Trends in Endocrinology and Metabolism: TEM This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

The ups and downs of bone-marrow adipose tissue in space
Trends Endocrinol Metab. 2023 Nov 30:S1043-2760(23)00242-4. doi: 10.1016/j.tem.2023.11.003. Online ahead of print.ABSTRACTKnowledge is rapidly accumulating on basic roles and modulation of bone-marrow adipose tissue (BMAT). Among key modulators are physical forces on bones as exerted by gravity and exercise. Studying humans returning from space has revealed that, in addition to physical forces, local energetics within the bone marrow can play modulatory roles.PMID:38040579 | DOI:10.1016/j.tem.2023.11.003 (Source: Trends in Endocrinology and Metabolism: TEM)
Source: Trends in Endocrinology and Metabolism: TEM - December 1, 2023 Category: Endocrinology Authors: Guy Trudel Gerd Melkus Tammy Liu Source Type: research

The evolutionary tug-of-war of macrophage metabolism during bacterial infection
Trends Endocrinol Metab. 2023 Nov 30:S1043-2760(23)00241-2. doi: 10.1016/j.tem.2023.11.002. Online ahead of print.ABSTRACTThe function and phenotype of macrophages are intimately linked with pathogen detection. On sensing pathogen-derived signals and molecules, macrophages undergo a carefully orchestrated process of polarization to acquire pathogen-clearing properties. This phenotypic change must be adequately supported by metabolic reprogramming that is now known to support the acquisition of effector function, but also generates secondary metabolites with direct microbicidal activity. At the same time, bacteria themselve...
Source: Trends in Endocrinology and Metabolism: TEM - December 1, 2023 Category: Endocrinology Authors: Lu ís Almeida Ayesha Dhillon-LaBrooy Tim Sparwasser Source Type: research

Methylmalonic acid in aging and disease
Trends Endocrinol Metab. 2023 Nov 28:S1043-2760(23)00240-0. doi: 10.1016/j.tem.2023.11.001. Online ahead of print.ABSTRACTMetabolic byproducts have conventionally been disregarded as waste products without functions. In this opinion article, we bring to light the multifaceted role of methylmalonic acid (MMA), a byproduct of the propionate metabolism pathway mostly commonly known as a clinical biomarker of vitamin B12 deficiency. MMA is normally present at low levels in the body, but increased levels can come from different sources, such as vitamin B12 deficiency, genetic mutations in enzymes related to the propionate pathw...
Source: Trends in Endocrinology and Metabolism: TEM - November 29, 2023 Category: Endocrinology Authors: Joanne Tejero Felicia Lazure Ana P Gomes Source Type: research

Cardiac macrophage metabolism in health and disease
Trends Endocrinol Metab. 2023 Nov 21:S1043-2760(23)00237-0. doi: 10.1016/j.tem.2023.10.011. Online ahead of print.ABSTRACTCardiac macrophages are essential mediators of cardiac development, tissue homeostasis, and response to injury. Cell-intrinsic shifts in metabolism and availability of metabolites regulate macrophage function. The human and mouse heart contain a heterogeneous compilation of cardiac macrophages that are derived from at least two distinct lineages. In this review, we detail the unique functional roles and metabolic profiles of tissue-resident and monocyte-derived cardiac macrophages during embryonic devel...
Source: Trends in Endocrinology and Metabolism: TEM - November 22, 2023 Category: Endocrinology Authors: Benjamin J Kopecky Kory J Lavine Source Type: research

Regulated cell death in myocardial ischemia-reperfusion injury
Trends Endocrinol Metab. 2023 Nov 17:S1043-2760(23)00223-0. doi: 10.1016/j.tem.2023.10.010. Online ahead of print.ABSTRACTMyocardial ischemia-reperfusion (I/R) injury most commonly occurs in coronary artery disease when prompt reperfusion is used to salvage the ischemic myocardium. Cardiomyocyte death is a significant component of myocardial I/R injury and its mechanism was previously thought to be limited to apoptosis and necrosis. With the discovery of novel types of cell death, ferroptosis, necroptosis, and pyroptosis have been shown to be involved in myocardial I/R. These new forms of regulated cell death cause cardiom...
Source: Trends in Endocrinology and Metabolism: TEM - November 19, 2023 Category: Endocrinology Authors: Qi Xiang Xin Yi Xue-Hai Zhu Xiang Wei Ding-Sheng Jiang Source Type: research