Trends in Endocrinology and Metabolism: TEM 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.The dangerous trend of levothyroxine medicalization
Trends Endocrinol Metab. 2023 Sep 13:S1043-2760(23)00184-4. doi: 10.1016/j.tem.2023.08.017. Online ahead of print.ABSTRACTThyroid hormone replacement is paramount in overt hypothyroidism; recently, however, thyroid hormone substitution is increasingly prescribed to patients with normal thyroid hormone levels. This forum article discusses the complex causes and the possible negative effects of overusing thyroid hormone replacement drugs.PMID:37714811 | DOI:10.1016/j.tem.2023.08.017 (Source: Trends in Endocrinology and Metabolism: TEM)
Source: Trends in Endocrinology and Metabolism: TEM - September 15, 2023 Category: Endocrinology Authors: Jan Calissendorff Source Type: research
Mechanisms and pathophysiology of SARS-CoV-2 infection of the adipose tissue
Trends Endocrinol Metab. 2023 Sep 4:S1043-2760(23)00163-7. doi: 10.1016/j.tem.2023.08.010. Online ahead of print.ABSTRACTObesity is an independent risk factor for severe COVID-19, yet there remains a lack of consensus on the mechanisms underlying this relationship. A hypothesis that has garnered considerable attention suggests that SARS-CoV-2 disrupts adipose tissue function, either through direct infection or by indirect mechanisms. Indeed, recent reports have begun to shed some light on the important role that the adipose tissue plays during the acute phase of infection, as well as mediating long-term sequelae. In this r...
Source: Trends in Endocrinology and Metabolism: TEM - September 6, 2023 Category: Endocrinology Authors: Jill Moser Marloes Emous Peter Heeringa Izabela A Rodenhuis-Zybert Source Type: research
Sensing mitochondrial DNA stress in cardiotoxicity
Trends Endocrinol Metab. 2023 Sep 4:S1043-2760(23)00165-0. doi: 10.1016/j.tem.2023.08.012. Online ahead of print.ABSTRACTCytoplasmic mitochondrial DNA (mtDNA) can trigger the interferon response to promote disease progression, but mtDNA sensing mechanisms remain elusive. Lei et al. have shown that Z-DNA binding protein1 (ZBP1) cooperates with cyclic GMP-AMP synthase (cGAS) to sense Z-form mtDNA and transmit mtDNA stress signals to promote diseases such as cardiotoxicity, providing an important piece of the mtDNA stress landscape.PMID:37673764 | DOI:10.1016/j.tem.2023.08.012 (Source: Trends in Endocrinology and Metabolism: TEM)
Source: Trends in Endocrinology and Metabolism: TEM - September 6, 2023 Category: Endocrinology Authors: Yang-Nan Ding Xiaoqiang Tang Source Type: research
Metabolic control by AMPK in white adipose tissue
Trends Endocrinol Metab. 2023 Sep 4:S1043-2760(23)00164-9. doi: 10.1016/j.tem.2023.08.011. Online ahead of print.ABSTRACTWhite adipose tissue (WAT) plays an important role in the integration of whole-body metabolism by storing fat and mobilizing triacylglycerol when needed. The released free fatty acids can then be oxidized by other tissues to provide ATP. AMP-activated protein kinase (AMPK) is a key regulator of metabolic pathways, and can be targeted by a new generation of direct, small-molecule activators. AMPK activation in WAT inhibits insulin-stimulated lipogenesis and in some situations also inhibits insulin-stimula...
Source: Trends in Endocrinology and Metabolism: TEM - September 6, 2023 Category: Endocrinology Authors: Olga G öransson Franziska Kopietz Mark H Rider Source Type: research
Pre-RNA splicing in metabolic homeostasis and liver disease
Trends Endocrinol Metab. 2023 Sep 4:S1043-2760(23)00160-1. doi: 10.1016/j.tem.2023.08.007. Online ahead of print.ABSTRACTThe liver plays a key role in sensing nutritional and hormonal inputs to maintain metabolic homeostasis. Recent studies into pre-mRNA splicing and alternative splicing (AS) and their effects on gene expression have revealed considerable transcriptional complexity in the liver, both in health and disease. While the contribution of these mechanisms to cell and tissue identity is widely accepted, their role in physiological and pathological contexts within tissues is just beginning to be appreciated. In thi...
