as a predictor of the other. In a recent workshop of Working Group (WG) 2 of the EU Cooperation in Science and Technology (COST) Action 'Genom...
Source: Trends in Endocrinology and Metabolism: TEM - March 29, 2024 Category: Endocrinology Authors: Ines Foessl Cheryl L Ackert-Bicknell Erika Kague Faidra Laskou Franz Jakob David Karasik Barbara Obermayer-Pietsch Co-authors Source Type: research
A perspective on muscle phenotyping in musculoskeletal research
Trends Endocrinol Metab. 2024 Mar 28:S1043-2760(24)00018-3. doi: 10.1016/j.tem.2024.01.004. Online ahead of print.ABSTRACTMusculoskeletal research should synergistically investigate bone and muscle to inform approaches for maintaining mobility and to avoid bone fractures. The relationship between sarcopenia and osteoporosis, integrated in the term 'osteosarcopenia', is underscored by the close association shown between these two conditions in many studies, whereby one entity emerges as a predictor of the other. In a recent workshop of Working Group (WG) 2 of the EU Cooperation in Science and Technology (COST) Action 'Genom...
Source: Trends in Endocrinology and Metabolism: TEM - March 29, 2024 Category: Endocrinology Authors: Ines Foessl Cheryl L Ackert-Bicknell Erika Kague Faidra Laskou Franz Jakob David Karasik Barbara Obermayer-Pietsch Co-authors Source Type: research
Unveiling the cancer risk nexus of the steatotic liver
Trends Endocrinol Metab. 2024 Mar 25:S1043-2760(24)00060-2. doi: 10.1016/j.tem.2024.02.017. Online ahead of print.ABSTRACTSteatotic liver, characterized by the accumulation of fat in the liver, poses significant health risks including metabolic dysfunction-associated steatotic liver disease (MASLD) and an elevated risk of primary liver cancer. Emerging evidence indicates a robust association between steatotic liver and increased susceptibility to extrahepatic primary cancers and their metastases. The deposition of fat induces dynamic changes in hepatic microenvironments, thereby fostering inflammation and immune responses ...
Source: Trends in Endocrinology and Metabolism: TEM - March 26, 2024 Category: Endocrinology Authors: Jieun Kim Ekihiro Seki Source Type: research
Unveiling the cancer risk nexus of the steatotic liver
Trends Endocrinol Metab. 2024 Mar 25:S1043-2760(24)00060-2. doi: 10.1016/j.tem.2024.02.017. Online ahead of print.ABSTRACTSteatotic liver, characterized by the accumulation of fat in the liver, poses significant health risks including metabolic dysfunction-associated steatotic liver disease (MASLD) and an elevated risk of primary liver cancer. Emerging evidence indicates a robust association between steatotic liver and increased susceptibility to extrahepatic primary cancers and their metastases. The deposition of fat induces dynamic changes in hepatic microenvironments, thereby fostering inflammation and immune responses ...
Source: Trends in Endocrinology and Metabolism: TEM - March 26, 2024 Category: Endocrinology Authors: Jieun Kim Ekihiro Seki Source Type: research
Unveiling the cancer risk nexus of the steatotic liver
Trends Endocrinol Metab. 2024 Mar 25:S1043-2760(24)00060-2. doi: 10.1016/j.tem.2024.02.017. Online ahead of print.ABSTRACTSteatotic liver, characterized by the accumulation of fat in the liver, poses significant health risks including metabolic dysfunction-associated steatotic liver disease (MASLD) and an elevated risk of primary liver cancer. Emerging evidence indicates a robust association between steatotic liver and increased susceptibility to extrahepatic primary cancers and their metastases. The deposition of fat induces dynamic changes in hepatic microenvironments, thereby fostering inflammation and immune responses ...
Source: Trends in Endocrinology and Metabolism: TEM - March 26, 2024 Category: Endocrinology Authors: Jieun Kim Ekihiro Seki Source Type: research
A unified model for regulating lipoprotein lipase activity
Trends Endocrinol Metab. 2024 Mar 23:S1043-2760(24)00045-6. doi: 10.1016/j.tem.2024.02.016. Online ahead of print.ABSTRACTThe regulation of triglyceride (TG) tissue distribution, storage, and utilization, a fundamental process of energy homeostasis, critically depends on lipoprotein lipase (LPL). We review the intricate mechanisms by which LPL activity is regulated by angiopoietin-like proteins (ANGPTL3, 4, 8), apolipoproteins (APOA5, APOC3, APOC2), and the cAMP-responsive element-binding protein H (CREBH). ANGPTL8 functions as a molecular switch, through complex formation, activating ANGPTL3 while deactivating ANGPTL4 in ...