Source: Trends in Endocrinology and Metabolism: TEM - September 6, 2023 Category: Endocrinology Authors: Andrew M Jobbins Sijia Yu Helen A B Paterson Hannah Maude Antonia Kefala-Stavridi Christian Speck In ês Cebola Santiago Vernia Source Type: research
Mechanisms and pathophysiology of SARS-CoV-2 infection of the adipose tissue
Trends Endocrinol Metab. 2023 Sep 4:S1043-2760(23)00163-7. doi: 10.1016/j.tem.2023.08.010. Online ahead of print.ABSTRACTObesity is an independent risk factor for severe COVID-19, yet there remains a lack of consensus on the mechanisms underlying this relationship. A hypothesis that has garnered considerable attention suggests that SARS-CoV-2 disrupts adipose tissue function, either through direct infection or by indirect mechanisms. Indeed, recent reports have begun to shed some light on the important role that the adipose tissue plays during the acute phase of infection, as well as mediating long-term sequelae. In this r...
Source: Trends in Endocrinology and Metabolism: TEM - September 6, 2023 Category: Endocrinology Authors: Jill Moser Marloes Emous Peter Heeringa Izabela A Rodenhuis-Zybert Source Type: research
Sensing mitochondrial DNA stress in cardiotoxicity
Trends Endocrinol Metab. 2023 Sep 4:S1043-2760(23)00165-0. doi: 10.1016/j.tem.2023.08.012. Online ahead of print.ABSTRACTCytoplasmic mitochondrial DNA (mtDNA) can trigger the interferon response to promote disease progression, but mtDNA sensing mechanisms remain elusive. Lei et al. have shown that Z-DNA binding protein1 (ZBP1) cooperates with cyclic GMP-AMP synthase (cGAS) to sense Z-form mtDNA and transmit mtDNA stress signals to promote diseases such as cardiotoxicity, providing an important piece of the mtDNA stress landscape.PMID:37673764 | DOI:10.1016/j.tem.2023.08.012 (Source: Trends in Endocrinology and Metabolism: TEM)
Source: Trends in Endocrinology and Metabolism: TEM - September 6, 2023 Category: Endocrinology Authors: Yang-Nan Ding Xiaoqiang Tang Source Type: research
Metabolic control by AMPK in white adipose tissue
Trends Endocrinol Metab. 2023 Sep 4:S1043-2760(23)00164-9. doi: 10.1016/j.tem.2023.08.011. Online ahead of print.ABSTRACTWhite adipose tissue (WAT) plays an important role in the integration of whole-body metabolism by storing fat and mobilizing triacylglycerol when needed. The released free fatty acids can then be oxidized by other tissues to provide ATP. AMP-activated protein kinase (AMPK) is a key regulator of metabolic pathways, and can be targeted by a new generation of direct, small-molecule activators. AMPK activation in WAT inhibits insulin-stimulated lipogenesis and in some situations also inhibits insulin-stimula...
Source: Trends in Endocrinology and Metabolism: TEM - September 6, 2023 Category: Endocrinology Authors: Olga G öransson Franziska Kopietz Mark H Rider Source Type: research
Pre-RNA splicing in metabolic homeostasis and liver disease
Trends Endocrinol Metab. 2023 Sep 4:S1043-2760(23)00160-1. doi: 10.1016/j.tem.2023.08.007. Online ahead of print.ABSTRACTThe liver plays a key role in sensing nutritional and hormonal inputs to maintain metabolic homeostasis. Recent studies into pre-mRNA splicing and alternative splicing (AS) and their effects on gene expression have revealed considerable transcriptional complexity in the liver, both in health and disease. While the contribution of these mechanisms to cell and tissue identity is widely accepted, their role in physiological and pathological contexts within tissues is just beginning to be appreciated. In thi...
Source: Trends in Endocrinology and Metabolism: TEM - September 6, 2023 Category: Endocrinology Authors: Andrew M Jobbins Sijia Yu Helen A B Paterson Hannah Maude Antonia Kefala-Stavridi Christian Speck In ês Cebola Santiago Vernia Source Type: research
Mechanisms and pathophysiology of SARS-CoV-2 infection of the adipose tissue
Trends Endocrinol Metab. 2023 Sep 4:S1043-2760(23)00163-7. doi: 10.1016/j.tem.2023.08.010. Online ahead of print.ABSTRACTObesity is an independent risk factor for severe COVID-19, yet there remains a lack of consensus on the mechanisms underlying this relationship. A hypothesis that has garnered considerable attention suggests that SARS-CoV-2 disrupts adipose tissue function, either through direct infection or by indirect mechanisms. Indeed, recent reports have begun to shed some light on the important role that the adipose tissue plays during the acute phase of infection, as well as mediating long-term sequelae. In this r...