Source: Trends in Endocrinology and Metabolism: TEM - March 23, 2024 Category: Endocrinology Authors: Ren Zhang Kezhong Zhang Source Type: research
A unified model for regulating lipoprotein lipase activity
Trends Endocrinol Metab. 2024 Mar 23:S1043-2760(24)00045-6. doi: 10.1016/j.tem.2024.02.016. Online ahead of print.ABSTRACTThe regulation of triglyceride (TG) tissue distribution, storage, and utilization, a fundamental process of energy homeostasis, critically depends on lipoprotein lipase (LPL). We review the intricate mechanisms by which LPL activity is regulated by angiopoietin-like proteins (ANGPTL3, 4, 8), apolipoproteins (APOA5, APOC3, APOC2), and the cAMP-responsive element-binding protein H (CREBH). ANGPTL8 functions as a molecular switch, through complex formation, activating ANGPTL3 while deactivating ANGPTL4 in ...
Source: Trends in Endocrinology and Metabolism: TEM - March 23, 2024 Category: Endocrinology Authors: Ren Zhang Kezhong Zhang Source Type: research
A unified model for regulating lipoprotein lipase activity
Trends Endocrinol Metab. 2024 Mar 23:S1043-2760(24)00045-6. doi: 10.1016/j.tem.2024.02.016. Online ahead of print.ABSTRACTThe regulation of triglyceride (TG) tissue distribution, storage, and utilization, a fundamental process of energy homeostasis, critically depends on lipoprotein lipase (LPL). We review the intricate mechanisms by which LPL activity is regulated by angiopoietin-like proteins (ANGPTL3, 4, 8), apolipoproteins (APOA5, APOC3, APOC2), and the cAMP-responsive element-binding protein H (CREBH). ANGPTL8 functions as a molecular switch, through complex formation, activating ANGPTL3 while deactivating ANGPTL4 in ...
Source: Trends in Endocrinology and Metabolism: TEM - March 23, 2024 Category: Endocrinology Authors: Ren Zhang Kezhong Zhang Source Type: research
Pioneering new frontiers in circadian medicine chronotherapies for cardiovascular health
Trends Endocrinol Metab. 2024 Mar 7:S1043-2760(24)00040-7. doi: 10.1016/j.tem.2024.02.011. Online ahead of print.ABSTRACTCardiovascular disease (CVD) is a global health concern. Circadian medicine improves cardiovascular care by aligning treatments with our body's daily rhythms and their underlying cellular circadian mechanisms. Time-based therapies, or chronotherapies, show special promise in clinical cardiology. They optimize treatment schedules for better outcomes with fewer side effects by recognizing the profound influence of rhythmic body cycles. In this review, we focus on three chronotherapy areas (medication, ligh...
Source: Trends in Endocrinology and Metabolism: TEM - March 8, 2024 Category: Endocrinology Authors: Ifene David Festus Jeri Spilberg Martin E Young Sean Cain Sepideh Khoshnevis Michael H Smolensky Fariya Zaheer Giannina Descalzi Tami A Martino Source Type: research
Pioneering new frontiers in circadian medicine chronotherapies for cardiovascular health
Trends Endocrinol Metab. 2024 Mar 7:S1043-2760(24)00040-7. doi: 10.1016/j.tem.2024.02.011. Online ahead of print.ABSTRACTCardiovascular disease (CVD) is a global health concern. Circadian medicine improves cardiovascular care by aligning treatments with our body's daily rhythms and their underlying cellular circadian mechanisms. Time-based therapies, or chronotherapies, show special promise in clinical cardiology. They optimize treatment schedules for better outcomes with fewer side effects by recognizing the profound influence of rhythmic body cycles. In this review, we focus on three chronotherapy areas (medication, ligh...
Source: Trends in Endocrinology and Metabolism: TEM - March 8, 2024 Category: Endocrinology Authors: Ifene David Festus Jeri Spilberg Martin E Young Sean Cain Sepideh Khoshnevis Michael H Smolensky Fariya Zaheer Giannina Descalzi Tami A Martino Source Type: research
Pioneering new frontiers in circadian medicine chronotherapies for cardiovascular health
Trends Endocrinol Metab. 2024 Mar 7:S1043-2760(24)00040-7. doi: 10.1016/j.tem.2024.02.011. Online ahead of print.ABSTRACTCardiovascular disease (CVD) is a global health concern. Circadian medicine improves cardiovascular care by aligning treatments with our body's daily rhythms and their underlying cellular circadian mechanisms. Time-based therapies, or chronotherapies, show special promise in clinical cardiology. They optimize treatment schedules for better outcomes with fewer side effects by recognizing the profound influence of rhythmic body cycles. In this review, we focus on three chronotherapy areas (medication, ligh...
Source: Trends in Endocrinology and Metabolism: TEM - March 8, 2024 Category: Endocrinology Authors: Ifene David Festus Jeri Spilberg Martin E Young Sean Cain Sepideh Khoshnevis Michael H Smolensky Fariya Zaheer Giannina Descalzi Tami A Martino Source Type: research