Source: Trends in Endocrinology and Metabolism: TEM - September 6, 2023 Category: Endocrinology Authors: Jill Moser Marloes Emous Peter Heeringa Izabela A Rodenhuis-Zybert Source Type: research
Sensing mitochondrial DNA stress in cardiotoxicity
Trends Endocrinol Metab. 2023 Sep 4:S1043-2760(23)00165-0. doi: 10.1016/j.tem.2023.08.012. Online ahead of print.ABSTRACTCytoplasmic mitochondrial DNA (mtDNA) can trigger the interferon response to promote disease progression, but mtDNA sensing mechanisms remain elusive. Lei et al. have shown that Z-DNA binding protein1 (ZBP1) cooperates with cyclic GMP-AMP synthase (cGAS) to sense Z-form mtDNA and transmit mtDNA stress signals to promote diseases such as cardiotoxicity, providing an important piece of the mtDNA stress landscape.PMID:37673764 | DOI:10.1016/j.tem.2023.08.012 (Source: Trends in Endocrinology and Metabolism: TEM)
Source: Trends in Endocrinology and Metabolism: TEM - September 6, 2023 Category: Endocrinology Authors: Yang-Nan Ding Xiaoqiang Tang Source Type: research
Metabolic control by AMPK in white adipose tissue
Trends Endocrinol Metab. 2023 Sep 4:S1043-2760(23)00164-9. doi: 10.1016/j.tem.2023.08.011. Online ahead of print.ABSTRACTWhite adipose tissue (WAT) plays an important role in the integration of whole-body metabolism by storing fat and mobilizing triacylglycerol when needed. The released free fatty acids can then be oxidized by other tissues to provide ATP. AMP-activated protein kinase (AMPK) is a key regulator of metabolic pathways, and can be targeted by a new generation of direct, small-molecule activators. AMPK activation in WAT inhibits insulin-stimulated lipogenesis and in some situations also inhibits insulin-stimula...
Source: Trends in Endocrinology and Metabolism: TEM - September 6, 2023 Category: Endocrinology Authors: Olga G öransson Franziska Kopietz Mark H Rider Source Type: research
Pre-RNA splicing in metabolic homeostasis and liver disease
Trends Endocrinol Metab. 2023 Sep 4:S1043-2760(23)00160-1. doi: 10.1016/j.tem.2023.08.007. Online ahead of print.ABSTRACTThe liver plays a key role in sensing nutritional and hormonal inputs to maintain metabolic homeostasis. Recent studies into pre-mRNA splicing and alternative splicing (AS) and their effects on gene expression have revealed considerable transcriptional complexity in the liver, both in health and disease. While the contribution of these mechanisms to cell and tissue identity is widely accepted, their role in physiological and pathological contexts within tissues is just beginning to be appreciated. In thi...
Source: Trends in Endocrinology and Metabolism: TEM - September 6, 2023 Category: Endocrinology Authors: Andrew M Jobbins Sijia Yu Helen A B Paterson Hannah Maude Antonia Kefala-Stavridi Christian Speck In ês Cebola Santiago Vernia Source Type: research
Mechanisms and pathophysiology of SARS-CoV-2 infection of the adipose tissue
Trends Endocrinol Metab. 2023 Sep 4:S1043-2760(23)00163-7. doi: 10.1016/j.tem.2023.08.010. Online ahead of print.ABSTRACTObesity is an independent risk factor for severe COVID-19, yet there remains a lack of consensus on the mechanisms underlying this relationship. A hypothesis that has garnered considerable attention suggests that SARS-CoV-2 disrupts adipose tissue function, either through direct infection or by indirect mechanisms. Indeed, recent reports have begun to shed some light on the important role that the adipose tissue plays during the acute phase of infection, as well as mediating long-term sequelae. In this r...
Source: Trends in Endocrinology and Metabolism: TEM - September 6, 2023 Category: Endocrinology Authors: Jill Moser Marloes Emous Peter Heeringa Izabela A Rodenhuis-Zybert Source Type: research
Sensing mitochondrial DNA stress in cardiotoxicity
Trends Endocrinol Metab. 2023 Sep 4:S1043-2760(23)00165-0. doi: 10.1016/j.tem.2023.08.012. Online ahead of print.ABSTRACTCytoplasmic mitochondrial DNA (mtDNA) can trigger the interferon response to promote disease progression, but mtDNA sensing mechanisms remain elusive. Lei et al. have shown that Z-DNA binding protein1 (ZBP1) cooperates with cyclic GMP-AMP synthase (cGAS) to sense Z-form mtDNA and transmit mtDNA stress signals to promote diseases such as cardiotoxicity, providing an important piece of the mtDNA stress landscape.PMID:37673764 | DOI:10.1016/j.tem.2023.08.012 (Source: Trends in Endocrinology and Metabolism: TEM)
Source: Trends in Endocrinology and Metabolism: TEM - September 6, 2023 Category: Endocrinology Authors: Yang-Nan Ding Xiaoqiang Tang Source Type: research
